-- dump date 20140618_212517 -- class Genbank::misc_feature -- table misc_feature_note -- id note 720555000001 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 720555000002 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 720555000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 720555000004 Replication initiation factor; Region: Rep_trans; pfam02486 720555000005 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 720555000006 TcpE family; Region: TcpE; pfam12648 720555000007 AAA-like domain; Region: AAA_10; pfam12846 720555000008 Domain of unknown function (DUF1874); Region: DUF1874; cl07531 720555000009 exonuclease SbcC; Region: sbcc; TIGR00618 720555000010 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 720555000011 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 720555000012 N-acetyl-D-glucosamine binding site [chemical binding]; other site 720555000013 catalytic residue [active] 720555000014 NlpC/P60 family; Region: NLPC_P60; pfam00877 720555000015 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 720555000016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555000017 binding surface 720555000018 TPR motif; other site 720555000019 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555000020 YcfA-like protein; Region: YcfA; pfam07927 720555000021 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 720555000022 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 720555000023 putative di-iron ligands [ion binding]; other site 720555000024 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 720555000025 DNA-binding site [nucleotide binding]; DNA binding site 720555000026 RNA-binding motif; other site 720555000027 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 720555000028 Transcriptional regulators [Transcription]; Region: GntR; COG1802 720555000029 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555000030 DNA-binding site [nucleotide binding]; DNA binding site 720555000031 FCD domain; Region: FCD; pfam07729 720555000032 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 720555000033 LXG domain of WXG superfamily; Region: LXG; pfam04740 720555000034 Predicted membrane protein [Function unknown]; Region: COG2364 720555000035 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 720555000036 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555000037 MarR family; Region: MarR; pfam01047 720555000038 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 720555000039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555000040 Coenzyme A binding pocket [chemical binding]; other site 720555000041 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 720555000042 EamA-like transporter family; Region: EamA; cl17759 720555000043 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 720555000044 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555000045 DNA-binding site [nucleotide binding]; DNA binding site 720555000046 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555000047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555000048 homodimer interface [polypeptide binding]; other site 720555000049 catalytic residue [active] 720555000050 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 720555000051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000052 putative substrate translocation pore; other site 720555000053 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555000054 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 720555000055 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 720555000056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555000057 DNA-binding site [nucleotide binding]; DNA binding site 720555000058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555000059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555000060 homodimer interface [polypeptide binding]; other site 720555000061 catalytic residue [active] 720555000062 Uncharacterized conserved protein [Function unknown]; Region: COG1284 720555000063 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 720555000064 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 720555000065 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 720555000066 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555000067 dimerization interface [polypeptide binding]; other site 720555000068 putative DNA binding site [nucleotide binding]; other site 720555000069 putative Zn2+ binding site [ion binding]; other site 720555000070 arsenical pump membrane protein; Provisional; Region: PRK15445 720555000071 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 720555000072 transmembrane helices; other site 720555000073 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 720555000074 Low molecular weight phosphatase family; Region: LMWPc; cd00115 720555000075 active site 720555000076 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 720555000077 Na binding site [ion binding]; other site 720555000078 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 720555000079 MarR family; Region: MarR_2; pfam12802 720555000080 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 720555000081 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 720555000082 HTH domain; Region: HTH_11; pfam08279 720555000083 Mga helix-turn-helix domain; Region: Mga; pfam05043 720555000084 PRD domain; Region: PRD; pfam00874 720555000085 PRD domain; Region: PRD; pfam00874 720555000086 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 720555000087 active site 720555000088 P-loop; other site 720555000089 phosphorylation site [posttranslational modification] 720555000090 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 720555000091 active site 720555000092 phosphorylation site [posttranslational modification] 720555000093 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 720555000094 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 720555000095 active site 720555000096 P-loop; other site 720555000097 phosphorylation site [posttranslational modification] 720555000098 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 720555000099 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 720555000100 active site 720555000101 phosphorylation site [posttranslational modification] 720555000102 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 720555000103 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 720555000104 EamA-like transporter family; Region: EamA; pfam00892 720555000105 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 720555000106 EamA-like transporter family; Region: EamA; pfam00892 720555000107 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 720555000108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555000109 DNA-binding site [nucleotide binding]; DNA binding site 720555000110 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555000111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555000112 homodimer interface [polypeptide binding]; other site 720555000113 catalytic residue [active] 720555000114 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 720555000115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 720555000116 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 720555000117 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 720555000118 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 720555000119 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 720555000120 putative DNA binding site [nucleotide binding]; other site 720555000121 putative Zn2+ binding site [ion binding]; other site 720555000122 AsnC family; Region: AsnC_trans_reg; pfam01037 720555000123 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 720555000124 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 720555000125 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555000126 ABC transporter; Region: ABC_tran_2; pfam12848 720555000127 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555000128 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 720555000129 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 720555000130 DinB family; Region: DinB; cl17821 720555000131 DinB superfamily; Region: DinB_2; pfam12867 720555000132 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 720555000133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000134 putative substrate translocation pore; other site 720555000135 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 720555000136 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 720555000137 dimer interface [polypeptide binding]; other site 720555000138 active site 720555000139 metal binding site [ion binding]; metal-binding site 720555000140 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 720555000141 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555000142 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555000143 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 720555000144 active site 720555000145 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 720555000146 glycosyltransferase, MGT family; Region: MGT; TIGR01426 720555000147 active site 720555000148 TDP-binding site; other site 720555000149 acceptor substrate-binding pocket; other site 720555000150 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 720555000151 Alkaline phosphatase homologues; Region: alkPPc; smart00098 720555000152 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 720555000153 active site 720555000154 dimer interface [polypeptide binding]; other site 720555000155 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 720555000156 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 720555000157 Beta-lactamase; Region: Beta-lactamase; pfam00144 720555000158 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 720555000159 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 720555000160 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 720555000161 Walker A/P-loop; other site 720555000162 ATP binding site [chemical binding]; other site 720555000163 Q-loop/lid; other site 720555000164 ABC transporter signature motif; other site 720555000165 Walker B; other site 720555000166 D-loop; other site 720555000167 H-loop/switch region; other site 720555000168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555000169 dimer interface [polypeptide binding]; other site 720555000170 conserved gate region; other site 720555000171 ABC-ATPase subunit interface; other site 720555000172 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 720555000173 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 720555000174 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 720555000175 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 720555000176 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 720555000177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 720555000178 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555000179 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555000180 dimerization interface [polypeptide binding]; other site 720555000181 putative DNA binding site [nucleotide binding]; other site 720555000182 putative Zn2+ binding site [ion binding]; other site 720555000183 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 720555000184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000185 putative substrate translocation pore; other site 720555000186 Transcriptional regulators [Transcription]; Region: FadR; COG2186 720555000187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555000188 DNA-binding site [nucleotide binding]; DNA binding site 720555000189 FCD domain; Region: FCD; pfam07729 720555000190 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 720555000191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000192 putative substrate translocation pore; other site 720555000193 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 720555000194 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 720555000195 Predicted transcriptional regulators [Transcription]; Region: COG1378 720555000196 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 720555000197 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 720555000198 C-terminal domain interface [polypeptide binding]; other site 720555000199 sugar binding site [chemical binding]; other site 720555000200 thiamine monophosphate kinase; Provisional; Region: PRK05731 720555000201 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 720555000202 ATP binding site [chemical binding]; other site 720555000203 dimerization interface [polypeptide binding]; other site 720555000204 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 720555000205 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 720555000206 Glycoprotease family; Region: Peptidase_M22; pfam00814 720555000207 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 720555000208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555000209 Coenzyme A binding pocket [chemical binding]; other site 720555000210 UGMP family protein; Validated; Region: PRK09604 720555000211 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 720555000212 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 720555000213 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 720555000214 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555000215 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555000216 ABC transporter; Region: ABC_tran_2; pfam12848 720555000217 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555000218 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 720555000219 trimer interface [polypeptide binding]; other site 720555000220 dimer interface [polypeptide binding]; other site 720555000221 putative active site [active] 720555000222 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 720555000223 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 720555000224 CoA binding domain; Region: CoA_binding; pfam02629 720555000225 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 720555000226 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 720555000227 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 720555000228 CAAX protease self-immunity; Region: Abi; pfam02517 720555000229 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 720555000230 oligomerisation interface [polypeptide binding]; other site 720555000231 mobile loop; other site 720555000232 roof hairpin; other site 720555000233 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 720555000234 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 720555000235 ring oligomerisation interface [polypeptide binding]; other site 720555000236 ATP/Mg binding site [chemical binding]; other site 720555000237 stacking interactions; other site 720555000238 hinge regions; other site 720555000239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 720555000240 Histidine kinase; Region: HisKA_3; pfam07730 720555000241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555000242 ATP binding site [chemical binding]; other site 720555000243 Mg2+ binding site [ion binding]; other site 720555000244 G-X-G motif; other site 720555000245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 720555000246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555000247 active site 720555000248 phosphorylation site [posttranslational modification] 720555000249 intermolecular recognition site; other site 720555000250 dimerization interface [polypeptide binding]; other site 720555000251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 720555000252 DNA binding residues [nucleotide binding] 720555000253 dimerization interface [polypeptide binding]; other site 720555000254 Putative sensor; Region: Sensor; pfam13796 720555000255 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 720555000256 Beta-lactamase; Region: Beta-lactamase; pfam00144 720555000257 S-layer homology domain; Region: SLH; pfam00395 720555000258 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 720555000259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555000260 intermolecular recognition site; other site 720555000261 active site 720555000262 dimerization interface [polypeptide binding]; other site 720555000263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 720555000264 DNA binding residues [nucleotide binding] 720555000265 dimerization interface [polypeptide binding]; other site 720555000266 AAA ATPase domain; Region: AAA_16; pfam13191 720555000267 AAA domain; Region: AAA_22; pfam13401 720555000268 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555000269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555000270 TPR motif; other site 720555000271 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555000272 binding surface 720555000273 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 720555000274 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 720555000275 inhibitor binding site; inhibition site 720555000276 catalytic Zn binding site [ion binding]; other site 720555000277 structural Zn binding site [ion binding]; other site 720555000278 NADP binding site [chemical binding]; other site 720555000279 tetramer interface [polypeptide binding]; other site 720555000280 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 720555000281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000282 putative substrate translocation pore; other site 720555000283 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 720555000284 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 720555000285 putative substrate binding site [chemical binding]; other site 720555000286 putative ATP binding site [chemical binding]; other site 720555000287 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 720555000288 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 720555000289 DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981 720555000290 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 720555000291 Repair protein; Region: Repair_PSII; pfam04536 720555000292 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 720555000293 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 720555000294 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 720555000295 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 720555000296 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 720555000297 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 720555000298 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555000299 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555000300 DNA binding residues [nucleotide binding] 720555000301 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 720555000302 dimer interface [polypeptide binding]; other site 720555000303 FMN binding site [chemical binding]; other site 720555000304 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555000305 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555000306 putative DNA binding site [nucleotide binding]; other site 720555000307 putative Zn2+ binding site [ion binding]; other site 720555000308 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 720555000309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000310 putative substrate translocation pore; other site 720555000311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000312 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 720555000313 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 720555000314 putative NAD(P) binding site [chemical binding]; other site 720555000315 catalytic Zn binding site [ion binding]; other site 720555000316 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 720555000317 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 720555000318 Cold-inducible protein YdjO; Region: YdjO; pfam14169 720555000319 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 720555000320 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 720555000321 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 720555000322 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 720555000323 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 720555000324 Multicopper oxidase; Region: Cu-oxidase; pfam00394 720555000325 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 720555000326 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 720555000327 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 720555000328 Acyltransferase family; Region: Acyl_transf_3; pfam01757 720555000329 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 720555000330 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 720555000331 MoxR-like ATPases [General function prediction only]; Region: COG0714 720555000332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555000333 Walker A motif; other site 720555000334 ATP binding site [chemical binding]; other site 720555000335 Walker B motif; other site 720555000336 arginine finger; other site 720555000337 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 720555000338 Protein of unknown function DUF58; Region: DUF58; pfam01882 720555000339 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 720555000340 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 720555000341 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 720555000342 GMP synthase; Reviewed; Region: guaA; PRK00074 720555000343 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 720555000344 AMP/PPi binding site [chemical binding]; other site 720555000345 candidate oxyanion hole; other site 720555000346 catalytic triad [active] 720555000347 potential glutamine specificity residues [chemical binding]; other site 720555000348 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 720555000349 ATP Binding subdomain [chemical binding]; other site 720555000350 Ligand Binding sites [chemical binding]; other site 720555000351 Dimerization subdomain; other site 720555000352 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 720555000353 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555000354 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555000355 DNA binding residues [nucleotide binding] 720555000356 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 720555000357 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 720555000358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 720555000359 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 720555000360 NETI protein; Region: NETI; pfam14044 720555000361 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 720555000362 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 720555000363 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 720555000364 ATP-grasp domain; Region: ATP-grasp; pfam02222 720555000365 adenylosuccinate lyase; Provisional; Region: PRK07492 720555000366 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 720555000367 tetramer interface [polypeptide binding]; other site 720555000368 active site 720555000369 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 720555000370 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 720555000371 ATP binding site [chemical binding]; other site 720555000372 active site 720555000373 substrate binding site [chemical binding]; other site 720555000374 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 720555000375 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 720555000376 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 720555000377 putative active site [active] 720555000378 catalytic triad [active] 720555000379 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 720555000380 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 720555000381 dimerization interface [polypeptide binding]; other site 720555000382 ATP binding site [chemical binding]; other site 720555000383 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 720555000384 dimerization interface [polypeptide binding]; other site 720555000385 ATP binding site [chemical binding]; other site 720555000386 amidophosphoribosyltransferase; Provisional; Region: PRK07631 720555000387 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 720555000388 active site 720555000389 tetramer interface [polypeptide binding]; other site 720555000390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 720555000391 active site 720555000392 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 720555000393 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 720555000394 dimerization interface [polypeptide binding]; other site 720555000395 putative ATP binding site [chemical binding]; other site 720555000396 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 720555000397 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 720555000398 active site 720555000399 substrate binding site [chemical binding]; other site 720555000400 cosubstrate binding site; other site 720555000401 catalytic site [active] 720555000402 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 720555000403 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 720555000404 purine monophosphate binding site [chemical binding]; other site 720555000405 dimer interface [polypeptide binding]; other site 720555000406 putative catalytic residues [active] 720555000407 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 720555000408 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 720555000409 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 720555000410 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 720555000411 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 720555000412 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 720555000413 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 720555000414 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555000415 putative DNA binding site [nucleotide binding]; other site 720555000416 putative Zn2+ binding site [ion binding]; other site 720555000417 AsnC family; Region: AsnC_trans_reg; pfam01037 720555000418 putative transporter; Provisional; Region: PRK11021 720555000419 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 720555000420 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 720555000421 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 720555000422 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 720555000423 active site 720555000424 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 720555000425 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 720555000426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 720555000427 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 720555000428 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 720555000429 active site 720555000430 FMN binding site [chemical binding]; other site 720555000431 substrate binding site [chemical binding]; other site 720555000432 3Fe-4S cluster binding site [ion binding]; other site 720555000433 PcrB family; Region: PcrB; pfam01884 720555000434 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 720555000435 substrate binding site [chemical binding]; other site 720555000436 putative active site [active] 720555000437 dimer interface [polypeptide binding]; other site 720555000438 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 720555000439 Part of AAA domain; Region: AAA_19; pfam13245 720555000440 Family description; Region: UvrD_C_2; pfam13538 720555000441 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 720555000442 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 720555000443 nucleotide binding pocket [chemical binding]; other site 720555000444 K-X-D-G motif; other site 720555000445 catalytic site [active] 720555000446 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 720555000447 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 720555000448 Helix-hairpin-helix motif; Region: HHH; pfam00633 720555000449 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 720555000450 Dimer interface [polypeptide binding]; other site 720555000451 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 720555000452 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 720555000453 putative dimer interface [polypeptide binding]; other site 720555000454 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 720555000455 putative dimer interface [polypeptide binding]; other site 720555000456 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 720555000457 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 720555000458 active site 720555000459 ATP binding site [chemical binding]; other site 720555000460 substrate binding site [chemical binding]; other site 720555000461 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 720555000462 MgtC family; Region: MgtC; pfam02308 720555000463 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 720555000464 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 720555000465 Na binding site [ion binding]; other site 720555000466 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 720555000467 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 720555000468 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 720555000469 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 720555000470 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 720555000471 GatB domain; Region: GatB_Yqey; pfam02637 720555000472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555000473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555000474 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 720555000475 Protein export membrane protein; Region: SecD_SecF; cl14618 720555000476 Protein export membrane protein; Region: SecD_SecF; cl14618 720555000477 putative lipid kinase; Reviewed; Region: PRK13337 720555000478 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 720555000479 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 720555000480 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 720555000481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555000482 S-adenosylmethionine binding site [chemical binding]; other site 720555000483 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 720555000484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555000485 active site 720555000486 phosphorylation site [posttranslational modification] 720555000487 intermolecular recognition site; other site 720555000488 dimerization interface [polypeptide binding]; other site 720555000489 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 720555000490 DNA binding residues [nucleotide binding] 720555000491 dimerization interface [polypeptide binding]; other site 720555000492 acyl carrier protein; Provisional; Region: acpP; PRK00982 720555000493 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 720555000494 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 720555000495 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 720555000496 dimer interface [polypeptide binding]; other site 720555000497 active site 720555000498 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 720555000499 active site 720555000500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555000501 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 720555000502 NAD(P) binding site [chemical binding]; other site 720555000503 active site 720555000504 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 720555000505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555000506 Walker A/P-loop; other site 720555000507 ATP binding site [chemical binding]; other site 720555000508 Q-loop/lid; other site 720555000509 ABC transporter signature motif; other site 720555000510 Walker B; other site 720555000511 D-loop; other site 720555000512 H-loop/switch region; other site 720555000513 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 720555000514 Protein of unknown function, DUF600; Region: DUF600; cl04640 720555000515 Protein of unknown function, DUF600; Region: DUF600; pfam04634 720555000516 Protein required for attachment to host cells; Region: Host_attach; cl02398 720555000517 potential frameshift: common BLAST hit: gi|154685635|ref|YP_001420796.1| YqcG 720555000518 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555000519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555000520 TPR motif; other site 720555000521 binding surface 720555000522 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 720555000523 Phosphotransferase enzyme family; Region: APH; pfam01636 720555000524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555000525 binding surface 720555000526 TPR motif; other site 720555000527 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555000528 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555000529 hypothetical protein; Provisional; Region: PRK12378 720555000530 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 720555000531 CotJB protein; Region: CotJB; pfam12652 720555000532 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 720555000533 dimanganese center [ion binding]; other site 720555000534 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 720555000535 Coenzyme A binding pocket [chemical binding]; other site 720555000536 YesK-like protein; Region: YesK; pfam14150 720555000537 Predicted integral membrane protein [Function unknown]; Region: COG5578 720555000538 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 720555000539 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 720555000540 dimerization interface [polypeptide binding]; other site 720555000541 Histidine kinase; Region: His_kinase; pfam06580 720555000542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555000543 ATP binding site [chemical binding]; other site 720555000544 Mg2+ binding site [ion binding]; other site 720555000545 G-X-G motif; other site 720555000546 Response regulator receiver domain; Region: Response_reg; pfam00072 720555000547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555000548 active site 720555000549 phosphorylation site [posttranslational modification] 720555000550 intermolecular recognition site; other site 720555000551 dimerization interface [polypeptide binding]; other site 720555000552 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 720555000553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 720555000554 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 720555000555 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 720555000556 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 720555000557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555000558 dimer interface [polypeptide binding]; other site 720555000559 conserved gate region; other site 720555000560 putative PBP binding loops; other site 720555000561 ABC-ATPase subunit interface; other site 720555000562 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 720555000563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555000564 dimer interface [polypeptide binding]; other site 720555000565 conserved gate region; other site 720555000566 putative PBP binding loops; other site 720555000567 ABC-ATPase subunit interface; other site 720555000568 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 720555000569 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 720555000570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 720555000571 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 720555000572 active site 720555000573 catalytic triad [active] 720555000574 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 720555000575 Predicted integral membrane protein [Function unknown]; Region: COG5578 720555000576 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 720555000577 metal binding site [ion binding]; metal-binding site 720555000578 active site 720555000579 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 720555000580 metal binding site [ion binding]; metal-binding site 720555000581 active site 720555000582 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 720555000583 active site 720555000584 catalytic triad [active] 720555000585 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 720555000586 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 720555000587 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 720555000588 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 720555000589 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 720555000590 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 720555000591 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 720555000592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 720555000593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555000594 putative PBP binding loops; other site 720555000595 dimer interface [polypeptide binding]; other site 720555000596 ABC-ATPase subunit interface; other site 720555000597 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 720555000598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555000599 dimer interface [polypeptide binding]; other site 720555000600 conserved gate region; other site 720555000601 putative PBP binding loops; other site 720555000602 ABC-ATPase subunit interface; other site 720555000603 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 720555000604 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 720555000605 NAD(P) binding site [chemical binding]; other site 720555000606 LDH/MDH dimer interface [polypeptide binding]; other site 720555000607 substrate binding site [chemical binding]; other site 720555000608 Predicted membrane protein [Function unknown]; Region: COG2323 720555000609 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 720555000610 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555000611 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 720555000612 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 720555000613 Uncharacterized small protein [Function unknown]; Region: COG5583 720555000614 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 720555000615 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 720555000616 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 720555000617 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 720555000618 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 720555000619 Cytochrome P450; Region: p450; pfam00067 720555000620 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 720555000621 Flavodoxin; Region: Flavodoxin_1; pfam00258 720555000622 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 720555000623 FAD binding pocket [chemical binding]; other site 720555000624 FAD binding motif [chemical binding]; other site 720555000625 catalytic residues [active] 720555000626 NAD binding pocket [chemical binding]; other site 720555000627 phosphate binding motif [ion binding]; other site 720555000628 beta-alpha-beta structure motif; other site 720555000629 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 720555000630 Transcriptional regulators [Transcription]; Region: MarR; COG1846 720555000631 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 720555000632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555000633 Walker A/P-loop; other site 720555000634 ATP binding site [chemical binding]; other site 720555000635 Q-loop/lid; other site 720555000636 ABC transporter signature motif; other site 720555000637 Walker B; other site 720555000638 D-loop; other site 720555000639 H-loop/switch region; other site 720555000640 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 720555000641 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 720555000642 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 720555000643 Sulfatase; Region: Sulfatase; pfam00884 720555000644 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 720555000645 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 720555000646 substrate binding site; other site 720555000647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555000648 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 720555000649 NAD(P) binding site [chemical binding]; other site 720555000650 active site 720555000651 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 720555000652 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 720555000653 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 720555000654 active site 720555000655 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 720555000656 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555000657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000658 putative substrate translocation pore; other site 720555000659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000660 amino acid transporter; Region: 2A0306; TIGR00909 720555000661 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 720555000662 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 720555000663 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 720555000664 NAD(P) binding site [chemical binding]; other site 720555000665 catalytic residues [active] 720555000666 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 720555000667 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 720555000668 dimer interface [polypeptide binding]; other site 720555000669 putative CheW interface [polypeptide binding]; other site 720555000670 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 720555000671 putative metal binding site; other site 720555000672 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 720555000673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555000674 Walker A/P-loop; other site 720555000675 ATP binding site [chemical binding]; other site 720555000676 Q-loop/lid; other site 720555000677 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555000678 ABC transporter signature motif; other site 720555000679 Walker B; other site 720555000680 D-loop; other site 720555000681 ABC transporter; Region: ABC_tran_2; pfam12848 720555000682 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555000683 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 720555000684 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 720555000685 DNA binding residues [nucleotide binding] 720555000686 putative dimer interface [polypeptide binding]; other site 720555000687 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 720555000688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000689 putative substrate translocation pore; other site 720555000690 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 720555000691 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 720555000692 Coenzyme A binding pocket [chemical binding]; other site 720555000693 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 720555000694 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555000695 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555000696 ABC transporter; Region: ABC_tran_2; pfam12848 720555000697 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555000698 DEAD-like helicases superfamily; Region: DEXDc; smart00487 720555000699 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 720555000700 ATP binding site [chemical binding]; other site 720555000701 Mg++ binding site [ion binding]; other site 720555000702 motif III; other site 720555000703 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555000704 nucleotide binding region [chemical binding]; other site 720555000705 ATP-binding site [chemical binding]; other site 720555000706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555000707 TPR motif; other site 720555000708 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555000709 binding surface 720555000710 Prostaglandin dehydrogenases; Region: PGDH; cd05288 720555000711 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 720555000712 NAD(P) binding site [chemical binding]; other site 720555000713 substrate binding site [chemical binding]; other site 720555000714 dimer interface [polypeptide binding]; other site 720555000715 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 720555000716 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 720555000717 Walker A/P-loop; other site 720555000718 ATP binding site [chemical binding]; other site 720555000719 Q-loop/lid; other site 720555000720 ABC transporter signature motif; other site 720555000721 Walker B; other site 720555000722 D-loop; other site 720555000723 H-loop/switch region; other site 720555000724 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 720555000725 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555000726 ABC-ATPase subunit interface; other site 720555000727 dimer interface [polypeptide binding]; other site 720555000728 putative PBP binding regions; other site 720555000729 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 720555000730 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555000731 ABC-ATPase subunit interface; other site 720555000732 dimer interface [polypeptide binding]; other site 720555000733 putative PBP binding regions; other site 720555000734 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 720555000735 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 720555000736 siderophore binding site; other site 720555000737 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 720555000738 Heat induced stress protein YflT; Region: YflT; pfam11181 720555000739 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 720555000740 Amb_all domain; Region: Amb_all; smart00656 720555000741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555000742 Coenzyme A binding pocket [chemical binding]; other site 720555000743 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 720555000744 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 720555000745 transmembrane helices; other site 720555000746 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 720555000747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555000748 ATP binding site [chemical binding]; other site 720555000749 Mg2+ binding site [ion binding]; other site 720555000750 G-X-G motif; other site 720555000751 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 720555000752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555000753 active site 720555000754 phosphorylation site [posttranslational modification] 720555000755 intermolecular recognition site; other site 720555000756 dimerization interface [polypeptide binding]; other site 720555000757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 720555000758 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 720555000759 Citrate transporter; Region: CitMHS; pfam03600 720555000760 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 720555000761 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 720555000762 active site 720555000763 dimer interface [polypeptide binding]; other site 720555000764 Acylphosphatase; Region: Acylphosphatase; cl00551 720555000765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 720555000766 MOSC domain; Region: MOSC; pfam03473 720555000767 3-alpha domain; Region: 3-alpha; pfam03475 720555000768 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 720555000769 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 720555000770 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 720555000771 active site 720555000772 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 720555000773 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 720555000774 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 720555000775 active site turn [active] 720555000776 phosphorylation site [posttranslational modification] 720555000777 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 720555000778 Sulfatase; Region: Sulfatase; pfam00884 720555000779 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 720555000780 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 720555000781 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 720555000782 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 720555000783 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 720555000784 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 720555000785 active site turn [active] 720555000786 phosphorylation site [posttranslational modification] 720555000787 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 720555000788 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 720555000789 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 720555000790 Ca binding site [ion binding]; other site 720555000791 active site 720555000792 catalytic site [active] 720555000793 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 720555000794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555000795 DNA-binding site [nucleotide binding]; DNA binding site 720555000796 UTRA domain; Region: UTRA; pfam07702 720555000797 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 720555000798 dimer interface [polypeptide binding]; other site 720555000799 FMN binding site [chemical binding]; other site 720555000800 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 720555000801 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 720555000802 active site 720555000803 metal binding site [ion binding]; metal-binding site 720555000804 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 720555000805 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 720555000806 active site 720555000807 metal binding site [ion binding]; metal-binding site 720555000808 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 720555000809 intracellular protease, PfpI family; Region: PfpI; TIGR01382 720555000810 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 720555000811 proposed catalytic triad [active] 720555000812 conserved cys residue [active] 720555000813 Transcriptional regulators [Transcription]; Region: PurR; COG1609 720555000814 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 720555000815 DNA binding site [nucleotide binding] 720555000816 domain linker motif; other site 720555000817 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 720555000818 putative dimerization interface [polypeptide binding]; other site 720555000819 putative ligand binding site [chemical binding]; other site 720555000820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000821 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555000822 putative substrate translocation pore; other site 720555000823 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 720555000824 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 720555000825 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 720555000826 shikimate binding site; other site 720555000827 NAD(P) binding site [chemical binding]; other site 720555000828 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 720555000829 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 720555000830 active site 720555000831 catalytic residue [active] 720555000832 dimer interface [polypeptide binding]; other site 720555000833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000834 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555000835 putative substrate translocation pore; other site 720555000836 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 720555000837 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 720555000838 Low molecular weight phosphatase family; Region: LMWPc; cd00115 720555000839 active site 720555000840 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 720555000841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000842 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555000843 putative substrate translocation pore; other site 720555000844 calcium/proton exchanger (cax); Region: cax; TIGR00378 720555000845 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 720555000846 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 720555000847 YfkD-like protein; Region: YfkD; pfam14167 720555000848 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 720555000849 Mechanosensitive ion channel; Region: MS_channel; pfam00924 720555000850 Radical SAM superfamily; Region: Radical_SAM; pfam04055 720555000851 YfkB-like domain; Region: YfkB; pfam08756 720555000852 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 720555000853 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 720555000854 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 720555000855 NodB motif; other site 720555000856 active site 720555000857 catalytic site [active] 720555000858 Cd binding site [ion binding]; other site 720555000859 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 720555000860 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 720555000861 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 720555000862 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 720555000863 oligomer interface [polypeptide binding]; other site 720555000864 metal binding site [ion binding]; metal-binding site 720555000865 metal binding site [ion binding]; metal-binding site 720555000866 putative Cl binding site [ion binding]; other site 720555000867 aspartate ring; other site 720555000868 basic sphincter; other site 720555000869 hydrophobic gate; other site 720555000870 periplasmic entrance; other site 720555000871 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 720555000872 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 720555000873 minor groove reading motif; other site 720555000874 helix-hairpin-helix signature motif; other site 720555000875 substrate binding pocket [chemical binding]; other site 720555000876 active site 720555000877 TRAM domain; Region: TRAM; pfam01938 720555000878 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 720555000879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555000880 S-adenosylmethionine binding site [chemical binding]; other site 720555000881 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 720555000882 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 720555000883 FMN binding site [chemical binding]; other site 720555000884 active site 720555000885 catalytic residues [active] 720555000886 substrate binding site [chemical binding]; other site 720555000887 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 720555000888 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 720555000889 tetramer interface [polypeptide binding]; other site 720555000890 TPP-binding site [chemical binding]; other site 720555000891 heterodimer interface [polypeptide binding]; other site 720555000892 phosphorylation loop region [posttranslational modification] 720555000893 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 720555000894 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 720555000895 alpha subunit interface [polypeptide binding]; other site 720555000896 TPP binding site [chemical binding]; other site 720555000897 heterodimer interface [polypeptide binding]; other site 720555000898 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 720555000899 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 720555000900 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 720555000901 E3 interaction surface; other site 720555000902 lipoyl attachment site [posttranslational modification]; other site 720555000903 e3 binding domain; Region: E3_binding; pfam02817 720555000904 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 720555000905 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 720555000906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555000907 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 720555000908 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 720555000909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555000910 Walker A motif; other site 720555000911 ATP binding site [chemical binding]; other site 720555000912 Walker B motif; other site 720555000913 arginine finger; other site 720555000914 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 720555000915 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 720555000916 hypothetical protein; Provisional; Region: PRK02237 720555000917 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 720555000918 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 720555000919 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 720555000920 NAD binding site [chemical binding]; other site 720555000921 sugar binding site [chemical binding]; other site 720555000922 divalent metal binding site [ion binding]; other site 720555000923 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 720555000924 dimer interface [polypeptide binding]; other site 720555000925 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 720555000926 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 720555000927 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 720555000928 putative active site [active] 720555000929 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 720555000930 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 720555000931 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 720555000932 active site turn [active] 720555000933 phosphorylation site [posttranslational modification] 720555000934 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 720555000935 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 720555000936 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 720555000937 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 720555000938 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 720555000939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555000940 Walker A/P-loop; other site 720555000941 ATP binding site [chemical binding]; other site 720555000942 Q-loop/lid; other site 720555000943 ABC transporter signature motif; other site 720555000944 Walker B; other site 720555000945 D-loop; other site 720555000946 H-loop/switch region; other site 720555000947 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 720555000948 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 720555000949 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 720555000950 Walker A/P-loop; other site 720555000951 ATP binding site [chemical binding]; other site 720555000952 Q-loop/lid; other site 720555000953 ABC transporter signature motif; other site 720555000954 Walker B; other site 720555000955 D-loop; other site 720555000956 H-loop/switch region; other site 720555000957 Predicted membrane protein [Function unknown]; Region: COG2259 720555000958 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 720555000959 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 720555000960 putative metal binding site [ion binding]; other site 720555000961 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 720555000962 active site 720555000963 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 720555000964 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 720555000965 Predicted transcriptional regulators [Transcription]; Region: COG1695 720555000966 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 720555000967 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 720555000968 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 720555000969 Acyltransferase family; Region: Acyl_transf_3; pfam01757 720555000970 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 720555000971 RNAase interaction site [polypeptide binding]; other site 720555000972 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 720555000973 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 720555000974 putative NAD(P) binding site [chemical binding]; other site 720555000975 dimer interface [polypeptide binding]; other site 720555000976 metal-dependent hydrolase; Provisional; Region: PRK13291 720555000977 DinB superfamily; Region: DinB_2; pfam12867 720555000978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000979 putative substrate translocation pore; other site 720555000980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555000981 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555000982 MarR family; Region: MarR; pfam01047 720555000983 Predicted integral membrane protein [Function unknown]; Region: COG0392 720555000984 Uncharacterized conserved protein [Function unknown]; Region: COG2898 720555000985 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 720555000986 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 720555000987 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 720555000988 siderophore binding site; other site 720555000989 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 720555000990 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555000991 ABC-ATPase subunit interface; other site 720555000992 dimer interface [polypeptide binding]; other site 720555000993 putative PBP binding regions; other site 720555000994 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 720555000995 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555000996 ABC-ATPase subunit interface; other site 720555000997 dimer interface [polypeptide binding]; other site 720555000998 putative PBP binding regions; other site 720555000999 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 720555001000 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 720555001001 putative FMN binding site [chemical binding]; other site 720555001002 YfhD-like protein; Region: YfhD; pfam14151 720555001003 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 720555001004 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 720555001005 putative NAD(P) binding site [chemical binding]; other site 720555001006 putative active site [active] 720555001007 recombination regulator RecX; Provisional; Region: recX; PRK14135 720555001008 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 720555001009 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 720555001010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555001011 putative substrate translocation pore; other site 720555001012 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 720555001013 WVELL protein; Region: WVELL; pfam14043 720555001014 Bacterial SH3 domain; Region: SH3_3; pfam08239 720555001015 SdpI/YhfL protein family; Region: SdpI; pfam13630 720555001016 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 720555001017 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 720555001018 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 720555001019 Ligand binding site; other site 720555001020 Putative Catalytic site; other site 720555001021 DXD motif; other site 720555001022 Predicted membrane protein [Function unknown]; Region: COG4485 720555001023 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 720555001024 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 720555001025 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 720555001026 minor groove reading motif; other site 720555001027 helix-hairpin-helix signature motif; other site 720555001028 substrate binding pocket [chemical binding]; other site 720555001029 active site 720555001030 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 720555001031 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 720555001032 DNA binding and oxoG recognition site [nucleotide binding] 720555001033 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 720555001034 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 720555001035 putative NAD(P) binding site [chemical binding]; other site 720555001036 active site 720555001037 YgaB-like protein; Region: YgaB; pfam14182 720555001038 hypothetical protein; Provisional; Region: PRK13662 720555001039 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 720555001040 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 720555001041 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 720555001042 Walker A/P-loop; other site 720555001043 ATP binding site [chemical binding]; other site 720555001044 Q-loop/lid; other site 720555001045 ABC transporter signature motif; other site 720555001046 Walker B; other site 720555001047 D-loop; other site 720555001048 H-loop/switch region; other site 720555001049 Predicted membrane protein [Function unknown]; Region: COG4129 720555001050 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 720555001051 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 720555001052 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 720555001053 inhibitor-cofactor binding pocket; inhibition site 720555001054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555001055 catalytic residue [active] 720555001056 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 720555001057 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 720555001058 catalytic triad [active] 720555001059 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 720555001060 metal binding site 2 [ion binding]; metal-binding site 720555001061 putative DNA binding helix; other site 720555001062 metal binding site 1 [ion binding]; metal-binding site 720555001063 dimer interface [polypeptide binding]; other site 720555001064 structural Zn2+ binding site [ion binding]; other site 720555001065 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 720555001066 potential protein location (hypothetical protein BATR1942_01960 [Bacillus atrophaeus 1942]) that overlaps RNA (tRNA-W) 720555001067 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 720555001068 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 720555001069 NAD binding site [chemical binding]; other site 720555001070 catalytic Zn binding site [ion binding]; other site 720555001071 structural Zn binding site [ion binding]; other site 720555001072 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 720555001073 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 720555001074 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 720555001075 active site pocket [active] 720555001076 oxyanion hole [active] 720555001077 catalytic triad [active] 720555001078 active site nucleophile [active] 720555001079 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 720555001080 ThiC-associated domain; Region: ThiC-associated; pfam13667 720555001081 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 720555001082 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 720555001083 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 720555001084 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 720555001085 tetramer interface [polypeptide binding]; other site 720555001086 heme binding pocket [chemical binding]; other site 720555001087 NADPH binding site [chemical binding]; other site 720555001088 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 720555001089 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 720555001090 Walker A/P-loop; other site 720555001091 ATP binding site [chemical binding]; other site 720555001092 Q-loop/lid; other site 720555001093 ABC transporter signature motif; other site 720555001094 Walker B; other site 720555001095 D-loop; other site 720555001096 H-loop/switch region; other site 720555001097 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 720555001098 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 720555001099 substrate binding pocket [chemical binding]; other site 720555001100 membrane-bound complex binding site; other site 720555001101 hinge residues; other site 720555001102 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 720555001103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 720555001104 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 720555001105 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 720555001106 active site 720555001107 dimer interface [polypeptide binding]; other site 720555001108 non-prolyl cis peptide bond; other site 720555001109 insertion regions; other site 720555001110 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 720555001111 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 720555001112 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 720555001113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555001114 non-specific DNA binding site [nucleotide binding]; other site 720555001115 salt bridge; other site 720555001116 sequence-specific DNA binding site [nucleotide binding]; other site 720555001117 potential protein location (hypothetical protein BATR1942_02040 [Bacillus atrophaeus 1942]) that overlaps RNA (tRNA-G) 720555001118 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 720555001119 B3/4 domain; Region: B3_4; pfam03483 720555001120 epoxyqueuosine reductase; Region: TIGR00276 720555001121 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 720555001122 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 720555001123 Putative amidase domain; Region: Amidase_6; pfam12671 720555001124 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 720555001125 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 720555001126 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 720555001127 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 720555001128 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 720555001129 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 720555001130 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 720555001131 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 720555001132 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555001133 MarR family; Region: MarR; pfam01047 720555001134 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 720555001135 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 720555001136 carboxyltransferase (CT) interaction site; other site 720555001137 biotinylation site [posttranslational modification]; other site 720555001138 HlyD family secretion protein; Region: HlyD_3; pfam13437 720555001139 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 720555001140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555001141 putative substrate translocation pore; other site 720555001142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555001143 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 720555001144 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 720555001145 Predicted transcriptional regulators [Transcription]; Region: COG1725 720555001146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555001147 DNA-binding site [nucleotide binding]; DNA binding site 720555001148 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 720555001149 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 720555001150 Walker A/P-loop; other site 720555001151 ATP binding site [chemical binding]; other site 720555001152 Q-loop/lid; other site 720555001153 ABC transporter signature motif; other site 720555001154 Walker B; other site 720555001155 D-loop; other site 720555001156 H-loop/switch region; other site 720555001157 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 720555001158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555001159 Walker A/P-loop; other site 720555001160 ATP binding site [chemical binding]; other site 720555001161 Q-loop/lid; other site 720555001162 ABC transporter signature motif; other site 720555001163 Walker B; other site 720555001164 D-loop; other site 720555001165 H-loop/switch region; other site 720555001166 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 720555001167 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 720555001168 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 720555001169 DNA-binding site [nucleotide binding]; DNA binding site 720555001170 RNA-binding motif; other site 720555001171 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 720555001172 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 720555001173 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 720555001174 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 720555001175 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 720555001176 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 720555001177 metal binding site [ion binding]; metal-binding site 720555001178 active site 720555001179 I-site; other site 720555001180 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 720555001181 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 720555001182 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 720555001183 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 720555001184 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 720555001185 CheB methylesterase; Region: CheB_methylest; pfam01339 720555001186 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 720555001187 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 720555001188 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 720555001189 PAS domain; Region: PAS_10; pfam13596 720555001190 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 720555001191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555001192 putative active site [active] 720555001193 heme pocket [chemical binding]; other site 720555001194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555001195 dimer interface [polypeptide binding]; other site 720555001196 phosphorylation site [posttranslational modification] 720555001197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555001198 ATP binding site [chemical binding]; other site 720555001199 Mg2+ binding site [ion binding]; other site 720555001200 G-X-G motif; other site 720555001201 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 720555001202 generic binding surface II; other site 720555001203 generic binding surface I; other site 720555001204 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 720555001205 generic binding surface II; other site 720555001206 generic binding surface I; other site 720555001207 Staphylococcal nuclease homologues; Region: SNc; smart00318 720555001208 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 720555001209 Catalytic site; other site 720555001210 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 720555001211 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 720555001212 putative active site [active] 720555001213 putative metal binding site [ion binding]; other site 720555001214 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 720555001215 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 720555001216 active site 720555001217 catalytic site [active] 720555001218 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 720555001219 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 720555001220 RNA binding surface [nucleotide binding]; other site 720555001221 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 720555001222 active site 720555001223 FOG: CBS domain [General function prediction only]; Region: COG0517 720555001224 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 720555001225 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 720555001226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555001227 motif II; other site 720555001228 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 720555001229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555001230 Coenzyme A binding pocket [chemical binding]; other site 720555001231 Predicted amidohydrolase [General function prediction only]; Region: COG0388 720555001232 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 720555001233 putative active site [active] 720555001234 catalytic triad [active] 720555001235 putative dimer interface [polypeptide binding]; other site 720555001236 Predicted permeases [General function prediction only]; Region: COG0679 720555001237 aminotransferase; Validated; Region: PRK07678 720555001238 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 720555001239 inhibitor-cofactor binding pocket; inhibition site 720555001240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555001241 catalytic residue [active] 720555001242 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 720555001243 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 720555001244 amphipathic channel; other site 720555001245 Asn-Pro-Ala signature motifs; other site 720555001246 glycerol kinase; Provisional; Region: glpK; PRK00047 720555001247 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 720555001248 N- and C-terminal domain interface [polypeptide binding]; other site 720555001249 active site 720555001250 MgATP binding site [chemical binding]; other site 720555001251 catalytic site [active] 720555001252 metal binding site [ion binding]; metal-binding site 720555001253 glycerol binding site [chemical binding]; other site 720555001254 homotetramer interface [polypeptide binding]; other site 720555001255 homodimer interface [polypeptide binding]; other site 720555001256 FBP binding site [chemical binding]; other site 720555001257 protein IIAGlc interface [polypeptide binding]; other site 720555001258 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 720555001259 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 720555001260 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 720555001261 active site 720555001262 substrate binding site [chemical binding]; other site 720555001263 metal binding site [ion binding]; metal-binding site 720555001264 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 720555001265 GAF domain; Region: GAF; pfam01590 720555001266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 720555001267 Histidine kinase; Region: HisKA_3; pfam07730 720555001268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555001269 ATP binding site [chemical binding]; other site 720555001270 Mg2+ binding site [ion binding]; other site 720555001271 G-X-G motif; other site 720555001272 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 720555001273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555001274 active site 720555001275 phosphorylation site [posttranslational modification] 720555001276 intermolecular recognition site; other site 720555001277 dimerization interface [polypeptide binding]; other site 720555001278 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 720555001279 DNA binding residues [nucleotide binding] 720555001280 dimerization interface [polypeptide binding]; other site 720555001281 Predicted flavoprotein [General function prediction only]; Region: COG0431 720555001282 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 720555001283 YhdB-like protein; Region: YhdB; pfam14148 720555001284 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 720555001285 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555001286 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555001287 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 720555001288 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555001289 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555001290 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555001291 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 720555001292 NlpC/P60 family; Region: NLPC_P60; pfam00877 720555001293 Transcriptional regulator; Region: Rrf2; cl17282 720555001294 Rrf2 family protein; Region: rrf2_super; TIGR00738 720555001295 Conserved TM helix; Region: TM_helix; pfam05552 720555001296 Conserved TM helix; Region: TM_helix; pfam05552 720555001297 Conserved TM helix; Region: TM_helix; pfam05552 720555001298 Conserved TM helix; Region: TM_helix; pfam05552 720555001299 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 720555001300 SpoVR like protein; Region: SpoVR; pfam04293 720555001301 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 720555001302 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 720555001303 active site 720555001304 dimer interface [polypeptide binding]; other site 720555001305 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555001306 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555001307 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 720555001308 NlpC/P60 family; Region: NLPC_P60; pfam00877 720555001309 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555001310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555001311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 720555001312 dimerization interface [polypeptide binding]; other site 720555001313 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 720555001314 dimer interface [polypeptide binding]; other site 720555001315 Citrate synthase; Region: Citrate_synt; pfam00285 720555001316 active site 720555001317 citrylCoA binding site [chemical binding]; other site 720555001318 oxalacetate/citrate binding site [chemical binding]; other site 720555001319 coenzyme A binding site [chemical binding]; other site 720555001320 catalytic triad [active] 720555001321 short chain dehydrogenase; Provisional; Region: PRK06701 720555001322 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 720555001323 NAD binding site [chemical binding]; other site 720555001324 metal binding site [ion binding]; metal-binding site 720555001325 active site 720555001326 amino acid transporter; Region: 2A0306; TIGR00909 720555001327 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 720555001328 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 720555001329 Na2 binding site [ion binding]; other site 720555001330 putative substrate binding site 1 [chemical binding]; other site 720555001331 Na binding site 1 [ion binding]; other site 720555001332 putative substrate binding site 2 [chemical binding]; other site 720555001333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 720555001334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555001335 Coenzyme A binding pocket [chemical binding]; other site 720555001336 S-methylmethionine transporter; Provisional; Region: PRK11387 720555001337 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 720555001338 putative metal binding site [ion binding]; other site 720555001339 putative dimer interface [polypeptide binding]; other site 720555001340 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 720555001341 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 720555001342 Glutamate binding site [chemical binding]; other site 720555001343 homodimer interface [polypeptide binding]; other site 720555001344 NAD binding site [chemical binding]; other site 720555001345 catalytic residues [active] 720555001346 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 720555001347 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 720555001348 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 720555001349 NAD(P) binding site [chemical binding]; other site 720555001350 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 720555001351 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 720555001352 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 720555001353 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555001354 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555001355 DNA binding residues [nucleotide binding] 720555001356 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 720555001357 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 720555001358 active site 720555001359 catalytic tetrad [active] 720555001360 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 720555001361 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 720555001362 putative acyl-acceptor binding pocket; other site 720555001363 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 720555001364 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 720555001365 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 720555001366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555001367 NAD(P) binding site [chemical binding]; other site 720555001368 active site 720555001369 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 720555001370 Domain of unknown function DUF21; Region: DUF21; pfam01595 720555001371 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 720555001372 Transporter associated domain; Region: CorC_HlyC; smart01091 720555001373 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 720555001374 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 720555001375 DNA binding residues [nucleotide binding] 720555001376 putative dimer interface [polypeptide binding]; other site 720555001377 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 720555001378 Domain of unknown function DUF21; Region: DUF21; pfam01595 720555001379 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 720555001380 Transporter associated domain; Region: CorC_HlyC; smart01091 720555001381 CrcB-like protein; Region: CRCB; cl09114 720555001382 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 720555001383 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 720555001384 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 720555001385 active site 720555001386 catalytic site [active] 720555001387 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 720555001388 Mechanosensitive ion channel; Region: MS_channel; pfam00924 720555001389 NAD-dependent deacetylase; Provisional; Region: PRK00481 720555001390 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 720555001391 NAD+ binding site [chemical binding]; other site 720555001392 substrate binding site [chemical binding]; other site 720555001393 Zn binding site [ion binding]; other site 720555001394 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 720555001395 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 720555001396 NodB motif; other site 720555001397 active site 720555001398 catalytic site [active] 720555001399 Zn binding site [ion binding]; other site 720555001400 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 720555001401 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 720555001402 homodimer interface [polypeptide binding]; other site 720555001403 substrate-cofactor binding pocket; other site 720555001404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555001405 catalytic residue [active] 720555001406 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 720555001407 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 720555001408 Ligand Binding Site [chemical binding]; other site 720555001409 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 720555001410 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 720555001411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555001412 Walker A/P-loop; other site 720555001413 ATP binding site [chemical binding]; other site 720555001414 Q-loop/lid; other site 720555001415 ABC transporter signature motif; other site 720555001416 Walker B; other site 720555001417 D-loop; other site 720555001418 H-loop/switch region; other site 720555001419 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 720555001420 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 720555001421 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 720555001422 Walker A/P-loop; other site 720555001423 ATP binding site [chemical binding]; other site 720555001424 Q-loop/lid; other site 720555001425 ABC transporter signature motif; other site 720555001426 Walker B; other site 720555001427 D-loop; other site 720555001428 H-loop/switch region; other site 720555001429 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 720555001430 NADH(P)-binding; Region: NAD_binding_10; pfam13460 720555001431 NAD binding site [chemical binding]; other site 720555001432 substrate binding site [chemical binding]; other site 720555001433 putative active site [active] 720555001434 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 720555001435 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 720555001436 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 720555001437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 720555001438 hypothetical protein; Provisional; Region: PRK13676 720555001439 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 720555001440 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 720555001441 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 720555001442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555001443 active site 720555001444 motif I; other site 720555001445 motif II; other site 720555001446 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 720555001447 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 720555001448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 720555001449 FeS/SAM binding site; other site 720555001450 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 720555001451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 720555001452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 720555001453 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 720555001454 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 720555001455 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 720555001456 TrkA-C domain; Region: TrkA_C; pfam02080 720555001457 enoyl-CoA hydratase; Provisional; Region: PRK07659 720555001458 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 720555001459 substrate binding site [chemical binding]; other site 720555001460 oxyanion hole (OAH) forming residues; other site 720555001461 trimer interface [polypeptide binding]; other site 720555001462 YhzD-like protein; Region: YhzD; pfam14120 720555001463 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 720555001464 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 720555001465 Walker A/P-loop; other site 720555001466 ATP binding site [chemical binding]; other site 720555001467 Q-loop/lid; other site 720555001468 ABC transporter signature motif; other site 720555001469 Walker B; other site 720555001470 D-loop; other site 720555001471 H-loop/switch region; other site 720555001472 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 720555001473 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 720555001474 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 720555001475 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 720555001476 active site 720555001477 metal binding site [ion binding]; metal-binding site 720555001478 DNA binding site [nucleotide binding] 720555001479 Uncharacterized conserved protein [Function unknown]; Region: COG4717 720555001480 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 720555001481 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 720555001482 generic binding surface II; other site 720555001483 generic binding surface I; other site 720555001484 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 720555001485 Zn2+ binding site [ion binding]; other site 720555001486 Mg2+ binding site [ion binding]; other site 720555001487 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 720555001488 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 720555001489 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 720555001490 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 720555001491 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 720555001492 transcriptional regulator Hpr; Provisional; Region: PRK13777 720555001493 MarR family; Region: MarR; pfam01047 720555001494 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 720555001495 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 720555001496 homodimer interface [polypeptide binding]; other site 720555001497 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 720555001498 substrate-cofactor binding pocket; other site 720555001499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555001500 catalytic residue [active] 720555001501 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 720555001502 HIT family signature motif; other site 720555001503 catalytic residue [active] 720555001504 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 720555001505 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 720555001506 Walker A/P-loop; other site 720555001507 ATP binding site [chemical binding]; other site 720555001508 Q-loop/lid; other site 720555001509 ABC transporter signature motif; other site 720555001510 Walker B; other site 720555001511 D-loop; other site 720555001512 H-loop/switch region; other site 720555001513 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 720555001514 EcsC protein family; Region: EcsC; pfam12787 720555001515 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 720555001516 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 720555001517 metal binding site [ion binding]; metal-binding site 720555001518 dimer interface [polypeptide binding]; other site 720555001519 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 720555001520 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 720555001521 Transglycosylase; Region: Transgly; pfam00912 720555001522 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 720555001523 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 720555001524 substrate binding site [chemical binding]; other site 720555001525 active site 720555001526 ferrochelatase; Provisional; Region: PRK12435 720555001527 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 720555001528 C-terminal domain interface [polypeptide binding]; other site 720555001529 active site 720555001530 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 