-- dump date 20140618_212340 -- class Genbank::misc_feature -- table misc_feature_note -- id note 768494000001 Nuclease-related domain; Region: NERD; pfam08378 768494000002 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 768494000003 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 768494000004 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 768494000005 putative active site [active] 768494000006 putative NTP binding site [chemical binding]; other site 768494000007 putative nucleic acid binding site [nucleotide binding]; other site 768494000008 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 768494000009 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 768494000010 active site 768494000011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494000012 S-adenosylmethionine binding site [chemical binding]; other site 768494000013 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 768494000014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494000015 non-specific DNA binding site [nucleotide binding]; other site 768494000016 sequence-specific DNA binding site [nucleotide binding]; other site 768494000017 salt bridge; other site 768494000018 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 768494000019 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 768494000020 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 768494000021 active site 768494000022 catalytic residues [active] 768494000023 DNA binding site [nucleotide binding] 768494000024 Int/Topo IB signature motif; other site 768494000025 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768494000026 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768494000027 Ligand Binding Site [chemical binding]; other site 768494000028 HEPN domain; Region: HEPN; pfam05168 768494000029 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 768494000030 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 768494000031 putative active site [active] 768494000032 putative NTP binding site [chemical binding]; other site 768494000033 putative nucleic acid binding site [nucleotide binding]; other site 768494000034 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 768494000035 active site 768494000036 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 768494000037 active site 768494000038 NTP binding site [chemical binding]; other site 768494000039 metal binding triad [ion binding]; metal-binding site 768494000040 antibiotic binding site [chemical binding]; other site 768494000041 Divergent AAA domain; Region: AAA_4; pfam04326 768494000042 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 768494000043 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 768494000044 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 768494000045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494000046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494000047 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768494000048 Abi-like protein; Region: Abi_2; pfam07751 768494000049 putative acetyltransferase; Provisional; Region: PRK03624 768494000050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494000051 Coenzyme A binding pocket [chemical binding]; other site 768494000052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768494000053 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768494000054 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494000055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494000056 non-specific DNA binding site [nucleotide binding]; other site 768494000057 salt bridge; other site 768494000058 sequence-specific DNA binding site [nucleotide binding]; other site 768494000059 AAA-like domain; Region: AAA_10; pfam12846 768494000060 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 768494000061 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 768494000062 Replication-relaxation; Region: Replic_Relax; pfam13814 768494000063 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 768494000064 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 768494000065 DNA binding residues [nucleotide binding] 768494000066 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 768494000067 S-layer homology domain; Region: SLH; pfam00395 768494000068 S-layer homology domain; Region: SLH; pfam00395 768494000069 S-layer homology domain; Region: SLH; pfam00395 768494000070 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 768494000071 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 768494000072 potential frameshift: common BLAST hit: gi|227811504|ref|YP_002811515.1| SAF domain family 768494000073 AAA domain; Region: AAA_31; pfam13614 768494000074 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768494000075 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 768494000076 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768494000077 Walker A motif; other site 768494000078 ATP binding site [chemical binding]; other site 768494000079 Walker B motif; other site 768494000080 WxL domain surface cell wall-binding; Region: WxL; pfam13731 768494000081 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 768494000082 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 768494000083 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 768494000084 active site 768494000085 metal binding site [ion binding]; metal-binding site 768494000086 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 768494000087 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 768494000088 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 768494000089 PrgI family protein; Region: PrgI; pfam12666 768494000090 AAA-like domain; Region: AAA_10; pfam12846 768494000091 potential frameshift: common BLAST hit: gi|301068140|ref|YP_003786911.1| membrane protein 768494000092 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 768494000093 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768494000094 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768494000095 catalytic residue [active] 768494000096 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 768494000097 Peptidase family M23; Region: Peptidase_M23; pfam01551 768494000098 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768494000099 NlpC/P60 family; Region: NLPC_P60; pfam00877 768494000100 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 768494000101 CAAX protease self-immunity; Region: Abi; pfam02517 768494000102 Predicted membrane protein [Function unknown]; Region: COG2311 768494000103 Protein of unknown function (DUF418); Region: DUF418; cl12135 768494000104 Protein of unknown function (DUF418); Region: DUF418; pfam04235 768494000105 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768494000106 catalytic residues [active] 768494000107 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 768494000108 heme-binding site [chemical binding]; other site 768494000109 S-layer homology domain; Region: SLH; pfam00395 768494000110 S-layer homology domain; Region: SLH; pfam00395 768494000111 S-layer homology domain; Region: SLH; pfam00395 768494000112 Acetokinase family; Region: Acetate_kinase; cl17229 768494000113 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 768494000114 active site 768494000115 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768494000116 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768494000117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494000118 active site 768494000119 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768494000120 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 768494000121 active site 768494000122 tetramer interface; other site 768494000123 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 768494000124 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768494000125 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 768494000126 Winged helix-turn helix; Region: HTH_29; pfam13551 768494000127 Homeodomain-like domain; Region: HTH_23; pfam13384 768494000128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 768494000129 HTH-like domain; Region: HTH_21; pfam13276 768494000130 Integrase core domain; Region: rve; pfam00665 768494000131 Integrase core domain; Region: rve_3; cl15866 768494000132 Integrase core domain; Region: rve; pfam00665 768494000133 CRISPR/Cas system-associated protein Cas8c; Region: Csp2_I-U; cl11894 768494000134 Integrase core domain; Region: rve_3; cl15866 768494000135 Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737 768494000136 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 768494000137 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768494000138 active site 768494000139 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 768494000140 Transposase domain (DUF772); Region: DUF772; pfam05598 768494000141 HTH domain; Region: HTH_11; cl17392 768494000142 Mga helix-turn-helix domain; Region: Mga; pfam05043 768494000143 PRD domain; Region: PRD; pfam00874 768494000144 PRD domain; Region: PRD; pfam00874 768494000145 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 768494000146 Histidine kinase N terminal; Region: HisK_N; pfam09385 768494000147 potential frameshift: common BLAST hit: gi|21392830|ref|NP_652910.1| transposase X 768494000148 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 768494000149 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 768494000150 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 768494000151 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 768494000152 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 768494000153 catalytic residues [active] 768494000154 catalytic nucleophile [active] 768494000155 Presynaptic Site I dimer interface [polypeptide binding]; other site 768494000156 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 768494000157 Synaptic Flat tetramer interface [polypeptide binding]; other site 768494000158 Synaptic Site I dimer interface [polypeptide binding]; other site 768494000159 DNA binding site [nucleotide binding] 768494000160 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 768494000161 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 768494000162 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 768494000163 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 768494000164 PA14 domain; Region: PA14; pfam07691 768494000165 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 768494000166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494000167 dimerization interface [polypeptide binding]; other site 768494000168 putative DNA binding site [nucleotide binding]; other site 768494000169 putative Zn2+ binding site [ion binding]; other site 768494000170 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 768494000171 Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737 768494000172 Anthrax toxin lethal factor, middle domain; Region: Anthrax-tox_M; pfam09156 768494000173 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 768494000174 active site 768494000175 conformational flexibility of ligand binding pocket; other site 768494000176 ADP-ribosylating toxin turn-turn motif; other site 768494000177 Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737 768494000178 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 768494000179 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 768494000180 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 768494000181 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768494000182 active site 768494000183 Int/Topo IB signature motif; other site 768494000184 DNA binding site [nucleotide binding] 768494000185 Helix-turn-helix domain; Region: HTH_17; pfam12728 768494000186 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 768494000187 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 768494000188 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 768494000189 Integrase core domain; Region: rve_3; cl15866 768494000190 Winged helix-turn helix; Region: HTH_29; pfam13551 768494000191 Homeodomain-like domain; Region: HTH_23; pfam13384 768494000192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 768494000193 HTH-like domain; Region: HTH_21; pfam13276 768494000194 Integrase core domain; Region: rve; pfam00665 768494000195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 768494000196 Homeodomain-like domain; Region: HTH_23; cl17451 768494000197 Homeodomain-like domain; Region: HTH_23; cl17451 768494000198 HTH-like domain; Region: HTH_21; pfam13276 768494000199 Integrase core domain; Region: rve; pfam00665 768494000200 Integrase core domain; Region: rve_2; pfam13333 768494000201 YodA lipocalin-like domain; Region: YodA; pfam09223 768494000202 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768494000203 synthetase active site [active] 768494000204 NTP binding site [chemical binding]; other site 768494000205 metal binding site [ion binding]; metal-binding site 768494000206 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 768494000207 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768494000208 active site 768494000209 DNA binding site [nucleotide binding] 768494000210 Int/Topo IB signature motif; other site 768494000211 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 768494000212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 768494000213 Walker A motif; other site 768494000214 ATP binding site [chemical binding]; other site 768494000215 Walker B motif; other site 768494000216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768494000217 TPR motif; other site 768494000218 binding surface 768494000219 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768494000220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494000221 TPR motif; other site 768494000222 binding surface 768494000223 bacterial Hfq-like; Region: Hfq; cd01716 768494000224 hexamer interface [polypeptide binding]; other site 768494000225 Sm1 motif; other site 768494000226 RNA binding site [nucleotide binding]; other site 768494000227 Sm2 motif; other site 768494000228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494000229 dimerization interface [polypeptide binding]; other site 768494000230 putative DNA binding site [nucleotide binding]; other site 768494000231 putative Zn2+ binding site [ion binding]; other site 768494000232 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 768494000233 Staphylococcal nuclease homologues; Region: SNc; smart00318 768494000234 Catalytic site; other site 768494000235 Staphylococcal nuclease homologue; Region: SNase; pfam00565 768494000236 DNA topoisomerase III; Provisional; Region: PRK07726 768494000237 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768494000238 active site 768494000239 putative interdomain interaction site [polypeptide binding]; other site 768494000240 putative metal-binding site [ion binding]; other site 768494000241 putative nucleotide binding site [chemical binding]; other site 768494000242 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768494000243 domain I; other site 768494000244 DNA binding groove [nucleotide binding] 768494000245 phosphate binding site [ion binding]; other site 768494000246 domain II; other site 768494000247 domain III; other site 768494000248 nucleotide binding site [chemical binding]; other site 768494000249 catalytic site [active] 768494000250 domain IV; other site 768494000251 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768494000252 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 768494000253 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 768494000254 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 768494000255 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 768494000256 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 768494000257 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 768494000258 Lysozyme-like; Region: Lysozyme_like; pfam13702 768494000259 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768494000260 NlpC/P60 family; Region: NLPC_P60; pfam00877 768494000261 AAA-like domain; Region: AAA_10; pfam12846 768494000262 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 768494000263 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 768494000264 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 768494000265 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768494000266 Walker A motif; other site 768494000267 ATP binding site [chemical binding]; other site 768494000268 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 768494000269 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 768494000270 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 768494000271 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768494000272 Walker A motif; other site 768494000273 ATP binding site [chemical binding]; other site 768494000274 Walker B motif; other site 768494000275 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 768494000276 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 768494000277 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768494000278 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768494000279 P-loop; other site 768494000280 Magnesium ion binding site [ion binding]; other site 768494000281 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768494000282 Magnesium ion binding site [ion binding]; other site 768494000283 S-layer homology domain; Region: SLH; pfam00395 768494000284 S-layer homology domain; Region: SLH; pfam00395 768494000285 S-layer homology domain; Region: SLH; pfam00395 768494000286 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768494000287 active site 768494000288 metal binding site [ion binding]; metal-binding site 768494000289 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 768494000290 Integrase core domain; Region: rve; pfam00665 768494000291 putative transposase OrfB; Reviewed; Region: PHA02517 768494000292 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 768494000293 CAAX protease self-immunity; Region: Abi; pfam02517 768494000294 Uncharacterized conserved protein [Function unknown]; Region: COG1683 768494000295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494000296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494000297 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768494000298 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768494000299 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768494000300 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 768494000301 active site 768494000302 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 768494000303 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 768494000304 Mga helix-turn-helix domain; Region: Mga; pfam05043 768494000305 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 768494000306 active site 768494000307 P-loop; other site 768494000308 phosphorylation site [posttranslational modification] 768494000309 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 768494000310 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 768494000311 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 768494000312 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 768494000313 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 768494000314 putative active site [active] 768494000315 putative metal binding site [ion binding]; other site 768494000316 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 768494000317 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 768494000318 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768494000319 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494000320 dimerization interface [polypeptide binding]; other site 768494000321 putative DNA binding site [nucleotide binding]; other site 768494000322 putative Zn2+ binding site [ion binding]; other site 768494000323 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768494000324 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 768494000325 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768494000326 Catalytic site [active] 768494000327 Histidine kinase N terminal; Region: HisK_N; pfam09385 768494000328 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 768494000329 PRD domain; Region: PRD; pfam00874 768494000330 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 768494000331 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 768494000332 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 768494000333 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 768494000334 Mga helix-turn-helix domain; Region: Mga; pfam05043 768494000335 CAAX protease self-immunity; Region: Abi; pfam02517 768494000336 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768494000337 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494000338 peptide binding site [polypeptide binding]; other site 768494000339 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 768494000340 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768494000341 DNA binding residues [nucleotide binding] 768494000342 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 768494000343 DNA polymerase IV; Reviewed; Region: PRK03103 768494000344 active site 768494000345 DNA binding site [nucleotide binding] 768494000346 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 768494000347 YolD-like protein; Region: YolD; pfam08863 768494000348 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 768494000349 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 768494000350 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 768494000351 active site 768494000352 catalytic residues [active] 768494000353 DNA binding site [nucleotide binding] 768494000354 Int/Topo IB signature motif; other site 768494000355 CAAX protease self-immunity; Region: Abi; pfam02517 768494000356 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 768494000357 domain III; other site 768494000358 nucleotide binding site [chemical binding]; other site 768494000359 DNA binding groove [nucleotide binding] 768494000360 catalytic site [active] 768494000361 domain II; other site 768494000362 domain IV; other site 768494000363 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768494000364 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768494000365 active site 768494000366 putative interdomain interaction site [polypeptide binding]; other site 768494000367 putative metal-binding site [ion binding]; other site 768494000368 putative nucleotide binding site [chemical binding]; other site 768494000369 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 768494000370 domain I; other site 768494000371 phosphate binding site [ion binding]; other site 768494000372 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 768494000373 Toprim-like; Region: Toprim_2; pfam13155 768494000374 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 768494000375 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 768494000376 DnaA N-terminal domain; Region: DnaA_N; pfam11638 768494000377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494000378 Walker A motif; other site 768494000379 ATP binding site [chemical binding]; other site 768494000380 Walker B motif; other site 768494000381 arginine finger; other site 768494000382 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 768494000383 DnaA box-binding interface [nucleotide binding]; other site 768494000384 DNA polymerase III subunit beta; Validated; Region: PRK05643 768494000385 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 768494000386 putative DNA binding surface [nucleotide binding]; other site 768494000387 dimer interface [polypeptide binding]; other site 768494000388 beta-clamp/clamp loader binding surface; other site 768494000389 beta-clamp/translesion DNA polymerase binding surface; other site 768494000390 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 768494000391 recombination protein F; Reviewed; Region: recF; PRK00064 768494000392 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 768494000393 Walker A/P-loop; other site 768494000394 ATP binding site [chemical binding]; other site 768494000395 Q-loop/lid; other site 768494000396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494000397 ABC transporter signature motif; other site 768494000398 Walker B; other site 768494000399 D-loop; other site 768494000400 H-loop/switch region; other site 768494000401 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 768494000402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494000403 Mg2+ binding site [ion binding]; other site 768494000404 G-X-G motif; other site 768494000405 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768494000406 anchoring element; other site 768494000407 dimer interface [polypeptide binding]; other site 768494000408 ATP binding site [chemical binding]; other site 768494000409 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 768494000410 active site 768494000411 putative metal-binding site [ion binding]; other site 768494000412 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768494000413 DNA gyrase subunit A; Validated; Region: PRK05560 768494000414 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768494000415 CAP-like domain; other site 768494000416 active site 768494000417 primary dimer interface [polypeptide binding]; other site 768494000418 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768494000419 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768494000420 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768494000421 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768494000422 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768494000423 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768494000424 YaaC-like Protein; Region: YaaC; pfam14175 768494000425 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 768494000426 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768494000427 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 768494000428 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 768494000429 active site 768494000430 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 768494000431 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768494000432 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 768494000433 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 768494000434 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 768494000435 active site 768494000436 multimer interface [polypeptide binding]; other site 768494000437 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 768494000438 predicted active site [active] 768494000439 catalytic triad [active] 768494000440 seryl-tRNA synthetase; Provisional; Region: PRK05431 768494000441 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 768494000442 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 768494000443 dimer interface [polypeptide binding]; other site 768494000444 active site 768494000445 motif 1; other site 768494000446 motif 2; other site 768494000447 motif 3; other site 768494000448 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 768494000449 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 768494000450 DNA binding residues [nucleotide binding] 768494000451 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 768494000452 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 768494000453 Substrate-binding site [chemical binding]; other site 768494000454 Substrate specificity [chemical binding]; other site 768494000455 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 768494000456 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 768494000457 Substrate-binding site [chemical binding]; other site 768494000458 Substrate specificity [chemical binding]; other site 768494000459 Isochorismatase family; Region: Isochorismatase; pfam00857 768494000460 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768494000461 catalytic triad [active] 768494000462 conserved cis-peptide bond; other site 768494000463 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 768494000464 nucleoside/Zn binding site; other site 768494000465 dimer interface [polypeptide binding]; other site 768494000466 catalytic motif [active] 768494000467 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 768494000468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494000469 Walker A motif; other site 768494000470 ATP binding site [chemical binding]; other site 768494000471 Walker B motif; other site 768494000472 arginine finger; other site 768494000473 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 768494000474 hypothetical protein; Validated; Region: PRK00153 768494000475 recombination protein RecR; Reviewed; Region: recR; PRK00076 768494000476 RecR protein; Region: RecR; pfam02132 768494000477 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 768494000478 putative active site [active] 768494000479 putative metal-binding site [ion binding]; other site 768494000480 tetramer interface [polypeptide binding]; other site 768494000481 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 768494000482 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 768494000483 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 768494000484 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 768494000485 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 768494000486 homodimer interface [polypeptide binding]; other site 768494000487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494000488 catalytic residue [active] 768494000489 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 768494000490 thymidylate kinase; Validated; Region: tmk; PRK00698 768494000491 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 768494000492 TMP-binding site; other site 768494000493 ATP-binding site [chemical binding]; other site 768494000494 DNA polymerase III subunit delta'; Validated; Region: PRK08058 768494000495 DNA polymerase III subunit delta'; Validated; Region: PRK08485 768494000496 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 768494000497 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 768494000498 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 768494000499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494000500 S-adenosylmethionine binding site [chemical binding]; other site 768494000501 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 768494000502 catalytic site [active] 768494000503 metal binding site [ion binding]; metal-binding site 768494000504 Predicted methyltransferases [General function prediction only]; Region: COG0313 768494000505 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 768494000506 putative homodimer interface [polypeptide binding]; other site 768494000507 putative SAM binding site [chemical binding]; other site 768494000508 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 768494000509 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 768494000510 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 768494000511 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 768494000512 active site 768494000513 HIGH motif; other site 768494000514 KMSKS motif; other site 768494000515 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 768494000516 tRNA binding surface [nucleotide binding]; other site 768494000517 anticodon binding site; other site 768494000518 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 768494000519 dimer interface [polypeptide binding]; other site 768494000520 putative tRNA-binding site [nucleotide binding]; other site 768494000521 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 768494000522 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768494000523 active site 768494000524 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 768494000525 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 768494000526 putative active site [active] 768494000527 putative metal binding site [ion binding]; other site 768494000528 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 768494000529 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 768494000530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494000531 S-adenosylmethionine binding site [chemical binding]; other site 768494000532 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 768494000533 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 768494000534 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 768494000535 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 768494000536 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768494000537 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768494000538 pur operon repressor; Provisional; Region: PRK09213 768494000539 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 768494000540 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768494000541 active site 768494000542 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768494000543 homotrimer interaction site [polypeptide binding]; other site 768494000544 putative active site [active] 768494000545 regulatory protein SpoVG; Reviewed; Region: PRK13259 768494000546 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 768494000547 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 768494000548 Substrate binding site; other site 768494000549 Mg++ binding site; other site 768494000550 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 768494000551 active site 768494000552 substrate binding site [chemical binding]; other site 768494000553 CoA binding site [chemical binding]; other site 768494000554 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 768494000555 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 768494000556 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768494000557 active site 768494000558 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 768494000559 putative active site [active] 768494000560 catalytic residue [active] 768494000561 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 768494000562 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 768494000563 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 768494000564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768494000565 ATP binding site [chemical binding]; other site 768494000566 putative Mg++ binding site [ion binding]; other site 768494000567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494000568 nucleotide binding region [chemical binding]; other site 768494000569 ATP-binding site [chemical binding]; other site 768494000570 TRCF domain; Region: TRCF; pfam03461 768494000571 stage V sporulation protein T; Region: spore_V_T; TIGR02851 768494000572 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 768494000573 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 768494000574 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 768494000575 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 768494000576 putative SAM binding site [chemical binding]; other site 768494000577 putative homodimer interface [polypeptide binding]; other site 768494000578 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 768494000579 homodimer interface [polypeptide binding]; other site 768494000580 metal binding site [ion binding]; metal-binding site 768494000581 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 768494000582 homodimer interface [polypeptide binding]; other site 768494000583 active site 768494000584 putative chemical substrate binding site [chemical binding]; other site 768494000585 metal binding site [ion binding]; metal-binding site 768494000586 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768494000587 RNA binding surface [nucleotide binding]; other site 768494000588 sporulation protein YabP; Region: spore_yabP; TIGR02892 768494000589 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 768494000590 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 768494000591 Septum formation initiator; Region: DivIC; pfam04977 768494000592 hypothetical protein; Provisional; Region: PRK08582 768494000593 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 768494000594 RNA binding site [nucleotide binding]; other site 768494000595 stage II sporulation protein E; Region: spore_II_E; TIGR02865 768494000596 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 768494000597 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 768494000598 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 768494000599 Ligand Binding Site [chemical binding]; other site 768494000600 TilS substrate binding domain; Region: TilS; pfam09179 768494000601 TilS substrate C-terminal domain; Region: TilS_C; smart00977 768494000602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768494000603 active site 768494000604 FtsH Extracellular; Region: FtsH_ext; pfam06480 768494000605 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 768494000606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494000607 Walker A motif; other site 768494000608 ATP binding site [chemical binding]; other site 768494000609 Walker B motif; other site 768494000610 arginine finger; other site 768494000611 Peptidase family M41; Region: Peptidase_M41; pfam01434 768494000612 pantothenate kinase; Reviewed; Region: PRK13318 768494000613 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 768494000614 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 768494000615 dimerization interface [polypeptide binding]; other site 768494000616 domain crossover interface; other site 768494000617 redox-dependent activation switch; other site 768494000618 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768494000619 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768494000620 dimer interface [polypeptide binding]; other site 768494000621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494000622 catalytic residue [active] 768494000623 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 768494000624 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768494000625 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 768494000626 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 768494000627 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 768494000628 glutamine binding [chemical binding]; other site 768494000629 catalytic triad [active] 768494000630 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768494000631 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 768494000632 homodimer interface [polypeptide binding]; other site 768494000633 substrate-cofactor binding pocket; other site 768494000634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494000635 catalytic residue [active] 768494000636 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 768494000637 dihydropteroate synthase; Region: DHPS; TIGR01496 768494000638 substrate binding pocket [chemical binding]; other site 768494000639 dimer interface [polypeptide binding]; other site 768494000640 inhibitor binding site; inhibition site 768494000641 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 768494000642 homooctamer interface [polypeptide binding]; other site 768494000643 active site 768494000644 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 768494000645 catalytic center binding site [active] 768494000646 ATP binding site [chemical binding]; other site 768494000647 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 768494000648 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768494000649 FMN binding site [chemical binding]; other site 768494000650 active site 768494000651 catalytic residues [active] 768494000652 substrate binding site [chemical binding]; other site 768494000653 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 768494000654 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 768494000655 dimer interface [polypeptide binding]; other site 768494000656 putative anticodon binding site; other site 768494000657 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 768494000658 motif 1; other site 768494000659 active site 768494000660 motif 2; other site 768494000661 motif 3; other site 768494000662 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 768494000663 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 768494000664 UvrB/uvrC motif; Region: UVR; pfam02151 768494000665 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 768494000666 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 768494000667 ADP binding site [chemical binding]; other site 768494000668 phosphagen binding site; other site 768494000669 substrate specificity loop; other site 768494000670 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 768494000671 Clp amino terminal domain; Region: Clp_N; pfam02861 768494000672 Clp amino terminal domain; Region: Clp_N; pfam02861 768494000673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494000674 Walker A motif; other site 768494000675 ATP binding site [chemical binding]; other site 768494000676 Walker B motif; other site 768494000677 arginine finger; other site 768494000678 UvrB/uvrC motif; Region: UVR; pfam02151 768494000679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494000680 Walker A motif; other site 768494000681 ATP binding site [chemical binding]; other site 768494000682 Walker B motif; other site 768494000683 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768494000684 DNA repair protein RadA; Provisional; Region: PRK11823 768494000685 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 768494000686 Walker A motif/ATP binding site; other site 768494000687 ATP binding site [chemical binding]; other site 768494000688 Walker B motif; other site 768494000689 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 768494000690 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 768494000691 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 768494000692 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 768494000693 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 768494000694 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 768494000695 putative active site [active] 768494000696 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 768494000697 substrate binding site; other site 768494000698 dimer interface; other site 768494000699 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 768494000700 homotrimer interaction site [polypeptide binding]; other site 768494000701 zinc binding site [ion binding]; other site 768494000702 CDP-binding sites; other site 768494000703 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 768494000704 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768494000705 active site 768494000706 HIGH motif; other site 768494000707 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768494000708 active site 768494000709 KMSKS motif; other site 768494000710 serine O-acetyltransferase; Region: cysE; TIGR01172 768494000711 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 768494000712 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 768494000713 trimer interface [polypeptide binding]; other site 768494000714 active site 768494000715 substrate binding site [chemical binding]; other site 768494000716 CoA binding site [chemical binding]; other site 768494000717 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 768494000718 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768494000719 active site 768494000720 HIGH motif; other site 768494000721 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768494000722 KMSKS motif; other site 768494000723 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 768494000724 tRNA binding surface [nucleotide binding]; other site 768494000725 anticodon binding site; other site 768494000726 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 768494000727 active site 768494000728 metal binding site [ion binding]; metal-binding site 768494000729 dimerization interface [polypeptide binding]; other site 768494000730 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 768494000731 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 768494000732 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768494000733 YacP-like NYN domain; Region: NYN_YacP; pfam05991 768494000734 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 768494000735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494000736 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 768494000737 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 768494000738 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 768494000739 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 768494000740 putative homodimer interface [polypeptide binding]; other site 768494000741 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 768494000742 heterodimer interface [polypeptide binding]; other site 768494000743 homodimer interface [polypeptide binding]; other site 768494000744 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 768494000745 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 768494000746 23S rRNA interface [nucleotide binding]; other site 768494000747 L7/L12 interface [polypeptide binding]; other site 768494000748 putative thiostrepton binding site; other site 768494000749 L25 interface [polypeptide binding]; other site 768494000750 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 768494000751 mRNA/rRNA interface [nucleotide binding]; other site 768494000752 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 768494000753 23S rRNA interface [nucleotide binding]; other site 768494000754 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 768494000755 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 768494000756 core dimer interface [polypeptide binding]; other site 768494000757 peripheral dimer interface [polypeptide binding]; other site 768494000758 L10 interface [polypeptide binding]; other site 768494000759 L11 interface [polypeptide binding]; other site 768494000760 putative EF-Tu interaction site [polypeptide binding]; other site 768494000761 putative EF-G interaction site [polypeptide binding]; other site 768494000762 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 768494000763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494000764 S-adenosylmethionine binding site [chemical binding]; other site 768494000765 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 768494000766 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 768494000767 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 768494000768 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 768494000769 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 768494000770 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 768494000771 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768494000772 RPB10 interaction site [polypeptide binding]; other site 768494000773 RPB1 interaction site [polypeptide binding]; other site 768494000774 RPB11 interaction site [polypeptide binding]; other site 768494000775 RPB3 interaction site [polypeptide binding]; other site 768494000776 RPB12 interaction site [polypeptide binding]; other site 768494000777 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 768494000778 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 768494000779 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 768494000780 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 768494000781 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 768494000782 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 768494000783 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 768494000784 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 768494000785 G-loop; other site 768494000786 DNA binding site [nucleotide binding] 768494000787 hypothetical protein; Provisional; Region: PRK06683 768494000788 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 768494000789 S17 interaction site [polypeptide binding]; other site 768494000790 S8 interaction site; other site 768494000791 16S rRNA interaction site [nucleotide binding]; other site 768494000792 streptomycin interaction site [chemical binding]; other site 768494000793 23S rRNA interaction site [nucleotide binding]; other site 768494000794 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 768494000795 30S ribosomal protein S7; Validated; Region: PRK05302 768494000796 elongation factor G; Reviewed; Region: PRK00007 768494000797 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 768494000798 G1 box; other site 768494000799 putative GEF interaction site [polypeptide binding]; other site 768494000800 GTP/Mg2+ binding site [chemical binding]; other site 768494000801 Switch I region; other site 768494000802 G2 box; other site 768494000803 G3 box; other site 768494000804 Switch II region; other site 768494000805 G4 box; other site 768494000806 G5 box; other site 768494000807 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768494000808 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 768494000809 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768494000810 elongation factor Tu; Reviewed; Region: PRK00049 768494000811 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768494000812 G1 box; other site 768494000813 GEF interaction site [polypeptide binding]; other site 768494000814 GTP/Mg2+ binding site [chemical binding]; other site 768494000815 Switch I region; other site 768494000816 G2 box; other site 768494000817 G3 box; other site 768494000818 Switch II region; other site 768494000819 G4 box; other site 768494000820 G5 box; other site 768494000821 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768494000822 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768494000823 Antibiotic Binding Site [chemical binding]; other site 768494000824 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 768494000825 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 768494000826 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 768494000827 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 768494000828 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 768494000829 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 768494000830 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 768494000831 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 768494000832 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 768494000833 putative translocon binding site; other site 768494000834 protein-rRNA interface [nucleotide binding]; other site 768494000835 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 768494000836 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 768494000837 G-X-X-G motif; other site 768494000838 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 768494000839 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 768494000840 23S rRNA interface [nucleotide binding]; other site 768494000841 5S rRNA interface [nucleotide binding]; other site 768494000842 putative antibiotic binding site [chemical binding]; other site 768494000843 L25 interface [polypeptide binding]; other site 768494000844 L27 interface [polypeptide binding]; other site 768494000845 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 768494000846 23S rRNA interface [nucleotide binding]; other site 768494000847 putative translocon interaction site; other site 768494000848 signal recognition particle (SRP54) interaction site; other site 768494000849 L23 interface [polypeptide binding]; other site 768494000850 trigger factor interaction site; other site 768494000851 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 768494000852 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 768494000853 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 768494000854 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 768494000855 RNA binding site [nucleotide binding]; other site 768494000856 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 768494000857 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 768494000858 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 768494000859 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 768494000860 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 768494000861 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 768494000862 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768494000863 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768494000864 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 768494000865 5S rRNA interface [nucleotide binding]; other site 768494000866 L27 interface [polypeptide binding]; other site 768494000867 23S rRNA interface [nucleotide binding]; other site 768494000868 L5 interface [polypeptide binding]; other site 768494000869 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 768494000870 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 768494000871 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 768494000872 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 768494000873 23S rRNA binding site [nucleotide binding]; other site 768494000874 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 768494000875 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 768494000876 SecY translocase; Region: SecY; pfam00344 768494000877 adenylate kinase; Reviewed; Region: adk; PRK00279 768494000878 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 768494000879 AMP-binding site [chemical binding]; other site 768494000880 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 768494000881 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768494000882 active site 768494000883 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 768494000884 rRNA binding site [nucleotide binding]; other site 768494000885 predicted 30S ribosome binding site; other site 768494000886 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 768494000887 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 768494000888 30S ribosomal protein S13; Region: bact_S13; TIGR03631 768494000889 30S ribosomal protein S11; Validated; Region: PRK05309 768494000890 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 768494000891 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 768494000892 alphaNTD - beta interaction site [polypeptide binding]; other site 768494000893 alphaNTD homodimer interface [polypeptide binding]; other site 768494000894 alphaNTD - beta' interaction site [polypeptide binding]; other site 768494000895 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 768494000896 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 768494000897 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 768494000898 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 768494000899 Walker A/P-loop; other site 768494000900 ATP binding site [chemical binding]; other site 768494000901 Q-loop/lid; other site 768494000902 ABC transporter signature motif; other site 768494000903 Walker B; other site 768494000904 D-loop; other site 768494000905 H-loop/switch region; other site 768494000906 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 768494000907 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 768494000908 Walker A/P-loop; other site 768494000909 ATP binding site [chemical binding]; other site 768494000910 Q-loop/lid; other site 768494000911 ABC transporter signature motif; other site 768494000912 Walker B; other site 768494000913 D-loop; other site 768494000914 H-loop/switch region; other site 768494000915 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 768494000916 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 768494000917 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 768494000918 dimerization interface 3.5A [polypeptide binding]; other site 768494000919 active site 768494000920 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 768494000921 23S rRNA interface [nucleotide binding]; other site 768494000922 L3 interface [polypeptide binding]; other site 768494000923 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 768494000924 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 768494000925 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 768494000926 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768494000927 active site 768494000928 metal binding site [ion binding]; metal-binding site 768494000929 Domain of unknown function DUF59; Region: DUF59; pfam01883 768494000930 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 768494000931 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 768494000932 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 768494000933 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 768494000934 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 768494000935 NodB motif; other site 768494000936 putative active site [active] 768494000937 putative catalytic site [active] 768494000938 Glycerate kinase family; Region: Gly_kinase; cl00841 768494000939 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 768494000940 Arginase family; Region: Arginase; cd09989 768494000941 agmatinase; Region: agmatinase; TIGR01230 768494000942 active site 768494000943 Mn binding site [ion binding]; other site 768494000944 oligomer interface [polypeptide binding]; other site 768494000945 Uncharacterized conserved protein [Function unknown]; Region: COG1624 768494000946 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 768494000947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 768494000948 YbbR-like protein; Region: YbbR; pfam07949 768494000949 YbbR-like protein; Region: YbbR; pfam07949 768494000950 YbbR-like protein; Region: YbbR; pfam07949 768494000951 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 768494000952 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 768494000953 active site 768494000954 substrate binding site [chemical binding]; other site 768494000955 metal binding site [ion binding]; metal-binding site 768494000956 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 768494000957 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 768494000958 glutaminase active site [active] 768494000959 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 768494000960 dimer interface [polypeptide binding]; other site 768494000961 active site 768494000962 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 768494000963 dimer interface [polypeptide binding]; other site 768494000964 active site 768494000965 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768494000966 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768494000967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494000968 DNA-binding site [nucleotide binding]; DNA binding site 768494000969 FCD domain; Region: FCD; pfam07729 768494000970 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768494000971 nucleotide binding site [chemical binding]; other site 768494000972 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 768494000973 N- and C-terminal domain interface [polypeptide binding]; other site 768494000974 active site 768494000975 carbohydrate binding site [chemical binding]; other site 768494000976 ATP binding site [chemical binding]; other site 768494000977 fructuronate transporter; Provisional; Region: PRK10034; cl15264 768494000978 gluconate transporter; Region: gntP; TIGR00791 768494000979 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768494000980 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 768494000981 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 768494000982 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 768494000983 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768494000984 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 768494000985 DoxX; Region: DoxX; cl17842 768494000986 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 768494000987 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 768494000988 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 768494000989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494000990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494000991 DNA binding residues [nucleotide binding] 768494000992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494000993 classical (c) SDRs; Region: SDR_c; cd05233 768494000994 NAD(P) binding site [chemical binding]; other site 768494000995 active site 768494000996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494000997 ABC-ATPase subunit interface; other site 768494000998 potential frameshift: common BLAST hit: gi|301051908|ref|YP_003790119.1| ABC transporter ATP-binding protein 768494000999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494001000 Walker B; other site 768494001001 D-loop; other site 768494001002 H-loop/switch region; other site 768494001003 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768494001004 NIL domain; Region: NIL; pfam09383 768494001005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494001006 Walker A/P-loop; other site 768494001007 ATP binding site [chemical binding]; other site 768494001008 Q-loop/lid; other site 768494001009 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768494001010 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768494001011 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768494001012 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 768494001013 putative NAD(P) binding site [chemical binding]; other site 768494001014 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 768494001015 FAD binding domain; Region: FAD_binding_4; pfam01565 768494001016 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494001017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494001018 putative substrate translocation pore; other site 768494001019 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 768494001020 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 768494001021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494001022 putative substrate translocation pore; other site 768494001023 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 768494001024 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 768494001025 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768494001026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494001027 dimer interface [polypeptide binding]; other site 768494001028 conserved gate region; other site 768494001029 putative PBP binding loops; other site 768494001030 ABC-ATPase subunit interface; other site 768494001031 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768494001032 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768494001033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494001034 dimer interface [polypeptide binding]; other site 768494001035 conserved gate region; other site 768494001036 putative PBP binding loops; other site 768494001037 ABC-ATPase subunit interface; other site 768494001038 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768494001039 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768494001040 Walker A/P-loop; other site 768494001041 ATP binding site [chemical binding]; other site 768494001042 Q-loop/lid; other site 768494001043 ABC transporter signature motif; other site 768494001044 Walker B; other site 768494001045 D-loop; other site 768494001046 H-loop/switch region; other site 768494001047 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768494001048 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 768494001049 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768494001050 Walker A/P-loop; other site 768494001051 ATP binding site [chemical binding]; other site 768494001052 Q-loop/lid; other site 768494001053 ABC transporter signature motif; other site 768494001054 Walker B; other site 768494001055 D-loop; other site 768494001056 H-loop/switch region; other site 768494001057 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 768494001058 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768494001059 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494001060 peptide binding site [polypeptide binding]; other site 768494001061 YusW-like protein; Region: YusW; pfam14039 768494001062 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494001063 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768494001064 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494001065 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 768494001066 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768494001067 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494001068 peptide binding site [polypeptide binding]; other site 768494001069 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768494001070 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494001071 peptide binding site [polypeptide binding]; other site 768494001072 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768494001073 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768494001074 active site 768494001075 catalytic tetrad [active] 768494001076 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 768494001077 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 768494001078 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 768494001079 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 768494001080 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768494001081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494001082 dimer interface [polypeptide binding]; other site 768494001083 conserved gate region; other site 768494001084 putative PBP binding loops; other site 768494001085 ABC-ATPase subunit interface; other site 768494001086 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 768494001087 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768494001088 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 768494001089 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768494001090 DNA binding domain, excisionase family; Region: excise; TIGR01764 768494001091 PBP superfamily domain; Region: PBP_like; pfam12727 768494001092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768494001093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494001094 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 768494001095 putative dimerization interface [polypeptide binding]; other site 768494001096 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768494001097 EamA-like transporter family; Region: EamA; pfam00892 768494001098 YrzO-like protein; Region: YrzO; pfam14142 768494001099 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768494001100 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768494001101 putative acyl-acceptor binding pocket; other site 768494001102 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768494001103 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768494001104 DNA binding site [nucleotide binding] 768494001105 domain linker motif; other site 768494001106 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 768494001107 putative ligand binding site [chemical binding]; other site 768494001108 putative dimerization interface [polypeptide binding]; other site 768494001109 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768494001110 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494001111 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494001112 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768494001113 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 768494001114 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768494001115 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 768494001116 active site 768494001117 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 768494001118 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 768494001119 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 768494001120 lysozyme catalytic site [active] 768494001121 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 768494001122 nucleotide binding site/active site [active] 768494001123 HIT family signature motif; other site 768494001124 catalytic residue [active] 768494001125 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768494001126 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494001127 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494001128 ABC transporter; Region: ABC_tran_2; pfam12848 768494001129 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494001130 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768494001131 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 768494001132 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768494001133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494001134 dimer interface [polypeptide binding]; other site 768494001135 conserved gate region; other site 768494001136 putative PBP binding loops; other site 768494001137 ABC-ATPase subunit interface; other site 768494001138 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768494001139 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768494001140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494001141 dimer interface [polypeptide binding]; other site 768494001142 conserved gate region; other site 768494001143 putative PBP binding loops; other site 768494001144 ABC-ATPase subunit interface; other site 768494001145 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768494001146 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768494001147 Walker A/P-loop; other site 768494001148 ATP binding site [chemical binding]; other site 768494001149 Q-loop/lid; other site 768494001150 ABC transporter signature motif; other site 768494001151 Walker B; other site 768494001152 D-loop; other site 768494001153 H-loop/switch region; other site 768494001154 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768494001155 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 768494001156 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768494001157 Walker A/P-loop; other site 768494001158 ATP binding site [chemical binding]; other site 768494001159 Q-loop/lid; other site 768494001160 ABC transporter signature motif; other site 768494001161 Walker B; other site 768494001162 D-loop; other site 768494001163 H-loop/switch region; other site 768494001164 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768494001165 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768494001166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494001167 motif II; other site 768494001168 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 768494001169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494001170 active site 768494001171 motif I; other site 768494001172 motif II; other site 768494001173 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 768494001174 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 768494001175 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 768494001176 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 768494001177 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 768494001178 dimer interface [polypeptide binding]; other site 768494001179 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 768494001180 active site 768494001181 Fe binding site [ion binding]; other site 768494001182 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768494001183 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768494001184 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 768494001185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494001186 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494001187 putative substrate translocation pore; other site 768494001188 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768494001189 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768494001190 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 768494001191 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768494001192 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768494001193 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768494001194 helicase 45; Provisional; Region: PTZ00424 768494001195 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768494001196 ATP binding site [chemical binding]; other site 768494001197 Mg++ binding site [ion binding]; other site 768494001198 motif III; other site 768494001199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494001200 nucleotide binding region [chemical binding]; other site 768494001201 ATP-binding site [chemical binding]; other site 768494001202 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 768494001203 Rhomboid family; Region: Rhomboid; pfam01694 768494001204 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 768494001205 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 768494001206 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 768494001207 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 768494001208 alanine racemase; Reviewed; Region: alr; PRK00053 768494001209 active site 768494001210 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768494001211 dimer interface [polypeptide binding]; other site 768494001212 substrate binding site [chemical binding]; other site 768494001213 catalytic residues [active] 768494001214 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 768494001215 PemK-like protein; Region: PemK; pfam02452 768494001216 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 768494001217 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 768494001218 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 768494001219 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 768494001220 RNA binding site [nucleotide binding]; other site 768494001221 hypothetical protein; Provisional; Region: PRK04351 768494001222 SprT homologues; Region: SprT; cl01182 768494001223 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 768494001224 Glycoprotease family; Region: Peptidase_M22; pfam00814 768494001225 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 768494001226 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 768494001227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494001228 Coenzyme A binding pocket [chemical binding]; other site 768494001229 UGMP family protein; Validated; Region: PRK09604 768494001230 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 768494001231 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768494001232 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768494001233 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494001234 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494001235 ABC transporter; Region: ABC_tran_2; pfam12848 768494001236 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494001237 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 768494001238 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 768494001239 CoA binding domain; Region: CoA_binding; pfam02629 768494001240 CAAX protease self-immunity; Region: Abi; pfam02517 768494001241 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 768494001242 oligomerisation interface [polypeptide binding]; other site 768494001243 mobile loop; other site 768494001244 roof hairpin; other site 768494001245 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 768494001246 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 768494001247 ring oligomerisation interface [polypeptide binding]; other site 768494001248 ATP/Mg binding site [chemical binding]; other site 768494001249 stacking interactions; other site 768494001250 hinge regions; other site 768494001251 GMP synthase; Reviewed; Region: guaA; PRK00074 768494001252 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 768494001253 AMP/PPi binding site [chemical binding]; other site 768494001254 candidate oxyanion hole; other site 768494001255 catalytic triad [active] 768494001256 potential glutamine specificity residues [chemical binding]; other site 768494001257 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 768494001258 ATP Binding subdomain [chemical binding]; other site 768494001259 Ligand Binding sites [chemical binding]; other site 768494001260 Dimerization subdomain; other site 768494001261 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768494001262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494001263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494001264 active site 768494001265 phosphorylation site [posttranslational modification] 768494001266 intermolecular recognition site; other site 768494001267 dimerization interface [polypeptide binding]; other site 768494001268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494001269 DNA binding site [nucleotide binding] 768494001270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494001271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494001272 dimerization interface [polypeptide binding]; other site 768494001273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494001274 dimer interface [polypeptide binding]; other site 768494001275 phosphorylation site [posttranslational modification] 768494001276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494001277 ATP binding site [chemical binding]; other site 768494001278 Mg2+ binding site [ion binding]; other site 768494001279 G-X-G motif; other site 768494001280 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 768494001281 putative ligand binding site [chemical binding]; other site 768494001282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494001283 S-adenosylmethionine binding site [chemical binding]; other site 768494001284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494001285 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 768494001286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494001287 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768494001288 NAD(P) binding site [chemical binding]; other site 768494001289 active site 768494001290 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768494001291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494001292 S-adenosylmethionine binding site [chemical binding]; other site 768494001293 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494001294 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768494001295 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768494001296 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768494001297 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768494001298 active site 768494001299 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 768494001300 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 768494001301 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 768494001302 NAD binding site [chemical binding]; other site 768494001303 ATP-grasp domain; Region: ATP-grasp; pfam02222 768494001304 adenylosuccinate lyase; Provisional; Region: PRK07492 768494001305 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 768494001306 tetramer interface [polypeptide binding]; other site 768494001307 active site 768494001308 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 768494001309 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 768494001310 ATP binding site [chemical binding]; other site 768494001311 active site 768494001312 substrate binding site [chemical binding]; other site 768494001313 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 768494001314 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 768494001315 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 768494001316 putative active site [active] 768494001317 catalytic triad [active] 768494001318 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 768494001319 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 768494001320 dimerization interface [polypeptide binding]; other site 768494001321 ATP binding site [chemical binding]; other site 768494001322 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 768494001323 dimerization interface [polypeptide binding]; other site 768494001324 ATP binding site [chemical binding]; other site 768494001325 amidophosphoribosyltransferase; Provisional; Region: PRK06781 768494001326 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 768494001327 active site 768494001328 tetramer interface [polypeptide binding]; other site 768494001329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768494001330 active site 768494001331 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 768494001332 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 768494001333 dimerization interface [polypeptide binding]; other site 768494001334 putative ATP binding site [chemical binding]; other site 768494001335 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 768494001336 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 768494001337 active site 768494001338 substrate binding site [chemical binding]; other site 768494001339 cosubstrate binding site; other site 768494001340 catalytic site [active] 768494001341 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 768494001342 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 768494001343 purine monophosphate binding site [chemical binding]; other site 768494001344 dimer interface [polypeptide binding]; other site 768494001345 putative catalytic residues [active] 768494001346 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 768494001347 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 768494001348 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 768494001349 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 768494001350 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 768494001351 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 768494001352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 768494001353 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 768494001354 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 768494001355 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 768494001356 PcrB family; Region: PcrB; pfam01884 768494001357 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 768494001358 substrate binding site [chemical binding]; other site 768494001359 putative active site [active] 768494001360 dimer interface [polypeptide binding]; other site 768494001361 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 768494001362 Part of AAA domain; Region: AAA_19; pfam13245 768494001363 Family description; Region: UvrD_C_2; pfam13538 768494001364 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 768494001365 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 768494001366 nucleotide binding pocket [chemical binding]; other site 768494001367 K-X-D-G motif; other site 768494001368 catalytic site [active] 768494001369 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 768494001370 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 768494001371 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 768494001372 Dimer interface [polypeptide binding]; other site 768494001373 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 768494001374 putative dimer interface [polypeptide binding]; other site 768494001375 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 768494001376 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 768494001377 putative dimer interface [polypeptide binding]; other site 768494001378 hypothetical protein; Provisional; Region: PRK10621 768494001379 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768494001380 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 768494001381 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 768494001382 Glutamate binding site [chemical binding]; other site 768494001383 homodimer interface [polypeptide binding]; other site 768494001384 NAD binding site [chemical binding]; other site 768494001385 catalytic residues [active] 768494001386 Isochorismatase family; Region: Isochorismatase; pfam00857 768494001387 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768494001388 catalytic triad [active] 768494001389 conserved cis-peptide bond; other site 768494001390 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768494001391 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768494001392 Walker A/P-loop; other site 768494001393 ATP binding site [chemical binding]; other site 768494001394 Q-loop/lid; other site 768494001395 ABC transporter signature motif; other site 768494001396 Walker B; other site 768494001397 D-loop; other site 768494001398 H-loop/switch region; other site 768494001399 NIL domain; Region: NIL; pfam09383 768494001400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494001401 dimer interface [polypeptide binding]; other site 768494001402 conserved gate region; other site 768494001403 ABC-ATPase subunit interface; other site 768494001404 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768494001405 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768494001406 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 768494001407 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 768494001408 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 768494001409 putative dimer interface [polypeptide binding]; other site 768494001410 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 768494001411 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 768494001412 P loop; other site 768494001413 Nucleotide binding site [chemical binding]; other site 768494001414 DTAP/Switch II; other site 768494001415 Switch I; other site 768494001416 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494001417 MarR family; Region: MarR; pfam01047 768494001418 MarR family; Region: MarR_2; cl17246 768494001419 yiaA/B two helix domain; Region: YiaAB; pfam05360 768494001420 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 768494001421 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 768494001422 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 768494001423 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 768494001424 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 768494001425 GatB domain; Region: GatB_Yqey; pfam02637 768494001426 putative lipid kinase; Reviewed; Region: PRK13337 768494001427 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 768494001428 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 768494001429 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494001430 motif II; other site 768494001431 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 768494001432 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768494001433 inhibitor-cofactor binding pocket; inhibition site 768494001434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494001435 catalytic residue [active] 768494001436 PAS domain; Region: PAS_9; pfam13426 768494001437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494001438 putative active site [active] 768494001439 heme pocket [chemical binding]; other site 768494001440 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768494001441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494001442 Walker A motif; other site 768494001443 ATP binding site [chemical binding]; other site 768494001444 Walker B motif; other site 768494001445 arginine finger; other site 768494001446 succinic semialdehyde dehydrogenase; Region: PLN02278 768494001447 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768494001448 tetramerization interface [polypeptide binding]; other site 768494001449 NAD(P) binding site [chemical binding]; other site 768494001450 catalytic residues [active] 768494001451 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 768494001452 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 768494001453 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 768494001454 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 768494001455 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 768494001456 putative active site [active] 768494001457 putative metal binding site [ion binding]; other site 768494001458 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 768494001459 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 768494001460 putative active site [active] 768494001461 putative metal binding site [ion binding]; other site 768494001462 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768494001463 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768494001464 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768494001465 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 768494001466 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 768494001467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494001468 S-adenosylmethionine binding site [chemical binding]; other site 768494001469 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 768494001470 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768494001471 FMN binding site [chemical binding]; other site 768494001472 active site 768494001473 catalytic residues [active] 768494001474 substrate binding site [chemical binding]; other site 768494001475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 768494001476 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 768494001477 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 768494001478 Protein of unknown function DUF45; Region: DUF45; pfam01863 768494001479 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768494001480 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 768494001481 active site 768494001482 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 768494001483 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768494001484 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 768494001485 metal binding site [ion binding]; metal-binding site 768494001486 putative dimer interface [polypeptide binding]; other site 768494001487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494001488 S-adenosylmethionine binding site [chemical binding]; other site 768494001489 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 768494001490 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 768494001491 catalytic residue [active] 768494001492 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 768494001493 catalytic residues [active] 768494001494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768494001495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494001496 peroxiredoxin; Region: AhpC; TIGR03137 768494001497 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 768494001498 dimer interface [polypeptide binding]; other site 768494001499 decamer (pentamer of dimers) interface [polypeptide binding]; other site 768494001500 catalytic triad [active] 768494001501 peroxidatic and resolving cysteines [active] 768494001502 5-methylribose kinase; Reviewed; Region: PRK12396 768494001503 Phosphotransferase enzyme family; Region: APH; pfam01636 768494001504 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 768494001505 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 768494001506 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 768494001507 intersubunit interface [polypeptide binding]; other site 768494001508 active site 768494001509 Zn2+ binding site [ion binding]; other site 768494001510 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768494001511 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494001512 ABC-ATPase subunit interface; other site 768494001513 dimer interface [polypeptide binding]; other site 768494001514 putative PBP binding regions; other site 768494001515 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768494001516 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494001517 ABC-ATPase subunit interface; other site 768494001518 dimer interface [polypeptide binding]; other site 768494001519 putative PBP binding regions; other site 768494001520 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768494001521 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 768494001522 putative ligand binding residues [chemical binding]; other site 768494001523 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 768494001524 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768494001525 DNA binding domain, excisionase family; Region: excise; TIGR01764 768494001526 Sm and related proteins; Region: Sm_like; cl00259 768494001527 Sm1 motif; other site 768494001528 RNA binding site [nucleotide binding]; other site 768494001529 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 768494001530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494001531 ATP binding site [chemical binding]; other site 768494001532 G-X-G motif; other site 768494001533 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 768494001534 hypothetical protein; Provisional; Region: PRK06851 768494001535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 768494001536 Walker A motif; other site 768494001537 ATP binding site [chemical binding]; other site 768494001538 NTPase; Region: NTPase_1; cl17478 768494001539 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 768494001540 benzoate transport; Region: 2A0115; TIGR00895 768494001541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494001542 putative substrate translocation pore; other site 768494001543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494001544 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768494001545 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768494001546 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 768494001547 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 768494001548 [2Fe-2S] cluster binding site [ion binding]; other site 768494001549 Fatty acid desaturase; Region: FA_desaturase; pfam00487 768494001550 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 768494001551 putative di-iron ligands [ion binding]; other site 768494001552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494001553 dimer interface [polypeptide binding]; other site 768494001554 conserved gate region; other site 768494001555 putative PBP binding loops; other site 768494001556 ABC-ATPase subunit interface; other site 768494001557 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768494001558 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768494001559 substrate binding pocket [chemical binding]; other site 768494001560 membrane-bound complex binding site; other site 768494001561 hinge residues; other site 768494001562 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768494001563 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768494001564 Walker A/P-loop; other site 768494001565 ATP binding site [chemical binding]; other site 768494001566 Q-loop/lid; other site 768494001567 ABC transporter signature motif; other site 768494001568 Walker B; other site 768494001569 D-loop; other site 768494001570 H-loop/switch region; other site 768494001571 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 768494001572 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 768494001573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494001574 dimerization interface [polypeptide binding]; other site 768494001575 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494001576 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494001577 dimer interface [polypeptide binding]; other site 768494001578 putative CheW interface [polypeptide binding]; other site 768494001579 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 768494001580 HAMP domain; Region: HAMP; pfam00672 768494001581 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494001582 dimer interface [polypeptide binding]; other site 768494001583 putative CheW interface [polypeptide binding]; other site 768494001584 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768494001585 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768494001586 Ca binding site [ion binding]; other site 768494001587 active site 768494001588 catalytic site [active] 768494001589 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768494001590 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 768494001591 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768494001592 active site turn [active] 768494001593 phosphorylation site [posttranslational modification] 768494001594 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 768494001595 putative catalytic site [active] 768494001596 putative metal binding site [ion binding]; other site 768494001597 putative phosphate binding site [ion binding]; other site 768494001598 Predicted membrane protein [Function unknown]; Region: COG1511 768494001599 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 768494001600 Predicted membrane protein [Function unknown]; Region: COG1511 768494001601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494001602 DNA topoisomerase III; Provisional; Region: PRK07726 768494001603 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768494001604 active site 768494001605 putative interdomain interaction site [polypeptide binding]; other site 768494001606 putative metal-binding site [ion binding]; other site 768494001607 putative nucleotide binding site [chemical binding]; other site 768494001608 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768494001609 domain I; other site 768494001610 DNA binding groove [nucleotide binding] 768494001611 phosphate binding site [ion binding]; other site 768494001612 domain II; other site 768494001613 domain III; other site 768494001614 nucleotide binding site [chemical binding]; other site 768494001615 catalytic site [active] 768494001616 domain IV; other site 768494001617 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 768494001618 substrate binding site [chemical binding]; other site 768494001619 multimerization interface [polypeptide binding]; other site 768494001620 ATP binding site [chemical binding]; other site 768494001621 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 768494001622 thiamine phosphate binding site [chemical binding]; other site 768494001623 active site 768494001624 pyrophosphate binding site [ion binding]; other site 768494001625 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 768494001626 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 768494001627 HAMP domain; Region: HAMP; pfam00672 768494001628 dimerization interface [polypeptide binding]; other site 768494001629 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768494001630 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494001631 dimer interface [polypeptide binding]; other site 768494001632 putative CheW interface [polypeptide binding]; other site 768494001633 Domain of unknown function DUF77; Region: DUF77; pfam01910 768494001634 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768494001635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494001636 dimer interface [polypeptide binding]; other site 768494001637 conserved gate region; other site 768494001638 putative PBP binding loops; other site 768494001639 ABC-ATPase subunit interface; other site 768494001640 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 768494001641 NMT1/THI5 like; Region: NMT1; pfam09084 768494001642 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768494001643 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768494001644 Walker A/P-loop; other site 768494001645 ATP binding site [chemical binding]; other site 768494001646 Q-loop/lid; other site 768494001647 ABC transporter signature motif; other site 768494001648 Walker B; other site 768494001649 D-loop; other site 768494001650 H-loop/switch region; other site 768494001651 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768494001652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494001653 Walker A/P-loop; other site 768494001654 ATP binding site [chemical binding]; other site 768494001655 Q-loop/lid; other site 768494001656 ABC transporter signature motif; other site 768494001657 Walker B; other site 768494001658 D-loop; other site 768494001659 H-loop/switch region; other site 768494001660 ABC transporter; Region: ABC_tran_2; pfam12848 768494001661 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494001662 Glyco_18 domain; Region: Glyco_18; smart00636 768494001663 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 768494001664 active site 768494001665 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768494001666 Interdomain contacts; other site 768494001667 Cytokine receptor motif; other site 768494001668 CBD_II domain; Region: CBD_II; smart00637 768494001669 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 768494001670 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768494001671 catalytic residues [active] 768494001672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494001673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494001674 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 768494001675 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494001676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494001677 putative substrate translocation pore; other site 768494001678 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494001679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494001680 non-specific DNA binding site [nucleotide binding]; other site 768494001681 salt bridge; other site 768494001682 sequence-specific DNA binding site [nucleotide binding]; other site 768494001683 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 768494001684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494001685 putative substrate translocation pore; other site 768494001686 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 768494001687 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 768494001688 YesK-like protein; Region: YesK; pfam14150 768494001689 prolyl-tRNA synthetase; Provisional; Region: PRK08661 768494001690 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 768494001691 dimer interface [polypeptide binding]; other site 768494001692 motif 1; other site 768494001693 active site 768494001694 motif 2; other site 768494001695 motif 3; other site 768494001696 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 768494001697 anticodon binding site; other site 768494001698 zinc-binding site [ion binding]; other site 768494001699 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768494001700 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768494001701 nucleotide binding site [chemical binding]; other site 768494001702 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 768494001703 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 768494001704 putative metal binding site [ion binding]; other site 768494001705 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 768494001706 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 768494001707 putative metal binding site [ion binding]; other site 768494001708 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 768494001709 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 768494001710 putative metal binding site [ion binding]; other site 768494001711 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 768494001712 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 768494001713 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 768494001714 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 768494001715 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 768494001716 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768494001717 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768494001718 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 768494001719 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768494001720 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 768494001721 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 768494001722 Low molecular weight phosphatase family; Region: LMWPc; cd00115 768494001723 active site 768494001724 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 768494001725 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 768494001726 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 768494001727 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768494001728 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768494001729 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768494001730 EamA-like transporter family; Region: EamA; pfam00892 768494001731 EamA-like transporter family; Region: EamA; pfam00892 768494001732 YhhN-like protein; Region: YhhN; pfam07947 768494001733 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 768494001734 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768494001735 Catalytic site [active] 768494001736 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768494001737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494001738 binding surface 768494001739 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768494001740 TPR motif; other site 768494001741 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768494001742 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768494001743 Predicted membrane protein [Function unknown]; Region: COG2510 768494001744 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 768494001745 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 768494001746 calcium/proton exchanger (cax); Region: cax; TIGR00378 768494001747 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768494001748 YfkD-like protein; Region: YfkD; pfam14167 768494001749 Radical SAM superfamily; Region: Radical_SAM; pfam04055 768494001750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494001751 FeS/SAM binding site; other site 768494001752 YfkB-like domain; Region: YfkB; pfam08756 768494001753 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 768494001754 Fumarase C-terminus; Region: Fumerase_C; pfam05683 768494001755 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 768494001756 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 768494001757 NodB motif; other site 768494001758 active site 768494001759 catalytic site [active] 768494001760 Cd binding site [ion binding]; other site 768494001761 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768494001762 endonuclease III; Region: ENDO3c; smart00478 768494001763 minor groove reading motif; other site 768494001764 helix-hairpin-helix signature motif; other site 768494001765 substrate binding pocket [chemical binding]; other site 768494001766 active site 768494001767 TRAM domain; Region: TRAM; pfam01938 768494001768 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 768494001769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494001770 S-adenosylmethionine binding site [chemical binding]; other site 768494001771 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 768494001772 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 768494001773 Int/Topo IB signature motif; other site 768494001774 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494001775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494001776 non-specific DNA binding site [nucleotide binding]; other site 768494001777 salt bridge; other site 768494001778 sequence-specific DNA binding site [nucleotide binding]; other site 768494001779 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494001780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494001781 non-specific DNA binding site [nucleotide binding]; other site 768494001782 salt bridge; other site 768494001783 sequence-specific DNA binding site [nucleotide binding]; other site 768494001784 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 768494001785 ORF6C domain; Region: ORF6C; pfam10552 768494001786 Helix-turn-helix domain; Region: HTH_17; pfam12728 768494001787 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 768494001788 hypothetical protein; Validated; Region: PRK08116 768494001789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494001790 Walker A motif; other site 768494001791 ATP binding site [chemical binding]; other site 768494001792 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 768494001793 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 768494001794 putative metal binding site [ion binding]; other site 768494001795 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 768494001796 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 768494001797 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768494001798 DNA binding site [nucleotide binding] 768494001799 active site 768494001800 Int/Topo IB signature motif; other site 768494001801 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 768494001802 Phage-related protein [Function unknown]; Region: COG4695; cl01923 768494001803 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 768494001804 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 768494001805 Phage capsid family; Region: Phage_capsid; pfam05065 768494001806 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 768494001807 oligomerization interface [polypeptide binding]; other site 768494001808 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 768494001809 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 768494001810 Domain of unknown function (DUF947); Region: DUF947; pfam06102 768494001811 Phage-related protein [Function unknown]; Region: COG4722 768494001812 Phage tail protein; Region: Sipho_tail; pfam05709 768494001813 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 768494001814 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 768494001815 Haemolysin XhlA; Region: XhlA; pfam10779 768494001816 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 768494001817 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 768494001818 active site 768494001819 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 768494001820 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 768494001821 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 768494001822 dimerization interface 3.5A [polypeptide binding]; other site 768494001823 active site 768494001824 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 768494001825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494001826 Walker A motif; other site 768494001827 ATP binding site [chemical binding]; other site 768494001828 Walker B motif; other site 768494001829 arginine finger; other site 768494001830 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768494001831 hypothetical protein; Validated; Region: PRK06748 768494001832 S-methylmethionine transporter; Provisional; Region: PRK11387 768494001833 acetylornithine deacetylase; Validated; Region: PRK08596 768494001834 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 768494001835 metal binding site [ion binding]; metal-binding site 768494001836 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494001837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494001838 non-specific DNA binding site [nucleotide binding]; other site 768494001839 salt bridge; other site 768494001840 sequence-specific DNA binding site [nucleotide binding]; other site 768494001841 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 768494001842 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 768494001843 Domain of unknown function DUF; Region: DUF204; pfam02659 768494001844 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 768494001845 glutaminase A; Region: Gln_ase; TIGR03814 768494001846 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 768494001847 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768494001848 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 768494001849 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768494001850 active site turn [active] 768494001851 phosphorylation site [posttranslational modification] 768494001852 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494001853 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494001854 Sm and related proteins; Region: Sm_like; cl00259 768494001855 heptamer interface [polypeptide binding]; other site 768494001856 Sm1 motif; other site 768494001857 hexamer interface [polypeptide binding]; other site 768494001858 RNA binding site [nucleotide binding]; other site 768494001859 Sm2 motif; other site 768494001860 Sm and related proteins; Region: Sm_like; cl00259 768494001861 heptamer interface [polypeptide binding]; other site 768494001862 Sm1 motif; other site 768494001863 hexamer interface [polypeptide binding]; other site 768494001864 RNA binding site [nucleotide