720555001531 active site 720555001532 N-terminal domain interface [polypeptide binding]; other site 720555001533 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 720555001534 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 720555001535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555001536 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555001537 Predicted membrane protein [Function unknown]; Region: COG1511 720555001538 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 720555001539 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 720555001540 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 720555001541 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 720555001542 dimer interface [polypeptide binding]; other site 720555001543 active site 720555001544 CoA binding pocket [chemical binding]; other site 720555001545 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 720555001546 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 720555001547 putative oligomer interface [polypeptide binding]; other site 720555001548 putative active site [active] 720555001549 metal binding site [ion binding]; metal-binding site 720555001550 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 720555001551 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 720555001552 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 720555001553 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 720555001554 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 720555001555 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 720555001556 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 720555001557 NADH(P)-binding; Region: NAD_binding_10; pfam13460 720555001558 NAD(P) binding site [chemical binding]; other site 720555001559 putative active site [active] 720555001560 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 720555001561 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 720555001562 acyl-activating enzyme (AAE) consensus motif; other site 720555001563 putative AMP binding site [chemical binding]; other site 720555001564 putative active site [active] 720555001565 putative CoA binding site [chemical binding]; other site 720555001566 DHHC palmitoyltransferase; Region: zf-DHHC; pfam01529 720555001567 Peptidase family M48; Region: Peptidase_M48; pfam01435 720555001568 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 720555001569 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 720555001570 active site 720555001571 catalytic residues [active] 720555001572 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 720555001573 Coenzyme A binding pocket [chemical binding]; other site 720555001574 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 720555001575 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 720555001576 NAD(P) binding site [chemical binding]; other site 720555001577 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 720555001578 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 720555001579 siderophore binding site; other site 720555001580 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 720555001581 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555001582 ABC-ATPase subunit interface; other site 720555001583 dimer interface [polypeptide binding]; other site 720555001584 putative PBP binding regions; other site 720555001585 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 720555001586 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555001587 dimer interface [polypeptide binding]; other site 720555001588 putative PBP binding regions; other site 720555001589 ABC-ATPase subunit interface; other site 720555001590 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 720555001591 catalytic core [active] 720555001592 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 720555001593 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 720555001594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 720555001595 active site 720555001596 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 720555001597 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 720555001598 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 720555001599 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 720555001600 tetrameric interface [polypeptide binding]; other site 720555001601 NAD binding site [chemical binding]; other site 720555001602 catalytic residues [active] 720555001603 enoyl-CoA hydratase; Provisional; Region: PRK07658 720555001604 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 720555001605 substrate binding site [chemical binding]; other site 720555001606 oxyanion hole (OAH) forming residues; other site 720555001607 trimer interface [polypeptide binding]; other site 720555001608 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 720555001609 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 720555001610 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 720555001611 substrate binding site [chemical binding]; other site 720555001612 oxyanion hole (OAH) forming residues; other site 720555001613 trimer interface [polypeptide binding]; other site 720555001614 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 720555001615 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 720555001616 heme-binding site [chemical binding]; other site 720555001617 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 720555001618 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 720555001619 dimer interface [polypeptide binding]; other site 720555001620 putative CheW interface [polypeptide binding]; other site 720555001621 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 720555001622 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 720555001623 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 720555001624 [2Fe-2S] cluster binding site [ion binding]; other site 720555001625 short chain dehydrogenase; Provisional; Region: PRK06701 720555001626 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 720555001627 NAD binding site [chemical binding]; other site 720555001628 metal binding site [ion binding]; metal-binding site 720555001629 active site 720555001630 IDEAL domain; Region: IDEAL; pfam08858 720555001631 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 720555001632 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 720555001633 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 720555001634 Na binding site [ion binding]; other site 720555001635 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 720555001636 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 720555001637 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 720555001638 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 720555001639 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 720555001640 Catalytic site [active] 720555001641 hypothetical protein; Provisional; Region: PRK08244 720555001642 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 720555001643 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555001644 MarR family; Region: MarR; pfam01047 720555001645 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 720555001646 Putative ammonia monooxygenase; Region: AmoA; pfam05145 720555001647 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 720555001648 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 720555001649 dimerization interface [polypeptide binding]; other site 720555001650 Uncharacterized conserved protein [Function unknown]; Region: COG1633 720555001651 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 720555001652 dinuclear metal binding motif [ion binding]; other site 720555001653 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 720555001654 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 720555001655 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 720555001656 Part of AAA domain; Region: AAA_19; pfam13245 720555001657 Family description; Region: UvrD_C_2; pfam13538 720555001658 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 720555001659 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 720555001660 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 720555001661 active site 720555001662 metal binding site [ion binding]; metal-binding site 720555001663 DNA binding site [nucleotide binding] 720555001664 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 720555001665 exonuclease SbcC; Region: sbcc; TIGR00618 720555001666 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 720555001667 Walker A/P-loop; other site 720555001668 ATP binding site [chemical binding]; other site 720555001669 Q-loop/lid; other site 720555001670 ABC transporter signature motif; other site 720555001671 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 720555001672 ABC transporter signature motif; other site 720555001673 Walker B; other site 720555001674 D-loop; other site 720555001675 H-loop/switch region; other site 720555001676 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 720555001677 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 720555001678 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 720555001679 Spore germination protein GerPC; Region: GerPC; pfam10737 720555001680 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 720555001681 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 720555001682 Predicted membrane protein [Function unknown]; Region: COG2311 720555001683 Protein of unknown function (DUF418); Region: DUF418; pfam04235 720555001684 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 720555001685 CotH protein; Region: CotH; pfam08757 720555001686 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 720555001687 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 720555001688 hypothetical protein; Provisional; Region: PRK13673 720555001689 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 720555001690 active site 720555001691 catalytic triad [active] 720555001692 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 720555001693 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 720555001694 active site 720555001695 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 720555001696 dimer interface [polypeptide binding]; other site 720555001697 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 720555001698 Ligand Binding Site [chemical binding]; other site 720555001699 Molecular Tunnel; other site 720555001700 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 720555001701 active site lid residues [active] 720555001702 substrate binding pocket [chemical binding]; other site 720555001703 catalytic residues [active] 720555001704 aspartate-rich region 2; other site 720555001705 substrate-Mg2+ binding site; other site 720555001706 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 720555001707 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 720555001708 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 720555001709 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 720555001710 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 720555001711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 720555001712 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 720555001713 UbiA prenyltransferase family; Region: UbiA; pfam01040 720555001714 Transcriptional regulators [Transcription]; Region: PurR; COG1609 720555001715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 720555001716 DNA binding site [nucleotide binding] 720555001717 domain linker motif; other site 720555001718 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 720555001719 dimerization interface [polypeptide binding]; other site 720555001720 ligand binding site [chemical binding]; other site 720555001721 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 720555001722 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 720555001723 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 720555001724 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 720555001725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 720555001726 DinB superfamily; Region: DinB_2; pfam12867 720555001727 LysE type translocator; Region: LysE; cl00565 720555001728 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 720555001729 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555001730 catalytic residue [active] 720555001731 homodimer interface [polypeptide binding]; other site 720555001732 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 720555001733 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 720555001734 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 720555001735 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 720555001736 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 720555001737 TAP-like protein; Region: Abhydrolase_4; pfam08386 720555001738 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 720555001739 ligand-binding site [chemical binding]; other site 720555001740 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 720555001741 ATP-sulfurylase; Region: ATPS; cd00517 720555001742 active site 720555001743 HXXH motif; other site 720555001744 flexible loop; other site 720555001745 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 720555001746 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 720555001747 Active Sites [active] 720555001748 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 720555001749 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 720555001750 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 720555001751 Uncharacterized conserved protein [Function unknown]; Region: COG1284 720555001752 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 720555001753 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 720555001754 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 720555001755 active site pocket [active] 720555001756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555001757 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555001758 putative substrate translocation pore; other site 720555001759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 720555001760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555001761 Coenzyme A binding pocket [chemical binding]; other site 720555001762 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 720555001763 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 720555001764 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 720555001765 FAD binding site [chemical binding]; other site 720555001766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 720555001767 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 720555001768 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 720555001769 S1 domain; Region: S1_2; pfam13509 720555001770 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 720555001771 RNA binding site [nucleotide binding]; other site 720555001772 EDD domain protein, DegV family; Region: DegV; TIGR00762 720555001773 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 720555001774 Uncharacterized conserved protein [Function unknown]; Region: COG1284 720555001775 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 720555001776 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 720555001777 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 720555001778 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 720555001779 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 720555001780 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 720555001781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555001782 motif II; other site 720555001783 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 720555001784 esterase; Provisional; Region: PRK10566 720555001785 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 720555001786 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 720555001787 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 720555001788 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 720555001789 FAD binding domain; Region: FAD_binding_4; pfam01565 720555001790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555001791 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555001792 putative substrate translocation pore; other site 720555001793 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 720555001794 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 720555001795 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 720555001796 heterotetramer interface [polypeptide binding]; other site 720555001797 active site pocket [active] 720555001798 cleavage site 720555001799 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 720555001800 nucleotide binding site [chemical binding]; other site 720555001801 N-acetyl-L-glutamate binding site [chemical binding]; other site 720555001802 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 720555001803 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 720555001804 inhibitor-cofactor binding pocket; inhibition site 720555001805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555001806 catalytic residue [active] 720555001807 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 720555001808 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 720555001809 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 720555001810 catalytic site [active] 720555001811 subunit interface [polypeptide binding]; other site 720555001812 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 720555001813 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 720555001814 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 720555001815 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 720555001816 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 720555001817 ATP-grasp domain; Region: ATP-grasp_4; cl17255 720555001818 ornithine carbamoyltransferase; Provisional; Region: PRK00779 720555001819 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 720555001820 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 720555001821 YjzC-like protein; Region: YjzC; pfam14168 720555001822 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 720555001823 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 720555001824 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 720555001825 putative ligand binding site [chemical binding]; other site 720555001826 ComZ; Region: ComZ; pfam10815 720555001827 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 720555001828 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 720555001829 dimer interface [polypeptide binding]; other site 720555001830 active site 720555001831 CoA binding pocket [chemical binding]; other site 720555001832 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 720555001833 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 720555001834 dimer interface [polypeptide binding]; other site 720555001835 active site 720555001836 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 720555001837 potential frameshift: common BLAST hit: gi|16078201|ref|NP_389018.1| oligopeptide ABC transporter (ATP-binding protein) 720555001838 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 720555001839 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 720555001840 Walker A/P-loop; other site 720555001841 ATP binding site [chemical binding]; other site 720555001842 Q-loop/lid; other site 720555001843 ABC transporter signature motif; other site 720555001844 Walker B; other site 720555001845 D-loop; other site 720555001846 H-loop/switch region; other site 720555001847 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 720555001848 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 720555001849 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 720555001850 peptide binding site [polypeptide binding]; other site 720555001851 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 720555001852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555001853 dimer interface [polypeptide binding]; other site 720555001854 conserved gate region; other site 720555001855 putative PBP binding loops; other site 720555001856 ABC-ATPase subunit interface; other site 720555001857 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 720555001858 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 720555001859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555001860 dimer interface [polypeptide binding]; other site 720555001861 conserved gate region; other site 720555001862 putative PBP binding loops; other site 720555001863 ABC-ATPase subunit interface; other site 720555001864 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 720555001865 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 720555001866 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 720555001867 active site 720555001868 HIGH motif; other site 720555001869 dimer interface [polypeptide binding]; other site 720555001870 KMSKS motif; other site 720555001871 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 720555001872 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 720555001873 peptide binding site [polypeptide binding]; other site 720555001874 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 720555001875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555001876 dimer interface [polypeptide binding]; other site 720555001877 conserved gate region; other site 720555001878 putative PBP binding loops; other site 720555001879 ABC-ATPase subunit interface; other site 720555001880 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 720555001881 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 720555001882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555001883 dimer interface [polypeptide binding]; other site 720555001884 conserved gate region; other site 720555001885 putative PBP binding loops; other site 720555001886 ABC-ATPase subunit interface; other site 720555001887 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 720555001888 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 720555001889 Walker A/P-loop; other site 720555001890 ATP binding site [chemical binding]; other site 720555001891 Q-loop/lid; other site 720555001892 ABC transporter signature motif; other site 720555001893 Walker B; other site 720555001894 D-loop; other site 720555001895 H-loop/switch region; other site 720555001896 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 720555001897 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 720555001898 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 720555001899 Walker A/P-loop; other site 720555001900 ATP binding site [chemical binding]; other site 720555001901 Q-loop/lid; other site 720555001902 ABC transporter signature motif; other site 720555001903 Walker B; other site 720555001904 D-loop; other site 720555001905 H-loop/switch region; other site 720555001906 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 720555001907 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 720555001908 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 720555001909 ArsC family; Region: ArsC; pfam03960 720555001910 putative catalytic residues [active] 720555001911 thiol/disulfide switch; other site 720555001912 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 720555001913 adaptor protein; Provisional; Region: PRK02315 720555001914 Competence protein CoiA-like family; Region: CoiA; cl11541 720555001915 oligoendopeptidase F; Region: pepF; TIGR00181 720555001916 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 720555001917 active site 720555001918 Zn binding site [ion binding]; other site 720555001919 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 720555001920 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 720555001921 catalytic residues [active] 720555001922 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 720555001923 apolar tunnel; other site 720555001924 heme binding site [chemical binding]; other site 720555001925 dimerization interface [polypeptide binding]; other site 720555001926 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 720555001927 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 720555001928 N-acetyl-D-glucosamine binding site [chemical binding]; other site 720555001929 catalytic residue [active] 720555001930 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 720555001931 putative active site [active] 720555001932 putative metal binding residues [ion binding]; other site 720555001933 signature motif; other site 720555001934 putative triphosphate binding site [ion binding]; other site 720555001935 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 720555001936 synthetase active site [active] 720555001937 NTP binding site [chemical binding]; other site 720555001938 metal binding site [ion binding]; metal-binding site 720555001939 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 720555001940 ATP-NAD kinase; Region: NAD_kinase; pfam01513 720555001941 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 720555001942 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 720555001943 active site 720555001944 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 720555001945 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 720555001946 active site 720555001947 metal binding site [ion binding]; metal-binding site 720555001948 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 720555001949 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 720555001950 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 720555001951 TrkA-N domain; Region: TrkA_N; pfam02254 720555001952 TrkA-C domain; Region: TrkA_C; pfam02080 720555001953 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 720555001954 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 720555001955 thiamine phosphate binding site [chemical binding]; other site 720555001956 active site 720555001957 pyrophosphate binding site [ion binding]; other site 720555001958 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 720555001959 hydroxyglutarate oxidase; Provisional; Region: PRK11728 720555001960 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 720555001961 thiS-thiF/thiG interaction site; other site 720555001962 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 720555001963 ThiS interaction site; other site 720555001964 putative active site [active] 720555001965 tetramer interface [polypeptide binding]; other site 720555001966 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 720555001967 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 720555001968 ATP binding site [chemical binding]; other site 720555001969 substrate interface [chemical binding]; other site 720555001970 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 720555001971 dimer interface [polypeptide binding]; other site 720555001972 substrate binding site [chemical binding]; other site 720555001973 ATP binding site [chemical binding]; other site 720555001974 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 720555001975 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 720555001976 NAD binding site [chemical binding]; other site 720555001977 homotetramer interface [polypeptide binding]; other site 720555001978 homodimer interface [polypeptide binding]; other site 720555001979 substrate binding site [chemical binding]; other site 720555001980 active site 720555001981 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 720555001982 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 720555001983 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 720555001984 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 720555001985 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 720555001986 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 720555001987 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 720555001988 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 720555001989 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 720555001990 Part of AAA domain; Region: AAA_19; pfam13245 720555001991 Family description; Region: UvrD_C_2; pfam13538 720555001992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555001993 Coenzyme A binding pocket [chemical binding]; other site 720555001994 hypothetical protein; Provisional; Region: PRK13679 720555001995 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 720555001996 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 720555001997 Putative esterase; Region: Esterase; pfam00756 720555001998 cystathionine gamma-synthase; Reviewed; Region: PRK08247 720555001999 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 720555002000 homodimer interface [polypeptide binding]; other site 720555002001 substrate-cofactor binding pocket; other site 720555002002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555002003 catalytic residue [active] 720555002004 cystathionine beta-lyase; Provisional; Region: PRK08064 720555002005 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 720555002006 homodimer interface [polypeptide binding]; other site 720555002007 substrate-cofactor binding pocket; other site 720555002008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555002009 catalytic residue [active] 720555002010 Predicted integral membrane protein [Function unknown]; Region: COG5505 720555002011 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 720555002012 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 720555002013 Putative amidase domain; Region: Amidase_6; pfam12671 720555002014 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 720555002015 Right handed beta helix region; Region: Beta_helix; pfam13229 720555002016 Right handed beta helix region; Region: Beta_helix; pfam13229 720555002017 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD_2; pfam13653 720555002018 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 720555002019 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 720555002020 MgtC family; Region: MgtC; pfam02308 720555002021 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 720555002022 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 720555002023 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 720555002024 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 720555002025 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 720555002026 NodB motif; other site 720555002027 active site 720555002028 catalytic site [active] 720555002029 Zn binding site [ion binding]; other site 720555002030 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 720555002031 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 720555002032 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 720555002033 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 720555002034 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 720555002035 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 720555002036 4Fe-4S binding domain; Region: Fer4_6; pfam12837 720555002037 4Fe-4S binding domain; Region: Fer4; pfam00037 720555002038 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 720555002039 [4Fe-4S] binding site [ion binding]; other site 720555002040 molybdopterin cofactor binding site; other site 720555002041 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 720555002042 molybdopterin cofactor binding site; other site 720555002043 Uncharacterized conserved protein [Function unknown]; Region: COG2427 720555002044 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 720555002045 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 720555002046 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 720555002047 nudix motif; other site 720555002048 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 720555002049 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 720555002050 Cytochrome P450; Region: p450; cl12078 720555002051 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 720555002052 glycosyltransferase, MGT family; Region: MGT; TIGR01426 720555002053 active site 720555002054 TDP-binding site; other site 720555002055 acceptor substrate-binding pocket; other site 720555002056 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 720555002057 AAA domain; Region: AAA_18; pfam13238 720555002058 active site 720555002059 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 720555002060 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 720555002061 active site 720555002062 TIGR00245 family protein; Region: TIGR00245 720555002063 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 720555002064 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 720555002065 Walker A/P-loop; other site 720555002066 ATP binding site [chemical binding]; other site 720555002067 Q-loop/lid; other site 720555002068 ABC transporter signature motif; other site 720555002069 Walker B; other site 720555002070 D-loop; other site 720555002071 H-loop/switch region; other site 720555002072 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 720555002073 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 720555002074 Uncharacterized conserved protein [Function unknown]; Region: COG2427 720555002075 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 720555002076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555002077 Glucuronate isomerase; Region: UxaC; pfam02614 720555002078 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 720555002079 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 720555002080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555002081 putative substrate translocation pore; other site 720555002082 Transcriptional regulators [Transcription]; Region: PurR; COG1609 720555002083 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 720555002084 DNA binding site [nucleotide binding] 720555002085 domain linker motif; other site 720555002086 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 720555002087 dimerization interface [polypeptide binding]; other site 720555002088 ligand binding site [chemical binding]; other site 720555002089 altronate oxidoreductase; Provisional; Region: PRK03643 720555002090 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 720555002091 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 720555002092 galactarate dehydratase; Region: galactar-dH20; TIGR03248 720555002093 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 720555002094 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 720555002095 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 720555002096 DinB family; Region: DinB; pfam05163 720555002097 DinB superfamily; Region: DinB_2; pfam12867 720555002098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555002099 binding surface 720555002100 TPR motif; other site 720555002101 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555002102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555002103 binding surface 720555002104 TPR motif; other site 720555002105 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 720555002106 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 720555002107 amidase catalytic site [active] 720555002108 Zn binding residues [ion binding]; other site 720555002109 substrate binding site [chemical binding]; other site 720555002110 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555002111 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 720555002112 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 720555002113 pentamer interface [polypeptide binding]; other site 720555002114 dodecaamer interface [polypeptide binding]; other site 720555002115 Protein of unknown function (DUF867); Region: DUF867; pfam05908 720555002116 Domain of unknown function (DUF955); Region: DUF955; pfam06114 720555002117 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 720555002118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555002119 non-specific DNA binding site [nucleotide binding]; other site 720555002120 salt bridge; other site 720555002121 sequence-specific DNA binding site [nucleotide binding]; other site 720555002122 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555002123 putative Zn2+ binding site [ion binding]; other site 720555002124 putative DNA binding site [nucleotide binding]; other site 720555002125 hypothetical protein; Provisional; Region: PRK06921 720555002126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555002127 Walker A motif; other site 720555002128 ATP binding site [chemical binding]; other site 720555002129 Walker B motif; other site 720555002130 arginine finger; other site 720555002131 positive control sigma-like factor; Validated; Region: PRK06930 720555002132 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555002133 DNA binding residues [nucleotide binding] 720555002134 Phage terminase small subunit; Region: Phage_terminase; pfam10668 720555002135 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 720555002136 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 720555002137 Terminase-like family; Region: Terminase_6; pfam03237 720555002138 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 720555002139 Phage capsid family; Region: Phage_capsid; pfam05065 720555002140 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 720555002141 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 720555002142 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 720555002143 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 720555002144 Phage XkdN-like protein; Region: XkdN; pfam08890 720555002145 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 720555002146 N-acetyl-D-glucosamine binding site [chemical binding]; other site 720555002147 catalytic residue [active] 720555002148 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 720555002149 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555002150 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 720555002151 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 720555002152 dimer interface [polypeptide binding]; other site 720555002153 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555002154 metal binding site [ion binding]; metal-binding site 720555002155 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 720555002156 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 720555002157 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 720555002158 XkdW protein; Region: XkdW; pfam09636 720555002159 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 720555002160 Haemolysin XhlA; Region: XhlA; pfam10779 720555002161 Phage lysis protein, holin; Region: Phage_holin; pfam04688 720555002162 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 720555002163 amidase catalytic site [active] 720555002164 Zn binding residues [ion binding]; other site 720555002165 substrate binding site [chemical binding]; other site 720555002166 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555002167 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 720555002168 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 720555002169 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 720555002170 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 720555002171 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 720555002172 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 720555002173 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 720555002174 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 720555002175 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555002176 Zn binding site [ion binding]; other site 720555002177 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 720555002178 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555002179 Zn binding site [ion binding]; other site 720555002180 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 720555002181 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 720555002182 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 720555002183 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 720555002184 Ligand binding site; other site 720555002185 Putative Catalytic site; other site 720555002186 DXD motif; other site 720555002187 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 720555002188 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 720555002189 protein binding site [polypeptide binding]; other site 720555002190 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 720555002191 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 720555002192 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 720555002193 SxDxEG motif; other site 720555002194 active site 720555002195 metal binding site [ion binding]; metal-binding site 720555002196 homopentamer interface [polypeptide binding]; other site 720555002197 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 720555002198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555002199 dimer interface [polypeptide binding]; other site 720555002200 conserved gate region; other site 720555002201 putative PBP binding loops; other site 720555002202 ABC-ATPase subunit interface; other site 720555002203 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 720555002204 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 720555002205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555002206 putative PBP binding loops; other site 720555002207 dimer interface [polypeptide binding]; other site 720555002208 ABC-ATPase subunit interface; other site 720555002209 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 720555002210 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 720555002211 Walker A/P-loop; other site 720555002212 ATP binding site [chemical binding]; other site 720555002213 Q-loop/lid; other site 720555002214 ABC transporter signature motif; other site 720555002215 Walker B; other site 720555002216 D-loop; other site 720555002217 H-loop/switch region; other site 720555002218 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 720555002219 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 720555002220 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 720555002221 peptide binding site [polypeptide binding]; other site 720555002222 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 720555002223 dimer interface [polypeptide binding]; other site 720555002224 catalytic triad [active] 720555002225 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 720555002226 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 720555002227 active site 720555002228 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 720555002229 NlpC/P60 family; Region: NLPC_P60; pfam00877 720555002230 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 720555002231 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 720555002232 Walker A/P-loop; other site 720555002233 ATP binding site [chemical binding]; other site 720555002234 Q-loop/lid; other site 720555002235 ABC transporter signature motif; other site 720555002236 Walker B; other site 720555002237 D-loop; other site 720555002238 H-loop/switch region; other site 720555002239 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 720555002240 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 720555002241 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 720555002242 Amidinotransferase; Region: Amidinotransf; pfam02274 720555002243 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 720555002244 Predicted membrane protein [Function unknown]; Region: COG2323 720555002245 Predicted transcriptional regulators [Transcription]; Region: COG1695 720555002246 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 720555002247 hypothetical protein; Validated; Region: PRK07668 720555002248 Protein of unknown function, DUF393; Region: DUF393; pfam04134 720555002249 DinB superfamily; Region: DinB_2; pfam12867 720555002250 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 720555002251 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 720555002252 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 720555002253 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 720555002254 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 720555002255 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 720555002256 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 720555002257 putative active site [active] 720555002258 putative substrate binding site [chemical binding]; other site 720555002259 putative cosubstrate binding site; other site 720555002260 catalytic site [active] 720555002261 gamma-glutamyl kinase; Provisional; Region: PRK05429 720555002262 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 720555002263 nucleotide binding site [chemical binding]; other site 720555002264 homotetrameric interface [polypeptide binding]; other site 720555002265 putative phosphate binding site [ion binding]; other site 720555002266 putative allosteric binding site; other site 720555002267 PUA domain; Region: PUA; pfam01472 720555002268 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 720555002269 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 720555002270 putative catalytic cysteine [active] 720555002271 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 720555002272 Transcriptional regulators [Transcription]; Region: MarR; COG1846 720555002273 MarR family; Region: MarR; pfam01047 720555002274 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 720555002275 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 720555002276 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 720555002277 putative metal binding site; other site 720555002278 Tetratricopeptide repeat; Region: TPR_16; pfam13432 720555002279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555002280 binding surface 720555002281 TPR motif; other site 720555002282 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555002283 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 720555002284 nucleoside/Zn binding site; other site 720555002285 dimer interface [polypeptide binding]; other site 720555002286 catalytic motif [active] 720555002287 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 720555002288 catalytic core [active] 720555002289 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 720555002290 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 720555002291 THF binding site; other site 720555002292 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 720555002293 substrate binding site [chemical binding]; other site 720555002294 THF binding site; other site 720555002295 zinc-binding site [ion binding]; other site 720555002296 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 720555002297 active site 720555002298 catalytic residues [active] 720555002299 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 720555002300 Cobalt transport protein; Region: CbiQ; pfam02361 720555002301 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 720555002302 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 720555002303 Walker A/P-loop; other site 720555002304 ATP binding site [chemical binding]; other site 720555002305 Q-loop/lid; other site 720555002306 ABC transporter signature motif; other site 720555002307 Walker B; other site 720555002308 D-loop; other site 720555002309 H-loop/switch region; other site 720555002310 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 720555002311 Walker A/P-loop; other site 720555002312 ATP binding site [chemical binding]; other site 720555002313 Q-loop/lid; other site 720555002314 ABC transporter signature motif; other site 720555002315 Walker B; other site 720555002316 D-loop; other site 720555002317 H-loop/switch region; other site 720555002318 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 720555002319 YKOF-related Family; Region: Ykof; pfam07615 720555002320 YKOF-related Family; Region: Ykof; pfam07615 720555002321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555002322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555002323 active site 720555002324 phosphorylation site [posttranslational modification] 720555002325 intermolecular recognition site; other site 720555002326 dimerization interface [polypeptide binding]; other site 720555002327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 720555002328 DNA binding site [nucleotide binding] 720555002329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 720555002330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 720555002331 dimerization interface [polypeptide binding]; other site 720555002332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555002333 dimer interface [polypeptide binding]; other site 720555002334 phosphorylation site [posttranslational modification] 720555002335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555002336 ATP binding site [chemical binding]; other site 720555002337 Mg2+ binding site [ion binding]; other site 720555002338 G-X-G motif; other site 720555002339 Predicted membrane protein [Function unknown]; Region: COG3212 720555002340 Predicted membrane protein [Function unknown]; Region: COG3212 720555002341 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 720555002342 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 720555002343 Predicted membrane protein [Function unknown]; Region: COG3212 720555002344 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 720555002345 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 720555002346 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 720555002347 MgtE intracellular N domain; Region: MgtE_N; smart00924 720555002348 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 720555002349 Divalent cation transporter; Region: MgtE; pfam01769 720555002350 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 720555002351 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 720555002352 DNA binding residues [nucleotide binding] 720555002353 putative dimer interface [polypeptide binding]; other site 720555002354 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555002355 MarR family; Region: MarR; pfam01047 720555002356 MarR family; Region: MarR_2; cl17246 720555002357 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 720555002358 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 720555002359 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 720555002360 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 720555002361 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 720555002362 putative active site [active] 720555002363 putative metal binding site [ion binding]; other site 720555002364 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 720555002365 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 720555002366 Ligand binding site; other site 720555002367 Putative Catalytic site; other site 720555002368 DXD motif; other site 720555002369 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 720555002370 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 720555002371 active site 720555002372 DNA binding site [nucleotide binding] 720555002373 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 720555002374 nucleotide binding site [chemical binding]; other site 720555002375 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 720555002376 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 720555002377 putative DNA binding site [nucleotide binding]; other site 720555002378 putative homodimer interface [polypeptide binding]; other site 720555002379 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 720555002380 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 720555002381 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 720555002382 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 720555002383 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 720555002384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555002385 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 720555002386 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 720555002387 heat shock protein HtpX; Provisional; Region: PRK05457 720555002388 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 720555002389 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 720555002390 Predicted membrane protein [Function unknown]; Region: COG2323 720555002391 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 720555002392 Acyltransferase family; Region: Acyl_transf_3; pfam01757 720555002393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555002394 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 720555002395 putative active site [active] 720555002396 heme pocket [chemical binding]; other site 720555002397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555002398 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 720555002399 putative active site [active] 720555002400 heme pocket [chemical binding]; other site 720555002401 PAS domain; Region: PAS; smart00091 720555002402 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 720555002403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555002404 putative active site [active] 720555002405 heme pocket [chemical binding]; other site 720555002406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555002407 dimer interface [polypeptide binding]; other site 720555002408 phosphorylation site [posttranslational modification] 720555002409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555002410 ATP binding site [chemical binding]; other site 720555002411 Mg2+ binding site [ion binding]; other site 720555002412 G-X-G motif; other site 720555002413 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 720555002414 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 720555002415 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 720555002416 DNA binding site [nucleotide binding] 720555002417 active site 720555002418 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 720555002419 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 720555002420 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 720555002421 Phosphotransferase enzyme family; Region: APH; pfam01636 720555002422 Predicted amidohydrolase [General function prediction only]; Region: COG0388 720555002423 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 720555002424 putative active site [active] 720555002425 catalytic triad [active] 720555002426 putative dimer interface [polypeptide binding]; other site 720555002427 transaminase; Reviewed; Region: PRK08068 720555002428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555002429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555002430 homodimer interface [polypeptide binding]; other site 720555002431 catalytic residue [active] 720555002432 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 720555002433 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 720555002434 dimer interface [polypeptide binding]; other site 720555002435 active site 720555002436 catalytic residue [active] 720555002437 metal binding site [ion binding]; metal-binding site 720555002438 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 720555002439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555002440 motif II; other site 720555002441 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 720555002442 intersubunit interface [polypeptide binding]; other site 720555002443 active site 720555002444 Zn2+ binding site [ion binding]; other site 720555002445 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 720555002446 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 720555002447 Cupin domain; Region: Cupin_2; pfam07883 720555002448 Uncharacterized conserved protein [Function unknown]; Region: COG3339 720555002449 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 720555002450 Cache domain; Region: Cache_1; pfam02743 720555002451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555002452 dimer interface [polypeptide binding]; other site 720555002453 phosphorylation site [posttranslational modification] 720555002454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555002455 ATP binding site [chemical binding]; other site 720555002456 Mg2+ binding site [ion binding]; other site 720555002457 G-X-G motif; other site 720555002458 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555002459 MarR family; Region: MarR; pfam01047 720555002460 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 720555002461 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 720555002462 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 720555002463 ligand binding site [chemical binding]; other site 720555002464 flagellar motor protein MotA; Validated; Region: PRK08124 720555002465 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 720555002466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555002467 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 720555002468 Walker A motif; other site 720555002469 ATP binding site [chemical binding]; other site 720555002470 Walker B motif; other site 720555002471 arginine finger; other site 720555002472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555002473 Walker A motif; other site 720555002474 ATP binding site [chemical binding]; other site 720555002475 Walker B motif; other site 720555002476 arginine finger; other site 720555002477 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 720555002478 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 720555002479 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 720555002480 Ligand Binding Site [chemical binding]; other site 720555002481 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 720555002482 active site 720555002483 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 720555002484 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 720555002485 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 720555002486 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 720555002487 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 720555002488 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 720555002489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555002490 Coenzyme A binding pocket [chemical binding]; other site 720555002491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 720555002492 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 720555002493 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 720555002494 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 720555002495 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 720555002496 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 720555002497 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 720555002498 catalytic residues [active] 720555002499 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 720555002500 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 720555002501 Soluble P-type ATPase [General function prediction only]; Region: COG4087 720555002502 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 720555002503 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 720555002504 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 720555002505 active site 720555002506 Transcriptional regulators [Transcription]; Region: PurR; COG1609 720555002507 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 720555002508 DNA binding site [nucleotide binding] 720555002509 domain linker motif; other site 720555002510 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 720555002511 putative dimerization interface [polypeptide binding]; other site 720555002512 putative ligand binding site [chemical binding]; other site 720555002513 CAT RNA binding domain; Region: CAT_RBD; pfam03123 720555002514 transcriptional antiterminator BglG; Provisional; Region: PRK09772 720555002515 PRD domain; Region: PRD; pfam00874 720555002516 PRD domain; Region: PRD; pfam00874 720555002517 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 720555002518 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 720555002519 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 720555002520 active site turn [active] 720555002521 phosphorylation site [posttranslational modification] 720555002522 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 720555002523 HPr interaction site; other site 720555002524 glycerol kinase (GK) interaction site [polypeptide binding]; other site 720555002525 active site 720555002526 phosphorylation site [posttranslational modification] 720555002527 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 720555002528 dimerization domain swap beta strand [polypeptide binding]; other site 720555002529 regulatory protein interface [polypeptide binding]; other site 720555002530 active site 720555002531 regulatory phosphorylation site [posttranslational modification]; other site 720555002532 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 720555002533 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 720555002534 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 720555002535 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 720555002536 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 720555002537 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 720555002538 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 720555002539 FeS/SAM binding site; other site 720555002540 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 720555002541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555002542 Coenzyme A binding pocket [chemical binding]; other site 720555002543 Cache domain; Region: Cache_1; pfam02743 720555002544 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 720555002545 dimerization interface [polypeptide binding]; other site 720555002546 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 720555002547 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 720555002548 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 720555002549 dimer interface [polypeptide binding]; other site 720555002550 putative CheW interface [polypeptide binding]; other site 720555002551 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 720555002552 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 720555002553 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 720555002554 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 720555002555 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 720555002556 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 720555002557 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 720555002558 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 720555002559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555002560 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 720555002561 putative active site [active] 720555002562 heme pocket [chemical binding]; other site 720555002563 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555002564 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 720555002565 putative active site [active] 720555002566 heme pocket [chemical binding]; other site 720555002567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555002568 putative active site [active] 720555002569 heme pocket [chemical binding]; other site 720555002570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555002571 dimer interface [polypeptide binding]; other site 720555002572 phosphorylation site [posttranslational modification] 720555002573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555002574 ATP binding site [chemical binding]; other site 720555002575 Mg2+ binding site [ion binding]; other site 720555002576 G-X-G motif; other site 720555002577 aminotransferase A; Validated; Region: PRK07683 720555002578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555002579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555002580 homodimer interface [polypeptide binding]; other site 720555002581 catalytic residue [active] 720555002582 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 720555002583 putative CheA interaction surface; other site 720555002584 Response regulator receiver domain; Region: Response_reg; pfam00072 720555002585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555002586 active site 720555002587 phosphorylation site [posttranslational modification] 720555002588 intermolecular recognition site; other site 720555002589 dimerization interface [polypeptide binding]; other site 720555002590 YkyB-like protein; Region: YkyB; pfam14177 720555002591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555002592 H+ Antiporter protein; Region: 2A0121; TIGR00900 720555002593 putative substrate translocation pore; other site 720555002594 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555002595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 720555002596 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 720555002597 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 720555002598 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 720555002599 putative active site [active] 720555002600 putative metal binding site [ion binding]; other site 720555002601 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 720555002602 short chain dehydrogenase; Provisional; Region: PRK07677 720555002603 NAD(P) binding site [chemical binding]; other site 720555002604 substrate binding site [chemical binding]; other site 720555002605 homotetramer interface [polypeptide binding]; other site 720555002606 active site 720555002607 homodimer interface [polypeptide binding]; other site 720555002608 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 720555002609 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 720555002610 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 720555002611 dinuclear metal binding motif [ion binding]; other site 720555002612 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 720555002613 Protein of unknown function (DUF458); Region: DUF458; pfam04308 720555002614 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 720555002615 FOG: CBS domain [General function prediction only]; Region: COG0517 720555002616 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 720555002617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555002618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555002619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 720555002620 dimerization interface [polypeptide binding]; other site 720555002621 flavodoxin; Provisional; Region: PRK06703 720555002622 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 720555002623 flavodoxin, short chain; Region: flav_short; TIGR01753 720555002624 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 720555002625 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 720555002626 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 720555002627 active site 720555002628 trimer interface [polypeptide binding]; other site 720555002629 substrate binding site [chemical binding]; other site 720555002630 CoA binding site [chemical binding]; other site 720555002631 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 720555002632 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 720555002633 metal binding site [ion binding]; metal-binding site 720555002634 putative dimer interface [polypeptide binding]; other site 720555002635 hypothetical protein; Provisional; Region: PRK03094 720555002636 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 720555002637 Mechanosensitive ion channel; Region: MS_channel; pfam00924 720555002638 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 720555002639 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 720555002640 dimer interface [polypeptide binding]; other site 720555002641 decamer (pentamer of dimers) interface [polypeptide binding]; other site 720555002642 catalytic triad [active] 720555002643 peroxidatic and resolving cysteines [active] 720555002644 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 720555002645 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 720555002646 catalytic residues [active] 720555002647 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 720555002648 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 720555002649 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 720555002650 GTP binding site; other site 720555002651 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 720555002652 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 720555002653 ATP binding site [chemical binding]; other site 720555002654 substrate interface [chemical binding]; other site 720555002655 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 720555002656 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 720555002657 dimer interface [polypeptide binding]; other site 720555002658 putative functional site; other site 720555002659 putative MPT binding site; other site 720555002660 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 720555002661 Walker A motif; other site 720555002662 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 720555002663 MoaE homodimer interface [polypeptide binding]; other site 720555002664 MoaD interaction [polypeptide binding]; other site 720555002665 active site residues [active] 720555002666 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 720555002667 MoaE interaction surface [polypeptide binding]; other site 720555002668 MoeB interaction surface [polypeptide binding]; other site 720555002669 thiocarboxylated glycine; other site 720555002670 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 720555002671 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 720555002672 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 720555002673 Walker A/P-loop; other site 720555002674 ATP binding site [chemical binding]; other site 720555002675 Q-loop/lid; other site 720555002676 ABC transporter signature motif; other site 720555002677 Walker B; other site 720555002678 D-loop; other site 720555002679 H-loop/switch region; other site 720555002680 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 720555002681 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 720555002682 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 720555002683 Walker A/P-loop; other site 720555002684 ATP binding site [chemical binding]; other site 720555002685 Q-loop/lid; other site 720555002686 ABC transporter signature motif; other site 720555002687 Walker B; other site 720555002688 D-loop; other site 720555002689 H-loop/switch region; other site 720555002690 Yip1 domain; Region: Yip1; pfam04893 720555002691 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 720555002692 HlyD family secretion protein; Region: HlyD_3; pfam13437 720555002693 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 720555002694 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 720555002695 Walker A/P-loop; other site 720555002696 ATP binding site [chemical binding]; other site 720555002697 Q-loop/lid; other site 720555002698 ABC transporter signature motif; other site 720555002699 Walker B; other site 720555002700 D-loop; other site 720555002701 H-loop/switch region; other site 720555002702 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 720555002703 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 720555002704 FtsX-like permease family; Region: FtsX; pfam02687 720555002705 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 720555002706 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 720555002707 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 720555002708 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 720555002709 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 720555002710 putative substrate binding site [chemical binding]; other site 720555002711 putative ATP binding site [chemical binding]; other site 720555002712 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 720555002713 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 720555002714 active site 720555002715 phosphorylation site [posttranslational modification] 720555002716 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 720555002717 active site 720555002718 P-loop; other site 720555002719 phosphorylation site [posttranslational modification] 720555002720 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 720555002721 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 720555002722 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 720555002723 Catalytic site [active] 720555002724 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 720555002725 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555002726 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555002727 ABC transporter; Region: ABC_tran_2; pfam12848 720555002728 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555002729 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 720555002730 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 720555002731 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 720555002732 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 720555002733 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 720555002734 rod-share determining protein MreBH; Provisional; Region: PRK13929 720555002735 MreB and similar proteins; Region: MreB_like; cd10225 720555002736 nucleotide binding site [chemical binding]; other site 720555002737 Mg binding site [ion binding]; other site 720555002738 putative protofilament interaction site [polypeptide binding]; other site 720555002739 RodZ interaction site [polypeptide binding]; other site 720555002740 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 720555002741 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 720555002742 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 720555002743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555002744 putative active site [active] 720555002745 heme pocket [chemical binding]; other site 720555002746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555002747 dimer interface [polypeptide binding]; other site 720555002748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555002749 ATP binding site [chemical binding]; other site 720555002750 Mg2+ binding site [ion binding]; other site 720555002751 G-X-G motif; other site 720555002752 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 720555002753 putative active site pocket [active] 720555002754 dimerization interface [polypeptide binding]; other site 720555002755 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 720555002756 putative active site pocket [active] 720555002757 dimerization interface [polypeptide binding]; other site 720555002758 putative catalytic residue [active] 720555002759 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 720555002760 TrkA-N domain; Region: TrkA_N; pfam02254 720555002761 TrkA-C domain; Region: TrkA_C; pfam02080 720555002762 adenine deaminase; Region: ade; TIGR01178 720555002763 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 720555002764 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 720555002765 active site 720555002766 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 720555002767 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 720555002768 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 720555002769 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 720555002770 hypothetical protein; Provisional; Region: PRK13667 720555002771 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 720555002772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555002773 active site 720555002774 motif I; other site 720555002775 motif II; other site 720555002776 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 720555002777 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 720555002778 active site 720555002779 catalytic residues [active] 720555002780 metal binding site [ion binding]; metal-binding site 720555002781 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 720555002782 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 720555002783 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 720555002784 TPP-binding site [chemical binding]; other site 720555002785 tetramer interface [polypeptide binding]; other site 720555002786 heterodimer interface [polypeptide binding]; other site 720555002787 phosphorylation loop region [posttranslational modification] 720555002788 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 720555002789 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 720555002790 alpha subunit interface [polypeptide binding]; other site 720555002791 TPP binding site [chemical binding]; other site 720555002792 heterodimer interface [polypeptide binding]; other site 720555002793 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 720555002794 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 720555002795 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 720555002796 E3 interaction surface; other site 720555002797 lipoyl attachment site [posttranslational modification]; other site 720555002798 e3 binding domain; Region: E3_binding; pfam02817 720555002799 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 720555002800 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 720555002801 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 720555002802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555002803 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 720555002804 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 720555002805 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 720555002806 NodB motif; other site 720555002807 active site 720555002808 catalytic site [active] 720555002809 metal binding site [ion binding]; metal-binding site 720555002810 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 720555002811 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 720555002812 homodimer interface [polypeptide binding]; other site 720555002813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555002814 catalytic residue [active] 720555002815 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 720555002816 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 720555002817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 720555002818 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 720555002819 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 720555002820 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 720555002821 active site 720555002822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 720555002823 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 720555002824 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 720555002825 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 720555002826 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 720555002827 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 720555002828 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 720555002829 active site 720555002830 Zn binding site [ion binding]; other site 720555002831 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555002832 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 720555002833 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555002834 DNA binding residues [nucleotide binding] 720555002835 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 720555002836 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 720555002837 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 720555002838 G1 box; other site 720555002839 putative GEF interaction site [polypeptide binding]; other site 720555002840 GTP/Mg2+ binding site [chemical binding]; other site 720555002841 Switch I region; other site 720555002842 G2 box; other site 720555002843 G3 box; other site 720555002844 Switch II region; other site 720555002845 G4 box; other site 720555002846 G5 box; other site 720555002847 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 720555002848 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 720555002849 YlaH-like protein; Region: YlaH; pfam14036 720555002850 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 720555002851 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 720555002852 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 720555002853 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 720555002854 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 720555002855 putative active site [active] 720555002856 PhoH-like protein; Region: PhoH; pfam02562 720555002857 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 720555002858 glutaminase A; Region: Gln_ase; TIGR03814 720555002859 hypothetical protein; Provisional; Region: PRK13666 720555002860 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 720555002861 pyruvate carboxylase; Reviewed; Region: PRK12999 720555002862 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 720555002863 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 720555002864 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 720555002865 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 720555002866 active site 720555002867 catalytic residues [active] 720555002868 metal binding site [ion binding]; metal-binding site 720555002869 homodimer binding site [polypeptide binding]; other site 720555002870 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 720555002871 carboxyltransferase (CT) interaction site; other site 720555002872 biotinylation site [posttranslational modification]; other site 720555002873 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 720555002874 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 720555002875 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 720555002876 UbiA prenyltransferase family; Region: UbiA; pfam01040 720555002877 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 720555002878 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 720555002879 Cytochrome c; Region: Cytochrom_C; pfam00034 720555002880 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 720555002881 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 720555002882 D-pathway; other site 720555002883 Putative ubiquinol binding site [chemical binding]; other site 720555002884 Low-spin heme (heme b) binding site [chemical binding]; other site 720555002885 Putative water exit pathway; other site 720555002886 Binuclear center (heme o3/CuB) [ion binding]; other site 720555002887 K-pathway; other site 720555002888 Putative proton exit pathway; other site 720555002889 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 720555002890 Subunit I/III interface [polypeptide binding]; other site 720555002891 Subunit III/IV interface [polypeptide binding]; other site 720555002892 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 720555002893 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 720555002894 YugN-like family; Region: YugN; pfam08868 720555002895 FOG: CBS domain [General function prediction only]; Region: COG0517 720555002896 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 720555002897 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 720555002898 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 720555002899 Putative coat protein; Region: YlbD_coat; pfam14071 720555002900 YlbE-like protein; Region: YlbE; pfam14003 720555002901 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 720555002902 hypothetical protein; Provisional; Region: PRK02886 720555002903 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 720555002904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555002905 S-adenosylmethionine binding site [chemical binding]; other site 720555002906 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 720555002907 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 720555002908 active site 720555002909 (T/H)XGH motif; other site 720555002910 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 720555002911 Nucleoside recognition; Region: Gate; pfam07670 720555002912 Nucleoside recognition; Region: Gate; pfam07670 720555002913 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 720555002914 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 720555002915 nucleophile elbow; other site 720555002916 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 720555002917 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 720555002918 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 720555002919 protein binding site [polypeptide binding]; other site 720555002920 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 720555002921 hypothetical protein; Provisional; Region: PRK13670 720555002922 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 720555002923 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 720555002924 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 720555002925 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 720555002926 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 720555002927 hypothetical protein; Provisional; Region: PRK13688 720555002928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555002929 Coenzyme A binding pocket [chemical binding]; other site 720555002930 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 720555002931 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 720555002932 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 720555002933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 720555002934 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 720555002935 mraZ protein; Region: TIGR00242 720555002936 MraZ protein; Region: MraZ; pfam02381 720555002937 MraZ protein; Region: MraZ; pfam02381 720555002938 MraW methylase family; Region: Methyltransf_5; pfam01795 720555002939 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 720555002940 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 720555002941 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 720555002942 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 720555002943 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 720555002944 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 720555002945 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 720555002946 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 720555002947 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 720555002948 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 720555002949 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 720555002950 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 720555002951 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 720555002952 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 720555002953 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 720555002954 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 720555002955 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 720555002956 Mg++ binding site [ion binding]; other site 720555002957 putative catalytic motif [active] 720555002958 putative substrate binding site [chemical binding]; other site 720555002959 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 720555002960 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 720555002961 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 720555002962 stage V sporulation protein E; Region: spoVE; TIGR02615 720555002963 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 720555002964 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 720555002965 active site 720555002966 homodimer interface [polypeptide binding]; other site 720555002967 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 720555002968 FAD binding domain; Region: FAD_binding_4; pfam01565 720555002969 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 720555002970 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 720555002971 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 720555002972 Cell division protein FtsQ; Region: FtsQ; pfam03799 720555002973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 720555002974 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 720555002975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 720555002976 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 720555002977 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 720555002978 cell division protein FtsA; Region: ftsA; TIGR01174 720555002979 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 720555002980 nucleotide binding site [chemical binding]; other site 720555002981 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 720555002982 Cell division protein FtsA; Region: FtsA; pfam14450 720555002983 cell division protein FtsZ; Validated; Region: PRK09330 720555002984 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 720555002985 nucleotide binding site [chemical binding]; other site 720555002986 SulA interaction site; other site 720555002987 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 720555002988 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 720555002989 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 720555002990 active site 720555002991 catalytic triad [active] 720555002992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 720555002993 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 720555002994 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 720555002995 Cna protein B-type domain; Region: Cna_B_2; pfam13715 720555002996 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 720555002997 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 720555002998 sporulation sigma factor SigE; Reviewed; Region: PRK08301 720555002999 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555003000 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555003001 DNA binding residues [nucleotide binding] 720555003002 sporulation sigma factor SigG; Reviewed; Region: PRK08215 720555003003 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555003004 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 720555003005 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555003006 DNA binding residues [nucleotide binding] 720555003007 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 720555003008 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 720555003009 Walker A/P-loop; other site 720555003010 ATP binding site [chemical binding]; other site 720555003011 Q-loop/lid; other site 720555003012 ABC transporter signature motif; other site 720555003013 Walker B; other site 720555003014 D-loop; other site 720555003015 H-loop/switch region; other site 720555003016 acetylornithine deacetylase; Validated; Region: PRK08596 720555003017 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 720555003018 metal binding site [ion binding]; metal-binding site 720555003019 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 720555003020 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 720555003021 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 720555003022 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 720555003023 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 720555003024 catalytic residue [active] 720555003025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 720555003026 YGGT family; Region: YGGT; pfam02325 720555003027 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 720555003028 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 720555003029 RNA binding surface [nucleotide binding]; other site 720555003030 DivIVA protein; Region: DivIVA; pfam05103 720555003031 DivIVA domain; Region: DivI1A_domain; TIGR03544 720555003032 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 720555003033 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 720555003034 HIGH motif; other site 720555003035 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 720555003036 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 720555003037 active site 720555003038 KMSKS motif; other site 720555003039 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 720555003040 tRNA binding surface [nucleotide binding]; other site 720555003041 anticodon binding site; other site 720555003042 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 720555003043 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 720555003044 lipoprotein signal peptidase; Provisional; Region: PRK14787 720555003045 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 720555003046 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 720555003047 RNA binding surface [nucleotide binding]; other site 720555003048 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 720555003049 active site 720555003050 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 720555003051 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 720555003052 active site 720555003053 uracil-xanthine permease; Region: ncs2; TIGR00801 720555003054 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 720555003055 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 720555003056 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 720555003057 dihydroorotase; Validated; Region: pyrC; PRK09357 720555003058 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 720555003059 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 720555003060 active site 720555003061 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 720555003062 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 720555003063 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 720555003064 catalytic site [active] 720555003065 subunit interface [polypeptide binding]; other site 720555003066 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 720555003067 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 720555003068 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 720555003069 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 720555003070 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 720555003071 ATP-grasp domain; Region: ATP-grasp_4; cl17255 720555003072 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 720555003073 IMP binding site; other site 720555003074 dimer interface [polypeptide binding]; other site 720555003075 interdomain contacts; other site 720555003076 partial ornithine binding site; other site 720555003077 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 720555003078 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 720555003079 FAD binding pocket [chemical binding]; other site 720555003080 FAD binding motif [chemical binding]; other site 720555003081 phosphate binding motif [ion binding]; other site 720555003082 beta-alpha-beta structure motif; other site 720555003083 NAD binding pocket [chemical binding]; other site 720555003084 Iron coordination center [ion binding]; other site 720555003085 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 720555003086 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 720555003087 heterodimer interface [polypeptide binding]; other site 720555003088 active site 720555003089 FMN binding site [chemical binding]; other site 720555003090 homodimer interface [polypeptide binding]; other site 720555003091 substrate binding site [chemical binding]; other site 720555003092 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 720555003093 active site 720555003094 dimer interface [polypeptide binding]; other site 720555003095 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 720555003096 active site 720555003097 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 720555003098 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 720555003099 Active Sites [active] 720555003100 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 720555003101 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 720555003102 ATP-sulfurylase; Region: ATPS; cd00517 720555003103 active site 720555003104 HXXH motif; other site 720555003105 flexible loop; other site 720555003106 AAA domain; Region: AAA_33; pfam13671 720555003107 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 720555003108 ligand-binding site [chemical binding]; other site 720555003109 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 720555003110 diphthine synthase; Region: dph5; TIGR00522 720555003111 active site 720555003112 SAM binding site [chemical binding]; other site 720555003113 homodimer interface [polypeptide binding]; other site 720555003114 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 720555003115 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 720555003116 putative active site [active] 720555003117 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 720555003118 putative active site [active] 720555003119 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 720555003120 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 720555003121 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 720555003122 Domain of unknown function (DUF814); Region: DUF814; pfam05670 720555003123 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 720555003124 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 720555003125 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 720555003126 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 720555003127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555003128 motif II; other site 720555003129 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 720555003130 hypothetical protein; Provisional; Region: PRK11820 720555003131 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 720555003132 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 720555003133 hypothetical protein; Provisional; Region: PRK04323 720555003134 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 720555003135 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 720555003136 catalytic site [active] 720555003137 G-X2-G-X-G-K; other site 720555003138 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 720555003139 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 720555003140 Flavoprotein; Region: Flavoprotein; pfam02441 720555003141 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 720555003142 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 720555003143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 720555003144 ATP binding site [chemical binding]; other site 720555003145 putative Mg++ binding site [ion binding]; other site 720555003146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555003147 nucleotide binding region [chemical binding]; other site 720555003148 ATP-binding site [chemical binding]; other site 720555003149 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 720555003150 active site 720555003151 catalytic residues [active] 720555003152 metal binding site [ion binding]; metal-binding site 720555003153 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 720555003154 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 720555003155 putative active site [active] 720555003156 substrate binding site [chemical binding]; other site 720555003157 putative cosubstrate binding site; other site 720555003158 catalytic site [active] 720555003159 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 720555003160 substrate binding site [chemical binding]; other site 720555003161 16S rRNA methyltransferase B; Provisional; Region: PRK14902 720555003162 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 720555003163 putative RNA binding site [nucleotide binding]; other site 720555003164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555003165 S-adenosylmethionine binding site [chemical binding]; other site 720555003166 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 720555003167 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 720555003168 FeS/SAM binding site; other site 720555003169 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 720555003170 Protein phosphatase 2C; Region: PP2C; pfam00481 720555003171 active site 720555003172 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 720555003173 Catalytic domain of Protein Kinases; Region: PKc; cd00180 720555003174 active site 720555003175 ATP binding site [chemical binding]; other site 720555003176 substrate binding site [chemical binding]; other site 720555003177 activation loop (A-loop); other site 720555003178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 720555003179 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 720555003180 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 720555003181 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 720555003182 GTPase RsgA; Reviewed; Region: PRK00098 720555003183 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 720555003184 RNA binding site [nucleotide binding]; other site 720555003185 homodimer interface [polypeptide binding]; other site 720555003186 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 720555003187 GTPase/Zn-binding domain interface [polypeptide binding]; other site 720555003188 GTP/Mg2+ binding site [chemical binding]; other site 720555003189 G4 box; other site 720555003190 G5 box; other site 720555003191 G1 box; other site 720555003192 Switch I region; other site 720555003193 G2 box; other site 720555003194 G3 box; other site 720555003195 Switch II region; other site 720555003196 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 720555003197 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 720555003198 substrate binding site [chemical binding]; other site 720555003199 hexamer interface [polypeptide binding]; other site 720555003200 metal binding site [ion binding]; metal-binding site 720555003201 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 720555003202 Thiamine pyrophosphokinase; Region: TPK; cd07995 720555003203 active site 720555003204 dimerization interface [polypeptide binding]; other site 720555003205 thiamine binding site [chemical binding]; other site 720555003206 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 720555003207 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 720555003208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 720555003209 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 720555003210 DAK2 domain; Region: Dak2; pfam02734 720555003211 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 720555003212 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 720555003213 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 720555003214 putative L-serine binding site [chemical binding]; other site 720555003215 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 720555003216 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 720555003217 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 720555003218 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 720555003219 generic binding surface II; other site 720555003220 ssDNA binding site; other site 720555003221 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 720555003222 ATP binding site [chemical binding]; other site 720555003223 putative Mg++ binding site [ion binding]; other site 720555003224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555003225 nucleotide binding region [chemical binding]; other site 720555003226 ATP-binding site [chemical binding]; other site 720555003227 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 720555003228 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 720555003229 putative phosphate acyltransferase; Provisional; Region: PRK05331 720555003230 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 720555003231 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 720555003232 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 720555003233 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 720555003234 NAD(P) binding site [chemical binding]; other site 720555003235 homotetramer interface [polypeptide binding]; other site 720555003236 homodimer interface [polypeptide binding]; other site 720555003237 active site 720555003238 acyl carrier protein; Provisional; Region: acpP; PRK00982 720555003239 ribonuclease III; Reviewed; Region: rnc; PRK00102 720555003240 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 720555003241 dimerization interface [polypeptide binding]; other site 720555003242 active site 720555003243 metal binding site [ion binding]; metal-binding site 720555003244 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 720555003245 dsRNA binding site [nucleotide binding]; other site 720555003246 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 720555003247 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 720555003248 Walker A/P-loop; other site 720555003249 ATP binding site [chemical binding]; other site 720555003250 Q-loop/lid; other site 720555003251 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 720555003252 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 720555003253 ABC transporter signature motif; other site 720555003254 Walker B; other site 720555003255 D-loop; other site 720555003256 H-loop/switch region; other site 720555003257 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 720555003258 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 720555003259 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 720555003260 GTP binding site [chemical binding]; other site 720555003261 putative DNA-binding protein; Validated; Region: PRK00118 720555003262 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 720555003263 signal recognition particle protein; Provisional; Region: PRK10867 720555003264 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 720555003265 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 720555003266 P loop; other site 720555003267 GTP binding site [chemical binding]; other site 720555003268 Signal peptide binding domain; Region: SRP_SPB; pfam02978 720555003269 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 720555003270 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 720555003271 KH domain; Region: KH_4; pfam13083 720555003272 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 720555003273 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 720555003274 RimM N-terminal domain; Region: RimM; pfam01782 720555003275 PRC-barrel domain; Region: PRC; pfam05239 720555003276 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 720555003277 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 720555003278 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 720555003279 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 720555003280 GTP/Mg2+ binding site [chemical binding]; other site 720555003281 G4 box; other site 720555003282 G5 box; other site 720555003283 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 720555003284 G1 box; other site 720555003285 G1 box; other site 720555003286 GTP/Mg2+ binding site [chemical binding]; other site 720555003287 Switch I region; other site 720555003288 G2 box; other site 720555003289 G2 box; other site 720555003290 G3 box; other site 720555003291 G3 box; other site 720555003292 Switch II region; other site 720555003293 Switch II region; other site 720555003294 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 720555003295 RNA/DNA hybrid binding site [nucleotide binding]; other site 720555003296 active site 720555003297 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 720555003298 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 720555003299 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 720555003300 CoA-ligase; Region: Ligase_CoA; pfam00549 720555003301 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 720555003302 CoA binding domain; Region: CoA_binding; smart00881 720555003303 CoA-ligase; Region: Ligase_CoA; pfam00549 720555003304 DNA protecting protein DprA; Region: dprA; TIGR00732 720555003305 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 720555003306 DNA topoisomerase I; Validated; Region: PRK05582 720555003307 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 720555003308 active site 720555003309 interdomain interaction site; other site 720555003310 putative metal-binding site [ion binding]; other site 720555003311 nucleotide binding site [chemical binding]; other site 720555003312 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 720555003313 domain I; other site 720555003314 DNA binding groove [nucleotide binding] 720555003315 phosphate binding site [ion binding]; other site 720555003316 domain II; other site 720555003317 domain III; other site 720555003318 nucleotide binding site [chemical binding]; other site 720555003319 catalytic site [active] 720555003320 domain IV; other site 720555003321 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 720555003322 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 720555003323 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 720555003324 Glucose inhibited division protein A; Region: GIDA; pfam01134 720555003325 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 720555003326 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 720555003327 active site 720555003328 Int/Topo IB signature motif; other site 720555003329 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 720555003330 active site 720555003331 HslU subunit interaction site [polypeptide binding]; other site 720555003332 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 720555003333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555003334 Walker A motif; other site 720555003335 ATP binding site [chemical binding]; other site 720555003336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555003337 Walker B motif; other site 720555003338 arginine finger; other site 720555003339 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 720555003340 transcriptional repressor CodY; Validated; Region: PRK04158 720555003341 CodY GAF-like domain; Region: CodY; pfam06018 720555003342 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 720555003343 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 720555003344 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 720555003345 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 720555003346 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 720555003347 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 720555003348 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 720555003349 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 720555003350 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 720555003351 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 720555003352 flagellar motor switch protein FliG; Region: fliG; TIGR00207 720555003353 MgtE intracellular N domain; Region: MgtE_N; smart00924 720555003354 FliG C-terminal domain; Region: FliG_C; pfam01706 720555003355 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 720555003356 Flagellar assembly protein FliH; Region: FliH; pfam02108 720555003357 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 720555003358 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 720555003359 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 720555003360 Walker A motif/ATP binding site; other site 720555003361 Walker B motif; other site 720555003362 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 720555003363 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 720555003364 Uncharacterized conserved protein [Function unknown]; Region: COG3334 720555003365 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 720555003366 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 720555003367 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 720555003368 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 720555003369 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 720555003370 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 720555003371 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 720555003372 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 720555003373 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 720555003374 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 720555003375 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 720555003376 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 720555003377 flagellar motor switch protein; Validated; Region: PRK08119 720555003378 CheC-like family; Region: CheC; pfam04509 720555003379 CheC-like family; Region: CheC; pfam04509 720555003380 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 720555003381 Response regulator receiver domain; Region: Response_reg; pfam00072 720555003382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555003383 active site 720555003384 phosphorylation site [posttranslational modification] 720555003385 intermolecular recognition site; other site 720555003386 dimerization interface [polypeptide binding]; other site 720555003387 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 720555003388 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 720555003389 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 720555003390 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 720555003391 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 720555003392 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 720555003393 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 720555003394 FHIPEP family; Region: FHIPEP; pfam00771 720555003395 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 720555003396 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 720555003397 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 720555003398 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 720555003399 P-loop; other site 720555003400 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 720555003401 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 720555003402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555003403 active site 720555003404 phosphorylation site [posttranslational modification] 720555003405 intermolecular recognition site; other site 720555003406 dimerization interface [polypeptide binding]; other site 720555003407 CheB methylesterase; Region: CheB_methylest; pfam01339 720555003408 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 720555003409 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 720555003410 putative binding surface; other site 720555003411 active site 720555003412 P2 response regulator binding domain; Region: P2; pfam07194 720555003413 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 720555003414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555003415 ATP binding site [chemical binding]; other site 720555003416 Mg2+ binding site [ion binding]; other site 720555003417 G-X-G motif; other site 720555003418 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 720555003419 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 720555003420 putative CheA interaction surface; other site 720555003421 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 720555003422 CheC-like family; Region: CheC; pfam04509 720555003423 CheC-like family; Region: CheC; pfam04509 720555003424 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 720555003425 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 720555003426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555003427 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 720555003428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555003429 DNA binding residues [nucleotide binding] 720555003430 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 720555003431 rRNA interaction site [nucleotide binding]; other site 720555003432 S8 interaction site; other site 720555003433 putative laminin-1 binding site; other site 720555003434 elongation factor Ts; Provisional; Region: tsf; PRK09377 720555003435 UBA/TS-N domain; Region: UBA; pfam00627 720555003436 Elongation factor TS; Region: EF_TS; pfam00889 720555003437 Elongation factor TS; Region: EF_TS; pfam00889 720555003438 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 720555003439 putative nucleotide binding site [chemical binding]; other site 720555003440 uridine monophosphate binding site [chemical binding]; other site 720555003441 homohexameric interface [polypeptide binding]; other site 720555003442 ribosome recycling factor; Reviewed; Region: frr; PRK00083 720555003443 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 720555003444 hinge region; other site 720555003445 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 720555003446 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 720555003447 catalytic residue [active] 720555003448 putative FPP diphosphate binding site; other site 720555003449 putative FPP binding hydrophobic cleft; other site 720555003450 dimer interface [polypeptide binding]; other site 720555003451 putative IPP diphosphate binding site; other site 720555003452 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 720555003453 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 720555003454 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 720555003455 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 720555003456 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 720555003457 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 720555003458 RIP metalloprotease RseP; Region: TIGR00054 720555003459 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 720555003460 active site 720555003461 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 720555003462 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 720555003463 protein binding site [polypeptide binding]; other site 720555003464 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 720555003465 putative substrate binding region [chemical binding]; other site 720555003466 prolyl-tRNA synthetase; Provisional; Region: PRK09194 720555003467 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 720555003468 dimer interface [polypeptide binding]; other site 720555003469 motif 1; other site 720555003470 active site 720555003471 motif 2; other site 720555003472 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 720555003473 putative deacylase active site [active] 720555003474 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 720555003475 active site 720555003476 motif 3; other site 720555003477 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 720555003478 anticodon binding site; other site 720555003479 DNA polymerase III PolC; Validated; Region: polC; PRK00448 720555003480 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 720555003481 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 720555003482 generic binding surface II; other site 720555003483 generic binding surface I; other site 720555003484 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 720555003485 active site 720555003486 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 720555003487 active site 720555003488 catalytic site [active] 720555003489 substrate binding site [chemical binding]; other site 720555003490 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 720555003491 ribosome maturation protein RimP; Reviewed; Region: PRK00092 720555003492 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 720555003493 putative oligomer interface [polypeptide binding]; other site 720555003494 putative RNA binding site [nucleotide binding]; other site 720555003495 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 720555003496 NusA N-terminal domain; Region: NusA_N; pfam08529 720555003497 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 720555003498 RNA binding site [nucleotide binding]; other site 720555003499 homodimer interface [polypeptide binding]; other site 720555003500 NusA-like KH domain; Region: KH_5; pfam13184 720555003501 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 720555003502 G-X-X-G motif; other site 720555003503 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 720555003504 putative RNA binding cleft [nucleotide binding]; other site 720555003505 hypothetical protein; Provisional; Region: PRK07714 720555003506 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 720555003507 translation initiation factor IF-2; Region: IF-2; TIGR00487 720555003508 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 720555003509 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 720555003510 G1 box; other site 720555003511 putative GEF interaction site [polypeptide binding]; other site 720555003512 GTP/Mg2+ binding site [chemical binding]; other site 720555003513 Switch I region; other site 720555003514 G2 box; other site 720555003515 G3 box; other site 720555003516 Switch II region; other site 720555003517 G4 box; other site 720555003518 G5 box; other site 720555003519 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 720555003520 Translation-initiation factor 2; Region: IF-2; pfam11987 720555003521 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 720555003522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 720555003523 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 720555003524 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 720555003525 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 720555003526 RNA binding site [nucleotide binding]; other site 720555003527 active site 720555003528 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 720555003529 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 720555003530 active site 720555003531 Riboflavin kinase; Region: Flavokinase; smart00904 720555003532 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 720555003533 16S/18S rRNA binding site [nucleotide binding]; other site 720555003534 S13e-L30e interaction site [polypeptide binding]; other site 720555003535 25S rRNA binding site [nucleotide binding]; other site 720555003536 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 720555003537 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 720555003538 RNase E interface [polypeptide binding]; other site 720555003539 trimer interface [polypeptide binding]; other site 720555003540 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 720555003541 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 720555003542 RNase E interface [polypeptide binding]; other site 720555003543 trimer interface [polypeptide binding]; other site 720555003544 active site 720555003545 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 720555003546 putative nucleic acid binding region [nucleotide binding]; other site 720555003547 G-X-X-G motif; other site 720555003548 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 720555003549 RNA binding site [nucleotide binding]; other site 720555003550 domain interface; other site 720555003551 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 720555003552 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 720555003553 NodB motif; other site 720555003554 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 720555003555 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 720555003556 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 720555003557 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 720555003558 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 720555003559 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 720555003560 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 720555003561 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 720555003562 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 720555003563 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 720555003564 aspartate kinase I; Reviewed; Region: PRK08210 720555003565 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 720555003566 nucleotide binding site [chemical binding]; other site 720555003567 substrate binding site [chemical binding]; other site 720555003568 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 720555003569 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 720555003570 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 720555003571 dihydrodipicolinate synthase; Region: dapA; TIGR00674 720555003572 dimer interface [polypeptide binding]; other site 720555003573 active site 720555003574 catalytic residue [active] 720555003575 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 720555003576 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 720555003577 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 720555003578 Clp protease; Region: CLP_protease; pfam00574 720555003579 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 720555003580 active site 720555003581 YlzJ-like protein; Region: YlzJ; pfam14035 720555003582 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 720555003583 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 720555003584 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 720555003585 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 720555003586 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 720555003587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555003588 DNA-binding site [nucleotide binding]; DNA binding site 720555003589 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 720555003590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555003591 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555003592 putative substrate translocation pore; other site 720555003593 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 720555003594 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 720555003595 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 720555003596 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 720555003597 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 720555003598 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 720555003599 classical (c) SDRs; Region: SDR_c; cd05233 720555003600 NAD(P) binding site [chemical binding]; other site 720555003601 active site 720555003602 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 720555003603 ACT domain; Region: ACT; pfam01842 720555003604 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 720555003605 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 720555003606 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555003607 non-specific DNA binding site [nucleotide binding]; other site 720555003608 salt bridge; other site 720555003609 sequence-specific DNA binding site [nucleotide binding]; other site 720555003610 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 720555003611 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 720555003612 competence damage-inducible protein A; Provisional; Region: PRK00549 720555003613 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 720555003614 putative MPT binding site; other site 720555003615 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 720555003616 recombinase A; Provisional; Region: recA; PRK09354 720555003617 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 720555003618 hexamer interface [polypeptide binding]; other site 720555003619 Walker A motif; other site 720555003620 ATP binding site [chemical binding]; other site 720555003621 Walker B motif; other site 720555003622 Beta-lactamase; Region: Beta-lactamase; pfam00144 720555003623 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 720555003624 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 720555003625 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 720555003626 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 720555003627 Zn2+ binding site [ion binding]; other site 720555003628 Mg2+ binding site [ion binding]; other site 720555003629 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 720555003630 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 720555003631 putative active site [active] 720555003632 metal binding site [ion binding]; metal-binding site 720555003633 homodimer binding site [polypeptide binding]; other site 720555003634 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 720555003635 Threonine dehydrogenase; Region: TDH; cd05281 720555003636 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 720555003637 structural Zn binding site [ion binding]; other site 720555003638 catalytic Zn binding site [ion binding]; other site 720555003639 tetramer interface [polypeptide binding]; other site 720555003640 NADP binding site [chemical binding]; other site 720555003641 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 720555003642 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 720555003643 substrate-cofactor binding pocket; other site 720555003644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555003645 catalytic residue [active] 720555003646 Chloramphenicol acetyltransferase; Region: CAT; cl02008 720555003647 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 720555003648 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 720555003649 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 720555003650 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 720555003651 FeS/SAM binding site; other site 720555003652 TRAM domain; Region: TRAM; cl01282 720555003653 Predicted membrane protein [Function unknown]; Region: COG4550 720555003654 Outer spore coat protein E (CotE); Region: CotE; pfam10628 720555003655 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 720555003656 MutS domain I; Region: MutS_I; pfam01624 720555003657 MutS domain II; Region: MutS_II; pfam05188 720555003658 MutS domain III; Region: MutS_III; pfam05192 720555003659 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 720555003660 Walker A/P-loop; other site 720555003661 ATP binding site [chemical binding]; other site 720555003662 Q-loop/lid; other site 720555003663 ABC transporter signature motif; other site 720555003664 Walker B; other site 720555003665 D-loop; other site 720555003666 H-loop/switch region; other site 720555003667 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 720555003668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555003669 ATP binding site [chemical binding]; other site 720555003670 Mg2+ binding site [ion binding]; other site 720555003671 G-X-G motif; other site 720555003672 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 720555003673 ATP binding site [chemical binding]; other site 720555003674 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 720555003675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555003676 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 720555003677 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 720555003678 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 720555003679 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 720555003680 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 720555003681 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 720555003682 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 720555003683 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 720555003684 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 720555003685 FMN binding site [chemical binding]; other site 720555003686 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 720555003687 substrate binding site [chemical binding]; other site 720555003688 putative catalytic residue [active] 720555003689 acyl carrier protein; Validated; Region: PRK07117 720555003690 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 720555003691 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 720555003692 dimer interface [polypeptide binding]; other site 720555003693 active site 720555003694 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 720555003695 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 720555003696 dimer interface [polypeptide binding]; other site 720555003697 active site 720555003698 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 720555003699 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 720555003700 substrate binding site [chemical binding]; other site 720555003701 oxyanion hole (OAH) forming residues; other site 720555003702 trimer interface [polypeptide binding]; other site 720555003703 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 720555003704 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 720555003705 substrate binding site [chemical binding]; other site 720555003706 oxyanion hole (OAH) forming residues; other site 720555003707 trimer interface [polypeptide binding]; other site 720555003708 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 720555003709 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 720555003710 acyl-activating enzyme (AAE) consensus motif; other site 720555003711 putative AMP binding site [chemical binding]; other site 720555003712 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555003713 Condensation domain; Region: Condensation; pfam00668 720555003714 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555003715 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555003716 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 720555003717 acyl-activating enzyme (AAE) consensus motif; other site 720555003718 AMP binding site [chemical binding]; other site 720555003719 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555003720 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 720555003721 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003722 active site 720555003723 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 720555003724 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 720555003725 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 720555003726 putative NADP binding site [chemical binding]; other site 720555003727 active site 720555003728 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 720555003729 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 720555003730 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 720555003731 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003732 active site 720555003733 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 720555003734 putative NADP binding site [chemical binding]; other site 720555003735 active site 720555003736 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555003737 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003738 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 720555003739 active site 720555003740 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 720555003741 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555003742 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003743 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 720555003744 active site 720555003745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555003746 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 720555003747 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 720555003748 putative NADP binding site [chemical binding]; other site 720555003749 KR domain; Region: KR; pfam08659 720555003750 active site 720555003751 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 720555003752 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003753 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 720555003754 active site 720555003755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555003756 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 720555003757 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 720555003758 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 720555003759 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003760 active site 720555003761 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 720555003762 putative NADP binding site [chemical binding]; other site 720555003763 active site 720555003764 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555003765 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003766 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 720555003767 active site 720555003768 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 720555003769 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 720555003770 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003771 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 720555003772 active site 720555003773 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 720555003774 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 720555003775 putative NADP binding site [chemical binding]; other site 720555003776 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 720555003777 active site 720555003778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555003779 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 720555003780 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 720555003781 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003782 active site 720555003783 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 720555003784 putative NADP binding site [chemical binding]; other site 720555003785 active site 720555003786 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555003787 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003788 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 720555003789 active site 720555003790 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555003791 Condensation domain; Region: Condensation; pfam00668 720555003792 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555003793 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555003794 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555003795 acyl-activating enzyme (AAE) consensus motif; other site 720555003796 AMP binding site [chemical binding]; other site 720555003797 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555003798 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 720555003799 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003800 active site 720555003801 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 720555003802 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 720555003803 putative NADP binding site [chemical binding]; other site 720555003804 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 720555003805 active site 720555003806 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 720555003807 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 720555003808 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003809 active site 720555003810 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 720555003811 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 720555003812 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 720555003813 putative NADP binding site [chemical binding]; other site 720555003814 active site 720555003815 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 720555003816 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 720555003817 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003818 active site 720555003819 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555003820 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 720555003821 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 720555003822 putative NADP binding site [chemical binding]; other site 720555003823 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 720555003824 active site 720555003825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555003826 S-adenosylmethionine binding site [chemical binding]; other site 720555003827 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 720555003828 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003829 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 720555003830 active site 720555003831 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555003832 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555003833 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 720555003834 active site 720555003835 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555003836 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 720555003837 Cytochrome P450; Region: p450; cl12078 720555003838 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 720555003839 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 720555003840 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 720555003841 active site 720555003842 catalytic triad [active] 720555003843 WYL domain; Region: WYL; cl14852 720555003844 Phage-related replication protein [General function prediction only]; Region: COG4195 720555003845 OsmC-like protein; Region: OsmC; cl00767 720555003846 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 720555003847 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 720555003848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555003849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555003850 YmaF family; Region: YmaF; pfam12788 720555003851 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 720555003852 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 720555003853 bacterial Hfq-like; Region: Hfq; cd01716 720555003854 hexamer interface [polypeptide binding]; other site 720555003855 Sm1 motif; other site 720555003856 RNA binding site [nucleotide binding]; other site 720555003857 Sm2 motif; other site 720555003858 YmzC-like protein; Region: YmzC; pfam14157 720555003859 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 720555003860 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 720555003861 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 720555003862 Class I ribonucleotide reductase; Region: RNR_I; cd01679 720555003863 active site 720555003864 dimer interface [polypeptide binding]; other site 720555003865 catalytic residues [active] 720555003866 effector binding site; other site 720555003867 R2 peptide binding site; other site 720555003868 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 720555003869 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 720555003870 dimer interface [polypeptide binding]; other site 720555003871 putative radical transfer pathway; other site 720555003872 diiron center [ion binding]; other site 720555003873 tyrosyl radical; other site 720555003874 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 720555003875 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 720555003876 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 720555003877 active site 720555003878 metal binding site [ion binding]; metal-binding site 720555003879 Sporulation related domain; Region: SPOR; pfam05036 720555003880 stage V sporulation protein K; Region: spore_V_K; TIGR02881 720555003881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555003882 Walker A motif; other site 720555003883 ATP binding site [chemical binding]; other site 720555003884 Walker B motif; other site 720555003885 arginine finger; other site 720555003886 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 720555003887 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 720555003888 HflX GTPase family; Region: HflX; cd01878 720555003889 G1 box; other site 720555003890 GTP/Mg2+ binding site [chemical binding]; other site 720555003891 Switch I region; other site 720555003892 G2 box; other site 720555003893 G3 box; other site 720555003894 Switch II region; other site 720555003895 G4 box; other site 720555003896 G5 box; other site 720555003897 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 720555003898 Aluminium resistance protein; Region: Alum_res; pfam06838 720555003899 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 720555003900 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 720555003901 DNA binding residues [nucleotide binding] 720555003902 putative dimer interface [polypeptide binding]; other site 720555003903 glutamine synthetase, type I; Region: GlnA; TIGR00653 720555003904 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 720555003905 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 720555003906 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 720555003907 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 720555003908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555003909 Coenzyme A binding pocket [chemical binding]; other site 720555003910 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 720555003911 Uncharacterized conserved protein [Function unknown]; Region: COG5444 720555003912 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 720555003913 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 720555003914 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 720555003915 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 720555003916 Coenzyme A binding pocket [chemical binding]; other site 720555003917 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 720555003918 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555003919 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 720555003920 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 720555003921 YolD-like protein; Region: YolD; pfam08863 720555003922 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 720555003923 Y-family of DNA polymerases; Region: PolY; cl12025 720555003924 active site 720555003925 potential frameshift: common BLAST hit: gi|255767474|ref|NP_390033.2| lesion bypass phage DNA polymerase 720555003926 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 720555003927 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 720555003928 active site 720555003929 active site 720555003930 catalytic residues [active] 720555003931 DNA polymerase IV; Reviewed; Region: PRK03103 720555003932 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 720555003933 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 720555003934 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 720555003935 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 720555003936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555003937 active site 720555003938 motif I; other site 720555003939 motif II; other site 720555003940 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 720555003941 DinB family; Region: DinB; pfam05163 720555003942 DinB superfamily; Region: DinB_2; pfam12867 720555003943 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 720555003944 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 720555003945 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 720555003946 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 720555003947 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 720555003948 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555003949 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 720555003950 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555003951 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 720555003952 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 720555003953 active site 720555003954 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 720555003955 VanW like protein; Region: VanW; pfam04294 720555003956 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 720555003957 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 720555003958 dimerization interface [polypeptide binding]; other site 720555003959 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 720555003960 chitosan binding site [chemical binding]; other site 720555003961 catalytic residues [active] 720555003962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555003963 H+ Antiporter protein; Region: 2A0121; TIGR00900 720555003964 putative substrate translocation pore; other site 720555003965 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 720555003966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555003967 Coenzyme A binding pocket [chemical binding]; other site 720555003968 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 720555003969 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 720555003970 DNA binding residues [nucleotide binding] 720555003971 dimer interface [polypeptide binding]; other site 720555003972 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 720555003973 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 720555003974 putative active site [active] 720555003975 putative catalytic site [active] 720555003976 Uncharacterized conserved protein [Function unknown]; Region: COG2135 720555003977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 720555003978 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 720555003979 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 720555003980 LytTr DNA-binding domain; Region: LytTR; smart00850 720555003981 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 720555003982 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 720555003983 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 720555003984 Walker A/P-loop; other site 720555003985 ATP binding site [chemical binding]; other site 720555003986 Q-loop/lid; other site 720555003987 ABC transporter signature motif; other site 720555003988 Walker B; other site 720555003989 D-loop; other site 720555003990 H-loop/switch region; other site 720555003991 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 720555003992 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 720555003993 YoqO-like protein; Region: YoqO; pfam14037 720555003994 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 720555003995 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 720555003996 Protein of unknown function; Region: DUF3658; pfam12395 720555003997 Protein of unknown function (DUF867); Region: DUF867; pfam05908 720555003998 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 720555003999 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 720555004000 YndJ-like protein; Region: YndJ; pfam14158 720555004001 Protein of unknown function (DUF867); Region: DUF867; pfam05908 720555004002 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 720555004003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 720555004004 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 720555004005 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 720555004006 LexA repressor; Validated; Region: PRK00215 720555004007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555004008 putative DNA binding site [nucleotide binding]; other site 720555004009 putative Zn2+ binding site [ion binding]; other site 720555004010 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 720555004011 Catalytic site [active] 720555004012 cell division suppressor protein YneA; Provisional; Region: PRK14125 720555004013 LysM domain; Region: LysM; pfam01476 720555004014 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 720555004015 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 720555004016 catalytic residues [active] 720555004017 catalytic nucleophile [active] 720555004018 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 720555004019 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 720555004020 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 720555004021 TPP-binding site [chemical binding]; other site 720555004022 dimer interface [polypeptide binding]; other site 720555004023 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 720555004024 PYR/PP interface [polypeptide binding]; other site 720555004025 dimer interface [polypeptide binding]; other site 720555004026 TPP binding site [chemical binding]; other site 720555004027 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 720555004028 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 720555004029 hypothetical protein; Provisional; Region: PRK01844 720555004030 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 720555004031 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 720555004032 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 720555004033 Response regulator receiver domain; Region: Response_reg; pfam00072 720555004034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555004035 active site 720555004036 phosphorylation site [posttranslational modification] 720555004037 intermolecular recognition site; other site 720555004038 dimerization interface [polypeptide binding]; other site 720555004039 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 720555004040 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 720555004041 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 720555004042 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 720555004043 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 720555004044 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 720555004045 aconitate hydratase; Validated; Region: PRK09277 720555004046 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 720555004047 substrate binding site [chemical binding]; other site 720555004048 ligand binding site [chemical binding]; other site 720555004049 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 720555004050 substrate binding site [chemical binding]; other site 720555004051 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 720555004052 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 720555004053 catalytic residues [active] 720555004054 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 720555004055 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 720555004056 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 720555004057 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 720555004058 active site 720555004059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 720555004060 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 720555004061 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 720555004062 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 720555004063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555004064 ATP binding site [chemical binding]; other site 720555004065 Mg2+ binding site [ion binding]; other site 720555004066 G-X-G motif; other site 720555004067 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 720555004068 anchoring element; other site 720555004069 dimer interface [polypeptide binding]; other site 720555004070 ATP binding site [chemical binding]; other site 720555004071 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 720555004072 active site 720555004073 putative metal-binding site [ion binding]; other site 720555004074 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 720555004075 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 720555004076 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 720555004077 CAP-like domain; other site 720555004078 active site 720555004079 primary dimer interface [polypeptide binding]; other site 720555004080 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 720555004081 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 720555004082 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 720555004083 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 720555004084 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 720555004085 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 720555004086 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 720555004087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555004088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555004089 phosphorylation site [posttranslational modification] 720555004090 intermolecular recognition site; other site 720555004091 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 720555004092 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 720555004093 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 720555004094 substrate binding site [chemical binding]; other site 720555004095 active site 720555004096 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 720555004097 metal binding site [ion binding]; metal-binding site 720555004098 ligand binding site [chemical binding]; other site 720555004099 Predicted membrane protein [Function unknown]; Region: COG2246 720555004100 GtrA-like protein; Region: GtrA; pfam04138 720555004101 potential frameshift: common BLAST hit: gi|16078879|ref|NP_389700.1| putative UTP-sugar-phosphate uridylyltransferase 720555004102 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 720555004103 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 720555004104 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 720555004105 DHH family; Region: DHH; pfam01368 720555004106 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 720555004107 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 720555004108 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 720555004109 enoyl-CoA hydratase; Provisional; Region: PRK07657 720555004110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 720555004111 substrate binding site [chemical binding]; other site 720555004112 oxyanion hole (OAH) forming residues; other site 720555004113 trimer interface [polypeptide binding]; other site 720555004114 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 720555004115 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 720555004116 active site 720555004117 catalytic residues [active] 720555004118 metal binding site [ion binding]; metal-binding site 720555004119 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 720555004120 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 720555004121 carboxyltransferase (CT) interaction site; other site 720555004122 biotinylation site [posttranslational modification]; other site 720555004123 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 720555004124 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 720555004125 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 720555004126 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 720555004127 AMP-binding domain protein; Validated; Region: PRK08315 720555004128 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 720555004129 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 720555004130 acyl-activating enzyme (AAE) consensus motif; other site 720555004131 acyl-activating enzyme (AAE) consensus motif; other site 720555004132 putative AMP binding site [chemical binding]; other site 720555004133 putative active site [active] 720555004134 putative CoA binding site [chemical binding]; other site 720555004135 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 720555004136 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 720555004137 FAD binding site [chemical binding]; other site 720555004138 homotetramer interface [polypeptide binding]; other site 720555004139 substrate binding pocket [chemical binding]; other site 720555004140 catalytic base [active] 720555004141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 720555004142 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 720555004143 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 720555004144 Condensation domain; Region: Condensation; pfam00668 720555004145 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004146 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 720555004147 acyl-activating enzyme (AAE) consensus motif; other site 720555004148 AMP binding site [chemical binding]; other site 720555004149 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004150 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 720555004151 Condensation domain; Region: Condensation; pfam00668 720555004152 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004153 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004154 acyl-activating enzyme (AAE) consensus motif; other site 720555004155 AMP binding site [chemical binding]; other site 720555004156 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004157 Condensation domain; Region: Condensation; pfam00668 720555004158 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004159 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555004160 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004161 acyl-activating enzyme (AAE) consensus motif; other site 720555004162 AMP binding site [chemical binding]; other site 720555004163 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004164 Condensation domain; Region: Condensation; pfam00668 720555004165 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004166 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555004167 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004168 acyl-activating enzyme (AAE) consensus motif; other site 720555004169 AMP binding site [chemical binding]; other site 720555004170 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004171 Condensation domain; Region: Condensation; pfam00668 720555004172 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 720555004173 Condensation domain; Region: Condensation; pfam00668 720555004174 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004175 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004176 acyl-activating enzyme (AAE) consensus motif; other site 720555004177 AMP binding site [chemical binding]; other site 720555004178 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004179 Condensation domain; Region: Condensation; pfam00668 720555004180 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004181 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555004182 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 720555004183 acyl-activating enzyme (AAE) consensus motif; other site 720555004184 AMP binding site [chemical binding]; other site 720555004185 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004186 Condensation domain; Region: Condensation; pfam00668 720555004187 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 720555004188 Condensation domain; Region: Condensation; pfam00668 720555004189 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004190 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004191 acyl-activating enzyme (AAE) consensus motif; other site 720555004192 AMP binding site [chemical binding]; other site 720555004193 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004194 Condensation domain; Region: Condensation; pfam00668 720555004195 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004196 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555004197 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004198 acyl-activating enzyme (AAE) consensus motif; other site 720555004199 AMP binding site [chemical binding]; other site 720555004200 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004201 Condensation domain; Region: Condensation; pfam00668 720555004202 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004203 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 720555004204 Condensation domain; Region: Condensation; pfam00668 720555004205 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004206 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555004207 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004208 acyl-activating enzyme (AAE) consensus motif; other site 720555004209 AMP binding site [chemical binding]; other site 720555004210 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004211 Condensation domain; Region: Condensation; pfam00668 720555004212 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004213 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555004214 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004215 acyl-activating enzyme (AAE) consensus motif; other site 720555004216 AMP binding site [chemical binding]; other site 720555004217 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004218 Condensation domain; Region: Condensation; pfam00668 720555004219 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004220 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 720555004221 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 720555004222 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 720555004223 heme-binding site [chemical binding]; other site 720555004224 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 720555004225 FAD binding pocket [chemical binding]; other site 720555004226 FAD binding motif [chemical binding]; other site 720555004227 phosphate binding motif [ion binding]; other site 720555004228 beta-alpha-beta structure motif; other site 720555004229 NAD binding pocket [chemical binding]; other site 720555004230 Heme binding pocket [chemical binding]; other site 720555004231 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 720555004232 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 720555004233 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 720555004234 active site 720555004235 catalytic residues [active] 720555004236 potential frameshift: common BLAST hit: gi|308071467|ref|YP_003873072.1| Regulatory protein soxS 720555004237 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 720555004238 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 720555004239 TPR repeat; Region: TPR_11; pfam13414 720555004240 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555004241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555004242 binding surface 720555004243 TPR motif; other site 720555004244 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555004245 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 720555004246 substrate binding site [chemical binding]; other site 720555004247 amidase catalytic site [active] 720555004248 Zn binding residues [ion binding]; other site 720555004249 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555004250 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 720555004251 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 720555004252 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 720555004253 DNA binding site [nucleotide binding] 720555004254 active site 720555004255 Int/Topo IB signature motif; other site 720555004256 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 720555004257 Int/Topo IB signature motif; other site 720555004258 Helix-turn-helix domain; Region: HTH_17; cl17695 720555004259 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 720555004260 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 720555004261 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555004262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555004263 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 720555004264 putative dimerization interface [polypeptide binding]; other site 720555004265 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 720555004266 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 720555004267 NAD(P) binding site [chemical binding]; other site 720555004268 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 720555004269 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 720555004270 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 720555004271 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 720555004272 active site 720555004273 dimer interface [polypeptide binding]; other site 720555004274 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 720555004275 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 720555004276 active site 720555004277 FMN binding site [chemical binding]; other site 720555004278 substrate binding site [chemical binding]; other site 720555004279 3Fe-4S cluster binding site [ion binding]; other site 720555004280 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 720555004281 domain interface; other site 720555004282 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555004283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555004284 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 720555004285 putative dimerization interface [polypeptide binding]; other site 720555004286 gamma-glutamyl kinase; Provisional; Region: PRK13402 720555004287 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 720555004288 nucleotide binding site [chemical binding]; other site 720555004289 homotetrameric interface [polypeptide binding]; other site 720555004290 putative phosphate binding site [ion binding]; other site 720555004291 putative allosteric binding site; other site 720555004292 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 720555004293 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 720555004294 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 720555004295 Replication terminator protein; Region: RTP; pfam02334 720555004296 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 720555004297 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004298 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 720555004299 acyl-activating enzyme (AAE) consensus motif; other site 720555004300 AMP binding site [chemical binding]; other site 720555004301 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004302 Condensation domain; Region: Condensation; pfam00668 720555004303 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004304 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 720555004305 Condensation domain; Region: Condensation; pfam00668 720555004306 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004307 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004308 acyl-activating enzyme (AAE) consensus motif; other site 720555004309 AMP binding site [chemical binding]; other site 720555004310 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004311 Thioesterase domain; Region: Thioesterase; pfam00975 720555004312 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555004313 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004314 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 720555004315 acyl-activating enzyme (AAE) consensus motif; other site 720555004316 AMP binding site [chemical binding]; other site 720555004317 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004318 Condensation domain; Region: Condensation; pfam00668 720555004319 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004320 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 720555004321 Condensation domain; Region: Condensation; pfam00668 720555004322 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004323 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004324 acyl-activating enzyme (AAE) consensus motif; other site 720555004325 AMP binding site [chemical binding]; other site 720555004326 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004327 Condensation domain; Region: Condensation; pfam00668 720555004328 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004329 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 720555004330 Condensation domain; Region: Condensation; pfam00668 720555004331 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004332 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004333 acyl-activating enzyme (AAE) consensus motif; other site 720555004334 AMP binding site [chemical binding]; other site 720555004335 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004336 Condensation domain; Region: Condensation; pfam00668 720555004337 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004338 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555004339 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004340 acyl-activating enzyme (AAE) consensus motif; other site 720555004341 AMP binding site [chemical binding]; other site 720555004342 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004343 Condensation domain; Region: Condensation; pfam00668 720555004344 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004345 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555004346 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 720555004347 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 720555004348 acyl-activating enzyme (AAE) consensus motif; other site 720555004349 putative AMP binding site [chemical binding]; other site 720555004350 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004351 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 720555004352 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 720555004353 active site 720555004354 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004355 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 720555004356 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 720555004357 inhibitor-cofactor binding pocket; inhibition site 720555004358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555004359 catalytic residue [active] 720555004360 Condensation domain; Region: Condensation; pfam00668 720555004361 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004362 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004363 Condensation domain; Region: Condensation; pfam00668 720555004364 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004365 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555004366 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555004367 acyl-activating enzyme (AAE) consensus motif; other site 720555004368 AMP binding site [chemical binding]; other site 720555004369 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555004370 Condensation domain; Region: Condensation; pfam00668 720555004371 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555004372 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555004373 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 720555004374 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 720555004375 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 720555004376 substrate binding site [chemical binding]; other site 720555004377 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 720555004378 Penicillin-binding protein-related factor A, putative recombinase [General function prediction only]; Region: PrfA; COG3331 720555004379 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 720555004380 threonine synthase; Validated; Region: PRK08329 720555004381 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 720555004382 homodimer interface [polypeptide binding]; other site 720555004383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555004384 catalytic residue [active] 720555004385 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 720555004386 homotrimer interaction site [polypeptide binding]; other site 720555004387 putative active site [active] 720555004388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 720555004389 YheO-like PAS domain; Region: PAS_6; pfam08348 720555004390 HTH domain; Region: HTH_22; pfam13309 720555004391 potential frameshift: common BLAST hit: gi|305674499|ref|YP_003866171.1| thymidylate synthase 720555004392 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 720555004393 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 720555004394 trimer interface [polypeptide binding]; other site 720555004395 active site 720555004396 potential frameshift: common BLAST hit: gi|50812253|ref|NP_389886.2| ribonucleotide-diphosphate reductase subunit beta 720555004397 potential frameshift: common BLAST hit: gi|157692409|ref|YP_001486871.1| ribonucleotide-diphosphate reductase subunit alpha 720555004398 potential frameshift: common BLAST hit: gi|50812254|ref|NP_389888.2| SPbeta phage ribonucleoside-diphosphate reductase, alpha subunit 720555004399 potential frameshift: common BLAST hit: gi|50812254|ref|NP_389888.2| SPbeta phage ribonucleoside-diphosphate reductase, alpha subunit 720555004400 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 720555004401 potential frameshift: common BLAST hit: gi|305678702|ref|YP_003864121.1| transposase 720555004402 potential frameshift: common BLAST hit: gi|305678702|ref|YP_003864121.1| transposase 720555004403 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 720555004404 multiple promoter invertase; Provisional; Region: mpi; PRK13413 720555004405 catalytic residues [active] 720555004406 catalytic nucleophile [active] 720555004407 Presynaptic Site I dimer interface [polypeptide binding]; other site 720555004408 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 720555004409 Synaptic Flat tetramer interface [polypeptide binding]; other site 720555004410 Synaptic Site I dimer interface [polypeptide binding]; other site 720555004411 DNA binding site [nucleotide binding] 720555004412 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 720555004413 DNA-binding interface [nucleotide binding]; DNA binding site 720555004414 Predicted transcriptional regulator [Transcription]; Region: COG2378 720555004415 HTH domain; Region: HTH_11; pfam08279 720555004416 WYL domain; Region: WYL; pfam13280 720555004417 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 720555004418 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 720555004419 conserved cys residue [active] 720555004420 Phosphotransferase enzyme family; Region: APH; pfam01636 720555004421 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 720555004422 active site 720555004423 ATP binding site [chemical binding]; other site 720555004424 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 720555004425 YoqO-like protein; Region: YoqO; pfam14037 720555004426 YopX protein; Region: YopX; pfam09643 720555004427 dUTPase; Region: dUTPase_2; pfam08761 720555004428 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 720555004429 active site 720555004430 homodimer interface [polypeptide binding]; other site 720555004431 metal binding site [ion binding]; metal-binding site 720555004432 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 720555004433 Hypothetical protein Yopt; Region: Yopt; pfam09467 720555004434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555004435 salt bridge; other site 720555004436 non-specific DNA binding site [nucleotide binding]; other site 720555004437 sequence-specific DNA binding site [nucleotide binding]; other site 720555004438 DNA-sulfur modification-associated; Region: DndB; pfam14072 720555004439 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 720555004440 active site 720555004441 DNA binding site [nucleotide binding] 720555004442 Int/Topo IB signature motif; other site 720555004443 Helix-turn-helix domain; Region: HTH_19; pfam12844 720555004444 MepB protein; Region: MepB; cl01985 720555004445 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 720555004446 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 720555004447 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 720555004448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555004449 non-specific DNA binding site [nucleotide binding]; other site 720555004450 salt bridge; other site 720555004451 sequence-specific DNA binding site [nucleotide binding]; other site 720555004452 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 720555004453 IHF - DNA interface [nucleotide binding]; other site 720555004454 IHF dimer interface [polypeptide binding]; other site 720555004455 Terminase-like family; Region: Terminase_6; pfam03237 720555004456 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 720555004457 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 720555004458 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 720555004459 active site 720555004460 catalytic site [active] 720555004461 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 720555004462 potential frameshift: common BLAST hit: gi|16079189|ref|NP_390013.1| putative integrase; phage SPbeta 720555004463 AAA domain; Region: AAA_13; pfam13166 720555004464 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 720555004465 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 720555004466 Y-family of DNA polymerases; Region: PolY; cl12025 720555004467 active site 720555004468 YolD-like protein; Region: YolD; pfam08863 720555004469 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 720555004470 LXG domain of WXG superfamily; Region: LXG; pfam04740 720555004471 potential frameshift: common BLAST hit: gi|16078951|ref|NP_389772.1| response regulator aspartate phosphatase 720555004472 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 720555004473 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 720555004474 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 720555004475 conserved cys residue [active] 720555004476 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 720555004477 classical (c) SDRs; Region: SDR_c; cd05233 720555004478 NAD(P) binding site [chemical binding]; other site 720555004479 active site 720555004480 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 720555004481 DinB family; Region: DinB; pfam05163 720555004482 DinB superfamily; Region: DinB_2; pfam12867 720555004483 polyol permease family; Region: 2A0118; TIGR00897 720555004484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555004485 putative substrate translocation pore; other site 720555004486 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 720555004487 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 720555004488 nucleotide binding site [chemical binding]; other site 720555004489 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 720555004490 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 720555004491 putative ligand binding site [chemical binding]; other site 720555004492 putative NAD binding site [chemical binding]; other site 720555004493 catalytic site [active] 720555004494 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 720555004495 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 720555004496 putative [4Fe-4S] binding site [ion binding]; other site 720555004497 putative molybdopterin cofactor binding site [chemical binding]; other site 720555004498 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 720555004499 putative molybdopterin cofactor binding site; other site 720555004500 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 720555004501 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 720555004502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555004503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555004504 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 720555004505 dimer interface [polypeptide binding]; other site 720555004506 putative tRNA-binding site [nucleotide binding]; other site 720555004507 Cupin domain; Region: Cupin_2; pfam07883 720555004508 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 720555004509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555004510 WHG domain; Region: WHG; pfam13305 720555004511 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 720555004512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 720555004513 Predicted transcriptional regulator [Transcription]; Region: COG2378 720555004514 HTH domain; Region: HTH_11; pfam08279 720555004515 WYL domain; Region: WYL; pfam13280 720555004516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555004517 dimerization interface [polypeptide binding]; other site 720555004518 putative DNA binding site [nucleotide binding]; other site 720555004519 putative Zn2+ binding site [ion binding]; other site 720555004520 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 720555004521 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 720555004522 N-acetyl-D-glucosamine binding site [chemical binding]; other site 720555004523 catalytic residue [active] 720555004524 Predicted membrane protein [Function unknown]; Region: COG2322 720555004525 Protein required for attachment to host cells; Region: Host_attach; cl02398 720555004526 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 720555004527 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 720555004528 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 720555004529 putative di-iron ligands [ion binding]; other site 720555004530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 720555004531 Histidine kinase; Region: HisKA_3; pfam07730 720555004532 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 720555004533 ATP binding site [chemical binding]; other site 720555004534 Mg2+ binding site [ion binding]; other site 720555004535 G-X-G motif; other site 720555004536 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 720555004537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555004538 active site 720555004539 phosphorylation site [posttranslational modification] 720555004540 intermolecular recognition site; other site 720555004541 dimerization interface [polypeptide binding]; other site 720555004542 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 720555004543 DNA binding residues [nucleotide binding] 720555004544 dimerization interface [polypeptide binding]; other site 720555004545 potential frameshift: common BLAST hit: gi|305674734|ref|YP_003866406.1| putative symporter 720555004546 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555004547 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 720555004548 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555004549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 720555004550 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 720555004551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 720555004552 ATP binding site [chemical binding]; other site 720555004553 putative Mg++ binding site [ion binding]; other site 720555004554 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555004555 nucleotide binding region [chemical binding]; other site 720555004556 ATP-binding site [chemical binding]; other site 720555004557 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 720555004558 HRDC domain; Region: HRDC; pfam00570 720555004559 azoreductase; Provisional; Region: PRK13556 720555004560 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 720555004561 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 720555004562 pentamer interface [polypeptide binding]; other site 720555004563 dodecaamer interface [polypeptide binding]; other site 720555004564 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 720555004565 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 720555004566 NAD(P) binding site [chemical binding]; other site 720555004567 catalytic residues [active] 720555004568 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 720555004569 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 720555004570 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 720555004571 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 720555004572 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 720555004573 