binding]; other site 768494001865 Sm2 motif; other site 768494001866 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 768494001867 Ligand binding site; other site 768494001868 Putative Catalytic site; other site 768494001869 DXD motif; other site 768494001870 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768494001871 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494001872 active site 768494001873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494001874 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768494001875 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 768494001876 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768494001877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494001878 NAD(P) binding site [chemical binding]; other site 768494001879 active site 768494001880 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494001881 active site 768494001882 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768494001883 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494001884 active site 768494001885 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 768494001886 Pyruvate formate lyase 1; Region: PFL1; cd01678 768494001887 coenzyme A binding site [chemical binding]; other site 768494001888 active site 768494001889 catalytic residues [active] 768494001890 glycine loop; other site 768494001891 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 768494001892 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494001893 FeS/SAM binding site; other site 768494001894 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 768494001895 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 768494001896 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768494001897 YfhE-like protein; Region: YfhE; pfam14152 768494001898 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494001899 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 768494001900 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 768494001901 active site 768494001902 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 768494001903 TIGR01777 family protein; Region: yfcH 768494001904 putative NAD(P) binding site [chemical binding]; other site 768494001905 putative active site [active] 768494001906 recombination regulator RecX; Provisional; Region: recX; PRK14135 768494001907 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 768494001908 YpzG-like protein; Region: YpzG; pfam14139 768494001909 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 768494001910 WVELL protein; Region: WVELL; pfam14043 768494001911 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 768494001912 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 768494001913 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768494001914 minor groove reading motif; other site 768494001915 helix-hairpin-helix signature motif; other site 768494001916 substrate binding pocket [chemical binding]; other site 768494001917 active site 768494001918 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 768494001919 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 768494001920 DNA binding and oxoG recognition site [nucleotide binding] 768494001921 YgaB-like protein; Region: YgaB; pfam14182 768494001922 hypothetical protein; Provisional; Region: PRK13662 768494001923 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768494001924 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494001925 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 768494001926 Walker A/P-loop; other site 768494001927 ATP binding site [chemical binding]; other site 768494001928 Q-loop/lid; other site 768494001929 ABC transporter signature motif; other site 768494001930 Walker B; other site 768494001931 D-loop; other site 768494001932 H-loop/switch region; other site 768494001933 Predicted membrane protein [Function unknown]; Region: COG4129 768494001934 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 768494001935 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 768494001936 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 768494001937 active site 768494001938 dimer interface [polypeptide binding]; other site 768494001939 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 768494001940 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768494001941 active site 768494001942 FMN binding site [chemical binding]; other site 768494001943 substrate binding site [chemical binding]; other site 768494001944 3Fe-4S cluster binding site [ion binding]; other site 768494001945 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 768494001946 domain_subunit interface; other site 768494001947 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 768494001948 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768494001949 inhibitor-cofactor binding pocket; inhibition site 768494001950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494001951 catalytic residue [active] 768494001952 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 768494001953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494001954 Walker A/P-loop; other site 768494001955 ATP binding site [chemical binding]; other site 768494001956 Q-loop/lid; other site 768494001957 ABC transporter signature motif; other site 768494001958 Walker B; other site 768494001959 D-loop; other site 768494001960 H-loop/switch region; other site 768494001961 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 768494001962 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 768494001963 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 768494001964 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 768494001965 Ion channel; Region: Ion_trans_2; pfam07885 768494001966 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 768494001967 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 768494001968 catalytic triad [active] 768494001969 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768494001970 metal binding site 2 [ion binding]; metal-binding site 768494001971 putative DNA binding helix; other site 768494001972 metal binding site 1 [ion binding]; metal-binding site 768494001973 dimer interface [polypeptide binding]; other site 768494001974 structural Zn2+ binding site [ion binding]; other site 768494001975 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 768494001976 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 768494001977 hypothetical protein; Provisional; Region: PRK12378 768494001978 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 768494001979 nudix motif; other site 768494001980 Transglycosylase; Region: Transgly; pfam00912 768494001981 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 768494001982 Thioredoxin; Region: Thioredoxin_4; pfam13462 768494001983 epoxyqueuosine reductase; Region: TIGR00276 768494001984 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 768494001985 Putative amidase domain; Region: Amidase_6; pfam12671 768494001986 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 768494001987 PAS fold; Region: PAS_4; pfam08448 768494001988 PAS domain S-box; Region: sensory_box; TIGR00229 768494001989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494001990 putative active site [active] 768494001991 heme pocket [chemical binding]; other site 768494001992 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768494001993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768494001994 metal binding site [ion binding]; metal-binding site 768494001995 active site 768494001996 I-site; other site 768494001997 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768494001998 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 768494001999 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 768494002000 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 768494002001 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 768494002002 heme-binding site [chemical binding]; other site 768494002003 Leucine rich repeat; Region: LRR_8; pfam13855 768494002004 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 768494002005 Substrate binding site [chemical binding]; other site 768494002006 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 768494002007 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 768494002008 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 768494002009 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 768494002010 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 768494002011 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 768494002012 Leucine rich repeat; Region: LRR_8; pfam13855 768494002013 Leucine rich repeat; Region: LRR_8; pfam13855 768494002014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494002015 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768494002016 Coenzyme A binding pocket [chemical binding]; other site 768494002017 BCCT family transporter; Region: BCCT; pfam02028 768494002018 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 768494002019 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 768494002020 FOG: PKD repeat [General function prediction only]; Region: COG3291 768494002021 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 768494002022 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 768494002023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 768494002024 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 768494002025 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 768494002026 Cache domain; Region: Cache_1; pfam02743 768494002027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494002028 dimerization interface [polypeptide binding]; other site 768494002029 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768494002030 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494002031 dimer interface [polypeptide binding]; other site 768494002032 putative CheW interface [polypeptide binding]; other site 768494002033 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 768494002034 PAS domain; Region: PAS; smart00091 768494002035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494002036 ATP binding site [chemical binding]; other site 768494002037 Mg2+ binding site [ion binding]; other site 768494002038 G-X-G motif; other site 768494002039 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 768494002040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494002041 active site 768494002042 phosphorylation site [posttranslational modification] 768494002043 intermolecular recognition site; other site 768494002044 dimerization interface [polypeptide binding]; other site 768494002045 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 768494002046 Citrate transporter; Region: CitMHS; pfam03600 768494002047 hypothetical protein; Provisional; Region: PRK12784 768494002048 NosL; Region: NosL; cl01769 768494002049 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768494002050 Ankyrin repeat; Region: Ank; pfam00023 768494002051 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768494002052 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 768494002053 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768494002054 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 768494002055 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768494002056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494002057 Walker A/P-loop; other site 768494002058 ATP binding site [chemical binding]; other site 768494002059 Q-loop/lid; other site 768494002060 ABC transporter signature motif; other site 768494002061 Walker B; other site 768494002062 D-loop; other site 768494002063 H-loop/switch region; other site 768494002064 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 768494002065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494002066 dimer interface [polypeptide binding]; other site 768494002067 conserved gate region; other site 768494002068 putative PBP binding loops; other site 768494002069 ABC-ATPase subunit interface; other site 768494002070 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768494002071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494002072 conserved gate region; other site 768494002073 dimer interface [polypeptide binding]; other site 768494002074 putative PBP binding loops; other site 768494002075 ABC-ATPase subunit interface; other site 768494002076 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768494002077 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768494002078 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768494002079 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 768494002080 active site 768494002081 metal binding site [ion binding]; metal-binding site 768494002082 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494002083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494002084 active site 768494002085 phosphorylation site [posttranslational modification] 768494002086 intermolecular recognition site; other site 768494002087 dimerization interface [polypeptide binding]; other site 768494002088 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494002089 DNA binding site [nucleotide binding] 768494002090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494002091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494002092 dimer interface [polypeptide binding]; other site 768494002093 phosphorylation site [posttranslational modification] 768494002094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494002095 ATP binding site [chemical binding]; other site 768494002096 Mg2+ binding site [ion binding]; other site 768494002097 G-X-G motif; other site 768494002098 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 768494002099 putative active site [active] 768494002100 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 768494002101 Cache domain; Region: Cache_1; pfam02743 768494002102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494002103 dimerization interface [polypeptide binding]; other site 768494002104 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768494002105 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494002106 dimer interface [polypeptide binding]; other site 768494002107 putative CheW interface [polypeptide binding]; other site 768494002108 sensory histidine kinase DcuS; Provisional; Region: PRK11086 768494002109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494002110 ATP binding site [chemical binding]; other site 768494002111 Mg2+ binding site [ion binding]; other site 768494002112 G-X-G motif; other site 768494002113 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 768494002114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494002115 active site 768494002116 phosphorylation site [posttranslational modification] 768494002117 intermolecular recognition site; other site 768494002118 dimerization interface [polypeptide binding]; other site 768494002119 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 768494002120 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 768494002121 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768494002122 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 768494002123 putative NAD(P) binding site [chemical binding]; other site 768494002124 EamA-like transporter family; Region: EamA; pfam00892 768494002125 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768494002126 EamA-like transporter family; Region: EamA; pfam00892 768494002127 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768494002128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494002129 DNA-binding site [nucleotide binding]; DNA binding site 768494002130 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494002131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494002132 homodimer interface [polypeptide binding]; other site 768494002133 catalytic residue [active] 768494002134 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 768494002135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494002136 Coenzyme A binding pocket [chemical binding]; other site 768494002137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494002138 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494002139 dimerization interface [polypeptide binding]; other site 768494002140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494002141 dimer interface [polypeptide binding]; other site 768494002142 phosphorylation site [posttranslational modification] 768494002143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494002144 ATP binding site [chemical binding]; other site 768494002145 Mg2+ binding site [ion binding]; other site 768494002146 G-X-G motif; other site 768494002147 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494002148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494002149 active site 768494002150 phosphorylation site [posttranslational modification] 768494002151 intermolecular recognition site; other site 768494002152 dimerization interface [polypeptide binding]; other site 768494002153 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494002154 DNA binding site [nucleotide binding] 768494002155 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 768494002156 Arrestin_N terminal like; Region: LDB19; pfam13002 768494002157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494002158 Coenzyme A binding pocket [chemical binding]; other site 768494002159 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 768494002160 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 768494002161 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768494002162 catalytic loop [active] 768494002163 iron binding site [ion binding]; other site 768494002164 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 768494002165 4Fe-4S binding domain; Region: Fer4; pfam00037 768494002166 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 768494002167 [4Fe-4S] binding site [ion binding]; other site 768494002168 molybdopterin cofactor binding site; other site 768494002169 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 768494002170 molybdopterin cofactor binding site; other site 768494002171 Uncharacterized conserved protein [Function unknown]; Region: COG2427 768494002172 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 768494002173 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768494002174 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 768494002175 putative active site [active] 768494002176 catalytic site [active] 768494002177 putative metal binding site [ion binding]; other site 768494002178 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 768494002179 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 768494002180 hexamer interface [polypeptide binding]; other site 768494002181 ligand binding site [chemical binding]; other site 768494002182 putative active site [active] 768494002183 NAD(P) binding site [chemical binding]; other site 768494002184 amino acid transporter; Region: 2A0306; TIGR00909 768494002185 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 768494002186 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494002187 dimerization interface [polypeptide binding]; other site 768494002188 putative DNA binding site [nucleotide binding]; other site 768494002189 putative Zn2+ binding site [ion binding]; other site 768494002190 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768494002191 metal-binding site [ion binding] 768494002192 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 768494002193 Heavy-metal-associated domain; Region: HMA; pfam00403 768494002194 metal-binding site [ion binding] 768494002195 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768494002196 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768494002197 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 768494002198 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 768494002199 active site 768494002200 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494002201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494002202 non-specific DNA binding site [nucleotide binding]; other site 768494002203 salt bridge; other site 768494002204 sequence-specific DNA binding site [nucleotide binding]; other site 768494002205 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768494002206 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 768494002207 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 768494002208 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 768494002209 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 768494002210 active site 768494002211 Zn binding site [ion binding]; other site 768494002212 Uncharacterized conserved protein [Function unknown]; Region: COG0398 768494002213 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768494002214 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 768494002215 VanW like protein; Region: VanW; pfam04294 768494002216 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 768494002217 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768494002218 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768494002219 Nucleoside recognition; Region: Gate; pfam07670 768494002220 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768494002221 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 768494002222 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494002223 Domain of unknown function DUF21; Region: DUF21; pfam01595 768494002224 FOG: CBS domain [General function prediction only]; Region: COG0517 768494002225 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768494002226 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 768494002227 Aspartase; Region: Aspartase; cd01357 768494002228 active sites [active] 768494002229 tetramer interface [polypeptide binding]; other site 768494002230 L-lactate permease; Region: Lactate_perm; cl00701 768494002231 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 768494002232 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494002233 dimerization interface [polypeptide binding]; other site 768494002234 putative Zn2+ binding site [ion binding]; other site 768494002235 putative DNA binding site [nucleotide binding]; other site 768494002236 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 768494002237 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 768494002238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494002239 putative substrate translocation pore; other site 768494002240 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768494002241 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768494002242 siderophore binding site; other site 768494002243 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768494002244 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494002245 ABC-ATPase subunit interface; other site 768494002246 dimer interface [polypeptide binding]; other site 768494002247 putative PBP binding regions; other site 768494002248 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768494002249 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494002250 ABC-ATPase subunit interface; other site 768494002251 dimer interface [polypeptide binding]; other site 768494002252 putative PBP binding regions; other site 768494002253 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768494002254 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768494002255 Walker A/P-loop; other site 768494002256 ATP binding site [chemical binding]; other site 768494002257 Q-loop/lid; other site 768494002258 ABC transporter signature motif; other site 768494002259 Walker B; other site 768494002260 D-loop; other site 768494002261 H-loop/switch region; other site 768494002262 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768494002263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494002264 S-adenosylmethionine binding site [chemical binding]; other site 768494002265 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768494002266 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 768494002267 substrate-cofactor binding pocket; other site 768494002268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494002269 catalytic residue [active] 768494002270 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768494002271 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 768494002272 NAD binding site [chemical binding]; other site 768494002273 homodimer interface [polypeptide binding]; other site 768494002274 active site 768494002275 putative substrate binding site [chemical binding]; other site 768494002276 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 768494002277 nudix motif; other site 768494002278 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 768494002279 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 768494002280 metal ion-dependent adhesion site (MIDAS); other site 768494002281 MoxR-like ATPases [General function prediction only]; Region: COG0714 768494002282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494002283 Walker A motif; other site 768494002284 ATP binding site [chemical binding]; other site 768494002285 Walker B motif; other site 768494002286 arginine finger; other site 768494002287 cardiolipin synthetase; Reviewed; Region: PRK12452 768494002288 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 768494002289 putative active site [active] 768494002290 catalytic site [active] 768494002291 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 768494002292 putative active site [active] 768494002293 catalytic site [active] 768494002294 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494002295 PAS domain; Region: PAS_9; pfam13426 768494002296 putative active site [active] 768494002297 heme pocket [chemical binding]; other site 768494002298 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768494002299 metal binding site [ion binding]; metal-binding site 768494002300 active site 768494002301 I-site; other site 768494002302 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768494002303 Amino acid permease; Region: AA_permease_2; pfam13520 768494002304 Spore germination protein; Region: Spore_permease; cl17796 768494002305 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494002306 DNA-binding site [nucleotide binding]; DNA binding site 768494002307 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 768494002308 UTRA domain; Region: UTRA; pfam07702 768494002309 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 768494002310 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768494002311 active site turn [active] 768494002312 phosphorylation site [posttranslational modification] 768494002313 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768494002314 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768494002315 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768494002316 Ca binding site [ion binding]; other site 768494002317 active site 768494002318 catalytic site [active] 768494002319 potential frameshift: common BLAST hit: gi|227816497|ref|YP_002816506.1| spore germination protein GerKC 768494002320 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 768494002321 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 768494002322 Spore germination protein; Region: Spore_permease; cl17796 768494002323 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 768494002324 CAAX protease self-immunity; Region: Abi; pfam02517 768494002325 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 768494002326 active site 768494002327 ATP binding site [chemical binding]; other site 768494002328 substrate binding site [chemical binding]; other site 768494002329 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768494002330 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 768494002331 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768494002332 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768494002333 Walker A/P-loop; other site 768494002334 ATP binding site [chemical binding]; other site 768494002335 Q-loop/lid; other site 768494002336 ABC transporter signature motif; other site 768494002337 Walker B; other site 768494002338 D-loop; other site 768494002339 H-loop/switch region; other site 768494002340 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768494002341 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768494002342 substrate binding pocket [chemical binding]; other site 768494002343 membrane-bound complex binding site; other site 768494002344 hinge residues; other site 768494002345 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768494002346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494002347 dimer interface [polypeptide binding]; other site 768494002348 conserved gate region; other site 768494002349 putative PBP binding loops; other site 768494002350 ABC-ATPase subunit interface; other site 768494002351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494002352 dimer interface [polypeptide binding]; other site 768494002353 conserved gate region; other site 768494002354 putative PBP binding loops; other site 768494002355 ABC-ATPase subunit interface; other site 768494002356 S-methylmethionine transporter; Provisional; Region: PRK11387 768494002357 OsmC-like protein; Region: OsmC; pfam02566 768494002358 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 768494002359 nucleotide binding site/active site [active] 768494002360 HIT family signature motif; other site 768494002361 catalytic residue [active] 768494002362 RNA polymerase sigma factor; Provisional; Region: PRK12542 768494002363 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494002364 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494002365 DNA binding residues [nucleotide binding] 768494002366 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 768494002367 Predicted transcriptional regulator [Transcription]; Region: COG2378 768494002368 HTH domain; Region: HTH_11; pfam08279 768494002369 WYL domain; Region: WYL; pfam13280 768494002370 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 768494002371 RibD C-terminal domain; Region: RibD_C; cl17279 768494002372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494002373 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494002374 dimerization interface [polypeptide binding]; other site 768494002375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494002376 dimer interface [polypeptide binding]; other site 768494002377 phosphorylation site [posttranslational modification] 768494002378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494002379 ATP binding site [chemical binding]; other site 768494002380 Mg2+ binding site [ion binding]; other site 768494002381 G-X-G motif; other site 768494002382 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494002383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494002384 active site 768494002385 phosphorylation site [posttranslational modification] 768494002386 intermolecular recognition site; other site 768494002387 dimerization interface [polypeptide binding]; other site 768494002388 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494002389 DNA binding site [nucleotide binding] 768494002390 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 768494002391 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768494002392 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768494002393 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768494002394 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768494002395 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768494002396 Ligand Binding Site [chemical binding]; other site 768494002397 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 768494002398 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 768494002399 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768494002400 peptide binding site [polypeptide binding]; other site 768494002401 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 768494002402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494002403 dimer interface [polypeptide binding]; other site 768494002404 conserved gate region; other site 768494002405 putative PBP binding loops; other site 768494002406 ABC-ATPase subunit interface; other site 768494002407 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768494002408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494002409 putative PBP binding loops; other site 768494002410 ABC-ATPase subunit interface; other site 768494002411 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 768494002412 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768494002413 Walker A/P-loop; other site 768494002414 ATP binding site [chemical binding]; other site 768494002415 Q-loop/lid; other site 768494002416 ABC transporter signature motif; other site 768494002417 Walker B; other site 768494002418 D-loop; other site 768494002419 H-loop/switch region; other site 768494002420 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 768494002421 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768494002422 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768494002423 Walker A/P-loop; other site 768494002424 ATP binding site [chemical binding]; other site 768494002425 Q-loop/lid; other site 768494002426 ABC transporter signature motif; other site 768494002427 Walker B; other site 768494002428 D-loop; other site 768494002429 H-loop/switch region; other site 768494002430 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768494002431 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 768494002432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494002433 putative substrate translocation pore; other site 768494002434 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494002435 MarR family; Region: MarR; pfam01047 768494002436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494002437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494002438 putative substrate translocation pore; other site 768494002439 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768494002440 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768494002441 DNA binding site [nucleotide binding] 768494002442 domain linker motif; other site 768494002443 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 768494002444 dimerization interface [polypeptide binding]; other site 768494002445 ligand binding site [chemical binding]; other site 768494002446 sodium binding site [ion binding]; other site 768494002447 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768494002448 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 768494002449 substrate binding site [chemical binding]; other site 768494002450 dimer interface [polypeptide binding]; other site 768494002451 ATP binding site [chemical binding]; other site 768494002452 D-ribose pyranase; Provisional; Region: PRK11797 768494002453 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768494002454 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768494002455 Walker A/P-loop; other site 768494002456 ATP binding site [chemical binding]; other site 768494002457 Q-loop/lid; other site 768494002458 ABC transporter signature motif; other site 768494002459 Walker B; other site 768494002460 D-loop; other site 768494002461 H-loop/switch region; other site 768494002462 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768494002463 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768494002464 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768494002465 TM-ABC transporter signature motif; other site 768494002466 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 768494002467 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 768494002468 ligand binding site [chemical binding]; other site 768494002469 dimerization interface [polypeptide binding]; other site 768494002470 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 768494002471 active site 768494002472 intersubunit interactions; other site 768494002473 catalytic residue [active] 768494002474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 768494002475 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 768494002476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494002477 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494002478 putative substrate translocation pore; other site 768494002479 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768494002480 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 768494002481 putative NAD(P) binding site [chemical binding]; other site 768494002482 catalytic Zn binding site [ion binding]; other site 768494002483 Ion channel; Region: Ion_trans_2; pfam07885 768494002484 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 768494002485 Zn binding site [ion binding]; other site 768494002486 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 768494002487 putative catalytic site [active] 768494002488 metal binding site A [ion binding]; metal-binding site 768494002489 phosphate binding site [ion binding]; other site 768494002490 metal binding site C [ion binding]; metal-binding site 768494002491 metal binding site B [ion binding]; metal-binding site 768494002492 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 768494002493 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 768494002494 dimer interface [polypeptide binding]; other site 768494002495 active site 768494002496 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768494002497 substrate binding site [chemical binding]; other site 768494002498 catalytic residue [active] 768494002499 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 768494002500 FAD binding domain; Region: FAD_binding_4; pfam01565 768494002501 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 768494002502 VanZ like family; Region: VanZ; pfam04892 768494002503 RDD family; Region: RDD; pfam06271 768494002504 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 768494002505 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768494002506 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494002507 dimer interface [polypeptide binding]; other site 768494002508 putative CheW interface [polypeptide binding]; other site 768494002509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 768494002510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 768494002511 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494002512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494002513 non-specific DNA binding site [nucleotide binding]; other site 768494002514 salt bridge; other site 768494002515 sequence-specific DNA binding site [nucleotide binding]; other site 768494002516 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 768494002517 active site 768494002518 catalytic site [active] 768494002519 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 768494002520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494002521 putative substrate translocation pore; other site 768494002522 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 768494002523 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 768494002524 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 768494002525 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 768494002526 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 768494002527 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768494002528 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494002529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494002530 non-specific DNA binding site [nucleotide binding]; other site 768494002531 salt bridge; other site 768494002532 sequence-specific DNA binding site [nucleotide binding]; other site 768494002533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494002534 Coenzyme A binding pocket [chemical binding]; other site 768494002535 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 768494002536 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 768494002537 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768494002538 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 768494002539 TrkA-N domain; Region: TrkA_N; pfam02254 768494002540 TrkA-C domain; Region: TrkA_C; pfam02080 768494002541 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 768494002542 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 768494002543 Subunit I/III interface [polypeptide binding]; other site 768494002544 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 768494002545 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 768494002546 D-pathway; other site 768494002547 Putative ubiquinol binding site [chemical binding]; other site 768494002548 Low-spin heme (heme b) binding site [chemical binding]; other site 768494002549 Putative water exit pathway; other site 768494002550 Binuclear center (heme o3/CuB) [ion binding]; other site 768494002551 K-pathway; other site 768494002552 Putative proton exit pathway; other site 768494002553 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 768494002554 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 768494002555 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 768494002556 putative active site [active] 768494002557 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768494002558 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 768494002559 metal binding site [ion binding]; metal-binding site 768494002560 dimer interface [polypeptide binding]; other site 768494002561 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 768494002562 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 768494002563 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768494002564 Na binding site [ion binding]; other site 768494002565 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 768494002566 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 768494002567 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 768494002568 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 768494002569 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 768494002570 Nucleoside recognition; Region: Gate; pfam07670 768494002571 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 768494002572 Nucleoside recognition; Region: Gate; pfam07670 768494002573 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 768494002574 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 768494002575 G1 box; other site 768494002576 GTP/Mg2+ binding site [chemical binding]; other site 768494002577 Switch I region; other site 768494002578 G2 box; other site 768494002579 G3 box; other site 768494002580 Switch II region; other site 768494002581 G4 box; other site 768494002582 G5 box; other site 768494002583 FeoA domain; Region: FeoA; pfam04023 768494002584 phosphate binding protein; Region: ptsS_2; TIGR02136 768494002585 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768494002586 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 768494002587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494002588 dimer interface [polypeptide binding]; other site 768494002589 conserved gate region; other site 768494002590 putative PBP binding loops; other site 768494002591 ABC-ATPase subunit interface; other site 768494002592 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 768494002593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494002594 dimer interface [polypeptide binding]; other site 768494002595 conserved gate region; other site 768494002596 putative PBP binding loops; other site 768494002597 ABC-ATPase subunit interface; other site 768494002598 AAA domain; Region: AAA_33; pfam13671 768494002599 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 768494002600 active site 768494002601 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768494002602 FOG: CBS domain [General function prediction only]; Region: COG0517 768494002603 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 768494002604 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 768494002605 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 768494002606 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494002607 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494002608 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494002609 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 768494002610 Peptidase family M23; Region: Peptidase_M23; pfam01551 768494002611 Putative transcription activator [Transcription]; Region: TenA; COG0819 768494002612 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768494002613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494002614 Q-loop/lid; other site 768494002615 ABC transporter signature motif; other site 768494002616 Walker B; other site 768494002617 D-loop; other site 768494002618 H-loop/switch region; other site 768494002619 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768494002620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494002621 dimer interface [polypeptide binding]; other site 768494002622 conserved gate region; other site 768494002623 putative PBP binding loops; other site 768494002624 ABC-ATPase subunit interface; other site 768494002625 NMT1/THI5 like; Region: NMT1; pfam09084 768494002626 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 768494002627 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 768494002628 thiamine phosphate binding site [chemical binding]; other site 768494002629 active site 768494002630 pyrophosphate binding site [ion binding]; other site 768494002631 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 768494002632 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768494002633 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 768494002634 thiS-thiF/thiG interaction site; other site 768494002635 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 768494002636 ThiS interaction site; other site 768494002637 putative active site [active] 768494002638 tetramer interface [polypeptide binding]; other site 768494002639 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 768494002640 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768494002641 ATP binding site [chemical binding]; other site 768494002642 substrate interface [chemical binding]; other site 768494002643 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 768494002644 dimer interface [polypeptide binding]; other site 768494002645 substrate binding site [chemical binding]; other site 768494002646 ATP binding site [chemical binding]; other site 768494002647 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 768494002648 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 768494002649 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768494002650 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768494002651 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 768494002652 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 768494002653 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 768494002654 Ligand Binding Site [chemical binding]; other site 768494002655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494002656 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494002657 putative substrate translocation pore; other site 768494002658 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494002659 MarR family; Region: MarR; pfam01047 768494002660 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 768494002661 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 768494002662 active site 768494002663 nucleophile elbow; other site 768494002664 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768494002665 short chain dehydrogenase; Provisional; Region: PRK06701 768494002666 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 768494002667 NAD binding site [chemical binding]; other site 768494002668 metal binding site [ion binding]; metal-binding site 768494002669 active site 768494002670 potential frameshift: common BLAST hit: gi|49480296|ref|YP_035009.1| ErfK/YbiS/YcfS/YnhG family protein 768494002671 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768494002672 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768494002673 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 768494002674 putative substrate binding site [chemical binding]; other site 768494002675 putative ATP binding site [chemical binding]; other site 768494002676 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 768494002677 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 768494002678 substrate binding [chemical binding]; other site 768494002679 active site 768494002680 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 768494002681 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 768494002682 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768494002683 active site turn [active] 768494002684 phosphorylation site [posttranslational modification] 768494002685 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768494002686 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768494002687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768494002688 DNA binding site [nucleotide binding] 768494002689 domain linker motif; other site 768494002690 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 768494002691 dimerization interface [polypeptide binding]; other site 768494002692 ligand binding site [chemical binding]; other site 768494002693 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 768494002694 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768494002695 catalytic residues [active] 768494002696 putative disulfide oxidoreductase; Provisional; Region: PRK03113 768494002697 YhdB-like protein; Region: YhdB; pfam14148 768494002698 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 768494002699 Spore germination protein; Region: Spore_permease; cl17796 768494002700 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 768494002701 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 768494002702 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 768494002703 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 768494002704 putative FMN binding site [chemical binding]; other site 768494002705 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 768494002706 SpoVR like protein; Region: SpoVR; pfam04293 768494002707 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 768494002708 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 768494002709 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494002710 putative DNA binding site [nucleotide binding]; other site 768494002711 putative Zn2+ binding site [ion binding]; other site 768494002712 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494002713 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 768494002714 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 768494002715 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 768494002716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494002717 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768494002718 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 768494002719 active site residue [active] 768494002720 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 768494002721 putative homodimer interface [polypeptide binding]; other site 768494002722 putative homotetramer interface [polypeptide binding]; other site 768494002723 putative metal binding site [ion binding]; other site 768494002724 putative homodimer-homodimer interface [polypeptide binding]; other site 768494002725 putative allosteric switch controlling residues; other site 768494002726 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 768494002727 CPxP motif; other site 768494002728 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768494002729 active site residue [active] 768494002730 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 768494002731 active site residue [active] 768494002732 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494002733 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 768494002734 CPxP motif; other site 768494002735 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768494002736 active site residue [active] 768494002737 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768494002738 active site residue [active] 768494002739 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 768494002740 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768494002741 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 768494002742 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 768494002743 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 768494002744 NADP binding site [chemical binding]; other site 768494002745 dimer interface [polypeptide binding]; other site 768494002746 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 768494002747 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 768494002748 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 768494002749 PhoU domain; Region: PhoU; pfam01895 768494002750 PhoU domain; Region: PhoU; pfam01895 768494002751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494002752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494002753 putative substrate translocation pore; other site 768494002754 Uncharacterized conserved protein [Function unknown]; Region: COG3589 768494002755 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 768494002756 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 768494002757 HTH domain; Region: HTH_11; pfam08279 768494002758 Mga helix-turn-helix domain; Region: Mga; pfam05043 768494002759 PRD domain; Region: PRD; pfam00874 768494002760 PRD domain; Region: PRD; pfam00874 768494002761 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 768494002762 active site 768494002763 P-loop; other site 768494002764 phosphorylation site [posttranslational modification] 768494002765 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768494002766 active site 768494002767 phosphorylation site [posttranslational modification] 768494002768 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768494002769 active site 768494002770 methionine cluster; other site 768494002771 phosphorylation site [posttranslational modification] 768494002772 metal binding site [ion binding]; metal-binding site 768494002773 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768494002774 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768494002775 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768494002776 Uncharacterized conserved protein [Function unknown]; Region: COG3589 768494002777 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 768494002778 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494002779 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494002780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 768494002781 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768494002782 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768494002783 FtsX-like permease family; Region: FtsX; pfam02687 768494002784 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768494002785 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768494002786 Walker A/P-loop; other site 768494002787 ATP binding site [chemical binding]; other site 768494002788 Q-loop/lid; other site 768494002789 ABC transporter signature motif; other site 768494002790 Walker B; other site 768494002791 D-loop; other site 768494002792 H-loop/switch region; other site 768494002793 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768494002794 HlyD family secretion protein; Region: HlyD_3; pfam13437 768494002795 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 768494002796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768494002797 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768494002798 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768494002799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494002800 dimer interface [polypeptide binding]; other site 768494002801 conserved gate region; other site 768494002802 ABC-ATPase subunit interface; other site 768494002803 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 768494002804 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 768494002805 dimanganese center [ion binding]; other site 768494002806 CotJB protein; Region: CotJB; pfam12652 768494002807 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 768494002808 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494002809 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768494002810 active site 768494002811 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 768494002812 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 768494002813 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 768494002814 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 768494002815 putative DNA binding site [nucleotide binding]; other site 768494002816 putative homodimer interface [polypeptide binding]; other site 768494002817 Uncharacterized conserved protein [Function unknown]; Region: COG3339 768494002818 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768494002819 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768494002820 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 768494002821 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 768494002822 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768494002823 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 768494002824 active site 768494002825 metal binding site [ion binding]; metal-binding site 768494002826 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768494002827 Interdomain contacts; other site 768494002828 Cytokine receptor motif; other site 768494002829 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 768494002830 amino acid transporter; Region: 2A0306; TIGR00909 768494002831 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 768494002832 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 768494002833 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768494002834 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768494002835 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768494002836 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768494002837 putative active site [active] 768494002838 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 768494002839 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 768494002840 putative active site [active] 768494002841 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768494002842 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 768494002843 active site turn [active] 768494002844 phosphorylation site [posttranslational modification] 768494002845 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768494002846 Uncharacterized conserved protein [Function unknown]; Region: COG3589 768494002847 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 768494002848 DoxX; Region: DoxX; pfam07681 768494002849 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 768494002850 hypothetical protein; Provisional; Region: PRK06770 768494002851 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768494002852 EamA-like transporter family; Region: EamA; pfam00892 768494002853 EamA-like transporter family; Region: EamA; pfam00892 768494002854 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768494002855 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 768494002856 AsnC family; Region: AsnC_trans_reg; pfam01037 768494002857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494002858 Coenzyme A binding pocket [chemical binding]; other site 768494002859 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 768494002860 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 768494002861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494002862 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494002863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494002864 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494002865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494002866 Predicted transcriptional regulators [Transcription]; Region: COG1733 768494002867 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494002868 putative DNA binding site [nucleotide binding]; other site 768494002869 putative Zn2+ binding site [ion binding]; other site 768494002870 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 768494002871 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768494002872 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 768494002873 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 768494002874 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 768494002875 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 768494002876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494002877 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494002878 putative substrate translocation pore; other site 768494002879 intracellular protease, PfpI family; Region: PfpI; TIGR01382 768494002880 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 768494002881 proposed catalytic triad [active] 768494002882 conserved cys residue [active] 768494002883 hydroperoxidase II; Provisional; Region: katE; PRK11249 768494002884 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 768494002885 tetramer interface [polypeptide binding]; other site 768494002886 heme binding pocket [chemical binding]; other site 768494002887 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 768494002888 domain interactions; other site 768494002889 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 768494002890 arginine:agmatin antiporter; Provisional; Region: PRK10644 768494002891 Spore germination protein; Region: Spore_permease; cl17796 768494002892 glutamate racemase; Provisional; Region: PRK00865 768494002893 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 768494002894 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 768494002895 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 768494002896 tetrameric interface [polypeptide binding]; other site 768494002897 activator binding site; other site 768494002898 NADP binding site [chemical binding]; other site 768494002899 substrate binding site [chemical binding]; other site 768494002900 catalytic residues [active] 768494002901 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494002902 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 768494002903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494002904 Walker A/P-loop; other site 768494002905 ATP binding site [chemical binding]; other site 768494002906 Q-loop/lid; other site 768494002907 ABC transporter signature motif; other site 768494002908 Walker B; other site 768494002909 D-loop; other site 768494002910 H-loop/switch region; other site 768494002911 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768494002912 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494002913 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 768494002914 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 768494002915 Walker A/P-loop; other site 768494002916 ATP binding site [chemical binding]; other site 768494002917 Q-loop/lid; other site 768494002918 ABC transporter signature motif; other site 768494002919 Walker B; other site 768494002920 D-loop; other site 768494002921 H-loop/switch region; other site 768494002922 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768494002923 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768494002924 substrate binding pocket [chemical binding]; other site 768494002925 membrane-bound complex binding site; other site 768494002926 hinge residues; other site 768494002927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494002928 dimer interface [polypeptide binding]; other site 768494002929 conserved gate region; other site 768494002930 putative PBP binding loops; other site 768494002931 ABC-ATPase subunit interface; other site 768494002932 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768494002933 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768494002934 Walker A/P-loop; other site 768494002935 ATP binding site [chemical binding]; other site 768494002936 Q-loop/lid; other site 768494002937 ABC transporter signature motif; other site 768494002938 Walker B; other site 768494002939 D-loop; other site 768494002940 H-loop/switch region; other site 768494002941 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 768494002942 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 768494002943 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 768494002944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 768494002945 hypothetical protein; Provisional; Region: PRK13676 768494002946 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 768494002947 acetolactate synthase; Reviewed; Region: PRK08617 768494002948 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768494002949 PYR/PP interface [polypeptide binding]; other site 768494002950 dimer interface [polypeptide binding]; other site 768494002951 TPP binding site [chemical binding]; other site 768494002952 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768494002953 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 768494002954 TPP-binding site [chemical binding]; other site 768494002955 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 768494002956 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 768494002957 active site 768494002958 DNA binding site [nucleotide binding] 768494002959 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 768494002960 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768494002961 active site 768494002962 motif I; other site 768494002963 motif II; other site 768494002964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494002965 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 768494002966 Cna protein B-type domain; Region: Cna_B; pfam05738 768494002967 Cna protein B-type domain; Region: Cna_B; pfam05738 768494002968 Cna protein B-type domain; Region: Cna_B; pfam05738 768494002969 Cna protein B-type domain; Region: Cna_B; pfam05738 768494002970 Cna protein B-type domain; Region: Cna_B; pfam05738 768494002971 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768494002972 amidase catalytic site [active] 768494002973 Zn binding residues [ion binding]; other site 768494002974 substrate binding site [chemical binding]; other site 768494002975 S-layer homology domain; Region: SLH; pfam00395 768494002976 S-layer homology domain; Region: SLH; pfam00395 768494002977 S-layer homology domain; Region: SLH; pfam00395 768494002978 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 768494002979 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 768494002980 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768494002981 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 768494002982 acyl-activating enzyme (AAE) consensus motif; other site 768494002983 acyl-activating enzyme (AAE) consensus motif; other site 768494002984 putative AMP binding site [chemical binding]; other site 768494002985 putative active site [active] 768494002986 putative CoA binding site [chemical binding]; other site 768494002987 high affinity sulphate transporter 1; Region: sulP; TIGR00815 768494002988 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768494002989 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768494002990 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 768494002991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 768494002992 ATP binding site [chemical binding]; other site 768494002993 putative Mg++ binding site [ion binding]; other site 768494002994 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 768494002995 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494002996 nucleotide binding region [chemical binding]; other site 768494002997 ATP-binding site [chemical binding]; other site 768494002998 stage V sporulation protein B; Region: spore_V_B; TIGR02900 768494002999 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 768494003000 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 768494003001 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 768494003002 S-layer homology domain; Region: SLH; pfam00395 768494003003 S-layer homology domain; Region: SLH; pfam00395 768494003004 S-layer homology domain; Region: SLH; pfam00395 768494003005 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 768494003006 S-layer homology domain; Region: SLH; pfam00395 768494003007 S-layer homology domain; Region: SLH; pfam00395 768494003008 S-layer homology domain; Region: SLH; pfam00395 768494003009 DHHW protein; Region: DHHW; pfam14286 768494003010 DHHW protein; Region: DHHW; pfam14286 768494003011 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 768494003012 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 768494003013 enoyl-CoA hydratase; Provisional; Region: PRK07659 768494003014 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768494003015 substrate binding site [chemical binding]; other site 768494003016 oxyanion hole (OAH) forming residues; other site 768494003017 trimer interface [polypeptide binding]; other site 768494003018 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 768494003019 metal binding site [ion binding]; metal-binding site 768494003020 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 768494003021 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 768494003022 putative oligomer interface [polypeptide binding]; other site 768494003023 putative active site [active] 768494003024 metal binding site [ion binding]; metal-binding site 768494003025 S-layer homology domain; Region: SLH; pfam00395 768494003026 S-layer homology domain; Region: SLH; pfam00395 768494003027 S-layer homology domain; Region: SLH; pfam00395 768494003028 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 768494003029 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768494003030 active site 768494003031 metal binding site [ion binding]; metal-binding site 768494003032 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 768494003033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494003034 S-adenosylmethionine binding site [chemical binding]; other site 768494003035 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 768494003036 proline racemase; Provisional; Region: PRK13969 768494003037 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768494003038 ornithine cyclodeaminase; Validated; Region: PRK08618 768494003039 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768494003040 NAD(P) binding site [chemical binding]; other site 768494003041 Yip1 domain; Region: Yip1; pfam04893 768494003042 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 768494003043 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768494003044 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768494003045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494003046 dimer interface [polypeptide binding]; other site 768494003047 conserved gate region; other site 768494003048 putative PBP binding loops; other site 768494003049 ABC-ATPase subunit interface; other site 768494003050 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768494003051 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768494003052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494003053 dimer interface [polypeptide binding]; other site 768494003054 conserved gate region; other site 768494003055 putative PBP binding loops; other site 768494003056 ABC-ATPase subunit interface; other site 768494003057 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768494003058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494003059 Walker A/P-loop; other site 768494003060 ATP binding site [chemical binding]; other site 768494003061 Q-loop/lid; other site 768494003062 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768494003063 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768494003064 ABC transporter signature motif; other site 768494003065 Walker B; other site 768494003066 D-loop; other site 768494003067 H-loop/switch region; other site 768494003068 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768494003069 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 768494003070 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768494003071 Walker A/P-loop; other site 768494003072 ATP binding site [chemical binding]; other site 768494003073 Q-loop/lid; other site 768494003074 ABC transporter signature motif; other site 768494003075 Walker B; other site 768494003076 D-loop; other site 768494003077 H-loop/switch region; other site 768494003078 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768494003079 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 768494003080 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 768494003081 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 768494003082 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 768494003083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494003084 putative substrate translocation pore; other site 768494003085 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 768494003086 PAS domain; Region: PAS; smart00091 768494003087 putative active site [active] 768494003088 heme pocket [chemical binding]; other site 768494003089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494003090 ATP binding site [chemical binding]; other site 768494003091 Mg2+ binding site [ion binding]; other site 768494003092 G-X-G motif; other site 768494003093 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 768494003094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494003095 active site 768494003096 phosphorylation site [posttranslational modification] 768494003097 intermolecular recognition site; other site 768494003098 dimerization interface [polypeptide binding]; other site 768494003099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 768494003100 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 768494003101 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 768494003102 putative metal binding site [ion binding]; other site 768494003103 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 768494003104 putative metal binding site [ion binding]; other site 768494003105 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 768494003106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 768494003107 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 768494003108 Protein of unknown function (DUF524); Region: DUF524; pfam04411 768494003109 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 768494003110 DNA binding residues [nucleotide binding] 768494003111 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 768494003112 dimer interface [polypeptide binding]; other site 768494003113 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768494003114 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 768494003115 replicative DNA helicase; Provisional; Region: PRK06749 768494003116 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768494003117 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768494003118 Walker A motif; other site 768494003119 ATP binding site [chemical binding]; other site 768494003120 Walker B motif; other site 768494003121 DNA binding loops [nucleotide binding] 768494003122 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 768494003123 Predicted transcriptional regulators [Transcription]; Region: COG1378 768494003124 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 768494003125 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 768494003126 C-terminal domain interface [polypeptide binding]; other site 768494003127 sugar binding site [chemical binding]; other site 768494003128 hypothetical protein; Provisional; Region: PRK10621 768494003129 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768494003130 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494003131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494003132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494003133 putative substrate translocation pore; other site 768494003134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494003135 Predicted permease; Region: DUF318; cl17795 768494003136 Predicted permeases [General function prediction only]; Region: COG0701 768494003137 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494003138 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768494003139 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 768494003140 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 768494003141 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 768494003142 CGNR zinc finger; Region: zf-CGNR; pfam11706 768494003143 HPP family; Region: HPP; pfam04982 768494003144 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 768494003145 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768494003146 putative NAD(P) binding site [chemical binding]; other site 768494003147 active site 768494003148 putative substrate binding site [chemical binding]; other site 768494003149 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768494003150 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494003151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494003152 YmzC-like protein; Region: YmzC; pfam14157 768494003153 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 768494003154 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768494003155 MarR family; Region: MarR_2; pfam12802 768494003156 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 768494003157 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 768494003158 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 768494003159 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 768494003160 VanZ like family; Region: VanZ; pfam04892 768494003161 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 768494003162 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 768494003163 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 768494003164 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 768494003165 dihydroxyacetone kinase; Provisional; Region: PRK14479 768494003166 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 768494003167 DAK2 domain; Region: Dak2; pfam02734 768494003168 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 768494003169 Predicted transcriptional regulator [Transcription]; Region: COG1959 768494003170 Transcriptional regulator; Region: Rrf2; pfam02082 768494003171 CAAX protease self-immunity; Region: Abi; pfam02517 768494003172 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 768494003173 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768494003174 Zn2+ binding site [ion binding]; other site 768494003175 Mg2+ binding site [ion binding]; other site 768494003176 S-layer homology domain; Region: SLH; pfam00395 768494003177 S-layer homology domain; Region: SLH; pfam00395 768494003178 S-layer homology domain; Region: SLH; pfam00395 768494003179 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768494003180 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494003181 Transcriptional regulator PadR-like family; Region: PadR; cl17335 768494003182 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 768494003183 Heat induced stress protein YflT; Region: YflT; pfam11181 768494003184 CsbD-like; Region: CsbD; pfam05532 768494003185 Predicted membrane protein [Function unknown]; Region: COG2261 768494003186 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768494003187 anti sigma factor interaction site; other site 768494003188 regulatory phosphorylation site [posttranslational modification]; other site 768494003189 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 768494003190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494003191 ATP binding site [chemical binding]; other site 768494003192 Mg2+ binding site [ion binding]; other site 768494003193 G-X-G motif; other site 768494003194 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494003195 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768494003196 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494003197 DNA binding residues [nucleotide binding] 768494003198 Ferritin-like domain; Region: Ferritin; pfam00210 768494003199 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 768494003200 dinuclear metal binding motif [ion binding]; other site 768494003201 Response regulator receiver domain; Region: Response_reg; pfam00072 768494003202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494003203 active site 768494003204 phosphorylation site [posttranslational modification] 768494003205 intermolecular recognition site; other site 768494003206 dimerization interface [polypeptide binding]; other site 768494003207 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 768494003208 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 768494003209 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 768494003210 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 768494003211 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 768494003212 CHASE3 domain; Region: CHASE3; pfam05227 768494003213 GAF domain; Region: GAF; pfam01590 768494003214 GAF domain; Region: GAF_2; pfam13185 768494003215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494003216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494003217 dimer interface [polypeptide binding]; other site 768494003218 phosphorylation site [posttranslational modification] 768494003219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494003220 ATP binding site [chemical binding]; other site 768494003221 Mg2+ binding site [ion binding]; other site 768494003222 G-X-G motif; other site 768494003223 Response regulator receiver domain; Region: Response_reg; pfam00072 768494003224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494003225 active site 768494003226 phosphorylation site [posttranslational modification] 768494003227 intermolecular recognition site; other site 768494003228 dimerization interface [polypeptide binding]; other site 768494003229 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 768494003230 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 768494003231 hypothetical protein; Provisional; Region: PRK12856 768494003232 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 768494003233 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768494003234 NADP binding site [chemical binding]; other site 768494003235 dimer interface [polypeptide binding]; other site 768494003236 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 768494003237 YhzD-like protein; Region: YhzD; pfam14120 768494003238 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 768494003239 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 768494003240 active site 768494003241 metal binding site [ion binding]; metal-binding site 768494003242 DNA binding site [nucleotide binding] 768494003243 AAA domain; Region: AAA_27; pfam13514 768494003244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 768494003245 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 768494003246 Probable transposase; Region: OrfB_IS605; pfam01385 768494003247 AAA domain; Region: AAA_27; pfam13514 768494003248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494003249 Q-loop/lid; other site 768494003250 ABC transporter signature motif; other site 768494003251 Walker B; other site 768494003252 D-loop; other site 768494003253 H-loop/switch region; other site 768494003254 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 768494003255 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 768494003256 generic binding surface II; other site 768494003257 generic binding surface I; other site 768494003258 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768494003259 Zn2+ binding site [ion binding]; other site 768494003260 Mg2+ binding site [ion binding]; other site 768494003261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494003262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494003263 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768494003264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494003265 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 768494003266 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494003267 Zn binding site [ion binding]; other site 768494003268 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 768494003269 Zn binding site [ion binding]; other site 768494003270 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 768494003271 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494003272 Zn binding site [ion binding]; other site 768494003273 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 768494003274 Zn binding site [ion binding]; other site 768494003275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768494003276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494003277 TPR motif; other site 768494003278 binding surface 768494003279 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768494003280 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 768494003281 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 768494003282 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 768494003283 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 768494003284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494003285 non-specific DNA binding site [nucleotide binding]; other site 768494003286 salt bridge; other site 768494003287 sequence-specific DNA binding site [nucleotide binding]; other site 768494003288 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 768494003289 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 768494003290 amphipathic channel; other site 768494003291 Asn-Pro-Ala signature motifs; other site 768494003292 glycerol kinase; Provisional; Region: glpK; PRK00047 768494003293 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 768494003294 N- and C-terminal domain interface [polypeptide binding]; other site 768494003295 active site 768494003296 MgATP binding site [chemical binding]; other site 768494003297 catalytic site [active] 768494003298 metal binding site [ion binding]; metal-binding site 768494003299 glycerol binding site [chemical binding]; other site 768494003300 homotetramer interface [polypeptide binding]; other site 768494003301 homodimer interface [polypeptide binding]; other site 768494003302 FBP binding site [chemical binding]; other site 768494003303 protein IIAGlc interface [polypeptide binding]; other site 768494003304 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 768494003305 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 768494003306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494003307 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494003308 DNA binding residues [nucleotide binding] 768494003309 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 768494003310 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494003311 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 768494003312 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494003313 MarR family; Region: MarR; pfam01047 768494003314 DoxX-like family; Region: DoxX_2; pfam13564 768494003315 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768494003316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494003317 putative substrate translocation pore; other site 768494003318 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768494003319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494003320 putative substrate translocation pore; other site 768494003321 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 768494003322 Part of AAA domain; Region: AAA_19; pfam13245 768494003323 Family description; Region: UvrD_C_2; pfam13538 768494003324 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 768494003325 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768494003326 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 768494003327 transcriptional regulator Hpr; Provisional; Region: PRK13777 768494003328 MarR family; Region: MarR; pfam01047 768494003329 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 768494003330 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 768494003331 HIT family signature motif; other site 768494003332 catalytic residue [active] 768494003333 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 768494003334 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494003335 Walker A/P-loop; other site 768494003336 ATP binding site [chemical binding]; other site 768494003337 Q-loop/lid; other site 768494003338 ABC transporter signature motif; other site 768494003339 Walker B; other site 768494003340 D-loop; other site 768494003341 H-loop/switch region; other site 768494003342 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 768494003343 EcsC protein family; Region: EcsC; pfam12787 768494003344 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494003345 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494003346 Uncharacterized conserved protein [Function unknown]; Region: COG3402 768494003347 Bacterial PH domain; Region: DUF304; pfam03703 768494003348 Predicted membrane protein [Function unknown]; Region: COG3428 768494003349 Bacterial PH domain; Region: DUF304; cl01348 768494003350 Bacterial PH domain; Region: DUF304; pfam03703 768494003351 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 768494003352 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 768494003353 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 768494003354 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 768494003355 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768494003356 DNA binding residues [nucleotide binding] 768494003357 drug binding residues [chemical binding]; other site 768494003358 dimer interface [polypeptide binding]; other site 768494003359 Uncharacterized conserved protein [Function unknown]; Region: COG3402 768494003360 Predicted membrane protein [Function unknown]; Region: COG3428 768494003361 Bacterial PH domain; Region: DUF304; pfam03703 768494003362 Bacterial PH domain; Region: DUF304; pfam03703 768494003363 Bacterial PH domain; Region: DUF304; pfam03703 768494003364 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 768494003365 Transglycosylase; Region: Transgly; pfam00912 768494003366 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 768494003367 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494003368 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 768494003369 substrate binding site [chemical binding]; other site 768494003370 active site 768494003371 ferrochelatase; Provisional; Region: PRK12435 768494003372 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 768494003373 C-terminal domain interface [polypeptide binding]; other site 768494003374 active site 768494003375 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 768494003376 active site 768494003377 N-terminal domain interface [polypeptide binding]; other site 768494003378 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 768494003379 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768494003380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768494003381 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 768494003382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 768494003383 Fn3 associated; Region: Fn3_assoc; pfam13287 768494003384 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 768494003385 generic binding surface II; other site 768494003386 generic binding surface I; other site 768494003387 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 768494003388 putative active site [active] 768494003389 putative catalytic site [active] 768494003390 putative Mg binding site IVb [ion binding]; other site 768494003391 putative phosphate binding site [ion binding]; other site 768494003392 putative DNA binding site [nucleotide binding]; other site 768494003393 putative Mg binding site IVa [ion binding]; other site 768494003394 Penicillinase repressor; Region: Pencillinase_R; pfam03965 768494003395 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 768494003396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494003397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494003398 Predicted membrane protein [Function unknown]; Region: COG1511 768494003399 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 768494003400 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 768494003401 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 768494003402 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 768494003403 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 768494003404 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494003405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494003406 Coenzyme A binding pocket [chemical binding]; other site 768494003407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768494003408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768494003409 DNA binding site [nucleotide binding] 768494003410 domain linker motif; other site 768494003411 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 768494003412 putative dimerization interface [polypeptide binding]; other site 768494003413 putative ligand binding site [chemical binding]; other site 768494003414 YhfH-like protein; Region: YhfH; pfam14149 768494003415 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 768494003416 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768494003417 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 768494003418 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 768494003419 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 768494003420 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 768494003421 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 768494003422 acyl-activating enzyme (AAE) consensus motif; other site 768494003423 putative AMP binding site [chemical binding]; other site 768494003424 putative active site [active] 768494003425 putative CoA binding site [chemical binding]; other site 768494003426 rod-segment of the talin C-terminal domain; Region: talin-RS; cd12150 768494003427 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 768494003428 heme-binding site [chemical binding]; other site 768494003429 S-layer homology domain; Region: SLH; pfam00395 768494003430 S-layer homology domain; Region: SLH; pfam00395 768494003431 S-layer homology domain; Region: SLH; pfam00395 768494003432 potential frameshift: common BLAST hit: gi|227816056|ref|YP_002816065.1| putative wall-associated protein 768494003433 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 768494003434 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 768494003435 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 768494003436 RHS Repeat; Region: RHS_repeat; cl11982 768494003437 RHS protein; Region: RHS; pfam03527 768494003438 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 768494003439 Aureocin-like type II bacteriocin; Region: Bacteriocin_IIi; pfam11758 768494003440 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 768494003441 RHS protein; Region: RHS; pfam03527 768494003442 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 768494003443 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 768494003444 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 768494003445 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 768494003446 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768494003447 putative active site [active] 768494003448 putative metal binding site [ion binding]; other site 768494003449 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768494003450 Zn2+ binding site [ion binding]; other site 768494003451 Mg2+ binding site [ion binding]; other site 768494003452 Putative zinc-finger; Region: zf-HC2; pfam13490 768494003453 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 768494003454 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 768494003455 RNA polymerase sigma factor; Provisional; Region: PRK12541 768494003456 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494003457 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494003458 DNA binding residues [nucleotide binding] 768494003459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494003460 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768494003461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494003462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 768494003463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494003464 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 768494003465 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494003466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494003467 dimer interface [polypeptide binding]; other site 768494003468 phosphorylation site [posttranslational modification] 768494003469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494003470 ATP binding site [chemical binding]; other site 768494003471 Mg2+ binding site [ion binding]; other site 768494003472 G-X-G motif; other site 768494003473 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494003474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494003475 active site 768494003476 phosphorylation site [posttranslational modification] 768494003477 intermolecular recognition site; other site 768494003478 dimerization interface [polypeptide binding]; other site 768494003479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494003480 DNA binding site [nucleotide binding] 768494003481 CAAX protease self-immunity; Region: Abi; pfam02517 768494003482 Peptidase family M48; Region: Peptidase_M48; pfam01435 768494003483 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 768494003484 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494003485 dimerization interface [polypeptide binding]; other site 768494003486 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768494003487 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494003488 dimer interface [polypeptide binding]; other site 768494003489 putative CheW interface [polypeptide binding]; other site 768494003490 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768494003491 EamA-like transporter family; Region: EamA; pfam00892 768494003492 EamA-like transporter family; Region: EamA; pfam00892 768494003493 S-layer homology domain; Region: SLH; pfam00395 768494003494 S-layer homology domain; Region: SLH; pfam00395 768494003495 S-layer homology domain; Region: SLH; pfam00395 768494003496 S-layer homology domain; Region: SLH; pfam00395 768494003497 S-layer homology domain; Region: SLH; pfam00395 768494003498 S-layer homology domain; Region: SLH; pfam00395 768494003499 S-layer homology domain; Region: SLH; pfam00395 768494003500 S-layer homology domain; Region: SLH; pfam00395 768494003501 S-layer homology domain; Region: SLH; pfam00395 768494003502 malate synthase A; Region: malate_syn_A; TIGR01344 768494003503 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 768494003504 active site 768494003505 isocitrate lyase; Provisional; Region: PRK15063 768494003506 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 768494003507 tetramer interface [polypeptide binding]; other site 768494003508 active site 768494003509 Mg2+/Mn2+ binding site [ion binding]; other site 768494003510 Phosphotransferase enzyme family; Region: APH; pfam01636 768494003511 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 768494003512 active site 768494003513 substrate binding site [chemical binding]; other site 768494003514 ATP binding site [chemical binding]; other site 768494003515 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768494003516 DNA-binding site [nucleotide binding]; DNA binding site 768494003517 RNA-binding motif; other site 768494003518 ComK protein; Region: ComK; pfam06338 768494003519 Uncharacterized conserved protein [Function unknown]; Region: COG0398 768494003520 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768494003521 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 768494003522 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768494003523 Catalytic site [active] 768494003524 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768494003525 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 768494003526 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 768494003527 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 768494003528 Part of AAA domain; Region: AAA_19; pfam13245 768494003529 Family description; Region: UvrD_C_2; pfam13538 768494003530 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 768494003531 hypothetical protein; Provisional; Region: PRK07758 768494003532 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 768494003533 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 768494003534 Spore germination protein GerPC; Region: GerPC; pfam10737 768494003535 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 768494003536 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 768494003537 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 768494003538 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768494003539 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768494003540 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 768494003541 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768494003542 inhibitor-cofactor binding pocket; inhibition site 768494003543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494003544 catalytic residue [active] 768494003545 hypothetical protein; Provisional; Region: PRK13673 768494003546 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 768494003547 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 768494003548 active site 768494003549 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 768494003550 dimer interface [polypeptide binding]; other site 768494003551 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 768494003552 Ligand Binding Site [chemical binding]; other site 768494003553 Molecular Tunnel; other site 768494003554 ferrochelatase; Provisional; Region: PRK12435 768494003555 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 768494003556 C-terminal domain interface [polypeptide binding]; other site 768494003557 active site 768494003558 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 768494003559 active site 768494003560 N-terminal domain interface [polypeptide binding]; other site 768494003561 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 768494003562 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 768494003563 tetramer interface [polypeptide binding]; other site 768494003564 heme binding pocket [chemical binding]; other site 768494003565 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 768494003566 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 768494003567 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 768494003568 active site 768494003569 catalytic site [active] 768494003570 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768494003571 binding surface 768494003572 TPR motif; other site 768494003573 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768494003574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 768494003575 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 768494003576 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 768494003577 S1 domain; Region: S1_2; pfam13509 768494003578 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 768494003579 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768494003580 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768494003581 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494003582 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494003583 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768494003584 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 768494003585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494003586 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768494003587 active site 768494003588 motif I; other site 768494003589 motif II; other site 768494003590 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768494003591 YjzC-like protein; Region: YjzC; pfam14168 768494003592 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 768494003593 Clp amino terminal domain; Region: Clp_N; pfam02861 768494003594 Clp amino terminal domain; Region: Clp_N; pfam02861 768494003595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494003596 Walker A motif; other site 768494003597 ATP binding site [chemical binding]; other site 768494003598 Walker B motif; other site 768494003599 arginine finger; other site 768494003600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494003601 Walker A motif; other site 768494003602 ATP binding site [chemical binding]; other site 768494003603 Walker B motif; other site 768494003604 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768494003605 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 768494003606 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 768494003607 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 768494003608 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768494003609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494003610 NAD(P) binding site [chemical binding]; other site 768494003611 active site 768494003612 ComZ; Region: ComZ; pfam10815 768494003613 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768494003614 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 768494003615 dimer interface [polypeptide binding]; other site 768494003616 active site 768494003617 CoA binding pocket [chemical binding]; other site 768494003618 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 768494003619 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768494003620 dimer interface [polypeptide binding]; other site 768494003621 active site 768494003622 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 768494003623 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 768494003624 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 768494003625 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 768494003626 active site 768494003627 HIGH motif; other site 768494003628 dimer interface [polypeptide binding]; other site 768494003629 KMSKS motif; other site 768494003630 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 768494003631 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768494003632 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494003633 peptide binding site [polypeptide binding]; other site 768494003634 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768494003635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494003636 dimer interface [polypeptide binding]; other site 768494003637 conserved gate region; other site 768494003638 putative PBP binding loops; other site 768494003639 ABC-ATPase subunit interface; other site 768494003640 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768494003641 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 768494003642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494003643 dimer interface [polypeptide binding]; other site 768494003644 conserved gate region; other site 768494003645 putative PBP binding loops; other site 768494003646 ABC-ATPase subunit interface; other site 768494003647 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768494003648 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768494003649 Walker A/P-loop; other site 768494003650 ATP binding site [chemical binding]; other site 768494003651 Q-loop/lid; other site 768494003652 ABC transporter signature motif; other site 768494003653 Walker B; other site 768494003654 D-loop; other site 768494003655 H-loop/switch region; other site 768494003656 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768494003657 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 768494003658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768494003659 Walker A/P-loop; other site 768494003660 ATP binding site [chemical binding]; other site 768494003661 Q-loop/lid; other site 768494003662 ABC transporter signature motif; other site 768494003663 Walker B; other site 768494003664 D-loop; other site 768494003665 H-loop/switch region; other site 768494003666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768494003667 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 768494003668 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 768494003669 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768494003670 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494003671 peptide binding site [polypeptide binding]; other site 768494003672 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 768494003673 ArsC family; Region: ArsC; pfam03960 768494003674 putative catalytic residues [active] 768494003675 thiol/disulfide switch; other site 768494003676 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 768494003677 adaptor protein; Provisional; Region: PRK02315 768494003678 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 768494003679 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 768494003680 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 768494003681 putative active site [active] 768494003682 catalytic site [active] 768494003683 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 768494003684 putative active site [active] 768494003685 catalytic site [active] 768494003686 Competence protein CoiA-like family; Region: CoiA; cl11541 768494003687 oligoendopeptidase F; Region: pepF; TIGR00181 768494003688 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 768494003689 active site 768494003690 Zn binding site [ion binding]; other site 768494003691 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 768494003692 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 768494003693 catalytic residues [active] 768494003694 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 768494003695 apolar tunnel; other site 768494003696 heme binding site [chemical binding]; other site 768494003697 dimerization interface [polypeptide binding]; other site 768494003698 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 768494003699 putative active site [active] 768494003700 putative metal binding residues [ion binding]; other site 768494003701 signature motif; other site 768494003702 putative triphosphate binding site [ion binding]; other site 768494003703 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768494003704 synthetase active site [active] 768494003705 NTP binding site [chemical binding]; other site 768494003706 metal binding site [ion binding]; metal-binding site 768494003707 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 768494003708 ATP-NAD kinase; Region: NAD_kinase; pfam01513 768494003709 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768494003710 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768494003711 active site 768494003712 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 768494003713 trimer interface [polypeptide binding]; other site 768494003714 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 768494003715 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 768494003716 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 768494003717 active site 768494003718 metal binding site [ion binding]; metal-binding site 768494003719 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 768494003720 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 768494003721 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768494003722 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768494003723 active site 768494003724 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768494003725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494003726 S-adenosylmethionine binding site [chemical binding]; other site 768494003727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768494003728 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 768494003729 putative metal binding site; other site 768494003730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494003731 binding surface 768494003732 TPR motif; other site 768494003733 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768494003734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494003735 S-adenosylmethionine binding site [chemical binding]; other site 768494003736 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 768494003737 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 768494003738 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494003739 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 768494003740 active site 768494003741 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 768494003742 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 768494003743 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 768494003744 NAD binding site [chemical binding]; other site 768494003745 substrate binding site [chemical binding]; other site 768494003746 homodimer interface [polypeptide binding]; other site 768494003747 active site 768494003748 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 768494003749 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 768494003750 NADP binding site [chemical binding]; other site 768494003751 active site 768494003752 putative substrate binding site [chemical binding]; other site 768494003753 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 768494003754 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 768494003755 NAD binding site [chemical binding]; other site 768494003756 homotetramer interface [polypeptide binding]; other site 768494003757 homodimer interface [polypeptide binding]; other site 768494003758 substrate binding site [chemical binding]; other site 768494003759 active site 768494003760 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 768494003761 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 768494003762 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 768494003763 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 768494003764 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 768494003765 Part of AAA domain; Region: AAA_19; pfam13245 768494003766 Family description; Region: UvrD_C_2; pfam13538 768494003767 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 768494003768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494003769 Coenzyme A binding pocket [chemical binding]; other site 768494003770 hypothetical protein; Provisional; Region: PRK13679 768494003771 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 768494003772 Putative esterase; Region: Esterase; pfam00756 768494003773 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 768494003774 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768494003775 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 768494003776 EamA-like transporter family; Region: EamA; pfam00892 768494003777 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 768494003778 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 768494003779 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 768494003780 Na binding site [ion binding]; other site 768494003781 anthranilate synthase component I; Provisional; Region: PRK13570 768494003782 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768494003783 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 768494003784 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 768494003785 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 768494003786 glutamine binding [chemical binding]; other site 768494003787 catalytic triad [active] 768494003788 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 768494003789 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768494003790 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768494003791 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 768494003792 active site 768494003793 ribulose/triose binding site [chemical binding]; other site 768494003794 phosphate binding site [ion binding]; other site 768494003795 substrate (anthranilate) binding pocket [chemical binding]; other site 768494003796 product (indole) binding pocket [chemical binding]; other site 768494003797 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 768494003798 active site 768494003799 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 768494003800 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 768494003801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494003802 catalytic residue [active] 768494003803 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 768494003804 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 768494003805 substrate binding site [chemical binding]; other site 768494003806 active site 768494003807 catalytic residues [active] 768494003808 heterodimer interface [polypeptide binding]; other site 768494003809 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 768494003810 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 768494003811 L-lactate permease; Region: Lactate_perm; cl00701 768494003812 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 768494003813 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 768494003814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768494003815 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 768494003816 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494003817 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768494003818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494003819 Coenzyme A binding pocket [chemical binding]; other site 768494003820 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 768494003821 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 768494003822 NADPH bind site [chemical binding]; other site 768494003823 putative FMN binding site [chemical binding]; other site 768494003824 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 768494003825 putative FMN binding site [chemical binding]; other site 768494003826 NADPH bind site [chemical binding]; other site 768494003827 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 768494003828 YcaO-like family; Region: YcaO; pfam02624 768494003829 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 768494003830 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 768494003831 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 768494003832 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 768494003833 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768494003834 E3 interaction surface; other site 768494003835 lipoyl attachment site [posttranslational modification]; other site 768494003836 e3 binding domain; Region: E3_binding; pfam02817 768494003837 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768494003838 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 768494003839 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 768494003840 TPP-binding site [chemical binding]; other site 768494003841 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 768494003842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494003843 salt bridge; other site 768494003844 non-specific DNA binding site [nucleotide binding]; other site 768494003845 sequence-specific DNA binding site [nucleotide binding]; other site 768494003846 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 768494003847 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 768494003848 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 768494003849 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 768494003850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494003851 S-adenosylmethionine binding site [chemical binding]; other site 768494003852 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768494003853 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768494003854 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 768494003855 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 768494003856 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768494003857 Catalytic site [active] 768494003858 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 768494003859 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 768494003860 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 768494003861 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494003862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494003863 non-specific DNA binding site [nucleotide binding]; other site 768494003864 salt bridge; other site 768494003865 sequence-specific DNA binding site [nucleotide binding]; other site 768494003866 Anti-repressor SinI; Region: SinI; pfam08671 768494003867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 768494003868 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 768494003869 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 768494003870 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 768494003871 NAD(P) binding site [chemical binding]; other site 768494003872 catalytic residues [active] 768494003873 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768494003874 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 768494003875 Walker A/P-loop; other site 768494003876 ATP binding site [chemical binding]; other site 768494003877 Q-loop/lid; other site 768494003878 ABC transporter signature motif; other site 768494003879 Walker B; other site 768494003880 D-loop; other site 768494003881 H-loop/switch region; other site 768494003882 TOBE domain; Region: TOBE_2; pfam08402 768494003883 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768494003884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494003885 dimer interface [polypeptide binding]; other site 768494003886 conserved gate region; other site 768494003887 putative PBP binding loops; other site 768494003888 ABC-ATPase subunit interface; other site 768494003889 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768494003890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494003891 dimer interface [polypeptide binding]; other site 768494003892 conserved gate region; other site 768494003893 putative PBP binding loops; other site 768494003894 ABC-ATPase subunit interface; other site 768494003895 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 768494003896 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 768494003897 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 768494003898 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768494003899 active site 768494003900 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 768494003901 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 768494003902 potential frameshift: common BLAST hit: gi|291612209|ref|YP_003541023.1| ribosomal large subunit pseudouridine synthase 768494003903 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768494003904 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768494003905 active site 768494003906 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 768494003907 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 768494003908 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 768494003909 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 768494003910 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768494003911 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768494003912 Cysteine-rich domain; Region: CCG; pfam02754 768494003913 Cysteine-rich domain; Region: CCG; pfam02754 768494003914 FAD binding domain; Region: FAD_binding_4; pfam01565 768494003915 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 768494003916 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 768494003917 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 768494003918 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 768494003919 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 768494003920 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 768494003921 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494003922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494003923 active site 768494003924 phosphorylation site [posttranslational modification] 768494003925 intermolecular recognition site; other site 768494003926 dimerization interface [polypeptide binding]; other site 768494003927 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494003928 DNA binding site [nucleotide binding] 768494003929 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 768494003930 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494003931 dimerization interface [polypeptide binding]; other site 768494003932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494003933 dimer interface [polypeptide binding]; other site 768494003934 phosphorylation site [posttranslational modification] 768494003935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494003936 ATP binding site [chemical binding]; other site 768494003937 Mg2+ binding site [ion binding]; other site 768494003938 G-X-G motif; other site 768494003939 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768494003940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494003941 DNA-binding site [nucleotide binding]; DNA binding site 768494003942 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768494003943 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 768494003944 Cysteine-rich domain; Region: CCG; pfam02754 768494003945 Cysteine-rich domain; Region: CCG; pfam02754 768494003946 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 768494003947 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 768494003948 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 768494003949 Uncharacterized conserved protein [Function unknown]; Region: COG1556 768494003950 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 768494003951 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 768494003952 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 768494003953 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 768494003954 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 768494003955 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 768494003956 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 768494003957 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 768494003958 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 768494003959 dimer interaction site [polypeptide binding]; other site 768494003960 substrate-binding tunnel; other site 768494003961 active site 768494003962 catalytic site [active] 768494003963 substrate binding site [chemical binding]; other site 768494003964 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 768494003965 Transcriptional regulator PadR-like family; Region: PadR; cl17335 768494003966 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494003967 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 768494003968 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 768494003969 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768494003970 NAD(P) binding site [chemical binding]; other site 768494003971 homotetramer interface [polypeptide binding]; other site 768494003972 homodimer interface [polypeptide binding]; other site 768494003973 active site 768494003974 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 768494003975 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 768494003976 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 768494003977 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768494003978 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768494003979 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 768494003980 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 768494003981 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 768494003982 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 768494003983 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 768494003984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494003985 Q-loop/lid; other site 768494003986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494003987 ABC transporter signature motif; other site 768494003988 Walker B; other site 768494003989 D-loop; other site 768494003990 H-loop/switch region; other site 768494003991 TOBE domain; Region: TOBE_2; pfam08402 768494003992 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 768494003993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494003994 dimer interface [polypeptide binding]; other site 768494003995 conserved gate region; other site 768494003996 putative PBP binding loops; other site 768494003997 ABC-ATPase subunit interface; other site 768494003998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494003999 dimer interface [polypeptide binding]; other site 768494004000 conserved gate region; other site 768494004001 putative PBP binding loops; other site 768494004002 ABC-ATPase subunit interface; other site 768494004003 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 768494004004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494004005 motif II; other site 768494004006 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 768494004007 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768494004008 catalytic residue [active] 768494004009 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 768494004010 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768494004011 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 768494004012 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768494004013 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 768494004014 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 768494004015 heme-binding site [chemical binding]; other site 768494004016 Leucine rich repeat; Region: LRR_8; pfam13855 768494004017 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 768494004018 Leucine rich repeat; Region: LRR_8; pfam13855 768494004019 Leucine-rich repeats; other site 768494004020 Substrate binding site [chemical binding]; other site 768494004021 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 768494004022 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 768494004023 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 768494004024 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 768494004025 S-layer homology domain; Region: SLH; pfam00395 768494004026 S-layer homology domain; Region: SLH; pfam00395 768494004027 S-layer homology domain; Region: SLH; pfam00395 768494004028 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 768494004029 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 768494004030 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 768494004031 FOG: CBS domain [General function prediction only]; Region: COG0517 768494004032 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 768494004033 NodB motif; other site 768494004034 putative active site [active] 768494004035 putative catalytic site [active] 768494004036 Zn binding site [ion binding]; other site 768494004037 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 768494004038 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 768494004039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494004040 dimer interface [polypeptide binding]; other site 768494004041 phosphorylation site [posttranslational modification] 768494004042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494004043 ATP binding site [chemical binding]; other site 768494004044 Mg2+ binding site [ion binding]; other site 768494004045 G-X-G motif; other site 768494004046 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494004047 MarR family; Region: MarR; pfam01047 768494004048 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 768494004049 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 768494004050 active site 768494004051 Zn binding site [ion binding]; other site 768494004052 DinB superfamily; Region: DinB_2; pfam12867 768494004053 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 768494004054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494004055 dimer interface [polypeptide binding]; other site 768494004056 phosphorylation site [posttranslational modification] 768494004057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494004058 ATP binding site [chemical binding]; other site 768494004059 Mg2+ binding site [ion binding]; other site 768494004060 G-X-G motif; other site 768494004061 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 768494004062 Ligand Binding Site [chemical binding]; other site 768494004063 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 768494004064 active site 768494004065 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 768494004066 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 768494004067 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 768494004068 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 768494004069 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 768494004070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494004071 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768494004072 Coenzyme A binding pocket [chemical binding]; other site 768494004073 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 768494004074 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 768494004075 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 768494004076 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 768494004077 group I intron endonuclease; Region: grpIintron_endo; TIGR01453 768494004078 GIY-YIG motif/motif A; other site 768494004079 putative active site [active] 768494004080 catalytic site [active] 768494004081 putative metal binding site [ion binding]; other site 768494004082 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 768494004083 DNA binding site [nucleotide binding] 768494004084 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 768494004085 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 768494004086 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768494004087 dimer interface [polypeptide binding]; other site 768494004088 putative radical transfer pathway; other site 768494004089 diiron center [ion binding]; other site 768494004090 tyrosyl radical; other site 768494004091 Predicted transcriptional regulators [Transcription]; Region: COG1725 768494004092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494004093 DNA-binding site [nucleotide binding]; DNA binding site 768494004094 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 768494004095 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494004096 Walker A/P-loop; other site 768494004097 ATP binding site [chemical binding]; other site 768494004098 Q-loop/lid; other site 768494004099 ABC transporter signature motif; other site 768494004100 Walker B; other site 768494004101 D-loop; other site 768494004102 H-loop/switch region; other site 768494004103 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494004104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494004105 Walker A/P-loop; other site 768494004106 ATP binding site [chemical binding]; other site 768494004107 Q-loop/lid; other site 768494004108 ABC transporter signature motif; other site 768494004109 Walker B; other site 768494004110 D-loop; other site 768494004111 H-loop/switch region; other site 768494004112 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 768494004113 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 768494004114 CAAX protease self-immunity; Region: Abi; pfam02517 768494004115 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 768494004116 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 768494004117 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768494004118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494004119 putative DNA binding site [nucleotide binding]; other site 768494004120 putative Zn2+ binding site [ion binding]; other site 768494004121 AsnC family; Region: AsnC_trans_reg; pfam01037 768494004122 Uncharacterized conserved protein [Function unknown]; Region: COG2128 768494004123 Isochorismatase family; Region: Isochorismatase; pfam00857 768494004124 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768494004125 catalytic triad [active] 768494004126 conserved cis-peptide bond; other site 768494004127 SseB protein; Region: SseB; cl06279 768494004128 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 768494004129 dimer interface [polypeptide binding]; other site 768494004130 catalytic triad [active] 768494004131 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 768494004132 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 768494004133 FMN binding site [chemical binding]; other site 768494004134 substrate binding site [chemical binding]; other site 768494004135 putative catalytic residue [active] 768494004136 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 768494004137 DltD N-terminal region; Region: DltD_N; pfam04915 768494004138 DltD central region; Region: DltD_M; pfam04918 768494004139 DltD C-terminal region; Region: DltD_C; pfam04914 768494004140 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 768494004141 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 768494004142 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 768494004143 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 768494004144 acyl-activating enzyme (AAE) consensus motif; other site 768494004145 AMP binding site [chemical binding]; other site 768494004146 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 768494004147 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768494004148 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 768494004149 metal binding site [ion binding]; metal-binding site 768494004150 dimer interface [polypeptide binding]; other site 768494004151 flavodoxin; Provisional; Region: PRK06756 768494004152 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 768494004153 Phosphotransferase enzyme family; Region: APH; pfam01636 768494004154 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 768494004155 active site 768494004156 substrate binding site [chemical binding]; other site 768494004157 ATP binding site [chemical binding]; other site 768494004158 Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908 768494004159 multidrug efflux protein; Reviewed; Region: PRK01766 768494004160 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 768494004161 cation binding site [ion binding]; other site 768494004162 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 768494004163 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768494004164 catalytic residues [active] 768494004165 Regulatory protein YrvL; Region: YrvL; pfam14184 768494004166 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494004167 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 768494004168 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768494004169 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 768494004170 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 768494004171 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 768494004172 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 768494004173 hypothetical protein; Provisional; Region: PRK03094 768494004174 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 768494004175 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768494004176 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 768494004177 homodimer interface [polypeptide binding]; other site 768494004178 substrate-cofactor binding pocket; other site 768494004179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494004180 catalytic residue [active] 768494004181 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 768494004182 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768494004183 PYR/PP interface [polypeptide binding]; other site 768494004184 dimer interface [polypeptide binding]; other site 768494004185 TPP binding site [chemical binding]; other site 768494004186 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768494004187 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768494004188 TPP-binding site [chemical binding]; other site 768494004189 dimer interface [polypeptide binding]; other site 768494004190 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 768494004191 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 768494004192 putative valine binding site [chemical binding]; other site 768494004193 dimer interface [polypeptide binding]; other site 768494004194 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 768494004195 ketol-acid reductoisomerase; Provisional; Region: PRK05479 768494004196 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 768494004197 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 768494004198 2-isopropylmalate synthase; Validated; Region: PRK00915 768494004199 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 768494004200 active site 768494004201 catalytic residues [active] 768494004202 metal binding site [ion binding]; metal-binding site 768494004203 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 768494004204 tartrate dehydrogenase; Region: TTC; TIGR02089 768494004205 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 768494004206 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 768494004207 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 768494004208 substrate binding site [chemical binding]; other site 768494004209 ligand binding site [chemical binding]; other site 768494004210 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 768494004211 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 768494004212 substrate binding site [chemical binding]; other site 768494004213 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 768494004214 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 768494004215 dimer interface [polypeptide binding]; other site 768494004216 motif 1; other site 768494004217 active site 768494004218 motif 2; other site 768494004219 motif 3; other site 768494004220 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 768494004221 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 768494004222 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 768494004223 histidinol dehydrogenase; Region: hisD; TIGR00069 768494004224 NAD binding site [chemical binding]; other site 768494004225 dimerization interface [polypeptide binding]; other site 768494004226 product binding site; other site 768494004227 substrate binding site [chemical binding]; other site 768494004228 zinc binding site [ion binding]; other site 768494004229 catalytic residues [active] 768494004230 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 768494004231 putative active site pocket [active] 768494004232 4-fold oligomerization interface [polypeptide binding]; other site 768494004233 metal binding residues [ion binding]; metal-binding site 768494004234 3-fold/trimer interface [polypeptide binding]; other site 768494004235 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 768494004236 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 768494004237 putative active site [active] 768494004238 oxyanion strand; other site 768494004239 catalytic triad [active] 768494004240 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 768494004241 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 768494004242 catalytic residues [active] 768494004243 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 768494004244 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 768494004245 substrate binding site [chemical binding]; other site 768494004246 glutamase interaction surface [polypeptide binding]; other site 768494004247 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 768494004248 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 768494004249 metal binding site [ion binding]; metal-binding site 768494004250 histidinol-phosphatase; Validated; Region: PRK06740 768494004251 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 768494004252 dimer interface [polypeptide binding]; other site 768494004253 active site 768494004254 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 768494004255 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 768494004256 putative ligand binding site [chemical binding]; other site 768494004257 putative NAD binding site [chemical binding]; other site 768494004258 catalytic site [active] 768494004259 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 768494004260 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 768494004261 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 768494004262 Sulfatase; Region: Sulfatase; pfam00884 768494004263 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 768494004264 diaminopimelate decarboxylase; Region: lysA; TIGR01048 768494004265 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 768494004266 active site 768494004267 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768494004268 substrate binding site [chemical binding]; other site 768494004269 catalytic residues [active] 768494004270 dimer interface [polypeptide binding]; other site 768494004271 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 768494004272 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 768494004273 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768494004274 Active Sites [active] 768494004275 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 768494004276 ATP-sulfurylase; Region: ATPS; cd00517 768494004277 active site 768494004278 HXXH motif; other site 768494004279 flexible loop; other site 768494004280 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 768494004281 ligand-binding site [chemical binding]; other site 768494004282 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 768494004283 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768494004284 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768494004285 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 768494004286 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768494004287 diphthine synthase; Region: dph5; TIGR00522 768494004288 active site 768494004289 SAM binding site [chemical binding]; other site 768494004290 homodimer interface [polypeptide binding]; other site 768494004291 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 768494004292 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 768494004293 putative active site [active] 768494004294 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 768494004295 putative active site [active] 768494004296 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 768494004297 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 768494004298 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 768494004299 Na2 binding site [ion binding]; other site 768494004300 putative substrate binding site 1 [chemical binding]; other site 768494004301 Na binding site 1 [ion binding]; other site 768494004302 putative substrate binding site 2 [chemical binding]; other site 768494004303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 768494004304 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 768494004305 Peptidase family M23; Region: Peptidase_M23; pfam01551 768494004306 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768494004307 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 768494004308 Protein of unknown function (DUF402); Region: DUF402; cl00979 768494004309 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 768494004310 Vpu protein; Region: Vpu; pfam00558 768494004311 PspA/IM30 family; Region: PspA_IM30; pfam04012 768494004312 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 768494004313 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 768494004314 Histidine kinase; Region: HisKA_3; pfam07730 768494004315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494004316 ATP binding site [chemical binding]; other site 768494004317 Mg2+ binding site [ion binding]; other site 768494004318 G-X-G motif; other site 768494004319 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768494004320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494004321 active site 768494004322 phosphorylation site [posttranslational modification] 768494004323 intermolecular recognition site; other site 768494004324 dimerization interface [polypeptide binding]; other site 768494004325 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768494004326 DNA binding residues [nucleotide binding] 768494004327 dimerization interface [polypeptide binding]; other site 768494004328 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768494004329 E3 interaction surface; other site 768494004330 lipoyl attachment site [posttranslational modification]; other site 768494004331 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 768494004332 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768494004333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494004334 S-adenosylmethionine binding site [chemical binding]; other site 768494004335 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 768494004336 Peptidase family M50; Region: Peptidase_M50; pfam02163 768494004337 active site 768494004338 putative substrate binding region [chemical binding]; other site 768494004339 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 768494004340 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 768494004341 heme-binding site [chemical binding]; other site 768494004342 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 768494004343 FAD binding pocket [chemical binding]; other site 768494004344 FAD binding motif [chemical binding]; other site 768494004345 phosphate binding motif [ion binding]; other site 768494004346 beta-alpha-beta structure motif; other site 768494004347 NAD binding pocket [chemical binding]; other site 768494004348 Heme binding pocket [chemical binding]; other site 768494004349 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768494004350 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768494004351 ligand binding site [chemical binding]; other site 768494004352 flexible hinge region; other site 768494004353 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 768494004354 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768494004355 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768494004356 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 768494004357 Transglycosylase; Region: Transgly; pfam00912 768494004358 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 768494004359 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494004360 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 768494004361 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 768494004362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494004363 putative active site [active] 768494004364 heme pocket [chemical binding]; other site 768494004365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494004366 dimer interface [polypeptide binding]; other site 768494004367 phosphorylation site [posttranslational modification] 768494004368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494004369 ATP binding site [chemical binding]; other site 768494004370 Mg2+ binding site [ion binding]; other site 768494004371 G-X-G motif; other site 768494004372 Protein of unknown function DUF72; Region: DUF72; pfam01904 768494004373 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 768494004374 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768494004375 active site 768494004376 DNA binding site [nucleotide binding] 768494004377 Int/Topo IB signature motif; other site 768494004378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494004379 dimerization interface [polypeptide binding]; other site 768494004380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494004381 dimer interface [polypeptide binding]; other site 768494004382 phosphorylation site [posttranslational modification] 768494004383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494004384 ATP binding site [chemical binding]; other site 768494004385 Mg2+ binding site [ion binding]; other site 768494004386 G-X-G motif; other site 768494004387 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 768494004388 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 768494004389 Probable transposase; Region: OrfB_IS605; pfam01385 768494004390 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 768494004391 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 768494004392 Predicted integral membrane protein [Function unknown]; Region: COG0392 768494004393 Uncharacterized conserved protein [Function unknown]; Region: COG2898 768494004394 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 768494004395 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 768494004396 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 768494004397 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 768494004398 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 768494004399 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768494004400 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 768494004401 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 768494004402 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 768494004403 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 768494004404 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 768494004405 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768494004406 RNA binding surface [nucleotide binding]; other site 768494004407 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 768494004408 active site 768494004409 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 768494004410 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768494004411 catalytic residues [active] 768494004412 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 768494004413 ResB-like family; Region: ResB; pfam05140 768494004414 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 768494004415 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 768494004416 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494004417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494004418 active site 768494004419 phosphorylation site [posttranslational modification] 768494004420 intermolecular recognition site; other site 768494004421 dimerization interface [polypeptide binding]; other site 768494004422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494004423 DNA binding site [nucleotide binding] 768494004424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 768494004425 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494004426 dimerization interface [polypeptide binding]; other site 768494004427 PAS domain; Region: PAS; smart00091 768494004428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494004429 dimer interface [polypeptide binding]; other site 768494004430 phosphorylation site [posttranslational modification] 768494004431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494004432 ATP binding site [chemical binding]; other site 768494004433 Mg2+ binding site [ion binding]; other site 768494004434 G-X-G motif; other site 768494004435 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 768494004436 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 768494004437 Peptidase family M23; Region: Peptidase_M23; pfam01551 768494004438 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 768494004439 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768494004440 Predicted membrane protein [Function unknown]; Region: COG3601 768494004441 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 768494004442 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 768494004443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 768494004444 DEAD-like helicases superfamily; Region: DEXDc; smart00487 768494004445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768494004446 ATP binding site [chemical binding]; other site 768494004447 putative Mg++ binding site [ion binding]; other site 768494004448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494004449 nucleotide binding region [chemical binding]; other site 768494004450 ATP-binding site [chemical binding]; other site 768494004451 CAAX protease self-immunity; Region: Abi; pfam02517 768494004452 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768494004453 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 768494004454 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768494004455 active site 768494004456 metal binding site [ion binding]; metal-binding site 768494004457 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 768494004458 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768494004459 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 768494004460 DNA binding residues [nucleotide binding] 768494004461 B12 binding domain; Region: B12-binding_2; pfam02607 768494004462 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 768494004463 adaptor protein; Provisional; Region: PRK02899 768494004464 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 768494004465 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 768494004466 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 768494004467 NAD(P) binding site [chemical binding]; other site 768494004468 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 768494004469 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768494004470 amidase catalytic site [active] 768494004471 Zn binding residues [ion binding]; other site 768494004472 substrate binding site [chemical binding]; other site 768494004473 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 768494004474 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 768494004475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494004476 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 768494004477 active site 768494004478 homotetramer interface [polypeptide binding]; other site 768494004479 homodimer interface [polypeptide binding]; other site 768494004480 cytidylate kinase; Provisional; Region: cmk; PRK00023 768494004481 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 768494004482 CMP-binding site; other site 768494004483 The sites determining sugar specificity; other site 768494004484 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 768494004485 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 768494004486 RNA binding site [nucleotide binding]; other site 768494004487 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 768494004488 RNA binding site [nucleotide binding]; other site 768494004489 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 768494004490 RNA binding site [nucleotide binding]; other site 768494004491 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 768494004492 RNA binding site [nucleotide binding]; other site 768494004493 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 768494004494 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 768494004495 homotetramer interface [polypeptide binding]; other site 768494004496 FMN binding site [chemical binding]; other site 768494004497 homodimer contacts [polypeptide binding]; other site 768494004498 putative active site [active] 768494004499 putative substrate binding site [chemical binding]; other site 768494004500 YpzI-like protein; Region: YpzI; pfam14140 768494004501 YIEGIA protein; Region: YIEGIA; pfam14045 768494004502 GTP-binding protein Der; Reviewed; Region: PRK00093 768494004503 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 768494004504 G1 box; other site 768494004505 GTP/Mg2+ binding site [chemical binding]; other site 768494004506 Switch I region; other site 768494004507 G2 box; other site 768494004508 Switch II region; other site 768494004509 G3 box; other site 768494004510 G4 box; other site 768494004511 G5 box; other site 768494004512 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 768494004513 G1 box; other site 768494004514 GTP/Mg2+ binding site [chemical binding]; other site 768494004515 Switch I region; other site 768494004516 G2 box; other site 768494004517 G3 box; other site 768494004518 Switch II region; other site 768494004519 G4 box; other site 768494004520 G5 box; other site 768494004521 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 768494004522 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768494004523 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 768494004524 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 768494004525 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 768494004526 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 768494004527 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 768494004528 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768494004529 IHF dimer interface [polypeptide binding]; other site 768494004530 IHF - DNA interface [nucleotide binding]; other site 768494004531 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 768494004532 homodecamer interface [polypeptide binding]; other site 768494004533 GTP cyclohydrolase I; Provisional; Region: PLN03044 768494004534 active site 768494004535 putative catalytic site residues [active] 768494004536 zinc binding site [ion binding]; other site 768494004537 GTP-CH-I/GFRP interaction surface; other site 768494004538 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 768494004539 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 768494004540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494004541 S-adenosylmethionine binding site [chemical binding]; other site 768494004542 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768494004543 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768494004544 substrate binding pocket [chemical binding]; other site 768494004545 chain length determination region; other site 768494004546 substrate-Mg2+ binding site; other site 768494004547 catalytic residues [active] 768494004548 aspartate-rich region 1; other site 768494004549 active site lid residues [active] 768494004550 aspartate-rich region 2; other site 768494004551 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 768494004552 active site 768494004553 multimer interface [polypeptide binding]; other site 768494004554 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 768494004555 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 768494004556 Tetramer interface [polypeptide binding]; other site 768494004557 active site 768494004558 FMN-binding site [chemical binding]; other site 768494004559 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 768494004560 active site 768494004561 dimer interface [polypeptide binding]; other site 768494004562 metal binding site [ion binding]; metal-binding site 768494004563 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 768494004564 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494004565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494004566 homodimer interface [polypeptide binding]; other site 768494004567 catalytic residue [active] 768494004568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494004569 binding surface 768494004570 TPR motif; other site 768494004571 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 768494004572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494004573 binding surface 768494004574 TPR motif; other site 768494004575 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768494004576 TPR repeat; Region: TPR_11; pfam13414 768494004577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494004578 binding surface 768494004579 TPR motif; other site 768494004580 hypothetical protein; Provisional; Region: PRK03636 768494004581 UPF0302 domain; Region: UPF0302; pfam08864 768494004582 IDEAL domain; Region: IDEAL; pfam08858 768494004583 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 768494004584 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 768494004585 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 768494004586 iron-sulfur cluster [ion binding]; other site 768494004587 [2Fe-2S] cluster binding site [ion binding]; other site 768494004588 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 768494004589 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 768494004590 interchain domain interface [polypeptide binding]; other site 768494004591 intrachain domain interface; other site 768494004592 heme bH binding site [chemical binding]; other site 768494004593 Qi binding site; other site 768494004594 heme bL binding site [chemical binding]; other site 768494004595 Qo binding site; other site 768494004596 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 768494004597 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 768494004598 interchain domain interface [polypeptide binding]; other site 768494004599 intrachain domain interface; other site 768494004600 Qi binding site; other site 768494004601 Qo binding site; other site 768494004602 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768494004603 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768494004604 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 768494004605 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 768494004606 sporulation protein YpjB; Region: spore_ypjB; TIGR02878 768494004607 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 768494004608 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 768494004609 active site 768494004610 Fe-S cluster binding site [ion binding]; other site 768494004611 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768494004612 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494004613 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494004614 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768494004615 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 768494004616 homodimer interface [polypeptide binding]; other site 768494004617 metal binding site [ion binding]; metal-binding site 768494004618 dihydrodipicolinate reductase; Provisional; Region: PRK00048 768494004619 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 768494004620 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 768494004621 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 768494004622 active site 768494004623 dimer interfaces [polypeptide binding]; other site 768494004624 catalytic residues [active] 768494004625 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 768494004626 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 768494004627 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 768494004628 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 768494004629 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768494004630 active site 768494004631 NTP binding site [chemical binding]; other site 768494004632 metal binding triad [ion binding]; metal-binding site 768494004633 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768494004634 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 768494004635 Biotin operon repressor [Transcription]; Region: BirA; COG1654 768494004636 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 768494004637 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 768494004638 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 768494004639 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 768494004640 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 768494004641 oligomerization interface [polypeptide binding]; other site 768494004642 active site 768494004643 metal binding site [ion binding]; metal-binding site 768494004644 pantoate--beta-alanine ligase; Region: panC; TIGR00018 768494004645 Pantoate-beta-alanine ligase; Region: PanC; cd00560 768494004646 active site 768494004647 ATP-binding site [chemical binding]; other site 768494004648 pantoate-binding site; other site 768494004649 HXXH motif; other site 768494004650 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 768494004651 tetramerization interface [polypeptide binding]; other site 768494004652 active site 768494004653 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 768494004654 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768494004655 active site 768494004656 catalytic site [active] 768494004657 substrate binding site [chemical binding]; other site 768494004658 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 768494004659 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494004660 nucleotide binding region [chemical binding]; other site 768494004661 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 768494004662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 768494004663 aspartate aminotransferase; Provisional; Region: PRK05764 768494004664 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494004665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494004666 homodimer interface [polypeptide binding]; other site 768494004667 catalytic residue [active] 768494004668 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 768494004669 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 768494004670 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 768494004671 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 768494004672 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768494004673 minor groove reading motif; other site 768494004674 helix-hairpin-helix signature motif; other site 768494004675 substrate binding pocket [chemical binding]; other site 768494004676 active site 768494004677 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 768494004678 Transglycosylase; Region: Transgly; pfam00912 768494004679 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 768494004680 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768494004681 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768494004682 Interdomain contacts; other site 768494004683 Cytokine receptor motif; other site 768494004684 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 768494004685 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 768494004686 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 768494004687 YppF-like protein; Region: YppF; pfam14178 768494004688 YppG-like protein; Region: YppG; pfam14179 768494004689 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 768494004690 hypothetical protein; Provisional; Region: PRK13660 768494004691 cell division protein GpsB; Provisional; Region: PRK14127 768494004692 DivIVA domain; Region: DivI1A_domain; TIGR03544 768494004693 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 768494004694 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 768494004695 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 768494004696 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 768494004697 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 768494004698 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 768494004699 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 768494004700 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 768494004701 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 768494004702 active site 768494004703 Zn binding site [ion binding]; other site 768494004704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494004705 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494004706 Coenzyme A binding pocket [chemical binding]; other site 768494004707 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 768494004708 Phosphotransferase enzyme family; Region: APH; pfam01636 768494004709 putative active site [active] 768494004710 putative substrate binding site [chemical binding]; other site 768494004711 ATP binding site [chemical binding]; other site 768494004712 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768494004713 active site 768494004714 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768494004715 active site 768494004716 xanthine permease; Region: pbuX; TIGR03173 768494004717 Predicted membrane protein [Function unknown]; Region: COG2311 768494004718 Protein of unknown function (DUF418); Region: DUF418; cl12135 768494004719 Protein of unknown function (DUF418); Region: DUF418; pfam04235 768494004720 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 768494004721 Dynamin family; Region: Dynamin_N; pfam00350 768494004722 G1 box; other site 768494004723 GTP/Mg2+ binding site [chemical binding]; other site 768494004724 G2 box; other site 768494004725 Switch I region; other site 768494004726 G3 box; other site 768494004727 Switch II region; other site 768494004728 G4 box; other site 768494004729 G5 box; other site 768494004730 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 768494004731 Dynamin family; Region: Dynamin_N; pfam00350 768494004732 G1 box; other site 768494004733 GTP/Mg2+ binding site [chemical binding]; other site 768494004734 G2 box; other site 768494004735 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 768494004736 G3 box; other site 768494004737 Switch II region; other site 768494004738 GTP/Mg2+ binding site [chemical binding]; other site 768494004739 G4 box; other site 768494004740 G5 box; other site 768494004741 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 768494004742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494004743 Coenzyme A binding pocket [chemical binding]; other site 768494004744 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 768494004745 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 768494004746 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 768494004747 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 768494004748 active site residue [active] 768494004749 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 768494004750 active site residue [active] 768494004751 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 768494004752 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 768494004753 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 768494004754 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 768494004755 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768494004756 5'-3' exonuclease; Region: 53EXOc; smart00475 768494004757 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768494004758 active site 768494004759 metal binding site 1 [ion binding]; metal-binding site 768494004760 putative 5' ssDNA interaction site; other site 768494004761 metal binding site 3; metal-binding site 768494004762 metal binding site 2 [ion binding]; metal-binding site 768494004763 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768494004764 putative DNA binding site [nucleotide binding]; other site 768494004765 putative metal binding site [ion binding]; other site 768494004766 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 768494004767 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 768494004768 Chain length determinant protein; Region: Wzz; cl15801 768494004769 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 768494004770 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768494004771 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768494004772 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 768494004773 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 768494004774 O-Antigen ligase; Region: Wzy_C; pfam04932 768494004775 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768494004776 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768494004777 active site 768494004778 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768494004779 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768494004780 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 768494004781 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004782 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004783 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004784 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004785 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004786 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004787 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004788 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004789 Domain of unknown function DUF11; Region: DUF11; cl17728 768494004790 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004791 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004792 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004793 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004794 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004795 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004796 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004797 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004798 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004799 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004800 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004801 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004802 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004803 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004804 Domain of unknown function DUF11; Region: DUF11; cl17728 768494004805 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004806 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004807 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494004808 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768494004809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494004810 Coenzyme A binding pocket [chemical binding]; other site 768494004811 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768494004812 Isochorismatase family; Region: Isochorismatase; pfam00857 768494004813 catalytic triad [active] 768494004814 conserved cis-peptide bond; other site 768494004815 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768494004816 EamA-like transporter family; Region: EamA; pfam00892 768494004817 EamA-like transporter family; Region: EamA; cl17759 768494004818 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 768494004819 RNA/DNA hybrid binding site [nucleotide binding]; other site 768494004820 active site 768494004821 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 768494004822 active site 768494004823 catalytic residues [active] 768494004824 QueT transporter; Region: QueT; pfam06177 768494004825 hypothetical protein; Validated; Region: PRK07708 768494004826 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 768494004827 RNA/DNA hybrid binding site [nucleotide binding]; other site 768494004828 active site 768494004829 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 768494004830 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 768494004831 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768494004832 DNA-binding site [nucleotide binding]; DNA binding site 768494004833 RNA-binding motif; other site 768494004834 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 768494004835 LysE type translocator; Region: LysE; pfam01810 768494004836 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 768494004837 Protein of unknown function, DUF485; Region: DUF485; pfam04341 768494004838 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768494004839 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 768494004840 Na binding site [ion binding]; other site 768494004841 aminotransferase; Validated; Region: PRK07678 768494004842 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768494004843 inhibitor-cofactor binding pocket; inhibition site 768494004844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494004845 catalytic residue [active] 768494004846 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 768494004847 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 768494004848 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768494004849 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 768494004850 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494004851 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 768494004852 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 768494004853 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 768494004854 DNA binding residues [nucleotide binding] 768494004855 drug binding residues [chemical binding]; other site 768494004856 dimer interface [polypeptide binding]; other site 768494004857 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 768494004858 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 768494004859 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 768494004860 Predicted membrane protein [Function unknown]; Region: COG2323 768494004861 Uncharacterized conserved protein [Function unknown]; Region: COG1434 768494004862 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768494004863 putative active site [active] 768494004864 Tic20-like protein; Region: Tic20; pfam09685 768494004865 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 768494004866 dimer interface [polypeptide binding]; other site 768494004867 FMN binding site [chemical binding]; other site 768494004868 NADPH bind site [chemical binding]; other site 768494004869 DJ-1 family protein; Region: not_thiJ; TIGR01383 768494004870 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 768494004871 conserved cys residue [active] 768494004872 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768494004873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494004874 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494004875 putative substrate translocation pore; other site 768494004876 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494004877 dimerization interface [polypeptide binding]; other site 768494004878 putative DNA binding site [nucleotide binding]; other site 768494004879 putative Zn2+ binding site [ion binding]; other site 768494004880 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494004881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494004882 putative substrate translocation pore; other site 768494004883 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768494004884 active site 768494004885 metal binding site [ion binding]; metal-binding site 768494004886 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494004887 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 768494004888 bacterial Hfq-like; Region: Hfq; cd01716 768494004889 hexamer interface [polypeptide binding]; other site 768494004890 Sm1 motif; other site 768494004891 RNA binding site [nucleotide binding]; other site 768494004892 Sm2 motif; other site 768494004893 HD domain; Region: HD_3; pfam13023 768494004894 flagellar motor protein MotP; Reviewed; Region: PRK06743 768494004895 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 768494004896 flagellar motor protein MotS; Reviewed; Region: PRK06742 768494004897 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768494004898 ligand binding site [chemical binding]; other site 768494004899 Response regulator receiver domain; Region: Response_reg; pfam00072 768494004900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494004901 active site 768494004902 phosphorylation site [posttranslational modification] 768494004903 intermolecular recognition site; other site 768494004904 dimerization interface [polypeptide binding]; other site 768494004905 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768494004906 putative binding surface; other site 768494004907 active site 768494004908 P2 response regulator binding domain; Region: P2; pfam07194 768494004909 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 768494004910 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 768494004911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494004912 ATP binding site [chemical binding]; other site 768494004913 Mg2+ binding site [ion binding]; other site 768494004914 G-X-G motif; other site 768494004915 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 768494004916 flagellar motor switch protein; Reviewed; Region: PRK06782 768494004917 CheC-like family; Region: CheC; pfam04509 768494004918 CheC-like family; Region: CheC; pfam04509 768494004919 CheC-like family; Region: CheC; pfam04509 768494004920 CheC-like family; Region: CheC; pfam04509 768494004921 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 768494004922 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 768494004923 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 768494004924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494004925 Protein of unknown function (DUF327); Region: DUF327; pfam03885 768494004926 Glutamate-cysteine ligase; Region: GshA; pfam08886 768494004927 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 768494004928 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768494004929 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768494004930 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 768494004931 flagellar capping protein; Validated; Region: fliD; PRK06798 768494004932 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 768494004933 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 768494004934 Flagellar protein FliS; Region: FliS; cl00654 768494004935 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 768494004936 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 768494004937 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 768494004938 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768494004939 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 768494004940 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 768494004941 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 768494004942 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 768494004943 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 768494004944 FliG C-terminal domain; Region: FliG_C; pfam01706 768494004945 flagellar assembly protein H; Validated; Region: fliH; PRK06800 768494004946 Flagellar assembly protein FliH; Region: FliH; pfam02108 768494004947 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 768494004948 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768494004949 Walker A motif; other site 768494004950 ATP binding site [chemical binding]; other site 768494004951 Walker B motif; other site 768494004952 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 768494004953 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 768494004954 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 768494004955 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 768494004956 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768494004957 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768494004958 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 768494004959 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 768494004960 putative CheA interaction surface; other site 768494004961 Response regulator receiver domain; Region: Response_reg; pfam00072 768494004962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494004963 active site 768494004964 phosphorylation site [posttranslational modification] 768494004965 intermolecular recognition site; other site 768494004966 dimerization interface [polypeptide binding]; other site 768494004967 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 768494004968 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768494004969 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494004970 active site 768494004971 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768494004972 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768494004973 TPR repeat; Region: TPR_11; pfam13414 768494004974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494004975 binding surface 768494004976 TPR motif; other site 768494004977 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 768494004978 putative metal binding site; other site 768494004979 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768494004980 putative transposase OrfB; Reviewed; Region: PHA02517 768494004981 flagellin; Provisional; Region: PRK12807 768494004982 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768494004983 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 768494004984 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768494004985 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768494004986 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768494004987 catalytic residue [active] 768494004988 flagellar motor switch protein; Validated; Region: PRK06789 768494004989 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 768494004990 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 768494004991 flagellar motor switch protein; Validated; Region: PRK06788 768494004992 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 768494004993 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 768494004994 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 768494004995 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 768494004996 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 768494004997 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 768494004998 FHIPEP family; Region: FHIPEP; pfam00771 768494004999 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 768494005000 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768494005001 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 768494005002 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 768494005003 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 768494005004 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 768494005005 Predicted transcriptional regulators [Transcription]; Region: COG1378 768494005006 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 768494005007 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 768494005008 C-terminal domain interface [polypeptide binding]; other site 768494005009 sugar binding site [chemical binding]; other site 768494005010 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 768494005011 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 768494005012 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 768494005013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494005014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494005015 Dienelactone hydrolase family; Region: DLH; pfam01738 768494005016 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 768494005017 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 768494005018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494005019 non-specific DNA binding site [nucleotide binding]; other site 768494005020 salt bridge; other site 768494005021 sequence-specific DNA binding site [nucleotide binding]; other site 768494005022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494005023 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494005024 putative substrate translocation pore; other site 768494005025 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 768494005026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768494005027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494005028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768494005029 dimerization interface [polypeptide binding]; other site 768494005030 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768494005031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494005032 Walker A/P-loop; other site 768494005033 ATP binding site [chemical binding]; other site 768494005034 Q-loop/lid; other site 768494005035 ABC transporter signature motif; other site 768494005036 Walker B; other site 768494005037 D-loop; other site 768494005038 H-loop/switch region; other site 768494005039 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 768494005040 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768494005041 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768494005042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494005043 dimer interface [polypeptide binding]; other site 768494005044 conserved gate region; other site 768494005045 putative PBP binding loops; other site 768494005046 ABC-ATPase subunit interface; other site 768494005047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494005048 dimer interface [polypeptide binding]; other site 768494005049 conserved gate region; other site 768494005050 putative PBP binding loops; other site 768494005051 ABC-ATPase subunit interface; other site 768494005052 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 768494005053 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 768494005054 Beta-Casp domain; Region: Beta-Casp; smart01027 768494005055 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 768494005056 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 768494005057 Cupin; Region: Cupin_1; smart00835 768494005058 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 768494005059 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 768494005060 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768494005061 catalytic core [active] 768494005062 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768494005063 hypothetical protein; Provisional; Region: PRK09272 768494005064 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 768494005065 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 768494005066 active site 768494005067 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 768494005068 dimer interface [polypeptide binding]; other site 768494005069 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 768494005070 Ligand Binding Site [chemical binding]; other site 768494005071 Molecular Tunnel; other site 768494005072 RNA polymerase factor sigma-70; Validated; Region: PRK06811 768494005073 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494005074 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494005075 DNA binding residues [nucleotide binding] 768494005076 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 768494005077 VPS10 domain; Region: VPS10; smart00602 768494005078 VPS10 domain; Region: VPS10; smart00602 768494005079 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 768494005080 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 768494005081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494005082 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 768494005083 DNA-binding site [nucleotide binding]; DNA binding site 768494005084 FCD domain; Region: FCD; pfam07729 768494005085 EamA-like transporter family; Region: EamA; pfam00892 768494005086 EamA-like transporter family; Region: EamA; pfam00892 768494005087 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768494005088 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 768494005089 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 768494005090 Predicted permeases [General function prediction only]; Region: COG0701 768494005091 TIGR03943 family protein; Region: TIGR03943 768494005092 Methyltransferase domain; Region: Methyltransf_24; pfam13578 768494005093 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 768494005094 fumarate hydratase; Reviewed; Region: fumC; PRK00485 768494005095 Class II fumarases; Region: Fumarase_classII; cd01362 768494005096 active site 768494005097 tetramer interface [polypeptide binding]; other site 768494005098 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 768494005099 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 768494005100 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 768494005101 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 768494005102 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 768494005103 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 768494005104 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 768494005105 active site pocket [active] 768494005106 oxyanion hole [active] 768494005107 catalytic triad [active] 768494005108 active site nucleophile [active] 768494005109 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 768494005110 Penicillinase repressor; Region: Pencillinase_R; pfam03965 768494005111 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 768494005112 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 768494005113 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 768494005114 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 768494005115 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768494005116 catalytic residues [active] 768494005117 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 768494005118 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768494005119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494005120 non-specific DNA binding site [nucleotide binding]; other site 768494005121 salt bridge; other site 768494005122 sequence-specific DNA binding site [nucleotide binding]; other site 768494005123 Cupin domain; Region: Cupin_2; pfam07883 768494005124 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 768494005125 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 768494005126 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 768494005127 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 768494005128 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768494005129 catalytic residue [active] 768494005130 Protein of unknown function (DUF445); Region: DUF445; pfam04286 768494005131 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 768494005132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494005133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494005134 DNA binding residues [nucleotide binding] 768494005135 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768494005136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494005137 active site 768494005138 phosphorylation site [posttranslational modification] 768494005139 intermolecular recognition site; other site 768494005140 dimerization interface [polypeptide binding]; other site 768494005141 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768494005142 DNA binding residues [nucleotide binding] 768494005143 dimerization interface [polypeptide binding]; other site 768494005144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 768494005145 Histidine kinase; Region: HisKA_3; pfam07730 768494005146 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494005147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494005148 Walker A/P-loop; other site 768494005149 ATP binding site [chemical binding]; other site 768494005150 Q-loop/lid; other site 768494005151 ABC transporter signature motif; other site 768494005152 Walker B; other site 768494005153 D-loop; other site 768494005154 H-loop/switch region; other site 768494005155 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768494005156 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768494005157 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 768494005158 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768494005159 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 768494005160 PLD-like domain; Region: PLDc_2; pfam13091 768494005161 putative active site [active] 768494005162 catalytic site [active] 768494005163 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 768494005164 PLD-like domain; Region: PLDc_2; pfam13091 768494005165 putative active site [active] 768494005166 catalytic site [active] 768494005167 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 768494005168 putative nucleotide binding site [chemical binding]; other site 768494005169 uridine monophosphate binding site [chemical binding]; other site 768494005170 homohexameric interface [polypeptide binding]; other site 768494005171 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768494005172 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 768494005173 aspartate ammonia-lyase; Provisional; Region: PRK14515 768494005174 Aspartase; Region: Aspartase; cd01357 768494005175 active sites [active] 768494005176 tetramer interface [polypeptide binding]; other site 768494005177 malate dehydrogenase; Provisional; Region: PRK13529 768494005178 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768494005179 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 768494005180 NAD(P) binding site [chemical binding]; other site 768494005181 Fanconi anemia ID complex proteins FANCI and FANCD2; Region: FANC; cl17018 768494005182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494005183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494005184 ATP binding site [chemical binding]; other site 768494005185 Mg2+ binding site [ion binding]; other site 768494005186 G-X-G motif; other site 768494005187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494005188 Response regulator receiver domain; Region: Response_reg; pfam00072 768494005189 active site 768494005190 phosphorylation site [posttranslational modification] 768494005191 intermolecular recognition site; other site 768494005192 dimerization interface [polypeptide binding]; other site 768494005193 YcbB domain; Region: YcbB; pfam08664 768494005194 SWIM zinc finger; Region: SWIM; pfam04434 768494005195 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 768494005196 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 768494005197 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768494005198 ATP binding site [chemical binding]; other site 768494005199 putative Mg++ binding site [ion binding]; other site 768494005200 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494005201 nucleotide binding region [chemical binding]; other site 768494005202 ATP-binding site [chemical binding]; other site 768494005203 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 768494005204 dimer interface [polypeptide binding]; other site 768494005205 active site 768494005206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494005207 non-specific DNA binding site [nucleotide binding]; other site 768494005208 salt bridge; other site 768494005209 sequence-specific DNA binding site [nucleotide binding]; other site 768494005210 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 768494005211 putative dimer interface [polypeptide binding]; other site 768494005212 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494005213 aspartate kinase; Reviewed; Region: PRK06635 768494005214 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 768494005215 putative nucleotide binding site [chemical binding]; other site 768494005216 putative catalytic residues [active] 768494005217 putative Mg ion binding site [ion binding]; other site 768494005218 putative aspartate binding site [chemical binding]; other site 768494005219 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 768494005220 putative allosteric regulatory site; other site 768494005221 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 768494005222 putative allosteric regulatory residue; other site 768494005223 DoxX-like family; Region: DoxX_3; pfam13781 768494005224 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 768494005225 YndJ-like protein; Region: YndJ; pfam14158 768494005226 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 768494005227 putative active site [active] 768494005228 nucleotide binding site [chemical binding]; other site 768494005229 nudix motif; other site 768494005230 putative metal binding site [ion binding]; other site 768494005231 S-layer homology domain; Region: SLH; pfam00395 768494005232 S-layer homology domain; Region: SLH; pfam00395 768494005233 S-layer homology domain; Region: SLH; pfam00395 768494005234 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 768494005235 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768494005236 active site 768494005237 metal binding site [ion binding]; metal-binding site 768494005238 S-layer homology domain; Region: SLH; pfam00395 768494005239 S-layer homology domain; Region: SLH; pfam00395 768494005240 S-layer homology domain; Region: SLH; pfam00395 768494005241 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 768494005242 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494005243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494005244 putative substrate translocation pore; other site 768494005245 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 768494005246 Carbon starvation protein CstA; Region: CstA; pfam02554 768494005247 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 768494005248 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 768494005249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 768494005250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494005251 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 768494005252 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768494005253 dimer interface [polypeptide binding]; other site 768494005254 active site 768494005255 CoA binding pocket [chemical binding]; other site 768494005256 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 768494005257 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 768494005258 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 768494005259 HflX GTPase family; Region: HflX; cd01878 768494005260 G1 box; other site 768494005261 GTP/Mg2+ binding site [chemical binding]; other site 768494005262 Switch I region; other site 768494005263 G2 box; other site 768494005264 G3 box; other site 768494005265 Switch II region; other site 768494005266 G4 box; other site 768494005267 G5 box; other site 768494005268 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 768494005269 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768494005270 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494005271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494005272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494005273 putative substrate translocation pore; other site 768494005274 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768494005275 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768494005276 dimer interface [polypeptide binding]; other site 768494005277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494005278 catalytic residue [active] 768494005279 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494005280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494005281 Coenzyme A binding pocket [chemical binding]; other site 768494005282 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 768494005283 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768494005284 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 768494005285 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 768494005286 Na2 binding site [ion binding]; other site 768494005287 putative substrate binding site 1 [chemical binding]; other site 768494005288 Na binding site 1 [ion binding]; other site 768494005289 putative substrate binding site 2 [chemical binding]; other site 768494005290 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 768494005291 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 768494005292 NodB motif; other site 768494005293 putative active site [active] 768494005294 putative catalytic site [active] 768494005295 putative Zn binding site [ion binding]; other site 768494005296 Mor transcription activator family; Region: Mor; cl02360 768494005297 Predicted membrane protein [Function unknown]; Region: COG2323 768494005298 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 768494005299 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 768494005300 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 768494005301 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 768494005302 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 768494005303 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 768494005304 methionine sulfoxide reductase A; Provisional; Region: PRK14054 768494005305 short chain dehydrogenase; Provisional; Region: PRK12747 768494005306 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 768494005307 NADP binding site [chemical binding]; other site 768494005308 homodimer interface [polypeptide binding]; other site 768494005309 active site 768494005310 substrate binding site [chemical binding]; other site 768494005311 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768494005312 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 768494005313 homodimer interface [polypeptide binding]; other site 768494005314 substrate-cofactor binding pocket; other site 768494005315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494005316 catalytic residue [active] 768494005317 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 768494005318 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768494005319 PYR/PP interface [polypeptide binding]; other site 768494005320 dimer interface [polypeptide binding]; other site 768494005321 TPP binding site [chemical binding]; other site 768494005322 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768494005323 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768494005324 TPP-binding site [chemical binding]; other site 768494005325 dimer interface [polypeptide binding]; other site 768494005326 acetolactate synthase 1 regulatory subunit; Validated; Region: PRK06737 768494005327 ketol-acid reductoisomerase; Provisional; Region: PRK05479 768494005328 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 768494005329 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 768494005330 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 768494005331 threonine dehydratase; Validated; Region: PRK08639 768494005332 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768494005333 tetramer interface [polypeptide binding]; other site 768494005334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494005335 catalytic residue [active] 768494005336 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 768494005337 putative Ile/Val binding site [chemical binding]; other site 768494005338 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 768494005339 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 768494005340 putative active site [active] 768494005341 putative metal binding site [ion binding]; other site 768494005342 Protein of unknown function (DUF554); Region: DUF554; pfam04474 768494005343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494005344 Coenzyme A binding pocket [chemical binding]; other site 768494005345 drug efflux system protein MdtG; Provisional; Region: PRK09874 768494005346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494005347 putative substrate translocation pore; other site 768494005348 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 768494005349 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 768494005350 putative active site [active] 768494005351 metal binding site [ion binding]; metal-binding site 768494005352 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 768494005353 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768494005354 LytTr DNA-binding domain; Region: LytTR; pfam04397 768494005355 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 768494005356 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 768494005357 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 768494005358 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 768494005359 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768494005360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494005361 Coenzyme A binding pocket [chemical binding]; other site 768494005362 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 768494005363 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 768494005364 active site 768494005365 putative substrate binding pocket [chemical binding]; other site 768494005366 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768494005367 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494005368 peptide binding site [polypeptide binding]; other site 768494005369 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768494005370 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 768494005371 hypothetical protein; Provisional; Region: PRK06922 768494005372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494005373 S-adenosylmethionine binding site [chemical binding]; other site 768494005374 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 768494005375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494005376 FeS/SAM binding site; other site 768494005377 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 768494005378 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494005379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494005380 Coenzyme A binding pocket [chemical binding]; other site 768494005381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494005382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494005383 active site 768494005384 phosphorylation site [posttranslational modification] 768494005385 intermolecular recognition site; other site 768494005386 dimerization interface [polypeptide binding]; other site 768494005387 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494005388 DNA binding site [nucleotide binding] 768494005389 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494005390 dimerization interface [polypeptide binding]; other site 768494005391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494005392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494005393 dimer interface [polypeptide binding]; other site 768494005394 phosphorylation site [posttranslational modification] 768494005395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494005396 ATP binding site [chemical binding]; other site 768494005397 Mg2+ binding site [ion binding]; other site 768494005398 G-X-G motif; other site 768494005399 Peptidase family M23; Region: Peptidase_M23; pfam01551 768494005400 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 768494005401 manganese transport protein MntH; Reviewed; Region: PRK00701 768494005402 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 768494005403 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 768494005404 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 768494005405 active site residue [active] 768494005406 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 768494005407 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 768494005408 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768494005409 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768494005410 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768494005411 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 768494005412 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 768494005413 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 768494005414 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768494005415 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 768494005416 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494005417 DNA binding residues [nucleotide binding] 768494005418 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 768494005419 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 768494005420 intersubunit interface [polypeptide binding]; other site 768494005421 active site 768494005422 catalytic residue [active] 768494005423 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768494005424 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768494005425 Nucleoside recognition; Region: Gate; pfam07670 768494005426 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768494005427 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 768494005428 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768494005429 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768494005430 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 768494005431 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768494005432 active site 768494005433 catalytic motif [active] 768494005434 Zn binding site [ion binding]; other site 768494005435 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 768494005436 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 768494005437 Family description; Region: DsbD_2; pfam13386 768494005438 VPS10 domain; Region: VPS10; smart00602 768494005439 proline aminopeptidase P II; Provisional; Region: PRK10879 768494005440 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 768494005441 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 768494005442 active site 768494005443 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 768494005444 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 768494005445 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 768494005446 Multicopper oxidase; Region: Cu-oxidase; pfam00394 768494005447 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 768494005448 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494005449 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494005450 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494005451 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494005452 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 768494005453 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494005454 Peptidase family M23; Region: Peptidase_M23; pfam01551 768494005455 DNA topoisomerase III; Provisional; Region: PRK07726 768494005456 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768494005457 active site 768494005458 putative interdomain interaction site [polypeptide binding]; other site 768494005459 putative metal-binding site [ion binding]; other site 768494005460 putative nucleotide binding site [chemical binding]; other site 768494005461 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768494005462 domain I; other site 768494005463 DNA binding groove [nucleotide binding] 768494005464 phosphate binding site [ion binding]; other site 768494005465 domain II; other site 768494005466 domain III; other site 768494005467 nucleotide binding site [chemical binding]; other site 768494005468 catalytic site [active] 768494005469 domain IV; other site 768494005470 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768494005471 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 768494005472 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 768494005473 Sodium Bile acid symporter family; Region: SBF; cl17470 768494005474 azoreductase; Provisional; Region: PRK13555 768494005475 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 768494005476 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 768494005477 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494005478 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 768494005479 dimer interface [polypeptide binding]; other site 768494005480 substrate binding site [chemical binding]; other site 768494005481 metal binding site [ion binding]; metal-binding site 768494005482 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 768494005483 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 768494005484 YtkA-like; Region: YtkA; pfam13115 768494005485 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 768494005486 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768494005487 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 768494005488 EamA-like transporter family; Region: EamA; pfam00892 768494005489 EamA-like transporter family; Region: EamA; pfam00892 768494005490 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768494005491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494005492 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768494005493 dimerization interface [polypeptide binding]; other site 768494005494 Predicted transcriptional regulator [Transcription]; Region: COG1959 768494005495 Transcriptional regulator; Region: Rrf2; pfam02082 768494005496 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 768494005497 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 768494005498 catalytic residues [active] 768494005499 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 768494005500 dimer interface [polypeptide binding]; other site 768494005501 FMN binding site [chemical binding]; other site 768494005502 amidase; Provisional; Region: PRK06707 768494005503 Amidase; Region: Amidase; cl11426 768494005504 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768494005505 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 768494005506 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 768494005507 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768494005508 NAD binding site [chemical binding]; other site 768494005509 dimer interface [polypeptide binding]; other site 768494005510 substrate binding site [chemical binding]; other site 768494005511 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 768494005512 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768494005513 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768494005514 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 768494005515 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 768494005516 S-layer homology domain; Region: SLH; pfam00395 768494005517 S-layer homology domain; Region: SLH; pfam00395 768494005518 S-layer homology domain; Region: SLH; pfam00395 768494005519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494005520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494005521 acyl-CoA synthetase; Validated; Region: PRK06839 768494005522 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768494005523 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 768494005524 acyl-activating enzyme (AAE) consensus motif; other site 768494005525 putative AMP binding site [chemical binding]; other site 768494005526 putative active site [active] 768494005527 putative CoA binding site [chemical binding]; other site 768494005528 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 768494005529 dimer interaction site [polypeptide binding]; other site 768494005530 substrate-binding tunnel; other site 768494005531 active site 768494005532 catalytic site [active] 768494005533 substrate binding site [chemical binding]; other site 768494005534 hypothetical protein; Validated; Region: PRK06840 768494005535 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 768494005536 active site 768494005537 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 768494005538 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 768494005539 putative ligand binding site [chemical binding]; other site 768494005540 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 768494005541 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768494005542 Walker A/P-loop; other site 768494005543 ATP binding site [chemical binding]; other site 768494005544 Q-loop/lid; other site 768494005545 ABC transporter signature motif; other site 768494005546 Walker B; other site 768494005547 D-loop; other site 768494005548 H-loop/switch region; other site 768494005549 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768494005550 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768494005551 Walker A/P-loop; other site 768494005552 ATP binding site [chemical binding]; other site 768494005553 Q-loop/lid; other site 768494005554 ABC transporter signature motif; other site 768494005555 Walker B; other site 768494005556 D-loop; other site 768494005557 H-loop/switch region; other site 768494005558 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768494005559 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768494005560 TM-ABC transporter signature motif; other site 768494005561 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 768494005562 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768494005563 TM-ABC transporter signature motif; other site 768494005564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494005565 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 768494005566 LysR substrate binding domain; Region: LysR_substrate; pfam03466 768494005567 dimerization interface [polypeptide binding]; other site 768494005568 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 768494005569 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494005570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494005571 putative Zn2+ binding site [ion binding]; other site 768494005572 putative DNA binding site [nucleotide binding]; other site 768494005573 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 768494005574 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768494005575 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 768494005576 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 