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 720555004574 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 720555004575 Na2 binding site [ion binding]; other site 720555004576 putative substrate binding site 1 [chemical binding]; other site 720555004577 Na binding site 1 [ion binding]; other site 720555004578 putative substrate binding site 2 [chemical binding]; other site 720555004579 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 720555004580 Sodium Bile acid symporter family; Region: SBF; pfam01758 720555004581 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 720555004582 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 720555004583 E3 interaction surface; other site 720555004584 lipoyl attachment site [posttranslational modification]; other site 720555004585 e3 binding domain; Region: E3_binding; pfam02817 720555004586 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 720555004587 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 720555004588 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 720555004589 TPP-binding site [chemical binding]; other site 720555004590 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 720555004591 dimer interface [polypeptide binding]; other site 720555004592 PYR/PP interface [polypeptide binding]; other site 720555004593 TPP binding site [chemical binding]; other site 720555004594 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 720555004595 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 720555004596 metal ion-dependent adhesion site (MIDAS); other site 720555004597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555004598 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 720555004599 Walker A motif; other site 720555004600 ATP binding site [chemical binding]; other site 720555004601 Walker B motif; other site 720555004602 arginine finger; other site 720555004603 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 720555004604 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 720555004605 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 720555004606 P-class dimer interface [polypeptide binding]; other site 720555004607 active site 720555004608 Cu2+ binding site [ion binding]; other site 720555004609 E-class dimer interface [polypeptide binding]; other site 720555004610 Zn2+ binding site [ion binding]; other site 720555004611 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555004612 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555004613 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 720555004614 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555004615 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555004616 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 720555004617 NlpC/P60 family; Region: NLPC_P60; pfam00877 720555004618 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 720555004619 glycosyltransferase, MGT family; Region: MGT; TIGR01426 720555004620 active site 720555004621 TDP-binding site; other site 720555004622 acceptor substrate-binding pocket; other site 720555004623 homodimer interface [polypeptide binding]; other site 720555004624 Uncharacterized conserved protein [Function unknown]; Region: COG1624 720555004625 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 720555004626 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 720555004627 multidrug efflux protein; Reviewed; Region: PRK01766 720555004628 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 720555004629 cation binding site [ion binding]; other site 720555004630 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 720555004631 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 720555004632 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 720555004633 Predicted permeases [General function prediction only]; Region: RarD; COG2962 720555004634 EamA-like transporter family; Region: EamA; pfam00892 720555004635 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 720555004636 putative dimer interface [polypeptide binding]; other site 720555004637 fructuronate transporter; Provisional; Region: PRK10034; cl15264 720555004638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 720555004639 DinB superfamily; Region: DinB_2; pfam12867 720555004640 fructuronate transporter; Provisional; Region: PRK10034; cl15264 720555004641 fructuronate transporter; Provisional; Region: PRK10034; cl15264 720555004642 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 720555004643 Predicted transcriptional regulators [Transcription]; Region: COG1733 720555004644 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555004645 dimerization interface [polypeptide binding]; other site 720555004646 putative DNA binding site [nucleotide binding]; other site 720555004647 putative Zn2+ binding site [ion binding]; other site 720555004648 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 720555004649 dimer interface [polypeptide binding]; other site 720555004650 FMN binding site [chemical binding]; other site 720555004651 Predicted esterase [General function prediction only]; Region: COG0400 720555004652 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 720555004653 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555004654 Zn binding site [ion binding]; other site 720555004655 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 720555004656 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555004657 Zn binding site [ion binding]; other site 720555004658 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 720555004659 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 720555004660 Na binding site [ion binding]; other site 720555004661 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 720555004662 C-terminal peptidase (prc); Region: prc; TIGR00225 720555004663 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 720555004664 protein binding site [polypeptide binding]; other site 720555004665 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 720555004666 Catalytic dyad [active] 720555004667 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 720555004668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555004669 S-adenosylmethionine binding site [chemical binding]; other site 720555004670 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 720555004671 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 720555004672 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 720555004673 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 720555004674 YodL-like; Region: YodL; pfam14191 720555004675 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 720555004676 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 720555004677 active site 720555004678 YozD-like protein; Region: YozD; pfam14162 720555004679 hypothetical protein; Provisional; Region: PRK13672 720555004680 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 720555004681 toxin interface [polypeptide binding]; other site 720555004682 Zn binding site [ion binding]; other site 720555004683 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 720555004684 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 720555004685 FeS/SAM binding site; other site 720555004686 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 720555004687 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 720555004688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555004689 Coenzyme A binding pocket [chemical binding]; other site 720555004690 acetylornithine deacetylase; Validated; Region: PRK06915 720555004691 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 720555004692 metal binding site [ion binding]; metal-binding site 720555004693 dimer interface [polypeptide binding]; other site 720555004694 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 720555004695 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 720555004696 hypothetical protein; Provisional; Region: PRK06917 720555004697 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 720555004698 inhibitor-cofactor binding pocket; inhibition site 720555004699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555004700 catalytic residue [active] 720555004701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555004702 Coenzyme A binding pocket [chemical binding]; other site 720555004703 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 720555004704 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 720555004705 active site 720555004706 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 720555004707 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 720555004708 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 720555004709 Phytase; Region: Phytase; cl17685 720555004710 alanine racemase; Region: alr; TIGR00492 720555004711 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 720555004712 active site 720555004713 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 720555004714 dimer interface [polypeptide binding]; other site 720555004715 substrate binding site [chemical binding]; other site 720555004716 catalytic residues [active] 720555004717 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 720555004718 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 720555004719 active site 720555004720 Ca binding site [ion binding]; other site 720555004721 catalytic site [active] 720555004722 Chitin binding domain; Region: Chitin_bind_3; pfam03067 720555004723 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 720555004724 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555004725 salt bridge; other site 720555004726 non-specific DNA binding site [nucleotide binding]; other site 720555004727 sequence-specific DNA binding site [nucleotide binding]; other site 720555004728 Protein of unknown function (DUF817); Region: DUF817; pfam05675 720555004729 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 720555004730 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 720555004731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 720555004732 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 720555004733 methionine sulfoxide reductase B; Provisional; Region: PRK00222 720555004734 SelR domain; Region: SelR; pfam01641 720555004735 methionine sulfoxide reductase A; Provisional; Region: PRK14054 720555004736 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555004737 MarR family; Region: MarR; pfam01047 720555004738 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 720555004739 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 720555004740 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 720555004741 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 720555004742 active site 720555004743 catalytic triad [active] 720555004744 oxyanion hole [active] 720555004745 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 720555004746 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 720555004747 Cu(I) binding site [ion binding]; other site 720555004748 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 720555004749 threonine dehydratase; Validated; Region: PRK08639 720555004750 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 720555004751 tetramer interface [polypeptide binding]; other site 720555004752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555004753 catalytic residue [active] 720555004754 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 720555004755 putative Ile/Val binding site [chemical binding]; other site 720555004756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555004757 Walker A motif; other site 720555004758 ATP binding site [chemical binding]; other site 720555004759 Walker B motif; other site 720555004760 arginine finger; other site 720555004761 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 720555004762 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 720555004763 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 720555004764 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 720555004765 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 720555004766 putative acyl-acceptor binding pocket; other site 720555004767 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 720555004768 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 720555004769 folate binding site [chemical binding]; other site 720555004770 NADP+ binding site [chemical binding]; other site 720555004771 thymidylate synthase; Reviewed; Region: thyA; PRK01827 720555004772 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 720555004773 dimerization interface [polypeptide binding]; other site 720555004774 active site 720555004775 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 720555004776 tetramer interfaces [polypeptide binding]; other site 720555004777 binuclear metal-binding site [ion binding]; other site 720555004778 YpjP-like protein; Region: YpjP; pfam14005 720555004779 ribosomal biogenesis protein; Validated; Region: PRK00933 720555004780 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 720555004781 Disulphide isomerase; Region: Disulph_isomer; pfam06491 720555004782 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 720555004783 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 720555004784 Virulence factor; Region: Virulence_fact; pfam13769 720555004785 HEAT repeats; Region: HEAT_2; pfam13646 720555004786 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 720555004787 HEAT repeats; Region: HEAT_2; pfam13646 720555004788 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 720555004789 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 720555004790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 720555004791 Zn2+ binding site [ion binding]; other site 720555004792 Mg2+ binding site [ion binding]; other site 720555004793 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 720555004794 catalytic residues [active] 720555004795 dimer interface [polypeptide binding]; other site 720555004796 homoserine O-succinyltransferase; Provisional; Region: PRK05368 720555004797 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 720555004798 proposed active site lysine [active] 720555004799 conserved cys residue [active] 720555004800 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 720555004801 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 720555004802 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 720555004803 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 720555004804 DNA-binding site [nucleotide binding]; DNA binding site 720555004805 RNA-binding motif; other site 720555004806 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 720555004807 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 720555004808 hypothetical protein; Validated; Region: PRK07708 720555004809 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 720555004810 RNA/DNA hybrid binding site [nucleotide binding]; other site 720555004811 active site 720555004812 conserved hypothetical integral membrane protein; Region: TIGR00697 720555004813 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 720555004814 RNA/DNA hybrid binding site [nucleotide binding]; other site 720555004815 active site 720555004816 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 720555004817 5'-3' exonuclease; Region: 53EXOc; smart00475 720555004818 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 720555004819 active site 720555004820 metal binding site 1 [ion binding]; metal-binding site 720555004821 putative 5' ssDNA interaction site; other site 720555004822 metal binding site 3; metal-binding site 720555004823 metal binding site 2 [ion binding]; metal-binding site 720555004824 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 720555004825 putative DNA binding site [nucleotide binding]; other site 720555004826 putative metal binding site [ion binding]; other site 720555004827 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 720555004828 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 720555004829 Dynamin family; Region: Dynamin_N; pfam00350 720555004830 G1 box; other site 720555004831 GTP/Mg2+ binding site [chemical binding]; other site 720555004832 G2 box; other site 720555004833 Switch I region; other site 720555004834 G3 box; other site 720555004835 Switch II region; other site 720555004836 G4 box; other site 720555004837 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 720555004838 G1 box; other site 720555004839 GTP/Mg2+ binding site [chemical binding]; other site 720555004840 Dynamin family; Region: Dynamin_N; pfam00350 720555004841 G2 box; other site 720555004842 Switch I region; other site 720555004843 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 720555004844 G3 box; other site 720555004845 Switch II region; other site 720555004846 GTP/Mg2+ binding site [chemical binding]; other site 720555004847 G4 box; other site 720555004848 G5 box; other site 720555004849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 720555004850 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 720555004851 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 720555004852 malonyl-CoA binding site [chemical binding]; other site 720555004853 dimer interface [polypeptide binding]; other site 720555004854 active site 720555004855 product binding site; other site 720555004856 xanthine permease; Region: pbuX; TIGR03173 720555004857 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 720555004858 active site 720555004859 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 720555004860 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 720555004861 active site 720555004862 Zn binding site [ion binding]; other site 720555004863 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 720555004864 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 720555004865 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 720555004866 active site 720555004867 intersubunit interface [polypeptide binding]; other site 720555004868 catalytic residue [active] 720555004869 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 720555004870 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 720555004871 substrate binding site [chemical binding]; other site 720555004872 ATP binding site [chemical binding]; other site 720555004873 Transcriptional regulators [Transcription]; Region: PurR; COG1609 720555004874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 720555004875 DNA binding site [nucleotide binding] 720555004876 domain linker motif; other site 720555004877 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 720555004878 putative dimerization interface [polypeptide binding]; other site 720555004879 putative ligand binding site [chemical binding]; other site 720555004880 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 720555004881 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 720555004882 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 720555004883 NADP binding site [chemical binding]; other site 720555004884 homodimer interface [polypeptide binding]; other site 720555004885 active site 720555004886 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 720555004887 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 720555004888 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 720555004889 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 720555004890 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 720555004891 cell division protein GpsB; Provisional; Region: PRK14127 720555004892 DivIVA domain; Region: DivI1A_domain; TIGR03544 720555004893 hypothetical protein; Provisional; Region: PRK13660 720555004894 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 720555004895 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 720555004896 RNase_H superfamily; Region: RNase_H_2; pfam13482 720555004897 active site 720555004898 substrate binding site [chemical binding]; other site 720555004899 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 720555004900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 720555004901 ATP binding site [chemical binding]; other site 720555004902 putative Mg++ binding site [ion binding]; other site 720555004903 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555004904 nucleotide binding region [chemical binding]; other site 720555004905 ATP-binding site [chemical binding]; other site 720555004906 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 720555004907 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 720555004908 HPr interaction site; other site 720555004909 glycerol kinase (GK) interaction site [polypeptide binding]; other site 720555004910 active site 720555004911 phosphorylation site [posttranslational modification] 720555004912 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 720555004913 YppG-like protein; Region: YppG; pfam14179 720555004914 YppF-like protein; Region: YppF; pfam14178 720555004915 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 720555004916 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 720555004917 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 720555004918 Transglycosylase; Region: Transgly; pfam00912 720555004919 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 720555004920 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 720555004921 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 720555004922 Interdomain contacts; other site 720555004923 Cytokine receptor motif; other site 720555004924 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 720555004925 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 720555004926 minor groove reading motif; other site 720555004927 helix-hairpin-helix signature motif; other site 720555004928 substrate binding pocket [chemical binding]; other site 720555004929 active site 720555004930 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 720555004931 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 720555004932 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 720555004933 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 720555004934 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 720555004935 putative dimer interface [polypeptide binding]; other site 720555004936 putative anticodon binding site; other site 720555004937 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 720555004938 homodimer interface [polypeptide binding]; other site 720555004939 motif 1; other site 720555004940 motif 2; other site 720555004941 active site 720555004942 motif 3; other site 720555004943 aspartate aminotransferase; Provisional; Region: PRK05764 720555004944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555004945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555004946 homodimer interface [polypeptide binding]; other site 720555004947 catalytic residue [active] 720555004948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 720555004949 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 720555004950 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 720555004951 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 720555004952 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 720555004953 active site 720555004954 catalytic site [active] 720555004955 substrate binding site [chemical binding]; other site 720555004956 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 720555004957 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 720555004958 tetramerization interface [polypeptide binding]; other site 720555004959 active site 720555004960 pantoate--beta-alanine ligase; Region: panC; TIGR00018 720555004961 Pantoate-beta-alanine ligase; Region: PanC; cd00560 720555004962 active site 720555004963 ATP-binding site [chemical binding]; other site 720555004964 pantoate-binding site; other site 720555004965 HXXH motif; other site 720555004966 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 720555004967 oligomerization interface [polypeptide binding]; other site 720555004968 active site 720555004969 metal binding site [ion binding]; metal-binding site 720555004970 Biotin operon repressor [Transcription]; Region: BirA; COG1654 720555004971 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 720555004972 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 720555004973 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 720555004974 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 720555004975 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 720555004976 active site 720555004977 NTP binding site [chemical binding]; other site 720555004978 metal binding triad [ion binding]; metal-binding site 720555004979 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 720555004980 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 720555004981 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 720555004982 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 720555004983 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 720555004984 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 720555004985 active site 720555004986 dimer interfaces [polypeptide binding]; other site 720555004987 catalytic residues [active] 720555004988 dihydrodipicolinate reductase; Provisional; Region: PRK00048 720555004989 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 720555004990 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 720555004991 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 720555004992 homodimer interface [polypeptide binding]; other site 720555004993 metal binding site [ion binding]; metal-binding site 720555004994 Uncharacterized conserved protein [Function unknown]; Region: COG1284 720555004995 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 720555004996 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 720555004997 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 720555004998 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 720555004999 Cupin; Region: Cupin_1; smart00835 720555005000 Cupin; Region: Cupin_1; smart00835 720555005001 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 720555005002 Predicted membrane protein [Function unknown]; Region: COG4347 720555005003 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 720555005004 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 720555005005 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 720555005006 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 720555005007 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 720555005008 interchain domain interface [polypeptide binding]; other site 720555005009 intrachain domain interface; other site 720555005010 heme bH binding site [chemical binding]; other site 720555005011 Qi binding site; other site 720555005012 heme bL binding site [chemical binding]; other site 720555005013 Qo binding site; other site 720555005014 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 720555005015 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 720555005016 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 720555005017 iron-sulfur cluster [ion binding]; other site 720555005018 [2Fe-2S] cluster binding site [ion binding]; other site 720555005019 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 720555005020 hypothetical protein; Provisional; Region: PRK03636 720555005021 UPF0302 domain; Region: UPF0302; pfam08864 720555005022 IDEAL domain; Region: IDEAL; pfam08858 720555005023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555005024 binding surface 720555005025 TPR motif; other site 720555005026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555005027 binding surface 720555005028 TPR motif; other site 720555005029 Tetratricopeptide repeat; Region: TPR_16; pfam13432 720555005030 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 720555005031 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 720555005032 hinge; other site 720555005033 active site 720555005034 prephenate dehydrogenase; Validated; Region: PRK08507 720555005035 prephenate dehydrogenase; Validated; Region: PRK06545 720555005036 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 720555005037 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 720555005038 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555005039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555005040 homodimer interface [polypeptide binding]; other site 720555005041 catalytic residue [active] 720555005042 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 720555005043 substrate binding site [chemical binding]; other site 720555005044 active site 720555005045 catalytic residues [active] 720555005046 heterodimer interface [polypeptide binding]; other site 720555005047 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 720555005048 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 720555005049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555005050 catalytic residue [active] 720555005051 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 720555005052 active site 720555005053 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 720555005054 active site 720555005055 ribulose/triose binding site [chemical binding]; other site 720555005056 phosphate binding site [ion binding]; other site 720555005057 substrate (anthranilate) binding pocket [chemical binding]; other site 720555005058 product (indole) binding pocket [chemical binding]; other site 720555005059 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 720555005060 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 720555005061 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 720555005062 anthranilate synthase component I; Provisional; Region: PRK13569 720555005063 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 720555005064 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 720555005065 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 720555005066 homotrimer interaction site [polypeptide binding]; other site 720555005067 active site 720555005068 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 720555005069 active site 720555005070 dimer interface [polypeptide binding]; other site 720555005071 metal binding site [ion binding]; metal-binding site 720555005072 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 720555005073 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 720555005074 Tetramer interface [polypeptide binding]; other site 720555005075 active site 720555005076 FMN-binding site [chemical binding]; other site 720555005077 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 720555005078 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 720555005079 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 720555005080 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 720555005081 active site 720555005082 multimer interface [polypeptide binding]; other site 720555005083 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 720555005084 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 720555005085 substrate binding pocket [chemical binding]; other site 720555005086 chain length determination region; other site 720555005087 substrate-Mg2+ binding site; other site 720555005088 catalytic residues [active] 720555005089 aspartate-rich region 1; other site 720555005090 active site lid residues [active] 720555005091 aspartate-rich region 2; other site 720555005092 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 720555005093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555005094 S-adenosylmethionine binding site [chemical binding]; other site 720555005095 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 720555005096 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 720555005097 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 720555005098 homodecamer interface [polypeptide binding]; other site 720555005099 GTP cyclohydrolase I; Provisional; Region: PLN03044 720555005100 active site 720555005101 putative catalytic site residues [active] 720555005102 zinc binding site [ion binding]; other site 720555005103 GTP-CH-I/GFRP interaction surface; other site 720555005104 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 720555005105 IHF dimer interface [polypeptide binding]; other site 720555005106 IHF - DNA interface [nucleotide binding]; other site 720555005107 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 720555005108 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 720555005109 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 720555005110 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 720555005111 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 720555005112 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 720555005113 GTP-binding protein Der; Reviewed; Region: PRK00093 720555005114 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 720555005115 G1 box; other site 720555005116 GTP/Mg2+ binding site [chemical binding]; other site 720555005117 Switch I region; other site 720555005118 G2 box; other site 720555005119 Switch II region; other site 720555005120 G3 box; other site 720555005121 G4 box; other site 720555005122 G5 box; other site 720555005123 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 720555005124 G1 box; other site 720555005125 GTP/Mg2+ binding site [chemical binding]; other site 720555005126 Switch I region; other site 720555005127 G2 box; other site 720555005128 G3 box; other site 720555005129 Switch II region; other site 720555005130 G4 box; other site 720555005131 G5 box; other site 720555005132 YIEGIA protein; Region: YIEGIA; pfam14045 720555005133 YpzI-like protein; Region: YpzI; pfam14140 720555005134 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 720555005135 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 720555005136 homotetramer interface [polypeptide binding]; other site 720555005137 FMN binding site [chemical binding]; other site 720555005138 homodimer contacts [polypeptide binding]; other site 720555005139 putative active site [active] 720555005140 putative substrate binding site [chemical binding]; other site 720555005141 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 720555005142 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 720555005143 RNA binding site [nucleotide binding]; other site 720555005144 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 720555005145 RNA binding site [nucleotide binding]; other site 720555005146 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 720555005147 RNA binding site [nucleotide binding]; other site 720555005148 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 720555005149 RNA binding site [nucleotide binding]; other site 720555005150 cytidylate kinase; Provisional; Region: cmk; PRK00023 720555005151 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 720555005152 CMP-binding site; other site 720555005153 The sites determining sugar specificity; other site 720555005154 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 720555005155 Flagellar protein YcgR; Region: YcgR_2; pfam12945 720555005156 PilZ domain; Region: PilZ; pfam07238 720555005157 germination protein YpeB; Region: spore_YpeB; TIGR02889 720555005158 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 720555005159 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 720555005160 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 720555005161 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 720555005162 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 720555005163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555005164 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 720555005165 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 720555005166 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 720555005167 NAD(P) binding site [chemical binding]; other site 720555005168 adaptor protein; Provisional; Region: PRK02899 720555005169 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 720555005170 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 720555005171 putative active site [active] 720555005172 putative metal binding site [ion binding]; other site 720555005173 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 720555005174 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555005175 CAAX protease self-immunity; Region: Abi; pfam02517 720555005176 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 720555005177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 720555005178 ATP binding site [chemical binding]; other site 720555005179 putative Mg++ binding site [ion binding]; other site 720555005180 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555005181 nucleotide binding region [chemical binding]; other site 720555005182 ATP-binding site [chemical binding]; other site 720555005183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 720555005184 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 720555005185 Predicted membrane protein [Function unknown]; Region: COG3601 720555005186 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 720555005187 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 720555005188 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 720555005189 ligand binding site [chemical binding]; other site 720555005190 NAD binding site [chemical binding]; other site 720555005191 dimerization interface [polypeptide binding]; other site 720555005192 catalytic site [active] 720555005193 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 720555005194 putative L-serine binding site [chemical binding]; other site 720555005195 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 720555005196 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 720555005197 active site 720555005198 catalytic residue [active] 720555005199 dimer interface [polypeptide binding]; other site 720555005200 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 720555005201 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555005202 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555005203 DNA binding residues [nucleotide binding] 720555005204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 720555005205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 720555005206 dimerization interface [polypeptide binding]; other site 720555005207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555005208 putative active site [active] 720555005209 heme pocket [chemical binding]; other site 720555005210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555005211 dimer interface [polypeptide binding]; other site 720555005212 phosphorylation site [posttranslational modification] 720555005213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555005214 ATP binding site [chemical binding]; other site 720555005215 Mg2+ binding site [ion binding]; other site 720555005216 G-X-G motif; other site 720555005217 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555005218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555005219 active site 720555005220 phosphorylation site [posttranslational modification] 720555005221 intermolecular recognition site; other site 720555005222 dimerization interface [polypeptide binding]; other site 720555005223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 720555005224 DNA binding site [nucleotide binding] 720555005225 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 720555005226 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 720555005227 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 720555005228 ResB-like family; Region: ResB; pfam05140 720555005229 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 720555005230 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 720555005231 catalytic residues [active] 720555005232 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 720555005233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 720555005234 RNA binding surface [nucleotide binding]; other site 720555005235 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 720555005236 active site 720555005237 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 720555005238 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 720555005239 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 720555005240 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 720555005241 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 720555005242 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 720555005243 segregation and condensation protein B; Region: TIGR00281 720555005244 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 720555005245 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 720555005246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555005247 Coenzyme A binding pocket [chemical binding]; other site 720555005248 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 720555005249 homopentamer interface [polypeptide binding]; other site 720555005250 active site 720555005251 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 720555005252 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 720555005253 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 720555005254 dimerization interface [polypeptide binding]; other site 720555005255 active site 720555005256 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 720555005257 Lumazine binding domain; Region: Lum_binding; pfam00677 720555005258 Lumazine binding domain; Region: Lum_binding; pfam00677 720555005259 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 720555005260 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 720555005261 catalytic motif [active] 720555005262 Zn binding site [ion binding]; other site 720555005263 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 720555005264 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 720555005265 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 720555005266 Catalytic site [active] 720555005267 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 720555005268 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 720555005269 DNA-binding site [nucleotide binding]; DNA binding site 720555005270 RNA-binding motif; other site 720555005271 translocation protein TolB; Provisional; Region: tolB; PRK00178 720555005272 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 720555005273 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 720555005274 Right handed beta helix region; Region: Beta_helix; pfam13229 720555005275 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 720555005276 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 720555005277 catalytic residues [active] 720555005278 catalytic nucleophile [active] 720555005279 Recombinase; Region: Recombinase; pfam07508 720555005280 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 720555005281 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 720555005282 active site 720555005283 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 720555005284 active site 720555005285 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 720555005286 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 720555005287 GIY-YIG motif/motif A; other site 720555005288 active site 720555005289 catalytic site [active] 720555005290 putative DNA binding site [nucleotide binding]; other site 720555005291 metal binding site [ion binding]; metal-binding site 720555005292 3D domain; Region: 3D; cl01439 720555005293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 720555005294 deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575 720555005295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555005296 non-specific DNA binding site [nucleotide binding]; other site 720555005297 salt bridge; other site 720555005298 sequence-specific DNA binding site [nucleotide binding]; other site 720555005299 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 720555005300 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 720555005301 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 720555005302 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 720555005303 active site 720555005304 catalytic site [active] 720555005305 substrate binding site [chemical binding]; other site 720555005306 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 720555005307 active site 720555005308 DNA binding site [nucleotide binding] 720555005309 catalytic site [active] 720555005310 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 720555005311 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 720555005312 Substrate-binding site [chemical binding]; other site 720555005313 Substrate specificity [chemical binding]; other site 720555005314 thymidine kinase; Provisional; Region: PRK04296 720555005315 RNA ligase; Region: RNA_ligase; pfam09414 720555005316 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 720555005317 active site 720555005318 putative DNA-binding cleft [nucleotide binding]; other site 720555005319 dimer interface [polypeptide binding]; other site 720555005320 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555005321 DNA primase, catalytic core; Region: dnaG; TIGR01391 720555005322 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 720555005323 active site 720555005324 metal binding site [ion binding]; metal-binding site 720555005325 interdomain interaction site; other site 720555005326 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 720555005327 Walker A motif; other site 720555005328 ATP binding site [chemical binding]; other site 720555005329 Walker B motif; other site 720555005330 hypothetical protein; Validated; Region: PRK08116 720555005331 Helix-turn-helix domain; Region: HTH_36; pfam13730 720555005332 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 720555005333 amidase catalytic site [active] 720555005334 Zn binding residues [ion binding]; other site 720555005335 substrate binding site [chemical binding]; other site 720555005336 Holin family; Region: Phage_holin_4; pfam05105 720555005337 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 720555005338 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 720555005339 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 720555005340 Phage tail protein; Region: Sipho_tail; pfam05709 720555005341 Bacterial SH3 domain; Region: SH3_3; cl17532 720555005342 Phage tail protein; Region: Sipho_tail; cl17486 720555005343 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 720555005344 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 720555005345 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 720555005346 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 720555005347 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 720555005348 Terminase-like family; Region: Terminase_6; pfam03237 720555005349 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 720555005350 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 720555005351 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 720555005352 catalytic residues [active] 720555005353 catalytic nucleophile [active] 720555005354 Presynaptic Site I dimer interface [polypeptide binding]; other site 720555005355 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 720555005356 Synaptic Flat tetramer interface [polypeptide binding]; other site 720555005357 Synaptic Site I dimer interface [polypeptide binding]; other site 720555005358 DNA binding site [nucleotide binding] 720555005359 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 720555005360 DNA-binding interface [nucleotide binding]; DNA binding site 720555005361 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 720555005362 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 720555005363 YcfA-like protein; Region: YcfA; pfam07927 720555005364 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 720555005365 Predicted secreted protein [Function unknown]; Region: COG4086 720555005366 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 720555005367 diaminopimelate decarboxylase; Region: lysA; TIGR01048 720555005368 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 720555005369 active site 720555005370 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 720555005371 substrate binding site [chemical binding]; other site 720555005372 catalytic residues [active] 720555005373 dimer interface [polypeptide binding]; other site 720555005374 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 720555005375 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 720555005376 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 720555005377 stage V sporulation protein AD; Validated; Region: PRK08304 720555005378 stage V sporulation protein AD; Provisional; Region: PRK12404 720555005379 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 720555005380 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 720555005381 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 720555005382 sporulation sigma factor SigF; Validated; Region: PRK05572 720555005383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555005384 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 720555005385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555005386 DNA binding residues [nucleotide binding] 720555005387 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 720555005388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555005389 ATP binding site [chemical binding]; other site 720555005390 Mg2+ binding site [ion binding]; other site 720555005391 G-X-G motif; other site 720555005392 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 720555005393 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 720555005394 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 720555005395 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 720555005396 purine nucleoside phosphorylase; Provisional; Region: PRK08202 720555005397 phosphopentomutase; Provisional; Region: PRK05362 720555005398 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 720555005399 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 720555005400 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 720555005401 active site 720555005402 Int/Topo IB signature motif; other site 720555005403 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 720555005404 ferric uptake regulator; Provisional; Region: fur; PRK09462 720555005405 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 720555005406 metal binding site 2 [ion binding]; metal-binding site 720555005407 putative DNA binding helix; other site 720555005408 metal binding site 1 [ion binding]; metal-binding site 720555005409 dimer interface [polypeptide binding]; other site 720555005410 structural Zn2+ binding site [ion binding]; other site 720555005411 stage II sporulation protein M; Region: spo_II_M; TIGR02831 720555005412 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 720555005413 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 720555005414 Malic enzyme, N-terminal domain; Region: malic; pfam00390 720555005415 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 720555005416 NAD(P) binding pocket [chemical binding]; other site 720555005417 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 720555005418 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 720555005419 Aspartase; Region: Aspartase; cd01357 720555005420 active sites [active] 720555005421 tetramer interface [polypeptide binding]; other site 720555005422 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 720555005423 active site 720555005424 homodimer interface [polypeptide binding]; other site 720555005425 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 720555005426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555005427 non-specific DNA binding site [nucleotide binding]; other site 720555005428 salt bridge; other site 720555005429 sequence-specific DNA binding site [nucleotide binding]; other site 720555005430 TIGR00375 family protein; Region: TIGR00375 720555005431 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 720555005432 PHP-associated; Region: PHP_C; pfam13263 720555005433 Y-family of DNA polymerases; Region: PolY; cl12025 720555005434 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 720555005435 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 720555005436 dimer interface [polypeptide binding]; other site 720555005437 ADP-ribose binding site [chemical binding]; other site 720555005438 active site 720555005439 nudix motif; other site 720555005440 metal binding site [ion binding]; metal-binding site 720555005441 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 720555005442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 720555005443 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 720555005444 active site 720555005445 catalytic tetrad [active] 720555005446 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 720555005447 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 720555005448 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 720555005449 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 720555005450 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 720555005451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 720555005452 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 720555005453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555005454 Coenzyme A binding pocket [chemical binding]; other site 720555005455 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 720555005456 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 720555005457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555005458 Coenzyme A binding pocket [chemical binding]; other site 720555005459 YolD-like protein; Region: YolD; pfam08863 720555005460 DNA polymerase IV; Reviewed; Region: PRK03103 720555005461 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 720555005462 active site 720555005463 DNA binding site [nucleotide binding] 720555005464 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 720555005465 YqzH-like protein; Region: YqzH; pfam14164 720555005466 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 720555005467 Domain of unknown function DUF20; Region: UPF0118; pfam01594 720555005468 potential frameshift: common BLAST hit: gi|305675018|ref|YP_003866690.1| putative efflux transporter 720555005469 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 720555005470 putative dimer interface [polypeptide binding]; other site 720555005471 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555005472 ligand binding site [chemical binding]; other site 720555005473 Zn binding site [ion binding]; other site 720555005474 pantothenate kinase; Provisional; Region: PRK05439 720555005475 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 720555005476 ATP-binding site [chemical binding]; other site 720555005477 CoA-binding site [chemical binding]; other site 720555005478 Mg2+-binding site [ion binding]; other site 720555005479 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 720555005480 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 720555005481 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 720555005482 NADP binding site [chemical binding]; other site 720555005483 homodimer interface [polypeptide binding]; other site 720555005484 substrate binding site [chemical binding]; other site 720555005485 active site 720555005486 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 720555005487 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 720555005488 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 720555005489 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 720555005490 putative metal binding site [ion binding]; other site 720555005491 putative dimer interface [polypeptide binding]; other site 720555005492 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 720555005493 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 720555005494 active site 720555005495 FMN binding site [chemical binding]; other site 720555005496 substrate binding site [chemical binding]; other site 720555005497 homotetramer interface [polypeptide binding]; other site 720555005498 catalytic residue [active] 720555005499 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 720555005500 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 720555005501 ribonuclease Z; Region: RNase_Z; TIGR02651 720555005502 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 720555005503 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 720555005504 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 720555005505 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 720555005506 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 720555005507 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 720555005508 DNA polymerase IV; Validated; Region: PRK01810 720555005509 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 720555005510 active site 720555005511 DNA binding site [nucleotide binding] 720555005512 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 720555005513 OxaA-like protein precursor; Validated; Region: PRK01622 720555005514 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 720555005515 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 720555005516 peptidase T-like protein; Region: PepT-like; TIGR01883 720555005517 metal binding site [ion binding]; metal-binding site 720555005518 putative dimer interface [polypeptide binding]; other site 720555005519 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 720555005520 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 720555005521 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 720555005522 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555005523 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 720555005524 dimer interface [polypeptide binding]; other site 720555005525 substrate binding site [chemical binding]; other site 720555005526 metal binding site [ion binding]; metal-binding site 720555005527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 720555005528 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 720555005529 Predicted membrane protein [Function unknown]; Region: COG4129 720555005530 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 720555005531 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 720555005532 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 720555005533 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 720555005534 Walker A/P-loop; other site 720555005535 ATP binding site [chemical binding]; other site 720555005536 Q-loop/lid; other site 720555005537 ABC transporter signature motif; other site 720555005538 Walker B; other site 720555005539 D-loop; other site 720555005540 H-loop/switch region; other site 720555005541 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 720555005542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555005543 dimer interface [polypeptide binding]; other site 720555005544 conserved gate region; other site 720555005545 putative PBP binding loops; other site 720555005546 ABC-ATPase subunit interface; other site 720555005547 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 720555005548 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 720555005549 substrate binding pocket [chemical binding]; other site 720555005550 membrane-bound complex binding site; other site 720555005551 hinge residues; other site 720555005552 Disulphide isomerase; Region: Disulph_isomer; pfam06491 720555005553 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 720555005554 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 720555005555 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 720555005556 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 720555005557 E3 interaction surface; other site 720555005558 lipoyl attachment site [posttranslational modification]; other site 720555005559 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 720555005560 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 720555005561 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 720555005562 alpha subunit interface [polypeptide binding]; other site 720555005563 TPP binding site [chemical binding]; other site 720555005564 heterodimer interface [polypeptide binding]; other site 720555005565 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 720555005566 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 720555005567 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 720555005568 tetramer interface [polypeptide binding]; other site 720555005569 TPP-binding site [chemical binding]; other site 720555005570 heterodimer interface [polypeptide binding]; other site 720555005571 phosphorylation loop region [posttranslational modification] 720555005572 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 720555005573 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 720555005574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555005575 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 720555005576 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 720555005577 nucleotide binding site [chemical binding]; other site 720555005578 Acetokinase family; Region: Acetate_kinase; cl17229 720555005579 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 720555005580 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 720555005581 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 720555005582 NAD binding site [chemical binding]; other site 720555005583 Phe binding site; other site 720555005584 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 720555005585 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 720555005586 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 720555005587 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555005588 putative active site [active] 720555005589 heme pocket [chemical binding]; other site 720555005590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555005591 putative active site [active] 720555005592 heme pocket [chemical binding]; other site 720555005593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555005594 Walker A motif; other site 720555005595 ATP binding site [chemical binding]; other site 720555005596 Walker B motif; other site 720555005597 arginine finger; other site 720555005598 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 720555005599 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 720555005600 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 720555005601 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 720555005602 tetramer interface [polypeptide binding]; other site 720555005603 active site 720555005604 Mg2+/Mn2+ binding site [ion binding]; other site 720555005605 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 720555005606 2-methylcitrate dehydratase; Region: prpD; TIGR02330 720555005607 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 720555005608 dimer interface [polypeptide binding]; other site 720555005609 Citrate synthase; Region: Citrate_synt; pfam00285 720555005610 active site 720555005611 coenzyme A binding site [chemical binding]; other site 720555005612 citrylCoA binding site [chemical binding]; other site 720555005613 oxalacetate/citrate binding site [chemical binding]; other site 720555005614 catalytic triad [active] 720555005615 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 720555005616 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 720555005617 FAD binding site [chemical binding]; other site 720555005618 homotetramer interface [polypeptide binding]; other site 720555005619 substrate binding pocket [chemical binding]; other site 720555005620 catalytic base [active] 720555005621 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 720555005622 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 720555005623 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 720555005624 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 720555005625 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 720555005626 dimer interface [polypeptide binding]; other site 720555005627 active site 720555005628 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 720555005629 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 720555005630 active site 720555005631 catalytic site [active] 720555005632 metal binding site [ion binding]; metal-binding site 720555005633 dimer interface [polypeptide binding]; other site 720555005634 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 720555005635 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 720555005636 active site 720555005637 metal binding site [ion binding]; metal-binding site 720555005638 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 720555005639 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 720555005640 putative active site [active] 720555005641 putative FMN binding site [chemical binding]; other site 720555005642 putative substrate binding site [chemical binding]; other site 720555005643 putative catalytic residue [active] 720555005644 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 720555005645 dimanganese center [ion binding]; other site 720555005646 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 720555005647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555005648 active site 720555005649 phosphorylation site [posttranslational modification] 720555005650 intermolecular recognition site; other site 720555005651 dimerization interface [polypeptide binding]; other site 720555005652 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 720555005653 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 720555005654 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 720555005655 protein binding site [polypeptide binding]; other site 720555005656 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 720555005657 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 720555005658 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 720555005659 Walker A/P-loop; other site 720555005660 ATP binding site [chemical binding]; other site 720555005661 Q-loop/lid; other site 720555005662 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 720555005663 ABC transporter signature motif; other site 720555005664 Walker B; other site 720555005665 D-loop; other site 720555005666 H-loop/switch region; other site 720555005667 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 720555005668 arginine repressor; Provisional; Region: PRK04280 720555005669 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 720555005670 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 720555005671 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 720555005672 RNA binding surface [nucleotide binding]; other site 720555005673 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 720555005674 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 720555005675 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 720555005676 TPP-binding site; other site 720555005677 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 720555005678 PYR/PP interface [polypeptide binding]; other site 720555005679 dimer interface [polypeptide binding]; other site 720555005680 TPP binding site [chemical binding]; other site 720555005681 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 720555005682 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 720555005683 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 720555005684 substrate binding pocket [chemical binding]; other site 720555005685 chain length determination region; other site 720555005686 substrate-Mg2+ binding site; other site 720555005687 catalytic residues [active] 720555005688 aspartate-rich region 1; other site 720555005689 active site lid residues [active] 720555005690 aspartate-rich region 2; other site 720555005691 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 720555005692 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 720555005693 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 720555005694 generic binding surface II; other site 720555005695 generic binding surface I; other site 720555005696 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 720555005697 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 720555005698 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 720555005699 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 720555005700 homodimer interface [polypeptide binding]; other site 720555005701 NADP binding site [chemical binding]; other site 720555005702 substrate binding site [chemical binding]; other site 720555005703 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 720555005704 putative RNA binding site [nucleotide binding]; other site 720555005705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 720555005706 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 720555005707 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 720555005708 ATP-grasp domain; Region: ATP-grasp_4; cl17255 720555005709 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 720555005710 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 720555005711 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 720555005712 carboxyltransferase (CT) interaction site; other site 720555005713 biotinylation site [posttranslational modification]; other site 720555005714 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 720555005715 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 720555005716 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 720555005717 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 720555005718 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 720555005719 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 720555005720 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 720555005721 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 720555005722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555005723 Walker A motif; other site 720555005724 ATP binding site [chemical binding]; other site 720555005725 Walker B motif; other site 720555005726 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 720555005727 elongation factor P; Validated; Region: PRK00529 720555005728 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 720555005729 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 720555005730 RNA binding site [nucleotide binding]; other site 720555005731 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 720555005732 RNA binding site [nucleotide binding]; other site 720555005733 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 720555005734 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 720555005735 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 720555005736 active site 720555005737 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 720555005738 Dehydroquinase class II; Region: DHquinase_II; pfam01220 720555005739 trimer interface [polypeptide binding]; other site 720555005740 active site 720555005741 dimer interface [polypeptide binding]; other site 720555005742 Conserved membrane protein YqhR; Region: YqhR; pfam11085 720555005743 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 720555005744 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 720555005745 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 720555005746 active site 720555005747 nucleophile elbow; other site 720555005748 manganese transport transcriptional regulator; Provisional; Region: PRK03902 720555005749 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 720555005750 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 720555005751 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 720555005752 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 720555005753 active site residue [active] 720555005754 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 720555005755 tetramer interface [polypeptide binding]; other site 720555005756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555005757 catalytic residue [active] 720555005758 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 720555005759 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 720555005760 tetramer interface [polypeptide binding]; other site 720555005761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555005762 catalytic residue [active] 720555005763 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 720555005764 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 720555005765 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 720555005766 DEAD-like helicases superfamily; Region: DEXDc; smart00487 720555005767 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 720555005768 ATP binding site [chemical binding]; other site 720555005769 putative Mg++ binding site [ion binding]; other site 720555005770 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555005771 nucleotide binding region [chemical binding]; other site 720555005772 ATP-binding site [chemical binding]; other site 720555005773 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 720555005774 Anti-repressor SinI; Region: SinI; pfam08671 720555005775 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 720555005776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555005777 non-specific DNA binding site [nucleotide binding]; other site 720555005778 salt bridge; other site 720555005779 sequence-specific DNA binding site [nucleotide binding]; other site 720555005780 Anti-repressor SinI; Region: SinI; pfam08671 720555005781 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 720555005782 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 720555005783 Catalytic site [active] 720555005784 YqxM protein; Region: YqxM_for_SipW; TIGR04087 720555005785 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 720555005786 YqzE-like protein; Region: YqzE; pfam14038 720555005787 ComG operon protein 7; Region: ComGG; pfam14173 720555005788 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 720555005789 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 720555005790 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 720555005791 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 720555005792 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 720555005793 Type II/IV secretion system protein; Region: T2SE; pfam00437 720555005794 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 720555005795 Walker A motif; other site 720555005796 ATP binding site [chemical binding]; other site 720555005797 Walker B motif; other site 720555005798 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 720555005799 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 720555005800 Cl binding site [ion binding]; other site 720555005801 oligomer interface [polypeptide binding]; other site 720555005802 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 720555005803 Domain of unknown function DUF21; Region: DUF21; pfam01595 720555005804 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 720555005805 Transporter associated domain; Region: CorC_HlyC; smart01091 720555005806 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 720555005807 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 720555005808 ArsC family; Region: ArsC; pfam03960 720555005809 putative catalytic residues [active] 720555005810 thiol/disulfide switch; other site 720555005811 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 720555005812 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 720555005813 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 720555005814 Domain of unknown function DUF77; Region: DUF77; pfam01910 720555005815 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 720555005816 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 720555005817 putative active site [active] 720555005818 Zn binding site [ion binding]; other site 720555005819 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 720555005820 Sulfatase; Region: Sulfatase; pfam00884 720555005821 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 720555005822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 720555005823 nucleotide binding site [chemical binding]; other site 720555005824 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 720555005825 Rhomboid family; Region: Rhomboid; pfam01694 720555005826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555005827 binding surface 720555005828 TPR motif; other site 720555005829 TPR repeat; Region: TPR_11; pfam13414 720555005830 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 720555005831 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 720555005832 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 720555005833 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 720555005834 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 720555005835 YceG-like family; Region: YceG; pfam02618 720555005836 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 720555005837 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 720555005838 Walker A/P-loop; other site 720555005839 ATP binding site [chemical binding]; other site 720555005840 Q-loop/lid; other site 720555005841 ABC transporter signature motif; other site 720555005842 Walker B; other site 720555005843 D-loop; other site 720555005844 H-loop/switch region; other site 720555005845 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 720555005846 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 720555005847 Walker A/P-loop; other site 720555005848 ATP binding site [chemical binding]; other site 720555005849 Q-loop/lid; other site 720555005850 ABC transporter signature motif; other site 720555005851 Walker B; other site 720555005852 D-loop; other site 720555005853 H-loop/switch region; other site 720555005854 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 720555005855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555005856 dimer interface [polypeptide binding]; other site 720555005857 conserved gate region; other site 720555005858 ABC-ATPase subunit interface; other site 720555005859 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 720555005860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555005861 dimer interface [polypeptide binding]; other site 720555005862 conserved gate region; other site 720555005863 putative PBP binding loops; other site 720555005864 ABC-ATPase subunit interface; other site 720555005865 PBP superfamily domain; Region: PBP_like_2; cl17296 720555005866 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 720555005867 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 720555005868 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 720555005869 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 720555005870 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 720555005871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555005872 putative substrate translocation pore; other site 720555005873 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555005874 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 720555005875 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 720555005876 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 720555005877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 720555005878 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 720555005879 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555005880 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 720555005881 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 720555005882 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 720555005883 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 720555005884 Uncharacterized conserved protein [Function unknown]; Region: COG5663 720555005885 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 720555005886 metal binding site 2 [ion binding]; metal-binding site 720555005887 putative DNA binding helix; other site 720555005888 metal binding site 1 [ion binding]; metal-binding site 720555005889 dimer interface [polypeptide binding]; other site 720555005890 structural Zn2+ binding site [ion binding]; other site 720555005891 Uncharacterized conserved protein [Function unknown]; Region: COG1284 720555005892 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 720555005893 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 720555005894 endonuclease IV; Provisional; Region: PRK01060 720555005895 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 720555005896 AP (apurinic/apyrimidinic) site pocket; other site 720555005897 DNA interaction; other site 720555005898 Metal-binding active site; metal-binding site 720555005899 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 720555005900 DEAD-like helicases superfamily; Region: DEXDc; smart00487 720555005901 ATP binding site [chemical binding]; other site 720555005902 Mg++ binding site [ion binding]; other site 720555005903 motif III; other site 720555005904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555005905 nucleotide binding region [chemical binding]; other site 720555005906 ATP-binding site [chemical binding]; other site 720555005907 YqfQ-like protein; Region: YqfQ; pfam14181 720555005908 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 720555005909 LytB protein; Region: LYTB; pfam02401 720555005910 Uncharacterized conserved protein [Function unknown]; Region: COG0327 720555005911 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 720555005912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 720555005913 Uncharacterized conserved protein [Function unknown]; Region: COG0327 720555005914 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 720555005915 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 720555005916 Family of unknown function (DUF633); Region: DUF633; pfam04816 720555005917 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 720555005918 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 720555005919 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 720555005920 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 720555005921 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 720555005922 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555005923 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 720555005924 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555005925 DNA binding residues [nucleotide binding] 720555005926 DNA primase; Validated; Region: dnaG; PRK05667 720555005927 CHC2 zinc finger; Region: zf-CHC2; pfam01807 720555005928 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 720555005929 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 720555005930 active site 720555005931 metal binding site [ion binding]; metal-binding site 720555005932 interdomain interaction site; other site 720555005933 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 720555005934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 720555005935 PEP synthetase regulatory protein; Provisional; Region: PRK05339 720555005936 HTH domain; Region: HTH_11; pfam08279 720555005937 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 720555005938 FOG: CBS domain [General function prediction only]; Region: COG0517 720555005939 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 720555005940 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 720555005941 dimer interface [polypeptide binding]; other site 720555005942 motif 1; other site 720555005943 active site 720555005944 motif 2; other site 720555005945 motif 3; other site 720555005946 Recombination protein O N terminal; Region: RecO_N; pfam11967 720555005947 DNA repair protein RecO; Region: reco; TIGR00613 720555005948 Recombination protein O C terminal; Region: RecO_C; pfam02565 720555005949 YqzL-like protein; Region: YqzL; pfam14006 720555005950 GTPase Era; Reviewed; Region: era; PRK00089 720555005951 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 720555005952 G1 box; other site 720555005953 GTP/Mg2+ binding site [chemical binding]; other site 720555005954 Switch I region; other site 720555005955 G2 box; other site 720555005956 Switch II region; other site 720555005957 G3 box; other site 720555005958 G4 box; other site 720555005959 G5 box; other site 720555005960 KH domain; Region: KH_2; pfam07650 720555005961 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 720555005962 active site 720555005963 catalytic motif [active] 720555005964 Zn binding site [ion binding]; other site 720555005965 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 720555005966 metal-binding heat shock protein; Provisional; Region: PRK00016 720555005967 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 720555005968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555005969 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 720555005970 Zn2+ binding site [ion binding]; other site 720555005971 Mg2+ binding site [ion binding]; other site 720555005972 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 720555005973 PhoH-like protein; Region: PhoH; pfam02562 720555005974 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 720555005975 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 720555005976 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 720555005977 hypothetical protein; Provisional; Region: PRK13665 720555005978 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 720555005979 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 720555005980 dimer interface [polypeptide binding]; other site 720555005981 active site residues [active] 720555005982 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 720555005983 Yqey-like protein; Region: YqeY; pfam09424 720555005984 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 720555005985 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 720555005986 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 720555005987 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 720555005988 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 720555005989 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 720555005990 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 720555005991 FeS/SAM binding site; other site 720555005992 TRAM domain; Region: TRAM; cl01282 720555005993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 720555005994 RNA methyltransferase, RsmE family; Region: TIGR00046 720555005995 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 720555005996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555005997 S-adenosylmethionine binding site [chemical binding]; other site 720555005998 chaperone protein DnaJ; Provisional; Region: PRK14280 720555005999 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 720555006000 HSP70 interaction site [polypeptide binding]; other site 720555006001 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 720555006002 substrate binding site [polypeptide binding]; other site 720555006003 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 720555006004 Zn binding sites [ion binding]; other site 720555006005 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 720555006006 dimer interface [polypeptide binding]; other site 720555006007 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 720555006008 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 720555006009 nucleotide binding site [chemical binding]; other site 720555006010 NEF interaction site [polypeptide binding]; other site 720555006011 SBD interface [polypeptide binding]; other site 720555006012 heat shock protein GrpE; Provisional; Region: PRK14140 720555006013 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 720555006014 dimer interface [polypeptide binding]; other site 720555006015 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 720555006016 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 720555006017 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 720555006018 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 720555006019 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 720555006020 FeS/SAM binding site; other site 720555006021 HemN C-terminal domain; Region: HemN_C; pfam06969 720555006022 GTP-binding protein LepA; Provisional; Region: PRK05433 720555006023 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 720555006024 G1 box; other site 720555006025 putative GEF interaction site [polypeptide binding]; other site 720555006026 GTP/Mg2+ binding site [chemical binding]; other site 720555006027 Switch I region; other site 720555006028 G2 box; other site 720555006029 G3 box; other site 720555006030 Switch II region; other site 720555006031 G4 box; other site 720555006032 G5 box; other site 720555006033 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 720555006034 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 720555006035 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 720555006036 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 720555006037 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 720555006038 stage II sporulation protein P; Region: spore_II_P; TIGR02867 720555006039 germination protease; Provisional; Region: PRK02858 720555006040 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 720555006041 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 720555006042 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 720555006043 YqzM-like protein; Region: YqzM; pfam14141 720555006044 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 720555006045 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 720555006046 Competence protein; Region: Competence; pfam03772 720555006047 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 720555006048 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 720555006049 catalytic motif [active] 720555006050 Zn binding site [ion binding]; other site 720555006051 SLBB domain; Region: SLBB; pfam10531 720555006052 comEA protein; Region: comE; TIGR01259 720555006053 Helix-hairpin-helix motif; Region: HHH; pfam00633 720555006054 late competence protein ComER; Validated; Region: PRK07680 720555006055 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 720555006056 Methyltransferase domain; Region: Methyltransf_31; pfam13847 720555006057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555006058 S-adenosylmethionine binding site [chemical binding]; other site 720555006059 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 720555006060 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 720555006061 Zn2+ binding site [ion binding]; other site 720555006062 Mg2+ binding site [ion binding]; other site 720555006063 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 720555006064 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 720555006065 active site 720555006066 (T/H)XGH motif; other site 720555006067 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 720555006068 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 720555006069 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 720555006070 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 720555006071 shikimate binding site; other site 720555006072 NAD(P) binding site [chemical binding]; other site 720555006073 GTPase YqeH; Provisional; Region: PRK13796 720555006074 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 720555006075 GTP/Mg2+ binding site [chemical binding]; other site 720555006076 G4 box; other site 720555006077 G5 box; other site 720555006078 G1 box; other site 720555006079 Switch I region; other site 720555006080 G2 box; other site 720555006081 G3 box; other site 720555006082 Switch II region; other site 720555006083 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 720555006084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555006085 active site 720555006086 motif I; other site 720555006087 motif II; other site 720555006088 Sporulation inhibitor A; Region: Sda; pfam08970 720555006089 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 720555006090 active site 720555006091 catalytic triad [active] 720555006092 oxyanion hole [active] 720555006093 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 720555006094 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 720555006095 NodB motif; other site 720555006096 active site 720555006097 catalytic site [active] 720555006098 metal binding site [ion binding]; metal-binding site 720555006099 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 720555006100 homodimer interaction site [polypeptide binding]; other site 720555006101 cofactor binding site; other site 720555006102 Uncharacterized conserved protein [Function unknown]; Region: COG0398 720555006103 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 720555006104 sporulation sigma factor SigK; Reviewed; Region: PRK05803 720555006105 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555006106 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555006107 DNA binding residues [nucleotide binding] 720555006108 LXG domain of WXG