768494005577 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 768494005578 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768494005579 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768494005580 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 768494005581 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494005582 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 768494005583 Walker A/P-loop; other site 768494005584 ATP binding site [chemical binding]; other site 768494005585 Q-loop/lid; other site 768494005586 ABC transporter signature motif; other site 768494005587 Walker B; other site 768494005588 D-loop; other site 768494005589 H-loop/switch region; other site 768494005590 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 768494005591 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494005592 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 768494005593 Walker A/P-loop; other site 768494005594 ATP binding site [chemical binding]; other site 768494005595 Q-loop/lid; other site 768494005596 ABC transporter signature motif; other site 768494005597 Walker B; other site 768494005598 D-loop; other site 768494005599 H-loop/switch region; other site 768494005600 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 768494005601 putative dimer interface [polypeptide binding]; other site 768494005602 catalytic triad [active] 768494005603 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768494005604 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768494005605 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 768494005606 dimer interface [polypeptide binding]; other site 768494005607 FMN binding site [chemical binding]; other site 768494005608 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494005609 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494005610 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494005611 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768494005612 NlpC/P60 family; Region: NLPC_P60; pfam00877 768494005613 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768494005614 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768494005615 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494005616 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494005617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494005618 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 768494005619 Walker A/P-loop; other site 768494005620 ATP binding site [chemical binding]; other site 768494005621 Q-loop/lid; other site 768494005622 ABC transporter signature motif; other site 768494005623 Walker B; other site 768494005624 D-loop; other site 768494005625 H-loop/switch region; other site 768494005626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494005627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494005628 active site 768494005629 phosphorylation site [posttranslational modification] 768494005630 intermolecular recognition site; other site 768494005631 dimerization interface [polypeptide binding]; other site 768494005632 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494005633 DNA binding site [nucleotide binding] 768494005634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494005635 dimerization interface [polypeptide binding]; other site 768494005636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494005637 dimer interface [polypeptide binding]; other site 768494005638 phosphorylation site [posttranslational modification] 768494005639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494005640 ATP binding site [chemical binding]; other site 768494005641 Mg2+ binding site [ion binding]; other site 768494005642 G-X-G motif; other site 768494005643 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 768494005644 classical (c) SDRs; Region: SDR_c; cd05233 768494005645 NAD(P) binding site [chemical binding]; other site 768494005646 active site 768494005647 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 768494005648 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 768494005649 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 768494005650 NodB motif; other site 768494005651 active site 768494005652 catalytic site [active] 768494005653 metal binding site [ion binding]; metal-binding site 768494005654 SdpI/YhfL protein family; Region: SdpI; pfam13630 768494005655 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 768494005656 nudix motif; other site 768494005657 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 768494005658 homoserine dehydrogenase; Provisional; Region: PRK06349 768494005659 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768494005660 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768494005661 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 768494005662 threonine synthase; Reviewed; Region: PRK06721 768494005663 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 768494005664 homodimer interface [polypeptide binding]; other site 768494005665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494005666 catalytic residue [active] 768494005667 homoserine kinase; Provisional; Region: PRK01212 768494005668 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 768494005669 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768494005670 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 768494005671 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 768494005672 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494005673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494005674 active site 768494005675 phosphorylation site [posttranslational modification] 768494005676 intermolecular recognition site; other site 768494005677 dimerization interface [polypeptide binding]; other site 768494005678 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494005679 DNA binding site [nucleotide binding] 768494005680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494005681 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494005682 dimerization interface [polypeptide binding]; other site 768494005683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494005684 dimer interface [polypeptide binding]; other site 768494005685 phosphorylation site [posttranslational modification] 768494005686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494005687 ATP binding site [chemical binding]; other site 768494005688 Mg2+ binding site [ion binding]; other site 768494005689 G-X-G motif; other site 768494005690 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 768494005691 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 768494005692 NodB motif; other site 768494005693 active site 768494005694 catalytic site [active] 768494005695 Zn binding site [ion binding]; other site 768494005696 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 768494005697 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 768494005698 MgtC family; Region: MgtC; pfam02308 768494005699 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768494005700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494005701 Coenzyme A binding pocket [chemical binding]; other site 768494005702 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 768494005703 IucA / IucC family; Region: IucA_IucC; pfam04183 768494005704 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768494005705 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 768494005706 IucA / IucC family; Region: IucA_IucC; pfam04183 768494005707 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768494005708 acyl-CoA synthetase; Validated; Region: PRK08308 768494005709 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768494005710 acyl-activating enzyme (AAE) consensus motif; other site 768494005711 AMP binding site [chemical binding]; other site 768494005712 active site 768494005713 CoA binding site [chemical binding]; other site 768494005714 acyl carrier protein; Provisional; Region: PRK07639 768494005715 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768494005716 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 768494005717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494005718 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494005719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494005720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494005721 Lysine efflux permease [General function prediction only]; Region: COG1279 768494005722 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 768494005723 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 768494005724 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 768494005725 active site 768494005726 nucleophile elbow; other site 768494005727 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 768494005728 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 768494005729 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768494005730 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 768494005731 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 768494005732 nudix motif; other site 768494005733 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 768494005734 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 768494005735 homodimer interface [polypeptide binding]; other site 768494005736 NAD binding pocket [chemical binding]; other site 768494005737 ATP binding pocket [chemical binding]; other site 768494005738 Mg binding site [ion binding]; other site 768494005739 active-site loop [active] 768494005740 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768494005741 FtsX-like permease family; Region: FtsX; pfam02687 768494005742 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768494005743 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 768494005744 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 768494005745 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 768494005746 active site 768494005747 catalytic residues [active] 768494005748 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494005749 dimerization interface [polypeptide binding]; other site 768494005750 putative DNA binding site [nucleotide binding]; other site 768494005751 putative Zn2+ binding site [ion binding]; other site 768494005752 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768494005753 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768494005754 active site 768494005755 catalytic tetrad [active] 768494005756 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768494005757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494005758 putative substrate translocation pore; other site 768494005759 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 768494005760 Protein of unknown function (DUF664); Region: DUF664; pfam04978 768494005761 DinB superfamily; Region: DinB_2; pfam12867 768494005762 GTPase RsgA; Reviewed; Region: PRK01889 768494005763 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768494005764 RNA binding site [nucleotide binding]; other site 768494005765 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 768494005766 GTPase/Zn-binding domain interface [polypeptide binding]; other site 768494005767 GTP/Mg2+ binding site [chemical binding]; other site 768494005768 G4 box; other site 768494005769 G5 box; other site 768494005770 G1 box; other site 768494005771 Switch I region; other site 768494005772 G2 box; other site 768494005773 G3 box; other site 768494005774 Switch II region; other site 768494005775 Tar ligand binding domain homologue; Region: TarH; pfam02203 768494005776 Cache domain; Region: Cache_1; pfam02743 768494005777 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 768494005778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494005779 dimerization interface [polypeptide binding]; other site 768494005780 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494005781 dimer interface [polypeptide binding]; other site 768494005782 putative CheW interface [polypeptide binding]; other site 768494005783 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 768494005784 Uncharacterized membrane protein [Function unknown]; Region: COG3949 768494005785 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 768494005786 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 768494005787 dimerization interface [polypeptide binding]; other site 768494005788 DPS ferroxidase diiron center [ion binding]; other site 768494005789 ion pore; other site 768494005790 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 768494005791 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 768494005792 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 768494005793 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 768494005794 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 768494005795 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 768494005796 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768494005797 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494005798 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494005799 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768494005800 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768494005801 active site 768494005802 catalytic tetrad [active] 768494005803 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768494005804 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 768494005805 P-loop, Walker A motif; other site 768494005806 Base recognition motif; other site 768494005807 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 768494005808 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768494005809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494005810 Coenzyme A binding pocket [chemical binding]; other site 768494005811 Replication-relaxation; Region: Replic_Relax; pfam13814 768494005812 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 768494005813 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 768494005814 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 768494005815 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 768494005816 metal binding site [ion binding]; metal-binding site 768494005817 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 768494005818 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768494005819 NAD binding site [chemical binding]; other site 768494005820 active site 768494005821 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 768494005822 homotetramer interface [polypeptide binding]; other site 768494005823 active site 768494005824 substrate binding site [chemical binding]; other site 768494005825 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768494005826 FMN binding site [chemical binding]; other site 768494005827 catalytic residue [active] 768494005828 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 768494005829 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 768494005830 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768494005831 DNA binding site [nucleotide binding] 768494005832 active site 768494005833 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 768494005834 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768494005835 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494005836 peptide binding site [polypeptide binding]; other site 768494005837 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 768494005838 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768494005839 active site 768494005840 metal binding site [ion binding]; metal-binding site 768494005841 short chain dehydrogenase; Provisional; Region: PRK08309 768494005842 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768494005843 catalytic core [active] 768494005844 CotH protein; Region: CotH; pfam08757 768494005845 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 768494005846 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 768494005847 nudix motif; other site 768494005848 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768494005849 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768494005850 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768494005851 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 768494005852 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768494005853 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 768494005854 Cl binding site [ion binding]; other site 768494005855 oligomer interface [polypeptide binding]; other site 768494005856 Predicted permeases [General function prediction only]; Region: COG0701 768494005857 Predicted membrane protein [Function unknown]; Region: COG3689 768494005858 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 768494005859 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 768494005860 PLD-like domain; Region: PLDc_2; pfam13091 768494005861 putative active site [active] 768494005862 catalytic site [active] 768494005863 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 768494005864 PLD-like domain; Region: PLDc_2; pfam13091 768494005865 putative active site [active] 768494005866 catalytic site [active] 768494005867 Coat F domain; Region: Coat_F; pfam07875 768494005868 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 768494005869 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768494005870 NAD binding site [chemical binding]; other site 768494005871 substrate binding site [chemical binding]; other site 768494005872 putative active site [active] 768494005873 Protein of unknown function (DUF456); Region: DUF456; pfam04306 768494005874 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768494005875 Domain of unknown function DUF21; Region: DUF21; pfam01595 768494005876 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768494005877 Transporter associated domain; Region: CorC_HlyC; smart01091 768494005878 FOG: CBS domain [General function prediction only]; Region: COG0517 768494005879 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 768494005880 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 768494005881 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 768494005882 dimer interface [polypeptide binding]; other site 768494005883 putative tRNA-binding site [nucleotide binding]; other site 768494005884 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 768494005885 DinB superfamily; Region: DinB_2; pfam12867 768494005886 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 768494005887 stage II sporulation protein P; Region: spore_II_P; TIGR02867 768494005888 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494005889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494005890 Coenzyme A binding pocket [chemical binding]; other site 768494005891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494005892 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 768494005893 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 768494005894 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 768494005895 nudix motif; other site 768494005896 amidase; Provisional; Region: PRK06828 768494005897 Amidase; Region: Amidase; pfam01425 768494005898 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494005899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494005900 putative substrate translocation pore; other site 768494005901 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 768494005902 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 768494005903 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 768494005904 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768494005905 catalytic core [active] 768494005906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494005907 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768494005908 active site 768494005909 motif I; other site 768494005910 motif II; other site 768494005911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494005912 DinB superfamily; Region: DinB_2; pfam12867 768494005913 DinB family; Region: DinB; cl17821 768494005914 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 768494005915 alanine racemase; Reviewed; Region: alr; PRK00053 768494005916 active site 768494005917 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768494005918 dimer interface [polypeptide binding]; other site 768494005919 substrate binding site [chemical binding]; other site 768494005920 catalytic residues [active] 768494005921 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768494005922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494005923 S-adenosylmethionine binding site [chemical binding]; other site 768494005924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494005925 Coenzyme A binding pocket [chemical binding]; other site 768494005926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494005927 Coenzyme A binding pocket [chemical binding]; other site 768494005928 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768494005929 active site 768494005930 ATP binding site [chemical binding]; other site 768494005931 substrate binding site [chemical binding]; other site 768494005932 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 768494005933 glycosyltransferase, MGT family; Region: MGT; TIGR01426 768494005934 active site 768494005935 TDP-binding site; other site 768494005936 acceptor substrate-binding pocket; other site 768494005937 homodimer interface [polypeptide binding]; other site 768494005938 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768494005939 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494005940 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768494005941 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768494005942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494005943 DNA-binding site [nucleotide binding]; DNA binding site 768494005944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494005945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494005946 homodimer interface [polypeptide binding]; other site 768494005947 catalytic residue [active] 768494005948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494005949 Coenzyme A binding pocket [chemical binding]; other site 768494005950 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768494005951 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 768494005952 active site 768494005953 metal binding site [ion binding]; metal-binding site 768494005954 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 768494005955 Src Homology 3 domain superfamily; Region: SH3; cl17036 768494005956 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 768494005957 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494005958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494005959 Coenzyme A binding pocket [chemical binding]; other site 768494005960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494005961 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768494005962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494005963 Coenzyme A binding pocket [chemical binding]; other site 768494005964 Cupin domain; Region: Cupin_2; cl17218 768494005965 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 768494005966 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 768494005967 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768494005968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494005969 S-adenosylmethionine binding site [chemical binding]; other site 768494005970 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 768494005971 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 768494005972 Potassium binding sites [ion binding]; other site 768494005973 Cesium cation binding sites [ion binding]; other site 768494005974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 768494005975 DEAD-like helicases superfamily; Region: DEXDc; smart00487 768494005976 ATP binding site [chemical binding]; other site 768494005977 putative Mg++ binding site [ion binding]; other site 768494005978 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494005979 nucleotide binding region [chemical binding]; other site 768494005980 ATP-binding site [chemical binding]; other site 768494005981 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768494005982 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494005983 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 768494005984 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768494005985 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 768494005986 NADP binding site [chemical binding]; other site 768494005987 dimer interface [polypeptide binding]; other site 768494005988 RNA polymerase sigma factor; Provisional; Region: PRK12543 768494005989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494005990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494005991 DNA binding residues [nucleotide binding] 768494005992 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 768494005993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494005994 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 768494005995 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 768494005996 catalytic residues [active] 768494005997 dimer interface [polypeptide binding]; other site 768494005998 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768494005999 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768494006000 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 768494006001 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 768494006002 Protein of unknown function DUF58; Region: DUF58; pfam01882 768494006003 MoxR-like ATPases [General function prediction only]; Region: COG0714 768494006004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494006005 Walker A motif; other site 768494006006 ATP binding site [chemical binding]; other site 768494006007 Walker B motif; other site 768494006008 arginine finger; other site 768494006009 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 768494006010 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 768494006011 [4Fe-4S] binding site [ion binding]; other site 768494006012 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768494006013 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768494006014 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768494006015 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 768494006016 molybdopterin cofactor binding site; other site 768494006017 nitrate reductase, beta subunit; Region: narH; TIGR01660 768494006018 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 768494006019 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 768494006020 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 768494006021 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 768494006022 Predicted transcriptional regulators [Transcription]; Region: COG1725 768494006023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494006024 DNA-binding site [nucleotide binding]; DNA binding site 768494006025 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494006026 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494006027 Walker A/P-loop; other site 768494006028 ATP binding site [chemical binding]; other site 768494006029 Q-loop/lid; other site 768494006030 ABC transporter signature motif; other site 768494006031 Walker B; other site 768494006032 D-loop; other site 768494006033 H-loop/switch region; other site 768494006034 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 768494006035 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768494006036 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768494006037 ligand binding site [chemical binding]; other site 768494006038 flexible hinge region; other site 768494006039 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768494006040 putative switch regulator; other site 768494006041 non-specific DNA interactions [nucleotide binding]; other site 768494006042 DNA binding site [nucleotide binding] 768494006043 sequence specific DNA binding site [nucleotide binding]; other site 768494006044 putative cAMP binding site [chemical binding]; other site 768494006045 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 768494006046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494006047 FeS/SAM binding site; other site 768494006048 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768494006049 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 768494006050 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768494006051 ATP binding site [chemical binding]; other site 768494006052 substrate interface [chemical binding]; other site 768494006053 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 768494006054 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 768494006055 dimer interface [polypeptide binding]; other site 768494006056 putative functional site; other site 768494006057 putative MPT binding site; other site 768494006058 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 768494006059 MoaE homodimer interface [polypeptide binding]; other site 768494006060 MoaD interaction [polypeptide binding]; other site 768494006061 active site residues [active] 768494006062 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 768494006063 MoaE interaction surface [polypeptide binding]; other site 768494006064 MoeB interaction surface [polypeptide binding]; other site 768494006065 thiocarboxylated glycine; other site 768494006066 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 768494006067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494006068 putative substrate translocation pore; other site 768494006069 Predicted permeases [General function prediction only]; Region: COG0679 768494006070 precorrin-2 dehydrogenase; Validated; Region: PRK06719 768494006071 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 768494006072 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 768494006073 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 768494006074 putative active site [active] 768494006075 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 768494006076 putative active site [active] 768494006077 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 768494006078 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768494006079 active site 768494006080 SAM binding site [chemical binding]; other site 768494006081 homodimer interface [polypeptide binding]; other site 768494006082 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 768494006083 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 768494006084 [2Fe-2S] cluster binding site [ion binding]; other site 768494006085 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 768494006086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768494006087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494006088 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768494006089 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768494006090 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768494006091 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 768494006092 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 768494006093 Hemerythrin-like domain; Region: Hr-like; cd12108 768494006094 Fe binding site [ion binding]; other site 768494006095 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 768494006096 N-acetyltransferase; Region: Acetyltransf_2; cl00949 768494006097 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 768494006098 PGAP1-like protein; Region: PGAP1; pfam07819 768494006099 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 768494006100 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 768494006101 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768494006102 Zn2+ binding site [ion binding]; other site 768494006103 Mg2+ binding site [ion binding]; other site 768494006104 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 768494006105 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768494006106 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494006107 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494006108 ABC transporter; Region: ABC_tran_2; pfam12848 768494006109 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494006110 Bax inhibitor 1 like; Region: BaxI_1; cl17691 768494006111 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 768494006112 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 768494006113 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768494006114 dimer interface [polypeptide binding]; other site 768494006115 ssDNA binding site [nucleotide binding]; other site 768494006116 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768494006117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494006118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494006119 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768494006120 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768494006121 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 768494006122 Virulence factor; Region: Virulence_fact; pfam13769 768494006123 HEAT repeats; Region: HEAT_2; pfam13646 768494006124 HEAT repeats; Region: HEAT_2; pfam13646 768494006125 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 768494006126 Protein of unknown function, DUF393; Region: DUF393; pfam04134 768494006127 Disulphide isomerase; Region: Disulph_isomer; pfam06491 768494006128 Brix domain; Region: Brix; cl00935 768494006129 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 768494006130 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 768494006131 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 768494006132 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 768494006133 active site 768494006134 HIGH motif; other site 768494006135 KMSK motif region; other site 768494006136 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 768494006137 tRNA binding surface [nucleotide binding]; other site 768494006138 anticodon binding site; other site 768494006139 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 768494006140 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768494006141 Methyltransferase domain; Region: Methyltransf_12; pfam08242 768494006142 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 768494006143 putative active site [active] 768494006144 TPR repeat; Region: TPR_11; pfam13414 768494006145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494006146 TPR motif; other site 768494006147 binding surface 768494006148 TPR repeat; Region: TPR_11; pfam13414 768494006149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494006150 binding surface 768494006151 TPR motif; other site 768494006152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494006153 binding surface 768494006154 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768494006155 TPR motif; other site 768494006156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494006157 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768494006158 binding surface 768494006159 TPR motif; other site 768494006160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494006161 binding surface 768494006162 TPR motif; other site 768494006163 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 768494006164 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 768494006165 HIGH motif; other site 768494006166 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 768494006167 active site 768494006168 KMSKS motif; other site 768494006169 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 768494006170 tRNA binding surface [nucleotide binding]; other site 768494006171 anticodon binding site; other site 768494006172 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 768494006173 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 768494006174 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 768494006175 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 768494006176 Zn binding site [ion binding]; other site 768494006177 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768494006178 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 768494006179 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768494006180 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 768494006181 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 768494006182 Dimer interface [polypeptide binding]; other site 768494006183 anticodon binding site; other site 768494006184 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 768494006185 homodimer interface [polypeptide binding]; other site 768494006186 motif 1; other site 768494006187 motif 2; other site 768494006188 active site 768494006189 motif 3; other site 768494006190 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 768494006191 metal ion-dependent adhesion site (MIDAS); other site 768494006192 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 768494006193 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 768494006194 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768494006195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494006196 Walker A motif; other site 768494006197 ATP binding site [chemical binding]; other site 768494006198 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768494006199 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 768494006200 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768494006201 active site 768494006202 ATP binding site [chemical binding]; other site 768494006203 substrate binding site [chemical binding]; other site 768494006204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494006205 binding surface 768494006206 TPR motif; other site 768494006207 TPR repeat; Region: TPR_11; pfam13414 768494006208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494006209 binding surface 768494006210 TPR motif; other site 768494006211 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494006212 binding surface 768494006213 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768494006214 TPR motif; other site 768494006215 SseB protein; Region: SseB; cl06279 768494006216 Proteins of 100 residues with WXG; Region: WXG100; cl02005 768494006217 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 768494006218 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 768494006219 Immunity protein Imm3; Region: Imm3; pfam14425 768494006220 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 768494006221 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 768494006222 catalytic residues [active] 768494006223 catalytic nucleophile [active] 768494006224 Recombinase; Region: Recombinase; pfam07508 768494006225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 768494006226 Transposase; Region: DEDD_Tnp_IS110; pfam01548 768494006227 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 768494006228 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 768494006229 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 768494006230 glycerate kinase; Region: TIGR00045 768494006231 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768494006232 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 768494006233 transmembrane helices; other site 768494006234 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494006235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494006236 active site 768494006237 phosphorylation site [posttranslational modification] 768494006238 intermolecular recognition site; other site 768494006239 dimerization interface [polypeptide binding]; other site 768494006240 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494006241 DNA binding site [nucleotide binding] 768494006242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494006243 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494006244 dimerization interface [polypeptide binding]; other site 768494006245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494006246 dimer interface [polypeptide binding]; other site 768494006247 phosphorylation site [posttranslational modification] 768494006248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494006249 ATP binding site [chemical binding]; other site 768494006250 Mg2+ binding site [ion binding]; other site 768494006251 G-X-G motif; other site 768494006252 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 768494006253 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 768494006254 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 768494006255 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 768494006256 Na2 binding site [ion binding]; other site 768494006257 putative substrate binding site 1 [chemical binding]; other site 768494006258 Na binding site 1 [ion binding]; other site 768494006259 putative substrate binding site 2 [chemical binding]; other site 768494006260 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768494006261 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 768494006262 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 768494006263 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 768494006264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494006265 motif II; other site 768494006266 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 768494006267 fructuronate transporter; Provisional; Region: PRK10034; cl15264 768494006268 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 768494006269 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 768494006270 active site 768494006271 NAD binding site [chemical binding]; other site 768494006272 metal binding site [ion binding]; metal-binding site 768494006273 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 768494006274 aspartate racemase; Region: asp_race; TIGR00035 768494006275 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 768494006276 homodimer interaction site [polypeptide binding]; other site 768494006277 cofactor binding site; other site 768494006278 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768494006279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494006280 Coenzyme A binding pocket [chemical binding]; other site 768494006281 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 768494006282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494006283 active site 768494006284 motif I; other site 768494006285 motif II; other site 768494006286 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768494006287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494006288 Coenzyme A binding pocket [chemical binding]; other site 768494006289 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 768494006290 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494006291 Walker A/P-loop; other site 768494006292 ATP binding site [chemical binding]; other site 768494006293 Q-loop/lid; other site 768494006294 ABC transporter signature motif; other site 768494006295 Walker B; other site 768494006296 D-loop; other site 768494006297 H-loop/switch region; other site 768494006298 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 768494006299 YpjP-like protein; Region: YpjP; pfam14005 768494006300 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 768494006301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494006302 motif II; other site 768494006303 hypothetical protein; Provisional; Region: PRK06724 768494006304 active site 768494006305 Phosphotransferase enzyme family; Region: APH; pfam01636 768494006306 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 768494006307 active site 768494006308 ATP binding site [chemical binding]; other site 768494006309 substrate binding site [chemical binding]; other site 768494006310 Peptidase family S41; Region: Peptidase_S41; pfam03572 768494006311 Active site serine [active] 768494006312 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494006313 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494006314 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 768494006315 thymidylate synthase; Region: thym_sym; TIGR03284 768494006316 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 768494006317 dimerization interface [polypeptide binding]; other site 768494006318 active site 768494006319 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 768494006320 folate binding site [chemical binding]; other site 768494006321 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 768494006322 NADP+ binding site [chemical binding]; other site 768494006323 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 768494006324 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768494006325 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 768494006326 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494006327 azoreductase; Reviewed; Region: PRK00170 768494006328 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768494006329 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768494006330 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768494006331 putative acyl-acceptor binding pocket; other site 768494006332 Haemolysin-III related; Region: HlyIII; cl03831 768494006333 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 768494006334 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 768494006335 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 768494006336 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 768494006337 EDD domain protein, DegV family; Region: DegV; TIGR00762 768494006338 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 768494006339 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 768494006340 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 768494006341 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 768494006342 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 768494006343 Cu(I) binding site [ion binding]; other site 768494006344 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768494006345 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 768494006346 putative dimer interface [polypeptide binding]; other site 768494006347 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 768494006348 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 768494006349 active site 768494006350 dimer interface [polypeptide binding]; other site 768494006351 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 768494006352 Ligand Binding Site [chemical binding]; other site 768494006353 Molecular Tunnel; other site 768494006354 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494006355 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768494006356 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768494006357 siderophore binding site; other site 768494006358 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768494006359 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 768494006360 homodimer interface [polypeptide binding]; other site 768494006361 substrate-cofactor binding pocket; other site 768494006362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494006363 catalytic residue [active] 768494006364 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 768494006365 FMN binding site [chemical binding]; other site 768494006366 dimer interface [polypeptide binding]; other site 768494006367 Isochorismatase family; Region: Isochorismatase; pfam00857 768494006368 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768494006369 catalytic triad [active] 768494006370 conserved cis-peptide bond; other site 768494006371 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 768494006372 nudix motif; other site 768494006373 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768494006374 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 768494006375 putative dimer interface [polypeptide binding]; other site 768494006376 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 768494006377 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768494006378 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 768494006379 GAF domain; Region: GAF; pfam01590 768494006380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 768494006381 Histidine kinase; Region: HisKA_3; pfam07730 768494006382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494006383 ATP binding site [chemical binding]; other site 768494006384 Mg2+ binding site [ion binding]; other site 768494006385 G-X-G motif; other site 768494006386 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768494006387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494006388 active site 768494006389 phosphorylation site [posttranslational modification] 768494006390 intermolecular recognition site; other site 768494006391 dimerization interface [polypeptide binding]; other site 768494006392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768494006393 DNA binding residues [nucleotide binding] 768494006394 dimerization interface [polypeptide binding]; other site 768494006395 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 768494006396 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768494006397 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768494006398 putative active site [active] 768494006399 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 768494006400 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 768494006401 NAD binding site [chemical binding]; other site 768494006402 substrate binding site [chemical binding]; other site 768494006403 catalytic Zn binding site [ion binding]; other site 768494006404 tetramer interface [polypeptide binding]; other site 768494006405 structural Zn binding site [ion binding]; other site 768494006406 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768494006407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494006408 dimer interface [polypeptide binding]; other site 768494006409 conserved gate region; other site 768494006410 ABC-ATPase subunit interface; other site 768494006411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768494006412 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768494006413 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494006414 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494006415 Beta-lactamase; Region: Beta-lactamase; cl17358 768494006416 Erythromycin esterase; Region: Erythro_esteras; pfam05139 768494006417 Erythromycin esterase; Region: Erythro_esteras; cl17110 768494006418 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768494006419 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768494006420 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768494006421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494006422 active site 768494006423 Predicted flavoprotein [General function prediction only]; Region: COG0431 768494006424 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768494006425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494006426 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494006427 putative substrate translocation pore; other site 768494006428 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768494006429 Uncharacterized conserved protein [Function unknown]; Region: COG1434 768494006430 putative active site [active] 768494006431 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 768494006432 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 768494006433 Walker A/P-loop; other site 768494006434 ATP binding site [chemical binding]; other site 768494006435 Q-loop/lid; other site 768494006436 ABC transporter signature motif; other site 768494006437 Walker B; other site 768494006438 D-loop; other site 768494006439 H-loop/switch region; other site 768494006440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494006441 dimer interface [polypeptide binding]; other site 768494006442 conserved gate region; other site 768494006443 ABC-ATPase subunit interface; other site 768494006444 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768494006445 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 768494006446 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 768494006447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 768494006448 Protein of unknown function (DUF524); Region: DUF524; pfam04411 768494006449 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 768494006450 Helix-turn-helix domain; Region: HTH_17; cl17695 768494006451 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768494006452 Domain of unknown function DUF21; Region: DUF21; pfam01595 768494006453 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768494006454 Transporter associated domain; Region: CorC_HlyC; smart01091 768494006455 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 768494006456 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768494006457 NAD(P) binding site [chemical binding]; other site 768494006458 catalytic residues [active] 768494006459 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 768494006460 Histidine kinase N terminal; Region: HisK_N; pfam09385 768494006461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494006462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494006463 dimer interface [polypeptide binding]; other site 768494006464 phosphorylation site [posttranslational modification] 768494006465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494006466 ATP binding site [chemical binding]; other site 768494006467 Mg2+ binding site [ion binding]; other site 768494006468 G-X-G motif; other site 768494006469 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 768494006470 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 768494006471 hypothetical protein; Provisional; Region: PRK06917 768494006472 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768494006473 inhibitor-cofactor binding pocket; inhibition site 768494006474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494006475 catalytic residue [active] 768494006476 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 768494006477 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 768494006478 acetylornithine deacetylase; Validated; Region: PRK06915 768494006479 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 768494006480 metal binding site [ion binding]; metal-binding site 768494006481 dimer interface [polypeptide binding]; other site 768494006482 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 768494006483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494006484 PAS fold; Region: PAS_4; pfam08448 768494006485 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 768494006486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494006487 Walker A motif; other site 768494006488 ATP binding site [chemical binding]; other site 768494006489 Walker B motif; other site 768494006490 arginine finger; other site 768494006491 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768494006492 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 768494006493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494006494 FeS/SAM binding site; other site 768494006495 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 768494006496 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 768494006497 toxin interface [polypeptide binding]; other site 768494006498 Zn binding site [ion binding]; other site 768494006499 hypothetical protein; Provisional; Region: PRK13672 768494006500 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 768494006501 YozD-like protein; Region: YozD; pfam14162 768494006502 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 768494006503 Catalytic domain of Protein Kinases; Region: PKc; cd00180 768494006504 active site 768494006505 ATP binding site [chemical binding]; other site 768494006506 substrate binding site [chemical binding]; other site 768494006507 activation loop (A-loop); other site 768494006508 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 768494006509 SpoOM protein; Region: Spo0M; pfam07070 768494006510 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768494006511 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 768494006512 active site 768494006513 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768494006514 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 768494006515 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768494006516 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768494006517 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 768494006518 DNA binding site [nucleotide binding] 768494006519 active site 768494006520 Int/Topo IB signature motif; other site 768494006521 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 768494006522 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 768494006523 S-layer homology domain; Region: SLH; pfam00395 768494006524 S-layer homology domain; Region: SLH; pfam00395 768494006525 S-layer homology domain; Region: SLH; pfam00395 768494006526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494006527 sequence-specific DNA binding site [nucleotide binding]; other site 768494006528 salt bridge; other site 768494006529 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768494006530 Replication-relaxation; Region: Replic_Relax; pfam13814 768494006531 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768494006532 homotrimer interaction site [polypeptide binding]; other site 768494006533 putative active site [active] 768494006534 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 768494006535 CHRD domain; Region: CHRD; pfam07452 768494006536 C1q domain; Region: C1q; cl17543 768494006537 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 768494006538 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768494006539 YolD-like protein; Region: YolD; pfam08863 768494006540 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 768494006541 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 768494006542 Transglycosylase; Region: Transgly; pfam00912 768494006543 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 768494006544 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494006545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494006546 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494006547 putative substrate translocation pore; other site 768494006548 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 768494006549 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 768494006550 dimer interface [polypeptide binding]; other site 768494006551 Citrate synthase; Region: Citrate_synt; pfam00285 768494006552 active site 768494006553 coenzyme A binding site [chemical binding]; other site 768494006554 citrylCoA binding site [chemical binding]; other site 768494006555 oxalacetate/citrate binding site [chemical binding]; other site 768494006556 catalytic triad [active] 768494006557 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 768494006558 2-methylcitrate dehydratase; Region: prpD; TIGR02330 768494006559 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 768494006560 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 768494006561 tetramer interface [polypeptide binding]; other site 768494006562 active site 768494006563 Mg2+/Mn2+ binding site [ion binding]; other site 768494006564 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768494006565 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768494006566 active site 768494006567 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 768494006568 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768494006569 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 768494006570 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 768494006571 tetrameric interface [polypeptide binding]; other site 768494006572 NAD binding site [chemical binding]; other site 768494006573 catalytic residues [active] 768494006574 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768494006575 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 768494006576 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768494006577 substrate binding site [chemical binding]; other site 768494006578 oxyanion hole (OAH) forming residues; other site 768494006579 trimer interface [polypeptide binding]; other site 768494006580 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 768494006581 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 768494006582 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 768494006583 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 768494006584 active site 768494006585 metal binding site [ion binding]; metal-binding site 768494006586 DNA binding site [nucleotide binding] 768494006587 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 768494006588 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 768494006589 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 768494006590 Walker A/P-loop; other site 768494006591 ATP binding site [chemical binding]; other site 768494006592 Q-loop/lid; other site 768494006593 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 768494006594 ABC transporter signature motif; other site 768494006595 Walker B; other site 768494006596 D-loop; other site 768494006597 H-loop/switch region; other site 768494006598 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494006599 dimerization interface [polypeptide binding]; other site 768494006600 putative DNA binding site [nucleotide binding]; other site 768494006601 putative Zn2+ binding site [ion binding]; other site 768494006602 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 768494006603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494006604 putative substrate translocation pore; other site 768494006605 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 768494006606 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 768494006607 putative NAD(P) binding site [chemical binding]; other site 768494006608 active site 768494006609 isochorismate synthase DhbC; Validated; Region: PRK06923 768494006610 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 768494006611 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 768494006612 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 768494006613 acyl-activating enzyme (AAE) consensus motif; other site 768494006614 active site 768494006615 AMP binding site [chemical binding]; other site 768494006616 substrate binding site [chemical binding]; other site 768494006617 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 768494006618 hydrophobic substrate binding pocket; other site 768494006619 Isochorismatase family; Region: Isochorismatase; pfam00857 768494006620 active site 768494006621 conserved cis-peptide bond; other site 768494006622 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 768494006623 Condensation domain; Region: Condensation; pfam00668 768494006624 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768494006625 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768494006626 acyl-activating enzyme (AAE) consensus motif; other site 768494006627 AMP binding site [chemical binding]; other site 768494006628 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768494006629 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 768494006630 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768494006631 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768494006632 acyl-activating enzyme (AAE) consensus motif; other site 768494006633 AMP binding site [chemical binding]; other site 768494006634 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768494006635 MbtH-like protein; Region: MbtH; cl01279 768494006636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494006637 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494006638 putative substrate translocation pore; other site 768494006639 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 768494006640 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 768494006641 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768494006642 IHF dimer interface [polypeptide binding]; other site 768494006643 IHF - DNA interface [nucleotide binding]; other site 768494006644 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 768494006645 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 768494006646 DinB family; Region: DinB; cl17821 768494006647 DinB superfamily; Region: DinB_2; pfam12867 768494006648 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 768494006649 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 768494006650 active site 768494006651 catalytic triad [active] 768494006652 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768494006653 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 768494006654 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 768494006655 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 768494006656 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768494006657 RNA binding surface [nucleotide binding]; other site 768494006658 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 768494006659 probable active site [active] 768494006660 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 768494006661 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 768494006662 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768494006663 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 768494006664 active site 768494006665 dimer interface [polypeptide binding]; other site 768494006666 motif 1; other site 768494006667 motif 2; other site 768494006668 motif 3; other site 768494006669 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 768494006670 anticodon binding site; other site 768494006671 potential frameshift: common BLAST hit: gi|301053906|ref|YP_003792117.1| ABC transporter ATP-binding protein 768494006672 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768494006673 Walker A/P-loop; other site 768494006674 ATP binding site [chemical binding]; other site 768494006675 ABC transporter; Region: ABC_tran; pfam00005 768494006676 Q-loop/lid; other site 768494006677 ABC transporter signature motif; other site 768494006678 Walker B; other site 768494006679 D-loop; other site 768494006680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494006681 H-loop/switch region; other site 768494006682 FtsX-like permease family; Region: FtsX; pfam02687 768494006683 Protein of unknown function (DUF867); Region: DUF867; cl01713 768494006684 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768494006685 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768494006686 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 768494006687 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494006688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494006689 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768494006690 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768494006691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494006692 dimer interface [polypeptide binding]; other site 768494006693 conserved gate region; other site 768494006694 ABC-ATPase subunit interface; other site 768494006695 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 768494006696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494006697 S-adenosylmethionine binding site [chemical binding]; other site 768494006698 Protein of unknown function (DUF2185); Region: DUF2185; pfam09951 768494006699 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494006700 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 768494006701 active site 768494006702 dimerization interface [polypeptide binding]; other site 768494006703 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 768494006704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 768494006705 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494006706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494006707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494006708 MMPL family; Region: MMPL; pfam03176 768494006709 MMPL family; Region: MMPL; pfam03176 768494006710 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 768494006711 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 768494006712 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 768494006713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494006714 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768494006715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494006716 Coenzyme A binding pocket [chemical binding]; other site 768494006717 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768494006718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494006719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494006720 Coenzyme A binding pocket [chemical binding]; other site 768494006721 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 768494006722 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 768494006723 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 768494006724 putative acetyltransferase YhhY; Provisional; Region: PRK10140 768494006725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494006726 Coenzyme A binding pocket [chemical binding]; other site 768494006727 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768494006728 EamA-like transporter family; Region: EamA; pfam00892 768494006729 EamA-like transporter family; Region: EamA; pfam00892 768494006730 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768494006731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494006732 non-specific DNA binding site [nucleotide binding]; other site 768494006733 salt bridge; other site 768494006734 sequence-specific DNA binding site [nucleotide binding]; other site 768494006735 Cupin domain; Region: Cupin_2; pfam07883 768494006736 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 768494006737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768494006738 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768494006739 protoporphyrinogen oxidase; Provisional; Region: PRK12416 768494006740 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768494006741 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494006742 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494006743 Cold-inducible protein YdjO; Region: YdjO; pfam14169 768494006744 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768494006745 DNA-binding site [nucleotide binding]; DNA binding site 768494006746 RNA-binding motif; other site 768494006747 CAAX protease self-immunity; Region: Abi; pfam02517 768494006748 AAA domain; Region: AAA_17; pfam13207 768494006749 AAA domain; Region: AAA_18; pfam13238 768494006750 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 768494006751 active site 768494006752 metal binding site [ion binding]; metal-binding site 768494006753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494006754 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768494006755 active site 768494006756 motif I; other site 768494006757 motif II; other site 768494006758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494006759 motif II; other site 768494006760 hypothetical protein; Provisional; Region: PRK06770 768494006761 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 768494006762 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 768494006763 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768494006764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494006765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768494006766 dimerization interface [polypeptide binding]; other site 768494006767 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 768494006768 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768494006769 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768494006770 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 768494006771 active site 768494006772 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 768494006773 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 768494006774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494006775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768494006776 dimerization interface [polypeptide binding]; other site 768494006777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 768494006778 MOSC domain; Region: MOSC; pfam03473 768494006779 3-alpha domain; Region: 3-alpha; pfam03475 768494006780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494006781 Coenzyme A binding pocket [chemical binding]; other site 768494006782 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 768494006783 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768494006784 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494006785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494006786 Walker A/P-loop; other site 768494006787 ATP binding site [chemical binding]; other site 768494006788 Q-loop/lid; other site 768494006789 ABC transporter signature motif; other site 768494006790 Walker B; other site 768494006791 D-loop; other site 768494006792 H-loop/switch region; other site 768494006793 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768494006794 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494006795 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 768494006796 Walker A/P-loop; other site 768494006797 ATP binding site [chemical binding]; other site 768494006798 Q-loop/lid; other site 768494006799 ABC transporter signature motif; other site 768494006800 Walker B; other site 768494006801 D-loop; other site 768494006802 H-loop/switch region; other site 768494006803 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768494006804 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 768494006805 active site 768494006806 metal binding site [ion binding]; metal-binding site 768494006807 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 768494006808 LysE type translocator; Region: LysE; cl00565 768494006809 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768494006810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494006811 non-specific DNA binding site [nucleotide binding]; other site 768494006812 salt bridge; other site 768494006813 sequence-specific DNA binding site [nucleotide binding]; other site 768494006814 Cupin domain; Region: Cupin_2; pfam07883 768494006815 BclB C-terminal domain; Region: exospore_TM; TIGR03721 768494006816 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 768494006817 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768494006818 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 768494006819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494006820 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 768494006821 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768494006822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494006823 S-adenosylmethionine binding site [chemical binding]; other site 768494006824 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 768494006825 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 768494006826 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 768494006827 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768494006828 active site 768494006829 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768494006830 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768494006831 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 768494006832 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768494006833 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768494006834 nucleotide binding site [chemical binding]; other site 768494006835 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 768494006836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 768494006837 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 768494006838 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768494006839 catalytic residue [active] 768494006840 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 768494006841 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768494006842 tetramer interface [polypeptide binding]; other site 768494006843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494006844 catalytic residue [active] 768494006845 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768494006846 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 768494006847 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768494006848 ATP binding site [chemical binding]; other site 768494006849 Mg++ binding site [ion binding]; other site 768494006850 motif III; other site 768494006851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494006852 nucleotide binding region [chemical binding]; other site 768494006853 ATP-binding site [chemical binding]; other site 768494006854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494006855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494006856 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494006857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 768494006858 FtsX-like permease family; Region: FtsX; pfam02687 768494006859 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768494006860 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768494006861 Walker A/P-loop; other site 768494006862 ATP binding site [chemical binding]; other site 768494006863 Q-loop/lid; other site 768494006864 ABC transporter signature motif; other site 768494006865 Walker B; other site 768494006866 D-loop; other site 768494006867 H-loop/switch region; other site 768494006868 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768494006869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494006870 S-adenosylmethionine binding site [chemical binding]; other site 768494006871 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768494006872 dimer interface [polypeptide binding]; other site 768494006873 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768494006874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494006875 S-adenosylmethionine binding site [chemical binding]; other site 768494006876 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 768494006877 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 768494006878 dimer interface [polypeptide binding]; other site 768494006879 PYR/PP interface [polypeptide binding]; other site 768494006880 TPP binding site [chemical binding]; other site 768494006881 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768494006882 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 768494006883 TPP-binding site [chemical binding]; other site 768494006884 dimer interface [polypeptide binding]; other site 768494006885 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494006886 MarR family; Region: MarR_2; pfam12802 768494006887 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768494006888 catalytic core [active] 768494006889 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 768494006890 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 768494006891 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 768494006892 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 768494006893 metal binding site [ion binding]; metal-binding site 768494006894 dimer interface [polypeptide binding]; other site 768494006895 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 768494006896 active site 768494006897 catalytic triad [active] 768494006898 oxyanion hole [active] 768494006899 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 768494006900 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494006901 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494006902 DNA binding residues [nucleotide binding] 768494006903 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 768494006904 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768494006905 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494006906 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768494006907 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 768494006908 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768494006909 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494006910 beta-lactamase TEM; Provisional; Region: PRK15442 768494006911 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 768494006912 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 768494006913 active site 768494006914 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768494006915 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768494006916 DNA binding site [nucleotide binding] 768494006917 domain linker motif; other site 768494006918 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768494006919 ligand binding site [chemical binding]; other site 768494006920 dimerization interface [polypeptide binding]; other site 768494006921 polyol permease family; Region: 2A0118; TIGR00897 768494006922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494006923 putative substrate translocation pore; other site 768494006924 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768494006925 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768494006926 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768494006927 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768494006928 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768494006929 substrate binding site [chemical binding]; other site 768494006930 ATP binding site [chemical binding]; other site 768494006931 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 768494006932 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 768494006933 tetrameric interface [polypeptide binding]; other site 768494006934 NAD binding site [chemical binding]; other site 768494006935 catalytic residues [active] 768494006936 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 768494006937 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768494006938 PYR/PP interface [polypeptide binding]; other site 768494006939 dimer interface [polypeptide binding]; other site 768494006940 TPP binding site [chemical binding]; other site 768494006941 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768494006942 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 768494006943 TPP-binding site; other site 768494006944 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768494006945 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768494006946 intersubunit interface [polypeptide binding]; other site 768494006947 active site 768494006948 zinc binding site [ion binding]; other site 768494006949 Na+ binding site [ion binding]; other site 768494006950 KduI/IolB family; Region: KduI; pfam04962 768494006951 DinB superfamily; Region: DinB_2; pfam12867 768494006952 DinB superfamily; Region: DinB_2; pfam12867 768494006953 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 768494006954 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768494006955 active site 768494006956 metal binding site [ion binding]; metal-binding site 768494006957 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768494006958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494006959 TPR motif; other site 768494006960 binding surface 768494006961 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494006962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494006963 salt bridge; other site 768494006964 non-specific DNA binding site [nucleotide binding]; other site 768494006965 sequence-specific DNA binding site [nucleotide binding]; other site 768494006966 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 768494006967 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 768494006968 S-layer homology domain; Region: SLH; pfam00395 768494006969 S-layer homology domain; Region: SLH; pfam00395 768494006970 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 768494006971 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768494006972 active site 768494006973 metal binding site [ion binding]; metal-binding site 768494006974 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 768494006975 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 768494006976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494006977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494006978 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768494006979 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494006980 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494006981 PAS fold; Region: PAS_4; pfam08448 768494006982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494006983 putative active site [active] 768494006984 heme pocket [chemical binding]; other site 768494006985 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768494006986 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768494006987 metal binding site [ion binding]; metal-binding site 768494006988 active site 768494006989 I-site; other site 768494006990 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768494006991 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494006992 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494006993 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 768494006994 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 768494006995 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 768494006996 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768494006997 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768494006998 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768494006999 active site residue [active] 768494007000 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768494007001 active site residue [active] 768494007002 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 768494007003 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 768494007004 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494007005 Walker A/P-loop; other site 768494007006 ATP binding site [chemical binding]; other site 768494007007 Q-loop/lid; other site 768494007008 ABC transporter signature motif; other site 768494007009 Walker B; other site 768494007010 D-loop; other site 768494007011 H-loop/switch region; other site 768494007012 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768494007013 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768494007014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494007015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494007016 Protein of unknown function (DUF523); Region: DUF523; pfam04463 768494007017 Uncharacterized conserved protein [Function unknown]; Region: COG3272 768494007018 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 768494007019 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768494007020 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 768494007021 FAD binding site [chemical binding]; other site 768494007022 homotetramer interface [polypeptide binding]; other site 768494007023 substrate binding pocket [chemical binding]; other site 768494007024 catalytic base [active] 768494007025 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 768494007026 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768494007027 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768494007028 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768494007029 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768494007030 carboxyltransferase (CT) interaction site; other site 768494007031 biotinylation site [posttranslational modification]; other site 768494007032 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 768494007033 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 768494007034 active site 768494007035 catalytic residues [active] 768494007036 metal binding site [ion binding]; metal-binding site 768494007037 enoyl-CoA hydratase; Provisional; Region: PRK07657 768494007038 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768494007039 substrate binding site [chemical binding]; other site 768494007040 oxyanion hole (OAH) forming residues; other site 768494007041 trimer interface [polypeptide binding]; other site 768494007042 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 768494007043 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 768494007044 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 768494007045 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 768494007046 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 768494007047 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 768494007048 acyl-activating enzyme (AAE) consensus motif; other site 768494007049 putative AMP binding site [chemical binding]; other site 768494007050 putative active site [active] 768494007051 putative CoA binding site [chemical binding]; other site 768494007052 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494007053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007054 Coenzyme A binding pocket [chemical binding]; other site 768494007055 hypothetical protein; Provisional; Region: PRK08233 768494007056 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 768494007057 active site 768494007058 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768494007059 DinB family; Region: DinB; cl17821 768494007060 DinB superfamily; Region: DinB_2; pfam12867 768494007061 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 768494007062 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768494007063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494007064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494007065 dimer interface [polypeptide binding]; other site 768494007066 phosphorylation site [posttranslational modification] 768494007067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494007068 ATP binding site [chemical binding]; other site 768494007069 Mg2+ binding site [ion binding]; other site 768494007070 G-X-G motif; other site 768494007071 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494007072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494007073 active site 768494007074 phosphorylation site [posttranslational modification] 768494007075 intermolecular recognition site; other site 768494007076 dimerization interface [polypeptide binding]; other site 768494007077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494007078 DNA binding site [nucleotide binding] 768494007079 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768494007080 Zn2+ binding site [ion binding]; other site 768494007081 Mg2+ binding site [ion binding]; other site 768494007082 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 768494007083 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 768494007084 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 768494007085 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768494007086 NAD binding site [chemical binding]; other site 768494007087 substrate binding site [chemical binding]; other site 768494007088 putative active site [active] 768494007089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007090 Coenzyme A binding pocket [chemical binding]; other site 768494007091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007092 Coenzyme A binding pocket [chemical binding]; other site 768494007093 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 768494007094 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 768494007095 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 768494007096 active site 768494007097 Zn binding site [ion binding]; other site 768494007098 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 768494007099 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 768494007100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 768494007101 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 768494007102 putative hydrophobic ligand binding site [chemical binding]; other site 768494007103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494007104 AAA domain; Region: AAA_21; pfam13304 768494007105 Walker A/P-loop; other site 768494007106 ATP binding site [chemical binding]; other site 768494007107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494007108 ABC transporter signature motif; other site 768494007109 Walker B; other site 768494007110 D-loop; other site 768494007111 H-loop/switch region; other site 768494007112 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 768494007113 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 768494007114 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 768494007115 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494007116 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768494007117 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494007118 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494007119 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 768494007120 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 768494007121 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 768494007122 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494007123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494007124 putative substrate translocation pore; other site 768494007125 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 768494007126 nudix motif; other site 768494007127 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 768494007128 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768494007129 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 768494007130 Phosphotransferase enzyme family; Region: APH; pfam01636 768494007131 active site 768494007132 substrate binding site [chemical binding]; other site 768494007133 ATP binding site [chemical binding]; other site 768494007134 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 768494007135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494007136 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 768494007137 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 768494007138 active site 768494007139 Zn binding site [ion binding]; other site 768494007140 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 768494007141 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768494007142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494007143 DNA-binding site [nucleotide binding]; DNA binding site 768494007144 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494007145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494007146 homodimer interface [polypeptide binding]; other site 768494007147 catalytic residue [active] 768494007148 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768494007149 Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240 768494007150 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 768494007151 putative NAD(P) binding site [chemical binding]; other site 768494007152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494007153 S-adenosylmethionine binding site [chemical binding]; other site 768494007154 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768494007155 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 768494007156 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768494007157 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768494007158 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768494007159 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768494007160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494007161 S-adenosylmethionine binding site [chemical binding]; other site 768494007162 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 768494007163 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 768494007164 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494007165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494007166 active site 768494007167 phosphorylation site [posttranslational modification] 768494007168 intermolecular recognition site; other site 768494007169 dimerization interface [polypeptide binding]; other site 768494007170 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494007171 DNA binding site [nucleotide binding] 768494007172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494007173 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 768494007174 phosphorylation site [posttranslational modification] 768494007175 dimer interface [polypeptide binding]; other site 768494007176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494007177 ATP binding site [chemical binding]; other site 768494007178 Mg2+ binding site [ion binding]; other site 768494007179 G-X-G motif; other site 768494007180 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 768494007181 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768494007182 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494007183 ABC transporter; Region: ABC_tran_2; pfam12848 768494007184 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494007185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494007186 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494007187 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 768494007188 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768494007189 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768494007190 Walker A/P-loop; other site 768494007191 ATP binding site [chemical binding]; other site 768494007192 Q-loop/lid; other site 768494007193 ABC transporter signature motif; other site 768494007194 Walker B; other site 768494007195 D-loop; other site 768494007196 H-loop/switch region; other site 768494007197 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768494007198 FtsX-like permease family; Region: FtsX; pfam02687 768494007199 hypothetical protein; Provisional; Region: PRK06760 768494007200 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 768494007201 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 768494007202 homoserine dehydrogenase; Validated; Region: PRK06813 768494007203 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768494007204 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768494007205 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768494007206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494007207 DNA-binding site [nucleotide binding]; DNA binding site 768494007208 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494007209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494007210 homodimer interface [polypeptide binding]; other site 768494007211 catalytic residue [active] 768494007212 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 768494007213 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768494007214 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768494007215 Putative transcription activator [Transcription]; Region: TenA; COG0819 768494007216 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 768494007217 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 768494007218 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 768494007219 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 768494007220 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 768494007221 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 768494007222 Protein of unknown function; Region: DUF3658; pfam12395 768494007223 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 768494007224 Cytochrome P450; Region: p450; cl12078 768494007225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494007226 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494007227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494007228 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 768494007229 trimer interface [polypeptide binding]; other site 768494007230 active site 768494007231 substrate binding site [chemical binding]; other site 768494007232 CoA binding site [chemical binding]; other site 768494007233 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 768494007234 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494007235 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768494007236 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 768494007237 Cytochrome P450; Region: p450; cl12078 768494007238 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 768494007239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494007240 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768494007241 active site 768494007242 motif I; other site 768494007243 motif II; other site 768494007244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494007245 PAS domain S-box; Region: sensory_box; TIGR00229 768494007246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494007247 putative active site [active] 768494007248 heme pocket [chemical binding]; other site 768494007249 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 768494007250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494007251 dimer interface [polypeptide binding]; other site 768494007252 phosphorylation site [posttranslational modification] 768494007253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494007254 ATP binding site [chemical binding]; other site 768494007255 Mg2+ binding site [ion binding]; other site 768494007256 G-X-G motif; other site 768494007257 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 768494007258 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768494007259 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768494007260 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494007261 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 768494007262 glycosyltransferase, MGT family; Region: MGT; TIGR01426 768494007263 active site 768494007264 TDP-binding site; other site 768494007265 acceptor substrate-binding pocket; other site 768494007266 homodimer interface [polypeptide binding]; other site 768494007267 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 768494007268 aspartate racemase; Region: asp_race; TIGR00035 768494007269 hypothetical protein; Provisional; Region: PRK13661 768494007270 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 768494007271 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 768494007272 Walker A/P-loop; other site 768494007273 ATP binding site [chemical binding]; other site 768494007274 Q-loop/lid; other site 768494007275 ABC transporter signature motif; other site 768494007276 Walker B; other site 768494007277 D-loop; other site 768494007278 H-loop/switch region; other site 768494007279 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 768494007280 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 768494007281 Walker A/P-loop; other site 768494007282 ATP binding site [chemical binding]; other site 768494007283 Q-loop/lid; other site 768494007284 ABC transporter signature motif; other site 768494007285 Walker B; other site 768494007286 D-loop; other site 768494007287 H-loop/switch region; other site 768494007288 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 768494007289 potential frameshift: common BLAST hit: gi|227814539|ref|YP_002814548.1| sporulation kinase B 768494007290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494007291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494007292 dimer interface [polypeptide binding]; other site 768494007293 phosphorylation site [posttranslational modification] 768494007294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494007295 ATP binding site [chemical binding]; other site 768494007296 Mg2+ binding site [ion binding]; other site 768494007297 G-X-G motif; other site 768494007298 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 768494007299 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768494007300 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 768494007301 active site 768494007302 ATP binding site [chemical binding]; other site 768494007303 substrate binding site [chemical binding]; other site 768494007304 activation loop (A-loop); other site 768494007305 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 768494007306 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768494007307 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768494007308 NAD(P) binding site [chemical binding]; other site 768494007309 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 768494007310 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768494007311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494007312 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 768494007313 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 768494007314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494007315 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494007316 putative substrate translocation pore; other site 768494007317 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494007318 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494007319 putative acetyltransferase; Provisional; Region: PRK03624 768494007320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007321 Coenzyme A binding pocket [chemical binding]; other site 768494007322 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 768494007323 EDD domain protein, DegV family; Region: DegV; TIGR00762 768494007324 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 768494007325 Putative amidotransferase; Region: DUF4066; pfam13278 768494007326 conserved cys residue [active] 768494007327 Predicted transcriptional regulator [Transcription]; Region: COG2378 768494007328 HTH domain; Region: HTH_11; pfam08279 768494007329 WYL domain; Region: WYL; pfam13280 768494007330 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 768494007331 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 768494007332 conserved cys residue [active] 768494007333 Protein of unknown function (DUF975); Region: DUF975; cl10504 768494007334 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494007335 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494007336 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 768494007337 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768494007338 DNA binding residues [nucleotide binding] 768494007339 putative dimer interface [polypeptide binding]; other site 768494007340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494007341 S-adenosylmethionine binding site [chemical binding]; other site 768494007342 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494007343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494007344 putative substrate translocation pore; other site 768494007345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007346 Coenzyme A binding pocket [chemical binding]; other site 768494007347 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 768494007348 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768494007349 active site 768494007350 catalytic site [active] 768494007351 metal binding site [ion binding]; metal-binding site 768494007352 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 768494007353 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494007354 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 768494007355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494007356 homodimer interface [polypeptide binding]; other site 768494007357 catalytic residue [active] 768494007358 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768494007359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494007360 DNA-binding site [nucleotide binding]; DNA binding site 768494007361 EamA-like transporter family; Region: EamA; pfam00892 768494007362 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768494007363 EamA-like transporter family; Region: EamA; pfam00892 768494007364 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 768494007365 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 768494007366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007367 Coenzyme A binding pocket [chemical binding]; other site 768494007368 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 768494007369 nudix motif; other site 768494007370 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 768494007371 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494007372 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494007373 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 768494007374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494007375 putative substrate translocation pore; other site 768494007376 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 768494007377 Cadmium resistance transporter; Region: Cad; pfam03596 768494007378 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 768494007379 nudix motif; other site 768494007380 DNA polymerase III subunit beta; Validated; Region: PRK06673 768494007381 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 768494007382 putative DNA binding surface [nucleotide binding]; other site 768494007383 dimer interface [polypeptide binding]; other site 768494007384 beta-clamp/clamp loader binding surface; other site 768494007385 beta-clamp/translesion DNA polymerase binding surface; other site 768494007386 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 768494007387 putative active site [active] 768494007388 nucleotide binding site [chemical binding]; other site 768494007389 nudix motif; other site 768494007390 putative metal binding site [ion binding]; other site 768494007391 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 768494007392 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768494007393 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 768494007394 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 768494007395 translation initiation factor IF-2; Provisional; Region: PRK14845 768494007396 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768494007397 homotrimer interaction site [polypeptide binding]; other site 768494007398 putative active site [active] 768494007399 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 768494007400 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 768494007401 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 768494007402 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 768494007403 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 768494007404 YxiJ-like protein; Region: YxiJ; pfam14176 768494007405 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 768494007406 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 768494007407 pentamer interface [polypeptide binding]; other site 768494007408 dodecaamer interface [polypeptide binding]; other site 768494007409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007410 Coenzyme A binding pocket [chemical binding]; other site 768494007411 metal-dependent hydrolase; Provisional; Region: PRK13291 768494007412 DinB superfamily; Region: DinB_2; pfam12867 768494007413 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494007414 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494007415 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 768494007416 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 768494007417 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768494007418 GIY-YIG motif/motif A; other site 768494007419 active site 768494007420 catalytic site [active] 768494007421 putative DNA binding site [nucleotide binding]; other site 768494007422 metal binding site [ion binding]; metal-binding site 768494007423 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494007424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007425 Coenzyme A binding pocket [chemical binding]; other site 768494007426 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 768494007427 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 768494007428 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768494007429 active site 768494007430 ATP binding site [chemical binding]; other site 768494007431 substrate binding site [chemical binding]; other site 768494007432 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 768494007433 nudix motif; other site 768494007434 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768494007435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768494007436 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 768494007437 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 768494007438 MepB protein; Region: MepB; pfam08877 768494007439 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 768494007440 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 768494007441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494007442 motif II; other site 768494007443 DinB superfamily; Region: DinB_2; pfam12867 768494007444 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 768494007445 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 768494007446 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 768494007447 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768494007448 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768494007449 tyrosine decarboxylase; Region: PLN02880 768494007450 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768494007451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768494007452 catalytic residue [active] 768494007453 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768494007454 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768494007455 acyl-activating enzyme (AAE) consensus motif; other site 768494007456 AMP binding site [chemical binding]; other site 768494007457 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768494007458 Condensation domain; Region: Condensation; pfam00668 768494007459 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768494007460 Nonribosomal peptide synthase; Region: NRPS; pfam08415 768494007461 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 768494007462 acyl-activating enzyme (AAE) consensus motif; other site 768494007463 AMP binding site [chemical binding]; other site 768494007464 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768494007465 Condensation domain; Region: Condensation; pfam00668 768494007466 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768494007467 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 768494007468 putative FMN binding site [chemical binding]; other site 768494007469 NADPH bind site [chemical binding]; other site 768494007470 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 768494007471 carbohydrate binding site [chemical binding]; other site 768494007472 pullulanase, type I; Region: pulA_typeI; TIGR02104 768494007473 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 768494007474 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 768494007475 Ca binding site [ion binding]; other site 768494007476 active site 768494007477 catalytic site [active] 768494007478 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 768494007479 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 768494007480 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 768494007481 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 768494007482 active site 768494007483 Zn binding site [ion binding]; other site 768494007484 Putative zinc-finger; Region: zf-HC2; pfam13490 768494007485 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 768494007486 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 768494007487 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494007488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494007489 DNA binding residues [nucleotide binding] 768494007490 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 768494007491 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 768494007492 SecY translocase; Region: SecY; pfam00344 768494007493 hypothetical protein; Validated; Region: PRK06672 768494007494 DnaA N-terminal domain; Region: DnaA_N; pfam11638 768494007495 DnaA N-terminal domain; Region: DnaA_N; pfam11638 768494007496 DnaA N-terminal domain; Region: DnaA_N; pfam11638 768494007497 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 768494007498 EamA-like transporter family; Region: EamA; pfam00892 768494007499 EamA-like transporter family; Region: EamA; pfam00892 768494007500 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768494007501 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494007502 DNA-binding site [nucleotide binding]; DNA binding site 768494007503 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494007504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494007505 homodimer interface [polypeptide binding]; other site 768494007506 catalytic residue [active] 768494007507 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768494007508 TAP-like protein; Region: Abhydrolase_4; pfam08386 768494007509 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 768494007510 Mg binding site [ion binding]; other site 768494007511 nucleotide binding site [chemical binding]; other site 768494007512 putative protofilament interface [polypeptide binding]; other site 768494007513 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 768494007514 Predicted membrane protein [Function unknown]; Region: COG4129 768494007515 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 768494007516 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494007517 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 768494007518 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 768494007519 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 768494007520 germination protein YpeB; Region: spore_YpeB; TIGR02889 768494007521 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 768494007522 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 768494007523 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 768494007524 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 768494007525 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494007526 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494007527 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 768494007528 arylformamidase; Region: trp_arylform; TIGR03035 768494007529 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768494007530 kynureninase; Region: kynureninase; TIGR01814 768494007531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768494007532 catalytic residue [active] 768494007533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494007534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494007535 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 768494007536 nudix motif; other site 768494007537 N-acetyltransferase; Region: Acetyltransf_2; cl00949 768494007538 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 768494007539 hydrophobic ligand binding site; other site 768494007540 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 768494007541 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 768494007542 GAF domain; Region: GAF; pfam01590 768494007543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494007544 Walker A motif; other site 768494007545 ATP binding site [chemical binding]; other site 768494007546 Walker B motif; other site 768494007547 arginine finger; other site 768494007548 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768494007549 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 768494007550 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007551 Coenzyme A binding pocket [chemical binding]; other site 768494007552 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768494007553 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768494007554 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768494007555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494007556 S-adenosylmethionine binding site [chemical binding]; other site 768494007557 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 768494007558 Predicted transcriptional regulator [Transcription]; Region: COG1959 768494007559 Transcriptional regulator; Region: Rrf2; pfam02082 768494007560 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 768494007561 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 768494007562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768494007563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494007564 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768494007565 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768494007566 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 768494007567 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768494007568 E3 interaction surface; other site 768494007569 lipoyl attachment site [posttranslational modification]; other site 768494007570 e3 binding domain; Region: E3_binding; pfam02817 768494007571 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768494007572 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 768494007573 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 768494007574 alpha subunit interface [polypeptide binding]; other site 768494007575 TPP binding site [chemical binding]; other site 768494007576 heterodimer interface [polypeptide binding]; other site 768494007577 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768494007578 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 768494007579 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 768494007580 tetramer interface [polypeptide binding]; other site 768494007581 TPP-binding site [chemical binding]; other site 768494007582 heterodimer interface [polypeptide binding]; other site 768494007583 phosphorylation loop region [posttranslational modification] 768494007584 DinB superfamily; Region: DinB_2; pfam12867 768494007585 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 768494007586 short chain dehydrogenase; Provisional; Region: PRK06914 768494007587 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768494007588 NADP binding site [chemical binding]; other site 768494007589 active site 768494007590 steroid binding site; other site 768494007591 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 768494007592 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 768494007593 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 768494007594 nudix motif; other site 768494007595 Protein phosphatase 2C; Region: PP2C_2; pfam13672 768494007596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494007597 dimer interface [polypeptide binding]; other site 768494007598 conserved gate region; other site 768494007599 putative PBP binding loops; other site 768494007600 ABC-ATPase subunit interface; other site 768494007601 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 768494007602 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 768494007603 Walker A/P-loop; other site 768494007604 ATP binding site [chemical binding]; other site 768494007605 Q-loop/lid; other site 768494007606 ABC transporter signature motif; other site 768494007607 Walker B; other site 768494007608 D-loop; other site 768494007609 H-loop/switch region; other site 768494007610 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 768494007611 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 768494007612 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768494007613 Clp protease; Region: CLP_protease; pfam00574 768494007614 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768494007615 oligomer interface [polypeptide binding]; other site 768494007616 active site residues [active] 768494007617 RNA polymerase factor sigma-70; Validated; Region: PRK06704 768494007618 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494007619 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 768494007620 DNA binding residues [nucleotide binding] 768494007621 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768494007622 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 768494007623 catalytic loop [active] 768494007624 iron binding site [ion binding]; other site 768494007625 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 768494007626 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768494007627 active site 768494007628 dimer interface [polypeptide binding]; other site 768494007629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007630 Coenzyme A binding pocket [chemical binding]; other site 768494007631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 768494007632 Chitin binding domain; Region: Chitin_bind_3; pfam03067 768494007633 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768494007634 Interdomain contacts; other site 768494007635 Cytokine receptor motif; other site 768494007636 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 768494007637 Interdomain contacts; other site 768494007638 Cytokine receptor motif; other site 768494007639 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 768494007640 topology modulation protein; Reviewed; Region: PRK08118 768494007641 AAA domain; Region: AAA_17; pfam13207 768494007642 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 768494007643 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 768494007644 substrate binding site [chemical binding]; other site 768494007645 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 768494007646 Protein of unknown function (DUF419); Region: DUF419; cl15265 768494007647 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 768494007648 Protein of unknown function; Region: DUF3658; pfam12395 768494007649 Protein of unknown function (DUF419); Region: DUF419; pfam04237 768494007650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007651 Coenzyme A binding pocket [chemical binding]; other site 768494007652 S-layer homology domain; Region: SLH; pfam00395 768494007653 S-layer homology domain; Region: SLH; pfam00395 768494007654 S-layer homology domain; Region: SLH; pfam00395 768494007655 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 768494007656 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494007657 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 768494007658 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 768494007659 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 768494007660 active site 768494007661 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 768494007662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007663 Coenzyme A binding pocket [chemical binding]; other site 768494007664 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 768494007665 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 768494007666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007667 Coenzyme A binding pocket [chemical binding]; other site 768494007668 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494007669 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768494007670 Protein of unknown function (DUF952); Region: DUF952; pfam06108 768494007671 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 768494007672 Part of AAA domain; Region: AAA_19; pfam13245 768494007673 Family description; Region: UvrD_C_2; pfam13538 768494007674 CAAX protease self-immunity; Region: Abi; pfam02517 768494007675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494007676 S-adenosylmethionine binding site [chemical binding]; other site 768494007677 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768494007678 putative active site pocket [active] 768494007679 dimerization interface [polypeptide binding]; other site 768494007680 putative catalytic residue [active] 768494007681 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 768494007682 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768494007683 ATP binding site [chemical binding]; other site 768494007684 putative Mg++ binding site [ion binding]; other site 768494007685 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494007686 nucleotide binding region [chemical binding]; other site 768494007687 ATP-binding site [chemical binding]; other site 768494007688 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 768494007689 HRDC domain; Region: HRDC; pfam00570 768494007690 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 768494007691 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 768494007692 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 768494007693 active site 768494007694 Zn binding site [ion binding]; other site 768494007695 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 768494007696 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768494007697 DHHA2 domain; Region: DHHA2; pfam02833 768494007698 Chitin binding domain; Region: Chitin_bind_3; pfam03067 768494007699 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768494007700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007701 Coenzyme A binding pocket [chemical binding]; other site 768494007702 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 768494007703 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768494007704 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 768494007705 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 768494007706 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768494007707 NAD(P) binding site [chemical binding]; other site 768494007708 catalytic residues [active] 768494007709 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768494007710 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 768494007711 inhibitor site; inhibition site 768494007712 active site 768494007713 dimer interface [polypeptide binding]; other site 768494007714 catalytic residue [active] 768494007715 Proline racemase; Region: Pro_racemase; pfam05544 768494007716 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768494007717 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768494007718 Proline racemase; Region: Pro_racemase; pfam05544 768494007719 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768494007720 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768494007721 PAS domain; Region: PAS; smart00091 768494007722 PAS domain; Region: PAS_9; pfam13426 768494007723 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768494007724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494007725 Walker A motif; other site 768494007726 ATP binding site [chemical binding]; other site 768494007727 Walker B motif; other site 768494007728 arginine finger; other site 768494007729 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768494007730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494007731 Walker A/P-loop; other site 768494007732 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768494007733 catalytic loop [active] 768494007734 iron binding site [ion binding]; other site 768494007735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 768494007736 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768494007737 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 768494007738 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 768494007739 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768494007740 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768494007741 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 768494007742 DltD N-terminal region; Region: DltD_N; pfam04915 768494007743 DltD central region; Region: DltD_M; pfam04918 768494007744 DltD C-terminal region; Region: DltD_C; pfam04914 768494007745 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494007746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007747 Coenzyme A binding pocket [chemical binding]; other site 768494007748 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768494007749 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494007750 peptide binding site [polypeptide binding]; other site 768494007751 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768494007752 NlpC/P60 family; Region: NLPC_P60; pfam00877 768494007753 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 768494007754 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 768494007755 active site 768494007756 Septum formation initiator; Region: DivIC; pfam04977 768494007757 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 768494007758 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 768494007759 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768494007760 active site 768494007761 catalytic motif [active] 768494007762 Zn binding site [ion binding]; other site 768494007763 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768494007764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494007765 S-adenosylmethionine binding site [chemical binding]; other site 768494007766 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 768494007767 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 768494007768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494007769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494007770 dimerization interface [polypeptide binding]; other site 768494007771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494007772 dimer interface [polypeptide binding]; other site 768494007773 phosphorylation site [posttranslational modification] 768494007774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494007775 ATP binding site [chemical binding]; other site 768494007776 Mg2+ binding site [ion binding]; other site 768494007777 G-X-G motif; other site 768494007778 potential frameshift: common BLAST hit: gi|227814328|ref|YP_002814337.1| DNA-binding response regulator 768494007779 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494007780 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494007781 DNA binding site [nucleotide binding] 768494007782 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494007783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494007784 active site 768494007785 phosphorylation site [posttranslational modification] 768494007786 intermolecular recognition site; other site 768494007787 dimerization interface [polypeptide binding]; other site 768494007788 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 768494007789 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 768494007790 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 768494007791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494007792 motif II; other site 768494007793 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 768494007794 Phosphotransferase enzyme family; Region: APH; pfam01636 768494007795 active site 768494007796 substrate binding site [chemical binding]; other site 768494007797 ATP binding site [chemical binding]; other site 768494007798 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 768494007799 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 768494007800 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 768494007801 Zn binding site [ion binding]; other site 768494007802 Short C-terminal domain; Region: SHOCT; pfam09851 768494007803 EDD domain protein, DegV family; Region: DegV; TIGR00762 768494007804 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 768494007805 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494007806 Coenzyme A binding pocket [chemical binding]; other site 768494007807 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 768494007808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494007809 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494007810 putative substrate translocation pore; other site 768494007811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494007812 putative substrate translocation pore; other site 768494007813 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 768494007814 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 768494007815 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 768494007816 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 768494007817 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 768494007818 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 768494007819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494007820 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494007821 putative substrate translocation pore; other site 768494007822 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 768494007823 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 768494007824 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 768494007825 active site 768494007826 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 768494007827 potential frameshift: common BLAST hit: gi|227814301|ref|YP_002814310.1| UbiE/COQ5 family methyltransferase 768494007828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494007829 S-adenosylmethionine binding site [chemical binding]; other site 768494007830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494007831 putative substrate translocation pore; other site 768494007832 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494007833 aspartate aminotransferase; Provisional; Region: PRK07681 768494007834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494007835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494007836 homodimer interface [polypeptide binding]; other site 768494007837 catalytic residue [active] 768494007838 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768494007839 pantothenate kinase; Provisional; Region: PRK13317 768494007840 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 768494007841 CAAX protease self-immunity; Region: Abi; pfam02517 768494007842 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 768494007843 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 768494007844 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494007845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494007846 Walker A/P-loop; other site 768494007847 ATP binding site [chemical binding]; other site 768494007848 Q-loop/lid; other site 768494007849 ABC transporter signature motif; other site 768494007850 Walker B; other site 768494007851 D-loop; other site 768494007852 H-loop/switch region; other site 768494007853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494007854 DNA-binding site [nucleotide binding]; DNA binding site 768494007855 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 768494007856 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 768494007857 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 768494007858 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 768494007859 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 768494007860 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768494007861 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768494007862 HNH endonuclease; Region: HNH_5; pfam14279 768494007863 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 768494007864 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 768494007865 active site 768494007866 dimer interface [polypeptide binding]; other site 768494007867 non-prolyl cis peptide bond; other site 768494007868 insertion regions; other site 768494007869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768494007870 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768494007871 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 768494007872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768494007873 substrate binding pocket [chemical binding]; other site 768494007874 membrane-bound complex binding site; other site 768494007875 hinge residues; other site 768494007876 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 768494007877 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768494007878 Walker A/P-loop; other site 768494007879 ATP binding site [chemical binding]; other site 768494007880 Q-loop/lid; other site 768494007881 ABC transporter signature motif; other site 768494007882 Walker B; other site 768494007883 D-loop; other site 768494007884 H-loop/switch region; other site 768494007885 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494007886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494007887 Protein of unknown function (DUF402); Region: DUF402; pfam04167 768494007888 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 768494007889 nudix motif; other site 768494007890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768494007891 binding surface 768494007892 TPR motif; other site 768494007893 hypothetical protein; Provisional; Region: PRK09620 768494007894 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 768494007895 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 768494007896 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 768494007897 Coenzyme A binding pocket [chemical binding]; other site 768494007898 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 768494007899 DinB superfamily; Region: DinB_2; pfam12867 768494007900 Protein of unknown function (DUF664); Region: DUF664; pfam04978 768494007901 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 768494007902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007903 Coenzyme A binding pocket [chemical binding]; other site 768494007904 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494007905 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494007906 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 768494007907 active site 768494007908 NTP binding site [chemical binding]; other site 768494007909 metal binding triad [ion binding]; metal-binding site 768494007910 antibiotic binding site [chemical binding]; other site 768494007911 A new structural DNA glycosylase; Region: AlkD_like; cd06561 768494007912 active site 768494007913 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 768494007914 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 768494007915 NodB motif; other site 768494007916 active site 768494007917 catalytic site [active] 768494007918 Zn binding site [ion binding]; other site 768494007919 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 768494007920 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 768494007921 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 768494007922 Sulfatase; Region: Sulfatase; pfam00884 768494007923 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 768494007924 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494007925 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494007926 ABC transporter; Region: ABC_tran_2; pfam12848 768494007927 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494007928 hypothetical protein; Provisional; Region: PRK06761 768494007929 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 768494007930 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 768494007931 MMPL family; Region: MMPL; pfam03176 768494007932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494007933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494007934 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 768494007935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007936 Coenzyme A binding pocket [chemical binding]; other site 768494007937 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 768494007938 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 768494007939 hinge; other site 768494007940 active site 768494007941 prephenate dehydrogenase; Validated; Region: PRK06545 768494007942 prephenate dehydrogenase; Validated; Region: PRK08507 768494007943 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 768494007944 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 768494007945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494007946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494007947 homodimer interface [polypeptide binding]; other site 768494007948 catalytic residue [active] 768494007949 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 768494007950 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 768494007951 Tetramer interface [polypeptide binding]; other site 768494007952 active site 768494007953 FMN-binding site [chemical binding]; other site 768494007954 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 768494007955 Chorismate mutase type II; Region: CM_2; cl00693 768494007956 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 768494007957 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 768494007958 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 768494007959 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 768494007960 Isochorismatase family; Region: Isochorismatase; pfam00857 768494007961 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768494007962 catalytic triad [active] 768494007963 conserved cis-peptide bond; other site 768494007964 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494007965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494007966 Coenzyme A binding pocket [chemical binding]; other site 768494007967 YfzA-like protein; Region: YfzA; pfam14118 768494007968 hypothetical protein; Provisional; Region: PRK06762 768494007969 hypothetical protein; Provisional; Region: PRK06762 768494007970 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494007971 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494007972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 768494007973 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 768494007974 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494007975 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494007976 DNA binding residues [nucleotide binding] 768494007977 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 768494007978 malate:quinone oxidoreductase; Validated; Region: PRK05257 768494007979 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 768494007980 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 768494007981 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 768494007982 ligand binding site [chemical binding]; other site 768494007983 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768494007984 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768494007985 TM-ABC transporter signature motif; other site 768494007986 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768494007987 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768494007988 TM-ABC transporter signature motif; other site 768494007989 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768494007990 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768494007991 Walker A/P-loop; other site 768494007992 ATP binding site [chemical binding]; other site 768494007993 Q-loop/lid; other site 768494007994 ABC transporter signature motif; other site 768494007995 Walker B; other site 768494007996 D-loop; other site 768494007997 H-loop/switch region; other site 768494007998 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768494007999 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 768494008000 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 768494008001 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 768494008002 putative N- and C-terminal domain interface [polypeptide binding]; other site 768494008003 putative MgATP binding site [chemical binding]; other site 768494008004 putative active site [active] 768494008005 catalytic site [active] 768494008006 metal binding site [ion binding]; metal-binding site 768494008007 putative carbohydrate binding site [chemical binding]; other site 768494008008 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768494008009 Cupin domain; Region: Cupin_2; pfam07883 768494008010 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 768494008011 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 768494008012 putative active site; other site 768494008013 catalytic residue [active] 768494008014 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494008015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494008016 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 768494008017 active site 768494008018 NTP binding site [chemical binding]; other site 768494008019 metal binding triad [ion binding]; metal-binding site 768494008020 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 768494008021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494008022 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494008023 putative substrate translocation pore; other site 768494008024 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494008025 putative DNA binding site [nucleotide binding]; other site 768494008026 putative Zn2+ binding site [ion binding]; other site 768494008027 DinB superfamily; Region: DinB_2; pfam12867 768494008028 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768494008029 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768494008030 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768494008031 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 768494008032 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 768494008033 putative catalytic cysteine [active] 768494008034 gamma-glutamyl kinase; Provisional; Region: PRK05429 768494008035 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 768494008036 nucleotide binding site [chemical binding]; other site 768494008037 homotetrameric interface [polypeptide binding]; other site 768494008038 putative phosphate binding site [ion binding]; other site 768494008039 putative allosteric binding site; other site 768494008040 PUA domain; Region: PUA; pfam01472 768494008041 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768494008042 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 768494008043 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 768494008044 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 768494008045 putative metal binding site [ion binding]; other site 768494008046 putative dimer interface [polypeptide binding]; other site 768494008047 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768494008048 Transcriptional regulator [Transcription]; Region: IclR; COG1414 768494008049 Bacterial transcriptional regulator; Region: IclR; pfam01614 768494008050 S-methylmethionine transporter; Provisional; Region: PRK11387 768494008051 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 768494008052 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 768494008053 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 768494008054 putative di-iron ligands [ion binding]; other site 768494008055 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 768494008056 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 768494008057 dimer interface [polypeptide binding]; other site 768494008058 active site 768494008059 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 768494008060 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494008061 salt bridge; other site 768494008062 non-specific DNA binding site [nucleotide binding]; other site 768494008063 sequence-specific DNA binding site [nucleotide binding]; other site 768494008064 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 768494008065 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 768494008066 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 768494008067 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 768494008068 LytTr DNA-binding domain; Region: LytTR; pfam04397 768494008069 uridine kinase; Provisional; Region: PRK07667 768494008070 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494008071 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494008072 Coenzyme A binding pocket [chemical binding]; other site 768494008073 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494008074 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768494008075 active site 768494008076 metal binding site [ion binding]; metal-binding site 768494008077 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 768494008078 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494008079 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768494008080 MoxR-like ATPases [General function prediction only]; Region: COG0714 768494008081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494008082 Walker A motif; other site 768494008083 ATP binding site [chemical binding]; other site 768494008084 Walker B motif; other site 768494008085 arginine finger; other site 768494008086 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 768494008087 Protein of unknown function DUF58; Region: DUF58; pfam01882 768494008088 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 768494008089 proline/glycine betaine transporter; Provisional; Region: PRK10642 768494008090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494008091 putative substrate translocation pore; other site 768494008092 potential frameshift: common BLAST hit: gi|227814177|ref|YP_002814186.1| glycosyl transferase family protein 768494008093 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494008094 active site 768494008095 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494008096 active site 768494008097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768494008098 active site 768494008099 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 768494008100 Ligand binding site; other site 768494008101 Putative Catalytic site; other site 768494008102 DXD motif; other site 768494008103 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494008104 active site 768494008105 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 768494008106 Ligand binding site; other site 768494008107 Putative Catalytic site; other site 768494008108 DXD motif; other site 768494008109 acetylornithine aminotransferase; Provisional; Region: PRK02627 768494008110 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768494008111 inhibitor-cofactor binding pocket; inhibition site 768494008112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494008113 catalytic residue [active] 768494008114 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 768494008115 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 768494008116 tetramer interface [polypeptide binding]; other site 768494008117 heme binding pocket [chemical binding]; other site 768494008118 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 768494008119 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768494008120 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 768494008121 active site 768494008122 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 768494008123 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494008124 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494008125 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 768494008126 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 768494008127 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 768494008128 Protein of unknown function DUF58; Region: DUF58; pfam01882 768494008129 MoxR-like ATPases [General function prediction only]; Region: COG0714 768494008130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494008131 Walker A motif; other site 768494008132 ATP binding site [chemical binding]; other site 768494008133 Walker B motif; other site 768494008134 arginine finger; other site 768494008135 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768494008136 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 768494008137 dimer interface [polypeptide binding]; other site 768494008138 FMN binding site [chemical binding]; other site 768494008139 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494008140 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494008141 putative DNA binding site [nucleotide binding]; other site 768494008142 putative Zn2+ binding site [ion binding]; other site 768494008143 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 768494008144 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 768494008145 G1 box; other site 768494008146 putative GEF interaction site [polypeptide binding]; other site 768494008147 GTP/Mg2+ binding site [chemical binding]; other site 768494008148 Switch I region; other site 768494008149 G2 box; other site 768494008150 G3 box; other site 768494008151 Switch II region; other site 768494008152 G4 box; other site 768494008153 G5 box; other site 768494008154 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 768494008155 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 768494008156 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 768494008157 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 768494008158 nudix motif; other site 768494008159 YfzA-like protein; Region: YfzA; pfam14118 768494008160 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 768494008161 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494008162 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 768494008163 Walker A/P-loop; other site 768494008164 ATP binding site [chemical binding]; other site 768494008165 Q-loop/lid; other site 768494008166 ABC transporter signature motif; other site 768494008167 Walker B; other site 768494008168 D-loop; other site 768494008169 H-loop/switch region; other site 768494008170 Predicted transcriptional regulators [Transcription]; Region: COG1725 768494008171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494008172 DNA-binding site [nucleotide binding]; DNA binding site 768494008173 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 768494008174 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768494008175 putative NAD(P) binding site [chemical binding]; other site 768494008176 active site 768494008177 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768494008178 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768494008179 Walker A/P-loop; other site 768494008180 ATP binding site [chemical binding]; other site 768494008181 Q-loop/lid; other site 768494008182 ABC transporter signature motif; other site 768494008183 Walker B; other site 768494008184 D-loop; other site 768494008185 H-loop/switch region; other site 768494008186 FtsX-like permease family; Region: FtsX; pfam02687 768494008187 FtsX-like permease family; Region: FtsX; pfam02687 768494008188 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494008189 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494008190 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768494008191 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494008192 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 768494008193 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768494008194 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494008195 Coenzyme A binding pocket [chemical binding]; other site 768494008196 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 768494008197 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 768494008198 nudix motif; other site 768494008199 EamA-like transporter family; Region: EamA; pfam00892 768494008200 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768494008201 EamA-like transporter family; Region: EamA; pfam00892 768494008202 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768494008203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494008204 DNA-binding site [nucleotide binding]; DNA binding site 768494008205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494008206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494008207 homodimer interface [polypeptide binding]; other site 768494008208 catalytic residue [active] 768494008209 hypothetical protein; Validated; Region: PRK00124 768494008210 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 768494008211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494008212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 768494008213 phosphorylation site [posttranslational modification] 768494008214 dimer interface [polypeptide binding]; other site 768494008215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494008216 ATP binding site [chemical binding]; other site 768494008217 Mg2+ binding site [ion binding]; other site 768494008218 G-X-G motif; other site 768494008219 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494008220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494008221 active site 768494008222 phosphorylation site [posttranslational modification] 768494008223 intermolecular recognition site; other site 768494008224 dimerization interface [polypeptide binding]; other site 768494008225 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494008226 DNA binding site [nucleotide binding] 768494008227 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768494008228 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 768494008229 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 768494008230 uridine kinase; Validated; Region: PRK06696 768494008231 active site 768494008232 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 768494008233 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768494008234 active site 768494008235 metal binding site [ion binding]; metal-binding site 768494008236 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 768494008237 Phosphotransferase enzyme family; Region: APH; pfam01636 768494008238 active site 768494008239 substrate binding site [chemical binding]; other site 768494008240 ATP binding site [chemical binding]; other site 768494008241 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 768494008242 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768494008243 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494008244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494008245 Coenzyme A binding pocket [chemical binding]; other site 768494008246 lysine transporter; Provisional; Region: PRK10836 768494008247 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 768494008248 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 768494008249 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768494008250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494008251 S-adenosylmethionine binding site [chemical binding]; other site 768494008252 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 768494008253 putative active site [active] 768494008254 nucleotide binding site [chemical binding]; other site 768494008255 nudix motif; other site 768494008256 putative metal binding site [ion binding]; other site 768494008257 Cephalosporin hydroxylase; Region: CmcI; pfam04989 768494008258 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 768494008259 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768494008260 Catalytic site [active] 768494008261 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 768494008262 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768494008263 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494008264 NAD-dependent deacetylase; Provisional; Region: PRK00481 768494008265 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 768494008266 NAD+ binding site [chemical binding]; other site 768494008267 substrate binding site [chemical binding]; other site 768494008268 Zn binding site [ion binding]; other site 768494008269 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 768494008270 putative substrate binding pocket [chemical binding]; other site 768494008271 AC domain interface; other site 768494008272 catalytic triad [active] 768494008273 AB domain interface; other site 768494008274 interchain disulfide; other site 768494008275 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 768494008276 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 768494008277 Predicted membrane protein [Function unknown]; Region: COG3817 768494008278 Protein of unknown function (DUF979); Region: DUF979; pfam06166 768494008279 Protein of unknown function (DUF969); Region: DUF969; pfam06149 768494008280 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 768494008281 putative active site [active] 768494008282 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 768494008283 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 768494008284 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 768494008285 Transcriptional regulator [Transcription]; Region: IclR; COG1414 768494008286 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768494008287 Bacterial transcriptional regulator; Region: IclR; pfam01614 768494008288 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 768494008289 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768494008290 Catalytic site [active] 768494008291 CutC family; Region: CutC; cl01218 768494008292 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 768494008293 stage II sporulation protein P; Region: spore_II_P; TIGR02867 768494008294 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494008295 dimerization interface [polypeptide binding]; other site 768494008296 putative DNA binding site [nucleotide binding]; other site 768494008297 putative Zn2+ binding site [ion binding]; other site 768494008298 DinB superfamily; Region: DinB_2; pfam12867 768494008299 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768494008300 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768494008301 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768494008302 Uncharacterized conserved protein [Function unknown]; Region: COG1434 768494008303 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768494008304 putative active site [active] 768494008305 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494008306 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494008307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 768494008308 Nucleoside recognition; Region: Gate; pfam07670 768494008309 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 768494008310 Phosphotransferase enzyme family; Region: APH; pfam01636 768494008311 putative active site [active] 768494008312 putative substrate binding site [chemical binding]; other site 768494008313 ATP binding site [chemical binding]; other site 768494008314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494008315 Coenzyme A binding pocket [chemical binding]; other site 768494008316 Uncharacterized conserved protein [Function unknown]; Region: COG1633 768494008317 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 768494008318 dinuclear metal binding motif [ion binding]; other site 768494008319 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 768494008320 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 768494008321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494008322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494008323 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 768494008324 phosphoenolpyruvate synthase; Validated; Region: PRK06241 768494008325 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 768494008326 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768494008327 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494008328 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 768494008329 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 768494008330 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 768494008331 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 768494008332 LysE type translocator; Region: LysE; pfam01810 768494008333 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 768494008334 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 768494008335 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 768494008336 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 768494008337 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 768494008338 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 768494008339 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 768494008340 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768494008341 NAD binding site [chemical binding]; other site 768494008342 catalytic Zn binding site [ion binding]; other site 768494008343 structural Zn binding site [ion binding]; other site 768494008344 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 768494008345 dimanganese center [ion binding]; other site 768494008346 aspartate ammonia-lyase; Provisional; Region: PRK14515 768494008347 Aspartase; Region: Aspartase; cd01357 768494008348 active sites [active] 768494008349 tetramer interface [polypeptide binding]; other site 768494008350 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 768494008351 active site 768494008352 homodimer interface [polypeptide binding]; other site 768494008353 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494008354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494008355 non-specific DNA binding site [nucleotide binding]; other site 768494008356 sequence-specific DNA binding site [nucleotide binding]; other site 768494008357 salt bridge; other site 768494008358 Integrase core domain; Region: rve_3; cl15866 768494008359 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768494008360 GIY-YIG motif/motif A; other site 768494008361 active site 768494008362 catalytic site [active] 768494008363 putative DNA binding site [nucleotide binding]; other site 768494008364 metal binding site [ion binding]; metal-binding site 768494008365 amino acid transporter; Region: 2A0306; TIGR00909 768494008366 Spore germination protein; Region: Spore_permease; cl17796 768494008367 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 768494008368 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 768494008369 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768494008370 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 768494008371 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 768494008372 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768494008373 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 768494008374 putative NAD(P) binding site [chemical binding]; other site 768494008375 potential frameshift: common BLAST hit: gi|376266991|ref|YP_005119703.1| Hypothetical protein 768494008376 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 768494008377 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 768494008378 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 768494008379 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 768494008380 Spore germination protein; Region: Spore_permease; cl17796 768494008381 Spore germination protein; Region: Spore_permease; cl17796 768494008382 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 768494008383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494008384 Response regulator receiver domain; Region: Response_reg; pfam00072 768494008385 active site 768494008386 phosphorylation site [posttranslational modification] 768494008387 intermolecular recognition site; other site 768494008388 dimerization interface [polypeptide binding]; other site 768494008389 YcbB domain; Region: YcbB; pfam08664 768494008390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494008391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494008392 ATP binding site [chemical binding]; other site 768494008393 Mg2+ binding site [ion binding]; other site 768494008394 G-X-G motif; other site 768494008395 glutaminase; Reviewed; Region: PRK12357 768494008396 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 768494008397 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768494008398 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 768494008399 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 768494008400 transmembrane helices; other site 768494008401 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 768494008402 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 768494008403 active site 768494008404 active site 768494008405 Erythromycin esterase; Region: Erythro_esteras; cl17110 768494008406 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 768494008407 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 768494008408 putative active site [active] 768494008409 putative metal binding site [ion binding]; other site 768494008410 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768494008411 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 768494008412 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 768494008413 tetramer interface [polypeptide binding]; other site 768494008414 heme binding pocket [chemical binding]; other site 768494008415 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768494008416 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768494008417 Isochorismatase family; Region: Isochorismatase; pfam00857 768494008418 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768494008419 catalytic triad [active] 768494008420 dimer interface [polypeptide binding]; other site 768494008421 conserved cis-peptide bond; other site 768494008422 Isochorismatase family; Region: Isochorismatase; pfam00857 768494008423 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768494008424 catalytic triad [active] 768494008425 dimer interface [polypeptide binding]; other site 768494008426 conserved cis-peptide bond; other site 768494008427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 768494008428 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 768494008429 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 768494008430 active site 768494008431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768494008432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494008433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768494008434 dimerization interface [polypeptide binding]; other site 768494008435 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 768494008436 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 768494008437 Cl binding site [ion binding]; other site 768494008438 oligomer interface [polypeptide binding]; other site 768494008439 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 768494008440 Mg binding site [ion binding]; other site 768494008441 nucleotide binding site [chemical binding]; other site 768494008442 putative protofilament interface [polypeptide binding]; other site 768494008443 Heat induced stress protein YflT; Region: YflT; pfam11181 768494008444 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 768494008445 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 768494008446 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 768494008447 TspO/MBR family; Region: TspO_MBR; pfam03073 768494008448 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 768494008449 DNA photolyase; Region: DNA_photolyase; pfam00875 768494008450 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 768494008451 zinc binding site [ion binding]; other site 768494008452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 768494008453 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 768494008454 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 768494008455 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768494008456 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 768494008457 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768494008458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494008459 Coenzyme A binding pocket [chemical binding]; other site 768494008460 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 768494008461 UbiA prenyltransferase family; Region: UbiA; pfam01040 768494008462 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768494008463 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 768494008464 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 768494008465 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 768494008466 metal binding site [ion binding]; metal-binding site 768494008467 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768494008468 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494008469 ABC-ATPase subunit interface; other site 768494008470 dimer interface [polypeptide binding]; other site 768494008471 putative PBP binding regions; other site 768494008472 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 768494008473 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768494008474 DJ-1 family protein; Region: not_thiJ; TIGR01383 768494008475 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 768494008476 conserved cys residue [active] 768494008477 Phosphotransferase enzyme family; Region: APH; pfam01636 768494008478 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 768494008479 active site 768494008480 ATP binding site [chemical binding]; other site 768494008481 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 768494008482 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 768494008483 Low molecular weight phosphatase family; Region: LMWPc; cd00115 768494008484 active site 768494008485 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 768494008486 arsenical-resistance protein; Region: acr3; TIGR00832 768494008487 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494008488 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 768494008489 putative metal binding site [ion binding]; other site 768494008490 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494008491 dimerization interface [polypeptide binding]; other site 768494008492 putative DNA binding site [nucleotide binding]; other site 768494008493 putative Zn2+ binding site [ion binding]; other site 768494008494 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 768494008495 DnaJ domain; Region: DnaJ; pfam00226 768494008496 HSP70 interaction site [polypeptide binding]; other site 768494008497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494008498 binding surface 768494008499 TPR motif; other site 768494008500 TPR repeat; Region: TPR_11; pfam13414 768494008501 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 768494008502 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 768494008503 nucleotide binding site [chemical binding]; other site 768494008504 putative NEF/HSP70 interaction site [polypeptide binding]; other site 768494008505 SBD interface [polypeptide binding]; other site 768494008506 short chain dehydrogenase; Provisional; Region: PRK12746 768494008507 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 768494008508 NADP binding site [chemical binding]; other site 768494008509 homodimer interface [polypeptide binding]; other site 768494008510 active site 768494008511 substrate binding site [chemical binding]; other site 768494008512 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 768494008513 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494008514 putative DNA binding site [nucleotide binding]; other site 768494008515 putative Zn2+ binding site [ion binding]; other site 768494008516 AsnC family; Region: AsnC_trans_reg; pfam01037 768494008517 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 768494008518 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768494008519 metal binding site [ion binding]; metal-binding site 768494008520 AAA domain; Region: AAA_11; pfam13086 768494008521 Part of AAA domain; Region: AAA_19; pfam13245 768494008522 Erp protein C-terminus; Region: Erp_C; pfam06780 768494008523 AAA domain; Region: AAA_30; pfam13604 768494008524 AAA domain; Region: AAA_12; pfam13087 768494008525 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 768494008526 putative active site [active] 768494008527 catalytic site [active] 768494008528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494008529 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768494008530 active site 768494008531 metal binding site [ion binding]; metal-binding site 768494008532 HEAT repeats; Region: HEAT_2; pfam13646 768494008533 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 768494008534 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768494008535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494008536 putative transporter; Provisional; Region: PRK11021 768494008537 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494008538 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494008539 hypothetical protein; Provisional; Region: PRK06770 768494008540 putative monooxygenase; Provisional; Region: PRK11118 768494008541 DoxX-like family; Region: DoxX_2; pfam13564 768494008542 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768494008543 MarR family; Region: MarR_2; pfam12802 768494008544 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 768494008545 Cytochrome P450; Region: p450; pfam00067 768494008546 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 768494008547 Flavodoxin; Region: Flavodoxin_1; pfam00258 768494008548 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 768494008549 FAD binding pocket [chemical binding]; other site 768494008550 FAD binding motif [chemical binding]; other site 768494008551 catalytic residues [active] 768494008552 NAD binding pocket [chemical binding]; other site 768494008553 phosphate binding motif [ion binding]; other site 768494008554 beta-alpha-beta structure motif; other site 768494008555 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768494008556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494008557 putative substrate translocation pore; other site 768494008558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494008559 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 768494008560 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494008561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494008562 active site 768494008563 phosphorylation site [posttranslational modification] 768494008564 intermolecular recognition site; other site 768494008565 dimerization interface [polypeptide binding]; other site 768494008566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494008567 DNA binding site [nucleotide binding] 768494008568 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494008569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494008570 dimerization interface [polypeptide binding]; other site 768494008571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494008572 dimer interface [polypeptide binding]; other site 768494008573 phosphorylation site [posttranslational modification] 768494008574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494008575 ATP binding site [chemical binding]; other site 768494008576 G-X-G motif; other site 768494008577 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 768494008578 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768494008579 D-cysteine desulfhydrase; Validated; Region: PRK03910 768494008580 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 768494008581 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768494008582 catalytic residue [active] 768494008583 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 768494008584 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768494008585 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 768494008586 active site 768494008587 metal binding site [ion binding]; metal-binding site 768494008588 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494008589 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494008590 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494008591 sequence-specific DNA binding site [nucleotide binding]; other site 768494008592 salt bridge; other site 768494008593 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 768494008594 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 768494008595 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 768494008596 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768494008597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494008598 NAD(P) binding site [chemical binding]; other site 768494008599 active site 768494008600 hypothetical protein; Provisional; Region: PRK06849 768494008601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494008602 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 768494008603 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 768494008604 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768494008605 dimer interface [polypeptide binding]; other site 768494008606 active site 768494008607 CoA binding pocket [chemical binding]; other site 768494008608 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 768494008609 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 768494008610 AAA domain; Region: AAA_33; pfam13671 768494008611 AAA domain; Region: AAA_17; pfam13207 768494008612 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 768494008613 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 768494008614 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768494008615 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768494008616 Walker A/P-loop; other site 768494008617 ATP binding site [chemical binding]; other site 768494008618 Q-loop/lid; other site 768494008619 ABC transporter signature motif; other site 768494008620 Walker B; other site 768494008621 D-loop; other site 768494008622 H-loop/switch region; other site 768494008623 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768494008624 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768494008625 FtsX-like permease family; Region: FtsX; pfam02687 768494008626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494008627 putative DNA binding site [nucleotide binding]; other site 768494008628 putative Zn2+ binding site [ion binding]; other site 768494008629 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494008630 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 768494008631 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494008632 dimerization interface [polypeptide binding]; other site 768494008633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494008634 dimer interface [polypeptide binding]; other site 768494008635 phosphorylation site [posttranslational modification] 768494008636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494008637 ATP binding site [chemical binding]; other site 768494008638 Mg2+ binding site [ion binding]; other site 768494008639 G-X-G motif; other site 768494008640 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494008641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494008642 active site 768494008643 phosphorylation site [posttranslational modification] 768494008644 intermolecular recognition site; other site 768494008645 dimerization interface [polypeptide binding]; other site 768494008646 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494008647 DNA binding site [nucleotide binding] 768494008648 Predicted membrane protein [Function unknown]; Region: COG2364 768494008649 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768494008650 MarR family; Region: MarR; pfam01047 768494008651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494008652 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 768494008653 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768494008654 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494008655 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768494008656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494008657 D-galactonate transporter; Region: 2A0114; TIGR00893 768494008658 putative substrate translocation pore; other site 768494008659 Uncharacterized conserved protein [Function unknown]; Region: COG1556 768494008660 potential frameshift: common BLAST hit: gi|227813943|ref|YP_002813952.1| iron-sulfur cluster-binding protein 768494008661 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 768494008662 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 768494008663 4Fe-4S binding domain; Region: Fer4; pfam00037 768494008664 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 768494008665 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 768494008666 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 768494008667 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 768494008668 Cysteine-rich domain; Region: CCG; pfam02754 768494008669 Cysteine-rich domain; Region: CCG; pfam02754 768494008670 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768494008671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494008672 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768494008673 dimerization interface [polypeptide binding]; other site 768494008674 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 768494008675 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 768494008676 putative dimer interface [polypeptide binding]; other site 768494008677 catalytic triad [active] 768494008678 potential frameshift: common BLAST hit: gi|376267017|ref|YP_005119729.1| Hypothetical protein 768494008679 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768494008680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494008681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494008682 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768494008683 active site 768494008684 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 768494008685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494008686 putative substrate translocation pore; other site 768494008687 potential frameshift: common BLAST hit: gi|229604283|ref|YP_002867460.1| oxidoreductase, Gfo/Idh/MocA family 768494008688 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768494008689 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768494008690 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768494008691 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 768494008692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494008693 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768494008694 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768494008695 inhibitor-cofactor binding pocket; inhibition site 768494008696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494008697 catalytic residue [active] 768494008698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768494008699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768494008700 DNA binding site [nucleotide binding] 768494008701 domain linker motif; other site 768494008702 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 768494008703 putative dimerization interface [polypeptide binding]; other site 768494008704 putative ligand binding site [chemical binding]; other site 768494008705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768494008706 TPR motif; other site 768494008707 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768494008708 binding surface 768494008709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494008710 TPR motif; other site 768494008711 binding surface 768494008712 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 768494008713 PKC phosphorylation site [posttranslational modification]; other site 768494008714 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 768494008715 DNA polymerase IV; Reviewed; Region: PRK03103 768494008716 active site 768494008717 DNA binding site [nucleotide binding] 768494008718 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 768494008719 YolD-like protein; Region: YolD; pfam08863 768494008720 Tar ligand binding domain homologue; Region: TarH; pfam02203 768494008721 Cache domain; Region: Cache_1; pfam02743 768494008722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494008723 dimerization interface [polypeptide binding]; other site 768494008724 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768494008725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494008726 dimer interface [polypeptide binding]; other site 768494008727 putative CheW interface [polypeptide binding]; other site 768494008728 CAAX protease self-immunity; Region: Abi; pfam02517 768494008729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494008730 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494008731 Coenzyme A binding pocket [chemical binding]; other site 768494008732 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 768494008733 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 768494008734 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 768494008735 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 768494008736 FOG: PKD repeat [General function prediction only]; Region: COG3291 768494008737 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 768494008738 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 768494008739 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 768494008740 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768494008741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494008742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494008743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494008744 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494008745 dimerization interface [polypeptide binding]; other site 768494008746 putative DNA binding site [nucleotide binding]; other site 768494008747 putative Zn2+ binding site [ion binding]; other site 768494008748 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768494008749 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 768494008750 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 768494008751 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 768494008752 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 768494008753 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 768494008754 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768494008755 inhibitor-cofactor binding pocket; inhibition site 768494008756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494008757 catalytic residue [active] 768494008758 Acylphosphatase; Region: Acylphosphatase; pfam00708 768494008759 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 768494008760 HypF finger; Region: zf-HYPF; pfam07503 768494008761 HypF finger; Region: zf-HYPF; pfam07503 768494008762 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 768494008763 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 768494008764 dimerization interface [polypeptide binding]; other site 768494008765 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 768494008766 ATP binding site [chemical binding]; other site 768494008767 Isochorismatase family; Region: Isochorismatase; pfam00857 768494008768 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768494008769 catalytic triad [active] 768494008770 conserved cis-peptide bond; other site 768494008771 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 768494008772 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494008773 putative DNA binding site [nucleotide binding]; other site 768494008774 putative Zn2+ binding site [ion binding]; other site 768494008775 AsnC family; Region: AsnC_trans_reg; pfam01037 768494008776 putative transporter; Provisional; Region: PRK11021 768494008777 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 768494008778 Uncharacterized conserved protein [Function unknown]; Region: COG4198 768494008779 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 768494008780 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 768494008781 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 768494008782 putative ligand binding site [chemical binding]; other site 768494008783 putative NAD binding site [chemical binding]; other site 768494008784 putative catalytic site [active] 768494008785 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 768494008786 L-serine binding site [chemical binding]; other site 768494008787 ACT domain interface; other site 768494008788 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 768494008789 homodimer interface [polypeptide binding]; other site 768494008790 substrate-cofactor binding pocket; other site 768494008791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494008792 catalytic residue [active] 768494008793 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 768494008794 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 768494008795 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 768494008796 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494008797 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 768494008798 Domain of unknown function (DUF378); Region: DUF378; cl00943 768494008799 Cupin domain; Region: Cupin_2; cl17218 768494008800 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768494008801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494008802 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 768494008803 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 768494008804 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 768494008805 active site 768494008806 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 768494008807 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 768494008808 amidase catalytic site [active] 768494008809 Zn binding residues [ion binding]; other site 768494008810 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494008811 S-layer homology domain; Region: SLH; pfam00395 768494008812 S-layer homology domain; Region: SLH; pfam00395 768494008813 S-layer homology domain; Region: SLH; pfam00395 768494008814 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 768494008815 A new structural DNA glycosylase; Region: AlkD_like; cd06561 768494008816 active site 768494008817 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 768494008818 S-layer homology domain; Region: SLH; pfam00395 768494008819 S-layer homology domain; Region: SLH; pfam00395 768494008820 S-layer homology domain; Region: SLH; pfam00395 768494008821 potential frameshift: common BLAST hit: gi|376267172|ref|YP_005119884.1| Glyoxalase family protein 768494008822 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768494008823 active site 768494008824 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768494008825 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 768494008826 NETI protein; Region: NETI; pfam14044 768494008827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494008828 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494008829 putative substrate translocation pore; other site 768494008830 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768494008831 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768494008832 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494008833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494008834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494008835 putative substrate translocation pore; other site 768494008836 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494008837 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494008838 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 768494008839 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494008840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494008841 Walker A/P-loop; other site 768494008842 ATP binding site [chemical binding]; other site 768494008843 Q-loop/lid; other site 768494008844 ABC transporter signature motif; other site 768494008845 Walker B; other site 768494008846 D-loop; other site 768494008847 H-loop/switch region; other site 768494008848 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 768494008849 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494008850 putative DNA binding site [nucleotide binding]; other site 768494008851 putative Zn2+ binding site [ion binding]; other site 768494008852 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 768494008853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494008854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494008855 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 768494008856 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 768494008857 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 768494008858 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768494008859 SWIM zinc finger; Region: SWIM; pfam04434 768494008860 YwiC-like protein; Region: YwiC; pfam14256 768494008861 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 768494008862 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 768494008863 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 768494008864 Walker A/P-loop; other site 768494008865 ATP binding site [chemical binding]; other site 768494008866 Q-loop/lid; other site 768494008867 ABC transporter signature motif; other site 768494008868 Walker B; other site 768494008869 D-loop; other site 768494008870 H-loop/switch region; other site 768494008871 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 768494008872 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 768494008873 Walker A/P-loop; other site 768494008874 ATP binding site [chemical binding]; other site 768494008875 Q-loop/lid; other site 768494008876 ABC transporter signature motif; other site 768494008877 Walker B; other site 768494008878 D-loop; other site 768494008879 H-loop/switch region; other site 768494008880 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 768494008881 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 768494008882 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 768494008883 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 768494008884 Predicted membrane protein [Function unknown]; Region: COG1288 768494008885 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 768494008886 Endonuclease I; Region: Endonuclease_1; pfam04231 768494008887 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768494008888 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 768494008889 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494008890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494008891 non-specific DNA binding site [nucleotide binding]; other site 768494008892 salt bridge; other site 768494008893 sequence-specific DNA binding site [nucleotide binding]; other site 768494008894 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 768494008895 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 768494008896 putative deacylase active site [active] 768494008897 histidyl-tRNA synthetase; Provisional; Region: PRK12420 768494008898 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 768494008899 dimer interface [polypeptide binding]; other site 768494008900 motif 1; other site 768494008901 active site 768494008902 motif 2; other site 768494008903 motif 3; other site 768494008904 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 768494008905 anticodon binding site; other site 768494008906 Predicted transcriptional regulators [Transcription]; Region: COG1733 768494008907 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768494008908 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 768494008909 dimer interface [polypeptide binding]; other site 768494008910 FMN binding site [chemical binding]; other site 768494008911 pyruvate kinase; Validated; Region: PRK06739 768494008912 active site 768494008913 domain interfaces; other site 768494008914 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 768494008915 classical (c) SDRs; Region: SDR_c; cd05233 768494008916 NAD(P) binding site [chemical binding]; other site 768494008917 active site 768494008918 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 768494008919 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494008920 Walker A/P-loop; other site 768494008921 ATP binding site [chemical binding]; other site 768494008922 Q-loop/lid; other site 768494008923 ABC transporter signature motif; other site 768494008924 Walker B; other site 768494008925 D-loop; other site 768494008926 H-loop/switch region; other site 768494008927 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 768494008928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494008929 sequence-specific DNA binding site [nucleotide binding]; other site 768494008930 salt bridge; other site 768494008931 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 768494008932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494008933 motif II; other site 768494008934 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 768494008935 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 768494008936 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 768494008937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494008938 Coenzyme A binding pocket [chemical binding]; other site 768494008939 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 768494008940 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 768494008941 nudix motif; other site 768494008942 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 768494008943 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 768494008944 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494008945 putative metal binding site [ion binding]; other site 768494008946 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768494008947 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768494008948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494008949 putative substrate translocation pore; other site 768494008950 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494008951 maltose O-acetyltransferase; Provisional; Region: PRK10092 768494008952 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 768494008953 active site 768494008954 substrate binding site [chemical binding]; other site 768494008955 trimer interface [polypeptide binding]; other site 768494008956 CoA binding site [chemical binding]; other site 768494008957 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768494008958 FtsX-like permease family; Region: FtsX; pfam02687 768494008959 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768494008960 FtsX-like permease family; Region: FtsX; pfam02687 768494008961 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768494008962 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768494008963 Walker A/P-loop; other site 768494008964 ATP binding site [chemical binding]; other site 768494008965 Q-loop/lid; other site 768494008966 ABC transporter signature motif; other site 768494008967 Walker B; other site 768494008968 D-loop; other site 768494008969 H-loop/switch region; other site 768494008970 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 768494008971 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 768494008972 active site 768494008973 HIGH motif; other site 768494008974 dimer interface [polypeptide binding]; other site 768494008975 KMSKS motif; other site 768494008976 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 768494008977 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 768494008978 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 768494008979 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 768494008980 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768494008981 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768494008982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494008983 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768494008984 Coenzyme A binding pocket [chemical binding]; other site 768494008985 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768494008986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494008987 S-adenosylmethionine binding site [chemical binding]; other site 768494008988 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 768494008989 CGNR zinc finger; Region: zf-CGNR; pfam11706 768494008990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494008991 multidrug resistance protein MdtH; Provisional; Region: PRK11646 768494008992 putative substrate translocation pore; other site 768494008993 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768494008994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494008995 TPR motif; other site 768494008996 binding surface 768494008997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768494008998 binding surface 768494008999 TPR motif; other site 768494009000 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 768494009001 hypothetical protein; Provisional; Region: PRK04164 768494009002 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768494009003 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768494009004 Domain of unknown function DUF21; Region: DUF21; pfam01595 768494009005 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768494009006 Transporter associated domain; Region: CorC_HlyC; smart01091 768494009007 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 768494009008 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 768494009009 DNA binding residues [nucleotide binding] 768494009010 putative dimer interface [polypeptide binding]; other site 768494009011 EamA-like transporter family; Region: EamA; pfam00892 768494009012 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768494009013 EamA-like transporter family; Region: EamA; pfam00892 768494009014 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 768494009015 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 768494009016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 768494009017 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 768494009018 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 768494009019 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 768494009020 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 768494009021 N- and C-terminal domain interface [polypeptide binding]; other site 768494009022 active site 768494009023 catalytic site [active] 768494009024 metal binding site [ion binding]; metal-binding site 768494009025 carbohydrate binding site [chemical binding]; other site 768494009026 ATP binding site [chemical binding]; other site 768494009027 fructuronate transporter; Provisional; Region: PRK10034; cl15264 768494009028 GntP family permease; Region: GntP_permease; pfam02447 768494009029 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 768494009030 active site 768494009031 intersubunit interactions; other site 768494009032 catalytic residue [active] 768494009033 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 768494009034 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768494009035 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 768494009036 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768494009037 TPP-binding site [chemical binding]; other site 768494009038 dimer interface [polypeptide binding]; other site 768494009039 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768494009040 PYR/PP interface [polypeptide binding]; other site 768494009041 dimer interface [polypeptide binding]; other site 768494009042 TPP binding site [chemical binding]; other site 768494009043 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768494009044 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 768494009045 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 768494009046 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 768494009047 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 768494009048 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768494009049 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 768494009050 putative NAD(P) binding site [chemical binding]; other site 768494009051 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 768494009052 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 768494009053 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 768494009054 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768494009055 putative NAD(P) binding site [chemical binding]; other site 768494009056 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768494009057 classical (c) SDRs; Region: SDR_c; cd05233 768494009058 NAD(P) binding site [chemical binding]; other site 768494009059 active site 768494009060 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 768494009061 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 768494009062 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 768494009063 active site 768494009064 Zn binding site [ion binding]; other site 768494009065 Viral enhancin protein; Region: Enhancin; pfam03272 768494009066 Peptidase M60-like family; Region: M60-like; pfam13402 768494009067 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 768494009068 dimer interface [polypeptide binding]; other site 768494009069 FMN binding site [chemical binding]; other site 768494009070 BNR repeat-like domain; Region: BNR_2; pfam13088 768494009071 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768494009072 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768494009073 active site 768494009074 catalytic tetrad [active] 768494009075 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768494009076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494009077 putative substrate translocation pore; other site 768494009078 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768494009079 active site 1 [active] 768494009080 dimer interface [polypeptide binding]; other site 768494009081 hexamer interface [polypeptide binding]; other site 768494009082 active site 2 [active] 768494009083 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 768494009084 hexamer interface [polypeptide binding]; other site 768494009085 active site 2 [active] 768494009086 hypothetical protein; Provisional; Region: PRK02487 768494009087 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494009088 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768494009089 active site 768494009090 metal binding site [ion binding]; metal-binding site 768494009091 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 768494009092 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 768494009093 IDEAL domain; Region: IDEAL; pfam08858 768494009094 Predicted transcriptional regulator [Transcription]; Region: COG1959 768494009095 Transcriptional regulator; Region: Rrf2; pfam02082 768494009096 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 768494009097 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 768494009098 ArsC family; Region: ArsC; pfam03960 768494009099 putative catalytic residues [active] 768494009100 thiol/disulfide switch; other site 768494009101 Predicted transcriptional regulators [Transcription]; Region: COG1733 768494009102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494009103 dimerization interface [polypeptide binding]; other site 768494009104 putative DNA binding site [nucleotide binding]; other site 768494009105 putative Zn2+ binding site [ion binding]; other site 768494009106 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768494009107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494009108 DNA-binding site [nucleotide binding]; DNA binding site 768494009109 UTRA domain; Region: UTRA; pfam07702 768494009110 putative oxidoreductase; Provisional; Region: PRK10206 768494009111 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768494009112 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768494009113 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 768494009114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768494009115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494009116 S-adenosylmethionine binding site [chemical binding]; other site 768494009117 Predicted transcriptional regulators [Transcription]; Region: COG1733 768494009118 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768494009119 Predicted transcriptional regulators [Transcription]; Region: COG1733 768494009120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494009121 dimerization interface [polypeptide binding]; other site 768494009122 putative DNA binding site [nucleotide binding]; other site 768494009123 putative Zn2+ binding site [ion binding]; other site 768494009124 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768494009125 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768494009126 active site 768494009127 catalytic tetrad [active] 768494009128 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 768494009129 putative hydrophobic ligand binding site [chemical binding]; other site 768494009130 protein interface [polypeptide binding]; other site 768494009131 gate; other site 768494009132 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494009133 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 768494009134 active site 768494009135 ATP binding site [chemical binding]; other site 768494009136 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 768494009137 Phosphotransferase enzyme family; Region: APH; pfam01636 768494009138 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 768494009139 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768494009140 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768494009141 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494009142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494009143 Coenzyme A binding pocket [chemical binding]; other site 768494009144 C factor cell-cell signaling protein; Provisional; Region: PRK09009 768494009145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494009146 NAD(P) binding site [chemical binding]; other site 768494009147 active site 768494009148 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494009149 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494009150 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 768494009151 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768494009152 acyl-activating enzyme (AAE) consensus motif; other site 768494009153 AMP binding site [chemical binding]; other site 768494009154 active site 768494009155 CoA binding site [chemical binding]; other site 768494009156 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 768494009157 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 768494009158 Predicted transcriptional regulators [Transcription]; Region: COG1733 768494009159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494009160 dimerization interface [polypeptide binding]; other site 768494009161 putative DNA binding site [nucleotide binding]; other site 768494009162 putative Zn2+ binding site [ion binding]; other site 768494009163 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 768494009164 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 768494009165 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768494009166 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 768494009167 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768494009168 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494009169 dimerization interface [polypeptide binding]; other site 768494009170 putative DNA binding site [nucleotide binding]; other site 768494009171 putative Zn2+ binding site [ion binding]; other site 768494009172 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 768494009173 active site 768494009174 Glyco_18 domain; Region: Glyco_18; smart00636 768494009175 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 768494009176 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 768494009177 NodB motif; other site 768494009178 putative active site [active] 768494009179 putative catalytic site [active] 768494009180 putative Zn binding site [ion binding]; other site 768494009181 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 768494009182 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 768494009183 DXD motif; other site 768494009184 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 768494009185 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 768494009186 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494009187 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494009188 active site 768494009189 CAAX protease self-immunity; Region: Abi; pfam02517 768494009190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494009191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494009192 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 768494009193 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 768494009194 Predicted transcriptional regulator [Transcription]; Region: COG2378 768494009195 HTH domain; Region: HTH_11; pfam08279 768494009196 Protein of unknown function (DUF805); Region: DUF805; pfam05656 768494009197 ABC-2 type transporter; Region: ABC2_membrane; cl17235 768494009198 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 768494009199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494009200 Walker A/P-loop; other site 768494009201 ATP binding site [chemical binding]; other site 768494009202 Q-loop/lid; other site 768494009203 ABC transporter signature motif; other site 768494009204 Walker B; other site 768494009205 D-loop; other site 768494009206 H-loop/switch region; other site 768494009207 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 768494009208 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494009209 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768494009210 hydroxylamine reductase; Provisional; Region: PRK12310 768494009211 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768494009212 ACS interaction site; other site 768494009213 CODH interaction site; other site 768494009214 metal cluster binding site [ion binding]; other site 768494009215 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494009216 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 768494009217 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 768494009218 active site 768494009219 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 768494009220 metal binding site [ion binding]; metal-binding site 768494009221 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 768494009222 hypothetical protein; Provisional; Region: PRK06771 768494009223 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494009224 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494009225 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 768494009226 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 768494009227 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 768494009228 dimer interface [polypeptide binding]; other site 768494009229 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494009230 ligand binding site [chemical binding]; other site 768494009231 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 768494009232 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768494009233 ligand binding site [chemical binding]; other site 768494009234 flexible hinge region; other site 768494009235 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 768494009236 Protein of unknown function, DUF606; Region: DUF606; pfam04657 768494009237 Protein of unknown function, DUF606; Region: DUF606; pfam04657 768494009238 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494009239 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 768494009240 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 768494009241 putative NAD(P) binding site [chemical binding]; other site 768494009242 dimer interface [polypeptide binding]; other site 768494009243 putative transport protein YifK; Provisional; Region: PRK10746 768494009244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494009245 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 768494009246 putative substrate translocation pore; other site 768494009247 Haemolysin XhlA; Region: XhlA; pfam10779 768494009248 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 768494009249 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 768494009250 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 768494009251 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 768494009252 transmembrane helices; other site 768494009253 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494009254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494009255 Coenzyme A binding pocket [chemical binding]; other site 768494009256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494009257 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 768494009258 putative ligand binding residues [chemical binding]; other site 768494009259 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768494009260 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768494009261 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768494009262 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494009263 ABC-ATPase subunit interface; other site 768494009264 dimer interface [polypeptide binding]; other site 768494009265 putative PBP binding regions; other site 768494009266 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768494009267 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494009268 ABC-ATPase subunit interface; other site 768494009269 dimer interface [polypeptide binding]; other site 768494009270 putative PBP binding regions; other site 768494009271 Protein of unknown function (DUF817); Region: DUF817; pfam05675 768494009272 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 768494009273 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768494009274 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 768494009275 DinB superfamily; Region: DinB_2; pfam12867 768494009276 DinB family; Region: DinB; cl17821 768494009277 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 768494009278 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 768494009279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768494009280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494009281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768494009282 