superfamily; Region: LXG; pfam04740 720555006109 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 720555006110 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 720555006111 RNAase interaction site [polypeptide binding]; other site 720555006112 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 720555006113 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 720555006114 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 720555006115 Walker A/P-loop; other site 720555006116 ATP binding site [chemical binding]; other site 720555006117 Q-loop/lid; other site 720555006118 ABC transporter signature motif; other site 720555006119 Walker B; other site 720555006120 D-loop; other site 720555006121 H-loop/switch region; other site 720555006122 Predicted transcriptional regulators [Transcription]; Region: COG1725 720555006123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555006124 DNA-binding site [nucleotide binding]; DNA binding site 720555006125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555006126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555006127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 720555006128 dimerization interface [polypeptide binding]; other site 720555006129 acetoacetate decarboxylase; Provisional; Region: PRK02265 720555006130 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 720555006131 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 720555006132 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 720555006133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555006134 H+ Antiporter protein; Region: 2A0121; TIGR00900 720555006135 putative substrate translocation pore; other site 720555006136 YrhK-like protein; Region: YrhK; pfam14145 720555006137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555006138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555006139 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 720555006140 putative dimerization interface [polypeptide binding]; other site 720555006141 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 720555006142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555006143 putative substrate translocation pore; other site 720555006144 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 720555006145 active site 720555006146 catalytic site [active] 720555006147 substrate binding site [chemical binding]; other site 720555006148 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 720555006149 Cytochrome P450; Region: p450; pfam00067 720555006150 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 720555006151 Flavodoxin; Region: Flavodoxin_1; pfam00258 720555006152 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 720555006153 FAD binding pocket [chemical binding]; other site 720555006154 FAD binding motif [chemical binding]; other site 720555006155 catalytic residues [active] 720555006156 NAD binding pocket [chemical binding]; other site 720555006157 phosphate binding motif [ion binding]; other site 720555006158 beta-alpha-beta structure motif; other site 720555006159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555006160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555006161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 720555006162 Methyltransferase domain; Region: Methyltransf_31; pfam13847 720555006163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555006164 S-adenosylmethionine binding site [chemical binding]; other site 720555006165 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 720555006166 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 720555006167 Uncharacterized conserved protein [Function unknown]; Region: COG5609 720555006168 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 720555006169 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 720555006170 catalytic loop [active] 720555006171 iron binding site [ion binding]; other site 720555006172 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 720555006173 4Fe-4S binding domain; Region: Fer4; pfam00037 720555006174 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 720555006175 [4Fe-4S] binding site [ion binding]; other site 720555006176 molybdopterin cofactor binding site; other site 720555006177 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 720555006178 molybdopterin cofactor binding site; other site 720555006179 Uncharacterized conserved protein [Function unknown]; Region: COG2427 720555006180 YrhC-like protein; Region: YrhC; pfam14143 720555006181 cystathionine beta-lyase; Provisional; Region: PRK07671 720555006182 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 720555006183 homodimer interface [polypeptide binding]; other site 720555006184 substrate-cofactor binding pocket; other site 720555006185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555006186 catalytic residue [active] 720555006187 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 720555006188 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 720555006189 dimer interface [polypeptide binding]; other site 720555006190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555006191 catalytic residue [active] 720555006192 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 720555006193 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 720555006194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555006195 S-adenosylmethionine binding site [chemical binding]; other site 720555006196 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 720555006197 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 720555006198 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 720555006199 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 720555006200 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 720555006201 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 720555006202 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 720555006203 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 720555006204 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 720555006205 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 720555006206 ATP-binding site [chemical binding]; other site 720555006207 Sugar specificity; other site 720555006208 Pyrimidine base specificity; other site 720555006209 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 720555006210 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 720555006211 Peptidase family U32; Region: Peptidase_U32; pfam01136 720555006212 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 720555006213 Peptidase family U32; Region: Peptidase_U32; pfam01136 720555006214 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 720555006215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555006216 S-adenosylmethionine binding site [chemical binding]; other site 720555006217 conserved hypothetical protein, YceG family; Region: TIGR00247 720555006218 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 720555006219 dimerization interface [polypeptide binding]; other site 720555006220 hypothetical protein; Provisional; Region: PRK13678 720555006221 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 720555006222 hypothetical protein; Provisional; Region: PRK05473 720555006223 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 720555006224 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 720555006225 motif 1; other site 720555006226 active site 720555006227 motif 2; other site 720555006228 motif 3; other site 720555006229 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 720555006230 DHHA1 domain; Region: DHHA1; pfam02272 720555006231 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 720555006232 Domain of unknown function DUF20; Region: UPF0118; pfam01594 720555006233 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 720555006234 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 720555006235 Walker A/P-loop; other site 720555006236 ATP binding site [chemical binding]; other site 720555006237 Q-loop/lid; other site 720555006238 ABC transporter signature motif; other site 720555006239 Walker B; other site 720555006240 D-loop; other site 720555006241 H-loop/switch region; other site 720555006242 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 720555006243 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 720555006244 substrate binding pocket [chemical binding]; other site 720555006245 membrane-bound complex binding site; other site 720555006246 hinge residues; other site 720555006247 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 720555006248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555006249 dimer interface [polypeptide binding]; other site 720555006250 conserved gate region; other site 720555006251 putative PBP binding loops; other site 720555006252 ABC-ATPase subunit interface; other site 720555006253 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 720555006254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555006255 dimer interface [polypeptide binding]; other site 720555006256 conserved gate region; other site 720555006257 putative PBP binding loops; other site 720555006258 ABC-ATPase subunit interface; other site 720555006259 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 720555006260 PRC-barrel domain; Region: PRC; pfam05239 720555006261 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 720555006262 AAA domain; Region: AAA_30; pfam13604 720555006263 Family description; Region: UvrD_C_2; pfam13538 720555006264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555006265 binding surface 720555006266 TPR motif; other site 720555006267 TPR repeat; Region: TPR_11; pfam13414 720555006268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555006269 binding surface 720555006270 TPR motif; other site 720555006271 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555006272 TPR repeat; Region: TPR_11; pfam13414 720555006273 binding surface 720555006274 TPR motif; other site 720555006275 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 720555006276 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 720555006277 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 720555006278 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 720555006279 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 720555006280 catalytic residue [active] 720555006281 Predicted transcriptional regulator [Transcription]; Region: COG1959 720555006282 Transcriptional regulator; Region: Rrf2; pfam02082 720555006283 recombination factor protein RarA; Reviewed; Region: PRK13342 720555006284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555006285 Walker A motif; other site 720555006286 ATP binding site [chemical binding]; other site 720555006287 Walker B motif; other site 720555006288 arginine finger; other site 720555006289 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 720555006290 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 720555006291 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 720555006292 putative ATP binding site [chemical binding]; other site 720555006293 putative substrate interface [chemical binding]; other site 720555006294 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 720555006295 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 720555006296 dimer interface [polypeptide binding]; other site 720555006297 anticodon binding site; other site 720555006298 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 720555006299 homodimer interface [polypeptide binding]; other site 720555006300 motif 1; other site 720555006301 active site 720555006302 motif 2; other site 720555006303 GAD domain; Region: GAD; pfam02938 720555006304 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 720555006305 motif 3; other site 720555006306 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 720555006307 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 720555006308 dimer interface [polypeptide binding]; other site 720555006309 motif 1; other site 720555006310 active site 720555006311 motif 2; other site 720555006312 motif 3; other site 720555006313 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 720555006314 anticodon binding site; other site 720555006315 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 720555006316 Bacterial SH3 domain homologues; Region: SH3b; smart00287 720555006317 Bacterial SH3 domain; Region: SH3_3; pfam08239 720555006318 Bacterial SH3 domain; Region: SH3_3; pfam08239 720555006319 Bacterial SH3 domain homologues; Region: SH3b; smart00287 720555006320 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 720555006321 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 720555006322 active site 720555006323 metal binding site [ion binding]; metal-binding site 720555006324 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 720555006325 putative active site [active] 720555006326 dimerization interface [polypeptide binding]; other site 720555006327 putative tRNAtyr binding site [nucleotide binding]; other site 720555006328 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 720555006329 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 720555006330 Zn2+ binding site [ion binding]; other site 720555006331 Mg2+ binding site [ion binding]; other site 720555006332 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 720555006333 synthetase active site [active] 720555006334 NTP binding site [chemical binding]; other site 720555006335 metal binding site [ion binding]; metal-binding site 720555006336 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 720555006337 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 720555006338 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 720555006339 active site 720555006340 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 720555006341 DHH family; Region: DHH; pfam01368 720555006342 DHHA1 domain; Region: DHHA1; pfam02272 720555006343 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 720555006344 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 720555006345 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 720555006346 TrkA-C domain; Region: TrkA_C; pfam02080 720555006347 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 720555006348 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 720555006349 Protein export membrane protein; Region: SecD_SecF; pfam02355 720555006350 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 720555006351 stage V sporulation protein B; Region: spore_V_B; TIGR02900 720555006352 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 720555006353 Predicted membrane protein [Function unknown]; Region: COG2323 720555006354 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 720555006355 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 720555006356 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 720555006357 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 720555006358 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 720555006359 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 720555006360 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 720555006361 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 720555006362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555006363 Walker A motif; other site 720555006364 ATP binding site [chemical binding]; other site 720555006365 Walker B motif; other site 720555006366 arginine finger; other site 720555006367 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 720555006368 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 720555006369 RuvA N terminal domain; Region: RuvA_N; pfam01330 720555006370 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 720555006371 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 720555006372 BofC C-terminal domain; Region: BofC_C; pfam08955 720555006373 polyol permease family; Region: 2A0118; TIGR00897 720555006374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555006375 putative substrate translocation pore; other site 720555006376 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 720555006377 active site 720555006378 substrate binding site [chemical binding]; other site 720555006379 ATP binding site [chemical binding]; other site 720555006380 hypothetical protein; Validated; Region: PRK00110 720555006381 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 720555006382 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 720555006383 active site 720555006384 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 720555006385 Chitinase C; Region: ChiC; pfam06483 720555006386 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 720555006387 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 720555006388 active site 720555006389 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 720555006390 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 720555006391 Interdomain contacts; other site 720555006392 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 720555006393 aromatic chitin/cellulose binding site residues [chemical binding]; other site 720555006394 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 720555006395 putative active site [active] 720555006396 YdjC motif; other site 720555006397 Mg binding site [ion binding]; other site 720555006398 putative homodimer interface [polypeptide binding]; other site 720555006399 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 720555006400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555006401 DNA-binding site [nucleotide binding]; DNA binding site 720555006402 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 720555006403 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 720555006404 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 720555006405 NAD binding site [chemical binding]; other site 720555006406 sugar binding site [chemical binding]; other site 720555006407 divalent metal binding site [ion binding]; other site 720555006408 tetramer (dimer of dimers) interface [polypeptide binding]; other site 720555006409 dimer interface [polypeptide binding]; other site 720555006410 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 720555006411 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 720555006412 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 720555006413 methionine cluster; other site 720555006414 active site 720555006415 phosphorylation site [posttranslational modification] 720555006416 metal binding site [ion binding]; metal-binding site 720555006417 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 720555006418 active site 720555006419 P-loop; other site 720555006420 phosphorylation site [posttranslational modification] 720555006421 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 720555006422 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555006423 quinolinate synthetase; Provisional; Region: PRK09375 720555006424 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 720555006425 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 720555006426 dimerization interface [polypeptide binding]; other site 720555006427 active site 720555006428 L-aspartate oxidase; Provisional; Region: PRK08071 720555006429 L-aspartate oxidase; Provisional; Region: PRK06175 720555006430 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 720555006431 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 720555006432 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 720555006433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 720555006434 catalytic residue [active] 720555006435 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 720555006436 HTH domain; Region: HTH_11; pfam08279 720555006437 3H domain; Region: 3H; pfam02829 720555006438 prephenate dehydratase; Provisional; Region: PRK11898 720555006439 Prephenate dehydratase; Region: PDT; pfam00800 720555006440 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 720555006441 putative L-Phe binding site [chemical binding]; other site 720555006442 hypothetical protein; Provisional; Region: PRK04435 720555006443 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 720555006444 GTPase CgtA; Reviewed; Region: obgE; PRK12297 720555006445 GTP1/OBG; Region: GTP1_OBG; pfam01018 720555006446 Obg GTPase; Region: Obg; cd01898 720555006447 G1 box; other site 720555006448 GTP/Mg2+ binding site [chemical binding]; other site 720555006449 Switch I region; other site 720555006450 G2 box; other site 720555006451 G3 box; other site 720555006452 Switch II region; other site 720555006453 G4 box; other site 720555006454 G5 box; other site 720555006455 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 720555006456 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 720555006457 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 720555006458 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 720555006459 hypothetical protein; Provisional; Region: PRK14553 720555006460 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 720555006461 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 720555006462 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 720555006463 Peptidase family M50; Region: Peptidase_M50; pfam02163 720555006464 active site 720555006465 putative substrate binding region [chemical binding]; other site 720555006466 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 720555006467 Peptidase family M23; Region: Peptidase_M23; pfam01551 720555006468 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 720555006469 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 720555006470 Switch I; other site 720555006471 Switch II; other site 720555006472 septum formation inhibitor; Reviewed; Region: minC; PRK00513 720555006473 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 720555006474 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 720555006475 rod shape-determining protein MreC; Region: mreC; TIGR00219 720555006476 rod shape-determining protein MreC; Region: MreC; pfam04085 720555006477 rod shape-determining protein MreB; Provisional; Region: PRK13927 720555006478 MreB and similar proteins; Region: MreB_like; cd10225 720555006479 nucleotide binding site [chemical binding]; other site 720555006480 Mg binding site [ion binding]; other site 720555006481 putative protofilament interaction site [polypeptide binding]; other site 720555006482 RodZ interaction site [polypeptide binding]; other site 720555006483 hypothetical protein; Reviewed; Region: PRK00024 720555006484 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 720555006485 MPN+ (JAMM) motif; other site 720555006486 Zinc-binding site [ion binding]; other site 720555006487 Maf-like protein; Region: Maf; pfam02545 720555006488 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 720555006489 active site 720555006490 dimer interface [polypeptide binding]; other site 720555006491 Sporulation related domain; Region: SPOR; pfam05036 720555006492 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 720555006493 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 720555006494 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 720555006495 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 720555006496 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 720555006497 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 720555006498 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 720555006499 active site 720555006500 HIGH motif; other site 720555006501 nucleotide binding site [chemical binding]; other site 720555006502 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 720555006503 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 720555006504 active site 720555006505 KMSKS motif; other site 720555006506 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 720555006507 tRNA binding surface [nucleotide binding]; other site 720555006508 anticodon binding site; other site 720555006509 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 720555006510 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 720555006511 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 720555006512 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555006513 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 720555006514 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 720555006515 inhibitor-cofactor binding pocket; inhibition site 720555006516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555006517 catalytic residue [active] 720555006518 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 720555006519 dimer interface [polypeptide binding]; other site 720555006520 active site 720555006521 Schiff base residues; other site 720555006522 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 720555006523 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 720555006524 active site 720555006525 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 720555006526 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 720555006527 domain interfaces; other site 720555006528 active site 720555006529 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 720555006530 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 720555006531 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 720555006532 tRNA; other site 720555006533 putative tRNA binding site [nucleotide binding]; other site 720555006534 putative NADP binding site [chemical binding]; other site 720555006535 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 720555006536 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 720555006537 G1 box; other site 720555006538 GTP/Mg2+ binding site [chemical binding]; other site 720555006539 Switch I region; other site 720555006540 G2 box; other site 720555006541 G3 box; other site 720555006542 Switch II region; other site 720555006543 G4 box; other site 720555006544 G5 box; other site 720555006545 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 720555006546 Found in ATP-dependent protease La (LON); Region: LON; smart00464 720555006547 Found in ATP-dependent protease La (LON); Region: LON; smart00464 720555006548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555006549 Walker A motif; other site 720555006550 ATP binding site [chemical binding]; other site 720555006551 Walker B motif; other site 720555006552 arginine finger; other site 720555006553 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 720555006554 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 720555006555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555006556 Walker A motif; other site 720555006557 ATP binding site [chemical binding]; other site 720555006558 Walker B motif; other site 720555006559 arginine finger; other site 720555006560 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 720555006561 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 720555006562 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 720555006563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555006564 Walker A motif; other site 720555006565 ATP binding site [chemical binding]; other site 720555006566 Walker B motif; other site 720555006567 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 720555006568 trigger factor; Provisional; Region: tig; PRK01490 720555006569 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 720555006570 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 720555006571 TPR repeat; Region: TPR_11; pfam13414 720555006572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555006573 binding surface 720555006574 TPR motif; other site 720555006575 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 720555006576 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 720555006577 substrate binding site [chemical binding]; other site 720555006578 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 720555006579 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 720555006580 substrate binding site [chemical binding]; other site 720555006581 ligand binding site [chemical binding]; other site 720555006582 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 720555006583 tartrate dehydrogenase; Region: TTC; TIGR02089 720555006584 2-isopropylmalate synthase; Validated; Region: PRK00915 720555006585 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 720555006586 active site 720555006587 catalytic residues [active] 720555006588 metal binding site [ion binding]; metal-binding site 720555006589 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 720555006590 ketol-acid reductoisomerase; Provisional; Region: PRK05479 720555006591 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 720555006592 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 720555006593 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 720555006594 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 720555006595 putative valine binding site [chemical binding]; other site 720555006596 dimer interface [polypeptide binding]; other site 720555006597 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 720555006598 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 720555006599 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 720555006600 PYR/PP interface [polypeptide binding]; other site 720555006601 dimer interface [polypeptide binding]; other site 720555006602 TPP binding site [chemical binding]; other site 720555006603 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 720555006604 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 720555006605 TPP-binding site [chemical binding]; other site 720555006606 dimer interface [polypeptide binding]; other site 720555006607 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 720555006608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555006609 Coenzyme A binding pocket [chemical binding]; other site 720555006610 Heat induced stress protein YflT; Region: YflT; pfam11181 720555006611 conserved domain; Region: TIGR02271 720555006612 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 720555006613 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 720555006614 active site 720555006615 metal binding site [ion binding]; metal-binding site 720555006616 homotetramer interface [polypeptide binding]; other site 720555006617 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 720555006618 active site 720555006619 dimerization interface [polypeptide binding]; other site 720555006620 ribonuclease PH; Reviewed; Region: rph; PRK00173 720555006621 Ribonuclease PH; Region: RNase_PH_bact; cd11362 720555006622 hexamer interface [polypeptide binding]; other site 720555006623 active site 720555006624 Sporulation and spore germination; Region: Germane; pfam10646 720555006625 Spore germination protein [General function prediction only]; Region: COG5401 720555006626 Sporulation and spore germination; Region: Germane; pfam10646 720555006627 glutamate racemase; Provisional; Region: PRK00865 720555006628 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555006629 MarR family; Region: MarR; pfam01047 720555006630 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 720555006631 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 720555006632 DNA binding residues [nucleotide binding] 720555006633 dimerization interface [polypeptide binding]; other site 720555006634 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 720555006635 active site 720555006636 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 720555006637 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 720555006638 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 720555006639 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 720555006640 L-aspartate oxidase; Provisional; Region: PRK06175 720555006641 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 720555006642 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 720555006643 putative Iron-sulfur protein interface [polypeptide binding]; other site 720555006644 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 720555006645 proximal heme binding site [chemical binding]; other site 720555006646 distal heme binding site [chemical binding]; other site 720555006647 putative dimer interface [polypeptide binding]; other site 720555006648 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 720555006649 aspartate kinase; Reviewed; Region: PRK06635 720555006650 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 720555006651 putative nucleotide binding site [chemical binding]; other site 720555006652 putative catalytic residues [active] 720555006653 putative Mg ion binding site [ion binding]; other site 720555006654 putative aspartate binding site [chemical binding]; other site 720555006655 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 720555006656 putative allosteric regulatory site; other site 720555006657 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 720555006658 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 720555006659 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 720555006660 GIY-YIG motif/motif A; other site 720555006661 active site 720555006662 catalytic site [active] 720555006663 putative DNA binding site [nucleotide binding]; other site 720555006664 metal binding site [ion binding]; metal-binding site 720555006665 UvrB/uvrC motif; Region: UVR; pfam02151 720555006666 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 720555006667 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 720555006668 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 720555006669 catalytic residues [active] 720555006670 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 720555006671 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 720555006672 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 720555006673 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 720555006674 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 720555006675 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 720555006676 Ligand binding site [chemical binding]; other site 720555006677 Electron transfer flavoprotein domain; Region: ETF; pfam01012 720555006678 enoyl-CoA hydratase; Provisional; Region: PRK07658 720555006679 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 720555006680 substrate binding site [chemical binding]; other site 720555006681 oxyanion hole (OAH) forming residues; other site 720555006682 trimer interface [polypeptide binding]; other site 720555006683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555006684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555006685 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 720555006686 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 720555006687 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 720555006688 acyl-activating enzyme (AAE) consensus motif; other site 720555006689 putative AMP binding site [chemical binding]; other site 720555006690 putative active site [active] 720555006691 putative CoA binding site [chemical binding]; other site 720555006692 Predicted membrane protein [Function unknown]; Region: COG3766 720555006693 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 720555006694 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 720555006695 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 720555006696 MutS domain III; Region: MutS_III; pfam05192 720555006697 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 720555006698 Walker A/P-loop; other site 720555006699 ATP binding site [chemical binding]; other site 720555006700 Q-loop/lid; other site 720555006701 ABC transporter signature motif; other site 720555006702 Walker B; other site 720555006703 D-loop; other site 720555006704 H-loop/switch region; other site 720555006705 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 720555006706 Smr domain; Region: Smr; pfam01713 720555006707 hypothetical protein; Provisional; Region: PRK08609 720555006708 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 720555006709 active site 720555006710 primer binding site [nucleotide binding]; other site 720555006711 NTP binding site [chemical binding]; other site 720555006712 metal binding triad [ion binding]; metal-binding site 720555006713 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 720555006714 active site 720555006715 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 720555006716 Colicin V production protein; Region: Colicin_V; pfam02674 720555006717 cell division protein ZapA; Provisional; Region: PRK14126 720555006718 ribonuclease HIII; Provisional; Region: PRK00996 720555006719 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 720555006720 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 720555006721 RNA/DNA hybrid binding site [nucleotide binding]; other site 720555006722 active site 720555006723 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 720555006724 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 720555006725 putative tRNA-binding site [nucleotide binding]; other site 720555006726 B3/4 domain; Region: B3_4; pfam03483 720555006727 tRNA synthetase B5 domain; Region: B5; smart00874 720555006728 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 720555006729 dimer interface [polypeptide binding]; other site 720555006730 motif 1; other site 720555006731 motif 3; other site 720555006732 motif 2; other site 720555006733 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 720555006734 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 720555006735 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 720555006736 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 720555006737 dimer interface [polypeptide binding]; other site 720555006738 motif 1; other site 720555006739 active site 720555006740 motif 2; other site 720555006741 motif 3; other site 720555006742 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 720555006743 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 720555006744 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 720555006745 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 720555006746 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 720555006747 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 720555006748 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 720555006749 FAD binding domain; Region: FAD_binding_4; pfam01565 720555006750 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 720555006751 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 720555006752 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 720555006753 Cysteine-rich domain; Region: CCG; pfam02754 720555006754 Cysteine-rich domain; Region: CCG; pfam02754 720555006755 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 720555006756 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555006757 active site 720555006758 metal binding site [ion binding]; metal-binding site 720555006759 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 720555006760 Carbon starvation protein CstA; Region: CstA; pfam02554 720555006761 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 720555006762 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 720555006763 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 720555006764 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 720555006765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555006766 dimer interface [polypeptide binding]; other site 720555006767 conserved gate region; other site 720555006768 putative PBP binding loops; other site 720555006769 ABC-ATPase subunit interface; other site 720555006770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555006771 dimer interface [polypeptide binding]; other site 720555006772 conserved gate region; other site 720555006773 putative PBP binding loops; other site 720555006774 ABC-ATPase subunit interface; other site 720555006775 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 720555006776 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 720555006777 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 720555006778 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 720555006779 active site 720555006780 metal binding site [ion binding]; metal-binding site 720555006781 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 720555006782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555006783 active site 720555006784 motif I; other site 720555006785 motif II; other site 720555006786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555006787 motif II; other site 720555006788 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 720555006789 L-ribulose-5-phosphate 4-epimerase; Region: araD; TIGR00760 720555006790 intersubunit interface [polypeptide binding]; other site 720555006791 active site 720555006792 Zn2+ binding site [ion binding]; other site 720555006793 ribulokinase; Provisional; Region: PRK04123 720555006794 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 720555006795 N- and C-terminal domain interface [polypeptide binding]; other site 720555006796 active site 720555006797 MgATP binding site [chemical binding]; other site 720555006798 catalytic site [active] 720555006799 metal binding site [ion binding]; metal-binding site 720555006800 carbohydrate binding site [chemical binding]; other site 720555006801 homodimer interface [polypeptide binding]; other site 720555006802 L-arabinose isomerase; Provisional; Region: PRK02929 720555006803 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 720555006804 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 720555006805 trimer interface [polypeptide binding]; other site 720555006806 putative substrate binding site [chemical binding]; other site 720555006807 putative metal binding site [ion binding]; other site 720555006808 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 720555006809 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 720555006810 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 720555006811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555006812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555006813 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 720555006814 substrate binding site [chemical binding]; other site 720555006815 active site 720555006816 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 720555006817 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 720555006818 oligomer interface [polypeptide binding]; other site 720555006819 active site 720555006820 metal binding site [ion binding]; metal-binding site 720555006821 Predicted membrane protein [Function unknown]; Region: COG3326 720555006822 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 720555006823 23S rRNA binding site [nucleotide binding]; other site 720555006824 L21 binding site [polypeptide binding]; other site 720555006825 L13 binding site [polypeptide binding]; other site 720555006826 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 720555006827 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 720555006828 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 720555006829 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 720555006830 antiholin-like protein LrgB; Provisional; Region: PRK04288 720555006831 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 720555006832 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 720555006833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555006834 active site 720555006835 phosphorylation site [posttranslational modification] 720555006836 intermolecular recognition site; other site 720555006837 dimerization interface [polypeptide binding]; other site 720555006838 LytTr DNA-binding domain; Region: LytTR; smart00850 720555006839 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 720555006840 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 720555006841 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 720555006842 Histidine kinase; Region: His_kinase; pfam06580 720555006843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555006844 ATP binding site [chemical binding]; other site 720555006845 Mg2+ binding site [ion binding]; other site 720555006846 G-X-G motif; other site 720555006847 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 720555006848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555006849 motif II; other site 720555006850 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 720555006851 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 720555006852 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 720555006853 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 720555006854 active site 720555006855 dimer interface [polypeptide binding]; other site 720555006856 motif 1; other site 720555006857 motif 2; other site 720555006858 motif 3; other site 720555006859 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 720555006860 anticodon binding site; other site 720555006861 YtxC-like family; Region: YtxC; pfam08812 720555006862 Uncharacterized conserved protein [Function unknown]; Region: COG0398 720555006863 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 720555006864 primosomal protein DnaI; Reviewed; Region: PRK08939 720555006865 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 720555006866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555006867 Walker A motif; other site 720555006868 ATP binding site [chemical binding]; other site 720555006869 Walker B motif; other site 720555006870 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 720555006871 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 720555006872 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 720555006873 ATP cone domain; Region: ATP-cone; pfam03477 720555006874 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 720555006875 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 720555006876 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 720555006877 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 720555006878 Predicted transcriptional regulators [Transcription]; Region: COG1733 720555006879 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 720555006880 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 720555006881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555006882 putative substrate translocation pore; other site 720555006883 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 720555006884 active site 720555006885 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 720555006886 catalytic tetrad [active] 720555006887 dephospho-CoA kinase; Region: TIGR00152 720555006888 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 720555006889 CoA-binding site [chemical binding]; other site 720555006890 ATP-binding [chemical binding]; other site 720555006891 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 720555006892 Domain of unknown function DUF; Region: DUF204; pfam02659 720555006893 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 720555006894 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 720555006895 DNA binding site [nucleotide binding] 720555006896 catalytic residue [active] 720555006897 H2TH interface [polypeptide binding]; other site 720555006898 putative catalytic residues [active] 720555006899 turnover-facilitating residue; other site 720555006900 intercalation triad [nucleotide binding]; other site 720555006901 8OG recognition residue [nucleotide binding]; other site 720555006902 putative reading head residues; other site 720555006903 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 720555006904 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 720555006905 DNA polymerase I; Provisional; Region: PRK05755 720555006906 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 720555006907 active site 720555006908 metal binding site 1 [ion binding]; metal-binding site 720555006909 putative 5' ssDNA interaction site; other site 720555006910 metal binding site 3; metal-binding site 720555006911 metal binding site 2 [ion binding]; metal-binding site 720555006912 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 720555006913 putative DNA binding site [nucleotide binding]; other site 720555006914 putative metal binding site [ion binding]; other site 720555006915 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 720555006916 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 720555006917 active site 720555006918 DNA binding site [nucleotide binding] 720555006919 catalytic site [active] 720555006920 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 720555006921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555006922 putative active site [active] 720555006923 heme pocket [chemical binding]; other site 720555006924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555006925 dimer interface [polypeptide binding]; other site 720555006926 phosphorylation site [posttranslational modification] 720555006927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555006928 ATP binding site [chemical binding]; other site 720555006929 Mg2+ binding site [ion binding]; other site 720555006930 G-X-G motif; other site 720555006931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555006932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555006933 active site 720555006934 phosphorylation site [posttranslational modification] 720555006935 intermolecular recognition site; other site 720555006936 dimerization interface [polypeptide binding]; other site 720555006937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 720555006938 DNA binding site [nucleotide binding] 720555006939 malate dehydrogenase; Reviewed; Region: PRK06223 720555006940 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 720555006941 NAD(P) binding site [chemical binding]; other site 720555006942 dimer interface [polypeptide binding]; other site 720555006943 tetramer (dimer of dimers) interface [polypeptide binding]; other site 720555006944 substrate binding site [chemical binding]; other site 720555006945 isocitrate dehydrogenase; Reviewed; Region: PRK07006 720555006946 isocitrate dehydrogenase; Validated; Region: PRK07362 720555006947 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 720555006948 dimer interface [polypeptide binding]; other site 720555006949 Citrate synthase; Region: Citrate_synt; pfam00285 720555006950 active site 720555006951 citrylCoA binding site [chemical binding]; other site 720555006952 oxalacetate/citrate binding site [chemical binding]; other site 720555006953 coenzyme A binding site [chemical binding]; other site 720555006954 catalytic triad [active] 720555006955 Protein of unknown function (DUF441); Region: DUF441; pfam04284 720555006956 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 720555006957 Domain of unknown function DUF20; Region: UPF0118; pfam01594 720555006958 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 720555006959 pyruvate kinase; Provisional; Region: PRK06354 720555006960 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 720555006961 domain interfaces; other site 720555006962 active site 720555006963 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 720555006964 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 720555006965 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 720555006966 active site 720555006967 ADP/pyrophosphate binding site [chemical binding]; other site 720555006968 dimerization interface [polypeptide binding]; other site 720555006969 allosteric effector site; other site 720555006970 fructose-1,6-bisphosphate binding site; other site 720555006971 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 720555006972 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 720555006973 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 720555006974 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 720555006975 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 720555006976 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 720555006977 Malic enzyme, N-terminal domain; Region: malic; pfam00390 720555006978 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 720555006979 putative NAD(P) binding site [chemical binding]; other site 720555006980 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 720555006981 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 720555006982 active site 720555006983 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 720555006984 generic binding surface II; other site 720555006985 generic binding surface I; other site 720555006986 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 720555006987 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 720555006988 DHH family; Region: DHH; pfam01368 720555006989 DHHA1 domain; Region: DHHA1; pfam02272 720555006990 YtpI-like protein; Region: YtpI; pfam14007 720555006991 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 720555006992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555006993 DNA-binding site [nucleotide binding]; DNA binding site 720555006994 DRTGG domain; Region: DRTGG; pfam07085 720555006995 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 720555006996 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 720555006997 active site 2 [active] 720555006998 active site 1 [active] 720555006999 metal-dependent hydrolase; Provisional; Region: PRK00685 720555007000 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 720555007001 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 720555007002 classical (c) SDRs; Region: SDR_c; cd05233 720555007003 NAD(P) binding site [chemical binding]; other site 720555007004 active site 720555007005 argininosuccinate lyase; Provisional; Region: PRK00855 720555007006 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 720555007007 active sites [active] 720555007008 tetramer interface [polypeptide binding]; other site 720555007009 argininosuccinate synthase; Provisional; Region: PRK13820 720555007010 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 720555007011 ANP binding site [chemical binding]; other site 720555007012 Substrate Binding Site II [chemical binding]; other site 720555007013 Substrate Binding Site I [chemical binding]; other site 720555007014 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 720555007015 MPT binding site; other site 720555007016 trimer interface [polypeptide binding]; other site 720555007017 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 720555007018 propionate/acetate kinase; Provisional; Region: PRK12379 720555007019 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 720555007020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555007021 S-adenosylmethionine binding site [chemical binding]; other site 720555007022 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 720555007023 dimer interface [polypeptide binding]; other site 720555007024 catalytic triad [active] 720555007025 peroxidatic and resolving cysteines [active] 720555007026 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 720555007027 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 720555007028 RDD family; Region: RDD; pfam06271 720555007029 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 720555007030 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 720555007031 tandem repeat interface [polypeptide binding]; other site 720555007032 oligomer interface [polypeptide binding]; other site 720555007033 active site residues [active] 720555007034 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 720555007035 ATP-NAD kinase; Region: NAD_kinase; pfam01513 720555007036 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 720555007037 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 720555007038 active site 720555007039 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 720555007040 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 720555007041 active site 720555007042 acyl-activating enzyme (AAE) consensus motif; other site 720555007043 putative CoA binding site [chemical binding]; other site 720555007044 AMP binding site [chemical binding]; other site 720555007045 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 720555007046 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 720555007047 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 720555007048 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 720555007049 Ligand Binding Site [chemical binding]; other site 720555007050 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 720555007051 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 720555007052 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 720555007053 catalytic residue [active] 720555007054 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 720555007055 septation ring formation regulator EzrA; Provisional; Region: PRK04778 720555007056 TMPIT-like protein; Region: TMPIT; pfam07851 720555007057 histidinol-phosphatase; Reviewed; Region: PRK08123 720555007058 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 720555007059 active site 720555007060 dimer interface [polypeptide binding]; other site 720555007061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555007062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555007063 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 720555007064 GAF domain; Region: GAF_2; pfam13185 720555007065 GAF domain; Region: GAF_2; pfam13185 720555007066 GAF domain; Region: GAF; cl17456 720555007067 GAF domain; Region: GAF_3; pfam13492 720555007068 GAF domain; Region: GAF_2; pfam13185 720555007069 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 720555007070 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 720555007071 metal binding site [ion binding]; metal-binding site 720555007072 active site 720555007073 I-site; other site 720555007074 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 720555007075 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 720555007076 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 720555007077 RNA binding surface [nucleotide binding]; other site 720555007078 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 720555007079 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 720555007080 TAP-like protein; Region: Abhydrolase_4; pfam08386 720555007081 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 720555007082 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 720555007083 active site 720555007084 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 720555007085 Isochorismatase family; Region: Isochorismatase; pfam00857 720555007086 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 720555007087 catalytic triad [active] 720555007088 dimer interface [polypeptide binding]; other site 720555007089 conserved cis-peptide bond; other site 720555007090 potential frameshift: common BLAST hit: gi|295705760|ref|YP_003598835.1| NADPH-dependent FMN reductase 720555007091 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555007092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555007093 putative DNA binding site [nucleotide binding]; other site 720555007094 putative Zn2+ binding site [ion binding]; other site 720555007095 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555007096 MarR family; Region: MarR; pfam01047 720555007097 MarR family; Region: MarR_2; cl17246 720555007098 Predicted membrane protein [Function unknown]; Region: COG2259 720555007099 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 720555007100 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555007101 Zn binding site [ion binding]; other site 720555007102 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 720555007103 Zn binding site [ion binding]; other site 720555007104 Predicted esterase [General function prediction only]; Region: COG0400 720555007105 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 720555007106 EamA-like transporter family; Region: EamA; pfam00892 720555007107 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555007108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555007109 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 720555007110 putative dimerization interface [polypeptide binding]; other site 720555007111 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 720555007112 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 720555007113 active site 720555007114 HIGH motif; other site 720555007115 dimer interface [polypeptide binding]; other site 720555007116 KMSKS motif; other site 720555007117 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 720555007118 RNA binding surface [nucleotide binding]; other site 720555007119 acetyl-CoA synthetase; Provisional; Region: PRK04319 720555007120 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 720555007121 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 720555007122 active site 720555007123 acyl-activating enzyme (AAE) consensus motif; other site 720555007124 putative CoA binding site [chemical binding]; other site 720555007125 AMP binding site [chemical binding]; other site 720555007126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555007127 Coenzyme A binding pocket [chemical binding]; other site 720555007128 FOG: CBS domain [General function prediction only]; Region: COG0517 720555007129 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 720555007130 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 720555007131 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 720555007132 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 720555007133 active site 720555007134 Zn binding site [ion binding]; other site 720555007135 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 720555007136 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 720555007137 ligand binding site [chemical binding]; other site 720555007138 flagellar motor protein MotP; Reviewed; Region: PRK06926 720555007139 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 720555007140 catabolite control protein A; Region: ccpA; TIGR01481 720555007141 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 720555007142 DNA binding site [nucleotide binding] 720555007143 domain linker motif; other site 720555007144 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 720555007145 dimerization interface [polypeptide binding]; other site 720555007146 effector binding site; other site 720555007147 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 720555007148 chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801 720555007149 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 720555007150 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 720555007151 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 720555007152 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 720555007153 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 720555007154 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 720555007155 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 720555007156 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 720555007157 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 720555007158 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 720555007159 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 720555007160 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 720555007161 putative tRNA-binding site [nucleotide binding]; other site 720555007162 hypothetical protein; Provisional; Region: PRK13668 720555007163 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 720555007164 catalytic residues [active] 720555007165 YtoQ family protein; Region: YtoQ_fam; TIGR03646 720555007166 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 720555007167 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 720555007168 oligomer interface [polypeptide binding]; other site 720555007169 active site 720555007170 metal binding site [ion binding]; metal-binding site 720555007171 Predicted small secreted protein [Function unknown]; Region: COG5584 720555007172 malate dehydrogenase; Provisional; Region: PRK13529 720555007173 Malic enzyme, N-terminal domain; Region: malic; pfam00390 720555007174 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 720555007175 NAD(P) binding site [chemical binding]; other site 720555007176 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 720555007177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555007178 S-adenosylmethionine binding site [chemical binding]; other site 720555007179 YtzH-like protein; Region: YtzH; pfam14165 720555007180 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 720555007181 active site 720555007182 ATP binding site [chemical binding]; other site 720555007183 Phosphotransferase enzyme family; Region: APH; pfam01636 720555007184 substrate binding site [chemical binding]; other site 720555007185 pullulanase, type I; Region: pulA_typeI; TIGR02104 720555007186 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 720555007187 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 720555007188 Ca binding site [ion binding]; other site 720555007189 active site 720555007190 catalytic site [active] 720555007191 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 720555007192 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 720555007193 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 720555007194 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 720555007195 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 720555007196 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 720555007197 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 720555007198 dimer interface [polypeptide binding]; other site 720555007199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555007200 catalytic residue [active] 720555007201 dipeptidase PepV; Reviewed; Region: PRK07318 720555007202 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 720555007203 active site 720555007204 metal binding site [ion binding]; metal-binding site 720555007205 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 720555007206 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 720555007207 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 720555007208 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 720555007209 RNA binding surface [nucleotide binding]; other site 720555007210 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 720555007211 active site 720555007212 uracil binding [chemical binding]; other site 720555007213 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 720555007214 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 720555007215 HI0933-like protein; Region: HI0933_like; pfam03486 720555007216 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 720555007217 BCCT family transporter; Region: BCCT; pfam02028 720555007218 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 720555007219 Predicted integral membrane protein [Function unknown]; Region: COG5578 720555007220 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 720555007221 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 720555007222 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 720555007223 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 720555007224 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 720555007225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555007226 dimer interface [polypeptide binding]; other site 720555007227 conserved gate region; other site 720555007228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 720555007229 ABC-ATPase subunit interface; other site 720555007230 potential frameshift: common BLAST hit: gi|305675595|ref|YP_003867267.1| putative membrane bound transcriptional regulator (AraC/XylS 720555007231 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 720555007232 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 720555007233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555007234 dimer interface [polypeptide binding]; other site 720555007235 conserved gate region; other site 720555007236 putative PBP binding loops; other site 720555007237 ABC-ATPase subunit interface; other site 720555007238 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 720555007239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555007240 NAD(P) binding site [chemical binding]; other site 720555007241 active site 720555007242 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 720555007243 Cytochrome P450; Region: p450; cl12078 720555007244 biotin synthase; Validated; Region: PRK06256 720555007245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 720555007246 FeS/SAM binding site; other site 720555007247 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 720555007248 AAA domain; Region: AAA_26; pfam13500 720555007249 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 720555007250 ADP binding site [chemical binding]; other site 720555007251 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 720555007252 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 720555007253 substrate-cofactor binding pocket; other site 720555007254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555007255 catalytic residue [active] 720555007256 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 720555007257 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 720555007258 inhibitor-cofactor binding pocket; inhibition site 720555007259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555007260 catalytic residue [active] 720555007261 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 720555007262 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 720555007263 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 720555007264 active site residue [active] 720555007265 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 720555007266 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 720555007267 HIGH motif; other site 720555007268 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 720555007269 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 720555007270 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 720555007271 active site 720555007272 KMSKS motif; other site 720555007273 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 720555007274 tRNA binding surface [nucleotide binding]; other site 720555007275 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 720555007276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555007277 PAS domain; Region: PAS_9; pfam13426 720555007278 putative active site [active] 720555007279 heme pocket [chemical binding]; other site 720555007280 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 720555007281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555007282 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555007283 putative substrate translocation pore; other site 720555007284 FtsX-like permease family; Region: FtsX; pfam02687 720555007285 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 720555007286 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 720555007287 Walker A/P-loop; other site 720555007288 ATP binding site [chemical binding]; other site 720555007289 Q-loop/lid; other site 720555007290 ABC transporter signature motif; other site 720555007291 Walker B; other site 720555007292 D-loop; other site 720555007293 H-loop/switch region; other site 720555007294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 720555007295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555007296 ATP binding site [chemical binding]; other site 720555007297 Mg2+ binding site [ion binding]; other site 720555007298 G-X-G motif; other site 720555007299 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555007300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555007301 active site 720555007302 phosphorylation site [posttranslational modification] 720555007303 intermolecular recognition site; other site 720555007304 dimerization interface [polypeptide binding]; other site 720555007305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 720555007306 DNA binding site [nucleotide binding] 720555007307 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 720555007308 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 720555007309 FtsX-like permease family; Region: FtsX; pfam02687 720555007310 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 720555007311 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 720555007312 Walker A/P-loop; other site 720555007313 ATP binding site [chemical binding]; other site 720555007314 Q-loop/lid; other site 720555007315 ABC transporter signature motif; other site 720555007316 Walker B; other site 720555007317 D-loop; other site 720555007318 H-loop/switch region; other site 720555007319 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 720555007320 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 720555007321 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 720555007322 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 720555007323 Walker A/P-loop; other site 720555007324 ATP binding site [chemical binding]; other site 720555007325 Q-loop/lid; other site 720555007326 ABC transporter signature motif; other site 720555007327 Walker B; other site 720555007328 D-loop; other site 720555007329 H-loop/switch region; other site 720555007330 Predicted transcriptional regulators [Transcription]; Region: COG1725 720555007331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555007332 DNA-binding site [nucleotide binding]; DNA binding site 720555007333 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 720555007334 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555007335 dimerization interface [polypeptide binding]; other site 720555007336 putative DNA binding site [nucleotide binding]; other site 720555007337 putative Zn2+ binding site [ion binding]; other site 720555007338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555007339 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555007340 putative substrate translocation pore; other site 720555007341 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 720555007342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555007343 S-adenosylmethionine binding site [chemical binding]; other site 720555007344 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 720555007345 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 720555007346 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 720555007347 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 720555007348 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 720555007349 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 720555007350 trimer interface [polypeptide binding]; other site 720555007351 putative metal binding site [ion binding]; other site 720555007352 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 720555007353 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 720555007354 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 720555007355 active site 720555007356 dimer interface [polypeptide binding]; other site 720555007357 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 720555007358 Ligand Binding Site [chemical binding]; other site 720555007359 Molecular Tunnel; other site 720555007360 S-adenosylmethionine synthetase; Validated; Region: PRK05250 720555007361 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 720555007362 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 720555007363 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 720555007364 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 720555007365 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 720555007366 active site 720555007367 substrate-binding site [chemical binding]; other site 720555007368 metal-binding site [ion binding] 720555007369 ATP binding site [chemical binding]; other site 720555007370 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 720555007371 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 720555007372 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 720555007373 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 720555007374 NMT1-like family; Region: NMT1_2; pfam13379 720555007375 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 720555007376 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 720555007377 Walker A/P-loop; other site 720555007378 ATP binding site [chemical binding]; other site 720555007379 Q-loop/lid; other site 720555007380 ABC transporter signature motif; other site 720555007381 Walker B; other site 720555007382 D-loop; other site 720555007383 H-loop/switch region; other site 720555007384 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 720555007385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555007386 dimer interface [polypeptide binding]; other site 720555007387 conserved gate region; other site 720555007388 putative PBP binding loops; other site 720555007389 ABC-ATPase subunit interface; other site 720555007390 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 720555007391 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 720555007392 nudix motif; other site 720555007393 Holin family; Region: Phage_holin_4; cl01989 720555007394 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 720555007395 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 720555007396 dimerization interface [polypeptide binding]; other site 720555007397 DPS ferroxidase diiron center [ion binding]; other site 720555007398 ion pore; other site 720555007399 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 720555007400 YtkA-like; Region: YtkA; pfam13115 720555007401 S-ribosylhomocysteinase; Provisional; Region: PRK02260 720555007402 Haemolytic domain; Region: Haemolytic; pfam01809 720555007403 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 720555007404 active site clefts [active] 720555007405 zinc binding site [ion binding]; other site 720555007406 dimer interface [polypeptide binding]; other site 720555007407 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 720555007408 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 720555007409 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 720555007410 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 720555007411 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 720555007412 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 720555007413 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 720555007414 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 720555007415 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 720555007416 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 720555007417 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555007418 ABC-ATPase subunit interface; other site 720555007419 dimer interface [polypeptide binding]; other site 720555007420 putative PBP binding regions; other site 720555007421 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 720555007422 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555007423 ABC-ATPase subunit interface; other site 720555007424 dimer interface [polypeptide binding]; other site 720555007425 putative PBP binding regions; other site 720555007426 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 720555007427 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 720555007428 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 720555007429 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 720555007430 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 720555007431 intersubunit interface [polypeptide binding]; other site 720555007432 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 720555007433 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 720555007434 active site 720555007435 octamer interface [polypeptide binding]; other site 720555007436 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 720555007437 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 720555007438 acyl-activating enzyme (AAE) consensus motif; other site 720555007439 putative AMP binding site [chemical binding]; other site 720555007440 putative active site [active] 720555007441 putative CoA binding site [chemical binding]; other site 720555007442 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 720555007443 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 720555007444 substrate binding site [chemical binding]; other site 720555007445 oxyanion hole (OAH) forming residues; other site 720555007446 trimer interface [polypeptide binding]; other site 720555007447 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 720555007448 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 720555007449 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 720555007450 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 720555007451 dimer interface [polypeptide binding]; other site 720555007452 tetramer interface [polypeptide binding]; other site 720555007453 PYR/PP interface [polypeptide binding]; other site 720555007454 TPP binding site [chemical binding]; other site 720555007455 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 720555007456 TPP-binding site; other site 720555007457 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 720555007458 isochorismate synthases; Region: isochor_syn; TIGR00543 720555007459 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 720555007460 potential frameshift: common BLAST hit: gi|305675670|ref|YP_003867342.1| putative UDP-glucose 6-dehydrogenase ytcA 720555007461 potential frameshift: common BLAST hit: gi|305675670|ref|YP_003867342.1| putative UDP-glucose 6-dehydrogenase ytcA 720555007462 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 720555007463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555007464 NAD(P) binding site [chemical binding]; other site 720555007465 active site 720555007466 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 720555007467 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 720555007468 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 720555007469 TspO/MBR family; Region: TspO_MBR; cl01379 720555007470 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 720555007471 homodimer interface [polypeptide binding]; other site 720555007472 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 720555007473 active site pocket [active] 720555007474 glycogen synthase; Provisional; Region: glgA; PRK00654 720555007475 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 720555007476 ADP-binding pocket [chemical binding]; other site 720555007477 homodimer interface [polypeptide binding]; other site 720555007478 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 720555007479 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 720555007480 ligand binding site; other site 720555007481 oligomer interface; other site 720555007482 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 720555007483 dimer interface [polypeptide binding]; other site 720555007484 N-terminal domain interface [polypeptide binding]; other site 720555007485 sulfate 1 binding site; other site 720555007486 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 720555007487 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 720555007488 ligand binding site; other site 720555007489 oligomer interface; other site 720555007490 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 720555007491 dimer interface [polypeptide binding]; other site 720555007492 N-terminal domain interface [polypeptide binding]; other site 720555007493 sulfate 1 binding site; other site 720555007494 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 720555007495 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 720555007496 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 720555007497 active site 720555007498 catalytic site [active] 720555007499 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 720555007500 potential protein location (hypothetical protein BATR1942_13300 [Bacillus atrophaeus 1942]) that overlaps RNA (tRNA-M) 720555007501 Predicted membrane protein [Function unknown]; Region: COG3859 720555007502 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 720555007503 active site 720555007504 catalytic site [active] 720555007505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 720555007506 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 720555007507 DinB superfamily; Region: DinB_2; pfam12867 720555007508 metal-dependent hydrolase; Provisional; Region: PRK13291 720555007509 MOSC domain; Region: MOSC; pfam03473 720555007510 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 720555007511 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 720555007512 active site 720555007513 NAD binding site [chemical binding]; other site 720555007514 metal binding site [ion binding]; metal-binding site 720555007515 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 720555007516 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 720555007517 tetramerization interface [polypeptide binding]; other site 720555007518 NAD(P) binding site [chemical binding]; other site 720555007519 catalytic residues [active] 720555007520 Predicted transcriptional regulators [Transcription]; Region: COG1510 720555007521 MarR family; Region: MarR_2; pfam12802 720555007522 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 720555007523 TrkA-N domain; Region: TrkA_N; pfam02254 720555007524 TrkA-C domain; Region: TrkA_C; pfam02080 720555007525 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 720555007526 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 720555007527 yiaA/B two helix domain; Region: YiaAB; pfam05360 720555007528 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 720555007529 SH3-like domain; Region: SH3_8; pfam13457 720555007530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555007531 putative substrate translocation pore; other site 720555007532 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 720555007533 potential protein location (hypothetical protein BATR1942_13385 [Bacillus atrophaeus 1942]) that overlaps RNA (tRNA-A) 720555007534 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 720555007535 Domain of unknown function DUF20; Region: UPF0118; pfam01594 720555007536 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 720555007537 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 720555007538 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 720555007539 intracellular protease, PfpI family; Region: PfpI; TIGR01382 720555007540 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 720555007541 proposed catalytic triad [active] 720555007542 conserved cys residue [active] 720555007543 L-rhamnose isomerase; Provisional; Region: PRK01076 720555007544 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 720555007545 Domain of unknown function (DUF718); Region: DUF718; cl01281 720555007546 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 720555007547 N- and C-terminal domain interface [polypeptide binding]; other site 720555007548 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 720555007549 active site 720555007550 putative catalytic site [active] 720555007551 metal binding site [ion binding]; metal-binding site 720555007552 ATP binding site [chemical binding]; other site 720555007553 carbohydrate binding site [chemical binding]; other site 720555007554 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 720555007555 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 720555007556 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 720555007557 short chain dehydrogenase; Validated; Region: PRK08324 720555007558 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 720555007559 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 720555007560 putative NAD(P) binding site [chemical binding]; other site 720555007561 active site 720555007562 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 720555007563 Cache domain; Region: Cache_1; pfam02743 720555007564 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 720555007565 dimerization interface [polypeptide binding]; other site 720555007566 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 720555007567 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 720555007568 dimer interface [polypeptide binding]; other site 720555007569 putative CheW interface [polypeptide binding]; other site 720555007570 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 720555007571 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 720555007572 Cache domain; Region: Cache_1; pfam02743 720555007573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 720555007574 dimerization interface [polypeptide binding]; other site 720555007575 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 720555007576 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 720555007577 dimer interface [polypeptide binding]; other site 720555007578 putative CheW interface [polypeptide binding]; other site 720555007579 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 720555007580 Tar ligand binding domain homologue; Region: TarH; pfam02203 720555007581 Cache domain; Region: Cache_1; pfam02743 720555007582 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 720555007583 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 720555007584 dimerization interface [polypeptide binding]; other site 720555007585 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 720555007586 dimer interface [polypeptide binding]; other site 720555007587 putative CheW interface [polypeptide binding]; other site 720555007588 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 720555007589 Cache domain; Region: Cache_1; pfam02743 720555007590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 720555007591 dimerization interface [polypeptide binding]; other site 720555007592 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 720555007593 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 720555007594 dimer interface [polypeptide binding]; other site 720555007595 putative CheW interface [polypeptide binding]; other site 720555007596 transglutaminase; Provisional; Region: tgl; PRK03187 720555007597 Nitronate monooxygenase; Region: NMO; pfam03060 720555007598 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 720555007599 FMN binding site [chemical binding]; other site 720555007600 substrate binding site [chemical binding]; other site 720555007601 putative catalytic residue [active] 720555007602 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 720555007603 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 720555007604 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 720555007605 Ca binding site [ion binding]; other site 720555007606 active site 720555007607 catalytic site [active] 720555007608 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 720555007609 Domain of unknown function DUF21; Region: DUF21; pfam01595 720555007610 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 720555007611 Transporter associated domain; Region: CorC_HlyC; smart01091 720555007612 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 720555007613 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 720555007614 Ion channel; Region: Ion_trans_2; pfam07885 720555007615 TrkA-N domain; Region: TrkA_N; pfam02254 720555007616 YugN-like family; Region: YugN; pfam08868 720555007617 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 720555007618 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 720555007619 active site 720555007620 dimer interface [polypeptide binding]; other site 720555007621 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 720555007622 dimer interface [polypeptide binding]; other site 720555007623 active site 720555007624 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 720555007625 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 720555007626 dimer interface [polypeptide binding]; other site 720555007627 active site 720555007628 metal binding site [ion binding]; metal-binding site 720555007629 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 720555007630 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 720555007631 dimer interface [polypeptide binding]; other site 720555007632 active site 720555007633 metal binding site [ion binding]; metal-binding site 720555007634 Uncharacterized conserved protein [Function unknown]; Region: COG2155 720555007635 general stress protein 13; Validated; Region: PRK08059 720555007636 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 720555007637 RNA binding site [nucleotide binding]; other site 720555007638 hypothetical protein; Validated; Region: PRK07682 720555007639 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555007640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555007641 homodimer interface [polypeptide binding]; other site 720555007642 catalytic residue [active] 720555007643 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 720555007644 AsnC family; Region: AsnC_trans_reg; pfam01037 720555007645 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 720555007646 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 720555007647 nucleophilic elbow; other site 720555007648 catalytic triad; other site 720555007649 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 720555007650 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 720555007651 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555007652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555007653 homodimer interface [polypeptide binding]; other site 720555007654 catalytic residue [active] 720555007655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 720555007656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555007657 dimer interface [polypeptide binding]; other site 720555007658 phosphorylation site [posttranslational modification] 720555007659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555007660 ATP binding site [chemical binding]; other site 720555007661 Mg2+ binding site [ion binding]; other site 720555007662 G-X-G motif; other site 720555007663 Kinase associated protein B; Region: KapB; pfam08810 720555007664 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 720555007665 active site 720555007666 catalytic site [active] 720555007667 substrate binding site [chemical binding]; other site 720555007668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555007669 putative substrate translocation pore; other site 720555007670 Transglycosylase; Region: Transgly; pfam00912 720555007671 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 720555007672 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 720555007673 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 720555007674 sensory histidine kinase DcuS; Provisional; Region: PRK11086 720555007675 PAS domain; Region: PAS; smart00091 720555007676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555007677 ATP binding site [chemical binding]; other site 720555007678 Mg2+ binding site [ion binding]; other site 720555007679 G-X-G motif; other site 720555007680 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 720555007681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555007682 active site 720555007683 phosphorylation site [posttranslational modification] 720555007684 intermolecular recognition site; other site 720555007685 dimerization interface [polypeptide binding]; other site 720555007686 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 720555007687 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 720555007688 ligand binding site [chemical binding]; other site 720555007689 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 720555007690 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 720555007691 Walker A/P-loop; other site 720555007692 ATP binding site [chemical binding]; other site 720555007693 Q-loop/lid; other site 720555007694 ABC transporter signature motif; other site 720555007695 Walker B; other site 720555007696 D-loop; other site 720555007697 H-loop/switch region; other site 720555007698 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 720555007699 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 720555007700 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 720555007701 TM-ABC transporter signature motif; other site 720555007702 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 720555007703 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 720555007704 TM-ABC transporter signature motif; other site 720555007705 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 720555007706 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 720555007707 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 720555007708 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 720555007709 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 720555007710 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 720555007711 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 720555007712 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 720555007713 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 720555007714 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 720555007715 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 720555007716 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 720555007717 CoenzymeA binding site [chemical binding]; other site 720555007718 subunit interaction site [polypeptide binding]; other site 720555007719 PHB binding site; other site 720555007720 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 720555007721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555007722 active site 720555007723 phosphorylation site [posttranslational modification] 720555007724 intermolecular recognition site; other site 720555007725 dimerization interface [polypeptide binding]; other site 720555007726 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 720555007727 DNA binding residues [nucleotide binding] 720555007728 dimerization interface [polypeptide binding]; other site 720555007729 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 720555007730 Protein of unknown function (DUF2704); Region: DUF2704; pfam10866 720555007731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 720555007732 Histidine kinase; Region: HisKA_3; pfam07730 720555007733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555007734 ATP binding site [chemical binding]; other site 720555007735 Mg2+ binding site [ion binding]; other site 720555007736 G-X-G motif; other site 720555007737 Bacillus competence pheromone ComX; Region: ComX; pfam05952 720555007738 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 720555007739 substrate binding pocket [chemical binding]; other site 720555007740 substrate-Mg2+ binding site; other site 720555007741 aspartate-rich region 1; other site 720555007742 DegQ (SacQ) family; Region: DegQ; pfam08181 720555007743 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 720555007744 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 720555007745 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 720555007746 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 720555007747 active site 720555007748 Isochorismatase family; Region: Isochorismatase; pfam00857 720555007749 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 720555007750 catalytic triad [active] 720555007751 conserved cis-peptide bond; other site 720555007752 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 720555007753 YueH-like protein; Region: YueH; pfam14166 720555007754 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 720555007755 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 720555007756 Domain of unknown function DUF20; Region: UPF0118; pfam01594 720555007757 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 720555007758 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 720555007759 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 720555007760 Zn2+ binding site [ion binding]; other site 720555007761 Mg2+ binding site [ion binding]; other site 720555007762 short chain dehydrogenase; Provisional; Region: PRK06924 720555007763 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 720555007764 NADP binding site [chemical binding]; other site 720555007765 homodimer interface [polypeptide binding]; other site 720555007766 active site 720555007767 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 720555007768 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 720555007769 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 720555007770 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 720555007771 CodY GAF-like domain; Region: CodY; pfam06018 720555007772 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 720555007773 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 720555007774 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 720555007775 hexamer interface [polypeptide binding]; other site 720555007776 ligand binding site [chemical binding]; other site 720555007777 putative active site [active] 720555007778 NAD(P) binding site [chemical binding]; other site 720555007779 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 720555007780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 720555007781 Condensation domain; Region: Condensation; pfam00668 720555007782 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555007783 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 720555007784 acyl-activating enzyme (AAE) consensus motif; other site 720555007785 AMP binding site [chemical binding]; other site 720555007786 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555007787 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 720555007788 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555007789 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555007790 acyl-activating enzyme (AAE) consensus motif; other site 720555007791 AMP binding site [chemical binding]; other site 720555007792 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555007793 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 720555007794 hydrophobic substrate binding pocket; other site 720555007795 Isochorismatase family; Region: Isochorismatase; pfam00857 720555007796 active site 720555007797 conserved cis-peptide bond; other site 720555007798 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 720555007799 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 720555007800 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 720555007801 acyl-activating enzyme (AAE) consensus motif; other site 720555007802 active site 720555007803 AMP binding site [chemical binding]; other site 720555007804 substrate binding site [chemical binding]; other site 720555007805 isochorismate synthase DhbC; Validated; Region: PRK06923 720555007806 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 720555007807 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 720555007808 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 720555007809 putative NAD(P) binding site [chemical binding]; other site 720555007810 active site 720555007811 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 720555007812 Putative esterase; Region: Esterase; pfam00756 720555007813 Regulatory protein YrvL; Region: YrvL; pfam14184 720555007814 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 720555007815 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 720555007816 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 720555007817 Moco binding site; other site 720555007818 metal coordination site [ion binding]; other site 720555007819 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 720555007820 Predicted permease [General function prediction only]; Region: COG2056 720555007821 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 720555007822 multifunctional aminopeptidase A; Provisional; Region: PRK00913 720555007823 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 720555007824 interface (dimer of trimers) [polypeptide binding]; other site 720555007825 Substrate-binding/catalytic site; other site 720555007826 Zn-binding sites [ion binding]; other site 720555007827 Divergent PAP2 family; Region: DUF212; pfam02681 720555007828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 720555007829 Putative membrane protein; Region: YuiB; pfam14068 720555007830 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 720555007831 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 720555007832 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555007833 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 720555007834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 720555007835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555007836 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 720555007837 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 720555007838 active site 720555007839 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 720555007840 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 720555007841 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 720555007842 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 720555007843 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 720555007844 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 720555007845 Nucleoside recognition; Region: Gate; pfam07670 720555007846 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 720555007847 hypothetical protein; Provisional; Region: PRK13669 720555007848 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 720555007849 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555007850 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 720555007851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 720555007852 NifU-like domain; Region: NifU; pfam01106 720555007853 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 720555007854 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 720555007855 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 720555007856 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 720555007857 homoserine kinase; Region: thrB; TIGR00191 720555007858 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 720555007859 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 720555007860 threonine synthase; Reviewed; Region: PRK06721 720555007861 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 720555007862 homodimer interface [polypeptide binding]; other site 720555007863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555007864 catalytic residue [active] 720555007865 homoserine dehydrogenase; Provisional; Region: PRK06349 720555007866 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 720555007867 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 720555007868 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 720555007869 spore coat protein YutH; Region: spore_yutH; TIGR02905 720555007870 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 720555007871 tetramer interfaces [polypeptide binding]; other site 720555007872 binuclear metal-binding site [ion binding]; other site 720555007873 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 720555007874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555007875 active site 720555007876 motif I; other site 720555007877 motif II; other site 720555007878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555007879 Uncharacterized conserved protein [Function unknown]; Region: COG2445 720555007880 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 720555007881 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 720555007882 lipoyl synthase; Provisional; Region: PRK05481 720555007883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 720555007884 FeS/SAM binding site; other site 720555007885 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 720555007886 Peptidase family M23; Region: Peptidase_M23; pfam01551 720555007887 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 720555007888 Uncharacterized conserved protein [Function unknown]; Region: COG3377 720555007889 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 720555007890 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 720555007891 active site 720555007892 metal binding site [ion binding]; metal-binding site 720555007893 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 720555007894 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 720555007895 Uncharacterized conserved protein [Function unknown]; Region: COG1801 720555007896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555007897 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555007898 putative substrate translocation pore; other site 720555007899 allantoinase; Provisional; Region: PRK06189 720555007900 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 720555007901 active site 720555007902 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 720555007903 DRTGG domain; Region: DRTGG; pfam07085 720555007904 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 720555007905 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 720555007906 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 720555007907 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 720555007908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555007909 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555007910 DNA binding residues [nucleotide binding] 720555007911 SpaB C-terminal domain; Region: SpaB_C; pfam14028 720555007912 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 720555007913 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 720555007914 active site 720555007915 putative substrate binding region [chemical binding]; other site 720555007916 FMN binding site [chemical binding]; other site 720555007917 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 720555007918 dimer interface [polypeptide binding]; other site 720555007919 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 720555007920 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 720555007921 NADPH bind site [chemical binding]; other site 720555007922 putative FMN binding site [chemical binding]; other site 720555007923 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 720555007924 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 720555007925 YcaO-like family; Region: YcaO; pfam02624 720555007926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 720555007927 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555007928 DNA binding site [nucleotide binding] 720555007929 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 720555007930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555007931 Walker A/P-loop; other site 720555007932 ATP binding site [chemical binding]; other site 720555007933 Q-loop/lid; other site 720555007934 ABC transporter signature motif; other site 720555007935 Walker B; other site 720555007936 D-loop; other site 720555007937 H-loop/switch region; other site 720555007938 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 720555007939 ABC-2 type transporter; Region: ABC2_membrane; cl17235 720555007940 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 720555007941 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 720555007942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555007943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555007944 putative substrate translocation pore; other site 720555007945 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 720555007946 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 720555007947 catalytic residue [active] 720555007948 allantoate amidohydrolase; Reviewed; Region: PRK09290 720555007949 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 720555007950 active site 720555007951 metal binding site [ion binding]; metal-binding site 720555007952 dimer interface [polypeptide binding]; other site 720555007953 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 720555007954 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 720555007955 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 720555007956 Endonuclease I; Region: Endonuclease_1; cl01003 720555007957 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 720555007958 conserved cys residue [active] 720555007959 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 720555007960 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 720555007961 Walker A/P-loop; other site 720555007962 ATP binding site [chemical binding]; other site 720555007963 Q-loop/lid; other site 720555007964 ABC transporter signature motif; other site 720555007965 Walker B; other site 720555007966 D-loop; other site 720555007967 H-loop/switch region; other site 720555007968 TOBE domain; Region: TOBE; pfam03459 720555007969 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 720555007970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555007971 DNA-binding site [nucleotide binding]; DNA binding site 720555007972 UTRA domain; Region: UTRA; pfam07702 720555007973 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 720555007974 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 720555007975 substrate binding site [chemical binding]; other site 720555007976 ATP binding site [chemical binding]; other site 720555007977 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 720555007978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555007979 dimer interface [polypeptide binding]; other site 720555007980 conserved gate region; other site 720555007981 putative PBP binding loops; other site 720555007982 ABC-ATPase subunit interface; other site 720555007983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555007984 dimer interface [polypeptide binding]; other site 720555007985 conserved gate region; other site 720555007986 putative PBP binding loops; other site 720555007987 ABC-ATPase subunit interface; other site 720555007988 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 720555007989 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 720555007990 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 720555007991 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 720555007992 putative active site [active] 720555007993 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 720555007994 dimer interface [polypeptide binding]; other site 720555007995 active site 720555007996 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 720555007997 GIY-YIG motif/motif A; other site 720555007998 active site 720555007999 catalytic site [active] 720555008000 putative DNA binding site [nucleotide binding]; other site 720555008001 metal binding site [ion binding]; metal-binding site 720555008002 hydroxyglutarate oxidase; Provisional; Region: PRK11728 720555008003 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 720555008004 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 720555008005 FeS assembly protein SufB; Region: sufB; TIGR01980 720555008006 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 720555008007 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 720555008008 trimerization site [polypeptide binding]; other site 720555008009 active site 720555008010 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 720555008011 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 720555008012 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 720555008013 catalytic residue [active] 720555008014 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 720555008015 FeS assembly protein SufD; Region: sufD; TIGR01981 720555008016 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 720555008017 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 720555008018 Walker A/P-loop; other site 720555008019 ATP binding site [chemical binding]; other site 720555008020 Q-loop/lid; other site 720555008021 ABC transporter signature motif; other site 720555008022 Walker B; other site 720555008023 D-loop; other site 720555008024 H-loop/switch region; other site 720555008025 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 720555008026 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 720555008027 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 720555008028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555008029 conserved gate region; other site 720555008030 ABC-ATPase subunit interface; other site 720555008031 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 720555008032 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 720555008033 Walker A/P-loop; other site 720555008034 ATP binding site [chemical binding]; other site 720555008035 Q-loop/lid; other site 720555008036 ABC transporter signature motif; other site 720555008037 Walker B; other site 720555008038 D-loop; other site 720555008039 H-loop/switch region; other site 720555008040 NIL domain; Region: NIL; pfam09383 720555008041 SCP-2 sterol transfer family; Region: SCP2; pfam02036 720555008042 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 720555008043 catalytic residues [active] 720555008044 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 720555008045 putative active site [active] 720555008046 putative metal binding site [ion binding]; other site 720555008047 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 720555008048 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 720555008049 lipoyl attachment site [posttranslational modification]; other site 720555008050 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 720555008051 ArsC family; Region: ArsC; pfam03960 720555008052 putative ArsC-like catalytic residues; other site 720555008053 putative TRX-like catalytic residues [active] 720555008054 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 720555008055 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 720555008056 active site 720555008057 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 720555008058 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 720555008059 dimer interface [polypeptide binding]; other site 720555008060 active site 720555008061 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 720555008062 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 720555008063 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 720555008064 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 720555008065 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 720555008066 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 720555008067 substrate binding site [chemical binding]; other site 720555008068 oxyanion hole (OAH) forming residues; other site 720555008069 trimer interface [polypeptide binding]; other site 720555008070 Proline dehydrogenase; Region: Pro_dh; cl03282 720555008071 Coat F domain; Region: Coat_F; pfam07875 720555008072 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555008073 MarR family; Region: MarR; pfam01047 720555008074 MarR family; Region: MarR_2; cl17246 720555008075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555008076 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555008077 putative substrate translocation pore; other site 720555008078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555008079 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 720555008080 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 720555008081 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 720555008082 Walker A/P-loop; other site 720555008083 ATP binding site [chemical binding]; other site 720555008084 Q-loop/lid; other site 720555008085 ABC transporter signature motif; other site 720555008086 Walker B; other site 720555008087 D-loop; other site 720555008088 H-loop/switch region; other site 720555008089 YusW-like protein; Region: YusW; pfam14039 720555008090 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 720555008091 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 720555008092 active site 720555008093 Zn binding site [ion binding]; other site 720555008094 short chain dehydrogenase; Provisional; Region: PRK06914 720555008095 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 720555008096 NADP binding site [chemical binding]; other site 720555008097 active site 720555008098 steroid binding site; other site 720555008099 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 720555008100 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 720555008101 dimerization interface [polypeptide binding]; other site 720555008102 DPS ferroxidase diiron center [ion binding]; other site 720555008103 ion pore; other site 720555008104 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 720555008105 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 720555008106 protein binding site [polypeptide binding]; other site 720555008107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555008108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555008109 active site 720555008110 phosphorylation site [posttranslational modification] 720555008111 intermolecular recognition site; other site 720555008112 dimerization interface [polypeptide binding]; other site 720555008113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 720555008114 DNA binding site [nucleotide binding] 720555008115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 720555008116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 720555008117 dimerization interface [polypeptide binding]; other site 720555008118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555008119 dimer interface [polypeptide binding]; other site 720555008120 phosphorylation site [posttranslational modification] 720555008121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555008122 ATP binding site [chemical binding]; other site 720555008123 Mg2+ binding site [ion binding]; other site 720555008124 G-X-G motif; other site 720555008125 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555008126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555008127 fumarate hydratase; Reviewed; Region: fumC; PRK00485 720555008128 Class II fumarases; Region: Fumarase_classII; cd01362 720555008129 active site 720555008130 tetramer interface [polypeptide binding]; other site 720555008131 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 720555008132 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 720555008133 Spore germination protein; Region: Spore_permease; pfam03845 720555008134 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 720555008135 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 720555008136 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 720555008137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555008138 active site 720555008139 phosphorylation site [posttranslational modification] 720555008140 intermolecular recognition site; other site 720555008141 dimerization interface [polypeptide binding]; other site 720555008142 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 720555008143 DNA binding residues [nucleotide binding] 720555008144 dimerization interface [polypeptide binding]; other site 720555008145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 720555008146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 720555008147 dimerization interface [polypeptide binding]; other site 720555008148 Histidine kinase; Region: HisKA_3; pfam07730 720555008149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555008150 ATP binding site [chemical binding]; other site 720555008151 Mg2+ binding site [ion binding]; other site 720555008152 G-X-G motif; other site 720555008153 Predicted membrane protein [Function unknown]; Region: COG4758 720555008154 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 720555008155 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 720555008156 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 720555008157 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 720555008158 PspA/IM30 family; Region: PspA_IM30; pfam04012 720555008159 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 720555008160 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555008161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555008162 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 720555008163 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 720555008164 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 720555008165 Walker A/P-loop; other site 720555008166 ATP binding site [chemical binding]; other site 720555008167 Q-loop/lid; other site 720555008168 ABC transporter signature motif; other site 720555008169 Walker B; other site 720555008170 D-loop; other site 720555008171 H-loop/switch region; other site 720555008172 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 720555008173 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 720555008174 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555008175 dimer interface [polypeptide binding]; other site 720555008176 ABC-ATPase subunit interface; other site 720555008177 putative PBP binding regions; other site 720555008178 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 720555008179 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 720555008180 putative binding site residues; other site 720555008181 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 720555008182 classical (c) SDRs; Region: SDR_c; cd05233 720555008183 NAD(P) binding site [chemical binding]; other site 720555008184 active site 720555008185 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 720555008186 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 720555008187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555008188 dimer interface [polypeptide binding]; other site 720555008189 phosphorylation site [posttranslational modification] 720555008190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555008191 ATP binding site [chemical binding]; other site 720555008192 Mg2+ binding site [ion binding]; other site 720555008193 G-X-G motif; other site 720555008194 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555008195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555008196 active site 720555008197 phosphorylation site [posttranslational modification] 720555008198 intermolecular recognition site; other site 720555008199 dimerization interface [polypeptide binding]; other site 720555008200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 720555008201 DNA binding site [nucleotide binding] 720555008202 hypothetical protein; Provisional; Region: PRK14082 720555008203 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 720555008204 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555008205 DNA binding residues [nucleotide binding] 720555008206 YvrJ protein family; Region: YvrJ; pfam12841 720555008207 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 720555008208 Cupin; Region: Cupin_1; smart00835 720555008209 Cupin; Region: Cupin_1; smart00835 720555008210 Regulatory protein YrvL; Region: YrvL; pfam14184 720555008211 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 720555008212 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 720555008213 FtsX-like permease family; Region: FtsX; pfam02687 720555008214 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 720555008215 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 720555008216 Walker A/P-loop; other site 720555008217 ATP binding site [chemical binding]; other site 720555008218 Q-loop/lid; other site 720555008219 ABC transporter signature motif; other site 720555008220 Walker B; other site 720555008221 D-loop; other site 720555008222 H-loop/switch region; other site 720555008223 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 720555008224 HlyD family secretion protein; Region: HlyD_3; pfam13437 720555008225 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 720555008226 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 720555008227 Walker A/P-loop; other site 720555008228 ATP binding site [chemical binding]; other site 720555008229 Q-loop/lid; other site 720555008230 ABC transporter signature motif; other site 720555008231 Walker B; other site 720555008232 D-loop; other site 720555008233 H-loop/switch region; other site 720555008234 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 720555008235 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555008236 ABC-ATPase subunit interface; other site 720555008237 dimer interface [polypeptide binding]; other site 720555008238 putative PBP binding regions; other site 720555008239 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 720555008240 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555008241 ABC-ATPase subunit interface; other site 720555008242 dimer interface [polypeptide binding]; other site 720555008243 putative PBP binding regions; other site 720555008244 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 720555008245 putative ligand binding residues [chemical binding]; other site 720555008246 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 720555008247 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 720555008248 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; cl09798 720555008249 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555008250 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555008251 dimerization interface [polypeptide binding]; other site 720555008252 putative DNA binding site [nucleotide binding]; other site 720555008253 putative Zn2+ binding site [ion binding]; other site 720555008254 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 720555008255 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 720555008256 Sulfatase; Region: Sulfatase; pfam00884 720555008257 DNA binding domain, excisionase family; Region: excise; TIGR01764 720555008258 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 720555008259 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 720555008260 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 720555008261 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 720555008262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555008263 dimer interface [polypeptide binding]; other site 720555008264 conserved gate region; other site 720555008265 putative PBP binding loops; other site 720555008266 ABC-ATPase subunit interface; other site 720555008267 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555008268 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 720555008269 ligand binding site [chemical binding]; other site 720555008270 dimer interface [polypeptide binding]; other site 720555008271 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 720555008272 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 720555008273 active site 720555008274 catalytic tetrad [active] 720555008275 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 720555008276 sulfite reductase subunit beta; Provisional; Region: PRK13504 720555008277 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 720555008278 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 720555008279 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 720555008280 Flavodoxin; Region: Flavodoxin_1; pfam00258 720555008281 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 720555008282 FAD binding pocket [chemical binding]; other site 720555008283 FAD binding motif [chemical binding]; other site 720555008284 catalytic residues [active] 720555008285 NAD binding pocket [chemical binding]; other site 720555008286 phosphate binding motif [ion binding]; other site 720555008287 beta-alpha-beta structure motif; other site 720555008288 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 720555008289 Part of AAA domain; Region: AAA_19; pfam13245 720555008290 Family description; Region: UvrD_C_2; pfam13538 720555008291 Predicted membrane protein [Function unknown]; Region: COG2860 720555008292 UPF0126 domain; Region: UPF0126; pfam03458 720555008293 UPF0126 domain; Region: UPF0126; pfam03458 720555008294 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 720555008295 active site 720555008296 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 720555008297 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 720555008298 Thioredoxin; Region: Thioredoxin_4; pfam13462 720555008299 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 720555008300 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 720555008301 metal-binding site [ion binding] 720555008302 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 720555008303 Soluble P-type ATPase [General function prediction only]; Region: COG4087 720555008304 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 720555008305 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 720555008306 metal-binding site [ion binding] 720555008307 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 720555008308 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 720555008309 metal-binding site [ion binding] 720555008310 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 720555008311 Soluble P-type ATPase [General function prediction only]; Region: COG4087 720555008312 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 720555008313 metal-binding site [ion binding] 720555008314 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 720555008315 putative homodimer interface [polypeptide binding]; other site 720555008316 putative homotetramer interface [polypeptide binding]; other site 720555008317 allosteric switch controlling residues; other site 720555008318 putative metal binding site [ion binding]; other site 720555008319 putative homodimer-homodimer interface [polypeptide binding]; other site 720555008320 putative oxidoreductase; Provisional; Region: PRK11579 720555008321 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 720555008322 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 720555008323 azoreductase; Reviewed; Region: PRK00170 720555008324 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 720555008325 Predicted membrane protein [Function unknown]; Region: COG1289 720555008326 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 720555008327 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555008328 MarR family; Region: MarR; pfam01047 720555008329 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 720555008330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555008331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555008332 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 720555008333 active site 720555008334 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 720555008335 SmpB-tmRNA interface; other site 720555008336 ribonuclease R; Region: RNase_R; TIGR02063 720555008337 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 720555008338 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 720555008339 RNB domain; Region: RNB; pfam00773 720555008340 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 720555008341 RNA binding site [nucleotide binding]; other site 720555008342 Esterase/lipase [General function prediction only]; Region: COG1647 720555008343 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 720555008344 Preprotein translocase SecG subunit; Region: SecG; pfam03840 720555008345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555008346 salt bridge; other site 720555008347 non-specific DNA binding site [nucleotide binding]; other site 720555008348 sequence-specific DNA binding site [nucleotide binding]; other site 720555008349 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 720555008350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555008351 non-specific DNA binding site [nucleotide binding]; other site 720555008352 salt bridge; other site 720555008353 sequence-specific DNA binding site [nucleotide binding]; other site 720555008354 conjugal transfer protein TrbA; Provisional; Region: PRK13890 720555008355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555008356 non-specific DNA binding site [nucleotide binding]; other site 720555008357 salt bridge; other site 720555008358 sequence-specific DNA binding site [nucleotide binding]; other site 720555008359 Predicted transcriptional regulators [Transcription]; Region: COG1733 720555008360 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 720555008361 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 720555008362 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 720555008363 dimerization interface [polypeptide binding]; other site 720555008364 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 720555008365 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 720555008366 dimer interface [polypeptide binding]; other site 720555008367 putative CheW interface [polypeptide binding]; other site 720555008368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555008369 dimer interface [polypeptide binding]; other site 720555008370 conserved gate region; other site 720555008371 putative PBP binding loops; other site 720555008372 ABC-ATPase subunit interface; other site 720555008373 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 720555008374 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 720555008375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555008376 dimer interface [polypeptide binding]; other site 720555008377 conserved gate region; other site 720555008378 putative PBP binding loops; other site 720555008379 ABC-ATPase subunit interface; other site 720555008380 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 720555008381 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 720555008382 Walker A/P-loop; other site 720555008383 ATP binding site [chemical binding]; other site 720555008384 Q-loop/lid; other site 720555008385 ABC transporter signature motif; other site 720555008386 Walker B; other site 720555008387 D-loop; other site 720555008388 H-loop/switch region; other site 720555008389 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 720555008390 Predicted transcriptional regulators [Transcription]; Region: COG1510 720555008391 MarR family; Region: MarR_2; pfam12802 720555008392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555008393 dimer interface [polypeptide binding]; other site 720555008394 conserved gate region; other site 720555008395 putative PBP binding loops; other site 720555008396 ABC-ATPase subunit interface; other site 720555008397 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 720555008398 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 720555008399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555008400 dimer interface [polypeptide binding]; other site 720555008401 conserved gate region; other site 720555008402 putative PBP binding loops; other site 720555008403 ABC-ATPase subunit interface; other site 720555008404 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 720555008405 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 720555008406 Walker A/P-loop; other site 720555008407 ATP binding site [chemical binding]; other site 720555008408 Q-loop/lid; other site 720555008409 ABC transporter signature motif; other site 720555008410 Walker B; other site 720555008411 D-loop; other site 720555008412 H-loop/switch region; other site 720555008413 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 720555008414 Predicted transcriptional regulators [Transcription]; Region: COG1510 720555008415 MarR family; Region: MarR_2; pfam12802 720555008416 MarC family integral membrane protein; Region: MarC; cl00919 720555008417 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 720555008418 Double zinc ribbon; Region: DZR; pfam12773 720555008419 Predicted membrane protein [Function unknown]; Region: COG4640 720555008420 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 720555008421 Eukaryotic initiation factor 4E; Region: IF4E; cl02106 720555008422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555008423 Coenzyme A binding pocket [chemical binding]; other site 720555008424 H+ Antiporter protein; Region: 2A0121; TIGR00900 720555008425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555008426 putative substrate translocation pore; other site 720555008427 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 720555008428 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 720555008429 WbqC-like protein family; Region: WbqC; pfam08889 720555008430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 720555008431 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 720555008432 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 720555008433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 720555008434 catalytic residue [active] 720555008435 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 720555008436 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 720555008437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555008438 NAD(P) binding site [chemical binding]; other site 720555008439 active site 720555008440 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 720555008441 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 720555008442 inhibitor-cofactor binding pocket; inhibition site 720555008443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555008444 catalytic residue [active] 720555008445 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 720555008446 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 720555008447 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 720555008448 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 720555008449 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 720555008450 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 720555008451 PA/protease domain interface [polypeptide binding]; other site 720555008452 putative integrin binding motif; other site 720555008453 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 720555008454 Peptidase family M28; Region: Peptidase_M28; pfam04389 720555008455 metal binding site [ion binding]; metal-binding site 720555008456 enolase; Provisional; Region: eno; PRK00077 720555008457 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 720555008458 dimer interface [polypeptide binding]; other site 720555008459 metal binding site [ion binding]; metal-binding site 720555008460 substrate binding pocket [chemical binding]; other site 720555008461 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 720555008462 phosphoglyceromutase; Provisional; Region: PRK05434 720555008463 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 720555008464 triosephosphate isomerase; Provisional; Region: PRK14565 720555008465 substrate binding site [chemical binding]; other site 720555008466 dimer interface [polypeptide binding]; other site 720555008467 catalytic triad [active] 720555008468 Phosphoglycerate kinase; Region: PGK; pfam00162 720555008469 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 720555008470 substrate binding site [chemical binding]; other site 720555008471 hinge regions; other site 720555008472 ADP binding site [chemical binding]; other site 720555008473 catalytic site [active] 720555008474 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 720555008475 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 720555008476 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 720555008477 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 720555008478 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 720555008479 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 720555008480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555008481 putative substrate translocation pore; other site 720555008482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555008483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555008484 DNA-binding site [nucleotide binding]; DNA binding site 720555008485 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 720555008486 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 720555008487 putative dimerization interface [polypeptide binding]; other site 720555008488 putative ligand binding site [chemical binding]; other site 720555008489 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 720555008490 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 720555008491 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 720555008492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555008493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555008494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 720555008495 dimerization interface [polypeptide binding]; other site 720555008496 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 720555008497 EamA-like transporter family; Region: EamA; pfam00892 720555008498 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 720555008499 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 720555008500 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 720555008501 active site 720555008502 Uncharacterized conserved protein [Function unknown]; Region: COG1556 720555008503 iron-sulfur cluster-binding protein; Region: TIGR00273 720555008504 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 720555008505 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 720555008506 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 720555008507 Cysteine-rich domain; Region: CCG; pfam02754 720555008508 Cysteine-rich domain; Region: CCG; pfam02754 720555008509 Transcriptional regulators [Transcription]; Region: FadR; COG2186 720555008510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555008511 DNA-binding site [nucleotide binding]; DNA binding site 720555008512 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 720555008513 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 720555008514 L-lactate permease; Region: Lactate_perm; pfam02652 720555008515 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 720555008516 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 720555008517 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 720555008518 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 720555008519 YvfG protein; Region: YvfG; pfam09628 720555008520 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 720555008521 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 720555008522 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 720555008523 inhibitor-cofactor binding pocket; inhibition site 720555008524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555008525 catalytic residue [active] 720555008526 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 720555008527 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 720555008528 putative trimer interface [polypeptide binding]; other site 720555008529 putative CoA binding site [chemical binding]; other site 720555008530 Bacterial sugar transferase; Region: Bac_transf; pfam02397 720555008531 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 720555008532 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 720555008533 active site 720555008534 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 720555008535 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 720555008536 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 720555008537 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 720555008538 active site 720555008539 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 720555008540 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 720555008541 putative ADP-binding pocket [chemical binding]; other site 720555008542 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 720555008543 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 720555008544 active site 720555008545 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 720555008546 putative ADP-binding pocket [chemical binding]; other site 720555008547 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 720555008548 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 720555008549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555008550 NAD(P) binding site [chemical binding]; other site 720555008551 active site 720555008552 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 720555008553 NAD(P) binding site [chemical binding]; other site 720555008554 homodimer interface [polypeptide binding]; other site 720555008555 substrate binding site [chemical binding]; other site 720555008556 active site 720555008557 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 720555008558 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 720555008559 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 720555008560 Chain length determinant protein; Region: Wzz; cl15801 720555008561 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 720555008562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555008563 non-specific DNA binding site [nucleotide binding]; other site 720555008564 salt bridge; other site 720555008565 sequence-specific DNA binding site [nucleotide binding]; other site 720555008566 Anti-repressor SinI; Region: SinI; pfam08671 720555008567 potential frameshift: common BLAST hit: gi|154687570|ref|YP_001422731.1| PnbA 720555008568 potential frameshift: common BLAST hit: gi|154687570|ref|YP_001422731.1| PnbA 720555008569 Transcriptional regulators [Transcription]; Region: MarR; COG1846 720555008570 MarR family; Region: MarR_2; pfam12802 720555008571 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 720555008572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555008573 Walker A/P-loop; other site 720555008574 ATP binding site [chemical binding]; other site 720555008575 Q-loop/lid; other site 720555008576 ABC transporter signature motif; other site 720555008577 Walker B; other site 720555008578 D-loop; other site 720555008579 H-loop/switch region; other site 720555008580 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 720555008581 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 720555008582 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 720555008583 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 720555008584 hypothetical protein; Validated; Region: PRK07581 720555008585 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 720555008586 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555008587 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555008588 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 720555008589 dimerization interface [polypeptide binding]; other site 720555008590 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 720555008591 active site 720555008592 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 720555008593 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 720555008594 substrate binding [chemical binding]; other site 720555008595 active site 720555008596 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 720555008597 amino acid transporter; Region: 2A0306; TIGR00909 720555008598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555008599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555008600 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 720555008601 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 720555008602 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 720555008603 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 720555008604 DinB superfamily; Region: DinB_2; pfam12867 720555008605 DinB family; Region: DinB; cl17821 720555008606 Clp protease; Region: CLP_protease; pfam00574 720555008607 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 720555008608 oligomer interface [polypeptide binding]; other site 720555008609 active site residues [active] 720555008610 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 720555008611 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 720555008612 conserved cys residue [active] 720555008613 TIGR00730 family protein; Region: TIGR00730 720555008614 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 720555008615 metal binding site [ion binding]; metal-binding site 720555008616 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 720555008617 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 720555008618 Sulfate transporter family; Region: Sulfate_transp; pfam00916 720555008619 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 720555008620 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 720555008621 active site clefts [active] 720555008622 zinc binding site [ion binding]; other site 720555008623 dimer interface [polypeptide binding]; other site 720555008624 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 720555008625 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 720555008626 dimerization interface [polypeptide binding]; other site 720555008627 ligand binding site [chemical binding]; other site 720555008628 NADP binding site [chemical binding]; other site 720555008629 catalytic site [active] 720555008630 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 720555008631 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 720555008632 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 720555008633 Walker A/P-loop; other site 720555008634 ATP binding site [chemical binding]; other site 720555008635 Q-loop/lid; other site 720555008636 ABC transporter signature motif; other site 720555008637 Walker B; other site 720555008638 D-loop; other site 720555008639 H-loop/switch region; other site 720555008640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 720555008641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555008642 ATP binding site [chemical binding]; other site 720555008643 Mg2+ binding site [ion binding]; other site 720555008644 G-X-G motif; other site 720555008645 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555008646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555008647 active site 720555008648 phosphorylation site [posttranslational modification] 720555008649 intermolecular recognition site; other site 720555008650 dimerization interface [polypeptide binding]; other site 720555008651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 720555008652 DNA binding site [nucleotide binding] 720555008653 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 720555008654 active site 720555008655 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 720555008656 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 720555008657 dimerization domain swap beta strand [polypeptide binding]; other site 720555008658 regulatory protein interface [polypeptide binding]; other site 720555008659 active site 720555008660 regulatory phosphorylation site [posttranslational modification]; other site 720555008661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 720555008662 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 720555008663 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 720555008664 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 720555008665 phosphate binding site [ion binding]; other site 720555008666 putative substrate binding pocket [chemical binding]; other site 720555008667 dimer interface [polypeptide binding]; other site 720555008668 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 720555008669 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 720555008670 putative active site [active] 720555008671 nucleotide binding site [chemical binding]; other site 720555008672 nudix motif; other site 720555008673 putative metal binding site [ion binding]; other site 720555008674 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 720555008675 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 720555008676 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555008677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 720555008678 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 720555008679 NlpC/P60 family; Region: NLPC_P60; pfam00877 720555008680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555008681 binding surface 720555008682 Tetratricopeptide repeat; Region: TPR_16; pfam13432 720555008683 TPR motif; other site 720555008684 TPR repeat; Region: TPR_11; pfam13414 720555008685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555008686 TPR motif; other site 720555008687 binding surface 720555008688 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 720555008689 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 720555008690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555008691 Walker A/P-loop; other site 720555008692 ATP binding site [chemical binding]; other site 720555008693 Q-loop/lid; other site 720555008694 ABC transporter signature motif; other site 720555008695 Walker B; other site 720555008696 D-loop; other site 720555008697 H-loop/switch region; other site 720555008698 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 720555008699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555008700 Coenzyme A binding pocket [chemical binding]; other site 720555008701 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 720555008702 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 720555008703 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 720555008704 metal binding site [ion binding]; metal-binding site 720555008705 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 720555008706 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 720555008707 substrate binding site [chemical binding]; other site 720555008708 glutamase interaction surface [polypeptide binding]; other site 720555008709 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 720555008710 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 720555008711 catalytic residues [active] 720555008712 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 720555008713 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 720555008714 putative active site [active] 720555008715 oxyanion strand; other site 720555008716 catalytic triad [active] 720555008717 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 720555008718 putative active site pocket [active] 720555008719 4-fold oligomerization interface [polypeptide binding]; other site 720555008720 metal binding residues [ion binding]; metal-binding site 720555008721 3-fold/trimer interface [polypeptide binding]; other site 720555008722 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 720555008723 histidinol dehydrogenase; Region: hisD; TIGR00069 720555008724 NAD binding site [chemical binding]; other site 720555008725 dimerization interface [polypeptide binding]; other site 720555008726 product binding site; other site 720555008727 substrate binding site [chemical binding]; other site 720555008728 zinc binding site [ion binding]; other site 720555008729 catalytic residues [active] 720555008730 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 720555008731 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 720555008732 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 720555008733 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 720555008734 dimer interface [polypeptide binding]; other site 720555008735 motif 1; other site 720555008736 active site 720555008737 motif 2; other site 720555008738 motif 3; other site 720555008739 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 720555008740 putative active site [active] 720555008741 Pectate lyase; Region: Pectate_lyase; pfam03211 720555008742 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 720555008743 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 720555008744 CoA binding site [chemical binding]; other site 720555008745 active site 720555008746 trimer interface [polypeptide binding]; other site 720555008747 pyrophosphatase PpaX; Provisional; Region: PRK13288 720555008748 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 720555008749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555008750 motif II; other site 720555008751 Nucleoside recognition; Region: Gate; pfam07670 720555008752 Nucleoside recognition; Region: Gate; pfam07670 720555008753 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 720555008754 HPr kinase/phosphorylase; Provisional; Region: PRK05428 720555008755 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 720555008756 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 720555008757 Hpr binding site; other site 720555008758 active site 720555008759 homohexamer subunit interaction site [polypeptide binding]; other site 720555008760 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 720555008761 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 720555008762 active site 720555008763 dimer interface [polypeptide binding]; other site 720555008764 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 720555008765 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 720555008766 active site 720555008767 trimer interface [polypeptide binding]; other site 720555008768 allosteric site; other site 720555008769 active site lid [active] 720555008770 hexamer (dimer of trimers) interface [polypeptide binding]; other site 720555008771 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 720555008772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555008773 DNA-binding site [nucleotide binding]; DNA binding site 720555008774 UTRA domain; Region: UTRA; pfam07702 720555008775 Lamin Tail Domain; Region: LTD; pfam00932 720555008776 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 720555008777 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 720555008778 putative active site [active] 720555008779 putative metal binding site [ion binding]; other site 720555008780 Predicted membrane protein [Function unknown]; Region: COG1950 720555008781 PspC domain; Region: PspC; pfam04024 720555008782 Uncharacterized conserved protein [Function unknown]; Region: COG3595 720555008783 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 720555008784 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 720555008785 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 720555008786 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 720555008787 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 720555008788 excinuclease ABC subunit B; Provisional; Region: PRK05298 720555008789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 720555008790 ATP binding site [chemical binding]; other site 720555008791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555008792 nucleotide binding region [chemical binding]; other site 720555008793 ATP-binding site [chemical binding]; other site 720555008794 Ultra-violet resistance protein B; Region: UvrB; pfam12344 720555008795 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 720555008796 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 720555008797 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 720555008798 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 720555008799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555008800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555008801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555008802 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555008803 putative substrate translocation pore; other site 720555008804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555008805 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 720555008806 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 720555008807 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 720555008808 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 720555008809 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 720555008810 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 720555008811 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 720555008812 C-terminal peptidase (prc); Region: prc; TIGR00225 720555008813 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 720555008814 protein binding site [polypeptide binding]; other site 720555008815 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 720555008816 Catalytic dyad [active] 720555008817 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 720555008818 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 720555008819 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 720555008820 FtsX-like permease family; Region: FtsX; pfam02687 720555008821 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 720555008822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555008823 Walker A/P-loop; other site 720555008824 ATP binding site [chemical binding]; other site 720555008825 Q-loop/lid; other site 720555008826 ABC transporter signature motif; other site 720555008827 Walker B; other site 720555008828 D-loop; other site 720555008829 H-loop/switch region; other site 720555008830 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 720555008831 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 720555008832 Uncharacterized conserved protein [Function unknown]; Region: COG1284 720555008833 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 720555008834 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 720555008835 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 720555008836 peptide chain release factor 2; Provisional; Region: PRK06746 720555008837 This domain is found in peptide chain release factors; Region: PCRF; smart00937 720555008838 RF-1 domain; Region: RF-1; pfam00472 720555008839 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 720555008840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 720555008841 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 720555008842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 720555008843 nucleotide binding region [chemical binding]; other site 720555008844 ATP-binding site [chemical binding]; other site 720555008845 SEC-C motif; Region: SEC-C; pfam02810 720555008846 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 720555008847 30S subunit binding site; other site 720555008848 Flagellar protein FliS; Region: FliS; cl00654 720555008849 flagellar capping protein; Validated; Region: fliD; PRK07737 720555008850 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 720555008851 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 720555008852 flagellar protein FlaG; Provisional; Region: PRK07738 720555008853 flagellin; Provisional; Region: PRK12804 720555008854 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 720555008855 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 720555008856 carbon storage regulator; Provisional; Region: PRK01712 720555008857 flagellar assembly protein FliW; Provisional; Region: PRK13285 720555008858 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 720555008859 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 720555008860 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 720555008861 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 720555008862 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 720555008863 FlgN protein; Region: FlgN; pfam05130 720555008864 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 720555008865 flagellar operon protein TIGR03826; Region: YvyF 720555008866 comF family protein; Region: comF; TIGR00201 720555008867 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 720555008868 active site 720555008869 Late competence development protein ComFB; Region: ComFB; pfam10719 720555008870 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 720555008871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 720555008872 ATP binding site [chemical binding]; other site 720555008873 putative Mg++ binding site [ion binding]; other site 720555008874 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555008875 nucleotide binding region [chemical binding]; other site 720555008876 ATP-binding site [chemical binding]; other site 720555008877 EDD domain protein, DegV family; Region: DegV; TIGR00762 720555008878 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 720555008879 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 720555008880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555008881 active site 720555008882 phosphorylation site [posttranslational modification] 720555008883 intermolecular recognition site; other site 720555008884 dimerization interface [polypeptide binding]; other site 720555008885 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 720555008886 DNA binding residues [nucleotide binding] 720555008887 dimerization interface [polypeptide binding]; other site 720555008888 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 720555008889 Histidine kinase; Region: HisKA_3; pfam07730 720555008890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555008891 ATP binding site [chemical binding]; other site 720555008892 Mg2+ binding site [ion binding]; other site 720555008893 G-X-G motif; other site 720555008894 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 720555008895 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 720555008896 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 720555008897 Transcriptional regulator [Transcription]; Region: LytR; COG1316 720555008898 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 720555008899 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 720555008900 Mg++ binding site [ion binding]; other site 720555008901 putative catalytic motif [active] 720555008902 substrate binding site [chemical binding]; other site 720555008903 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 720555008904 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 720555008905 putative homodimer interface [polypeptide binding]; other site 720555008906 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 720555008907 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 720555008908 active site 720555008909 O-Antigen ligase; Region: Wzy_C; pfam04932 720555008910 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 720555008911 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 720555008912 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 720555008913 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 720555008914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 720555008915 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 720555008916 colanic acid exporter; Provisional; Region: PRK10459 720555008917 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 720555008918 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 720555008919 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 720555008920 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 720555008921 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 720555008922 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 720555008923 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 720555008924 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 720555008925 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 720555008926 active site 720555008927 metal binding site [ion binding]; metal-binding site 720555008928 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 720555008929 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 720555008930 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 720555008931 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 720555008932 Stage II sporulation protein; Region: SpoIID; pfam08486 720555008933 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 720555008934 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 720555008935 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 720555008936 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 720555008937 active site 720555008938 homodimer interface [polypeptide binding]; other site 720555008939 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 720555008940 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 720555008941 active site 720555008942 tetramer interface; other site 720555008943 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 720555008944 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 720555008945 Walker A/P-loop; other site 720555008946 ATP binding site [chemical binding]; other site 720555008947 Q-loop/lid; other site 720555008948 ABC transporter signature motif; other site 720555008949 Walker B; other site 720555008950 D-loop; other site 720555008951 H-loop/switch region; other site 720555008952 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 720555008953 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 720555008954 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 720555008955 active site 720555008956 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 720555008957 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 720555008958 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 720555008959 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 720555008960 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 720555008961 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 720555008962 active site 720555008963 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 720555008964 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 720555008965 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 720555008966 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 720555008967 Sporulation related domain; Region: SPOR; pfam05036 720555008968 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 720555008969 Bacterial SH3 domain; Region: SH3_3; pfam08239 720555008970 Lysozyme subfamily 2; Region: LYZ2; smart00047 720555008971 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 720555008972 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 720555008973 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 720555008974 Spore germination protein; Region: Spore_permease; pfam03845 720555008975 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 720555008976 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 720555008977 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 720555008978 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 720555008979 Probable Catalytic site; other site 720555008980 metal-binding site 720555008981 Methyltransferase domain; Region: Methyltransf_23; pfam13489 720555008982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555008983 S-adenosylmethionine binding site [chemical binding]; other site 720555008984 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 720555008985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555008986 putative substrate translocation pore; other site 720555008987 Transcriptional regulator [Transcription]; Region: LytR; COG1316 720555008988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555008989 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 720555008990 active site 720555008991 motif I; other site 720555008992 motif II; other site 720555008993 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555008994 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 720555008995 NlpC/P60 family; Region: NLPC_P60; pfam00877 720555008996 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 720555008997 NlpC/P60 family; Region: NLPC_P60; pfam00877 720555008998 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 720555008999 NlpC/P60 family; Region: NLPC_P60; pfam00877 720555009000 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 720555009001 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 720555009002 putative active site [active] 720555009003 putative metal binding site [ion binding]; other site 720555009004 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 720555009005 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 720555009006 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 720555009007 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 720555009008 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 720555009009 Spore germination protein; Region: Spore_permease; cl17796 720555009010 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 720555009011 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 720555009012 Transcriptional regulators [Transcription]; Region: PurR; COG1609 720555009013 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 720555009014 DNA binding site [nucleotide binding] 720555009015 domain linker motif; other site 720555009016 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 720555009017 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 720555009018 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 720555009019 substrate binding site [chemical binding]; other site 720555009020 dimer interface [polypeptide binding]; other site 720555009021 ATP binding site [chemical binding]; other site 720555009022 D-ribose pyranase; Provisional; Region: PRK11797 720555009023 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 720555009024 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 720555009025 Walker A/P-loop; other site 720555009026 ATP binding site [chemical binding]; other site 720555009027 Q-loop/lid; other site 720555009028 ABC transporter signature motif; other site 720555009029 Walker B; other site 720555009030 D-loop; other site 720555009031 H-loop/switch region; other site 720555009032 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 720555009033 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 720555009034 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 720555009035 TM-ABC transporter signature motif; other site 720555009036 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 720555009037 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 720555009038 ligand binding site [chemical binding]; other site 720555009039 dimerization interface [polypeptide binding]; other site 720555009040 Bacterial SH3 domain homologues; Region: SH3b; smart00287 720555009041 Bacterial SH3 domain homologues; Region: SH3b; smart00287 720555009042 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 720555009043 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 720555009044 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 720555009045 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 720555009046 acetolactate synthase; Reviewed; Region: PRK08617 720555009047 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 720555009048 PYR/PP interface [polypeptide binding]; other site 720555009049 dimer interface [polypeptide binding]; other site 720555009050 TPP binding site [chemical binding]; other site 720555009051 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 720555009052 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 720555009053 TPP-binding site [chemical binding]; other site 720555009054 dimer interface [polypeptide binding]; other site 720555009055 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 720555009056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555009057 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 720555009058 putative dimerization interface [polypeptide binding]; other site 720555009059 putative substrate binding pocket [chemical binding]; other site 720555009060 CotH protein; Region: CotH; pfam08757 720555009061 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 720555009062 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 720555009063 HTH domain; Region: HTH_11; pfam08279 720555009064 PRD domain; Region: PRD; pfam00874 720555009065 PRD domain; Region: PRD; pfam00874 720555009066 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 720555009067 active site 720555009068 P-loop; other site 720555009069 phosphorylation site [posttranslational modification] 720555009070 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 720555009071 active site 720555009072 phosphorylation site [posttranslational modification] 720555009073 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 720555009074 active site 720555009075 P-loop; other site 720555009076 phosphorylation site [posttranslational modification] 720555009077 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 720555009078 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 720555009079 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 720555009080 substrate binding site [chemical binding]; other site 720555009081 hexamer interface [polypeptide binding]; other site 720555009082 metal binding site [ion binding]; metal-binding site 720555009083 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 720555009084 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 720555009085 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 720555009086 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 720555009087 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555009088 putative DNA binding site [nucleotide binding]; other site 720555009089 putative Zn2+ binding site [ion binding]; other site 720555009090 AsnC family; Region: AsnC_trans_reg; pfam01037 720555009091 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 720555009092 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 720555009093 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 720555009094 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 720555009095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555009096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555009097 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 720555009098 dimerization interface [polypeptide binding]; other site 720555009099 LXG domain of WXG superfamily; Region: LXG; pfam04740 720555009100 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 720555009101 Cytotoxic; Region: Cytotoxic; pfam09000 720555009102 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 720555009103 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 720555009104 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 720555009105 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 720555009106 Bacterial sugar transferase; Region: Bac_transf; cl00939 720555009107 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 720555009108 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 720555009109 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 720555009110 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 720555009111 Chain length determinant protein; Region: Wzz; cl15801 720555009112 SWIM zinc finger; Region: SWIM; pfam04434 720555009113 SNF2 Helicase protein; Region: DUF3670; pfam12419 720555009114 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 720555009115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 720555009116 ATP binding site [chemical binding]; other site 720555009117 putative Mg++ binding site [ion binding]; other site 720555009118 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 720555009119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555009120 nucleotide binding region [chemical binding]; other site 720555009121 ATP-binding site [chemical binding]; other site 720555009122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555009123 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 720555009124 active site 720555009125 motif I; other site 720555009126 motif II; other site 720555009127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555009128 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 720555009129 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 720555009130 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 720555009131 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 720555009132 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 720555009133 dimer interface [polypeptide binding]; other site 720555009134 ssDNA binding site [nucleotide binding]; other site 720555009135 tetramer (dimer of dimers) interface [polypeptide binding]; other site 720555009136 YwpF-like protein; Region: YwpF; pfam14183 720555009137 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 720555009138 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 720555009139 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 720555009140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555009141 binding surface 720555009142 TPR motif; other site 720555009143 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555009144 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 720555009145 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 720555009146 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 720555009147 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 720555009148 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 720555009149 rod shape-determining protein Mbl; Provisional; Region: PRK13928 720555009150 MreB and similar proteins; Region: MreB_like; cd10225 720555009151 nucleotide binding site [chemical binding]; other site 720555009152 Mg binding site [ion binding]; other site 720555009153 putative protofilament interaction site [polypeptide binding]; other site 720555009154 RodZ interaction site [polypeptide binding]; other site 720555009155 Stage III sporulation protein D; Region: SpoIIID; pfam12116 720555009156 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555009157 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555009158 putative Zn2+ binding site [ion binding]; other site 720555009159 putative DNA binding site [nucleotide binding]; other site 720555009160 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555009161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555009162 putative substrate translocation pore; other site 720555009163 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 720555009164 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 720555009165 Na binding site [ion binding]; other site 720555009166 putative substrate binding site [chemical binding]; other site 720555009167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555009168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555009169 putative substrate translocation pore; other site 720555009170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555009171 