dimerization interface [polypeptide binding]; other site 768494009283 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768494009284 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 768494009285 NADP binding site [chemical binding]; other site 768494009286 dimer interface [polypeptide binding]; other site 768494009287 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768494009288 catalytic core [active] 768494009289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494009290 Coenzyme A binding pocket [chemical binding]; other site 768494009291 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 768494009292 MutS domain III; Region: MutS_III; pfam05192 768494009293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494009294 Walker A/P-loop; other site 768494009295 ATP binding site [chemical binding]; other site 768494009296 Q-loop/lid; other site 768494009297 ABC transporter signature motif; other site 768494009298 Walker B; other site 768494009299 D-loop; other site 768494009300 H-loop/switch region; other site 768494009301 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 768494009302 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 768494009303 active site 768494009304 Na/Ca binding site [ion binding]; other site 768494009305 catalytic site [active] 768494009306 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 768494009307 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 768494009308 oligoendopeptidase F; Region: pepF; TIGR00181 768494009309 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 768494009310 active site 768494009311 Zn binding site [ion binding]; other site 768494009312 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 768494009313 Beta-lactamase; Region: Beta-lactamase; pfam00144 768494009314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494009315 putative substrate translocation pore; other site 768494009316 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494009317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768494009318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494009319 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 768494009320 putative dimerization interface [polypeptide binding]; other site 768494009321 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 768494009322 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768494009323 putative active site [active] 768494009324 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 768494009325 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768494009326 active site 768494009327 catalytic site [active] 768494009328 metal binding site [ion binding]; metal-binding site 768494009329 FAD binding domain; Region: FAD_binding_3; pfam01494 768494009330 hypothetical protein; Provisional; Region: PRK07236 768494009331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494009332 dimerization interface [polypeptide binding]; other site 768494009333 putative DNA binding site [nucleotide binding]; other site 768494009334 putative Zn2+ binding site [ion binding]; other site 768494009335 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768494009336 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 768494009337 putative NAD(P) binding site [chemical binding]; other site 768494009338 Uncharacterized conserved protein [Function unknown]; Region: COG0397 768494009339 hypothetical protein; Validated; Region: PRK00029 768494009340 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768494009341 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 768494009342 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 768494009343 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768494009344 Sodium Bile acid symporter family; Region: SBF; cl17470 768494009345 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 768494009346 FAD binding domain; Region: FAD_binding_4; pfam01565 768494009347 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 768494009348 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768494009349 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768494009350 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 768494009351 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 768494009352 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 768494009353 trimer interface [polypeptide binding]; other site 768494009354 active site 768494009355 substrate binding site [chemical binding]; other site 768494009356 CoA binding site [chemical binding]; other site 768494009357 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768494009358 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768494009359 inhibitor-cofactor binding pocket; inhibition site 768494009360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494009361 catalytic residue [active] 768494009362 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768494009363 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 768494009364 active site 768494009365 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768494009366 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768494009367 active site 768494009368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494009369 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768494009370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 768494009371 enoyl-CoA hydratase; Provisional; Region: PRK06688 768494009372 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768494009373 substrate binding site [chemical binding]; other site 768494009374 oxyanion hole (OAH) forming residues; other site 768494009375 trimer interface [polypeptide binding]; other site 768494009376 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 768494009377 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 768494009378 FOG: PKD repeat [General function prediction only]; Region: COG3291 768494009379 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 768494009380 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 768494009381 MgtC family; Region: MgtC; pfam02308 768494009382 Predicted acetyltransferase [General function prediction only]; Region: COG3981 768494009383 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494009384 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 768494009385 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 768494009386 putative metal binding site [ion binding]; other site 768494009387 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768494009388 active site 768494009389 metal binding site [ion binding]; metal-binding site 768494009390 VanW like protein; Region: VanW; pfam04294 768494009391 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 768494009392 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 768494009393 exonuclease; Provisional; Region: PRK06722 768494009394 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 768494009395 active site 768494009396 catalytic site [active] 768494009397 substrate binding site [chemical binding]; other site 768494009398 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768494009399 DNA-binding site [nucleotide binding]; DNA binding site 768494009400 RNA-binding motif; other site 768494009401 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 768494009402 flavodoxin; Provisional; Region: PRK06703 768494009403 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 768494009404 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 768494009405 nudix motif; other site 768494009406 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 768494009407 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 768494009408 trimer interface [polypeptide binding]; other site 768494009409 active site 768494009410 substrate binding site [chemical binding]; other site 768494009411 CoA binding site [chemical binding]; other site 768494009412 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009413 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009414 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009415 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009416 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009417 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009418 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009419 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009420 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009421 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009422 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009423 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009424 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009425 short chain dehydrogenase; Provisional; Region: PRK06924 768494009426 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 768494009427 NADP binding site [chemical binding]; other site 768494009428 homodimer interface [polypeptide binding]; other site 768494009429 active site 768494009430 Predicted acetyltransferase [General function prediction only]; Region: COG3393 768494009431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494009432 argininosuccinate lyase; Provisional; Region: PRK06705 768494009433 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 768494009434 active sites [active] 768494009435 tetramer interface [polypeptide binding]; other site 768494009436 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768494009437 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768494009438 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 768494009439 active site 768494009440 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768494009441 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 768494009442 Na binding site [ion binding]; other site 768494009443 Protein of unknown function (DUF997); Region: DUF997; pfam06196 768494009444 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 768494009445 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768494009446 NAD(P) binding site [chemical binding]; other site 768494009447 catalytic residues [active] 768494009448 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768494009449 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768494009450 NAD(P) binding site [chemical binding]; other site 768494009451 homotetramer interface [polypeptide binding]; other site 768494009452 homodimer interface [polypeptide binding]; other site 768494009453 active site 768494009454 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 768494009455 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 768494009456 Divergent PAP2 family; Region: DUF212; pfam02681 768494009457 Predicted permeases [General function prediction only]; Region: RarD; COG2962 768494009458 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 768494009459 antiporter inner membrane protein; Provisional; Region: PRK11670 768494009460 Domain of unknown function DUF59; Region: DUF59; pfam01883 768494009461 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 768494009462 Walker A motif; other site 768494009463 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 768494009464 MoaE interaction surface [polypeptide binding]; other site 768494009465 MoeB interaction surface [polypeptide binding]; other site 768494009466 thiocarboxylated glycine; other site 768494009467 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 768494009468 MoaE homodimer interface [polypeptide binding]; other site 768494009469 MoaD interaction [polypeptide binding]; other site 768494009470 active site residues [active] 768494009471 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 768494009472 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 768494009473 dimer interface [polypeptide binding]; other site 768494009474 putative functional site; other site 768494009475 putative MPT binding site; other site 768494009476 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 768494009477 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768494009478 ATP binding site [chemical binding]; other site 768494009479 substrate interface [chemical binding]; other site 768494009480 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 768494009481 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 768494009482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494009483 FeS/SAM binding site; other site 768494009484 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768494009485 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 768494009486 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 768494009487 Uncharacterized conserved protein [Function unknown]; Region: COG5609 768494009488 Uncharacterized conserved protein [Function unknown]; Region: COG2427 768494009489 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 768494009490 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 768494009491 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 768494009492 4Fe-4S binding domain; Region: Fer4; pfam00037 768494009493 4Fe-4S binding domain; Region: Fer4; pfam00037 768494009494 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 768494009495 [4Fe-4S] binding site [ion binding]; other site 768494009496 molybdopterin cofactor binding site; other site 768494009497 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 768494009498 molybdopterin cofactor binding site; other site 768494009499 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 768494009500 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 768494009501 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 768494009502 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 768494009503 Tubulin like; Region: Tubulin_2; pfam13809 768494009504 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 768494009505 metal ion-dependent adhesion site (MIDAS); other site 768494009506 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768494009507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494009508 S-adenosylmethionine binding site [chemical binding]; other site 768494009509 O-methyltransferase; Region: Methyltransf_2; pfam00891 768494009510 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768494009511 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494009512 peptide binding site [polypeptide binding]; other site 768494009513 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768494009514 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494009515 peptide binding site [polypeptide binding]; other site 768494009516 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768494009517 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768494009518 peptide binding site [polypeptide binding]; other site 768494009519 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 768494009520 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768494009521 Transcriptional regulator [Transcription]; Region: LytR; COG1316 768494009522 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 768494009523 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494009524 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494009525 DNA binding residues [nucleotide binding] 768494009526 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768494009527 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768494009528 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494009529 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494009530 Walker A/P-loop; other site 768494009531 ATP binding site [chemical binding]; other site 768494009532 Q-loop/lid; other site 768494009533 ABC transporter signature motif; other site 768494009534 Walker B; other site 768494009535 D-loop; other site 768494009536 H-loop/switch region; other site 768494009537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494009538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494009539 putative oxidoreductase; Provisional; Region: PRK11579 768494009540 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768494009541 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768494009542 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 768494009543 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768494009544 CAP-like domain; other site 768494009545 active site 768494009546 primary dimer interface [polypeptide binding]; other site 768494009547 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768494009548 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768494009549 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768494009550 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768494009551 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 768494009552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494009553 ATP binding site [chemical binding]; other site 768494009554 Mg2+ binding site [ion binding]; other site 768494009555 G-X-G motif; other site 768494009556 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768494009557 anchoring element; other site 768494009558 dimer interface [polypeptide binding]; other site 768494009559 ATP binding site [chemical binding]; other site 768494009560 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 768494009561 active site 768494009562 putative metal-binding site [ion binding]; other site 768494009563 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768494009564 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 768494009565 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768494009566 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768494009567 protein binding site [polypeptide binding]; other site 768494009568 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494009569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494009570 active site 768494009571 phosphorylation site [posttranslational modification] 768494009572 intermolecular recognition site; other site 768494009573 dimerization interface [polypeptide binding]; other site 768494009574 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494009575 DNA binding site [nucleotide binding] 768494009576 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 768494009577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494009578 FeS/SAM binding site; other site 768494009579 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 768494009580 Class III ribonucleotide reductase; Region: RNR_III; cd01675 768494009581 effector binding site; other site 768494009582 active site 768494009583 Zn binding site [ion binding]; other site 768494009584 glycine loop; other site 768494009585 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 768494009586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 768494009587 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768494009588 active site 768494009589 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 768494009590 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768494009591 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768494009592 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 768494009593 active site 768494009594 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 768494009595 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 768494009596 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 768494009597 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 768494009598 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768494009599 active site 768494009600 catalytic site [active] 768494009601 substrate binding site [chemical binding]; other site 768494009602 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 768494009603 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768494009604 catalytic residues [active] 768494009605 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768494009606 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494009607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494009608 Walker A/P-loop; other site 768494009609 ATP binding site [chemical binding]; other site 768494009610 ABC transporter signature motif; other site 768494009611 Walker B; other site 768494009612 D-loop; other site 768494009613 H-loop/switch region; other site 768494009614 aconitate hydratase; Validated; Region: PRK09277 768494009615 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 768494009616 substrate binding site [chemical binding]; other site 768494009617 ligand binding site [chemical binding]; other site 768494009618 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 768494009619 substrate binding site [chemical binding]; other site 768494009620 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 768494009621 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 768494009622 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 768494009623 NodB motif; other site 768494009624 active site 768494009625 catalytic site [active] 768494009626 metal binding site [ion binding]; metal-binding site 768494009627 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768494009628 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 768494009629 putative dimer interface [polypeptide binding]; other site 768494009630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 768494009631 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 768494009632 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768494009633 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 768494009634 nudix motif; other site 768494009635 SAP domain; Region: SAP; pfam02037 768494009636 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 768494009637 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768494009638 dimer interface [polypeptide binding]; other site 768494009639 active site 768494009640 acyl-CoA synthetase; Validated; Region: PRK07638 768494009641 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768494009642 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768494009643 acyl-activating enzyme (AAE) consensus motif; other site 768494009644 acyl-activating enzyme (AAE) consensus motif; other site 768494009645 AMP binding site [chemical binding]; other site 768494009646 active site 768494009647 CoA binding site [chemical binding]; other site 768494009648 BioY family; Region: BioY; pfam02632 768494009649 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 768494009650 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 768494009651 dimer interface [polypeptide binding]; other site 768494009652 acyl-activating enzyme (AAE) consensus motif; other site 768494009653 putative active site [active] 768494009654 AMP binding site [chemical binding]; other site 768494009655 putative CoA binding site [chemical binding]; other site 768494009656 S-layer homology domain; Region: SLH; pfam00395 768494009657 S-layer homology domain; Region: SLH; pfam00395 768494009658 S-layer homology domain; Region: SLH; pfam00395 768494009659 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768494009660 active site 768494009661 catalytic motif [active] 768494009662 Zn binding site [ion binding]; other site 768494009663 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 768494009664 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768494009665 amidase catalytic site [active] 768494009666 Zn binding residues [ion binding]; other site 768494009667 substrate binding site [chemical binding]; other site 768494009668 active site 768494009669 Protein phosphatase 2C; Region: PP2C_2; pfam13672 768494009670 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768494009671 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768494009672 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494009673 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 768494009674 dimer interface [polypeptide binding]; other site 768494009675 putative metal binding site [ion binding]; other site 768494009676 PAS domain S-box; Region: sensory_box; TIGR00229 768494009677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494009678 putative active site [active] 768494009679 heme pocket [chemical binding]; other site 768494009680 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 768494009681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494009682 putative active site [active] 768494009683 heme pocket [chemical binding]; other site 768494009684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494009685 dimer interface [polypeptide binding]; other site 768494009686 phosphorylation site [posttranslational modification] 768494009687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494009688 ATP binding site [chemical binding]; other site 768494009689 Mg2+ binding site [ion binding]; other site 768494009690 G-X-G motif; other site 768494009691 Predicted esterase [General function prediction only]; Region: COG0400 768494009692 putative hydrolase; Provisional; Region: PRK11460 768494009693 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 768494009694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494009695 Zn binding site [ion binding]; other site 768494009696 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 768494009697 Zn binding site [ion binding]; other site 768494009698 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 768494009699 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768494009700 Na binding site [ion binding]; other site 768494009701 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 768494009702 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768494009703 active site 768494009704 FMN binding site [chemical binding]; other site 768494009705 substrate binding site [chemical binding]; other site 768494009706 3Fe-4S cluster binding site [ion binding]; other site 768494009707 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768494009708 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 768494009709 FMN binding site [chemical binding]; other site 768494009710 active site 768494009711 substrate binding site [chemical binding]; other site 768494009712 catalytic residue [active] 768494009713 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 768494009714 agmatinase; Region: agmatinase; TIGR01230 768494009715 Agmatinase-like family; Region: Agmatinase-like; cd09990 768494009716 active site 768494009717 oligomer interface [polypeptide binding]; other site 768494009718 Mn binding site [ion binding]; other site 768494009719 imidazolonepropionase; Validated; Region: PRK09356 768494009720 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 768494009721 active site 768494009722 urocanate hydratase; Provisional; Region: PRK05414 768494009723 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 768494009724 active sites [active] 768494009725 tetramer interface [polypeptide binding]; other site 768494009726 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 768494009727 hexamer interface [polypeptide binding]; other site 768494009728 RNA binding site [nucleotide binding]; other site 768494009729 Histidine-zinc binding site [chemical binding]; other site 768494009730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494009731 S-adenosylmethionine binding site [chemical binding]; other site 768494009732 DJ-1 family protein; Region: not_thiJ; TIGR01383 768494009733 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 768494009734 conserved cys residue [active] 768494009735 AAA domain; Region: AAA_28; pfam13521 768494009736 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 768494009737 active site 768494009738 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 768494009739 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009740 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009741 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009742 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009743 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009744 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009745 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009746 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009747 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009748 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009749 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009750 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009751 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009752 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009753 conserved repeat domain; Region: B_ant_repeat; TIGR01451 768494009754 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 768494009755 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 768494009756 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 768494009757 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 768494009758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494009759 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 768494009760 putative dimerization interface [polypeptide binding]; other site 768494009761 putative substrate binding pocket [chemical binding]; other site 768494009762 holin-like protein; Validated; Region: PRK01658 768494009763 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 768494009764 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 768494009765 nudix motif; other site 768494009766 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 768494009767 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768494009768 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768494009769 amidase catalytic site [active] 768494009770 Zn binding residues [ion binding]; other site 768494009771 substrate binding site [chemical binding]; other site 768494009772 S-layer homology domain; Region: SLH; pfam00395 768494009773 S-layer homology domain; Region: SLH; pfam00395 768494009774 S-layer homology domain; Region: SLH; pfam00395 768494009775 Nuclease-related domain; Region: NERD; pfam08378 768494009776 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768494009777 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494009778 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 768494009779 Walker A/P-loop; other site 768494009780 ATP binding site [chemical binding]; other site 768494009781 Q-loop/lid; other site 768494009782 ABC transporter signature motif; other site 768494009783 Walker B; other site 768494009784 D-loop; other site 768494009785 H-loop/switch region; other site 768494009786 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494009787 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 768494009788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494009789 Walker A/P-loop; other site 768494009790 ATP binding site [chemical binding]; other site 768494009791 Q-loop/lid; other site 768494009792 ABC transporter signature motif; other site 768494009793 Walker B; other site 768494009794 D-loop; other site 768494009795 H-loop/switch region; other site 768494009796 hypothetical protein; Provisional; Region: PRK01844 768494009797 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 768494009798 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 768494009799 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768494009800 TPP-binding site [chemical binding]; other site 768494009801 dimer interface [polypeptide binding]; other site 768494009802 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768494009803 PYR/PP interface [polypeptide binding]; other site 768494009804 dimer interface [polypeptide binding]; other site 768494009805 TPP binding site [chemical binding]; other site 768494009806 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768494009807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 768494009808 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 768494009809 Probable transposase; Region: OrfB_IS605; pfam01385 768494009810 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768494009811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494009812 dimer interface [polypeptide binding]; other site 768494009813 conserved gate region; other site 768494009814 ABC-ATPase subunit interface; other site 768494009815 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768494009816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494009817 dimer interface [polypeptide binding]; other site 768494009818 conserved gate region; other site 768494009819 ABC-ATPase subunit interface; other site 768494009820 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 768494009821 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 768494009822 Walker A/P-loop; other site 768494009823 ATP binding site [chemical binding]; other site 768494009824 Q-loop/lid; other site 768494009825 ABC transporter signature motif; other site 768494009826 Walker B; other site 768494009827 D-loop; other site 768494009828 H-loop/switch region; other site 768494009829 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 768494009830 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768494009831 membrane-bound complex binding site; other site 768494009832 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 768494009833 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768494009834 active site 768494009835 metal binding site [ion binding]; metal-binding site 768494009836 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768494009837 hypothetical protein; Provisional; Region: PRK01546 768494009838 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 768494009839 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 768494009840 catalytic residues [active] 768494009841 catalytic nucleophile [active] 768494009842 LexA repressor; Validated; Region: PRK00215 768494009843 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494009844 putative DNA binding site [nucleotide binding]; other site 768494009845 putative Zn2+ binding site [ion binding]; other site 768494009846 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768494009847 Catalytic site [active] 768494009848 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 768494009849 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 768494009850 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 768494009851 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494009852 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768494009853 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768494009854 Helix-turn-helix domain; Region: HTH_17; pfam12728 768494009855 Helix-turn-helix domain; Region: HTH_17; pfam12728 768494009856 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768494009857 amidase catalytic site [active] 768494009858 Zn binding residues [ion binding]; other site 768494009859 substrate binding site [chemical binding]; other site 768494009860 Bacterial SH3 domain; Region: SH3_3; cl17532 768494009861 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494009862 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 768494009863 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 768494009864 gp58-like protein; Region: Gp58; pfam07902 768494009865 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 768494009866 Phage tail protein; Region: Sipho_tail; cl17486 768494009867 putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633 768494009868 Phage-related protein [Function unknown]; Region: COG5412 768494009869 membrane protein P6; Region: PHA01399 768494009870 Phage-related minor tail protein [Function unknown]; Region: COG5280 768494009871 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 768494009872 DsrH like protein; Region: DsrH; cl17347 768494009873 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 768494009874 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 768494009875 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 768494009876 Phage capsid family; Region: Phage_capsid; pfam05065 768494009877 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 768494009878 Phage-related protein [Function unknown]; Region: COG4695; cl01923 768494009879 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 768494009880 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 768494009881 Helix-turn-helix domain; Region: HTH_17; pfam12728 768494009882 HNH endonuclease; Region: HNH_2; pfam13391 768494009883 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 768494009884 homodimer interface [polypeptide binding]; other site 768494009885 chemical substrate binding site [chemical binding]; other site 768494009886 oligomer interface [polypeptide binding]; other site 768494009887 metal binding site [ion binding]; metal-binding site 768494009888 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 768494009889 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 768494009890 active site 768494009891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494009892 sequence-specific DNA binding site [nucleotide binding]; other site 768494009893 salt bridge; other site 768494009894 AIPR protein; Region: AIPR; pfam10592 768494009895 positive control sigma-like factor; Validated; Region: PRK06930 768494009896 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494009897 DNA binding residues [nucleotide binding] 768494009898 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 768494009899 PGAP1-like protein; Region: PGAP1; pfam07819 768494009900 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 768494009901 thymidylate synthase, flavin-dependent; Region: thyX; TIGR02170 768494009902 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768494009903 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768494009904 cofactor binding site; other site 768494009905 DNA binding site [nucleotide binding] 768494009906 substrate interaction site [chemical binding]; other site 768494009907 dUTPase; Region: dUTPase_2; pfam08761 768494009908 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 768494009909 active site 768494009910 homodimer interface [polypeptide binding]; other site 768494009911 metal binding site [ion binding]; metal-binding site 768494009912 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 768494009913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494009914 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 768494009915 Walker A motif; other site 768494009916 ATP binding site [chemical binding]; other site 768494009917 Walker B motif; other site 768494009918 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 768494009919 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 768494009920 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 768494009921 Domain of unknown function (DUF771); Region: DUF771; pfam05595 768494009922 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 768494009923 ORF6C domain; Region: ORF6C; pfam10552 768494009924 Domain of unknown function (DUF955); Region: DUF955; cl01076 768494009925 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 768494009926 Int/Topo IB signature motif; other site 768494009927 glutamine synthetase, type I; Region: GlnA; TIGR00653 768494009928 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 768494009929 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768494009930 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 768494009931 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768494009932 DNA binding residues [nucleotide binding] 768494009933 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 768494009934 Aluminium resistance protein; Region: Alum_res; pfam06838 768494009935 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 768494009936 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 768494009937 HflX GTPase family; Region: HflX; cd01878 768494009938 G1 box; other site 768494009939 GTP/Mg2+ binding site [chemical binding]; other site 768494009940 Switch I region; other site 768494009941 G2 box; other site 768494009942 G3 box; other site 768494009943 Switch II region; other site 768494009944 G4 box; other site 768494009945 G5 box; other site 768494009946 Predicted membrane protein [Function unknown]; Region: COG2860 768494009947 UPF0126 domain; Region: UPF0126; pfam03458 768494009948 UPF0126 domain; Region: UPF0126; pfam03458 768494009949 stage V sporulation protein K; Region: spore_V_K; TIGR02881 768494009950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494009951 Walker A motif; other site 768494009952 ATP binding site [chemical binding]; other site 768494009953 Walker B motif; other site 768494009954 arginine finger; other site 768494009955 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 768494009956 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 768494009957 active site 768494009958 catalytic residues [active] 768494009959 DNA binding site [nucleotide binding] 768494009960 Int/Topo IB signature motif; other site 768494009961 bacterial Hfq-like; Region: Hfq; cd01716 768494009962 hexamer interface [polypeptide binding]; other site 768494009963 Sm1 motif; other site 768494009964 RNA binding site [nucleotide binding]; other site 768494009965 Sm2 motif; other site 768494009966 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 768494009967 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 768494009968 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494009969 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494009970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 768494009971 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 768494009972 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768494009973 active site 768494009974 phosphorylation site [posttranslational modification] 768494009975 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768494009976 active site 768494009977 P-loop; other site 768494009978 phosphorylation site [posttranslational modification] 768494009979 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 768494009980 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 768494009981 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 768494009982 putative substrate binding site [chemical binding]; other site 768494009983 putative ATP binding site [chemical binding]; other site 768494009984 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 768494009985 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 768494009986 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768494009987 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 768494009988 active site 768494009989 metal binding site [ion binding]; metal-binding site 768494009990 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 768494009991 Predicted membrane protein [Function unknown]; Region: COG2322 768494009992 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 768494009993 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 768494009994 Glyco_18 domain; Region: Glyco_18; smart00636 768494009995 putative active site [active] 768494009996 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 768494009997 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 768494009998 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768494009999 putative active site [active] 768494010000 putative metal binding site [ion binding]; other site 768494010001 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 768494010002 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768494010003 IHF dimer interface [polypeptide binding]; other site 768494010004 IHF - DNA interface [nucleotide binding]; other site 768494010005 potential frameshift: common BLAST hit: gi|227813370|ref|YP_002813379.1| heavy metal-transporting ATPase 768494010006 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 768494010007 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768494010008 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 768494010009 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768494010010 metal-binding site [ion binding] 768494010011 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 768494010012 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768494010013 metal-binding site [ion binding] 768494010014 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768494010015 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 768494010016 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768494010017 metal-binding site [ion binding] 768494010018 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 768494010019 putative homodimer interface [polypeptide binding]; other site 768494010020 putative homotetramer interface [polypeptide binding]; other site 768494010021 putative allosteric switch controlling residues; other site 768494010022 putative metal binding site [ion binding]; other site 768494010023 putative homodimer-homodimer interface [polypeptide binding]; other site 768494010024 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 768494010025 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768494010026 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768494010027 Walker A/P-loop; other site 768494010028 ATP binding site [chemical binding]; other site 768494010029 Q-loop/lid; other site 768494010030 ABC transporter signature motif; other site 768494010031 Walker B; other site 768494010032 D-loop; other site 768494010033 H-loop/switch region; other site 768494010034 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768494010035 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494010036 ABC-ATPase subunit interface; other site 768494010037 dimer interface [polypeptide binding]; other site 768494010038 putative PBP binding regions; other site 768494010039 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768494010040 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494010041 ABC-ATPase subunit interface; other site 768494010042 dimer interface [polypeptide binding]; other site 768494010043 putative PBP binding regions; other site 768494010044 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 768494010045 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768494010046 putative ligand binding residues [chemical binding]; other site 768494010047 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 768494010048 active site 768494010049 putative catalytic site [active] 768494010050 DNA binding site [nucleotide binding] 768494010051 putative phosphate binding site [ion binding]; other site 768494010052 metal binding site A [ion binding]; metal-binding site 768494010053 AP binding site [nucleotide binding]; other site 768494010054 metal binding site B [ion binding]; metal-binding site 768494010055 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 768494010056 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 768494010057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494010058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494010059 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 768494010060 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768494010061 DNA binding site [nucleotide binding] 768494010062 active site 768494010063 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 768494010064 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768494010065 endonuclease III; Region: ENDO3c; smart00478 768494010066 minor groove reading motif; other site 768494010067 helix-hairpin-helix signature motif; other site 768494010068 substrate binding pocket [chemical binding]; other site 768494010069 active site 768494010070 peptidase T; Region: peptidase-T; TIGR01882 768494010071 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 768494010072 metal binding site [ion binding]; metal-binding site 768494010073 dimer interface [polypeptide binding]; other site 768494010074 Predicted membrane protein [Function unknown]; Region: COG2364 768494010075 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494010076 hypothetical protein; Provisional; Region: PRK06764 768494010077 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768494010078 catalytic core [active] 768494010079 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 768494010080 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494010081 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768494010082 active site 768494010083 PAS domain S-box; Region: sensory_box; TIGR00229 768494010084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494010085 putative active site [active] 768494010086 heme pocket [chemical binding]; other site 768494010087 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768494010088 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768494010089 metal binding site [ion binding]; metal-binding site 768494010090 active site 768494010091 I-site; other site 768494010092 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768494010093 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 768494010094 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 768494010095 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 768494010096 holin-like protein; Validated; Region: PRK01658 768494010097 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768494010098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494010099 DNA-binding site [nucleotide binding]; DNA binding site 768494010100 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494010101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494010102 homodimer interface [polypeptide binding]; other site 768494010103 catalytic residue [active] 768494010104 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768494010105 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 768494010106 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 768494010107 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 768494010108 active site 768494010109 catalytic site [active] 768494010110 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 768494010111 putative active site [active] 768494010112 putative catalytic triad [active] 768494010113 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 768494010114 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768494010115 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 768494010116 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768494010117 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 768494010118 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 768494010119 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768494010120 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 768494010121 Sulfatase; Region: Sulfatase; pfam00884 768494010122 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768494010123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494010124 binding surface 768494010125 TPR motif; other site 768494010126 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 768494010127 G1 box; other site 768494010128 GTP/Mg2+ binding site [chemical binding]; other site 768494010129 Switch I region; other site 768494010130 G3 box; other site 768494010131 Switch II region; other site 768494010132 G4 box; other site 768494010133 G5 box; other site 768494010134 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 768494010135 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 768494010136 active site 768494010137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494010138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494010139 dimer interface [polypeptide binding]; other site 768494010140 phosphorylation site [posttranslational modification] 768494010141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494010142 ATP binding site [chemical binding]; other site 768494010143 Mg2+ binding site [ion binding]; other site 768494010144 G-X-G motif; other site 768494010145 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494010146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494010147 active site 768494010148 phosphorylation site [posttranslational modification] 768494010149 intermolecular recognition site; other site 768494010150 dimerization interface [polypeptide binding]; other site 768494010151 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494010152 DNA binding site [nucleotide binding] 768494010153 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 768494010154 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 768494010155 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 768494010156 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 768494010157 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 768494010158 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 768494010159 Walker A/P-loop; other site 768494010160 ATP binding site [chemical binding]; other site 768494010161 Q-loop/lid; other site 768494010162 ABC transporter signature motif; other site 768494010163 Walker B; other site 768494010164 D-loop; other site 768494010165 H-loop/switch region; other site 768494010166 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 768494010167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494010168 ATP binding site [chemical binding]; other site 768494010169 Mg2+ binding site [ion binding]; other site 768494010170 G-X-G motif; other site 768494010171 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 768494010172 ATP binding site [chemical binding]; other site 768494010173 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 768494010174 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 768494010175 MutS domain I; Region: MutS_I; pfam01624 768494010176 MutS domain II; Region: MutS_II; pfam05188 768494010177 MutS domain III; Region: MutS_III; pfam05192 768494010178 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 768494010179 Walker A/P-loop; other site 768494010180 ATP binding site [chemical binding]; other site 768494010181 Q-loop/lid; other site 768494010182 ABC transporter signature motif; other site 768494010183 Walker B; other site 768494010184 D-loop; other site 768494010185 H-loop/switch region; other site 768494010186 Outer spore coat protein E (CotE); Region: CotE; pfam10628 768494010187 Predicted membrane protein [Function unknown]; Region: COG4550 768494010188 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 768494010189 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 768494010190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494010191 FeS/SAM binding site; other site 768494010192 TRAM domain; Region: TRAM; pfam01938 768494010193 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; Region: PorB_KorB; TIGR02177 768494010194 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 768494010195 TPP-binding site [chemical binding]; other site 768494010196 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 768494010197 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 768494010198 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 768494010199 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 768494010200 dimer interface [polypeptide binding]; other site 768494010201 PYR/PP interface [polypeptide binding]; other site 768494010202 TPP binding site [chemical binding]; other site 768494010203 substrate binding site [chemical binding]; other site 768494010204 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768494010205 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 768494010206 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 768494010207 active site 768494010208 dimer interface [polypeptide binding]; other site 768494010209 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 768494010210 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 768494010211 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768494010212 putative active site [active] 768494010213 metal binding site [ion binding]; metal-binding site 768494010214 homodimer binding site [polypeptide binding]; other site 768494010215 phosphodiesterase; Provisional; Region: PRK12704 768494010216 Uncharacterized conserved protein [Function unknown]; Region: COG3334 768494010217 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768494010218 Zn2+ binding site [ion binding]; other site 768494010219 Mg2+ binding site [ion binding]; other site 768494010220 recA bacterial DNA recombination protein; Region: RecA; cl17211 768494010221 recA bacterial DNA recombination protein; Region: RecA; cl17211 768494010222 competence damage-inducible protein A; Provisional; Region: PRK00549 768494010223 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 768494010224 putative MPT binding site; other site 768494010225 Competence-damaged protein; Region: CinA; pfam02464 768494010226 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 768494010227 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 768494010228 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494010229 non-specific DNA binding site [nucleotide binding]; other site 768494010230 salt bridge; other site 768494010231 sequence-specific DNA binding site [nucleotide binding]; other site 768494010232 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 768494010233 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768494010234 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 768494010235 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 768494010236 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 768494010237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494010238 NAD(P) binding site [chemical binding]; other site 768494010239 active site 768494010240 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 768494010241 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 768494010242 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768494010243 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 768494010244 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768494010245 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768494010246 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 768494010247 TM-ABC transporter signature motif; other site 768494010248 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 768494010249 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768494010250 TM-ABC transporter signature motif; other site 768494010251 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4603 768494010252 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 768494010253 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768494010254 Walker A/P-loop; other site 768494010255 ATP binding site [chemical binding]; other site 768494010256 Q-loop/lid; other site 768494010257 ABC transporter signature motif; other site 768494010258 Walker B; other site 768494010259 D-loop; other site 768494010260 H-loop/switch region; other site 768494010261 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768494010262 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 768494010263 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 768494010264 ligand binding site [chemical binding]; other site 768494010265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494010266 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768494010267 DNA-binding site [nucleotide binding]; DNA binding site 768494010268 UTRA domain; Region: UTRA; pfam07702 768494010269 Tetraspanin family; Region: Tetraspannin; pfam00335 768494010270 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 768494010271 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768494010272 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 768494010273 YlzJ-like protein; Region: YlzJ; pfam14035 768494010274 Clp protease; Region: CLP_protease; pfam00574 768494010275 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 768494010276 active site 768494010277 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 768494010278 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494010279 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 768494010280 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 768494010281 dihydrodipicolinate synthase; Region: dapA; TIGR00674 768494010282 dimer interface [polypeptide binding]; other site 768494010283 active site 768494010284 catalytic residue [active] 768494010285 aspartate kinase I; Reviewed; Region: PRK08210 768494010286 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 768494010287 nucleotide binding site [chemical binding]; other site 768494010288 substrate binding site [chemical binding]; other site 768494010289 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 768494010290 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 768494010291 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 768494010292 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768494010293 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 768494010294 dipicolinic acid synthetase, A subunit; Region: spore_dpaA; TIGR02853 768494010295 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 768494010296 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 768494010297 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 768494010298 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 768494010299 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768494010300 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 768494010301 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 768494010302 NodB motif; other site 768494010303 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 768494010304 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 768494010305 RNase E interface [polypeptide binding]; other site 768494010306 trimer interface [polypeptide binding]; other site 768494010307 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 768494010308 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 768494010309 RNase E interface [polypeptide binding]; other site 768494010310 trimer interface [polypeptide binding]; other site 768494010311 active site 768494010312 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 768494010313 putative nucleic acid binding region [nucleotide binding]; other site 768494010314 G-X-X-G motif; other site 768494010315 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 768494010316 RNA binding site [nucleotide binding]; other site 768494010317 domain interface; other site 768494010318 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 768494010319 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 768494010320 active site 768494010321 Riboflavin kinase; Region: Flavokinase; smart00904 768494010322 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 768494010323 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 768494010324 RNA binding site [nucleotide binding]; other site 768494010325 active site 768494010326 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 768494010327 Protein of unknown function (DUF503); Region: DUF503; pfam04456 768494010328 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768494010329 translation initiation factor IF-2; Region: IF-2; TIGR00487 768494010330 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768494010331 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 768494010332 G1 box; other site 768494010333 putative GEF interaction site [polypeptide binding]; other site 768494010334 GTP/Mg2+ binding site [chemical binding]; other site 768494010335 Switch I region; other site 768494010336 G2 box; other site 768494010337 G3 box; other site 768494010338 Switch II region; other site 768494010339 G4 box; other site 768494010340 G5 box; other site 768494010341 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 768494010342 Translation-initiation factor 2; Region: IF-2; pfam11987 768494010343 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 768494010344 hypothetical protein; Provisional; Region: PRK07714 768494010345 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 768494010346 putative RNA binding cleft [nucleotide binding]; other site 768494010347 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 768494010348 NusA N-terminal domain; Region: NusA_N; pfam08529 768494010349 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 768494010350 RNA binding site [nucleotide binding]; other site 768494010351 homodimer interface [polypeptide binding]; other site 768494010352 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 768494010353 G-X-X-G motif; other site 768494010354 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 768494010355 G-X-X-G motif; other site 768494010356 ribosome maturation protein RimP; Reviewed; Region: PRK00092 768494010357 Sm and related proteins; Region: Sm_like; cl00259 768494010358 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 768494010359 putative oligomer interface [polypeptide binding]; other site 768494010360 putative RNA binding site [nucleotide binding]; other site 768494010361 DNA polymerase III PolC; Validated; Region: polC; PRK00448 768494010362 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 768494010363 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 768494010364 generic binding surface II; other site 768494010365 generic binding surface I; other site 768494010366 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 768494010367 active site 768494010368 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768494010369 active site 768494010370 catalytic site [active] 768494010371 substrate binding site [chemical binding]; other site 768494010372 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 768494010373 prolyl-tRNA synthetase; Provisional; Region: PRK09194 768494010374 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 768494010375 dimer interface [polypeptide binding]; other site 768494010376 motif 1; other site 768494010377 active site 768494010378 motif 2; other site 768494010379 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 768494010380 putative deacylase active site [active] 768494010381 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768494010382 active site 768494010383 motif 3; other site 768494010384 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 768494010385 anticodon binding site; other site 768494010386 RIP metalloprotease RseP; Region: TIGR00054 768494010387 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768494010388 active site 768494010389 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 768494010390 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768494010391 protein binding site [polypeptide binding]; other site 768494010392 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768494010393 putative substrate binding region [chemical binding]; other site 768494010394 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 768494010395 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 768494010396 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 768494010397 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 768494010398 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 768494010399 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 768494010400 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 768494010401 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 768494010402 catalytic residue [active] 768494010403 putative FPP diphosphate binding site; other site 768494010404 putative FPP binding hydrophobic cleft; other site 768494010405 dimer interface [polypeptide binding]; other site 768494010406 putative IPP diphosphate binding site; other site 768494010407 ribosome recycling factor; Reviewed; Region: frr; PRK00083 768494010408 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 768494010409 hinge region; other site 768494010410 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 768494010411 putative nucleotide binding site [chemical binding]; other site 768494010412 uridine monophosphate binding site [chemical binding]; other site 768494010413 homohexameric interface [polypeptide binding]; other site 768494010414 elongation factor Ts; Provisional; Region: tsf; PRK09377 768494010415 UBA/TS-N domain; Region: UBA; pfam00627 768494010416 Elongation factor TS; Region: EF_TS; pfam00889 768494010417 Elongation factor TS; Region: EF_TS; pfam00889 768494010418 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 768494010419 rRNA interaction site [nucleotide binding]; other site 768494010420 S8 interaction site; other site 768494010421 putative laminin-1 binding site; other site 768494010422 transcriptional repressor CodY; Validated; Region: PRK04158 768494010423 CodY GAF-like domain; Region: CodY; pfam06018 768494010424 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 768494010425 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 768494010426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494010427 Walker A motif; other site 768494010428 ATP binding site [chemical binding]; other site 768494010429 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 768494010430 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768494010431 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 768494010432 active site 768494010433 HslU subunit interaction site [polypeptide binding]; other site 768494010434 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 768494010435 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 768494010436 active site 768494010437 Int/Topo IB signature motif; other site 768494010438 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 768494010439 Glucose inhibited division protein A; Region: GIDA; pfam01134 768494010440 DNA topoisomerase I; Validated; Region: PRK05582 768494010441 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 768494010442 active site 768494010443 metal binding site [ion binding]; metal-binding site 768494010444 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768494010445 domain I; other site 768494010446 DNA binding groove [nucleotide binding] 768494010447 phosphate binding site [ion binding]; other site 768494010448 domain II; other site 768494010449 domain III; other site 768494010450 nucleotide binding site [chemical binding]; other site 768494010451 catalytic site [active] 768494010452 domain IV; other site 768494010453 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768494010454 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768494010455 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 768494010456 DNA protecting protein DprA; Region: dprA; TIGR00732 768494010457 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 768494010458 CoA binding domain; Region: CoA_binding; smart00881 768494010459 CoA-ligase; Region: Ligase_CoA; pfam00549 768494010460 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 768494010461 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 768494010462 CoA-ligase; Region: Ligase_CoA; pfam00549 768494010463 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 768494010464 RNA/DNA hybrid binding site [nucleotide binding]; other site 768494010465 active site 768494010466 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 768494010467 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 768494010468 GTP/Mg2+ binding site [chemical binding]; other site 768494010469 G4 box; other site 768494010470 G5 box; other site 768494010471 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 768494010472 G1 box; other site 768494010473 G1 box; other site 768494010474 GTP/Mg2+ binding site [chemical binding]; other site 768494010475 Switch I region; other site 768494010476 G2 box; other site 768494010477 G2 box; other site 768494010478 G3 box; other site 768494010479 G3 box; other site 768494010480 Switch II region; other site 768494010481 Switch II region; other site 768494010482 G4 box; other site 768494010483 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 768494010484 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768494010485 Catalytic site [active] 768494010486 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768494010487 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 768494010488 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 768494010489 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 768494010490 RimM N-terminal domain; Region: RimM; pfam01782 768494010491 PRC-barrel domain; Region: PRC; pfam05239 768494010492 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 768494010493 KH domain; Region: KH_4; pfam13083 768494010494 G-X-X-G motif; other site 768494010495 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 768494010496 signal recognition particle protein; Provisional; Region: PRK10867 768494010497 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 768494010498 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768494010499 P loop; other site 768494010500 GTP binding site [chemical binding]; other site 768494010501 Signal peptide binding domain; Region: SRP_SPB; pfam02978 768494010502 putative DNA-binding protein; Validated; Region: PRK00118 768494010503 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 768494010504 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 768494010505 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 768494010506 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768494010507 P loop; other site 768494010508 GTP binding site [chemical binding]; other site 768494010509 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 768494010510 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 768494010511 Walker A/P-loop; other site 768494010512 ATP binding site [chemical binding]; other site 768494010513 Q-loop/lid; other site 768494010514 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 768494010515 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 768494010516 ABC transporter signature motif; other site 768494010517 Walker B; other site 768494010518 D-loop; other site 768494010519 H-loop/switch region; other site 768494010520 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 768494010521 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 768494010522 dimerization interface [polypeptide binding]; other site 768494010523 active site 768494010524 metal binding site [ion binding]; metal-binding site 768494010525 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 768494010526 dsRNA binding site [nucleotide binding]; other site 768494010527 acyl carrier protein; Provisional; Region: acpP; PRK00982 768494010528 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768494010529 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768494010530 NAD(P) binding site [chemical binding]; other site 768494010531 homotetramer interface [polypeptide binding]; other site 768494010532 homodimer interface [polypeptide binding]; other site 768494010533 active site 768494010534 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 768494010535 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 768494010536 putative phosphate acyltransferase; Provisional; Region: PRK05331 768494010537 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 768494010538 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 768494010539 active site 2 [active] 768494010540 active site 1 [active] 768494010541 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 768494010542 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 768494010543 generic binding surface II; other site 768494010544 ssDNA binding site; other site 768494010545 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768494010546 ATP binding site [chemical binding]; other site 768494010547 putative Mg++ binding site [ion binding]; other site 768494010548 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494010549 nucleotide binding region [chemical binding]; other site 768494010550 ATP-binding site [chemical binding]; other site 768494010551 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 768494010552 DAK2 domain; Region: Dak2; pfam02734 768494010553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 768494010554 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 768494010555 Thiamine pyrophosphokinase; Region: TPK; cd07995 768494010556 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 768494010557 active site 768494010558 dimerization interface [polypeptide binding]; other site 768494010559 thiamine binding site [chemical binding]; other site 768494010560 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 768494010561 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 768494010562 substrate binding site [chemical binding]; other site 768494010563 hexamer interface [polypeptide binding]; other site 768494010564 metal binding site [ion binding]; metal-binding site 768494010565 GTPase RsgA; Reviewed; Region: PRK00098 768494010566 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 768494010567 RNA binding site [nucleotide binding]; other site 768494010568 homodimer interface [polypeptide binding]; other site 768494010569 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 768494010570 GTPase/Zn-binding domain interface [polypeptide binding]; other site 768494010571 GTP/Mg2+ binding site [chemical binding]; other site 768494010572 G4 box; other site 768494010573 G5 box; other site 768494010574 G1 box; other site 768494010575 Switch I region; other site 768494010576 G2 box; other site 768494010577 G3 box; other site 768494010578 Switch II region; other site 768494010579 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 768494010580 Catalytic domain of Protein Kinases; Region: PKc; cd00180 768494010581 active site 768494010582 ATP binding site [chemical binding]; other site 768494010583 substrate binding site [chemical binding]; other site 768494010584 activation loop (A-loop); other site 768494010585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 768494010586 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 768494010587 PASTA domain; Region: PASTA; pfam03793 768494010588 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 768494010589 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 768494010590 Protein phosphatase 2C; Region: PP2C; pfam00481 768494010591 active site 768494010592 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 768494010593 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494010594 FeS/SAM binding site; other site 768494010595 16S rRNA methyltransferase B; Provisional; Region: PRK14902 768494010596 NusB family; Region: NusB; pfam01029 768494010597 putative RNA binding site [nucleotide binding]; other site 768494010598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494010599 S-adenosylmethionine binding site [chemical binding]; other site 768494010600 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 768494010601 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 768494010602 putative active site [active] 768494010603 substrate binding site [chemical binding]; other site 768494010604 putative cosubstrate binding site; other site 768494010605 catalytic site [active] 768494010606 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 768494010607 substrate binding site [chemical binding]; other site 768494010608 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 768494010609 active site 768494010610 catalytic residues [active] 768494010611 metal binding site [ion binding]; metal-binding site 768494010612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768494010613 primosomal protein N' Region: priA; TIGR00595 768494010614 ATP binding site [chemical binding]; other site 768494010615 putative Mg++ binding site [ion binding]; other site 768494010616 helicase superfamily c-terminal domain; Region: HELICc; smart00490 768494010617 nucleotide binding region [chemical binding]; other site 768494010618 ATP-binding site [chemical binding]; other site 768494010619 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 768494010620 Flavoprotein; Region: Flavoprotein; pfam02441 768494010621 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 768494010622 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 768494010623 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 768494010624 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 768494010625 catalytic site [active] 768494010626 G-X2-G-X-G-K; other site 768494010627 hypothetical protein; Provisional; Region: PRK04323 768494010628 hypothetical protein; Provisional; Region: PRK11820 768494010629 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 768494010630 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 768494010631 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 768494010632 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 768494010633 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768494010634 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 768494010635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494010636 motif II; other site 768494010637 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 768494010638 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 768494010639 Domain of unknown function (DUF814); Region: DUF814; pfam05670 768494010640 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768494010641 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768494010642 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 768494010643 active site 768494010644 YoqO-like protein; Region: YoqO; pfam14037 768494010645 YoqO-like protein; Region: YoqO; pfam14037 768494010646 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 768494010647 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 768494010648 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 768494010649 motif I; other site 768494010650 active site 768494010651 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768494010652 active site 768494010653 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 768494010654 active site 768494010655 dimer interface [polypeptide binding]; other site 768494010656 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 768494010657 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 768494010658 heterodimer interface [polypeptide binding]; other site 768494010659 active site 768494010660 FMN binding site [chemical binding]; other site 768494010661 homodimer interface [polypeptide binding]; other site 768494010662 substrate binding site [chemical binding]; other site 768494010663 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 768494010664 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 768494010665 FAD binding pocket [chemical binding]; other site 768494010666 FAD binding motif [chemical binding]; other site 768494010667 phosphate binding motif [ion binding]; other site 768494010668 beta-alpha-beta structure motif; other site 768494010669 NAD binding pocket [chemical binding]; other site 768494010670 Iron coordination center [ion binding]; other site 768494010671 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 768494010672 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768494010673 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768494010674 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 768494010675 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768494010676 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768494010677 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 768494010678 IMP binding site; other site 768494010679 dimer interface [polypeptide binding]; other site 768494010680 interdomain contacts; other site 768494010681 partial ornithine binding site; other site 768494010682 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 768494010683 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 768494010684 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 768494010685 catalytic site [active] 768494010686 subunit interface [polypeptide binding]; other site 768494010687 dihydroorotase; Validated; Region: pyrC; PRK09357 768494010688 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768494010689 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 768494010690 active site 768494010691 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 768494010692 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768494010693 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768494010694 uracil transporter; Provisional; Region: PRK10720 768494010695 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 768494010696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768494010697 active site 768494010698 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 768494010699 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768494010700 RNA binding surface [nucleotide binding]; other site 768494010701 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768494010702 active site 768494010703 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 768494010704 lipoprotein signal peptidase; Provisional; Region: PRK14787 768494010705 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 768494010706 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 768494010707 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768494010708 active site 768494010709 HIGH motif; other site 768494010710 nucleotide binding site [chemical binding]; other site 768494010711 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768494010712 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 768494010713 active site 768494010714 KMSKS motif; other site 768494010715 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 768494010716 tRNA binding surface [nucleotide binding]; other site 768494010717 anticodon binding site; other site 768494010718 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768494010719 DivIVA protein; Region: DivIVA; pfam05103 768494010720 DivIVA domain; Region: DivI1A_domain; TIGR03544 768494010721 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 768494010722 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 768494010723 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768494010724 RNA binding surface [nucleotide binding]; other site 768494010725 YGGT family; Region: YGGT; pfam02325 768494010726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 768494010727 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 768494010728 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768494010729 catalytic residue [active] 768494010730 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 768494010731 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 768494010732 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 768494010733 sporulation sigma factor SigG; Reviewed; Region: PRK08215 768494010734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494010735 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494010736 DNA binding residues [nucleotide binding] 768494010737 sporulation sigma factor SigE; Reviewed; Region: PRK08301 768494010738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494010739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494010740 DNA binding residues [nucleotide binding] 768494010741 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 768494010742 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 768494010743 cell division protein FtsZ; Validated; Region: PRK09330 768494010744 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 768494010745 nucleotide binding site [chemical binding]; other site 768494010746 SulA interaction site; other site 768494010747 cell division protein FtsA; Region: ftsA; TIGR01174 768494010748 Cell division protein FtsA; Region: FtsA; smart00842 768494010749 Cell division protein FtsA; Region: FtsA; pfam14450 768494010750 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 768494010751 Cell division protein FtsQ; Region: FtsQ; pfam03799 768494010752 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 768494010753 FAD binding domain; Region: FAD_binding_4; pfam01565 768494010754 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 768494010755 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 768494010756 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 768494010757 active site 768494010758 homodimer interface [polypeptide binding]; other site 768494010759 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 768494010760 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 768494010761 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 768494010762 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768494010763 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768494010764 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 768494010765 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 768494010766 Mg++ binding site [ion binding]; other site 768494010767 putative catalytic motif [active] 768494010768 putative substrate binding site [chemical binding]; other site 768494010769 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 768494010770 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768494010771 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768494010772 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768494010773 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 768494010774 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768494010775 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494010776 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 768494010777 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 768494010778 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768494010779 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494010780 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 768494010781 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 768494010782 Cell division protein FtsL; Region: FtsL; cl11433 768494010783 MraW methylase family; Region: Methyltransf_5; pfam01795 768494010784 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 768494010785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 768494010786 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 768494010787 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 768494010788 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768494010789 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768494010790 hypothetical protein; Provisional; Region: PRK13688 768494010791 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494010792 Coenzyme A binding pocket [chemical binding]; other site 768494010793 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 768494010794 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 768494010795 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 768494010796 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 768494010797 Replication-relaxation; Region: Replic_Relax; pfam13814 768494010798 potential frameshift: common BLAST hit: gi|227813163|ref|YP_002813172.1| prophage LambdaBa02, FtsK/SpoIIIE family protein 768494010799 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768494010800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494010801 non-specific DNA binding site [nucleotide binding]; other site 768494010802 salt bridge; other site 768494010803 sequence-specific DNA binding site [nucleotide binding]; other site 768494010804 hypothetical protein; Region: PHA02436 768494010805 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768494010806 amidase catalytic site [active] 768494010807 Zn binding residues [ion binding]; other site 768494010808 substrate binding site [chemical binding]; other site 768494010809 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 768494010810 Holin family; Region: Phage_holin_4; pfam05105 768494010811 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 768494010812 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 768494010813 active site 768494010814 catalytic residues [active] 768494010815 DNA binding site [nucleotide binding] 768494010816 Int/Topo IB signature motif; other site 768494010817 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 768494010818 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 768494010819 putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633 768494010820 Phage tail protein; Region: Sipho_tail; cl17486 768494010821 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 768494010822 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 768494010823 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 768494010824 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 768494010825 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 768494010826 oligomerization interface [polypeptide binding]; other site 768494010827 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 768494010828 Phage capsid family; Region: Phage_capsid; pfam05065 768494010829 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 768494010830 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 768494010831 oligomer interface [polypeptide binding]; other site 768494010832 active site residues [active] 768494010833 Phage-related protein [Function unknown]; Region: COG4695 768494010834 Phage portal protein; Region: Phage_portal; pfam04860 768494010835 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 768494010836 Phage terminase, small subunit; Region: Terminase_4; pfam05119 768494010837 HNH endonuclease; Region: HNH; pfam01844 768494010838 active site 768494010839 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 768494010840 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 768494010841 Int/Topo IB signature motif; other site 768494010842 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 768494010843 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 768494010844 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 768494010845 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 768494010846 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768494010847 active site 768494010848 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768494010849 trimer interface [polypeptide binding]; other site 768494010850 active site 768494010851 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 768494010852 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494010853 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494010854 sequence-specific DNA binding site [nucleotide binding]; other site 768494010855 salt bridge; other site 768494010856 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 768494010857 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 768494010858 hypothetical protein; Validated; Region: PRK08116 768494010859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494010860 Walker A motif; other site 768494010861 ATP binding site [chemical binding]; other site 768494010862 Helix-turn-helix domain; Region: HTH_36; pfam13730 768494010863 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 768494010864 Inositol polyphosphate kinase; Region: IPK; cl12283 768494010865 Helix-turn-helix domain; Region: HTH_17; pfam12728 768494010866 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494010867 non-specific DNA binding site [nucleotide binding]; other site 768494010868 salt bridge; other site 768494010869 sequence-specific DNA binding site [nucleotide binding]; other site 768494010870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494010871 non-specific DNA binding site [nucleotide binding]; other site 768494010872 salt bridge; other site 768494010873 sequence-specific DNA binding site [nucleotide binding]; other site 768494010874 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 768494010875 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 768494010876 Int/Topo IB signature motif; other site 768494010877 hypothetical protein; Provisional; Region: PRK13670 768494010878 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 768494010879 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 768494010880 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 768494010881 protein binding site [polypeptide binding]; other site 768494010882 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768494010883 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 768494010884 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 768494010885 active site 768494010886 nucleophile elbow; other site 768494010887 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 768494010888 Nucleoside recognition; Region: Gate; pfam07670 768494010889 Nucleoside recognition; Region: Gate; pfam07670 768494010890 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 768494010891 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 768494010892 active site 768494010893 (T/H)XGH motif; other site 768494010894 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 768494010895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494010896 S-adenosylmethionine binding site [chemical binding]; other site 768494010897 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 768494010898 Protein of unknown function (DUF964); Region: DUF964; pfam06133 768494010899 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768494010900 catalytic core [active] 768494010901 YlbE-like protein; Region: YlbE; pfam14003 768494010902 Putative coat protein; Region: YlbD_coat; pfam14071 768494010903 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 768494010904 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 768494010905 YugN-like family; Region: YugN; pfam08868 768494010906 formamidase; Provisional; Region: amiF; PRK13287 768494010907 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 768494010908 multimer interface [polypeptide binding]; other site 768494010909 active site 768494010910 catalytic triad [active] 768494010911 dimer interface [polypeptide binding]; other site 768494010912 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 768494010913 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 768494010914 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 768494010915 Subunit I/III interface [polypeptide binding]; other site 768494010916 Subunit III/IV interface [polypeptide binding]; other site 768494010917 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 768494010918 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 768494010919 D-pathway; other site 768494010920 Putative ubiquinol binding site [chemical binding]; other site 768494010921 Low-spin heme (heme b) binding site [chemical binding]; other site 768494010922 Putative water exit pathway; other site 768494010923 Binuclear center (heme o3/CuB) [ion binding]; other site 768494010924 K-pathway; other site 768494010925 Putative proton exit pathway; other site 768494010926 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 768494010927 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 768494010928 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768494010929 Cytochrome c; Region: Cytochrom_C; pfam00034 768494010930 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 768494010931 UbiA prenyltransferase family; Region: UbiA; pfam01040 768494010932 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 768494010933 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 768494010934 pyruvate carboxylase; Reviewed; Region: PRK12999 768494010935 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768494010936 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768494010937 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768494010938 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 768494010939 active site 768494010940 catalytic residues [active] 768494010941 metal binding site [ion binding]; metal-binding site 768494010942 homodimer binding site [polypeptide binding]; other site 768494010943 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768494010944 carboxyltransferase (CT) interaction site; other site 768494010945 biotinylation site [posttranslational modification]; other site 768494010946 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 768494010947 hypothetical protein; Provisional; Region: PRK13666 768494010948 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768494010949 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 768494010950 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 768494010951 putative active site [active] 768494010952 PhoH-like protein; Region: PhoH; pfam02562 768494010953 hypothetical protein; Provisional; Region: PRK06733 768494010954 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 768494010955 YlaH-like protein; Region: YlaH; pfam14036 768494010956 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 768494010957 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 768494010958 G1 box; other site 768494010959 putative GEF interaction site [polypeptide binding]; other site 768494010960 GTP/Mg2+ binding site [chemical binding]; other site 768494010961 Switch I region; other site 768494010962 G2 box; other site 768494010963 G3 box; other site 768494010964 Switch II region; other site 768494010965 G4 box; other site 768494010966 G5 box; other site 768494010967 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 768494010968 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 768494010969 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768494010970 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 768494010971 active site 768494010972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 768494010973 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 768494010974 hypothetical protein; Provisional; Region: PRK04387 768494010975 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 768494010976 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 768494010977 homodimer interface [polypeptide binding]; other site 768494010978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494010979 catalytic residue [active] 768494010980 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 768494010981 transglutaminase; Provisional; Region: tgl; PRK03187 768494010982 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 768494010983 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 768494010984 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 768494010985 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 768494010986 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 768494010987 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 768494010988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494010989 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768494010990 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 768494010991 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768494010992 E3 interaction surface; other site 768494010993 lipoyl attachment site [posttranslational modification]; other site 768494010994 e3 binding domain; Region: E3_binding; pfam02817 768494010995 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768494010996 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 768494010997 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 768494010998 alpha subunit interface [polypeptide binding]; other site 768494010999 TPP binding site [chemical binding]; other site 768494011000 heterodimer interface [polypeptide binding]; other site 768494011001 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768494011002 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 768494011003 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 768494011004 TPP-binding site [chemical binding]; other site 768494011005 heterodimer interface [polypeptide binding]; other site 768494011006 tetramer interface [polypeptide binding]; other site 768494011007 phosphorylation loop region [posttranslational modification] 768494011008 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 768494011009 active site 768494011010 catalytic residues [active] 768494011011 metal binding site [ion binding]; metal-binding site 768494011012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494011013 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768494011014 active site 768494011015 motif I; other site 768494011016 motif II; other site 768494011017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494011018 hypothetical protein; Provisional; Region: PRK13667 768494011019 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 768494011020 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494011021 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 768494011022 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 768494011023 TrkA-N domain; Region: TrkA_N; pfam02254 768494011024 TrkA-C domain; Region: TrkA_C; pfam02080 768494011025 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 768494011026 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768494011027 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 768494011028 metal binding site [ion binding]; metal-binding site 768494011029 putative dimer interface [polypeptide binding]; other site 768494011030 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 768494011031 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 768494011032 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 768494011033 trimer interface [polypeptide binding]; other site 768494011034 active site 768494011035 substrate binding site [chemical binding]; other site 768494011036 CoA binding site [chemical binding]; other site 768494011037 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768494011038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494011039 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768494011040 dimerization interface [polypeptide binding]; other site 768494011041 FOG: CBS domain [General function prediction only]; Region: COG0517 768494011042 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 768494011043 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 768494011044 Protein of unknown function (DUF458); Region: DUF458; pfam04308 768494011045 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 768494011046 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 768494011047 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 768494011048 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768494011049 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 768494011050 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 768494011051 short chain dehydrogenase; Provisional; Region: PRK07677 768494011052 NAD(P) binding site [chemical binding]; other site 768494011053 substrate binding site [chemical binding]; other site 768494011054 homotetramer interface [polypeptide binding]; other site 768494011055 active site 768494011056 homodimer interface [polypeptide binding]; other site 768494011057 phosphodiesterase YaeI; Provisional; Region: PRK11340 768494011058 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 768494011059 putative active site [active] 768494011060 putative metal binding site [ion binding]; other site 768494011061 polyphosphate kinase; Provisional; Region: PRK05443 768494011062 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 768494011063 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 768494011064 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 768494011065 putative domain interface [polypeptide binding]; other site 768494011066 putative active site [active] 768494011067 catalytic site [active] 768494011068 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 768494011069 putative domain interface [polypeptide binding]; other site 768494011070 putative active site [active] 768494011071 catalytic site [active] 768494011072 exopolyphosphatase; Region: exo_poly_only; TIGR03706 768494011073 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768494011074 nucleotide binding site [chemical binding]; other site 768494011075 YkyB-like protein; Region: YkyB; pfam14177 768494011076 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 768494011077 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768494011078 I-site; other site 768494011079 active site 768494011080 metal binding site [ion binding]; metal-binding site 768494011081 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494011082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494011083 putative substrate translocation pore; other site 768494011084 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494011085 Transcriptional regulator PadR-like family; Region: PadR; cl17335 768494011086 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 768494011087 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 768494011088 THF binding site; other site 768494011089 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768494011090 substrate binding site [chemical binding]; other site 768494011091 THF binding site; other site 768494011092 zinc-binding site [ion binding]; other site 768494011093 Competence protein J (ComJ); Region: ComJ; pfam11033 768494011094 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 768494011095 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 768494011096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494011097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494011098 dimer interface [polypeptide binding]; other site 768494011099 phosphorylation site [posttranslational modification] 768494011100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494011101 ATP binding site [chemical binding]; other site 768494011102 Mg2+ binding site [ion binding]; other site 768494011103 G-X-G motif; other site 768494011104 aminotransferase A; Validated; Region: PRK07683 768494011105 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494011106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494011107 homodimer interface [polypeptide binding]; other site 768494011108 catalytic residue [active] 768494011109 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768494011110 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768494011111 DNA binding site [nucleotide binding] 768494011112 domain linker motif; other site 768494011113 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 768494011114 putative dimerization interface [polypeptide binding]; other site 768494011115 putative ligand binding site [chemical binding]; other site 768494011116 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768494011117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494011118 dimer interface [polypeptide binding]; other site 768494011119 conserved gate region; other site 768494011120 putative PBP binding loops; other site 768494011121 ABC-ATPase subunit interface; other site 768494011122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494011123 dimer interface [polypeptide binding]; other site 768494011124 conserved gate region; other site 768494011125 putative PBP binding loops; other site 768494011126 ABC-ATPase subunit interface; other site 768494011127 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 768494011128 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768494011129 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 768494011130 homodimer interface [polypeptide binding]; other site 768494011131 maltodextrin glucosidase; Provisional; Region: PRK10785 768494011132 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 768494011133 active site 768494011134 homodimer interface [polypeptide binding]; other site 768494011135 catalytic site [active] 768494011136 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 768494011137 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 768494011138 Ca binding site [ion binding]; other site 768494011139 active site 768494011140 catalytic site [active] 768494011141 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768494011142 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768494011143 Walker A/P-loop; other site 768494011144 ATP binding site [chemical binding]; other site 768494011145 Q-loop/lid; other site 768494011146 ABC transporter signature motif; other site 768494011147 Walker B; other site 768494011148 D-loop; other site 768494011149 H-loop/switch region; other site 768494011150 TOBE domain; Region: TOBE_2; pfam08402 768494011151 hypothetical protein; Provisional; Region: PRK06720 768494011152 NAD(P) binding site [chemical binding]; other site 768494011153 RDD family; Region: RDD; pfam06271 768494011154 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 768494011155 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 768494011156 