Isochorismatase family; Region: Isochorismatase; pfam00857 720555009172 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 720555009173 catalytic triad [active] 720555009174 conserved cis-peptide bond; other site 720555009175 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 720555009176 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 720555009177 Nitrogen regulatory protein P-II; Region: P-II; smart00938 720555009178 cell division protein FtsW; Region: ftsW; TIGR02614 720555009179 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 720555009180 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 720555009181 active site 720555009182 VanZ like family; Region: VanZ; pfam04892 720555009183 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 720555009184 Peptidase family M23; Region: Peptidase_M23; pfam01551 720555009185 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 720555009186 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 720555009187 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 720555009188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555009189 NAD(P) binding site [chemical binding]; other site 720555009190 active site 720555009191 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 720555009192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555009193 NAD(P) binding site [chemical binding]; other site 720555009194 active site 720555009195 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 720555009196 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 720555009197 inhibitor-cofactor binding pocket; inhibition site 720555009198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555009199 catalytic residue [active] 720555009200 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 720555009201 ligand binding site; other site 720555009202 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 720555009203 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 720555009204 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 720555009205 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 720555009206 pseudaminic acid synthase; Region: PseI; TIGR03586 720555009207 NeuB family; Region: NeuB; pfam03102 720555009208 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 720555009209 NeuB binding interface [polypeptide binding]; other site 720555009210 putative substrate binding site [chemical binding]; other site 720555009211 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 720555009212 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 720555009213 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 720555009214 putative active site [active] 720555009215 catalytic site [active] 720555009216 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 720555009217 putative active site [active] 720555009218 catalytic site [active] 720555009219 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 720555009220 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 720555009221 DNA binding residues [nucleotide binding] 720555009222 dimer interface [polypeptide binding]; other site 720555009223 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 720555009224 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 720555009225 NADH(P)-binding; Region: NAD_binding_10; pfam13460 720555009226 NAD binding site [chemical binding]; other site 720555009227 substrate binding site [chemical binding]; other site 720555009228 putative active site [active] 720555009229 Transcriptional regulator; Region: Rrf2; pfam02082 720555009230 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 720555009231 urease subunit alpha; Reviewed; Region: ureC; PRK13207 720555009232 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 720555009233 subunit interactions [polypeptide binding]; other site 720555009234 active site 720555009235 flap region; other site 720555009236 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 720555009237 gamma-beta subunit interface [polypeptide binding]; other site 720555009238 alpha-beta subunit interface [polypeptide binding]; other site 720555009239 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 720555009240 alpha-gamma subunit interface [polypeptide binding]; other site 720555009241 beta-gamma subunit interface [polypeptide binding]; other site 720555009242 CsbD-like; Region: CsbD; pfam05532 720555009243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555009244 TPR motif; other site 720555009245 binding surface 720555009246 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 720555009247 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555009248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555009249 binding surface 720555009250 TPR motif; other site 720555009251 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 720555009252 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 720555009253 FeS/SAM binding site; other site 720555009254 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 720555009255 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 720555009256 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 720555009257 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 720555009258 metal ion-dependent adhesion site (MIDAS); other site 720555009259 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 720555009260 metal ion-dependent adhesion site (MIDAS); other site 720555009261 stage II sporulation protein D; Region: spore_II_D; TIGR02870 720555009262 Stage II sporulation protein; Region: SpoIID; pfam08486 720555009263 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 720555009264 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 720555009265 hinge; other site 720555009266 active site 720555009267 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 720555009268 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 720555009269 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 720555009270 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 720555009271 gamma subunit interface [polypeptide binding]; other site 720555009272 epsilon subunit interface [polypeptide binding]; other site 720555009273 LBP interface [polypeptide binding]; other site 720555009274 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 720555009275 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 720555009276 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 720555009277 alpha subunit interaction interface [polypeptide binding]; other site 720555009278 Walker A motif; other site 720555009279 ATP binding site [chemical binding]; other site 720555009280 Walker B motif; other site 720555009281 inhibitor binding site; inhibition site 720555009282 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 720555009283 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 720555009284 core domain interface [polypeptide binding]; other site 720555009285 delta subunit interface [polypeptide binding]; other site 720555009286 epsilon subunit interface [polypeptide binding]; other site 720555009287 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 720555009288 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 720555009289 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 720555009290 beta subunit interaction interface [polypeptide binding]; other site 720555009291 Walker A motif; other site 720555009292 ATP binding site [chemical binding]; other site 720555009293 Walker B motif; other site 720555009294 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 720555009295 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 720555009296 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 720555009297 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 720555009298 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 720555009299 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 720555009300 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 720555009301 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 720555009302 ATP synthase I chain; Region: ATP_synt_I; pfam03899 720555009303 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 720555009304 active site 720555009305 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 720555009306 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 720555009307 dimer interface [polypeptide binding]; other site 720555009308 active site 720555009309 glycine-pyridoxal phosphate binding site [chemical binding]; other site 720555009310 folate binding site [chemical binding]; other site 720555009311 hypothetical protein; Provisional; Region: PRK13690 720555009312 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 720555009313 Low molecular weight phosphatase family; Region: LMWPc; cd00115 720555009314 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 720555009315 active site 720555009316 Predicted membrane protein [Function unknown]; Region: COG1971 720555009317 Domain of unknown function DUF; Region: DUF204; pfam02659 720555009318 Domain of unknown function DUF; Region: DUF204; pfam02659 720555009319 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 720555009320 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 720555009321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 720555009322 stage II sporulation protein R; Region: spore_II_R; TIGR02837 720555009323 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 720555009324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555009325 S-adenosylmethionine binding site [chemical binding]; other site 720555009326 peptide chain release factor 1; Validated; Region: prfA; PRK00591 720555009327 This domain is found in peptide chain release factors; Region: PCRF; smart00937 720555009328 RF-1 domain; Region: RF-1; pfam00472 720555009329 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 720555009330 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555009331 putative metal binding site [ion binding]; other site 720555009332 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 720555009333 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 720555009334 DNA binding residues [nucleotide binding] 720555009335 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 720555009336 malate dehydrogenase; Provisional; Region: PRK13529 720555009337 Malic enzyme, N-terminal domain; Region: malic; pfam00390 720555009338 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 720555009339 NAD(P) binding site [chemical binding]; other site 720555009340 thymidine kinase; Provisional; Region: PRK04296 720555009341 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 720555009342 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 720555009343 transcription termination factor Rho; Provisional; Region: rho; PRK09376 720555009344 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 720555009345 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 720555009346 RNA binding site [nucleotide binding]; other site 720555009347 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 720555009348 multimer interface [polypeptide binding]; other site 720555009349 Walker A motif; other site 720555009350 ATP binding site [chemical binding]; other site 720555009351 Walker B motif; other site 720555009352 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 720555009353 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 720555009354 putative active site [active] 720555009355 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 720555009356 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 720555009357 hinge; other site 720555009358 active site 720555009359 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 720555009360 active site 720555009361 intersubunit interactions; other site 720555009362 catalytic residue [active] 720555009363 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 720555009364 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 720555009365 intersubunit interface [polypeptide binding]; other site 720555009366 active site 720555009367 zinc binding site [ion binding]; other site 720555009368 Na+ binding site [ion binding]; other site 720555009369 Response regulator receiver domain; Region: Response_reg; pfam00072 720555009370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555009371 active site 720555009372 phosphorylation site [posttranslational modification] 720555009373 intermolecular recognition site; other site 720555009374 dimerization interface [polypeptide binding]; other site 720555009375 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 720555009376 CTP synthetase; Validated; Region: pyrG; PRK05380 720555009377 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 720555009378 Catalytic site [active] 720555009379 active site 720555009380 UTP binding site [chemical binding]; other site 720555009381 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 720555009382 active site 720555009383 putative oxyanion hole; other site 720555009384 catalytic triad [active] 720555009385 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 720555009386 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 720555009387 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 720555009388 FAD binding site [chemical binding]; other site 720555009389 homotetramer interface [polypeptide binding]; other site 720555009390 substrate binding pocket [chemical binding]; other site 720555009391 catalytic base [active] 720555009392 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 720555009393 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 720555009394 4Fe-4S binding domain; Region: Fer4; cl02805 720555009395 Cysteine-rich domain; Region: CCG; pfam02754 720555009396 Cysteine-rich domain; Region: CCG; pfam02754 720555009397 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 720555009398 putative active site [active] 720555009399 catalytic site [active] 720555009400 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 720555009401 PLD-like domain; Region: PLDc_2; pfam13091 720555009402 putative active site [active] 720555009403 catalytic site [active] 720555009404 UV-endonuclease UvdE; Region: UvdE; cl10036 720555009405 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 720555009406 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 720555009407 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 720555009408 folate binding site [chemical binding]; other site 720555009409 NADP+ binding site [chemical binding]; other site 720555009410 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 720555009411 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 720555009412 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 720555009413 Walker A/P-loop; other site 720555009414 ATP binding site [chemical binding]; other site 720555009415 Q-loop/lid; other site 720555009416 ABC transporter signature motif; other site 720555009417 Walker B; other site 720555009418 D-loop; other site 720555009419 H-loop/switch region; other site 720555009420 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 720555009421 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 720555009422 putative active site [active] 720555009423 catalytic site [active] 720555009424 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 720555009425 putative active site [active] 720555009426 catalytic site [active] 720555009427 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 720555009428 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 720555009429 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 720555009430 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 720555009431 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 720555009432 [4Fe-4S] binding site [ion binding]; other site 720555009433 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 720555009434 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 720555009435 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 720555009436 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 720555009437 molybdopterin cofactor binding site; other site 720555009438 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 720555009439 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 720555009440 flexible hinge region; other site 720555009441 YwiC-like protein; Region: YwiC; pfam14256 720555009442 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 720555009443 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 720555009444 ligand binding site [chemical binding]; other site 720555009445 flexible hinge region; other site 720555009446 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 720555009447 putative switch regulator; other site 720555009448 non-specific DNA interactions [nucleotide binding]; other site 720555009449 DNA binding site [nucleotide binding] 720555009450 sequence specific DNA binding site [nucleotide binding]; other site 720555009451 putative cAMP binding site [chemical binding]; other site 720555009452 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 720555009453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555009454 putative substrate translocation pore; other site 720555009455 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 720555009456 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 720555009457 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 720555009458 active site 720555009459 HIGH motif; other site 720555009460 KMSK motif region; other site 720555009461 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 720555009462 tRNA binding surface [nucleotide binding]; other site 720555009463 anticodon binding site; other site 720555009464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 720555009465 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 720555009466 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 720555009467 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 720555009468 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 720555009469 FeS/SAM binding site; other site 720555009470 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 720555009471 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 720555009472 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 720555009473 Walker A/P-loop; other site 720555009474 ATP binding site [chemical binding]; other site 720555009475 Q-loop/lid; other site 720555009476 ABC transporter signature motif; other site 720555009477 Walker B; other site 720555009478 D-loop; other site 720555009479 H-loop/switch region; other site 720555009480 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 720555009481 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 720555009482 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 720555009483 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 720555009484 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 720555009485 Uncharacterized conserved protein [Function unknown]; Region: COG3391 720555009486 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 720555009487 Uncharacterized conserved protein [Function unknown]; Region: COG3391 720555009488 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 720555009489 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 720555009490 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 720555009491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555009492 binding surface 720555009493 TPR motif; other site 720555009494 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555009495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555009496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555009497 TPR motif; other site 720555009498 binding surface 720555009499 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 720555009500 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 720555009501 agmatinase; Region: agmatinase; TIGR01230 720555009502 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 720555009503 putative active site [active] 720555009504 Mn binding site [ion binding]; other site 720555009505 spermidine synthase; Provisional; Region: PRK00811 720555009506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555009507 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 720555009508 Transglycosylase; Region: Transgly; pfam00912 720555009509 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 720555009510 YwhD family; Region: YwhD; pfam08741 720555009511 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 720555009512 Peptidase family M50; Region: Peptidase_M50; pfam02163 720555009513 active site 720555009514 putative substrate binding region [chemical binding]; other site 720555009515 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 720555009516 active site 1 [active] 720555009517 dimer interface [polypeptide binding]; other site 720555009518 hexamer interface [polypeptide binding]; other site 720555009519 active site 2 [active] 720555009520 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555009521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555009522 dimerization interface [polypeptide binding]; other site 720555009523 putative DNA binding site [nucleotide binding]; other site 720555009524 putative Zn2+ binding site [ion binding]; other site 720555009525 amino acid transporter; Region: 2A0306; TIGR00909 720555009526 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 720555009527 Uncharacterized conserved protein [Function unknown]; Region: COG3465 720555009528 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 720555009529 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 720555009530 Zn2+ binding site [ion binding]; other site 720555009531 Mg2+ binding site [ion binding]; other site 720555009532 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 720555009533 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 720555009534 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 720555009535 EamA-like transporter family; Region: EamA; pfam00892 720555009536 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 720555009537 EamA-like transporter family; Region: EamA; pfam00892 720555009538 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 720555009539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555009540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555009541 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 720555009542 putative dimerization interface [polypeptide binding]; other site 720555009543 Predicted membrane protein [Function unknown]; Region: COG2855 720555009544 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 720555009545 putative heme peroxidase; Provisional; Region: PRK12276 720555009546 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 720555009547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555009548 putative substrate translocation pore; other site 720555009549 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 720555009550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555009551 putative substrate translocation pore; other site 720555009552 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 720555009553 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 720555009554 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 720555009555 NADP binding site [chemical binding]; other site 720555009556 active site 720555009557 putative substrate binding site [chemical binding]; other site 720555009558 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 720555009559 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 720555009560 NAD binding site [chemical binding]; other site 720555009561 substrate binding site [chemical binding]; other site 720555009562 homodimer interface [polypeptide binding]; other site 720555009563 active site 720555009564 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 720555009565 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 720555009566 substrate binding site; other site 720555009567 tetramer interface; other site 720555009568 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 720555009569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555009570 Coenzyme A binding pocket [chemical binding]; other site 720555009571 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 720555009572 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 720555009573 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 720555009574 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 720555009575 active site 720555009576 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 720555009577 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 720555009578 Permease family; Region: Xan_ur_permease; pfam00860 720555009579 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 720555009580 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 720555009581 NAD(P) binding site [chemical binding]; other site 720555009582 catalytic residues [active] 720555009583 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 720555009584 ligand binding site [chemical binding]; other site 720555009585 active site 720555009586 UGI interface [polypeptide binding]; other site 720555009587 catalytic site [active] 720555009588 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 720555009589 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 720555009590 active site 720555009591 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 720555009592 Predicted transcriptional regulators [Transcription]; Region: COG1695 720555009593 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555009594 dimerization interface [polypeptide binding]; other site 720555009595 putative DNA binding site [nucleotide binding]; other site 720555009596 putative Zn2+ binding site [ion binding]; other site 720555009597 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 720555009598 dimer interface [polypeptide binding]; other site 720555009599 substrate binding site [chemical binding]; other site 720555009600 ATP binding site [chemical binding]; other site 720555009601 maltose O-acetyltransferase; Provisional; Region: PRK10092 720555009602 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 720555009603 active site 720555009604 substrate binding site [chemical binding]; other site 720555009605 trimer interface [polypeptide binding]; other site 720555009606 CoA binding site [chemical binding]; other site 720555009607 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 720555009608 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 720555009609 substrate binding [chemical binding]; other site 720555009610 active site 720555009611 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 720555009612 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 720555009613 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 720555009614 active site turn [active] 720555009615 phosphorylation site [posttranslational modification] 720555009616 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 720555009617 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 720555009618 transcriptional antiterminator BglG; Provisional; Region: PRK09772 720555009619 CAT RNA binding domain; Region: CAT_RBD; smart01061 720555009620 PRD domain; Region: PRD; pfam00874 720555009621 PRD domain; Region: PRD; pfam00874 720555009622 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 720555009623 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 720555009624 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 720555009625 putative active site [active] 720555009626 catalytic triad [active] 720555009627 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 720555009628 putative integrin binding motif; other site 720555009629 PA/protease domain interface [polypeptide binding]; other site 720555009630 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 720555009631 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 720555009632 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 720555009633 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 720555009634 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 720555009635 dimer interface [polypeptide binding]; other site 720555009636 FMN binding site [chemical binding]; other site 720555009637 NADPH bind site [chemical binding]; other site 720555009638 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 720555009639 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 720555009640 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 720555009641 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 720555009642 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 720555009643 Subunit I/III interface [polypeptide binding]; other site 720555009644 Subunit III/IV interface [polypeptide binding]; other site 720555009645 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 720555009646 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 720555009647 D-pathway; other site 720555009648 Putative ubiquinol binding site [chemical binding]; other site 720555009649 Low-spin heme (heme b) binding site [chemical binding]; other site 720555009650 Putative water exit pathway; other site 720555009651 Binuclear center (heme o3/CuB) [ion binding]; other site 720555009652 K-pathway; other site 720555009653 Putative proton exit pathway; other site 720555009654 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 720555009655 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 720555009656 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 720555009657 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 720555009658 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 720555009659 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 720555009660 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 720555009661 galactokinase; Provisional; Region: PRK05322 720555009662 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 720555009663 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 720555009664 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 720555009665 Predicted membrane protein [Function unknown]; Region: COG2246 720555009666 GtrA-like protein; Region: GtrA; pfam04138 720555009667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555009668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555009669 Anti-repressor SinI; Region: SinI; pfam08671 720555009670 Methyltransferase domain; Region: Methyltransf_23; pfam13489 720555009671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555009672 S-adenosylmethionine binding site [chemical binding]; other site 720555009673 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 720555009674 Protein of unknown function, DUF485; Region: DUF485; cl01231 720555009675 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 720555009676 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 720555009677 Na binding site [ion binding]; other site 720555009678 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 720555009679 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 720555009680 catalytic residues [active] 720555009681 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 720555009682 thiamine phosphate binding site [chemical binding]; other site 720555009683 active site 720555009684 pyrophosphate binding site [ion binding]; other site 720555009685 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 720555009686 substrate binding site [chemical binding]; other site 720555009687 multimerization interface [polypeptide binding]; other site 720555009688 ATP binding site [chemical binding]; other site 720555009689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555009690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555009691 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 720555009692 putative dimerization interface [polypeptide binding]; other site 720555009693 LrgA family; Region: LrgA; cl00608 720555009694 TIGR00659 family protein; Region: TIGR00659 720555009695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555009696 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 720555009697 Walker A/P-loop; other site 720555009698 ATP binding site [chemical binding]; other site 720555009699 Q-loop/lid; other site 720555009700 ABC transporter signature motif; other site 720555009701 Walker B; other site 720555009702 D-loop; other site 720555009703 H-loop/switch region; other site 720555009704 LrgB-like family; Region: LrgB; cl00596 720555009705 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 720555009706 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 720555009707 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 720555009708 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 720555009709 putative RNA binding site [nucleotide binding]; other site 720555009710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 720555009711 S-adenosylmethionine binding site [chemical binding]; other site 720555009712 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555009713 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 720555009714 active site 720555009715 metal binding site [ion binding]; metal-binding site 720555009716 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 720555009717 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 720555009718 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 720555009719 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 720555009720 active site turn [active] 720555009721 phosphorylation site [posttranslational modification] 720555009722 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 720555009723 transcriptional antiterminator BglG; Provisional; Region: PRK09772 720555009724 CAT RNA binding domain; Region: CAT_RBD; smart01061 720555009725 PRD domain; Region: PRD; pfam00874 720555009726 PRD domain; Region: PRD; pfam00874 720555009727 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 720555009728 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 720555009729 Ligand binding site; other site 720555009730 metal-binding site 720555009731 Predicted integral membrane protein [Function unknown]; Region: COG5522 720555009732 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 720555009733 PA/protease domain interface [polypeptide binding]; other site 720555009734 putative integrin binding motif; other site 720555009735 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 720555009736 Peptidase family M28; Region: Peptidase_M28; pfam04389 720555009737 metal binding site [ion binding]; metal-binding site 720555009738 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555009739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 720555009740 binding surface 720555009741 TPR motif; other site 720555009742 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555009743 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555009744 MarR family; Region: MarR; pfam01047 720555009745 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 720555009746 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 720555009747 active site 720555009748 HIGH motif; other site 720555009749 dimer interface [polypeptide binding]; other site 720555009750 KMSKS motif; other site 720555009751 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 720555009752 RNA binding surface [nucleotide binding]; other site 720555009753 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 720555009754 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 720555009755 synthetase active site [active] 720555009756 NTP binding site [chemical binding]; other site 720555009757 metal binding site [ion binding]; metal-binding site 720555009758 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 720555009759 UbiA prenyltransferase family; Region: UbiA; pfam01040 720555009760 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 720555009761 TrkA-N domain; Region: TrkA_N; pfam02254 720555009762 TrkA-C domain; Region: TrkA_C; pfam02080 720555009763 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 720555009764 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 720555009765 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 720555009766 acyl-activating enzyme (AAE) consensus motif; other site 720555009767 AMP binding site [chemical binding]; other site 720555009768 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 720555009769 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 720555009770 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 720555009771 DltD N-terminal region; Region: DltD_N; pfam04915 720555009772 DltD central region; Region: DltD_M; pfam04918 720555009773 DltD C-terminal region; Region: DltD_C; pfam04914 720555009774 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 720555009775 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 720555009776 homodimer interface [polypeptide binding]; other site 720555009777 substrate-cofactor binding pocket; other site 720555009778 catalytic residue [active] 720555009779 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 720555009780 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 720555009781 NAD binding site [chemical binding]; other site 720555009782 sugar binding site [chemical binding]; other site 720555009783 divalent metal binding site [ion binding]; other site 720555009784 tetramer (dimer of dimers) interface [polypeptide binding]; other site 720555009785 dimer interface [polypeptide binding]; other site 720555009786 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 720555009787 methionine cluster; other site 720555009788 active site 720555009789 phosphorylation site [posttranslational modification] 720555009790 metal binding site [ion binding]; metal-binding site 720555009791 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 720555009792 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 720555009793 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 720555009794 active site 720555009795 P-loop; other site 720555009796 phosphorylation site [posttranslational modification] 720555009797 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 720555009798 HTH domain; Region: HTH_11; pfam08279 720555009799 Mga helix-turn-helix domain; Region: Mga; pfam05043 720555009800 PRD domain; Region: PRD; pfam00874 720555009801 PRD domain; Region: PRD; pfam00874 720555009802 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 720555009803 active site 720555009804 P-loop; other site 720555009805 phosphorylation site [posttranslational modification] 720555009806 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 720555009807 active site 720555009808 phosphorylation site [posttranslational modification] 720555009809 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 720555009810 active site 720555009811 DNA binding site [nucleotide binding] 720555009812 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 720555009813 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 720555009814 tetramer interface [polypeptide binding]; other site 720555009815 heme binding pocket [chemical binding]; other site 720555009816 potential frameshift: common BLAST hit: gi|305676503|ref|YP_003868175.1| putative efflux transporter 720555009817 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 720555009818 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 720555009819 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 720555009820 Walker A/P-loop; other site 720555009821 ATP binding site [chemical binding]; other site 720555009822 Q-loop/lid; other site 720555009823 ABC transporter signature motif; other site 720555009824 Walker B; other site 720555009825 D-loop; other site 720555009826 H-loop/switch region; other site 720555009827 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 720555009828 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 720555009829 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 720555009830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555009831 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555009832 DNA binding residues [nucleotide binding] 720555009833 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 720555009834 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 720555009835 Na binding site [ion binding]; other site 720555009836 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 720555009837 putative substrate binding site [chemical binding]; other site 720555009838 putative ATP binding site [chemical binding]; other site 720555009839 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 720555009840 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 720555009841 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 720555009842 Walker A/P-loop; other site 720555009843 ATP binding site [chemical binding]; other site 720555009844 Q-loop/lid; other site 720555009845 ABC transporter signature motif; other site 720555009846 Walker B; other site 720555009847 D-loop; other site 720555009848 H-loop/switch region; other site 720555009849 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 720555009850 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 720555009851 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 720555009852 Walker A/P-loop; other site 720555009853 ATP binding site [chemical binding]; other site 720555009854 Q-loop/lid; other site 720555009855 ABC transporter signature motif; other site 720555009856 Walker B; other site 720555009857 D-loop; other site 720555009858 H-loop/switch region; other site 720555009859 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 720555009860 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 720555009861 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 720555009862 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 720555009863 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 720555009864 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 720555009865 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 720555009866 putative active site [active] 720555009867 putative metal binding site [ion binding]; other site 720555009868 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 720555009869 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 720555009870 Walker A/P-loop; other site 720555009871 ATP binding site [chemical binding]; other site 720555009872 Q-loop/lid; other site 720555009873 ABC transporter signature motif; other site 720555009874 Walker B; other site 720555009875 D-loop; other site 720555009876 H-loop/switch region; other site 720555009877 TOBE domain; Region: TOBE; pfam03459 720555009878 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 720555009879 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 720555009880 Uncharacterized conserved protein [Function unknown]; Region: COG1284 720555009881 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 720555009882 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 720555009883 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 720555009884 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 720555009885 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 720555009886 UDP-glucose 4-epimerase; Region: PLN02240 720555009887 NAD binding site [chemical binding]; other site 720555009888 homodimer interface [polypeptide binding]; other site 720555009889 active site 720555009890 substrate binding site [chemical binding]; other site 720555009891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 720555009892 Histidine kinase; Region: HisKA_3; pfam07730 720555009893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555009894 ATP binding site [chemical binding]; other site 720555009895 Mg2+ binding site [ion binding]; other site 720555009896 G-X-G motif; other site 720555009897 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 720555009898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555009899 active site 720555009900 phosphorylation site [posttranslational modification] 720555009901 intermolecular recognition site; other site 720555009902 dimerization interface [polypeptide binding]; other site 720555009903 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 720555009904 DNA binding residues [nucleotide binding] 720555009905 dimerization interface [polypeptide binding]; other site 720555009906 peptidase T; Region: peptidase-T; TIGR01882 720555009907 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 720555009908 metal binding site [ion binding]; metal-binding site 720555009909 dimer interface [polypeptide binding]; other site 720555009910 Tubby C 2; Region: Tub_2; cl02043 720555009911 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 720555009912 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 720555009913 active site 720555009914 metal binding site [ion binding]; metal-binding site 720555009915 Y-family of DNA polymerases; Region: PolY; cl12025 720555009916 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 720555009917 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 720555009918 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 720555009919 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 720555009920 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 720555009921 substrate binding site [chemical binding]; other site 720555009922 THF binding site; other site 720555009923 zinc-binding site [ion binding]; other site 720555009924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555009925 putative active site [active] 720555009926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555009927 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 720555009928 Walker A motif; other site 720555009929 ATP binding site [chemical binding]; other site 720555009930 Walker B motif; other site 720555009931 arginine finger; other site 720555009932 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 720555009933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 720555009934 NAD(P) binding site [chemical binding]; other site 720555009935 active site 720555009936 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 720555009937 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 720555009938 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 720555009939 fructuronate transporter; Provisional; Region: PRK10034; cl15264 720555009940 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 720555009941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555009942 S-adenosylmethionine binding site [chemical binding]; other site 720555009943 nucleoside transporter; Region: nupC; TIGR00804 720555009944 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 720555009945 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 720555009946 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 720555009947 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 720555009948 hydroperoxidase II; Provisional; Region: katE; PRK11249 720555009949 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 720555009950 tetramer interface [polypeptide binding]; other site 720555009951 heme binding pocket [chemical binding]; other site 720555009952 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 720555009953 domain interactions; other site 720555009954 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 720555009955 Citrate transporter; Region: CitMHS; pfam03600 720555009956 transcriptional antiterminator BglG; Provisional; Region: PRK09772 720555009957 CAT RNA binding domain; Region: CAT_RBD; smart01061 720555009958 PRD domain; Region: PRD; pfam00874 720555009959 PRD domain; Region: PRD; pfam00874 720555009960 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 720555009961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555009962 putative substrate translocation pore; other site 720555009963 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 720555009964 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 720555009965 ATP binding site [chemical binding]; other site 720555009966 Mg++ binding site [ion binding]; other site 720555009967 motif III; other site 720555009968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555009969 nucleotide binding region [chemical binding]; other site 720555009970 ATP-binding site [chemical binding]; other site 720555009971 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 720555009972 RNA binding site [nucleotide binding]; other site 720555009973 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555009974 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 720555009975 dimer interface [polypeptide binding]; other site 720555009976 substrate binding site [chemical binding]; other site 720555009977 metal binding site [ion binding]; metal-binding site 720555009978 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 720555009979 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 720555009980 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 720555009981 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 720555009982 active site 720555009983 catalytic triad [active] 720555009984 Amb_all domain; Region: Amb_all; smart00656 720555009985 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 720555009986 EamA-like transporter family; Region: EamA; pfam00892 720555009987 EamA-like transporter family; Region: EamA; pfam00892 720555009988 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 720555009989 classical (c) SDRs; Region: SDR_c; cd05233 720555009990 NAD(P) binding site [chemical binding]; other site 720555009991 active site 720555009992 Biofilm formation and stress response factor; Region: BsmA; pfam10014 720555009993 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 720555009994 Ligand Binding Site [chemical binding]; other site 720555009995 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 720555009996 beta-galactosidase; Region: BGL; TIGR03356 720555009997 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 720555009998 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 720555009999 active site turn [active] 720555010000 phosphorylation site [posttranslational modification] 720555010001 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 720555010002 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 720555010003 HPr interaction site; other site 720555010004 glycerol kinase (GK) interaction site [polypeptide binding]; other site 720555010005 active site 720555010006 phosphorylation site [posttranslational modification] 720555010007 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 720555010008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555010009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555010010 homodimer interface [polypeptide binding]; other site 720555010011 catalytic residue [active] 720555010012 Prephenate dehydratase; Region: PDT; pfam00800 720555010013 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 720555010014 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 720555010015 EamA-like transporter family; Region: EamA; pfam00892 720555010016 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 720555010017 EamA-like transporter family; Region: EamA; pfam00892 720555010018 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180 720555010019 PLD-like domain; Region: PLDc_2; pfam13091 720555010020 putative homodimer interface [polypeptide binding]; other site 720555010021 putative active site [active] 720555010022 catalytic site [active] 720555010023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 720555010024 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 720555010025 ATP binding site [chemical binding]; other site 720555010026 putative Mg++ binding site [ion binding]; other site 720555010027 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555010028 nucleotide binding region [chemical binding]; other site 720555010029 ATP-binding site [chemical binding]; other site 720555010030 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 720555010031 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 720555010032 active site 720555010033 8-oxo-dGMP binding site [chemical binding]; other site 720555010034 nudix motif; other site 720555010035 metal binding site [ion binding]; metal-binding site 720555010036 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 720555010037 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 720555010038 substrate binding site [chemical binding]; other site 720555010039 active site 720555010040 anti-terminator HutP; Provisional; Region: hutP; PRK03065 720555010041 RNA binding site [nucleotide binding]; other site 720555010042 hexamer interface [polypeptide binding]; other site 720555010043 Histidine-zinc binding site [chemical binding]; other site 720555010044 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 720555010045 active sites [active] 720555010046 tetramer interface [polypeptide binding]; other site 720555010047 urocanate hydratase; Provisional; Region: PRK05414 720555010048 imidazolonepropionase; Validated; Region: PRK09356 720555010049 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 720555010050 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 720555010051 active site 720555010052 Agmatinase-like family; Region: Agmatinase-like; cd09990 720555010053 agmatinase; Region: agmatinase; TIGR01230 720555010054 active site 720555010055 oligomer interface [polypeptide binding]; other site 720555010056 Mn binding site [ion binding]; other site 720555010057 S-methylmethionine transporter; Provisional; Region: PRK11387 720555010058 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 720555010059 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 720555010060 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 720555010061 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 720555010062 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 720555010063 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 720555010064 Nucleoside recognition; Region: Gate; pfam07670 720555010065 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 720555010066 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 720555010067 intersubunit interface [polypeptide binding]; other site 720555010068 active site 720555010069 catalytic residue [active] 720555010070 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 720555010071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555010072 DNA binding residues [nucleotide binding] 720555010073 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 720555010074 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 720555010075 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 720555010076 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 720555010077 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 720555010078 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 720555010079 nucleotide binding site [chemical binding]; other site 720555010080 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 720555010081 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 720555010082 active site 720555010083 sugar phosphate phosphatase; Provisional; Region: PRK10513 720555010084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555010085 active site 720555010086 motif I; other site 720555010087 motif II; other site 720555010088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555010089 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 720555010090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 720555010091 FtsX-like permease family; Region: FtsX; pfam02687 720555010092 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 720555010093 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 720555010094 Walker A/P-loop; other site 720555010095 ATP binding site [chemical binding]; other site 720555010096 Q-loop/lid; other site 720555010097 ABC transporter signature motif; other site 720555010098 Walker B; other site 720555010099 D-loop; other site 720555010100 H-loop/switch region; other site 720555010101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 720555010102 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 720555010103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555010104 ATP binding site [chemical binding]; other site 720555010105 Mg2+ binding site [ion binding]; other site 720555010106 G-X-G motif; other site 720555010107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555010108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555010109 active site 720555010110 phosphorylation site [posttranslational modification] 720555010111 intermolecular recognition site; other site 720555010112 dimerization interface [polypeptide binding]; other site 720555010113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 720555010114 DNA binding site [nucleotide binding] 720555010115 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 720555010116 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 720555010117 putative ligand binding residues [chemical binding]; other site 720555010118 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 720555010119 intersubunit interface [polypeptide binding]; other site 720555010120 active site 720555010121 zinc binding site [ion binding]; other site 720555010122 Na+ binding site [ion binding]; other site 720555010123 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 720555010124 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 720555010125 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 720555010126 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 720555010127 DNA interaction; other site 720555010128 Metal-binding active site; metal-binding site 720555010129 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 720555010130 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 720555010131 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 720555010132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555010133 putative substrate translocation pore; other site 720555010134 metabolite-proton symporter; Region: 2A0106; TIGR00883 720555010135 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 720555010136 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 720555010137 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 720555010138 PYR/PP interface [polypeptide binding]; other site 720555010139 dimer interface [polypeptide binding]; other site 720555010140 TPP binding site [chemical binding]; other site 720555010141 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 720555010142 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 720555010143 TPP-binding site; other site 720555010144 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 720555010145 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 720555010146 substrate binding site [chemical binding]; other site 720555010147 ATP binding site [chemical binding]; other site 720555010148 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 720555010149 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 720555010150 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 720555010151 tetrameric interface [polypeptide binding]; other site 720555010152 NAD binding site [chemical binding]; other site 720555010153 catalytic residues [active] 720555010154 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 720555010155 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 720555010156 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 720555010157 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 720555010158 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 720555010159 active site 720555010160 catalytic tetrad [active] 720555010161 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 720555010162 CGNR zinc finger; Region: zf-CGNR; pfam11706 720555010163 HPP family; Region: HPP; pfam04982 720555010164 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 720555010165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555010166 putative substrate translocation pore; other site 720555010167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555010168 heat shock protein 90; Provisional; Region: PRK05218 720555010169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555010170 ATP binding site [chemical binding]; other site 720555010171 Mg2+ binding site [ion binding]; other site 720555010172 G-X-G motif; other site 720555010173 short chain dehydrogenase; Validated; Region: PRK08589 720555010174 classical (c) SDRs; Region: SDR_c; cd05233 720555010175 NAD(P) binding site [chemical binding]; other site 720555010176 active site 720555010177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555010178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555010179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555010180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555010181 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 720555010182 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 720555010183 NAD(P) binding site [chemical binding]; other site 720555010184 catalytic residues [active] 720555010185 RDD family; Region: RDD; pfam06271 720555010186 Predicted membrane protein [Function unknown]; Region: COG2311 720555010187 Protein of unknown function (DUF418); Region: DUF418; cl12135 720555010188 Protein of unknown function (DUF418); Region: DUF418; pfam04235 720555010189 Cupin domain; Region: Cupin_2; pfam07883 720555010190 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 720555010191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555010192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555010193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555010194 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 720555010195 active site 720555010196 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 720555010197 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 720555010198 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 720555010199 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 720555010200 fructuronate transporter; Provisional; Region: PRK10034; cl15264 720555010201 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 720555010202 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 720555010203 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 720555010204 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 720555010205 Transcriptional regulators [Transcription]; Region: GntR; COG1802 720555010206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555010207 DNA-binding site [nucleotide binding]; DNA binding site 720555010208 FCD domain; Region: FCD; pfam07729 720555010209 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 720555010210 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 720555010211 N- and C-terminal domain interface [polypeptide binding]; other site 720555010212 active site 720555010213 catalytic site [active] 720555010214 metal binding site [ion binding]; metal-binding site 720555010215 carbohydrate binding site [chemical binding]; other site 720555010216 ATP binding site [chemical binding]; other site 720555010217 fructuronate transporter; Provisional; Region: PRK10034; cl15264 720555010218 gluconate transporter; Region: gntP; TIGR00791 720555010219 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 720555010220 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 720555010221 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 720555010222 peroxiredoxin; Region: AhpC; TIGR03137 720555010223 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 720555010224 dimer interface [polypeptide binding]; other site 720555010225 decamer (pentamer of dimers) interface [polypeptide binding]; other site 720555010226 catalytic triad [active] 720555010227 peroxidatic and resolving cysteines [active] 720555010228 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 720555010229 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 720555010230 catalytic residue [active] 720555010231 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 720555010232 catalytic residues [active] 720555010233 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 720555010234 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555010235 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 720555010236 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 720555010237 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 720555010238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555010239 Walker A/P-loop; other site 720555010240 ATP binding site [chemical binding]; other site 720555010241 Q-loop/lid; other site 720555010242 ABC transporter signature motif; other site 720555010243 Walker B; other site 720555010244 D-loop; other site 720555010245 H-loop/switch region; other site 720555010246 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 720555010247 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 720555010248 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 720555010249 catalytic nucleophile [active] 720555010250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555010251 non-specific DNA binding site [nucleotide binding]; other site 720555010252 salt bridge; other site 720555010253 sequence-specific DNA binding site [nucleotide binding]; other site 720555010254 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 720555010255 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 720555010256 DNA methylase; Region: N6_N4_Mtase; pfam01555 720555010257 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 720555010258 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 720555010259 PLD-like domain; Region: PLDc_2; pfam13091 720555010260 putative homodimer interface [polypeptide binding]; other site 720555010261 putative active site [active] 720555010262 catalytic site [active] 720555010263 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 720555010264 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 720555010265 catalytic residues [active] 720555010266 catalytic nucleophile [active] 720555010267 Recombinase; Region: Recombinase; pfam07508 720555010268 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 720555010269 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 720555010270 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 720555010271 catalytic residues [active] 720555010272 catalytic nucleophile [active] 720555010273 D5 N terminal like; Region: D5_N; smart00885 720555010274 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 720555010275 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 720555010276 DNA methylase; Region: N6_N4_Mtase; cl17433 720555010277 DNA methylase; Region: N6_N4_Mtase; pfam01555 720555010278 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 720555010279 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 720555010280 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 720555010281 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 720555010282 NAD binding site [chemical binding]; other site 720555010283 catalytic Zn binding site [ion binding]; other site 720555010284 structural Zn binding site [ion binding]; other site 720555010285 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 720555010286 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 720555010287 Arginase family; Region: Arginase; cd09989 720555010288 agmatinase; Region: agmatinase; TIGR01230 720555010289 active site 720555010290 Mn binding site [ion binding]; other site 720555010291 oligomer interface [polypeptide binding]; other site 720555010292 S-methylmethionine transporter; Provisional; Region: PRK11387 720555010293 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 720555010294 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 720555010295 inhibitor-cofactor binding pocket; inhibition site 720555010296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555010297 catalytic residue [active] 720555010298 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 720555010299 Predicted integral membrane protein [Function unknown]; Region: COG5658 720555010300 SdpI/YhfL protein family; Region: SdpI; pfam13630 720555010301 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555010302 dimerization interface [polypeptide binding]; other site 720555010303 putative DNA binding site [nucleotide binding]; other site 720555010304 putative Zn2+ binding site [ion binding]; other site 720555010305 PAS domain; Region: PAS_9; pfam13426 720555010306 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 720555010307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555010308 Walker A motif; other site 720555010309 ATP binding site [chemical binding]; other site 720555010310 Walker B motif; other site 720555010311 arginine finger; other site 720555010312 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 720555010313 Cupin-like domain; Region: Cupin_8; pfam13621 720555010314 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 720555010315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555010316 Walker A/P-loop; other site 720555010317 ATP binding site [chemical binding]; other site 720555010318 Q-loop/lid; other site 720555010319 ABC transporter signature motif; other site 720555010320 Walker B; other site 720555010321 D-loop; other site 720555010322 H-loop/switch region; other site 720555010323 ABC transporter; Region: ABC_tran_2; pfam12848 720555010324 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 720555010325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555010326 putative substrate translocation pore; other site 720555010327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555010328 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 720555010329 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 720555010330 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 720555010331 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 720555010332 ATP binding site [chemical binding]; other site 720555010333 substrate interface [chemical binding]; other site 720555010334 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 720555010335 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 720555010336 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 720555010337 protein binding site [polypeptide binding]; other site 720555010338 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 720555010339 YycH protein; Region: YycI; cl02015 720555010340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 720555010341 YycH protein; Region: YycH; pfam07435 720555010342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 720555010343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 720555010344 dimerization interface [polypeptide binding]; other site 720555010345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555010346 putative active site [active] 720555010347 heme pocket [chemical binding]; other site 720555010348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555010349 dimer interface [polypeptide binding]; other site 720555010350 phosphorylation site [posttranslational modification] 720555010351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555010352 ATP binding site [chemical binding]; other site 720555010353 Mg2+ binding site [ion binding]; other site 720555010354 G-X-G motif; other site 720555010355 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555010356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555010357 active site 720555010358 phosphorylation site [posttranslational modification] 720555010359 intermolecular recognition site; other site 720555010360 dimerization interface [polypeptide binding]; other site 720555010361 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 720555010362 DNA binding site [nucleotide binding] 720555010363 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 720555010364 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 720555010365 GDP-binding site [chemical binding]; other site 720555010366 ACT binding site; other site 720555010367 IMP binding site; other site 720555010368 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555010369 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 720555010370 active site 720555010371 replicative DNA helicase; Provisional; Region: PRK05748 720555010372 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 720555010373 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 720555010374 Walker A motif; other site 720555010375 ATP binding site [chemical binding]; other site 720555010376 Walker B motif; other site 720555010377 DNA binding loops [nucleotide binding] 720555010378 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 720555010379 YycC-like protein; Region: YycC; pfam14174 720555010380 cyanate transporter; Region: CynX; TIGR00896 720555010381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555010382 putative substrate translocation pore; other site 720555010383 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 720555010384 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 720555010385 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 720555010386 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 720555010387 diguanylate cyclase; Region: GGDEF; smart00267 720555010388 DHH family; Region: DHH; pfam01368 720555010389 DHHA1 domain; Region: DHHA1; pfam02272 720555010390 Predicted membrane protein [Function unknown]; Region: COG4241 720555010391 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 720555010392 Predicted transcriptional regulators [Transcription]; Region: COG1733 720555010393 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 720555010394 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 720555010395 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 720555010396 DHHA2 domain; Region: DHHA2; pfam02833 720555010397 D-galactonate transporter; Region: 2A0114; TIGR00893 720555010398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555010399 putative substrate translocation pore; other site 720555010400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 720555010401 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 720555010402 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 720555010403 tartrate dehydrogenase; Provisional; Region: PRK08194 720555010404 Transcriptional regulators [Transcription]; Region: FadR; COG2186 720555010405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555010406 DNA-binding site [nucleotide binding]; DNA binding site 720555010407 FCD domain; Region: FCD; pfam07729 720555010408 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 720555010409 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 720555010410 DNA binding residues [nucleotide binding] 720555010411 dimer interface [polypeptide binding]; other site 720555010412 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 720555010413 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555010414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555010415 active site 720555010416 phosphorylation site [posttranslational modification] 720555010417 intermolecular recognition site; other site 720555010418 dimerization interface [polypeptide binding]; other site 720555010419 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 720555010420 DNA binding site [nucleotide binding] 720555010421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 720555010422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555010423 dimer interface [polypeptide binding]; other site 720555010424 phosphorylation site [posttranslational modification] 720555010425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555010426 ATP binding site [chemical binding]; other site 720555010427 Mg2+ binding site [ion binding]; other site 720555010428 G-X-G motif; other site 720555010429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555010430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555010431 putative substrate translocation pore; other site 720555010432 DsrE/DsrF-like family; Region: DrsE; cl00672 720555010433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555010434 dimerization interface [polypeptide binding]; other site 720555010435 putative DNA binding site [nucleotide binding]; other site 720555010436 putative Zn2+ binding site [ion binding]; other site 720555010437 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 720555010438 active site residue [active] 720555010439 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 720555010440 dihydrodipicolinate synthase; Region: dapA; TIGR00674 720555010441 inhibitor site; inhibition site 720555010442 active site 720555010443 dimer interface [polypeptide binding]; other site 720555010444 catalytic residue [active] 720555010445 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 720555010446 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 720555010447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555010448 DNA-binding site [nucleotide binding]; DNA binding site 720555010449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555010450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555010451 homodimer interface [polypeptide binding]; other site 720555010452 catalytic residue [active] 720555010453 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 720555010454 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 720555010455 catalytic residues [active] 720555010456 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 720555010457 benzoate transport; Region: 2A0115; TIGR00895 720555010458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555010459 putative substrate translocation pore; other site 720555010460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555010461 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 720555010462 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555010463 putative metal binding site [ion binding]; other site 720555010464 Transcriptional regulators [Transcription]; Region: PurR; COG1609 720555010465 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 720555010466 DNA binding site [nucleotide binding] 720555010467 domain linker motif; other site 720555010468 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 720555010469 putative dimerization interface [polypeptide binding]; other site 720555010470 putative ligand binding site [chemical binding]; other site 720555010471 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 720555010472 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 720555010473 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 720555010474 DNA binding site [nucleotide binding] 720555010475 active site 720555010476 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 720555010477 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 720555010478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 720555010479 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 720555010480 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 720555010481 active site 720555010482 putative catalytic site [active] 720555010483 DNA binding site [nucleotide binding] 720555010484 putative phosphate binding site [ion binding]; other site 720555010485 metal binding site A [ion binding]; metal-binding site 720555010486 AP binding site [nucleotide binding]; other site 720555010487 metal binding site B [ion binding]; metal-binding site 720555010488 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 720555010489 EamA-like transporter family; Region: EamA; pfam00892 720555010490 EamA-like transporter family; Region: EamA; pfam00892 720555010491 Transcriptional regulators [Transcription]; Region: GntR; COG1802 720555010492 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555010493 DNA-binding site [nucleotide binding]; DNA binding site 720555010494 FCD domain; Region: FCD; pfam07729 720555010495 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 720555010496 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 720555010497 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 720555010498 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 720555010499 dimer interface [polypeptide binding]; other site 720555010500 ssDNA binding site [nucleotide binding]; other site 720555010501 tetramer (dimer of dimers) interface [polypeptide binding]; other site 720555010502 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 720555010503 GTP-binding protein YchF; Reviewed; Region: PRK09601 720555010504 YchF GTPase; Region: YchF; cd01900 720555010505 G1 box; other site 720555010506 GTP/Mg2+ binding site [chemical binding]; other site 720555010507 Switch I region; other site 720555010508 G2 box; other site 720555010509 Switch II region; other site 720555010510 G3 box; other site 720555010511 G4 box; other site 720555010512 G5 box; other site 720555010513 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 720555010514 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 720555010515 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 720555010516 putative [4Fe-4S] binding site [ion binding]; other site 720555010517 putative molybdopterin cofactor binding site [chemical binding]; other site 720555010518 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 720555010519 molybdopterin cofactor binding site; other site 720555010520 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 720555010521 Uncharacterized membrane protein [Function unknown]; Region: COG3949 720555010522 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 720555010523 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 720555010524 ParB-like nuclease domain; Region: ParB; smart00470 720555010525 KorB domain; Region: KorB; pfam08535 720555010526 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 720555010527 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 720555010528 P-loop; other site 720555010529 Magnesium ion binding site [ion binding]; other site 720555010530 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 720555010531 Magnesium ion binding site [ion binding]; other site 720555010532 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 720555010533 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 720555010534 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 720555010535 ParB-like nuclease domain; Region: ParB; smart00470 720555010536 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 720555010537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555010538 S-adenosylmethionine binding site [chemical binding]; other site 720555010539 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 720555010540 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 720555010541 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 720555010542 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 720555010543 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 720555010544 trmE is a tRNA modification GTPase; Region: trmE; cd04164 720555010545 G1 box; other site 720555010546 GTP/Mg2+ binding site [chemical binding]; other site 720555010547 Switch I region; other site 720555010548 G2 box; other site 720555010549 Switch II region; other site 720555010550 G3 box; other site 720555010551 G4 box; other site 720555010552 G5 box; other site 720555010553 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 720555010554 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 720555010555 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 720555010556 G-X-X-G motif; other site 720555010557 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 720555010558 RxxxH motif; other site 720555010559 OxaA-like protein precursor; Validated; Region: PRK02944 720555010560 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 720555010561 ribonuclease P; Reviewed; Region: rnpA; PRK00499 720555010562 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 720555010563 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 720555010564 DnaA N-terminal domain; Region: DnaA_N; pfam11638 720555010565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555010566 Walker A motif; other site 720555010567 ATP binding site [chemical binding]; other site 720555010568 Walker B motif; other site 720555010569 arginine finger; other site 720555010570 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 720555010571 DnaA box-binding interface [nucleotide binding]; other site 720555010572 DNA polymerase III subunit beta; Validated; Region: PRK05643 720555010573 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 720555010574 putative DNA binding surface [nucleotide binding]; other site 720555010575 dimer interface [polypeptide binding]; other site 720555010576 beta-clamp/clamp loader binding surface; other site 720555010577 beta-clamp/translesion DNA polymerase binding surface; other site 720555010578 S4 domain; Region: S4_2; pfam13275 720555010579 recombination protein F; Reviewed; Region: recF; PRK00064 720555010580 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 720555010581 Walker A/P-loop; other site 720555010582 ATP binding site [chemical binding]; other site 720555010583 Q-loop/lid; other site 720555010584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555010585 ABC transporter signature motif; other site 720555010586 Walker B; other site 720555010587 D-loop; other site 720555010588 H-loop/switch region; other site 720555010589 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 720555010590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555010591 ATP binding site [chemical binding]; other site 720555010592 Mg2+ binding site [ion binding]; other site 720555010593 G-X-G motif; other site 720555010594 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 720555010595 anchoring element; other site 720555010596 dimer interface [polypeptide binding]; other site 720555010597 ATP binding site [chemical binding]; other site 720555010598 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 720555010599 active site 720555010600 putative metal-binding site [ion binding]; other site 720555010601 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 720555010602 DNA gyrase subunit A; Validated; Region: PRK05560 720555010603 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 720555010604 CAP-like domain; other site 720555010605 active site 720555010606 primary dimer interface [polypeptide binding]; other site 720555010607 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 720555010608 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 720555010609 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 720555010610 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 720555010611 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 720555010612 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 720555010613 YaaC-like Protein; Region: YaaC; pfam14175 720555010614 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 720555010615 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 720555010616 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 720555010617 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 720555010618 active site 720555010619 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 720555010620 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 720555010621 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 720555010622 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 720555010623 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 720555010624 active site 720555010625 multimer interface [polypeptide binding]; other site 720555010626 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 720555010627 Glutamine amidotransferase class-I; Region: GATase; pfam00117 720555010628 predicted active site [active] 720555010629 catalytic triad [active] 720555010630 seryl-tRNA synthetase; Provisional; Region: PRK05431 720555010631 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 720555010632 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 720555010633 dimer interface [polypeptide binding]; other site 720555010634 active site 720555010635 motif 1; other site 720555010636 motif 2; other site 720555010637 motif 3; other site 720555010638 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 720555010639 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 720555010640 Substrate-binding site [chemical binding]; other site 720555010641 Substrate specificity [chemical binding]; other site 720555010642 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 720555010643 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 720555010644 Substrate-binding site [chemical binding]; other site 720555010645 Substrate specificity [chemical binding]; other site 720555010646 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 720555010647 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555010648 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 720555010649 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 720555010650 active site 720555010651 Isochorismatase family; Region: Isochorismatase; pfam00857 720555010652 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 720555010653 catalytic triad [active] 720555010654 conserved cis-peptide bond; other site 720555010655 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 720555010656 nucleoside/Zn binding site; other site 720555010657 dimer interface [polypeptide binding]; other site 720555010658 catalytic motif [active] 720555010659 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 720555010660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555010661 Walker A motif; other site 720555010662 ATP binding site [chemical binding]; other site 720555010663 Walker B motif; other site 720555010664 arginine finger; other site 720555010665 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 720555010666 hypothetical protein; Validated; Region: PRK00153 720555010667 recombination protein RecR; Reviewed; Region: recR; PRK00076 720555010668 RecR protein; Region: RecR; pfam02132 720555010669 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 720555010670 putative active site [active] 720555010671 putative metal-binding site [ion binding]; other site 720555010672 tetramer interface [polypeptide binding]; other site 720555010673 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 720555010674 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 720555010675 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 720555010676 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 720555010677 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 720555010678 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 720555010679 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 720555010680 homodimer interface [polypeptide binding]; other site 720555010681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555010682 catalytic residue [active] 720555010683 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 720555010684 thymidylate kinase; Validated; Region: tmk; PRK00698 720555010685 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 720555010686 TMP-binding site; other site 720555010687 ATP-binding site [chemical binding]; other site 720555010688 Protein of unknown function (DUF970); Region: DUF970; pfam06153 720555010689 Protein of unknown function (DUF327); Region: DUF327; pfam03885 720555010690 DNA polymerase III subunit delta'; Validated; Region: PRK08058 720555010691 DNA polymerase III subunit delta'; Validated; Region: PRK08485 720555010692 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 720555010693 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 720555010694 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 720555010695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555010696 S-adenosylmethionine binding site [chemical binding]; other site 720555010697 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 720555010698 GIY-YIG motif/motif A; other site 720555010699 putative active site [active] 720555010700 putative metal binding site [ion binding]; other site 720555010701 Predicted methyltransferases [General function prediction only]; Region: COG0313 720555010702 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 720555010703 putative SAM binding site [chemical binding]; other site 720555010704 putative homodimer interface [polypeptide binding]; other site 720555010705 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 720555010706 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 720555010707 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 720555010708 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 720555010709 active site 720555010710 HIGH motif; other site 720555010711 KMSKS motif; other site 720555010712 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 720555010713 tRNA binding surface [nucleotide binding]; other site 720555010714 anticodon binding site; other