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 768494011157 Predicted ATPase [General function prediction only]; Region: COG3910 768494011158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494011159 Walker A/P-loop; other site 768494011160 ATP binding site [chemical binding]; other site 768494011161 Q-loop/lid; other site 768494011162 ABC transporter signature motif; other site 768494011163 Walker B; other site 768494011164 D-loop; other site 768494011165 H-loop/switch region; other site 768494011166 putative acyltransferase; Provisional; Region: PRK05790 768494011167 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768494011168 dimer interface [polypeptide binding]; other site 768494011169 active site 768494011170 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 768494011171 nudix motif; other site 768494011172 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 768494011173 hypothetical protein; Validated; Region: PRK07668 768494011174 hypothetical protein; Validated; Region: PRK07668 768494011175 hypothetical protein; Validated; Region: PRK07668 768494011176 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494011177 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 768494011178 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 768494011179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494011180 NAD(P) binding site [chemical binding]; other site 768494011181 active site 768494011182 YvrJ protein family; Region: YvrJ; pfam12841 768494011183 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 768494011184 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 768494011185 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 768494011186 Phosphotransferase enzyme family; Region: APH; pfam01636 768494011187 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768494011188 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 768494011189 putative active site [active] 768494011190 catalytic triad [active] 768494011191 putative dimer interface [polypeptide binding]; other site 768494011192 transaminase; Reviewed; Region: PRK08068 768494011193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494011194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494011195 homodimer interface [polypeptide binding]; other site 768494011196 catalytic residue [active] 768494011197 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 768494011198 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 768494011199 dimer interface [polypeptide binding]; other site 768494011200 active site 768494011201 catalytic residue [active] 768494011202 metal binding site [ion binding]; metal-binding site 768494011203 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 768494011204 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 768494011205 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 768494011206 intersubunit interface [polypeptide binding]; other site 768494011207 active site 768494011208 Zn2+ binding site [ion binding]; other site 768494011209 ARD/ARD' family; Region: ARD; pfam03079 768494011210 Cupin domain; Region: Cupin_2; pfam07883 768494011211 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 768494011212 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 768494011213 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768494011214 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 768494011215 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768494011216 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768494011217 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768494011218 metal binding site [ion binding]; metal-binding site 768494011219 active site 768494011220 I-site; other site 768494011221 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 768494011222 dimer interface [polypeptide binding]; other site 768494011223 FMN binding site [chemical binding]; other site 768494011224 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 768494011225 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 768494011226 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768494011227 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768494011228 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768494011229 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768494011230 dimerization domain swap beta strand [polypeptide binding]; other site 768494011231 regulatory protein interface [polypeptide binding]; other site 768494011232 active site 768494011233 regulatory phosphorylation site [posttranslational modification]; other site 768494011234 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768494011235 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 768494011236 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 768494011237 active site turn [active] 768494011238 phosphorylation site [posttranslational modification] 768494011239 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768494011240 HPr interaction site; other site 768494011241 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768494011242 active site 768494011243 phosphorylation site [posttranslational modification] 768494011244 transcriptional antiterminator BglG; Provisional; Region: PRK09772 768494011245 CAT RNA binding domain; Region: CAT_RBD; smart01061 768494011246 PRD domain; Region: PRD; pfam00874 768494011247 PRD domain; Region: PRD; pfam00874 768494011248 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768494011249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494011250 active site 768494011251 motif I; other site 768494011252 motif II; other site 768494011253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494011254 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768494011255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494011256 DNA-binding site [nucleotide binding]; DNA binding site 768494011257 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 768494011258 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 768494011259 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 768494011260 active site 768494011261 trimer interface [polypeptide binding]; other site 768494011262 allosteric site; other site 768494011263 active site lid [active] 768494011264 hexamer (dimer of trimers) interface [polypeptide binding]; other site 768494011265 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 768494011266 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 768494011267 active site 768494011268 dimer interface [polypeptide binding]; other site 768494011269 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 768494011270 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494011271 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 768494011272 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 768494011273 Domain of unknown function (DUF309); Region: DUF309; pfam03745 768494011274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494011275 Coenzyme A binding pocket [chemical binding]; other site 768494011276 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 768494011277 active site 768494011278 Predicted secreted protein [Function unknown]; Region: COG4086 768494011279 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 768494011280 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768494011281 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 768494011282 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768494011283 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 768494011284 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 768494011285 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 768494011286 stage V sporulation protein AD; Validated; Region: PRK08304 768494011287 stage V sporulation protein AD; Provisional; Region: PRK12404 768494011288 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 768494011289 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 768494011290 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 768494011291 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 768494011292 Na2 binding site [ion binding]; other site 768494011293 putative substrate binding site 1 [chemical binding]; other site 768494011294 Na binding site 1 [ion binding]; other site 768494011295 putative substrate binding site 2 [chemical binding]; other site 768494011296 sporulation sigma factor SigF; Validated; Region: PRK05572 768494011297 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494011298 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768494011299 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494011300 DNA binding residues [nucleotide binding] 768494011301 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 768494011302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494011303 ATP binding site [chemical binding]; other site 768494011304 Mg2+ binding site [ion binding]; other site 768494011305 G-X-G motif; other site 768494011306 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 768494011307 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768494011308 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768494011309 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 768494011310 Predicted transcriptional regulators [Transcription]; Region: COG1725 768494011311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494011312 DNA-binding site [nucleotide binding]; DNA binding site 768494011313 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494011314 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494011315 Walker A/P-loop; other site 768494011316 ATP binding site [chemical binding]; other site 768494011317 Q-loop/lid; other site 768494011318 ABC transporter signature motif; other site 768494011319 Walker B; other site 768494011320 D-loop; other site 768494011321 H-loop/switch region; other site 768494011322 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 768494011323 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494011324 MarR family; Region: MarR; pfam01047 768494011325 MarR family; Region: MarR_2; cl17246 768494011326 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 768494011327 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768494011328 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 768494011329 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768494011330 oligomer interface [polypeptide binding]; other site 768494011331 metal binding site [ion binding]; metal-binding site 768494011332 metal binding site [ion binding]; metal-binding site 768494011333 putative Cl binding site [ion binding]; other site 768494011334 aspartate ring; other site 768494011335 basic sphincter; other site 768494011336 hydrophobic gate; other site 768494011337 periplasmic entrance; other site 768494011338 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 768494011339 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768494011340 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768494011341 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 768494011342 purine nucleoside phosphorylase; Provisional; Region: PRK08202 768494011343 phosphopentomutase; Provisional; Region: PRK05362 768494011344 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 768494011345 YtkA-like; Region: YtkA; pfam13115 768494011346 YtkA-like; Region: YtkA; pfam13115 768494011347 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 768494011348 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 768494011349 active site 768494011350 Int/Topo IB signature motif; other site 768494011351 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 768494011352 ferric uptake regulator; Provisional; Region: fur; PRK09462 768494011353 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768494011354 metal binding site 2 [ion binding]; metal-binding site 768494011355 putative DNA binding helix; other site 768494011356 metal binding site 1 [ion binding]; metal-binding site 768494011357 dimer interface [polypeptide binding]; other site 768494011358 structural Zn2+ binding site [ion binding]; other site 768494011359 stage II sporulation protein M; Region: spo_II_M; TIGR02831 768494011360 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494011361 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494011362 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768494011363 dimer interface [polypeptide binding]; other site 768494011364 ADP-ribose binding site [chemical binding]; other site 768494011365 active site 768494011366 nudix motif; other site 768494011367 metal binding site [ion binding]; metal-binding site 768494011368 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 768494011369 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768494011370 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768494011371 active site 768494011372 catalytic tetrad [active] 768494011373 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768494011374 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768494011375 active site 768494011376 catalytic tetrad [active] 768494011377 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 768494011378 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 768494011379 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 768494011380 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 768494011381 putative active site [active] 768494011382 putative metal binding site [ion binding]; other site 768494011383 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768494011384 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 768494011385 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 768494011386 Predicted permease [General function prediction only]; Region: COG2056 768494011387 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 768494011388 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 768494011389 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768494011390 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768494011391 DNA binding site [nucleotide binding] 768494011392 domain linker motif; other site 768494011393 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768494011394 dimerization interface [polypeptide binding]; other site 768494011395 ligand binding site [chemical binding]; other site 768494011396 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768494011397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494011398 Coenzyme A binding pocket [chemical binding]; other site 768494011399 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 768494011400 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 768494011401 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 768494011402 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 768494011403 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 768494011404 catalytic motif [active] 768494011405 Zn binding site [ion binding]; other site 768494011406 RibD C-terminal domain; Region: RibD_C; cl17279 768494011407 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 768494011408 Lumazine binding domain; Region: Lum_binding; pfam00677 768494011409 Lumazine binding domain; Region: Lum_binding; pfam00677 768494011410 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 768494011411 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 768494011412 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 768494011413 dimerization interface [polypeptide binding]; other site 768494011414 active site 768494011415 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 768494011416 homopentamer interface [polypeptide binding]; other site 768494011417 active site 768494011418 biotin synthase; Validated; Region: PRK06256 768494011419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494011420 FeS/SAM binding site; other site 768494011421 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 768494011422 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 768494011423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494011424 S-adenosylmethionine binding site [chemical binding]; other site 768494011425 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768494011426 TAP-like protein; Region: Abhydrolase_4; pfam08386 768494011427 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768494011428 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 768494011429 substrate-cofactor binding pocket; other site 768494011430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494011431 catalytic residue [active] 768494011432 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 768494011433 AAA domain; Region: AAA_26; pfam13500 768494011434 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 768494011435 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768494011436 inhibitor-cofactor binding pocket; inhibition site 768494011437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494011438 catalytic residue [active] 768494011439 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 768494011440 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 768494011441 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 768494011442 active site 768494011443 metal binding site [ion binding]; metal-binding site 768494011444 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768494011445 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 768494011446 active site 768494011447 catalytic triad [active] 768494011448 oxyanion hole [active] 768494011449 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494011450 dimerization interface [polypeptide binding]; other site 768494011451 putative DNA binding site [nucleotide binding]; other site 768494011452 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494011453 putative Zn2+ binding site [ion binding]; other site 768494011454 ornithine carbamoyltransferase; Provisional; Region: PRK00779 768494011455 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768494011456 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768494011457 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 768494011458 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768494011459 inhibitor-cofactor binding pocket; inhibition site 768494011460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494011461 catalytic residue [active] 768494011462 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 768494011463 nucleotide binding site [chemical binding]; other site 768494011464 N-acetyl-L-glutamate binding site [chemical binding]; other site 768494011465 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 768494011466 heterotetramer interface [polypeptide binding]; other site 768494011467 active site pocket [active] 768494011468 cleavage site 768494011469 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 768494011470 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768494011471 YqzH-like protein; Region: YqzH; pfam14164 768494011472 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 768494011473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494011474 NAD(P) binding site [chemical binding]; other site 768494011475 active site 768494011476 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494011477 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 768494011478 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 768494011479 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 768494011480 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 768494011481 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 768494011482 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 768494011483 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 768494011484 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 768494011485 putative L-serine binding site [chemical binding]; other site 768494011486 ribonuclease Z; Region: RNase_Z; TIGR02651 768494011487 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 768494011488 DNA polymerase IV; Validated; Region: PRK01810 768494011489 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 768494011490 active site 768494011491 DNA binding site [nucleotide binding] 768494011492 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 768494011493 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 768494011494 peptidase T-like protein; Region: PepT-like; TIGR01883 768494011495 metal binding site [ion binding]; metal-binding site 768494011496 putative dimer interface [polypeptide binding]; other site 768494011497 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494011498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494011499 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 768494011500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 768494011501 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768494011502 Predicted membrane protein [Function unknown]; Region: COG4129 768494011503 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 768494011504 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 768494011505 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768494011506 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768494011507 Walker A/P-loop; other site 768494011508 ATP binding site [chemical binding]; other site 768494011509 Q-loop/lid; other site 768494011510 ABC transporter signature motif; other site 768494011511 Walker B; other site 768494011512 D-loop; other site 768494011513 H-loop/switch region; other site 768494011514 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768494011515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494011516 dimer interface [polypeptide binding]; other site 768494011517 conserved gate region; other site 768494011518 putative PBP binding loops; other site 768494011519 ABC-ATPase subunit interface; other site 768494011520 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768494011521 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768494011522 substrate binding pocket [chemical binding]; other site 768494011523 membrane-bound complex binding site; other site 768494011524 hinge residues; other site 768494011525 Disulphide isomerase; Region: Disulph_isomer; pfam06491 768494011526 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 768494011527 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 768494011528 nudix motif; other site 768494011529 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 768494011530 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 768494011531 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768494011532 E3 interaction surface; other site 768494011533 lipoyl attachment site [posttranslational modification]; other site 768494011534 e3 binding domain; Region: E3_binding; pfam02817 768494011535 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768494011536 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 768494011537 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 768494011538 alpha subunit interface [polypeptide binding]; other site 768494011539 TPP binding site [chemical binding]; other site 768494011540 heterodimer interface [polypeptide binding]; other site 768494011541 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768494011542 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 768494011543 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 768494011544 tetramer interface [polypeptide binding]; other site 768494011545 TPP-binding site [chemical binding]; other site 768494011546 heterodimer interface [polypeptide binding]; other site 768494011547 phosphorylation loop region [posttranslational modification] 768494011548 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 768494011549 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 768494011550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494011551 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768494011552 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768494011553 nucleotide binding site [chemical binding]; other site 768494011554 Acetokinase family; Region: Acetate_kinase; cl17229 768494011555 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 768494011556 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 768494011557 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 768494011558 NAD binding site [chemical binding]; other site 768494011559 Phe binding site; other site 768494011560 phosphate butyryltransferase; Validated; Region: PRK07742 768494011561 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 768494011562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494011563 putative active site [active] 768494011564 heme pocket [chemical binding]; other site 768494011565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494011566 putative active site [active] 768494011567 heme pocket [chemical binding]; other site 768494011568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494011569 Walker A motif; other site 768494011570 ATP binding site [chemical binding]; other site 768494011571 Walker B motif; other site 768494011572 arginine finger; other site 768494011573 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768494011574 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 768494011575 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768494011576 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 768494011577 active site 768494011578 catalytic site [active] 768494011579 metal binding site [ion binding]; metal-binding site 768494011580 dimer interface [polypeptide binding]; other site 768494011581 YycC-like protein; Region: YycC; pfam14174 768494011582 conserved hypothetical integral membrane protein; Region: TIGR03766 768494011583 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 768494011584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494011585 active site 768494011586 phosphorylation site [posttranslational modification] 768494011587 intermolecular recognition site; other site 768494011588 dimerization interface [polypeptide binding]; other site 768494011589 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 768494011590 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 768494011591 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768494011592 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 768494011593 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 768494011594 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768494011595 Walker A/P-loop; other site 768494011596 ATP binding site [chemical binding]; other site 768494011597 Q-loop/lid; other site 768494011598 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768494011599 ABC transporter signature motif; other site 768494011600 Walker B; other site 768494011601 D-loop; other site 768494011602 H-loop/switch region; other site 768494011603 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 768494011604 arginine repressor; Provisional; Region: PRK04280 768494011605 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 768494011606 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 768494011607 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768494011608 RNA binding surface [nucleotide binding]; other site 768494011609 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 768494011610 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 768494011611 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 768494011612 TPP-binding site; other site 768494011613 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768494011614 PYR/PP interface [polypeptide binding]; other site 768494011615 dimer interface [polypeptide binding]; other site 768494011616 TPP binding site [chemical binding]; other site 768494011617 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768494011618 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768494011619 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768494011620 substrate binding pocket [chemical binding]; other site 768494011621 chain length determination region; other site 768494011622 substrate-Mg2+ binding site; other site 768494011623 catalytic residues [active] 768494011624 aspartate-rich region 1; other site 768494011625 active site lid residues [active] 768494011626 aspartate-rich region 2; other site 768494011627 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 768494011628 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 768494011629 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 768494011630 generic binding surface II; other site 768494011631 generic binding surface I; other site 768494011632 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 768494011633 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 768494011634 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 768494011635 homodimer interface [polypeptide binding]; other site 768494011636 NADP binding site [chemical binding]; other site 768494011637 substrate binding site [chemical binding]; other site 768494011638 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 768494011639 Asp23 family; Region: Asp23; pfam03780 768494011640 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 768494011641 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768494011642 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768494011643 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768494011644 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 768494011645 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768494011646 carboxyltransferase (CT) interaction site; other site 768494011647 biotinylation site [posttranslational modification]; other site 768494011648 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 768494011649 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 768494011650 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 768494011651 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 768494011652 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 768494011653 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 768494011654 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 768494011655 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 768494011656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494011657 Walker A motif; other site 768494011658 ATP binding site [chemical binding]; other site 768494011659 Walker B motif; other site 768494011660 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 768494011661 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494011662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494011663 elongation factor P; Validated; Region: PRK00529 768494011664 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 768494011665 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 768494011666 RNA binding site [nucleotide binding]; other site 768494011667 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 768494011668 RNA binding site [nucleotide binding]; other site 768494011669 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768494011670 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768494011671 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 768494011672 active site 768494011673 Dehydroquinase class II; Region: DHquinase_II; pfam01220 768494011674 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 768494011675 trimer interface [polypeptide binding]; other site 768494011676 active site 768494011677 dimer interface [polypeptide binding]; other site 768494011678 Conserved membrane protein YqhR; Region: YqhR; pfam11085 768494011679 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 768494011680 CCC1-related family of proteins; Region: CCC1_like; cl00278 768494011681 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 768494011682 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768494011683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494011684 motif II; other site 768494011685 manganese transport transcriptional regulator; Provisional; Region: PRK03902 768494011686 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 768494011687 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 768494011688 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 768494011689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494011690 FeS/SAM binding site; other site 768494011691 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768494011692 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768494011693 active site residue [active] 768494011694 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768494011695 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768494011696 DNA binding site [nucleotide binding] 768494011697 domain linker motif; other site 768494011698 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 768494011699 putative dimerization interface [polypeptide binding]; other site 768494011700 putative ligand binding site [chemical binding]; other site 768494011701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494011702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494011703 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 768494011704 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 768494011705 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 768494011706 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 768494011707 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 768494011708 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 768494011709 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 768494011710 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494011711 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494011712 Walker A/P-loop; other site 768494011713 ATP binding site [chemical binding]; other site 768494011714 Q-loop/lid; other site 768494011715 ABC transporter signature motif; other site 768494011716 Walker B; other site 768494011717 D-loop; other site 768494011718 H-loop/switch region; other site 768494011719 Predicted transcriptional regulators [Transcription]; Region: COG1725 768494011720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494011721 DNA-binding site [nucleotide binding]; DNA binding site 768494011722 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 768494011723 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 768494011724 tetramer interface [polypeptide binding]; other site 768494011725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494011726 catalytic residue [active] 768494011727 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 768494011728 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 768494011729 tetramer interface [polypeptide binding]; other site 768494011730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494011731 catalytic residue [active] 768494011732 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 768494011733 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 768494011734 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 768494011735 DEAD-like helicases superfamily; Region: DEXDc; smart00487 768494011736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768494011737 ATP binding site [chemical binding]; other site 768494011738 putative Mg++ binding site [ion binding]; other site 768494011739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494011740 nucleotide binding region [chemical binding]; other site 768494011741 ATP-binding site [chemical binding]; other site 768494011742 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 768494011743 YqzE-like protein; Region: YqzE; pfam14038 768494011744 Shikimate kinase; Region: SKI; pfam01202 768494011745 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 768494011746 ADP binding site [chemical binding]; other site 768494011747 magnesium binding site [ion binding]; other site 768494011748 putative shikimate binding site; other site 768494011749 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 768494011750 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 768494011751 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 768494011752 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768494011753 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768494011754 Type II/IV secretion system protein; Region: T2SE; pfam00437 768494011755 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768494011756 Walker A motif; other site 768494011757 ATP binding site [chemical binding]; other site 768494011758 Walker B motif; other site 768494011759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494011760 putative DNA binding site [nucleotide binding]; other site 768494011761 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 768494011762 putative Zn2+ binding site [ion binding]; other site 768494011763 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 768494011764 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 768494011765 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768494011766 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 768494011767 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 768494011768 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768494011769 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 768494011770 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 768494011771 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 768494011772 active site 768494011773 homodimer interface [polypeptide binding]; other site 768494011774 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 768494011775 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 768494011776 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 768494011777 substrate binding pocket [chemical binding]; other site 768494011778 dimer interface [polypeptide binding]; other site 768494011779 inhibitor binding site; inhibition site 768494011780 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 768494011781 B12 binding site [chemical binding]; other site 768494011782 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 768494011783 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 768494011784 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 768494011785 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 768494011786 FAD binding site [chemical binding]; other site 768494011787 cystathionine gamma-synthase; Reviewed; Region: PRK08247 768494011788 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768494011789 homodimer interface [polypeptide binding]; other site 768494011790 substrate-cofactor binding pocket; other site 768494011791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494011792 catalytic residue [active] 768494011793 cystathionine beta-lyase; Provisional; Region: PRK08064 768494011794 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768494011795 homodimer interface [polypeptide binding]; other site 768494011796 substrate-cofactor binding pocket; other site 768494011797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494011798 catalytic residue [active] 768494011799 Isochorismatase family; Region: Isochorismatase; pfam00857 768494011800 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 768494011801 catalytic triad [active] 768494011802 conserved cis-peptide bond; other site 768494011803 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494011804 dimerization interface [polypeptide binding]; other site 768494011805 putative DNA binding site [nucleotide binding]; other site 768494011806 putative Zn2+ binding site [ion binding]; other site 768494011807 Uncharacterized conserved protein [Function unknown]; Region: COG1565 768494011808 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768494011809 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 768494011810 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 768494011811 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768494011812 nucleotide binding site [chemical binding]; other site 768494011813 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 768494011814 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 768494011815 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 768494011816 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 768494011817 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 768494011818 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 768494011819 active site 768494011820 Substrate binding site; other site 768494011821 Mg++ binding site; other site 768494011822 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 768494011823 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 768494011824 active site 768494011825 metal binding site [ion binding]; metal-binding site 768494011826 substrate binding site [chemical binding]; other site 768494011827 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 768494011828 PhoU domain; Region: PhoU; pfam01895 768494011829 PhoU domain; Region: PhoU; pfam01895 768494011830 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 768494011831 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 768494011832 Walker A/P-loop; other site 768494011833 ATP binding site [chemical binding]; other site 768494011834 Q-loop/lid; other site 768494011835 ABC transporter signature motif; other site 768494011836 Walker B; other site 768494011837 D-loop; other site 768494011838 H-loop/switch region; other site 768494011839 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 768494011840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494011841 dimer interface [polypeptide binding]; other site 768494011842 conserved gate region; other site 768494011843 putative PBP binding loops; other site 768494011844 ABC-ATPase subunit interface; other site 768494011845 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 768494011846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494011847 dimer interface [polypeptide binding]; other site 768494011848 conserved gate region; other site 768494011849 putative PBP binding loops; other site 768494011850 ABC-ATPase subunit interface; other site 768494011851 PBP superfamily domain; Region: PBP_like_2; cl17296 768494011852 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 768494011853 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768494011854 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494011855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494011856 putative substrate translocation pore; other site 768494011857 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494011858 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 768494011859 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 768494011860 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 768494011861 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 768494011862 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 768494011863 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768494011864 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768494011865 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768494011866 metal binding site 2 [ion binding]; metal-binding site 768494011867 putative DNA binding helix; other site 768494011868 metal binding site 1 [ion binding]; metal-binding site 768494011869 dimer interface [polypeptide binding]; other site 768494011870 structural Zn2+ binding site [ion binding]; other site 768494011871 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768494011872 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494011873 ABC-ATPase subunit interface; other site 768494011874 dimer interface [polypeptide binding]; other site 768494011875 putative PBP binding regions; other site 768494011876 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 768494011877 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768494011878 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768494011879 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494011880 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768494011881 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 768494011882 endonuclease IV; Provisional; Region: PRK01060 768494011883 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 768494011884 AP (apurinic/apyrimidinic) site pocket; other site 768494011885 DNA interaction; other site 768494011886 Metal-binding active site; metal-binding site 768494011887 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768494011888 DEAD-like helicases superfamily; Region: DEXDc; smart00487 768494011889 ATP binding site [chemical binding]; other site 768494011890 Mg++ binding site [ion binding]; other site 768494011891 motif III; other site 768494011892 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494011893 nucleotide binding region [chemical binding]; other site 768494011894 ATP-binding site [chemical binding]; other site 768494011895 YqfQ-like protein; Region: YqfQ; pfam14181 768494011896 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 768494011897 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 768494011898 Uncharacterized conserved protein [Function unknown]; Region: COG0327 768494011899 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 768494011900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 768494011901 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 768494011902 Uncharacterized conserved protein [Function unknown]; Region: COG0327 768494011903 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 768494011904 Family of unknown function (DUF633); Region: DUF633; pfam04816 768494011905 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768494011906 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768494011907 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 768494011908 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 768494011909 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768494011910 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494011911 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768494011912 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494011913 DNA binding residues [nucleotide binding] 768494011914 DNA primase; Validated; Region: dnaG; PRK05667 768494011915 CHC2 zinc finger; Region: zf-CHC2; pfam01807 768494011916 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 768494011917 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 768494011918 active site 768494011919 metal binding site [ion binding]; metal-binding site 768494011920 interdomain interaction site; other site 768494011921 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 768494011922 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 768494011923 PEP synthetase regulatory protein; Provisional; Region: PRK05339 768494011924 HTH domain; Region: HTH_11; pfam08279 768494011925 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 768494011926 FOG: CBS domain [General function prediction only]; Region: COG0517 768494011927 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 768494011928 Recombination protein O N terminal; Region: RecO_N; pfam11967 768494011929 Recombination protein O C terminal; Region: RecO_C; pfam02565 768494011930 YqzL-like protein; Region: YqzL; pfam14006 768494011931 GTPase Era; Reviewed; Region: era; PRK00089 768494011932 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 768494011933 G1 box; other site 768494011934 GTP/Mg2+ binding site [chemical binding]; other site 768494011935 Switch I region; other site 768494011936 G2 box; other site 768494011937 Switch II region; other site 768494011938 G3 box; other site 768494011939 G4 box; other site 768494011940 G5 box; other site 768494011941 KH domain; Region: KH_2; pfam07650 768494011942 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768494011943 active site 768494011944 catalytic motif [active] 768494011945 Zn binding site [ion binding]; other site 768494011946 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 768494011947 metal-binding heat shock protein; Provisional; Region: PRK00016 768494011948 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 768494011949 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 768494011950 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768494011951 Zn2+ binding site [ion binding]; other site 768494011952 Mg2+ binding site [ion binding]; other site 768494011953 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 768494011954 PhoH-like protein; Region: PhoH; pfam02562 768494011955 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 768494011956 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 768494011957 YabP family; Region: YabP; cl06766 768494011958 Yqey-like protein; Region: YqeY; pfam09424 768494011959 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 768494011960 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 768494011961 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 768494011962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494011963 FeS/SAM binding site; other site 768494011964 TRAM domain; Region: TRAM; cl01282 768494011965 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 768494011966 RNA methyltransferase, RsmE family; Region: TIGR00046 768494011967 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 768494011968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494011969 S-adenosylmethionine binding site [chemical binding]; other site 768494011970 chaperone protein DnaJ; Provisional; Region: PRK14280 768494011971 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768494011972 HSP70 interaction site [polypeptide binding]; other site 768494011973 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 768494011974 substrate binding site [polypeptide binding]; other site 768494011975 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 768494011976 Zn binding sites [ion binding]; other site 768494011977 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768494011978 dimer interface [polypeptide binding]; other site 768494011979 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 768494011980 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 768494011981 nucleotide binding site [chemical binding]; other site 768494011982 NEF interaction site [polypeptide binding]; other site 768494011983 SBD interface [polypeptide binding]; other site 768494011984 GrpE; Region: GrpE; pfam01025 768494011985 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 768494011986 dimer interface [polypeptide binding]; other site 768494011987 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 768494011988 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 768494011989 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 768494011990 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 768494011991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494011992 FeS/SAM binding site; other site 768494011993 HemN C-terminal domain; Region: HemN_C; pfam06969 768494011994 Predicted transcriptional regulators [Transcription]; Region: COG1733 768494011995 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768494011996 GTP-binding protein LepA; Provisional; Region: PRK05433 768494011997 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 768494011998 G1 box; other site 768494011999 putative GEF interaction site [polypeptide binding]; other site 768494012000 GTP/Mg2+ binding site [chemical binding]; other site 768494012001 Switch I region; other site 768494012002 G2 box; other site 768494012003 G3 box; other site 768494012004 Switch II region; other site 768494012005 G4 box; other site 768494012006 G5 box; other site 768494012007 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 768494012008 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 768494012009 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 768494012010 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 768494012011 germination protease; Provisional; Region: PRK02858 768494012012 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 768494012013 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 768494012014 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 768494012015 YqzM-like protein; Region: YqzM; pfam14141 768494012016 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 768494012017 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 768494012018 Competence protein; Region: Competence; pfam03772 768494012019 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494012020 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 768494012021 catalytic motif [active] 768494012022 Zn binding site [ion binding]; other site 768494012023 SLBB domain; Region: SLBB; pfam10531 768494012024 comEA protein; Region: comE; TIGR01259 768494012025 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 768494012026 late competence protein ComER; Validated; Region: PRK07680 768494012027 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768494012028 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 768494012029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494012030 S-adenosylmethionine binding site [chemical binding]; other site 768494012031 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 768494012032 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768494012033 Zn2+ binding site [ion binding]; other site 768494012034 Mg2+ binding site [ion binding]; other site 768494012035 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 768494012036 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 768494012037 active site 768494012038 (T/H)XGH motif; other site 768494012039 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 768494012040 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 768494012041 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768494012042 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768494012043 shikimate binding site; other site 768494012044 NAD(P) binding site [chemical binding]; other site 768494012045 GTPase YqeH; Provisional; Region: PRK13796 768494012046 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 768494012047 GTP/Mg2+ binding site [chemical binding]; other site 768494012048 G4 box; other site 768494012049 G5 box; other site 768494012050 G1 box; other site 768494012051 Switch I region; other site 768494012052 G2 box; other site 768494012053 G3 box; other site 768494012054 Switch II region; other site 768494012055 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 768494012056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494012057 active site 768494012058 motif I; other site 768494012059 motif II; other site 768494012060 Sporulation inhibitor A; Region: Sda; pfam08970 768494012061 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 768494012062 sporulation sigma factor SigK; Reviewed; Region: PRK05803 768494012063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494012064 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494012065 DNA binding residues [nucleotide binding] 768494012066 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 768494012067 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 768494012068 dimer interface [polypeptide binding]; other site 768494012069 FMN binding site [chemical binding]; other site 768494012070 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768494012071 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768494012072 synthetase active site [active] 768494012073 NTP binding site [chemical binding]; other site 768494012074 metal binding site [ion binding]; metal-binding site 768494012075 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 768494012076 dimer interface [polypeptide binding]; other site 768494012077 Alkaline phosphatase homologues; Region: alkPPc; smart00098 768494012078 active site 768494012079 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768494012080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494012081 Coenzyme A binding pocket [chemical binding]; other site 768494012082 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 768494012083 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768494012084 DoxX; Region: DoxX; cl17842 768494012085 CHAT domain; Region: CHAT; cl17868 768494012086 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 768494012087 catalytic core [active] 768494012088 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 768494012089 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 768494012090 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 768494012091 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 768494012092 putative active site [active] 768494012093 catalytic triad [active] 768494012094 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 768494012095 putative integrin binding motif; other site 768494012096 PA/protease domain interface [polypeptide binding]; other site 768494012097 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 768494012098 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 768494012099 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 768494012100 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 768494012101 cofactor binding site; other site 768494012102 metal binding site [ion binding]; metal-binding site 768494012103 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 768494012104 aromatic arch; other site 768494012105 DCoH dimer interaction site [polypeptide binding]; other site 768494012106 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 768494012107 DCoH tetramer interaction site [polypeptide binding]; other site 768494012108 substrate binding site [chemical binding]; other site 768494012109 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768494012110 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494012111 active site 768494012112 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 768494012113 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494012114 putative metal binding site [ion binding]; other site 768494012115 Predicted membrane protein [Function unknown]; Region: COG2259 768494012116 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768494012117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494012118 non-specific DNA binding site [nucleotide binding]; other site 768494012119 salt bridge; other site 768494012120 sequence-specific DNA binding site [nucleotide binding]; other site 768494012121 Cupin domain; Region: Cupin_2; pfam07883 768494012122 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 768494012123 dimer interaction site [polypeptide binding]; other site 768494012124 substrate-binding tunnel; other site 768494012125 active site 768494012126 catalytic site [active] 768494012127 substrate binding site [chemical binding]; other site 768494012128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494012129 Coenzyme A binding pocket [chemical binding]; other site 768494012130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494012131 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768494012132 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 768494012133 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768494012134 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768494012135 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768494012136 Walker A/P-loop; other site 768494012137 ATP binding site [chemical binding]; other site 768494012138 Q-loop/lid; other site 768494012139 ABC transporter signature motif; other site 768494012140 Walker B; other site 768494012141 D-loop; other site 768494012142 H-loop/switch region; other site 768494012143 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768494012144 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494012145 ABC-ATPase subunit interface; other site 768494012146 dimer interface [polypeptide binding]; other site 768494012147 putative PBP binding regions; other site 768494012148 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768494012149 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768494012150 intersubunit interface [polypeptide binding]; other site 768494012151 YrhC-like protein; Region: YrhC; pfam14143 768494012152 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 768494012153 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 768494012154 putative catalytic cysteine [active] 768494012155 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 768494012156 putative active site [active] 768494012157 metal binding site [ion binding]; metal-binding site 768494012158 cystathionine beta-lyase; Provisional; Region: PRK07671 768494012159 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768494012160 homodimer interface [polypeptide binding]; other site 768494012161 substrate-cofactor binding pocket; other site 768494012162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494012163 catalytic residue [active] 768494012164 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768494012165 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768494012166 dimer interface [polypeptide binding]; other site 768494012167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494012168 catalytic residue [active] 768494012169 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 768494012170 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 768494012171 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768494012172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494012173 S-adenosylmethionine binding site [chemical binding]; other site 768494012174 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 768494012175 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 768494012176 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 768494012177 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768494012178 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494012179 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 768494012180 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768494012181 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768494012182 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 768494012183 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 768494012184 ATP-binding site [chemical binding]; other site 768494012185 Sugar specificity; other site 768494012186 Pyrimidine base specificity; other site 768494012187 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768494012188 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768494012189 Peptidase family U32; Region: Peptidase_U32; pfam01136 768494012190 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768494012191 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 768494012192 Peptidase family U32; Region: Peptidase_U32; pfam01136 768494012193 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 768494012194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494012195 S-adenosylmethionine binding site [chemical binding]; other site 768494012196 YceG-like family; Region: YceG; pfam02618 768494012197 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 768494012198 dimerization interface [polypeptide binding]; other site 768494012199 hypothetical protein; Provisional; Region: PRK13678 768494012200 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 768494012201 hypothetical protein; Provisional; Region: PRK05473 768494012202 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 768494012203 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 768494012204 motif 1; other site 768494012205 active site 768494012206 motif 2; other site 768494012207 motif 3; other site 768494012208 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768494012209 DHHA1 domain; Region: DHHA1; pfam02272 768494012210 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768494012211 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768494012212 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 768494012213 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 768494012214 AAA domain; Region: AAA_30; pfam13604 768494012215 Family description; Region: UvrD_C_2; pfam13538 768494012216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494012217 TPR motif; other site 768494012218 TPR repeat; Region: TPR_11; pfam13414 768494012219 binding surface 768494012220 TPR repeat; Region: TPR_11; pfam13414 768494012221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494012222 binding surface 768494012223 TPR motif; other site 768494012224 TPR repeat; Region: TPR_11; pfam13414 768494012225 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 768494012226 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 768494012227 Ligand Binding Site [chemical binding]; other site 768494012228 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 768494012229 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 768494012230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768494012231 catalytic residue [active] 768494012232 Predicted transcriptional regulator [Transcription]; Region: COG1959 768494012233 Transcriptional regulator; Region: Rrf2; pfam02082 768494012234 recombination factor protein RarA; Reviewed; Region: PRK13342 768494012235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494012236 Walker A motif; other site 768494012237 ATP binding site [chemical binding]; other site 768494012238 Walker B motif; other site 768494012239 arginine finger; other site 768494012240 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 768494012241 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 768494012242 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 768494012243 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 768494012244 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 768494012245 putative ATP binding site [chemical binding]; other site 768494012246 putative substrate interface [chemical binding]; other site 768494012247 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 768494012248 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 768494012249 dimer interface [polypeptide binding]; other site 768494012250 anticodon binding site; other site 768494012251 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 768494012252 homodimer interface [polypeptide binding]; other site 768494012253 motif 1; other site 768494012254 active site 768494012255 motif 2; other site 768494012256 GAD domain; Region: GAD; pfam02938 768494012257 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 768494012258 motif 3; other site 768494012259 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 768494012260 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 768494012261 dimer interface [polypeptide binding]; other site 768494012262 motif 1; other site 768494012263 active site 768494012264 motif 2; other site 768494012265 motif 3; other site 768494012266 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 768494012267 anticodon binding site; other site 768494012268 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 768494012269 putative active site [active] 768494012270 dimerization interface [polypeptide binding]; other site 768494012271 putative tRNAtyr binding site [nucleotide binding]; other site 768494012272 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768494012273 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768494012274 Zn2+ binding site [ion binding]; other site 768494012275 Mg2+ binding site [ion binding]; other site 768494012276 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768494012277 synthetase active site [active] 768494012278 NTP binding site [chemical binding]; other site 768494012279 metal binding site [ion binding]; metal-binding site 768494012280 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768494012281 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768494012282 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768494012283 active site 768494012284 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 768494012285 DHH family; Region: DHH; pfam01368 768494012286 DHHA1 domain; Region: DHHA1; pfam02272 768494012287 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 768494012288 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768494012289 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 768494012290 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 768494012291 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768494012292 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 768494012293 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768494012294 Protein export membrane protein; Region: SecD_SecF; pfam02355 768494012295 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 768494012296 stage V sporulation protein B; Region: spore_V_B; TIGR02900 768494012297 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 768494012298 Predicted membrane protein [Function unknown]; Region: COG2323 768494012299 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 768494012300 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 768494012301 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 768494012302 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 768494012303 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 768494012304 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 768494012305 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 768494012306 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 768494012307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494012308 Walker A motif; other site 768494012309 ATP binding site [chemical binding]; other site 768494012310 Walker B motif; other site 768494012311 arginine finger; other site 768494012312 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 768494012313 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 768494012314 RuvA N terminal domain; Region: RuvA_N; pfam01330 768494012315 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 768494012316 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768494012317 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 768494012318 putative ligand binding residues [chemical binding]; other site 768494012319 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 768494012320 BofC C-terminal domain; Region: BofC_C; pfam08955 768494012321 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768494012322 EamA-like transporter family; Region: EamA; pfam00892 768494012323 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768494012324 EamA-like transporter family; Region: EamA; pfam00892 768494012325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494012326 dimerization interface [polypeptide binding]; other site 768494012327 putative DNA binding site [nucleotide binding]; other site 768494012328 putative Zn2+ binding site [ion binding]; other site 768494012329 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 768494012330 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768494012331 quinolinate synthetase; Provisional; Region: PRK09375 768494012332 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 768494012333 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 768494012334 dimerization interface [polypeptide binding]; other site 768494012335 active site 768494012336 L-aspartate oxidase; Provisional; Region: PRK08071 768494012337 L-aspartate oxidase; Provisional; Region: PRK06175 768494012338 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768494012339 cysteine desulfurase; Provisional; Region: PRK02948 768494012340 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 768494012341 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768494012342 catalytic residue [active] 768494012343 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 768494012344 HTH domain; Region: HTH_11; pfam08279 768494012345 3H domain; Region: 3H; pfam02829 768494012346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 768494012347 MOSC domain; Region: MOSC; pfam03473 768494012348 3-alpha domain; Region: 3-alpha; pfam03475 768494012349 prephenate dehydratase; Provisional; Region: PRK11898 768494012350 Prephenate dehydratase; Region: PDT; pfam00800 768494012351 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 768494012352 putative L-Phe binding site [chemical binding]; other site 768494012353 FtsX-like permease family; Region: FtsX; pfam02687 768494012354 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768494012355 FtsX-like permease family; Region: FtsX; pfam02687 768494012356 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768494012357 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768494012358 Walker A/P-loop; other site 768494012359 ATP binding site [chemical binding]; other site 768494012360 Q-loop/lid; other site 768494012361 ABC transporter signature motif; other site 768494012362 Walker B; other site 768494012363 D-loop; other site 768494012364 H-loop/switch region; other site 768494012365 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494012366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 768494012367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494012368 ATP binding site [chemical binding]; other site 768494012369 Mg2+ binding site [ion binding]; other site 768494012370 G-X-G motif; other site 768494012371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494012372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494012373 active site 768494012374 phosphorylation site [posttranslational modification] 768494012375 intermolecular recognition site; other site 768494012376 dimerization interface [polypeptide binding]; other site 768494012377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494012378 DNA binding site [nucleotide binding] 768494012379 GTPase CgtA; Reviewed; Region: obgE; PRK12297 768494012380 GTP1/OBG; Region: GTP1_OBG; pfam01018 768494012381 Obg GTPase; Region: Obg; cd01898 768494012382 G1 box; other site 768494012383 GTP/Mg2+ binding site [chemical binding]; other site 768494012384 Switch I region; other site 768494012385 G2 box; other site 768494012386 G3 box; other site 768494012387 Switch II region; other site 768494012388 G4 box; other site 768494012389 G5 box; other site 768494012390 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 768494012391 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 768494012392 hypothetical protein; Provisional; Region: PRK14553 768494012393 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 768494012394 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 768494012395 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 768494012396 homodimer interface [polypeptide binding]; other site 768494012397 oligonucleotide binding site [chemical binding]; other site 768494012398 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 768494012399 Peptidase family M50; Region: Peptidase_M50; pfam02163 768494012400 active site 768494012401 putative substrate binding region [chemical binding]; other site 768494012402 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 768494012403 Peptidase family M23; Region: Peptidase_M23; pfam01551 768494012404 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 768494012405 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 768494012406 Switch I; other site 768494012407 Switch II; other site 768494012408 septum formation inhibitor; Reviewed; Region: minC; PRK00513 768494012409 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 768494012410 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 768494012411 rod shape-determining protein MreC; Provisional; Region: PRK13922 768494012412 rod shape-determining protein MreC; Region: MreC; pfam04085 768494012413 rod shape-determining protein MreB; Provisional; Region: PRK13927 768494012414 MreB and similar proteins; Region: MreB_like; cd10225 768494012415 nucleotide binding site [chemical binding]; other site 768494012416 Mg binding site [ion binding]; other site 768494012417 putative protofilament interaction site [polypeptide binding]; other site 768494012418 RodZ interaction site [polypeptide binding]; other site 768494012419 hypothetical protein; Reviewed; Region: PRK00024 768494012420 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 768494012421 MPN+ (JAMM) motif; other site 768494012422 Zinc-binding site [ion binding]; other site 768494012423 Maf-like protein; Region: Maf; pfam02545 768494012424 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768494012425 active site 768494012426 dimer interface [polypeptide binding]; other site 768494012427 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 768494012428 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768494012429 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768494012430 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 768494012431 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768494012432 active site 768494012433 HIGH motif; other site 768494012434 nucleotide binding site [chemical binding]; other site 768494012435 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768494012436 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768494012437 active site 768494012438 KMSKS motif; other site 768494012439 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 768494012440 tRNA binding surface [nucleotide binding]; other site 768494012441 anticodon binding site; other site 768494012442 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 768494012443 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 768494012444 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 768494012445 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768494012446 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 768494012447 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768494012448 inhibitor-cofactor binding pocket; inhibition site 768494012449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494012450 catalytic residue [active] 768494012451 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 768494012452 dimer interface [polypeptide binding]; other site 768494012453 active site 768494012454 Schiff base residues; other site 768494012455 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 768494012456 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 768494012457 active site 768494012458 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 768494012459 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 768494012460 domain interfaces; other site 768494012461 active site 768494012462 potential frameshift: common BLAST hit: gi|384182284|ref|YP_005568046.1| membrane-bound protein HemX 768494012463 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 768494012464 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 768494012465 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 768494012466 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 768494012467 tRNA; other site 768494012468 putative tRNA binding site [nucleotide binding]; other site 768494012469 putative NADP binding site [chemical binding]; other site 768494012470 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 768494012471 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768494012472 MarR family; Region: MarR; pfam01047 768494012473 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 768494012474 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 768494012475 G1 box; other site 768494012476 GTP/Mg2+ binding site [chemical binding]; other site 768494012477 Switch I region; other site 768494012478 G2 box; other site 768494012479 G3 box; other site 768494012480 Switch II region; other site 768494012481 G4 box; other site 768494012482 G5 box; other site 768494012483 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 768494012484 Found in ATP-dependent protease La (LON); Region: LON; smart00464 768494012485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494012486 Walker A motif; other site 768494012487 ATP binding site [chemical binding]; other site 768494012488 Walker B motif; other site 768494012489 arginine finger; other site 768494012490 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768494012491 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 768494012492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494012493 Walker A motif; other site 768494012494 ATP binding site [chemical binding]; other site 768494012495 Walker B motif; other site 768494012496 arginine finger; other site 768494012497 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768494012498 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 768494012499 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 768494012500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494012501 Walker A motif; other site 768494012502 ATP binding site [chemical binding]; other site 768494012503 Walker B motif; other site 768494012504 arginine finger; other site 768494012505 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768494012506 trigger factor; Provisional; Region: tig; PRK01490 768494012507 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768494012508 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 768494012509 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 768494012510 pentamer interface [polypeptide binding]; other site 768494012511 dodecaamer interface [polypeptide binding]; other site 768494012512 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 768494012513 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 768494012514 active site 768494012515 metal binding site [ion binding]; metal-binding site 768494012516 homotetramer interface [polypeptide binding]; other site 768494012517 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 768494012518 active site 768494012519 dimerization interface [polypeptide binding]; other site 768494012520 ribonuclease PH; Reviewed; Region: rph; PRK00173 768494012521 Ribonuclease PH; Region: RNase_PH_bact; cd11362 768494012522 hexamer interface [polypeptide binding]; other site 768494012523 active site 768494012524 Sporulation and spore germination; Region: Germane; pfam10646 768494012525 Spore germination protein [General function prediction only]; Region: COG5401 768494012526 Sporulation and spore germination; Region: Germane; pfam10646 768494012527 glutamate racemase; Provisional; Region: PRK00865 768494012528 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768494012529 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 768494012530 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 768494012531 potential catalytic triad [active] 768494012532 conserved cys residue [active] 768494012533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494012534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494012535 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 768494012536 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 768494012537 potential catalytic triad [active] 768494012538 conserved cys residue [active] 768494012539 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768494012540 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768494012541 DNA binding residues [nucleotide binding] 768494012542 dimerization interface [polypeptide binding]; other site 768494012543 putative uracil/xanthine transporter; Provisional; Region: PRK11412 768494012544 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768494012545 EamA-like transporter family; Region: EamA; pfam00892 768494012546 EamA-like transporter family; Region: EamA; pfam00892 768494012547 putative deaminase; Validated; Region: PRK06846 768494012548 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 768494012549 active site 768494012550 putative deaminase; Validated; Region: PRK06846 768494012551 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 768494012552 active site 768494012553 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768494012554 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 768494012555 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 768494012556 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768494012557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494012558 dimer interface [polypeptide binding]; other site 768494012559 conserved gate region; other site 768494012560 ABC-ATPase subunit interface; other site 768494012561 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768494012562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494012563 dimer interface [polypeptide binding]; other site 768494012564 conserved gate region; other site 768494012565 putative PBP binding loops; other site 768494012566 ABC-ATPase subunit interface; other site 768494012567 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768494012568 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768494012569 Walker A/P-loop; other site 768494012570 ATP binding site [chemical binding]; other site 768494012571 Q-loop/lid; other site 768494012572 ABC transporter signature motif; other site 768494012573 Walker B; other site 768494012574 D-loop; other site 768494012575 H-loop/switch region; other site 768494012576 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768494012577 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 768494012578 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768494012579 Walker A/P-loop; other site 768494012580 ATP binding site [chemical binding]; other site 768494012581 Q-loop/lid; other site 768494012582 ABC transporter signature motif; other site 768494012583 Walker B; other site 768494012584 D-loop; other site 768494012585 H-loop/switch region; other site 768494012586 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768494012587 Histidine kinase; Region: His_kinase; pfam06580 768494012588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494012589 Response regulator receiver domain; Region: Response_reg; pfam00072 768494012590 active site 768494012591 phosphorylation site [posttranslational modification] 768494012592 intermolecular recognition site; other site 768494012593 dimerization interface [polypeptide binding]; other site 768494012594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494012595 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768494012596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494012597 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 768494012598 PspC domain; Region: PspC; pfam04024 768494012599 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768494012600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494012601 non-specific DNA binding site [nucleotide binding]; other site 768494012602 salt bridge; other site 768494012603 sequence-specific DNA binding site [nucleotide binding]; other site 768494012604 Cupin domain; Region: Cupin_2; pfam07883 768494012605 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 768494012606 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 768494012607 amphipathic channel; other site 768494012608 Asn-Pro-Ala signature motifs; other site 768494012609 Predicted transcriptional regulator [Transcription]; Region: COG1959 768494012610 Transcriptional regulator; Region: Rrf2; pfam02082 768494012611 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 768494012612 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 768494012613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494012614 Walker A/P-loop; other site 768494012615 ATP binding site [chemical binding]; other site 768494012616 Q-loop/lid; other site 768494012617 ABC transporter signature motif; other site 768494012618 Walker B; other site 768494012619 D-loop; other site 768494012620 H-loop/switch region; other site 768494012621 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 768494012622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494012623 active site 768494012624 motif I; other site 768494012625 motif II; other site 768494012626 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768494012627 ligand binding site [chemical binding]; other site 768494012628 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 768494012629 flagellar motor protein MotA; Validated; Region: PRK08124 768494012630 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 768494012631 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 768494012632 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 768494012633 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768494012634 active site 768494012635 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 768494012636 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 768494012637 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768494012638 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 768494012639 L-aspartate oxidase; Provisional; Region: PRK06175 768494012640 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768494012641 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 768494012642 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 768494012643 putative Iron-sulfur protein interface [polypeptide binding]; other site 768494012644 proximal heme binding site [chemical binding]; other site 768494012645 distal heme binding site [chemical binding]; other site 768494012646 putative dimer interface [polypeptide binding]; other site 768494012647 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 768494012648 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 768494012649 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768494012650 GIY-YIG motif/motif A; other site 768494012651 active site 768494012652 catalytic site [active] 768494012653 putative DNA binding site [nucleotide binding]; other site 768494012654 metal binding site [ion binding]; metal-binding site 768494012655 UvrB/uvrC motif; Region: UVR; pfam02151 768494012656 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 768494012657 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768494012658 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768494012659 catalytic residues [active] 768494012660 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 768494012661 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 768494012662 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 768494012663 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 768494012664 Electron transfer flavoprotein domain; Region: ETF; pfam01012 768494012665 Ligand binding site [chemical binding]; other site 768494012666 enoyl-CoA hydratase; Provisional; Region: PRK07658 768494012667 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768494012668 substrate binding site [chemical binding]; other site 768494012669 oxyanion hole (OAH) forming residues; other site 768494012670 trimer interface [polypeptide binding]; other site 768494012671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 768494012672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494012673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494012674 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 768494012675 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 768494012676 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 768494012677 acyl-activating enzyme (AAE) consensus motif; other site 768494012678 putative AMP binding site [chemical binding]; other site 768494012679 putative active site [active] 768494012680 putative CoA binding site [chemical binding]; other site 768494012681 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 768494012682 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768494012683 siderophore binding site; other site 768494012684 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768494012685 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494012686 ABC-ATPase subunit interface; other site 768494012687 dimer interface [polypeptide binding]; other site 768494012688 putative PBP binding regions; other site 768494012689 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494012690 ABC-ATPase subunit interface; other site 768494012691 dimer interface [polypeptide binding]; other site 768494012692 putative PBP binding regions; other site 768494012693 DinB family; Region: DinB; cl17821 768494012694 DinB superfamily; Region: DinB_2; pfam12867 768494012695 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 768494012696 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 768494012697 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 768494012698 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494012699 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 768494012700 Walker A/P-loop; other site 768494012701 ATP binding site [chemical binding]; other site 768494012702 Q-loop/lid; other site 768494012703 ABC transporter signature motif; other site 768494012704 Walker B; other site 768494012705 D-loop; other site 768494012706 H-loop/switch region; other site 768494012707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494012708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494012709 dimer interface [polypeptide binding]; other site 768494012710 phosphorylation site [posttranslational modification] 768494012711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494012712 ATP binding site [chemical binding]; other site 768494012713 Mg2+ binding site [ion binding]; other site 768494012714 G-X-G motif; other site 768494012715 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494012716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494012717 active site 768494012718 phosphorylation site [posttranslational modification] 768494012719 intermolecular recognition site; other site 768494012720 dimerization interface [polypeptide binding]; other site 768494012721 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494012722 DNA binding site [nucleotide binding] 768494012723 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 768494012724 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 768494012725 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 768494012726 putative RNA binding site [nucleotide binding]; other site 768494012727 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 768494012728 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768494012729 TrkA-N domain; Region: TrkA_N; pfam02254 768494012730 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 768494012731 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 768494012732 active site 768494012733 catalytic site [active] 768494012734 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768494012735 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768494012736 Walker A/P-loop; other site 768494012737 ATP binding site [chemical binding]; other site 768494012738 Q-loop/lid; other site 768494012739 ABC transporter signature motif; other site 768494012740 Walker B; other site 768494012741 D-loop; other site 768494012742 H-loop/switch region; other site 768494012743 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 768494012744 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494012745 ABC-ATPase subunit interface; other site 768494012746 dimer interface [polypeptide binding]; other site 768494012747 putative PBP binding regions; other site 768494012748 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 768494012749 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768494012750 intersubunit interface [polypeptide binding]; other site 768494012751 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 768494012752 heme-binding site [chemical binding]; other site 768494012753 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 768494012754 heme-binding site [chemical binding]; other site 768494012755 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 768494012756 heme-binding site [chemical binding]; other site 768494012757 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 768494012758 heme-binding site [chemical binding]; other site 768494012759 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 768494012760 heme-binding site [chemical binding]; other site 768494012761 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 768494012762 heme-binding site [chemical binding]; other site 768494012763 heme uptake protein IsdC; Region: IsdC; TIGR03656 768494012764 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 768494012765 heme-binding site [chemical binding]; other site 768494012766 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 768494012767 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 768494012768 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 768494012769 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768494012770 RNA binding surface [nucleotide binding]; other site 768494012771 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 768494012772 probable active site [active] 768494012773 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 768494012774 MutS domain III; Region: MutS_III; pfam05192 768494012775 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 768494012776 Walker A/P-loop; other site 768494012777 ATP binding site [chemical binding]; other site 768494012778 Q-loop/lid; other site 768494012779 ABC transporter signature motif; other site 768494012780 Walker B; other site 768494012781 D-loop; other site 768494012782 H-loop/switch region; other site 768494012783 Smr domain; Region: Smr; pfam01713 768494012784 hypothetical protein; Provisional; Region: PRK08609 768494012785 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 768494012786 active site 768494012787 primer binding site [nucleotide binding]; other site 768494012788 NTP binding site [chemical binding]; other site 768494012789 metal binding triad [ion binding]; metal-binding site 768494012790 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 768494012791 active site 768494012792 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 768494012793 Colicin V production protein; Region: Colicin_V; pfam02674 768494012794 Cell division protein ZapA; Region: ZapA; cl01146 768494012795 ribonuclease HIII; Provisional; Region: PRK00996 768494012796 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 768494012797 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 768494012798 RNA/DNA hybrid binding site [nucleotide binding]; other site 768494012799 active site 768494012800 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 768494012801 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 768494012802 putative dimer interface [polypeptide binding]; other site 768494012803 putative anticodon binding site; other site 768494012804 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 768494012805 homodimer interface [polypeptide binding]; other site 768494012806 motif 1; other site 768494012807 motif 2; other site 768494012808 active site 768494012809 motif 3; other site 768494012810 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 768494012811 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 768494012812 putative tRNA-binding site [nucleotide binding]; other site 768494012813 B3/4 domain; Region: B3_4; pfam03483 768494012814 tRNA synthetase B5 domain; Region: B5; smart00874 768494012815 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 768494012816 dimer interface [polypeptide binding]; other site 768494012817 motif 1; other site 768494012818 motif 3; other site 768494012819 motif 2; other site 768494012820 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 768494012821 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 768494012822 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 768494012823 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 768494012824 dimer interface [polypeptide binding]; other site 768494012825 motif 1; other site 768494012826 active site 768494012827 motif 2; other site 768494012828 motif 3; other site 768494012829 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 768494012830 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 768494012831 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768494012832 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 768494012833 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768494012834 Zn2+ binding site [ion binding]; other site 768494012835 Mg2+ binding site [ion binding]; other site 768494012836 CAAX protease self-immunity; Region: Abi; pfam02517 768494012837 CAAX protease self-immunity; Region: Abi; pfam02517 768494012838 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768494012839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494012840 putative substrate translocation pore; other site 768494012841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494012842 HlyD family secretion protein; Region: HlyD_3; pfam13437 768494012843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494012844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494012845 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 768494012846 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 768494012847 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 768494012848 oligomer interface [polypeptide binding]; other site 768494012849 active site 768494012850 metal binding site [ion binding]; metal-binding site 768494012851 dUTPase; Region: dUTPase_2; pfam08761 768494012852 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 768494012853 active site 768494012854 homodimer interface [polypeptide binding]; other site 768494012855 metal binding site [ion binding]; metal-binding site 768494012856 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 768494012857 23S rRNA binding site [nucleotide binding]; other site 768494012858 L21 binding site [polypeptide binding]; other site 768494012859 L13 binding site [polypeptide binding]; other site 768494012860 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 768494012861 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 768494012862 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 768494012863 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 768494012864 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 768494012865 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 768494012866 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768494012867 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 768494012868 active site 768494012869 dimer interface [polypeptide binding]; other site 768494012870 motif 1; other site 768494012871 motif 2; other site 768494012872 motif 3; other site 768494012873 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 768494012874 anticodon binding site; other site 768494012875 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 768494012876 primosomal protein DnaI; Reviewed; Region: PRK08939 768494012877 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 768494012878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494012879 Walker A motif; other site 768494012880 ATP binding site [chemical binding]; other site 768494012881 Walker B motif; other site 768494012882 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 768494012883 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 768494012884 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 768494012885 ATP cone domain; Region: ATP-cone; pfam03477 768494012886 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 768494012887 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 768494012888 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 768494012889 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768494012890 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 768494012891 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 768494012892 CoA-binding site [chemical binding]; other site 768494012893 ATP-binding [chemical binding]; other site 768494012894 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 768494012895 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 768494012896 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 768494012897 DNA binding site [nucleotide binding] 768494012898 catalytic residue [active] 768494012899 H2TH interface [polypeptide binding]; other site 768494012900 putative catalytic residues [active] 768494012901 turnover-facilitating residue; other site 768494012902 intercalation triad [nucleotide binding]; other site 768494012903 8OG recognition residue [nucleotide binding]; other site 768494012904 putative reading head residues; other site 768494012905 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 768494012906 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768494012907 DNA polymerase I; Provisional; Region: PRK05755 768494012908 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768494012909 active site 768494012910 metal binding site 1 [ion binding]; metal-binding site 768494012911 putative 5' ssDNA interaction site; other site 768494012912 metal binding site 3; metal-binding site 768494012913 metal binding site 2 [ion binding]; metal-binding site 768494012914 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768494012915 putative DNA binding site [nucleotide binding]; other site 768494012916 putative metal binding site [ion binding]; other site 768494012917 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 768494012918 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 768494012919 active site 768494012920 DNA binding site [nucleotide binding] 768494012921 catalytic site [active] 768494012922 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494012923 dimerization interface [polypeptide binding]; other site 768494012924 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 768494012925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494012926 putative active site [active] 768494012927 heme pocket [chemical binding]; other site 768494012928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494012929 dimer interface [polypeptide binding]; other site 768494012930 phosphorylation site [posttranslational modification] 768494012931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494012932 ATP binding site [chemical binding]; other site 768494012933 Mg2+ binding site [ion binding]; other site 768494012934 G-X-G motif; other site 768494012935 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494012936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494012937 active site 768494012938 phosphorylation site [posttranslational modification] 768494012939 intermolecular recognition site; other site 768494012940 dimerization interface [polypeptide binding]; other site 768494012941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494012942 DNA binding site [nucleotide binding] 768494012943 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768494012944 active site 2 [active] 768494012945 active site 1 [active] 768494012946 malate dehydrogenase; Reviewed; Region: PRK06223 768494012947 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 768494012948 NAD(P) binding site [chemical binding]; other site 768494012949 dimer interface [polypeptide binding]; other site 768494012950 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768494012951 substrate binding site [chemical binding]; other site 768494012952 isocitrate dehydrogenase; Reviewed; Region: PRK07006 768494012953 isocitrate dehydrogenase; Validated; Region: PRK07362 768494012954 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 768494012955 dimer interface [polypeptide binding]; other site 768494012956 Citrate synthase; Region: Citrate_synt; pfam00285 768494012957 active site 768494012958 citrylCoA binding site [chemical binding]; other site 768494012959 oxalacetate/citrate binding site [chemical binding]; other site 768494012960 coenzyme A binding site [chemical binding]; other site 768494012961 catalytic triad [active] 768494012962 Protein of unknown function (DUF441); Region: DUF441; pfam04284 768494012963 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 768494012964 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768494012965 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 768494012966 pyruvate kinase; Provisional; Region: PRK06354 768494012967 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 768494012968 domain interfaces; other site 768494012969 active site 768494012970 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 768494012971 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 768494012972 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 768494012973 active site 768494012974 ADP/pyrophosphate binding site [chemical binding]; other site 768494012975 dimerization interface [polypeptide binding]; other site 768494012976 allosteric effector site; other site 768494012977 fructose-1,6-bisphosphate binding site; other site 768494012978 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 768494012979 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 768494012980 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 768494012981 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 768494012982 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 768494012983 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768494012984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494012985 DNA-binding site [nucleotide binding]; DNA binding site 768494012986 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 768494012987 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768494012988 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 768494012989 putative NAD(P) binding site [chemical binding]; other site 768494012990 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 768494012991 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 768494012992 active site 768494012993 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 768494012994 generic binding surface II; other site 768494012995 generic binding surface I; other site 768494012996 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 768494012997 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 768494012998 DHH family; Region: DHH; pfam01368 768494012999 DHHA1 domain; Region: DHHA1; pfam02272 768494013000 YtpI-like protein; Region: YtpI; pfam14007 768494013001 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 768494013002 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 768494013003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494013004 DNA-binding site [nucleotide binding]; DNA binding site 768494013005 DRTGG domain; Region: DRTGG; pfam07085 768494013006 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 768494013007 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 768494013008 active site 2 [active] 768494013009 active site 1 [active] 768494013010 metal-dependent hydrolase; Provisional; Region: PRK00685 768494013011 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 768494013012 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768494013013 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768494013014 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 768494013015 active site 768494013016 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 768494013017 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 768494013018 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768494013019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494013020 Coenzyme A binding pocket [chemical binding]; other site 768494013021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768494013022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494013023 Coenzyme A binding pocket [chemical binding]; other site 768494013024 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 768494013025 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494013026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494013027 non-specific DNA binding site [nucleotide binding]; other site 768494013028 salt bridge; other site 768494013029 sequence-specific DNA binding site [nucleotide binding]; other site 768494013030 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 768494013031 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 768494013032 hexamer interface [polypeptide binding]; other site 768494013033 ligand binding site [chemical binding]; other site 768494013034 putative active site [active] 768494013035 NAD(P) binding site [chemical binding]; other site 768494013036 