site 720555010715 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 720555010716 dimer interface [polypeptide binding]; other site 720555010717 putative tRNA-binding site [nucleotide binding]; other site 720555010718 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 720555010719 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 720555010720 active site 720555010721 Domain of unknown function (DUF348); Region: DUF348; pfam03990 720555010722 Domain of unknown function (DUF348); Region: DUF348; pfam03990 720555010723 Domain of unknown function (DUF348); Region: DUF348; pfam03990 720555010724 G5 domain; Region: G5; pfam07501 720555010725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 720555010726 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 720555010727 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 720555010728 putative active site [active] 720555010729 putative metal binding site [ion binding]; other site 720555010730 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 720555010731 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 720555010732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555010733 S-adenosylmethionine binding site [chemical binding]; other site 720555010734 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 720555010735 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 720555010736 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 720555010737 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 720555010738 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 720555010739 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 720555010740 pur operon repressor; Provisional; Region: PRK09213 720555010741 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 720555010742 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 720555010743 active site 720555010744 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 720555010745 homotrimer interaction site [polypeptide binding]; other site 720555010746 putative active site [active] 720555010747 regulatory protein SpoVG; Reviewed; Region: PRK13259 720555010748 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 720555010749 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 720555010750 Substrate binding site; other site 720555010751 Mg++ binding site; other site 720555010752 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 720555010753 active site 720555010754 substrate binding site [chemical binding]; other site 720555010755 CoA binding site [chemical binding]; other site 720555010756 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 720555010757 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 720555010758 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 720555010759 active site 720555010760 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 720555010761 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 720555010762 5S rRNA interface [nucleotide binding]; other site 720555010763 CTC domain interface [polypeptide binding]; other site 720555010764 L16 interface [polypeptide binding]; other site 720555010765 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 720555010766 putative active site [active] 720555010767 catalytic residue [active] 720555010768 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 720555010769 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 720555010770 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 720555010771 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 720555010772 ATP binding site [chemical binding]; other site 720555010773 putative Mg++ binding site [ion binding]; other site 720555010774 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555010775 nucleotide binding region [chemical binding]; other site 720555010776 ATP-binding site [chemical binding]; other site 720555010777 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 720555010778 stage V sporulation protein T; Region: spore_V_T; TIGR02851 720555010779 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 720555010780 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 720555010781 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 720555010782 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 720555010783 putative SAM binding site [chemical binding]; other site 720555010784 putative homodimer interface [polypeptide binding]; other site 720555010785 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 720555010786 homodimer interface [polypeptide binding]; other site 720555010787 metal binding site [ion binding]; metal-binding site 720555010788 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 720555010789 homodimer interface [polypeptide binding]; other site 720555010790 active site 720555010791 putative chemical substrate binding site [chemical binding]; other site 720555010792 metal binding site [ion binding]; metal-binding site 720555010793 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 720555010794 RNA binding surface [nucleotide binding]; other site 720555010795 sporulation protein YabP; Region: spore_yabP; TIGR02892 720555010796 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 720555010797 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 720555010798 Septum formation initiator; Region: DivIC; pfam04977 720555010799 hypothetical protein; Provisional; Region: PRK08582 720555010800 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 720555010801 RNA binding site [nucleotide binding]; other site 720555010802 stage II sporulation protein E; Region: spore_II_E; TIGR02865 720555010803 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 720555010804 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 720555010805 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 720555010806 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 720555010807 metal ion-dependent adhesion site (MIDAS); other site 720555010808 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 720555010809 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 720555010810 active site 720555010811 ATP binding site [chemical binding]; other site 720555010812 substrate binding site [chemical binding]; other site 720555010813 activation loop (A-loop); other site 720555010814 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 720555010815 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 720555010816 Ligand Binding Site [chemical binding]; other site 720555010817 TilS substrate binding domain; Region: TilS; pfam09179 720555010818 TilS substrate C-terminal domain; Region: TilS_C; smart00977 720555010819 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 720555010820 active site 720555010821 FtsH Extracellular; Region: FtsH_ext; pfam06480 720555010822 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 720555010823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555010824 Walker A motif; other site 720555010825 ATP binding site [chemical binding]; other site 720555010826 Walker B motif; other site 720555010827 arginine finger; other site 720555010828 Peptidase family M41; Region: Peptidase_M41; pfam01434 720555010829 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 720555010830 nucleotide binding site [chemical binding]; other site 720555010831 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 720555010832 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 720555010833 dimerization interface [polypeptide binding]; other site 720555010834 domain crossover interface; other site 720555010835 redox-dependent activation switch; other site 720555010836 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 720555010837 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 720555010838 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 720555010839 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 720555010840 dimer interface [polypeptide binding]; other site 720555010841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555010842 catalytic residue [active] 720555010843 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 720555010844 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 720555010845 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 720555010846 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 720555010847 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 720555010848 glutamine binding [chemical binding]; other site 720555010849 catalytic triad [active] 720555010850 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 720555010851 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 720555010852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555010853 catalytic residue [active] 720555010854 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 720555010855 dihydropteroate synthase; Region: DHPS; TIGR01496 720555010856 substrate binding pocket [chemical binding]; other site 720555010857 dimer interface [polypeptide binding]; other site 720555010858 inhibitor binding site; inhibition site 720555010859 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 720555010860 homooctamer interface [polypeptide binding]; other site 720555010861 active site 720555010862 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 720555010863 catalytic center binding site [active] 720555010864 ATP binding site [chemical binding]; other site 720555010865 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 720555010866 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555010867 non-specific DNA binding site [nucleotide binding]; other site 720555010868 salt bridge; other site 720555010869 sequence-specific DNA binding site [nucleotide binding]; other site 720555010870 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 720555010871 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 720555010872 FMN binding site [chemical binding]; other site 720555010873 active site 720555010874 catalytic residues [active] 720555010875 substrate binding site [chemical binding]; other site 720555010876 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 720555010877 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 720555010878 dimer interface [polypeptide binding]; other site 720555010879 putative anticodon binding site; other site 720555010880 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 720555010881 motif 1; other site 720555010882 active site 720555010883 motif 2; other site 720555010884 motif 3; other site 720555010885 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 720555010886 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 720555010887 UvrB/uvrC motif; Region: UVR; pfam02151 720555010888 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 720555010889 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 720555010890 ADP binding site [chemical binding]; other site 720555010891 phosphagen binding site; other site 720555010892 substrate specificity loop; other site 720555010893 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 720555010894 Clp amino terminal domain; Region: Clp_N; pfam02861 720555010895 Clp amino terminal domain; Region: Clp_N; pfam02861 720555010896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555010897 Walker A motif; other site 720555010898 ATP binding site [chemical binding]; other site 720555010899 Walker B motif; other site 720555010900 arginine finger; other site 720555010901 UvrB/uvrC motif; Region: UVR; pfam02151 720555010902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 720555010903 Walker A motif; other site 720555010904 ATP binding site [chemical binding]; other site 720555010905 Walker B motif; other site 720555010906 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 720555010907 DNA repair protein RadA; Provisional; Region: PRK11823 720555010908 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 720555010909 Walker A motif/ATP binding site; other site 720555010910 ATP binding site [chemical binding]; other site 720555010911 Walker B motif; other site 720555010912 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 720555010913 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 720555010914 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 720555010915 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 720555010916 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 720555010917 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 720555010918 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 720555010919 putative active site [active] 720555010920 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 720555010921 substrate binding site; other site 720555010922 dimer interface; other site 720555010923 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 720555010924 homotrimer interaction site [polypeptide binding]; other site 720555010925 zinc binding site [ion binding]; other site 720555010926 CDP-binding sites; other site 720555010927 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 720555010928 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 720555010929 HIGH motif; other site 720555010930 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 720555010931 active site 720555010932 KMSKS motif; other site 720555010933 serine O-acetyltransferase; Region: cysE; TIGR01172 720555010934 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 720555010935 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 720555010936 trimer interface [polypeptide binding]; other site 720555010937 active site 720555010938 substrate binding site [chemical binding]; other site 720555010939 CoA binding site [chemical binding]; other site 720555010940 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 720555010941 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 720555010942 active site 720555010943 HIGH motif; other site 720555010944 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 720555010945 KMSKS motif; other site 720555010946 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 720555010947 tRNA binding surface [nucleotide binding]; other site 720555010948 anticodon binding site; other site 720555010949 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 720555010950 active site 720555010951 metal binding site [ion binding]; metal-binding site 720555010952 dimerization interface [polypeptide binding]; other site 720555010953 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 720555010954 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 720555010955 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 720555010956 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 720555010957 RNA polymerase factor sigma-70; Validated; Region: PRK08295 720555010958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555010959 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 720555010960 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 720555010961 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 720555010962 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 720555010963 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 720555010964 putative homodimer interface [polypeptide binding]; other site 720555010965 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 720555010966 heterodimer interface [polypeptide binding]; other site 720555010967 homodimer interface [polypeptide binding]; other site 720555010968 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 720555010969 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 720555010970 23S rRNA interface [nucleotide binding]; other site 720555010971 L7/L12 interface [polypeptide binding]; other site 720555010972 putative thiostrepton binding site; other site 720555010973 L25 interface [polypeptide binding]; other site 720555010974 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 720555010975 mRNA/rRNA interface [nucleotide binding]; other site 720555010976 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 720555010977 23S rRNA interface [nucleotide binding]; other site 720555010978 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 720555010979 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 720555010980 core dimer interface [polypeptide binding]; other site 720555010981 peripheral dimer interface [polypeptide binding]; other site 720555010982 L10 interface [polypeptide binding]; other site 720555010983 L11 interface [polypeptide binding]; other site 720555010984 putative EF-Tu interaction site [polypeptide binding]; other site 720555010985 putative EF-G interaction site [polypeptide binding]; other site 720555010986 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 720555010987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555010988 S-adenosylmethionine binding site [chemical binding]; other site 720555010989 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 720555010990 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 720555010991 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 720555010992 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 720555010993 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 720555010994 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 720555010995 RPB1 interaction site [polypeptide binding]; other site 720555010996 RPB10 interaction site [polypeptide binding]; other site 720555010997 RPB11 interaction site [polypeptide binding]; other site 720555010998 RPB3 interaction site [polypeptide binding]; other site 720555010999 RPB12 interaction site [polypeptide binding]; other site 720555011000 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 720555011001 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 720555011002 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 720555011003 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 720555011004 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 720555011005 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 720555011006 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 720555011007 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 720555011008 G-loop; other site 720555011009 DNA binding site [nucleotide binding] 720555011010 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 720555011011 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 720555011012 S17 interaction site [polypeptide binding]; other site 720555011013 S8 interaction site; other site 720555011014 16S rRNA interaction site [nucleotide binding]; other site 720555011015 streptomycin interaction site [chemical binding]; other site 720555011016 23S rRNA interaction site [nucleotide binding]; other site 720555011017 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 720555011018 30S ribosomal protein S7; Validated; Region: PRK05302 720555011019 elongation factor G; Reviewed; Region: PRK00007 720555011020 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 720555011021 G1 box; other site 720555011022 putative GEF interaction site [polypeptide binding]; other site 720555011023 GTP/Mg2+ binding site [chemical binding]; other site 720555011024 Switch I region; other site 720555011025 G2 box; other site 720555011026 G3 box; other site 720555011027 Switch II region; other site 720555011028 G4 box; other site 720555011029 G5 box; other site 720555011030 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 720555011031 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 720555011032 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 720555011033 elongation factor Tu; Reviewed; Region: PRK00049 720555011034 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 720555011035 G1 box; other site 720555011036 GEF interaction site [polypeptide binding]; other site 720555011037 GTP/Mg2+ binding site [chemical binding]; other site 720555011038 Switch I region; other site 720555011039 G2 box; other site 720555011040 G3 box; other site 720555011041 Switch II region; other site 720555011042 G4 box; other site 720555011043 G5 box; other site 720555011044 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 720555011045 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 720555011046 Antibiotic Binding Site [chemical binding]; other site 720555011047 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 720555011048 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 720555011049 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 720555011050 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 720555011051 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 720555011052 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 720555011053 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 720555011054 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 720555011055 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 720555011056 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 720555011057 putative translocon binding site; other site 720555011058 protein-rRNA interface [nucleotide binding]; other site 720555011059 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 720555011060 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 720555011061 G-X-X-G motif; other site 720555011062 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 720555011063 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 720555011064 23S rRNA interface [nucleotide binding]; other site 720555011065 5S rRNA interface [nucleotide binding]; other site 720555011066 putative antibiotic binding site [chemical binding]; other site 720555011067 L25 interface [polypeptide binding]; other site 720555011068 L27 interface [polypeptide binding]; other site 720555011069 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 720555011070 23S rRNA interface [nucleotide binding]; other site 720555011071 putative translocon interaction site; other site 720555011072 signal recognition particle (SRP54) interaction site; other site 720555011073 L23 interface [polypeptide binding]; other site 720555011074 trigger factor interaction site; other site 720555011075 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 720555011076 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 720555011077 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 720555011078 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 720555011079 RNA binding site [nucleotide binding]; other site 720555011080 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 720555011081 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 720555011082 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 720555011083 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 720555011084 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 720555011085 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 720555011086 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 720555011087 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 720555011088 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 720555011089 5S rRNA interface [nucleotide binding]; other site 720555011090 L27 interface [polypeptide binding]; other site 720555011091 23S rRNA interface [nucleotide binding]; other site 720555011092 L5 interface [polypeptide binding]; other site 720555011093 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 720555011094 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 720555011095 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 720555011096 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 720555011097 23S rRNA binding site [nucleotide binding]; other site 720555011098 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 720555011099 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 720555011100 SecY translocase; Region: SecY; pfam00344 720555011101 adenylate kinase; Reviewed; Region: adk; PRK00279 720555011102 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 720555011103 AMP-binding site [chemical binding]; other site 720555011104 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 720555011105 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 720555011106 active site 720555011107 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 720555011108 RNA binding site [nucleotide binding]; other site 720555011109 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 720555011110 rRNA binding site [nucleotide binding]; other site 720555011111 predicted 30S ribosome binding site; other site 720555011112 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 720555011113 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 720555011114 30S ribosomal protein S13; Region: bact_S13; TIGR03631 720555011115 30S ribosomal protein S11; Validated; Region: PRK05309 720555011116 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 720555011117 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 720555011118 alphaNTD homodimer interface [polypeptide binding]; other site 720555011119 alphaNTD - beta interaction site [polypeptide binding]; other site 720555011120 alphaNTD - beta' interaction site [polypeptide binding]; other site 720555011121 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 720555011122 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 720555011123 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 720555011124 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 720555011125 Walker A/P-loop; other site 720555011126 ATP binding site [chemical binding]; other site 720555011127 Q-loop/lid; other site 720555011128 ABC transporter signature motif; other site 720555011129 Walker B; other site 720555011130 D-loop; other site 720555011131 H-loop/switch region; other site 720555011132 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 720555011133 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 720555011134 Walker A/P-loop; other site 720555011135 ATP binding site [chemical binding]; other site 720555011136 Q-loop/lid; other site 720555011137 ABC transporter signature motif; other site 720555011138 Walker B; other site 720555011139 D-loop; other site 720555011140 H-loop/switch region; other site 720555011141 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 720555011142 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 720555011143 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 720555011144 dimerization interface 3.5A [polypeptide binding]; other site 720555011145 active site 720555011146 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 720555011147 23S rRNA interface [nucleotide binding]; other site 720555011148 L3 interface [polypeptide binding]; other site 720555011149 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 720555011150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555011151 S-adenosylmethionine binding site [chemical binding]; other site 720555011152 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 720555011153 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 720555011154 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 720555011155 active site 720555011156 metal binding site [ion binding]; metal-binding site 720555011157 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 720555011158 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 720555011159 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 720555011160 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 720555011161 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 720555011162 potential protein location (hypothetical protein BATR1942_19405 [Bacillus atrophaeus 1942]) that overlaps RNA (tRNA-N) 720555011163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011164 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 720555011165 putative substrate translocation pore; other site 720555011166 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 720555011167 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 720555011168 inhibitor-cofactor binding pocket; inhibition site 720555011169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555011170 catalytic residue [active] 720555011171 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 720555011172 active site 720555011173 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 720555011174 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 720555011175 NAD(P) binding site [chemical binding]; other site 720555011176 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 720555011177 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 720555011178 Sulfate transporter family; Region: Sulfate_transp; pfam00916 720555011179 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 720555011180 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 720555011181 Sodium Bile acid symporter family; Region: SBF; cl17470 720555011182 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 720555011183 Putative esterase; Region: Esterase; pfam00756 720555011184 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 720555011185 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555011186 ABC-ATPase subunit interface; other site 720555011187 dimer interface [polypeptide binding]; other site 720555011188 putative PBP binding regions; other site 720555011189 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 720555011190 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555011191 ABC-ATPase subunit interface; other site 720555011192 dimer interface [polypeptide binding]; other site 720555011193 putative PBP binding regions; other site 720555011194 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 720555011195 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 720555011196 putative ligand binding residues [chemical binding]; other site 720555011197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 720555011198 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 720555011199 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 720555011200 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 720555011201 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 720555011202 intersubunit interface [polypeptide binding]; other site 720555011203 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 720555011204 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 720555011205 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 720555011206 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 720555011207 Beta-lactamase; Region: Beta-lactamase; cl17358 720555011208 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 720555011209 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 720555011210 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 720555011211 active site turn [active] 720555011212 phosphorylation site [posttranslational modification] 720555011213 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 720555011214 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 720555011215 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 720555011216 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 720555011217 putative active site [active] 720555011218 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 720555011219 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 720555011220 putative active site [active] 720555011221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 720555011222 Uncharacterized conserved protein [Function unknown]; Region: COG1683 720555011223 potential protein location (hypothetical protein BATR1942_19515 [Bacillus atrophaeus 1942]) that overlaps RNA (tRNA-Q) 720555011224 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 720555011225 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555011226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555011227 DNA binding residues [nucleotide binding] 720555011228 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 720555011229 Putative zinc-finger; Region: zf-HC2; pfam13490 720555011230 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 720555011231 Uncharacterized conserved protein [Function unknown]; Region: COG1624 720555011232 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 720555011233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 720555011234 YbbR-like protein; Region: YbbR; pfam07949 720555011235 YbbR-like protein; Region: YbbR; pfam07949 720555011236 YbbR-like protein; Region: YbbR; pfam07949 720555011237 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 720555011238 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 720555011239 active site 720555011240 substrate binding site [chemical binding]; other site 720555011241 metal binding site [ion binding]; metal-binding site 720555011242 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 720555011243 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 720555011244 glutaminase active site [active] 720555011245 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 720555011246 dimer interface [polypeptide binding]; other site 720555011247 active site 720555011248 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 720555011249 dimer interface [polypeptide binding]; other site 720555011250 active site 720555011251 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 720555011252 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 720555011253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 720555011254 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 720555011255 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 720555011256 zinc binding site [ion binding]; other site 720555011257 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 720555011258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555011259 dimerization interface [polypeptide binding]; other site 720555011260 putative DNA binding site [nucleotide binding]; other site 720555011261 putative Zn2+ binding site [ion binding]; other site 720555011262 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 720555011263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011264 putative substrate translocation pore; other site 720555011265 HEAT repeats; Region: HEAT_2; pfam13646 720555011266 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 720555011267 Beta-lactamase; Region: Beta-lactamase; pfam00144 720555011268 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 720555011269 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 720555011270 DNA binding residues [nucleotide binding] 720555011271 drug binding residues [chemical binding]; other site 720555011272 dimer interface [polypeptide binding]; other site 720555011273 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 720555011274 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 720555011275 putative FMN binding site [chemical binding]; other site 720555011276 NADPH bind site [chemical binding]; other site 720555011277 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555011278 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 720555011279 acyl-activating enzyme (AAE) consensus motif; other site 720555011280 AMP binding site [chemical binding]; other site 720555011281 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555011282 Condensation domain; Region: Condensation; pfam00668 720555011283 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555011284 Nonribosomal peptide synthase; Region: NRPS; pfam08415 720555011285 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 720555011286 acyl-activating enzyme (AAE) consensus motif; other site 720555011287 AMP binding site [chemical binding]; other site 720555011288 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555011289 Condensation domain; Region: Condensation; pfam00668 720555011290 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555011291 tyrosine decarboxylase; Region: PLN02880 720555011292 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 720555011293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 720555011294 catalytic residue [active] 720555011295 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 720555011296 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 720555011297 active site 720555011298 catalytic tetrad [active] 720555011299 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 720555011300 LrgA family; Region: LrgA; cl00608 720555011301 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555011302 MarR family; Region: MarR; pfam01047 720555011303 putative transport protein YifK; Provisional; Region: PRK10746 720555011304 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 720555011305 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 720555011306 Cytochrome P450; Region: p450; cl12078 720555011307 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 720555011308 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 720555011309 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 720555011310 active site 720555011311 catalytic site [active] 720555011312 metal binding site [ion binding]; metal-binding site 720555011313 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 720555011314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011315 putative substrate translocation pore; other site 720555011316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011317 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 720555011318 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 720555011319 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 720555011320 Walker A/P-loop; other site 720555011321 ATP binding site [chemical binding]; other site 720555011322 Q-loop/lid; other site 720555011323 ABC transporter signature motif; other site 720555011324 Walker B; other site 720555011325 D-loop; other site 720555011326 H-loop/switch region; other site 720555011327 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 720555011328 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 720555011329 putative ADP-binding pocket [chemical binding]; other site 720555011330 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 720555011331 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 720555011332 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 720555011333 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 720555011334 active site 720555011335 HIGH motif; other site 720555011336 nucleotide binding site [chemical binding]; other site 720555011337 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 720555011338 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 720555011339 putative transposase OrfB; Reviewed; Region: PHA02517 720555011340 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 720555011341 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 720555011342 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 720555011343 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 720555011344 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 720555011345 active site 720555011346 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 720555011347 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 720555011348 putative active site [active] 720555011349 metal binding site [ion binding]; metal-binding site 720555011350 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 720555011351 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 720555011352 ATP-grasp domain; Region: ATP-grasp; pfam02222 720555011353 SurA N-terminal domain; Region: SurA_N; pfam09312 720555011354 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 720555011355 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 720555011356 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 720555011357 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 720555011358 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 720555011359 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 720555011360 glutamate dehydrogenase; Provisional; Region: PRK09414 720555011361 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 720555011362 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 720555011363 NAD(P) binding site [chemical binding]; other site 720555011364 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 720555011365 active site 720555011366 catalytic triad [active] 720555011367 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 720555011368 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 720555011369 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 720555011370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 720555011371 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 720555011372 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 720555011373 active site residue [active] 720555011374 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 720555011375 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 720555011376 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 720555011377 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 720555011378 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 720555011379 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 720555011380 active site 720555011381 trimer interface [polypeptide binding]; other site 720555011382 allosteric site; other site 720555011383 active site lid [active] 720555011384 hexamer (dimer of trimers) interface [polypeptide binding]; other site 720555011385 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 720555011386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555011387 DNA-binding site [nucleotide binding]; DNA binding site 720555011388 UTRA domain; Region: UTRA; pfam07702 720555011389 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 720555011390 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 720555011391 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 720555011392 homodimer interface [polypeptide binding]; other site 720555011393 substrate-cofactor binding pocket; other site 720555011394 catalytic residue [active] 720555011395 S-methylmethionine transporter; Provisional; Region: PRK11387 720555011396 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 720555011397 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 720555011398 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 720555011399 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 720555011400 glutaminase; Reviewed; Region: PRK12357 720555011401 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 720555011402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 720555011403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555011404 ATP binding site [chemical binding]; other site 720555011405 Mg2+ binding site [ion binding]; other site 720555011406 G-X-G motif; other site 720555011407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555011408 Response regulator receiver domain; Region: Response_reg; pfam00072 720555011409 active site 720555011410 phosphorylation site [posttranslational modification] 720555011411 intermolecular recognition site; other site 720555011412 dimerization interface [polypeptide binding]; other site 720555011413 YcbB domain; Region: YcbB; pfam08664 720555011414 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 720555011415 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 720555011416 putative active site [active] 720555011417 catalytic residue [active] 720555011418 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 720555011419 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 720555011420 NAD(P) binding site [chemical binding]; other site 720555011421 catalytic residues [active] 720555011422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011423 D-galactonate transporter; Region: 2A0114; TIGR00893 720555011424 putative substrate translocation pore; other site 720555011425 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 720555011426 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 720555011427 active site 720555011428 tetramer interface [polypeptide binding]; other site 720555011429 Transcriptional regulators [Transcription]; Region: FadR; COG2186 720555011430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555011431 DNA-binding site [nucleotide binding]; DNA binding site 720555011432 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 720555011433 galactarate dehydratase; Region: galactar-dH20; TIGR03248 720555011434 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 720555011435 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 720555011436 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 720555011437 putative active site [active] 720555011438 putative substrate binding site [chemical binding]; other site 720555011439 Phosphotransferase enzyme family; Region: APH; pfam01636 720555011440 ATP binding site [chemical binding]; other site 720555011441 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 720555011442 dodecamer interface 1 [polypeptide binding]; other site 720555011443 dodecamer interface 2 [polypeptide binding]; other site 720555011444 trimer interface [polypeptide binding]; other site 720555011445 TRAP binding interface [polypeptide binding]; other site 720555011446 Zn binding site [ion binding]; other site 720555011447 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 720555011448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555011449 active site 720555011450 phosphorylation site [posttranslational modification] 720555011451 intermolecular recognition site; other site 720555011452 dimerization interface [polypeptide binding]; other site 720555011453 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 720555011454 DNA binding site [nucleotide binding] 720555011455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 720555011456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 720555011457 dimer interface [polypeptide binding]; other site 720555011458 phosphorylation site [posttranslational modification] 720555011459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555011460 ATP binding site [chemical binding]; other site 720555011461 Mg2+ binding site [ion binding]; other site 720555011462 G-X-G motif; other site 720555011463 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 720555011464 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 720555011465 Walker A/P-loop; other site 720555011466 ATP binding site [chemical binding]; other site 720555011467 Q-loop/lid; other site 720555011468 ABC transporter signature motif; other site 720555011469 Walker B; other site 720555011470 D-loop; other site 720555011471 H-loop/switch region; other site 720555011472 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 720555011473 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 720555011474 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 720555011475 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 720555011476 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 720555011477 serpin-like protein; Provisional; Region: PHA02660 720555011478 reactive center loop; other site 720555011479 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 720555011480 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 720555011481 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 720555011482 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 720555011483 putative active site [active] 720555011484 putative metal binding site [ion binding]; other site 720555011485 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 720555011486 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 720555011487 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 720555011488 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 720555011489 putative substrate binding pocket [chemical binding]; other site 720555011490 AC domain interface; other site 720555011491 catalytic triad [active] 720555011492 AB domain interface; other site 720555011493 interchain disulfide; other site 720555011494 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 720555011495 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 720555011496 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 720555011497 catalytic residue [active] 720555011498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011499 Major Facilitator Superfamily; Region: MFS_1; pfam07690 720555011500 putative substrate translocation pore; other site 720555011501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555011503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555011504 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 720555011505 Lipase (class 2); Region: Lipase_2; pfam01674 720555011506 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 720555011507 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 720555011508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 720555011509 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 720555011510 active site 720555011511 catalytic tetrad [active] 720555011512 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 720555011513 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 720555011514 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 720555011515 metal binding site 2 [ion binding]; metal-binding site 720555011516 putative DNA binding helix; other site 720555011517 metal binding site 1 [ion binding]; metal-binding site 720555011518 dimer interface [polypeptide binding]; other site 720555011519 structural Zn2+ binding site [ion binding]; other site 720555011520 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 720555011521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555011522 binding surface 720555011523 TPR motif; other site 720555011524 glucose-1-dehydrogenase; Provisional; Region: PRK08936 720555011525 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 720555011526 NAD binding site [chemical binding]; other site 720555011527 homodimer interface [polypeptide binding]; other site 720555011528 active site 720555011529 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 720555011530 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 720555011531 Ca binding site [ion binding]; other site 720555011532 active site 720555011533 catalytic site [active] 720555011534 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 720555011535 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 720555011536 metal binding site [ion binding]; metal-binding site 720555011537 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 720555011538 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 720555011539 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 720555011540 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555011541 ABC-ATPase subunit interface; other site 720555011542 dimer interface [polypeptide binding]; other site 720555011543 putative PBP binding regions; other site 720555011544 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 720555011545 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 720555011546 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 720555011547 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 720555011548 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 720555011549 putative metal binding site [ion binding]; other site 720555011550 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 720555011551 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 720555011552 putative metal binding site [ion binding]; other site 720555011553 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 720555011554 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 720555011555 putative metal binding site [ion binding]; other site 720555011556 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 720555011557 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 720555011558 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 720555011559 active site 720555011560 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 720555011561 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 720555011562 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 720555011563 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 720555011564 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 720555011565 benzoate transport; Region: 2A0115; TIGR00895 720555011566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011567 putative substrate translocation pore; other site 720555011568 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 720555011569 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 720555011570 Walker A/P-loop; other site 720555011571 ATP binding site [chemical binding]; other site 720555011572 Q-loop/lid; other site 720555011573 ABC transporter signature motif; other site 720555011574 Walker B; other site 720555011575 D-loop; other site 720555011576 H-loop/switch region; other site 720555011577 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 720555011578 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 720555011579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555011580 dimer interface [polypeptide binding]; other site 720555011581 conserved gate region; other site 720555011582 putative PBP binding loops; other site 720555011583 ABC-ATPase subunit interface; other site 720555011584 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 720555011585 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 720555011586 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 720555011587 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 720555011588 amidohydrolase; Region: amidohydrolases; TIGR01891 720555011589 metal binding site [ion binding]; metal-binding site 720555011590 putative dimer interface [polypeptide binding]; other site 720555011591 Predicted membrane protein [Function unknown]; Region: COG1288 720555011592 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 720555011593 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 720555011594 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 720555011595 tetramer (dimer of dimers) interface [polypeptide binding]; other site 720555011596 NAD binding site [chemical binding]; other site 720555011597 dimer interface [polypeptide binding]; other site 720555011598 substrate binding site [chemical binding]; other site 720555011599 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 720555011600 L-lactate permease; Region: Lactate_perm; pfam02652 720555011601 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 720555011602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011603 putative substrate translocation pore; other site 720555011604 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555011605 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555011606 putative DNA binding site [nucleotide binding]; other site 720555011607 putative Zn2+ binding site [ion binding]; other site 720555011608 LysE type translocator; Region: LysE; pfam01810 720555011609 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 720555011610 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 720555011611 Spore germination protein; Region: Spore_permease; cl17796 720555011612 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 720555011613 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 720555011614 NAD+ synthetase; Region: nadE; TIGR00552 720555011615 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 720555011616 homodimer interface [polypeptide binding]; other site 720555011617 NAD binding pocket [chemical binding]; other site 720555011618 ATP binding pocket [chemical binding]; other site 720555011619 Mg binding site [ion binding]; other site 720555011620 active-site loop [active] 720555011621 AAA domain; Region: AAA_33; pfam13671 720555011622 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 720555011623 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 720555011624 shikimate kinase; Reviewed; Region: aroK; PRK00131 720555011625 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 720555011626 ADP binding site [chemical binding]; other site 720555011627 magnesium binding site [ion binding]; other site 720555011628 putative shikimate binding site; other site 720555011629 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 720555011630 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 720555011631 Proline dehydrogenase; Region: Pro_dh; pfam01619 720555011632 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 720555011633 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 720555011634 Glutamate binding site [chemical binding]; other site 720555011635 homodimer interface [polypeptide binding]; other site 720555011636 NAD binding site [chemical binding]; other site 720555011637 catalytic residues [active] 720555011638 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 720555011639 Na binding site [ion binding]; other site 720555011640 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 720555011641 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 720555011642 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 720555011643 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 720555011644 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 720555011645 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 720555011646 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 720555011647 Walker A/P-loop; other site 720555011648 ATP binding site [chemical binding]; other site 720555011649 Q-loop/lid; other site 720555011650 ABC transporter signature motif; other site 720555011651 Walker B; other site 720555011652 D-loop; other site 720555011653 H-loop/switch region; other site 720555011654 Predicted membrane protein [Function unknown]; Region: COG3689 720555011655 Predicted permeases [General function prediction only]; Region: COG0701 720555011656 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 720555011657 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 720555011658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 720555011659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555011660 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 720555011661 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 720555011662 active site 720555011663 SAM binding site [chemical binding]; other site 720555011664 homodimer interface [polypeptide binding]; other site 720555011665 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 720555011666 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 720555011667 [2Fe-2S] cluster binding site [ion binding]; other site 720555011668 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 720555011669 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555011670 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 720555011671 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 720555011672 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 720555011673 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 720555011674 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 720555011675 [4Fe-4S] binding site [ion binding]; other site 720555011676 molybdopterin cofactor binding site; other site 720555011677 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 720555011678 molybdopterin cofactor binding site; other site 720555011679 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 720555011680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 720555011681 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 720555011682 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 720555011683 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 720555011684 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 720555011685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011686 putative substrate translocation pore; other site 720555011687 putative GTP cyclohydrolase; Provisional; Region: PRK13674 720555011688 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 720555011689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 720555011690 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 720555011691 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 720555011692 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 720555011693 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 720555011694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555011695 dimer interface [polypeptide binding]; other site 720555011696 conserved gate region; other site 720555011697 putative PBP binding loops; other site 720555011698 ABC-ATPase subunit interface; other site 720555011699 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 720555011700 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 720555011701 substrate binding pocket [chemical binding]; other site 720555011702 membrane-bound complex binding site; other site 720555011703 hinge residues; other site 720555011704 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 720555011705 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 720555011706 NAD binding site [chemical binding]; other site 720555011707 catalytic Zn binding site [ion binding]; other site 720555011708 structural Zn binding site [ion binding]; other site 720555011709 RDD family; Region: RDD; pfam06271 720555011710 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 720555011711 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 720555011712 MarR family; Region: MarR_2; pfam12802 720555011713 hypothetical protein; Provisional; Region: PRK09272 720555011714 Predicted ATPase [General function prediction only]; Region: COG3910 720555011715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 720555011716 Walker A/P-loop; other site 720555011717 ATP binding site [chemical binding]; other site 720555011718 Q-loop/lid; other site 720555011719 ABC transporter signature motif; other site 720555011720 Walker B; other site 720555011721 D-loop; other site 720555011722 H-loop/switch region; other site 720555011723 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 720555011724 beta-galactosidase; Region: BGL; TIGR03356 720555011725 Competence protein J (ComJ); Region: ComJ; pfam11033 720555011726 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 720555011727 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 720555011728 dimerization interface [polypeptide binding]; other site 720555011729 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 720555011730 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 720555011731 dimer interface [polypeptide binding]; other site 720555011732 putative CheW interface [polypeptide binding]; other site 720555011733 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 720555011734 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 720555011735 tetramer interface [polypeptide binding]; other site 720555011736 active site 720555011737 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 720555011738 active site 720555011739 dimer interface [polypeptide binding]; other site 720555011740 magnesium binding site [ion binding]; other site 720555011741 Predicted transcriptional regulators [Transcription]; Region: COG1733 720555011742 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 720555011743 Condensation domain; Region: Condensation; pfam00668 720555011744 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555011745 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555011746 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555011747 acyl-activating enzyme (AAE) consensus motif; other site 720555011748 AMP binding site [chemical binding]; other site 720555011749 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555011750 Condensation domain; Region: Condensation; pfam00668 720555011751 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555011752 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555011753 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 720555011754 acyl-activating enzyme (AAE) consensus motif; other site 720555011755 AMP binding site [chemical binding]; other site 720555011756 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555011757 Condensation domain; Region: Condensation; pfam00668 720555011758 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555011759 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555011760 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555011761 acyl-activating enzyme (AAE) consensus motif; other site 720555011762 AMP binding site [chemical binding]; other site 720555011763 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555011764 Condensation domain; Region: Condensation; pfam00668 720555011765 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 720555011766 Condensation domain; Region: Condensation; pfam00668 720555011767 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555011768 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 720555011769 acyl-activating enzyme (AAE) consensus motif; other site 720555011770 AMP binding site [chemical binding]; other site 720555011771 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555011772 Condensation domain; Region: Condensation; pfam00668 720555011773 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555011774 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555011775 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555011776 acyl-activating enzyme (AAE) consensus motif; other site 720555011777 AMP binding site [chemical binding]; other site 720555011778 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555011779 Condensation domain; Region: Condensation; pfam00668 720555011780 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555011781 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 720555011782 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 720555011783 acyl-activating enzyme (AAE) consensus motif; other site 720555011784 AMP binding site [chemical binding]; other site 720555011785 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555011786 Condensation domain; Region: Condensation; pfam00668 720555011787 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555011788 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 720555011789 Condensation domain; Region: Condensation; pfam00668 720555011790 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 720555011791 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 720555011792 acyl-activating enzyme (AAE) consensus motif; other site 720555011793 AMP binding site [chemical binding]; other site 720555011794 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 720555011795 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 720555011796 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 720555011797 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 720555011798 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 720555011799 dimer interface [polypeptide binding]; other site 720555011800 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 720555011801 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 720555011802 EamA-like transporter family; Region: EamA; pfam00892 720555011803 EamA-like transporter family; Region: EamA; pfam00892 720555011804 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 720555011805 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555011806 DNA-binding site [nucleotide binding]; DNA binding site 720555011807 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555011808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555011809 homodimer interface [polypeptide binding]; other site 720555011810 catalytic residue [active] 720555011811 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 720555011812 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 720555011813 Predicted membrane protein [Function unknown]; Region: COG2364 720555011814 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 720555011815 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 720555011816 Walker A/P-loop; other site 720555011817 ATP binding site [chemical binding]; other site 720555011818 Q-loop/lid; other site 720555011819 ABC transporter signature motif; other site 720555011820 Walker B; other site 720555011821 D-loop; other site 720555011822 H-loop/switch region; other site 720555011823 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 720555011824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555011825 dimer interface [polypeptide binding]; other site 720555011826 conserved gate region; other site 720555011827 putative PBP binding loops; other site 720555011828 ABC-ATPase subunit interface; other site 720555011829 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 720555011830 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 720555011831 substrate binding pocket [chemical binding]; other site 720555011832 membrane-bound complex binding site; other site 720555011833 hinge residues; other site 720555011834 Transcriptional regulator [Transcription]; Region: LysR; COG0583 720555011835 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 720555011836 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 720555011837 dimerization interface [polypeptide binding]; other site 720555011838 Flavoprotein; Region: Flavoprotein; pfam02441 720555011839 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 720555011840 UbiD family decarboxylase; Region: TIGR00148 720555011841 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 720555011842 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 720555011843 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 720555011844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011845 putative substrate translocation pore; other site 720555011846 POT family; Region: PTR2; pfam00854 720555011847 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 720555011848 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 720555011849 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 720555011850 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 720555011851 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 720555011852 Spore germination protein; Region: Spore_permease; pfam03845 720555011853 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 720555011854 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 720555011855 active site 720555011856 non-prolyl cis peptide bond; other site 720555011857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 720555011858 Coenzyme A binding pocket [chemical binding]; other site 720555011859 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 720555011860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 720555011861 substrate binding pocket [chemical binding]; other site 720555011862 membrane-bound complex binding site; other site 720555011863 hinge residues; other site 720555011864 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 720555011865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 720555011866 dimer interface [polypeptide binding]; other site 720555011867 conserved gate region; other site 720555011868 putative PBP binding loops; other site 720555011869 ABC-ATPase subunit interface; other site 720555011870 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 720555011871 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 720555011872 Walker A/P-loop; other site 720555011873 ATP binding site [chemical binding]; other site 720555011874 Q-loop/lid; other site 720555011875 ABC transporter signature motif; other site 720555011876 Walker B; other site 720555011877 D-loop; other site 720555011878 H-loop/switch region; other site 720555011879 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 720555011880 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 720555011881 metal binding site [ion binding]; metal-binding site 720555011882 dimer interface [polypeptide binding]; other site 720555011883 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 720555011884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 720555011885 binding surface 720555011886 TPR motif; other site 720555011887 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555011888 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555011889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 720555011890 TPR motif; other site 720555011891 binding surface 720555011892 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555011893 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 720555011894 aspartate kinase; Reviewed; Region: PRK09034 720555011895 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 720555011896 putative catalytic residues [active] 720555011897 putative nucleotide binding site [chemical binding]; other site 720555011898 putative aspartate binding site [chemical binding]; other site 720555011899 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 720555011900 allosteric regulatory residue; other site 720555011901 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 720555011902 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 720555011903 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555011904 ABC-ATPase subunit interface; other site 720555011905 dimer interface [polypeptide binding]; other site 720555011906 putative PBP binding regions; other site 720555011907 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 720555011908 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 720555011909 ABC-ATPase subunit interface; other site 720555011910 dimer interface [polypeptide binding]; other site 720555011911 putative PBP binding regions; other site 720555011912 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 720555011913 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 720555011914 Walker A/P-loop; other site 720555011915 ATP binding site [chemical binding]; other site 720555011916 Q-loop/lid; other site 720555011917 ABC transporter signature motif; other site 720555011918 Walker B; other site 720555011919 D-loop; other site 720555011920 H-loop/switch region; other site 720555011921 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 720555011922 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 720555011923 putative ligand binding residues [chemical binding]; other site 720555011924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011925 putative substrate translocation pore; other site 720555011926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 720555011927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 720555011928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 720555011929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 720555011930 binding surface 720555011931 TPR motif; other site 720555011932 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555011933 Tetratricopeptide repeat; Region: TPR_12; pfam13424 720555011934 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 720555011935 dimer interface [polypeptide binding]; other site 720555011936 FMN binding site [chemical binding]; other site 720555011937 NADPH bind site [chemical binding]; other site 720555011938 Uncharacterized conserved protein [Function unknown]; Region: COG1359 720555011939 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555011940 dimerization interface [polypeptide binding]; other site 720555011941 putative DNA binding site [nucleotide binding]; other site 720555011942 putative Zn2+ binding site [ion binding]; other site 720555011943 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 720555011944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 720555011945 DNA-binding site [nucleotide binding]; DNA binding site 720555011946 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 720555011947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555011948 homodimer interface [polypeptide binding]; other site 720555011949 catalytic residue [active] 720555011950 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 720555011951 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 720555011952 inhibitor-cofactor binding pocket; inhibition site 720555011953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 720555011954 catalytic residue [active] 720555011955 succinic semialdehyde dehydrogenase; Region: PLN02278 720555011956 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 720555011957 tetramerization interface [polypeptide binding]; other site 720555011958 NAD(P) binding site [chemical binding]; other site 720555011959 catalytic residues [active] 720555011960 Sugar transport protein; Region: Sugar_transport; pfam06800 720555011961 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 720555011962 glucose-1-dehydrogenase; Provisional; Region: PRK08936 720555011963 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 720555011964 NAD binding site [chemical binding]; other site 720555011965 homodimer interface [polypeptide binding]; other site 720555011966 active site 720555011967 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 720555011968 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 720555011969 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 720555011970 YtkA-like; Region: YtkA; pfam13115 720555011971 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 720555011972 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 720555011973 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 720555011974 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 720555011975 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 720555011976 active site 720555011977 P-loop; other site 720555011978 phosphorylation site [posttranslational modification] 720555011979 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 720555011980 active site 720555011981 phosphorylation site [posttranslational modification] 720555011982 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 720555011983 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 720555011984 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 720555011985 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 720555011986 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 720555011987 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 720555011988 nudix motif; other site 720555011989 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 720555011990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555011991 active site 720555011992 motif I; other site 720555011993 motif II; other site 720555011994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 720555011995 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 720555011996 putative active site [active] 720555011997 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 720555011998 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 720555011999 hypothetical protein; Provisional; Region: PRK05463 720555012000 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 720555012001 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 720555012002 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 720555012003 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 720555012004 Transcriptional regulator [Transcription]; Region: IclR; COG1414 720555012005 Bacterial transcriptional regulator; Region: IclR; pfam01614 720555012006 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 720555012007 active site 720555012008 catalytic triad [active] 720555012009 oxyanion hole [active] 720555012010 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 720555012011 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 720555012012 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 720555012013 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 720555012014 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 720555012015 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 720555012016 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 720555012017 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 720555012018 active site 720555012019 catalytic tetrad [active] 720555012020 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 720555012021 HTH domain; Region: HTH_11; pfam08279 720555012022 HTH domain; Region: HTH_11; pfam08279 720555012023 PRD domain; Region: PRD; pfam00874 720555012024 PRD domain; Region: PRD; pfam00874 720555012025 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 720555012026 active site 720555012027 P-loop; other site 720555012028 phosphorylation site [posttranslational modification] 720555012029 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 720555012030 active site 720555012031 phosphorylation site [posttranslational modification] 720555012032 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 720555012033 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 720555012034 acyl-activating enzyme (AAE) consensus motif; other site 720555012035 putative AMP binding site [chemical binding]; other site 720555012036 putative active site [active] 720555012037 putative CoA binding site [chemical binding]; other site 720555012038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 720555012039 S-adenosylmethionine binding site [chemical binding]; other site 720555012040 short chain dehydrogenase; Provisional; Region: PRK06701 720555012041 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 720555012042 NAD binding site [chemical binding]; other site 720555012043 metal binding site [ion binding]; metal-binding site 720555012044 active site 720555012045 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 720555012046 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 720555012047 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 720555012048 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 720555012049 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 720555012050 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 720555012051 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 720555012052 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 720555012053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555012054 non-specific DNA binding site [nucleotide binding]; other site 720555012055 salt bridge; other site 720555012056 sequence-specific DNA binding site [nucleotide binding]; other site 720555012057 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 720555012058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 720555012059 putative DNA binding site [nucleotide binding]; other site 720555012060 putative Zn2+ binding site [ion binding]; other site 720555012061 AsnC family; Region: AsnC_trans_reg; pfam01037 720555012062 DNA topoisomerase III; Provisional; Region: PRK07726 720555012063 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 720555012064 active site 720555012065 putative interdomain interaction site [polypeptide binding]; other site 720555012066 putative metal-binding site [ion binding]; other site 720555012067 putative nucleotide binding site [chemical binding]; other site 720555012068 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 720555012069 domain I; other site 720555012070 DNA binding groove [nucleotide binding] 720555012071 phosphate binding site [ion binding]; other site 720555012072 domain II; other site 720555012073 domain III; other site 720555012074 nucleotide binding site [chemical binding]; other site 720555012075 catalytic site [active] 720555012076 domain IV; other site 720555012077 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 720555012078 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 720555012079 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 720555012080 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 720555012081 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 720555012082 metal binding site [ion binding]; metal-binding site 720555012083 active site 720555012084 I-site; other site 720555012085 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 720555012086 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 720555012087 NodB motif; other site 720555012088 putative active site [active] 720555012089 putative catalytic site [active] 720555012090 putative Zn binding site [ion binding]; other site 720555012091 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 720555012092 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 720555012093 DXD motif; other site 720555012094 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 720555012095 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 720555012096 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 720555012097 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 720555012098 nudix motif; other site 720555012099 pyruvate oxidase; Provisional; Region: PRK08611 720555012100 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 720555012101 PYR/PP interface [polypeptide binding]; other site 720555012102 tetramer interface [polypeptide binding]; other site 720555012103 dimer interface [polypeptide binding]; other site 720555012104 TPP binding site [chemical binding]; other site 720555012105 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 720555012106 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 720555012107 TPP-binding site [chemical binding]; other site 720555012108 manganese transport protein MntH; Reviewed; Region: PRK00701 720555012109 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 720555012110 Predicted membrane protein [Function unknown]; Region: COG2261 720555012111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 720555012112 EcsC protein family; Region: EcsC; pfam12787 720555012113 General stress protein [General function prediction only]; Region: GsiB; COG3729 720555012114 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 720555012115 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 720555012116 dimanganese center [ion binding]; other site 720555012117 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 720555012118 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 720555012119 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 720555012120 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 720555012121 putative active site [active] 720555012122 heme pocket [chemical binding]; other site 720555012123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555012124 ATP binding site [chemical binding]; other site 720555012125 Mg2+ binding site [ion binding]; other site 720555012126 G-X-G motif; other site 720555012127 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 720555012128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 720555012129 active site 720555012130 phosphorylation site [posttranslational modification] 720555012131 intermolecular recognition site; other site 720555012132 dimerization interface [polypeptide binding]; other site 720555012133 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 720555012134 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 720555012135 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 720555012136 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 720555012137 Domain of unknown function DUF20; Region: UPF0118; pfam01594 720555012138 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 720555012139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 720555012140 Walker A/P-loop; other site 720555012141 ATP binding site [chemical binding]; other site 720555012142 Q-loop/lid; other site 720555012143 ABC transporter signature motif; other site 720555012144 Walker B; other site 720555012145 D-loop; other site 720555012146 H-loop/switch region; other site 720555012147 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 720555012148 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 720555012149 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 720555012150 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 720555012151 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 720555012152 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 720555012153 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 720555012154 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 720555012155 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 720555012156 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 720555012157 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 720555012158 catalytic residues [active] 720555012159 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 720555012160 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 720555012161 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 720555012162 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 720555012163 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 720555012164 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 720555012165 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 720555012166 helicase 45; Provisional; Region: PTZ00424 720555012167 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 720555012168 ATP binding site [chemical binding]; other site 720555012169 Mg++ binding site [ion binding]; other site 720555012170 motif III; other site 720555012171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 720555012172 nucleotide binding region [chemical binding]; other site 720555012173 ATP-binding site [chemical binding]; other site 720555012174 Uncharacterized conserved protein [Function unknown]; Region: COG3402 720555012175 Predicted membrane protein [Function unknown]; Region: COG3428 720555012176 Bacterial PH domain; Region: DUF304; pfam03703 720555012177 Bacterial PH domain; Region: DUF304; pfam03703 720555012178 Rhomboid family; Region: Rhomboid; pfam01694 720555012179 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 720555012180 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 720555012181 alanine racemase; Region: alr; TIGR00492 720555012182 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 720555012183 active site 720555012184 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 720555012185 dimer interface [polypeptide binding]; other site 720555012186 substrate binding site [chemical binding]; other site 720555012187 catalytic residues [active] 720555012188 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 720555012189 ribbon-helix-helix domain containing protein; Region: PHA00617 720555012190 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 720555012191 Rsbr N terminal; Region: Rsbr_N; pfam08678 720555012192 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 720555012193 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 720555012194 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 720555012195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555012196 ATP binding site [chemical binding]; other site 720555012197 Mg2+ binding site [ion binding]; other site 720555012198 G-X-G motif; other site 720555012199 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 720555012200 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 720555012201 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 720555012202 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 720555012203 anti sigma factor interaction site; other site 720555012204 regulatory phosphorylation site [posttranslational modification]; other site 720555012205 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 720555012206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 720555012207 ATP binding site [chemical binding]; other site 720555012208 Mg2+ binding site [ion binding]; other site 720555012209 G-X-G motif; other site 720555012210 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 720555012211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 720555012212 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 720555012213 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 720555012214 DNA binding residues [nucleotide binding] 720555012215 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 720555012216 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 720555012217 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 720555012218 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 720555012219 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 720555012220 RNA binding site [nucleotide binding]; other site 720555012221 hypothetical protein; Provisional; Region: PRK04351 720555012222 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 720555012223 integrase; Provisional; Region: int; PHA02601 720555012224 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 720555012225 Int/Topo IB signature motif; other site 720555012226 Domain of unknown function (DUF955); Region: DUF955; cl01076 720555012227 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 720555012228 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 720555012229 non-specific DNA binding site [nucleotide binding]; other site 720555012230 salt bridge; other site 720555012231 sequence-specific DNA binding site [nucleotide binding]; other site 720555012232 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775