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 768494013037 classical (c) SDRs; Region: SDR_c; cd05233 768494013038 NAD(P) binding site [chemical binding]; other site 768494013039 active site 768494013040 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768494013041 Ligand Binding Site [chemical binding]; other site 768494013042 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 768494013043 argininosuccinate lyase; Provisional; Region: PRK00855 768494013044 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 768494013045 active sites [active] 768494013046 tetramer interface [polypeptide binding]; other site 768494013047 argininosuccinate synthase; Provisional; Region: PRK13820 768494013048 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 768494013049 ANP binding site [chemical binding]; other site 768494013050 Substrate Binding Site II [chemical binding]; other site 768494013051 Substrate Binding Site I [chemical binding]; other site 768494013052 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768494013053 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494013054 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494013055 EcsC protein family; Region: EcsC; pfam12787 768494013056 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 768494013057 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 768494013058 nudix motif; other site 768494013059 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 768494013060 propionate/acetate kinase; Provisional; Region: PRK12379 768494013061 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 768494013062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494013063 S-adenosylmethionine binding site [chemical binding]; other site 768494013064 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 768494013065 dimer interface [polypeptide binding]; other site 768494013066 catalytic triad [active] 768494013067 peroxidatic and resolving cysteines [active] 768494013068 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 768494013069 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 768494013070 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 768494013071 ATP-NAD kinase; Region: NAD_kinase; pfam01513 768494013072 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 768494013073 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 768494013074 active site 768494013075 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494013076 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768494013077 dimer interface [polypeptide binding]; other site 768494013078 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 768494013079 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 768494013080 active site 768494013081 acyl-activating enzyme (AAE) consensus motif; other site 768494013082 putative CoA binding site [chemical binding]; other site 768494013083 AMP binding site [chemical binding]; other site 768494013084 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 768494013085 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 768494013086 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 768494013087 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 768494013088 Ligand Binding Site [chemical binding]; other site 768494013089 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 768494013090 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 768494013091 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768494013092 catalytic residue [active] 768494013093 septation ring formation regulator EzrA; Provisional; Region: PRK04778 768494013094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768494013095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494013096 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768494013097 dimerization interface [polypeptide binding]; other site 768494013098 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768494013099 EamA-like transporter family; Region: EamA; pfam00892 768494013100 EamA-like transporter family; Region: EamA; pfam00892 768494013101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494013102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494013103 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 768494013104 GAF domain; Region: GAF_2; pfam13185 768494013105 methionine gamma-lyase; Provisional; Region: PRK06767 768494013106 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768494013107 homodimer interface [polypeptide binding]; other site 768494013108 substrate-cofactor binding pocket; other site 768494013109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494013110 catalytic residue [active] 768494013111 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 768494013112 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 768494013113 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768494013114 RNA binding surface [nucleotide binding]; other site 768494013115 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 768494013116 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 768494013117 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 768494013118 active site 768494013119 HIGH motif; other site 768494013120 dimer interface [polypeptide binding]; other site 768494013121 KMSKS motif; other site 768494013122 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768494013123 RNA binding surface [nucleotide binding]; other site 768494013124 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 768494013125 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494013126 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494013127 DNA binding residues [nucleotide binding] 768494013128 acetyl-CoA synthetase; Provisional; Region: PRK04319 768494013129 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 768494013130 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 768494013131 active site 768494013132 acyl-activating enzyme (AAE) consensus motif; other site 768494013133 putative CoA binding site [chemical binding]; other site 768494013134 AMP binding site [chemical binding]; other site 768494013135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494013136 Coenzyme A binding pocket [chemical binding]; other site 768494013137 FOG: CBS domain [General function prediction only]; Region: COG0517 768494013138 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 768494013139 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 768494013140 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 768494013141 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 768494013142 active site 768494013143 Zn binding site [ion binding]; other site 768494013144 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494013145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494013146 active site 768494013147 phosphorylation site [posttranslational modification] 768494013148 intermolecular recognition site; other site 768494013149 dimerization interface [polypeptide binding]; other site 768494013150 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494013151 DNA binding site [nucleotide binding] 768494013152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494013153 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494013154 dimerization interface [polypeptide binding]; other site 768494013155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494013156 dimer interface [polypeptide binding]; other site 768494013157 phosphorylation site [posttranslational modification] 768494013158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494013159 ATP binding site [chemical binding]; other site 768494013160 Mg2+ binding site [ion binding]; other site 768494013161 G-X-G motif; other site 768494013162 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768494013163 Ankyrin repeat; Region: Ank; pfam00023 768494013164 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 768494013165 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 768494013166 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 768494013167 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768494013168 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768494013169 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 768494013170 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 768494013171 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 768494013172 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 768494013173 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 768494013174 catabolite control protein A; Region: ccpA; TIGR01481 768494013175 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768494013176 DNA binding site [nucleotide binding] 768494013177 domain linker motif; other site 768494013178 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 768494013179 dimerization interface [polypeptide binding]; other site 768494013180 effector binding site; other site 768494013181 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 768494013182 putative dimer interface [polypeptide binding]; other site 768494013183 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 768494013184 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 768494013185 putative dimer interface [polypeptide binding]; other site 768494013186 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 768494013187 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 768494013188 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 768494013189 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 768494013190 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 768494013191 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494013192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494013193 Coenzyme A binding pocket [chemical binding]; other site 768494013194 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 768494013195 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768494013196 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768494013197 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768494013198 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 768494013199 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 768494013200 active site 768494013201 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 768494013202 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768494013203 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 768494013204 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 768494013205 putative tRNA-binding site [nucleotide binding]; other site 768494013206 hypothetical protein; Provisional; Region: PRK13668 768494013207 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768494013208 catalytic residues [active] 768494013209 NTPase; Reviewed; Region: PRK03114 768494013210 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 768494013211 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 768494013212 oligomer interface [polypeptide binding]; other site 768494013213 active site 768494013214 metal binding site [ion binding]; metal-binding site 768494013215 Predicted small secreted protein [Function unknown]; Region: COG5584 768494013216 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494013217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494013218 S-adenosylmethionine binding site [chemical binding]; other site 768494013219 YtzH-like protein; Region: YtzH; pfam14165 768494013220 Phosphotransferase enzyme family; Region: APH; pfam01636 768494013221 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 768494013222 active site 768494013223 substrate binding site [chemical binding]; other site 768494013224 ATP binding site [chemical binding]; other site 768494013225 pullulanase, type I; Region: pulA_typeI; TIGR02104 768494013226 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 768494013227 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 768494013228 Ca binding site [ion binding]; other site 768494013229 active site 768494013230 catalytic site [active] 768494013231 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 768494013232 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 768494013233 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 768494013234 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 768494013235 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 768494013236 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 768494013237 active site 768494013238 metal binding site [ion binding]; metal-binding site 768494013239 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 768494013240 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 768494013241 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768494013242 RNA binding surface [nucleotide binding]; other site 768494013243 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 768494013244 active site 768494013245 uracil binding [chemical binding]; other site 768494013246 stage V sporulation protein B; Region: spore_V_B; TIGR02900 768494013247 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 768494013248 HI0933-like protein; Region: HI0933_like; pfam03486 768494013249 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768494013250 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768494013251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494013252 putative substrate translocation pore; other site 768494013253 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494013254 dimerization interface [polypeptide binding]; other site 768494013255 putative DNA binding site [nucleotide binding]; other site 768494013256 putative Zn2+ binding site [ion binding]; other site 768494013257 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 768494013258 putative hydrophobic ligand binding site [chemical binding]; other site 768494013259 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 768494013260 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 768494013261 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 768494013262 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 768494013263 glucose-1-dehydrogenase; Provisional; Region: PRK08936 768494013264 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 768494013265 NAD binding site [chemical binding]; other site 768494013266 homodimer interface [polypeptide binding]; other site 768494013267 active site 768494013268 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 768494013269 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 768494013270 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 768494013271 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 768494013272 MoaE interaction surface [polypeptide binding]; other site 768494013273 MoeB interaction surface [polypeptide binding]; other site 768494013274 thiocarboxylated glycine; other site 768494013275 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 768494013276 MoaE homodimer interface [polypeptide binding]; other site 768494013277 MoaD interaction [polypeptide binding]; other site 768494013278 active site residues [active] 768494013279 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768494013280 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 768494013281 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 768494013282 dimer interface [polypeptide binding]; other site 768494013283 putative functional site; other site 768494013284 putative MPT binding site; other site 768494013285 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 768494013286 trimer interface [polypeptide binding]; other site 768494013287 dimer interface [polypeptide binding]; other site 768494013288 putative active site [active] 768494013289 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 768494013290 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768494013291 ATP binding site [chemical binding]; other site 768494013292 substrate interface [chemical binding]; other site 768494013293 potential frameshift: common BLAST hit: gi|49478739|ref|YP_038771.1| molybdenum cofactor biosynthesis protein A 768494013294 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768494013295 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494013296 FeS/SAM binding site; other site 768494013297 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 768494013298 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768494013299 active site residue [active] 768494013300 homoserine O-acetyltransferase; Provisional; Region: PRK06765 768494013301 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 768494013302 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 768494013303 Spore germination protein; Region: Spore_permease; pfam03845 768494013304 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 768494013305 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 768494013306 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 768494013307 putative nucleotide binding site [chemical binding]; other site 768494013308 putative metal binding site [ion binding]; other site 768494013309 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 768494013310 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 768494013311 HIGH motif; other site 768494013312 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768494013313 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 768494013314 active site 768494013315 KMSKS motif; other site 768494013316 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 768494013317 tRNA binding surface [nucleotide binding]; other site 768494013318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494013319 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494013320 putative substrate translocation pore; other site 768494013321 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 768494013322 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768494013323 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 768494013324 TrkA-C domain; Region: TrkA_C; pfam02080 768494013325 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 768494013326 Int/Topo IB signature motif; other site 768494013327 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768494013328 FtsX-like permease family; Region: FtsX; pfam02687 768494013329 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768494013330 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768494013331 Walker A/P-loop; other site 768494013332 ATP binding site [chemical binding]; other site 768494013333 Q-loop/lid; other site 768494013334 ABC transporter signature motif; other site 768494013335 Walker B; other site 768494013336 D-loop; other site 768494013337 H-loop/switch region; other site 768494013338 Protein of unknown function (DUF418); Region: DUF418; cl12135 768494013339 Protein of unknown function (DUF418); Region: DUF418; pfam04235 768494013340 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 768494013341 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 768494013342 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494013343 FeS/SAM binding site; other site 768494013344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494013345 S-adenosylmethionine binding site [chemical binding]; other site 768494013346 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494013347 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494013348 Walker A/P-loop; other site 768494013349 ATP binding site [chemical binding]; other site 768494013350 Q-loop/lid; other site 768494013351 ABC transporter signature motif; other site 768494013352 Walker B; other site 768494013353 D-loop; other site 768494013354 H-loop/switch region; other site 768494013355 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768494013356 aspartate racemase; Region: asp_race; TIGR00035 768494013357 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 768494013358 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 768494013359 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 768494013360 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 768494013361 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768494013362 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768494013363 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 768494013364 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768494013365 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 768494013366 trimer interface [polypeptide binding]; other site 768494013367 putative metal binding site [ion binding]; other site 768494013368 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768494013369 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 768494013370 active site 768494013371 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768494013372 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 768494013373 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 768494013374 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 768494013375 GTP binding site; other site 768494013376 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 768494013377 MPT binding site; other site 768494013378 trimer interface [polypeptide binding]; other site 768494013379 S-adenosylmethionine synthetase; Validated; Region: PRK05250 768494013380 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 768494013381 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 768494013382 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 768494013383 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 768494013384 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 768494013385 active site 768494013386 substrate-binding site [chemical binding]; other site 768494013387 metal-binding site [ion binding] 768494013388 ATP binding site [chemical binding]; other site 768494013389 ATP synthase I chain; Region: ATP_synt_I; pfam03899 768494013390 EamA-like transporter family; Region: EamA; pfam00892 768494013391 EamA-like transporter family; Region: EamA; pfam00892 768494013392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 768494013393 Uncharacterized conserved protein [Function unknown]; Region: COG0327 768494013394 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 768494013395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494013396 ATP binding site [chemical binding]; other site 768494013397 Mg2+ binding site [ion binding]; other site 768494013398 G-X-G motif; other site 768494013399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494013400 dimer interface [polypeptide binding]; other site 768494013401 phosphorylation site [posttranslational modification] 768494013402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494013403 ATP binding site [chemical binding]; other site 768494013404 Mg2+ binding site [ion binding]; other site 768494013405 G-X-G motif; other site 768494013406 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 768494013407 Secretory lipase; Region: LIP; pfam03583 768494013408 Sulfatase; Region: Sulfatase; pfam00884 768494013409 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 768494013410 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768494013411 NMT1-like family; Region: NMT1_2; pfam13379 768494013412 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 768494013413 Walker A/P-loop; other site 768494013414 ATP binding site [chemical binding]; other site 768494013415 ABC transporter; Region: ABC_tran; pfam00005 768494013416 Q-loop/lid; other site 768494013417 ABC transporter signature motif; other site 768494013418 Walker B; other site 768494013419 D-loop; other site 768494013420 H-loop/switch region; other site 768494013421 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768494013422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494013423 dimer interface [polypeptide binding]; other site 768494013424 conserved gate region; other site 768494013425 putative PBP binding loops; other site 768494013426 ABC-ATPase subunit interface; other site 768494013427 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 768494013428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494013429 motif II; other site 768494013430 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 768494013431 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 768494013432 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 768494013433 nudix motif; other site 768494013434 S-ribosylhomocysteinase; Provisional; Region: PRK02260 768494013435 Haemolytic domain; Region: Haemolytic; pfam01809 768494013436 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 768494013437 active site clefts [active] 768494013438 zinc binding site [ion binding]; other site 768494013439 dimer interface [polypeptide binding]; other site 768494013440 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 768494013441 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768494013442 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768494013443 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 768494013444 S-layer homology domain; Region: SLH; pfam00395 768494013445 S-layer homology domain; Region: SLH; pfam00395 768494013446 S-layer homology domain; Region: SLH; pfam00395 768494013447 Excalibur calcium-binding domain; Region: Excalibur; smart00894 768494013448 Uncharacterized conserved protein [Function unknown]; Region: COG1434 768494013449 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768494013450 putative active site [active] 768494013451 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494013452 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768494013453 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494013454 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768494013455 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 768494013456 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 768494013457 Predicted membrane protein [Function unknown]; Region: COG3766 768494013458 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 768494013459 hypothetical protein; Provisional; Region: PRK12473 768494013460 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 768494013461 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 768494013462 G1 box; other site 768494013463 GTP/Mg2+ binding site [chemical binding]; other site 768494013464 Switch I region; other site 768494013465 G2 box; other site 768494013466 G3 box; other site 768494013467 Switch II region; other site 768494013468 G4 box; other site 768494013469 G5 box; other site 768494013470 Nucleoside recognition; Region: Gate; pfam07670 768494013471 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 768494013472 Nucleoside recognition; Region: Gate; pfam07670 768494013473 FeoA domain; Region: FeoA; pfam04023 768494013474 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 768494013475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494013476 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494013477 dimerization interface [polypeptide binding]; other site 768494013478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494013479 dimer interface [polypeptide binding]; other site 768494013480 phosphorylation site [posttranslational modification] 768494013481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494013482 ATP binding site [chemical binding]; other site 768494013483 Mg2+ binding site [ion binding]; other site 768494013484 G-X-G motif; other site 768494013485 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494013486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494013487 active site 768494013488 phosphorylation site [posttranslational modification] 768494013489 intermolecular recognition site; other site 768494013490 dimerization interface [polypeptide binding]; other site 768494013491 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494013492 DNA binding site [nucleotide binding] 768494013493 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 768494013494 active site 768494013495 catalytic site [active] 768494013496 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768494013497 active site 768494013498 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 768494013499 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 768494013500 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 768494013501 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 768494013502 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 768494013503 putative hydrophobic ligand binding site [chemical binding]; other site 768494013504 protein interface [polypeptide binding]; other site 768494013505 gate; other site 768494013506 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768494013507 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768494013508 active site 768494013509 catalytic tetrad [active] 768494013510 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 768494013511 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 768494013512 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768494013513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494013514 S-adenosylmethionine binding site [chemical binding]; other site 768494013515 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768494013516 FtsX-like permease family; Region: FtsX; pfam02687 768494013517 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768494013518 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768494013519 Walker A/P-loop; other site 768494013520 ATP binding site [chemical binding]; other site 768494013521 Q-loop/lid; other site 768494013522 ABC transporter signature motif; other site 768494013523 Walker B; other site 768494013524 D-loop; other site 768494013525 H-loop/switch region; other site 768494013526 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768494013527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768494013528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 768494013529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494013530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494013531 active site 768494013532 phosphorylation site [posttranslational modification] 768494013533 intermolecular recognition site; other site 768494013534 dimerization interface [polypeptide binding]; other site 768494013535 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494013536 DNA binding site [nucleotide binding] 768494013537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494013538 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 768494013539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494013540 ATP binding site [chemical binding]; other site 768494013541 Mg2+ binding site [ion binding]; other site 768494013542 G-X-G motif; other site 768494013543 FtsX-like permease family; Region: FtsX; pfam02687 768494013544 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768494013545 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768494013546 Walker A/P-loop; other site 768494013547 ATP binding site [chemical binding]; other site 768494013548 Q-loop/lid; other site 768494013549 ABC transporter signature motif; other site 768494013550 Walker B; other site 768494013551 D-loop; other site 768494013552 H-loop/switch region; other site 768494013553 GntP family permease; Region: GntP_permease; pfam02447 768494013554 fructuronate transporter; Provisional; Region: PRK10034; cl15264 768494013555 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768494013556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768494013557 DNA-binding site [nucleotide binding]; DNA binding site 768494013558 UTRA domain; Region: UTRA; pfam07702 768494013559 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768494013560 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768494013561 substrate binding site [chemical binding]; other site 768494013562 ATP binding site [chemical binding]; other site 768494013563 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 768494013564 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 768494013565 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768494013566 catalytic residue [active] 768494013567 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 768494013568 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 768494013569 active site 768494013570 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 768494013571 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 768494013572 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 768494013573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494013574 dimerization interface [polypeptide binding]; other site 768494013575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494013576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494013577 dimer interface [polypeptide binding]; other site 768494013578 phosphorylation site [posttranslational modification] 768494013579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494013580 ATP binding site [chemical binding]; other site 768494013581 Mg2+ binding site [ion binding]; other site 768494013582 G-X-G motif; other site 768494013583 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494013584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494013585 active site 768494013586 phosphorylation site [posttranslational modification] 768494013587 intermolecular recognition site; other site 768494013588 dimerization interface [polypeptide binding]; other site 768494013589 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494013590 DNA binding site [nucleotide binding] 768494013591 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 768494013592 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 768494013593 active site 768494013594 octamer interface [polypeptide binding]; other site 768494013595 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 768494013596 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 768494013597 acyl-activating enzyme (AAE) consensus motif; other site 768494013598 putative AMP binding site [chemical binding]; other site 768494013599 putative active site [active] 768494013600 putative CoA binding site [chemical binding]; other site 768494013601 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768494013602 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 768494013603 substrate binding site [chemical binding]; other site 768494013604 oxyanion hole (OAH) forming residues; other site 768494013605 trimer interface [polypeptide binding]; other site 768494013606 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 768494013607 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 768494013608 nucleophilic elbow; other site 768494013609 catalytic triad; other site 768494013610 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 768494013611 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 768494013612 dimer interface [polypeptide binding]; other site 768494013613 tetramer interface [polypeptide binding]; other site 768494013614 PYR/PP interface [polypeptide binding]; other site 768494013615 TPP binding site [chemical binding]; other site 768494013616 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 768494013617 TPP-binding site; other site 768494013618 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 768494013619 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768494013620 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 768494013621 UbiA prenyltransferase family; Region: UbiA; pfam01040 768494013622 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 768494013623 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768494013624 DNA-binding site [nucleotide binding]; DNA binding site 768494013625 RNA-binding motif; other site 768494013626 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 768494013627 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 768494013628 active site flap/lid [active] 768494013629 nucleophilic elbow; other site 768494013630 catalytic triad [active] 768494013631 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 768494013632 homodimer interface [polypeptide binding]; other site 768494013633 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 768494013634 active site pocket [active] 768494013635 glycogen synthase; Provisional; Region: glgA; PRK00654 768494013636 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 768494013637 ADP-binding pocket [chemical binding]; other site 768494013638 homodimer interface [polypeptide binding]; other site 768494013639 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 768494013640 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 768494013641 ligand binding site; other site 768494013642 oligomer interface; other site 768494013643 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 768494013644 dimer interface [polypeptide binding]; other site 768494013645 N-terminal domain interface [polypeptide binding]; other site 768494013646 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 768494013647 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 768494013648 ligand binding site; other site 768494013649 oligomer interface; other site 768494013650 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 768494013651 dimer interface [polypeptide binding]; other site 768494013652 N-terminal domain interface [polypeptide binding]; other site 768494013653 sulfate 1 binding site; other site 768494013654 glycogen branching enzyme; Provisional; Region: PRK12313 768494013655 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 768494013656 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 768494013657 active site 768494013658 catalytic site [active] 768494013659 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 768494013660 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 768494013661 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 768494013662 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768494013663 NAD binding site [chemical binding]; other site 768494013664 dimer interface [polypeptide binding]; other site 768494013665 substrate binding site [chemical binding]; other site 768494013666 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 768494013667 MgtC family; Region: MgtC; pfam02308 768494013668 Ion channel; Region: Ion_trans_2; pfam07885 768494013669 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 768494013670 TrkA-N domain; Region: TrkA_N; pfam02254 768494013671 YugN-like family; Region: YugN; pfam08868 768494013672 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 768494013673 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 768494013674 active site 768494013675 dimer interface [polypeptide binding]; other site 768494013676 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 768494013677 dimer interface [polypeptide binding]; other site 768494013678 active site 768494013679 Domain of unknown function (DUF378); Region: DUF378; pfam04070 768494013680 general stress protein 13; Validated; Region: PRK08059 768494013681 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768494013682 RNA binding site [nucleotide binding]; other site 768494013683 hypothetical protein; Validated; Region: PRK07682 768494013684 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494013685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494013686 homodimer interface [polypeptide binding]; other site 768494013687 catalytic residue [active] 768494013688 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768494013689 AsnC family; Region: AsnC_trans_reg; pfam01037 768494013690 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 768494013691 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 768494013692 dimerization interface [polypeptide binding]; other site 768494013693 ligand binding site [chemical binding]; other site 768494013694 NADP binding site [chemical binding]; other site 768494013695 catalytic site [active] 768494013696 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 768494013697 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768494013698 nucleophilic elbow; other site 768494013699 catalytic triad; other site 768494013700 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 768494013701 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 768494013702 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768494013703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494013704 homodimer interface [polypeptide binding]; other site 768494013705 catalytic residue [active] 768494013706 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 768494013707 E-class dimer interface [polypeptide binding]; other site 768494013708 P-class dimer interface [polypeptide binding]; other site 768494013709 active site 768494013710 Cu2+ binding site [ion binding]; other site 768494013711 Zn2+ binding site [ion binding]; other site 768494013712 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 768494013713 Kinase associated protein B; Region: KapB; pfam08810 768494013714 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 768494013715 active site 768494013716 catalytic site [active] 768494013717 substrate binding site [chemical binding]; other site 768494013718 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 768494013719 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 768494013720 transmembrane helices; other site 768494013721 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 768494013722 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 768494013723 active site 768494013724 glycyl-tRNA synthetase; Provisional; Region: PRK04173 768494013725 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768494013726 motif 1; other site 768494013727 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 768494013728 active site 768494013729 motif 2; other site 768494013730 motif 3; other site 768494013731 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 768494013732 anticodon binding site; other site 768494013733 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768494013734 CoenzymeA binding site [chemical binding]; other site 768494013735 subunit interaction site [polypeptide binding]; other site 768494013736 PHB binding site; other site 768494013737 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 768494013738 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 768494013739 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768494013740 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 768494013741 active site 768494013742 tetramer interface; other site 768494013743 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 768494013744 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 768494013745 active site 768494013746 substrate binding site [chemical binding]; other site 768494013747 metal binding site [ion binding]; metal-binding site 768494013748 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 768494013749 Uncharacterized conserved protein [Function unknown]; Region: COG1624 768494013750 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 768494013751 multifunctional aminopeptidase A; Provisional; Region: PRK00913 768494013752 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 768494013753 interface (dimer of trimers) [polypeptide binding]; other site 768494013754 Substrate-binding/catalytic site; other site 768494013755 Zn-binding sites [ion binding]; other site 768494013756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 768494013757 Putative membrane protein; Region: YuiB; pfam14068 768494013758 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 768494013759 nudix motif; other site 768494013760 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768494013761 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494013762 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 768494013763 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768494013764 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494013765 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 768494013766 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 768494013767 Domain of unknown function DUF11; Region: DUF11; pfam01345 768494013768 Domain of unknown function DUF11; Region: DUF11; pfam01345 768494013769 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 768494013770 Domain of unknown function DUF11; Region: DUF11; pfam01345 768494013771 Domain of unknown function DUF11; Region: DUF11; cl17728 768494013772 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 768494013773 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 768494013774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 768494013775 H+ Antiporter protein; Region: 2A0121; TIGR00900 768494013776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494013777 putative substrate translocation pore; other site 768494013778 Helix-turn-helix domain; Region: HTH_36; pfam13730 768494013779 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768494013780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 768494013781 putative DNA binding site [nucleotide binding]; other site 768494013782 dimerization interface [polypeptide binding]; other site 768494013783 Protein of unknown function (DUF523); Region: DUF523; pfam04463 768494013784 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 768494013785 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 768494013786 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494013787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494013788 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 768494013789 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 768494013790 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768494013791 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768494013792 hypothetical protein; Provisional; Region: PRK13669 768494013793 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768494013794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494013795 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 768494013796 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768494013797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494013798 Walker A/P-loop; other site 768494013799 ATP binding site [chemical binding]; other site 768494013800 Q-loop/lid; other site 768494013801 ABC transporter signature motif; other site 768494013802 Walker B; other site 768494013803 D-loop; other site 768494013804 H-loop/switch region; other site 768494013805 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 768494013806 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 768494013807 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 768494013808 PhnA protein; Region: PhnA; pfam03831 768494013809 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 768494013810 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 768494013811 PQQ-like domain; Region: PQQ_2; pfam13360 768494013812 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 768494013813 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 768494013814 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 768494013815 CAAX protease self-immunity; Region: Abi; pfam02517 768494013816 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 768494013817 active site 768494013818 NTP binding site [chemical binding]; other site 768494013819 metal binding triad [ion binding]; metal-binding site 768494013820 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 768494013821 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 768494013822 NifU-like domain; Region: NifU; pfam01106 768494013823 spore coat protein YutH; Region: spore_yutH; TIGR02905 768494013824 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 768494013825 tetramer interfaces [polypeptide binding]; other site 768494013826 binuclear metal-binding site [ion binding]; other site 768494013827 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 768494013828 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 768494013829 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768494013830 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 768494013831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494013832 active site 768494013833 motif I; other site 768494013834 motif II; other site 768494013835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494013836 Predicted transcriptional regulator [Transcription]; Region: COG2345 768494013837 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494013838 putative Zn2+ binding site [ion binding]; other site 768494013839 putative DNA binding site [nucleotide binding]; other site 768494013840 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 768494013841 Uncharacterized conserved protein [Function unknown]; Region: COG2445 768494013842 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 768494013843 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 768494013844 putative active site [active] 768494013845 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 768494013846 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 768494013847 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 768494013848 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 768494013849 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768494013850 DNA binding residues [nucleotide binding] 768494013851 dimer interface [polypeptide binding]; other site 768494013852 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768494013853 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 768494013854 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768494013855 catalytic core [active] 768494013856 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 768494013857 putative deacylase active site [active] 768494013858 lipoyl synthase; Provisional; Region: PRK05481 768494013859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494013860 FeS/SAM binding site; other site 768494013861 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 768494013862 Peptidase family M23; Region: Peptidase_M23; pfam01551 768494013863 sporulation protein YunB; Region: spo_yunB; TIGR02832 768494013864 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 768494013865 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 768494013866 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 768494013867 active site 768494013868 metal binding site [ion binding]; metal-binding site 768494013869 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 768494013870 Predicted transcriptional regulators [Transcription]; Region: COG1695 768494013871 Transcriptional regulator PadR-like family; Region: PadR; cl17335 768494013872 VanZ like family; Region: VanZ; pfam04892 768494013873 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 768494013874 FeS assembly protein SufB; Region: sufB; TIGR01980 768494013875 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 768494013876 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 768494013877 trimerization site [polypeptide binding]; other site 768494013878 active site 768494013879 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768494013880 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768494013881 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768494013882 catalytic residue [active] 768494013883 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 768494013884 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 768494013885 FeS assembly protein SufD; Region: sufD; TIGR01981 768494013886 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 768494013887 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 768494013888 Walker A/P-loop; other site 768494013889 ATP binding site [chemical binding]; other site 768494013890 Q-loop/lid; other site 768494013891 ABC transporter signature motif; other site 768494013892 Walker B; other site 768494013893 D-loop; other site 768494013894 H-loop/switch region; other site 768494013895 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768494013896 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768494013897 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768494013898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768494013899 ABC-ATPase subunit interface; other site 768494013900 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 768494013901 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768494013902 Walker A/P-loop; other site 768494013903 ATP binding site [chemical binding]; other site 768494013904 Q-loop/lid; other site 768494013905 ABC transporter signature motif; other site 768494013906 Walker B; other site 768494013907 D-loop; other site 768494013908 H-loop/switch region; other site 768494013909 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 768494013910 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768494013911 catalytic residues [active] 768494013912 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 768494013913 putative active site [active] 768494013914 putative metal binding site [ion binding]; other site 768494013915 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 768494013916 lipoyl attachment site [posttranslational modification]; other site 768494013917 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 768494013918 ArsC family; Region: ArsC; pfam03960 768494013919 putative ArsC-like catalytic residues; other site 768494013920 putative TRX-like catalytic residues [active] 768494013921 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 768494013922 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 768494013923 active site 768494013924 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 768494013925 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 768494013926 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 768494013927 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 768494013928 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768494013929 NAD binding site [chemical binding]; other site 768494013930 dimer interface [polypeptide binding]; other site 768494013931 substrate binding site [chemical binding]; other site 768494013932 Coat F domain; Region: Coat_F; pfam07875 768494013933 CAAX protease self-immunity; Region: Abi; pfam02517 768494013934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494013935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494013936 WHG domain; Region: WHG; pfam13305 768494013937 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768494013938 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768494013939 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768494013940 active site 768494013941 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 768494013942 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768494013943 dimer interface [polypeptide binding]; other site 768494013944 active site 768494013945 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 768494013946 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768494013947 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768494013948 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768494013949 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768494013950 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 768494013951 substrate binding site [chemical binding]; other site 768494013952 oxyanion hole (OAH) forming residues; other site 768494013953 YuzL-like protein; Region: YuzL; pfam14115 768494013954 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768494013955 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768494013956 Proline dehydrogenase; Region: Pro_dh; cl03282 768494013957 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 768494013958 Domain of unknown function DUF77; Region: DUF77; pfam01910 768494013959 Cache domain; Region: Cache_1; pfam02743 768494013960 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494013961 dimerization interface [polypeptide binding]; other site 768494013962 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494013963 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768494013964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494013965 dimer interface [polypeptide binding]; other site 768494013966 putative CheW interface [polypeptide binding]; other site 768494013967 Predicted transcriptional regulators [Transcription]; Region: COG1378 768494013968 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 768494013969 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 768494013970 C-terminal domain interface [polypeptide binding]; other site 768494013971 sugar binding site [chemical binding]; other site 768494013972 TQXA domain; Region: TQXA_dom; TIGR03934 768494013973 Cna protein B-type domain; Region: Cna_B; pfam05738 768494013974 Cna protein B-type domain; Region: Cna_B; pfam05738 768494013975 Cna protein B-type domain; Region: Cna_B; pfam05738 768494013976 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768494013977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494013978 putative substrate translocation pore; other site 768494013979 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 768494013980 Spore germination protein; Region: Spore_permease; cl17796 768494013981 MAEBL; Provisional; Region: PTZ00121 768494013982 OxaA-like protein precursor; Validated; Region: PRK01622 768494013983 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768494013984 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 768494013985 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 768494013986 hypothetical protein; Provisional; Region: PRK06758 768494013987 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 768494013988 active site 768494013989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494013990 non-specific DNA binding site [nucleotide binding]; other site 768494013991 salt bridge; other site 768494013992 sequence-specific DNA binding site [nucleotide binding]; other site 768494013993 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768494013994 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768494013995 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 768494013996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 768494013997 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768494013998 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494013999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494014000 active site 768494014001 phosphorylation site [posttranslational modification] 768494014002 intermolecular recognition site; other site 768494014003 dimerization interface [polypeptide binding]; other site 768494014004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494014005 DNA binding site [nucleotide binding] 768494014006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494014007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494014008 dimer interface [polypeptide binding]; other site 768494014009 phosphorylation site [posttranslational modification] 768494014010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494014011 ATP binding site [chemical binding]; other site 768494014012 Mg2+ binding site [ion binding]; other site 768494014013 G-X-G motif; other site 768494014014 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768494014015 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 768494014016 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 768494014017 active site 768494014018 HIGH motif; other site 768494014019 KMSKS motif; other site 768494014020 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 768494014021 tRNA binding surface [nucleotide binding]; other site 768494014022 anticodon binding site; other site 768494014023 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768494014024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494014025 S-adenosylmethionine binding site [chemical binding]; other site 768494014026 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494014027 dimerization interface [polypeptide binding]; other site 768494014028 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494014029 dimer interface [polypeptide binding]; other site 768494014030 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768494014031 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494014032 dimer interface [polypeptide binding]; other site 768494014033 putative CheW interface [polypeptide binding]; other site 768494014034 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 768494014035 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 768494014036 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 768494014037 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 768494014038 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 768494014039 active site 768494014040 Zn binding site [ion binding]; other site 768494014041 Pirin-related protein [General function prediction only]; Region: COG1741 768494014042 Pirin; Region: Pirin; pfam02678 768494014043 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768494014044 MarR family; Region: MarR_2; pfam12802 768494014045 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 768494014046 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 768494014047 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768494014048 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 768494014049 TrkA-C domain; Region: TrkA_C; pfam02080 768494014050 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768494014051 amino acid carrier protein; Region: agcS; TIGR00835 768494014052 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 768494014053 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 768494014054 dimerization interface [polypeptide binding]; other site 768494014055 DPS ferroxidase diiron center [ion binding]; other site 768494014056 ion pore; other site 768494014057 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 768494014058 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 768494014059 metal binding site [ion binding]; metal-binding site 768494014060 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 768494014061 Ferritin-like domain; Region: Ferritin; pfam00210 768494014062 ferroxidase diiron center [ion binding]; other site 768494014063 Predicted membrane protein [Function unknown]; Region: COG2311 768494014064 Protein of unknown function (DUF418); Region: DUF418; pfam04235 768494014065 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768494014066 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768494014067 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768494014068 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768494014069 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768494014070 Nucleoside recognition; Region: Gate; pfam07670 768494014071 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768494014072 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768494014073 amino acid carrier protein; Region: agcS; TIGR00835 768494014074 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768494014075 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 768494014076 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 768494014077 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768494014078 NAD binding site [chemical binding]; other site 768494014079 substrate binding site [chemical binding]; other site 768494014080 putative active site [active] 768494014081 Viral enhancin protein; Region: Enhancin; pfam03272 768494014082 potential frameshift: common BLAST hit: gi|52140468|ref|YP_086361.1| wall-associated protein 768494014083 Peptidase M60-like family; Region: M60-like; pfam13402 768494014084 TQXA domain; Region: TQXA_dom; TIGR03934 768494014085 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768494014086 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768494014087 active site 768494014088 catalytic tetrad [active] 768494014089 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768494014090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494014091 putative substrate translocation pore; other site 768494014092 Predicted transcriptional regulators [Transcription]; Region: COG1733 768494014093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768494014094 dimerization interface [polypeptide binding]; other site 768494014095 putative DNA binding site [nucleotide binding]; other site 768494014096 putative Zn2+ binding site [ion binding]; other site 768494014097 Uncharacterized conserved protein [Function unknown]; Region: COG2427 768494014098 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768494014099 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494014100 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 768494014101 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 768494014102 active site 768494014103 HIGH motif; other site 768494014104 dimer interface [polypeptide binding]; other site 768494014105 KMSKS motif; other site 768494014106 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768494014107 RNA binding surface [nucleotide binding]; other site 768494014108 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 768494014109 FAD binding domain; Region: FAD_binding_4; pfam01565 768494014110 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 768494014111 SET domain; Region: SET; pfam00856 768494014112 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 768494014113 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768494014114 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494014115 dimer interface [polypeptide binding]; other site 768494014116 putative CheW interface [polypeptide binding]; other site 768494014117 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768494014118 putative phosphate binding site [ion binding]; other site 768494014119 camphor resistance protein CrcB; Provisional; Region: PRK14219 768494014120 camphor resistance protein CrcB; Provisional; Region: PRK14205 768494014121 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 768494014122 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 768494014123 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768494014124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768494014125 Coenzyme A binding pocket [chemical binding]; other site 768494014126 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 768494014127 Nuclease-related domain; Region: NERD; pfam08378 768494014128 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768494014129 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 768494014130 Walker A/P-loop; other site 768494014131 ATP binding site [chemical binding]; other site 768494014132 Q-loop/lid; other site 768494014133 ABC transporter signature motif; other site 768494014134 Walker B; other site 768494014135 D-loop; other site 768494014136 H-loop/switch region; other site 768494014137 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494014138 ABC-ATPase subunit interface; other site 768494014139 dimer interface [polypeptide binding]; other site 768494014140 putative PBP binding regions; other site 768494014141 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768494014142 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494014143 ABC-ATPase subunit interface; other site 768494014144 dimer interface [polypeptide binding]; other site 768494014145 putative PBP binding regions; other site 768494014146 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 768494014147 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 768494014148 putative ligand binding residues [chemical binding]; other site 768494014149 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494014150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494014151 active site 768494014152 phosphorylation site [posttranslational modification] 768494014153 intermolecular recognition site; other site 768494014154 dimerization interface [polypeptide binding]; other site 768494014155 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494014156 DNA binding site [nucleotide binding] 768494014157 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 768494014158 SmpB-tmRNA interface; other site 768494014159 ribonuclease R; Region: RNase_R; TIGR02063 768494014160 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 768494014161 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768494014162 RNB domain; Region: RNB; pfam00773 768494014163 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 768494014164 RNA binding site [nucleotide binding]; other site 768494014165 Esterase/lipase [General function prediction only]; Region: COG1647 768494014166 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 768494014167 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 768494014168 holin-like protein; Validated; Region: PRK01658 768494014169 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 768494014170 active site 768494014171 NUMOD4 motif; Region: NUMOD4; pfam07463 768494014172 HNH endonuclease; Region: HNH_3; pfam13392 768494014173 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 768494014174 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 768494014175 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 768494014176 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 768494014177 active site 768494014178 Phage-related protein [Function unknown]; Region: COG4695; cl01923 768494014179 Phage portal protein; Region: Phage_portal; pfam04860 768494014180 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 768494014181 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 768494014182 Phage capsid family; Region: Phage_capsid; pfam05065 768494014183 Phage capsid family; Region: Phage_capsid; pfam05065 768494014184 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 768494014185 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768494014186 active site 768494014187 DNA binding site [nucleotide binding] 768494014188 Int/Topo IB signature motif; other site 768494014189 enolase; Provisional; Region: eno; PRK00077 768494014190 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 768494014191 dimer interface [polypeptide binding]; other site 768494014192 metal binding site [ion binding]; metal-binding site 768494014193 substrate binding pocket [chemical binding]; other site 768494014194 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 768494014195 phosphoglyceromutase; Provisional; Region: PRK05434 768494014196 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 768494014197 triosephosphate isomerase; Provisional; Region: PRK14565 768494014198 substrate binding site [chemical binding]; other site 768494014199 dimer interface [polypeptide binding]; other site 768494014200 catalytic triad [active] 768494014201 Phosphoglycerate kinase; Region: PGK; pfam00162 768494014202 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 768494014203 substrate binding site [chemical binding]; other site 768494014204 hinge regions; other site 768494014205 ADP binding site [chemical binding]; other site 768494014206 catalytic site [active] 768494014207 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 768494014208 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768494014209 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768494014210 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 768494014211 Predicted transcriptional regulator [Transcription]; Region: COG3388 768494014212 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 768494014213 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 768494014214 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 768494014215 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 768494014216 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 768494014217 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 768494014218 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 768494014219 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 768494014220 stage V sporulation protein AD; Provisional; Region: PRK12404 768494014221 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 768494014222 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 768494014223 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 768494014224 Predicted membrane protein [Function unknown]; Region: COG2323 768494014225 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 768494014226 Clp protease; Region: CLP_protease; pfam00574 768494014227 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768494014228 oligomer interface [polypeptide binding]; other site 768494014229 active site residues [active] 768494014230 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768494014231 dimerization domain swap beta strand [polypeptide binding]; other site 768494014232 regulatory protein interface [polypeptide binding]; other site 768494014233 active site 768494014234 regulatory phosphorylation site [posttranslational modification]; other site 768494014235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 768494014236 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 768494014237 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 768494014238 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 768494014239 phosphate binding site [ion binding]; other site 768494014240 putative substrate binding pocket [chemical binding]; other site 768494014241 dimer interface [polypeptide binding]; other site 768494014242 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 768494014243 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 768494014244 putative active site [active] 768494014245 nucleotide binding site [chemical binding]; other site 768494014246 nudix motif; other site 768494014247 putative metal binding site [ion binding]; other site 768494014248 Domain of unknown function (DUF368); Region: DUF368; pfam04018 768494014249 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 768494014250 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768494014251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768494014252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494014253 binding surface 768494014254 TPR motif; other site 768494014255 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768494014256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768494014257 binding surface 768494014258 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768494014259 TPR motif; other site 768494014260 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 768494014261 trimer interface [polypeptide binding]; other site 768494014262 active site 768494014263 substrate binding site [chemical binding]; other site 768494014264 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 768494014265 CoA binding site [chemical binding]; other site 768494014266 pyrophosphatase PpaX; Provisional; Region: PRK13288 768494014267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494014268 active site 768494014269 motif I; other site 768494014270 motif II; other site 768494014271 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 768494014272 HPr kinase/phosphorylase; Provisional; Region: PRK05428 768494014273 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 768494014274 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 768494014275 Hpr binding site; other site 768494014276 active site 768494014277 homohexamer subunit interaction site [polypeptide binding]; other site 768494014278 Predicted membrane protein [Function unknown]; Region: COG1950 768494014279 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 768494014280 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 768494014281 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768494014282 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768494014283 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 768494014284 excinuclease ABC subunit B; Provisional; Region: PRK05298 768494014285 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768494014286 ATP binding site [chemical binding]; other site 768494014287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494014288 nucleotide binding region [chemical binding]; other site 768494014289 ATP-binding site [chemical binding]; other site 768494014290 Ultra-violet resistance protein B; Region: UvrB; pfam12344 768494014291 Probable transposase; Region: OrfB_IS605; pfam01385 768494014292 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 768494014293 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 768494014294 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 768494014295 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 768494014296 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768494014297 DNA binding residues [nucleotide binding] 768494014298 dimer interface [polypeptide binding]; other site 768494014299 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768494014300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768494014301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494014302 non-specific DNA binding site [nucleotide binding]; other site 768494014303 salt bridge; other site 768494014304 sequence-specific DNA binding site [nucleotide binding]; other site 768494014305 Predicted membrane protein [Function unknown]; Region: COG2855 768494014306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768494014307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494014308 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 768494014309 putative dimerization interface [polypeptide binding]; other site 768494014310 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 768494014311 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768494014312 DNA binding residues [nucleotide binding] 768494014313 putative dimer interface [polypeptide binding]; other site 768494014314 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 768494014315 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768494014316 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 768494014317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494014318 ABC transporter; Region: ABC_tran_2; pfam12848 768494014319 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494014320 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 768494014321 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 768494014322 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768494014323 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768494014324 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 768494014325 Walker A/P-loop; other site 768494014326 ATP binding site [chemical binding]; other site 768494014327 Q-loop/lid; other site 768494014328 ABC transporter signature motif; other site 768494014329 Walker B; other site 768494014330 D-loop; other site 768494014331 H-loop/switch region; other site 768494014332 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768494014333 protein binding site [polypeptide binding]; other site 768494014334 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 768494014335 C-terminal peptidase (prc); Region: prc; TIGR00225 768494014336 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 768494014337 protein binding site [polypeptide binding]; other site 768494014338 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 768494014339 Catalytic dyad [active] 768494014340 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 768494014341 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 768494014342 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 768494014343 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 768494014344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494014345 Walker A/P-loop; other site 768494014346 ATP binding site [chemical binding]; other site 768494014347 Q-loop/lid; other site 768494014348 ABC transporter signature motif; other site 768494014349 Walker B; other site 768494014350 D-loop; other site 768494014351 H-loop/switch region; other site 768494014352 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768494014353 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768494014354 peptide chain release factor 2; Provisional; Region: PRK06746 768494014355 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768494014356 RF-1 domain; Region: RF-1; pfam00472 768494014357 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 768494014358 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 768494014359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 768494014360 nucleotide binding region [chemical binding]; other site 768494014361 ATP-binding site [chemical binding]; other site 768494014362 SEC-C motif; Region: SEC-C; pfam02810 768494014363 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 768494014364 30S subunit binding site; other site 768494014365 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768494014366 DNA-binding site [nucleotide binding]; DNA binding site 768494014367 RNA-binding motif; other site 768494014368 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 768494014369 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768494014370 active site 768494014371 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 768494014372 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768494014373 ATP binding site [chemical binding]; other site 768494014374 putative Mg++ binding site [ion binding]; other site 768494014375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494014376 nucleotide binding region [chemical binding]; other site 768494014377 ATP-binding site [chemical binding]; other site 768494014378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 768494014379 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768494014380 NlpC/P60 family; Region: NLPC_P60; pfam00877 768494014381 Predicted transcriptional regulators [Transcription]; Region: COG1733 768494014382 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 768494014383 EDD domain protein, DegV family; Region: DegV; TIGR00762 768494014384 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 768494014385 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 768494014386 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 768494014387 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 768494014388 Transcriptional regulator [Transcription]; Region: LytR; COG1316 768494014389 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 768494014390 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 768494014391 active site 768494014392 homodimer interface [polypeptide binding]; other site 768494014393 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 768494014394 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768494014395 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768494014396 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 768494014397 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 768494014398 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 768494014399 Mg++ binding site [ion binding]; other site 768494014400 putative catalytic motif [active] 768494014401 substrate binding site [chemical binding]; other site 768494014402 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 768494014403 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 768494014404 NodB motif; other site 768494014405 active site 768494014406 catalytic site [active] 768494014407 Zn binding site [ion binding]; other site 768494014408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768494014409 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 768494014410 Walker A motif; other site 768494014411 ATP binding site [chemical binding]; other site 768494014412 Walker B motif; other site 768494014413 arginine finger; other site 768494014414 Transcriptional antiterminator [Transcription]; Region: COG3933 768494014415 PRD domain; Region: PRD; pfam00874 768494014416 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 768494014417 active pocket/dimerization site; other site 768494014418 active site 768494014419 phosphorylation site [posttranslational modification] 768494014420 PRD domain; Region: PRD; pfam00874 768494014421 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 768494014422 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 768494014423 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 768494014424 Chromate transporter; Region: Chromate_transp; pfam02417 768494014425 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 768494014426 putative active site [active] 768494014427 YdjC motif; other site 768494014428 Mg binding site [ion binding]; other site 768494014429 putative homodimer interface [polypeptide binding]; other site 768494014430 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 768494014431 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 768494014432 NAD binding site [chemical binding]; other site 768494014433 sugar binding site [chemical binding]; other site 768494014434 divalent metal binding site [ion binding]; other site 768494014435 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768494014436 dimer interface [polypeptide binding]; other site 768494014437 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768494014438 active site 768494014439 methionine cluster; other site 768494014440 phosphorylation site [posttranslational modification] 768494014441 metal binding site [ion binding]; metal-binding site 768494014442 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768494014443 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 768494014444 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768494014445 active site 768494014446 P-loop; other site 768494014447 phosphorylation site [posttranslational modification] 768494014448 spermidine synthase; Provisional; Region: PRK03612 768494014449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494014450 S-adenosylmethionine binding site [chemical binding]; other site 768494014451 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 768494014452 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 768494014453 methionine cluster; other site 768494014454 active site 768494014455 phosphorylation site [posttranslational modification] 768494014456 metal binding site [ion binding]; metal-binding site 768494014457 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 768494014458 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 768494014459 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 768494014460 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 768494014461 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768494014462 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768494014463 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 768494014464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768494014465 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 768494014466 Predicted membrane protein [Function unknown]; Region: COG1511 768494014467 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 768494014468 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 768494014469 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 768494014470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768494014471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768494014472 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 768494014473 putative dimerization interface [polypeptide binding]; other site 768494014474 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 768494014475 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 768494014476 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 768494014477 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 768494014478 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 768494014479 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 768494014480 transmembrane helices; other site 768494014481 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 768494014482 ThiC-associated domain; Region: ThiC-associated; pfam13667 768494014483 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 768494014484 L-lactate permease; Region: Lactate_perm; cl00701 768494014485 glycolate transporter; Provisional; Region: PRK09695 768494014486 Tic20-like protein; Region: Tic20; pfam09685 768494014487 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 768494014488 Uncharacterized conserved protein [Function unknown]; Region: COG3339 768494014489 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 768494014490 Sulfatase; Region: Sulfatase; pfam00884 768494014491 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768494014492 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 768494014493 homodimer interface [polypeptide binding]; other site 768494014494 substrate-cofactor binding pocket; other site 768494014495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494014496 catalytic residue [active] 768494014497 Bacterial SH3 domain; Region: SH3_3; cl17532 768494014498 Bacterial SH3 domain; Region: SH3_3; cl17532 768494014499 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494014500 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494014501 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768494014502 NlpC/P60 family; Region: NLPC_P60; pfam00877 768494014503 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768494014504 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768494014505 Nucleoside recognition; Region: Gate; pfam07670 768494014506 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768494014507 Uncharacterized conserved protein (DUF2215); Region: DUF2215; pfam10225 768494014508 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 768494014509 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 768494014510 DXD motif; other site 768494014511 BCCT family transporter; Region: BCCT; pfam02028 768494014512 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494014513 Bacterial SH3 domain; Region: SH3_3; pfam08239 768494014514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 768494014515 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 768494014516 Predicted membrane protein [Function unknown]; Region: COG4640 768494014517 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 768494014518 Double zinc ribbon; Region: DZR; pfam12773 768494014519 Double zinc ribbon; Region: DZR; pfam12773 768494014520 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 768494014521 SNF2 Helicase protein; Region: DUF3670; pfam12419 768494014522 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 768494014523 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768494014524 ATP binding site [chemical binding]; other site 768494014525 putative Mg++ binding site [ion binding]; other site 768494014526 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 768494014527 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494014528 nucleotide binding region [chemical binding]; other site 768494014529 ATP-binding site [chemical binding]; other site 768494014530 Predicted integral membrane protein [Function unknown]; Region: COG5652 768494014531 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 768494014532 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 768494014533 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 768494014534 ComK protein; Region: ComK; pfam06338 768494014535 RNA polymerase factor sigma-70; Validated; Region: PRK06759 768494014536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494014537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494014538 DNA binding residues [nucleotide binding] 768494014539 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 768494014540 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768494014541 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768494014542 FtsX-like permease family; Region: FtsX; pfam02687 768494014543 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768494014544 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768494014545 Walker A/P-loop; other site 768494014546 ATP binding site [chemical binding]; other site 768494014547 Q-loop/lid; other site 768494014548 ABC transporter signature motif; other site 768494014549 Walker B; other site 768494014550 D-loop; other site 768494014551 H-loop/switch region; other site 768494014552 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768494014553 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768494014554 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 768494014555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494014556 putative substrate translocation pore; other site 768494014557 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768494014558 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 768494014559 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 768494014560 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 768494014561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768494014562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494014563 dimerization interface [polypeptide binding]; other site 768494014564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494014565 dimer interface [polypeptide binding]; other site 768494014566 phosphorylation site [posttranslational modification] 768494014567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494014568 ATP binding site [chemical binding]; other site 768494014569 Mg2+ binding site [ion binding]; other site 768494014570 G-X-G motif; other site 768494014571 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494014572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494014573 active site 768494014574 phosphorylation site [posttranslational modification] 768494014575 intermolecular recognition site; other site 768494014576 dimerization interface [polypeptide binding]; other site 768494014577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494014578 DNA binding site [nucleotide binding] 768494014579 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 768494014580 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768494014581 NAD binding site [chemical binding]; other site 768494014582 homodimer interface [polypeptide binding]; other site 768494014583 active site 768494014584 substrate binding site [chemical binding]; other site 768494014585 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 768494014586 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768494014587 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 768494014588 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 768494014589 active site 768494014590 homodimer interface [polypeptide binding]; other site 768494014591 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 768494014592 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 768494014593 Walker A/P-loop; other site 768494014594 ATP binding site [chemical binding]; other site 768494014595 Q-loop/lid; other site 768494014596 ABC transporter signature motif; other site 768494014597 Walker B; other site 768494014598 D-loop; other site 768494014599 H-loop/switch region; other site 768494014600 Bacterial SH3 domain homologues; Region: SH3b; smart00287 768494014601 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 768494014602 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768494014603 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 768494014604 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768494014605 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 768494014606 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 768494014607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768494014608 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768494014609 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768494014610 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768494014611 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 768494014612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 768494014613 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 768494014614 potential frameshift: common BLAST hit: gi|227818038|ref|YP_002818047.1| glycoside hydrolase family protein 768494014615 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768494014616 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768494014617 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768494014618 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768494014619 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 768494014620 rod shape-determining protein Mbl; Provisional; Region: PRK13928 768494014621 MreB and similar proteins; Region: MreB_like; cd10225 768494014622 nucleotide binding site [chemical binding]; other site 768494014623 Mg binding site [ion binding]; other site 768494014624 putative protofilament interaction site [polypeptide binding]; other site 768494014625 RodZ interaction site [polypeptide binding]; other site 768494014626 Stage III sporulation protein D; Region: SpoIIID; cl17560 768494014627 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 768494014628 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 768494014629 Peptidase family M23; Region: Peptidase_M23; pfam01551 768494014630 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 768494014631 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 768494014632 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494014633 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494014634 Walker A/P-loop; other site 768494014635 ATP binding site [chemical binding]; other site 768494014636 Q-loop/lid; other site 768494014637 ABC transporter signature motif; other site 768494014638 Walker B; other site 768494014639 D-loop; other site 768494014640 H-loop/switch region; other site 768494014641 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 768494014642 LytTr DNA-binding domain; Region: LytTR; pfam04397 768494014643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768494014644 Walker A/P-loop; other site 768494014645 ATP binding site [chemical binding]; other site 768494014646 ABC transporter; Region: ABC_tran; pfam00005 768494014647 Q-loop/lid; other site 768494014648 ABC transporter signature motif; other site 768494014649 Walker B; other site 768494014650 D-loop; other site 768494014651 Stage II sporulation protein; Region: SpoIID; pfam08486 768494014652 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 768494014653 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 768494014654 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 768494014655 hinge; other site 768494014656 active site 768494014657 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 768494014658 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 768494014659 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 768494014660 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768494014661 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 768494014662 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768494014663 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 768494014664 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 768494014665 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768494014666 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 768494014667 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 768494014668 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 768494014669 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 768494014670 4Fe-4S binding domain; Region: Fer4; cl02805 768494014671 4Fe-4S binding domain; Region: Fer4; pfam00037 768494014672 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 768494014673 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 768494014674 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 768494014675 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 768494014676 NADH dehydrogenase subunit C; Validated; Region: PRK07735 768494014677 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 768494014678 NADH dehydrogenase subunit B; Validated; Region: PRK06411 768494014679 NADH dehydrogenase subunit A; Validated; Region: PRK07756 768494014680 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494014681 PAS domain; Region: PAS_9; pfam13426 768494014682 putative active site [active] 768494014683 heme pocket [chemical binding]; other site 768494014684 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768494014685 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768494014686 metal binding site [ion binding]; metal-binding site 768494014687 active site 768494014688 I-site; other site 768494014689 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768494014690 Protein of unknown function (DUF975); Region: DUF975; cl10504 768494014691 Protein of unknown function (DUF975); Region: DUF975; cl10504 768494014692 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 768494014693 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 768494014694 gamma subunit interface [polypeptide binding]; other site 768494014695 epsilon subunit interface [polypeptide binding]; other site 768494014696 LBP interface [polypeptide binding]; other site 768494014697 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 768494014698 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768494014699 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 768494014700 alpha subunit interaction interface [polypeptide binding]; other site 768494014701 Walker A motif; other site 768494014702 ATP binding site [chemical binding]; other site 768494014703 Walker B motif; other site 768494014704 inhibitor binding site; inhibition site 768494014705 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768494014706 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 768494014707 core domain interface [polypeptide binding]; other site 768494014708 delta subunit interface [polypeptide binding]; other site 768494014709 epsilon subunit interface [polypeptide binding]; other site 768494014710 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 768494014711 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768494014712 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 768494014713 beta subunit interaction interface [polypeptide binding]; other site 768494014714 Walker A motif; other site 768494014715 ATP binding site [chemical binding]; other site 768494014716 Walker B motif; other site 768494014717 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768494014718 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 768494014719 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 768494014720 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 768494014721 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 768494014722 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 768494014723 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 768494014724 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 768494014725 ATP synthase I chain; Region: ATP_synt_I; pfam03899 768494014726 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 768494014727 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768494014728 active site 768494014729 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 768494014730 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 768494014731 dimer interface [polypeptide binding]; other site 768494014732 active site 768494014733 glycine-pyridoxal phosphate binding site [chemical binding]; other site 768494014734 folate binding site [chemical binding]; other site 768494014735 hypothetical protein; Provisional; Region: PRK13690 768494014736 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 768494014737 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 768494014738 Low molecular weight phosphatase family; Region: LMWPc; cl00105 768494014739 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 768494014740 HPr interaction site; other site 768494014741 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768494014742 active site 768494014743 phosphorylation site [posttranslational modification] 768494014744 Predicted membrane protein [Function unknown]; Region: COG2259 768494014745 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 768494014746 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 768494014747 Predicted membrane protein [Function unknown]; Region: COG1971 768494014748 Domain of unknown function DUF; Region: DUF204; pfam02659 768494014749 Domain of unknown function DUF; Region: DUF204; pfam02659 768494014750 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 768494014751 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 768494014752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768494014753 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 768494014754 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 768494014755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494014756 S-adenosylmethionine binding site [chemical binding]; other site 768494014757 peptide chain release factor 1; Validated; Region: prfA; PRK00591 768494014758 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768494014759 RF-1 domain; Region: RF-1; pfam00472 768494014760 thymidine kinase; Provisional; Region: PRK04296 768494014761 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 768494014762 transcription termination factor Rho; Provisional; Region: rho; PRK09376 768494014763 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 768494014764 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 768494014765 RNA binding site [nucleotide binding]; other site 768494014766 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 768494014767 multimer interface [polypeptide binding]; other site 768494014768 Walker A motif; other site 768494014769 ATP binding site [chemical binding]; other site 768494014770 Walker B motif; other site 768494014771 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 768494014772 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 768494014773 putative active site [active] 768494014774 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 768494014775 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 768494014776 hinge; other site 768494014777 active site 768494014778 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 768494014779 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768494014780 intersubunit interface [polypeptide binding]; other site 768494014781 active site 768494014782 zinc binding site [ion binding]; other site 768494014783 Na+ binding site [ion binding]; other site 768494014784 Response regulator receiver domain; Region: Response_reg; pfam00072 768494014785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494014786 active site 768494014787 phosphorylation site [posttranslational modification] 768494014788 intermolecular recognition site; other site 768494014789 dimerization interface [polypeptide binding]; other site 768494014790 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 768494014791 CTP synthetase; Validated; Region: pyrG; PRK05380 768494014792 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 768494014793 Catalytic site [active] 768494014794 active site 768494014795 UTP binding site [chemical binding]; other site 768494014796 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 768494014797 active site 768494014798 putative oxyanion hole; other site 768494014799 catalytic triad [active] 768494014800 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 768494014801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494014802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494014803 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768494014804 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 768494014805 FAD binding site [chemical binding]; other site 768494014806 homotetramer interface [polypeptide binding]; other site 768494014807 substrate binding pocket [chemical binding]; other site 768494014808 catalytic base [active] 768494014809 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768494014810 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 768494014811 FAD binding site [chemical binding]; other site 768494014812 homotetramer interface [polypeptide binding]; other site 768494014813 substrate binding pocket [chemical binding]; other site 768494014814 catalytic base [active] 768494014815 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 768494014816 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768494014817 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768494014818 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 768494014819 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768494014820 dimer interface [polypeptide binding]; other site 768494014821 active site 768494014822 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768494014823 4Fe-4S binding domain; Region: Fer4; cl02805 768494014824 Cysteine-rich domain; Region: CCG; pfam02754 768494014825 Cysteine-rich domain; Region: CCG; pfam02754 768494014826 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 768494014827 PLD-like domain; Region: PLDc_2; pfam13091 768494014828 putative active site [active] 768494014829 catalytic site [active] 768494014830 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 768494014831 PLD-like domain; Region: PLDc_2; pfam13091 768494014832 putative active site [active] 768494014833 catalytic site [active] 768494014834 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 768494014835 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 768494014836 PAS domain S-box; Region: sensory_box; TIGR00229 768494014837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494014838 putative active site [active] 768494014839 heme pocket [chemical binding]; other site 768494014840 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768494014841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768494014842 metal binding site [ion binding]; metal-binding site 768494014843 active site 768494014844 I-site; other site 768494014845 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768494014846 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 768494014847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768494014848 non-specific DNA binding site [nucleotide binding]; other site 768494014849 salt bridge; other site 768494014850 sequence-specific DNA binding site [nucleotide binding]; other site 768494014851 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768494014852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494014853 active site 768494014854 phosphorylation site [posttranslational modification] 768494014855 intermolecular recognition site; other site 768494014856 dimerization interface [polypeptide binding]; other site 768494014857 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768494014858 DNA binding residues [nucleotide binding] 768494014859 dimerization interface [polypeptide binding]; other site 768494014860 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 768494014861 Histidine kinase; Region: HisKA_3; pfam07730 768494014862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494014863 ATP binding site [chemical binding]; other site 768494014864 Mg2+ binding site [ion binding]; other site 768494014865 G-X-G motif; other site 768494014866 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 768494014867 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768494014868 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494014869 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768494014870 Walker A/P-loop; other site 768494014871 ATP binding site [chemical binding]; other site 768494014872 Q-loop/lid; other site 768494014873 ABC transporter signature motif; other site 768494014874 Walker B; other site 768494014875 D-loop; other site 768494014876 H-loop/switch region; other site 768494014877 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768494014878 active site 768494014879 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 768494014880 Collagen binding domain; Region: Collagen_bind; pfam05737 768494014881 Collagen binding domain; Region: Collagen_bind; pfam05737 768494014882 Collagen binding domain; Region: Collagen_bind; pfam05737 768494014883 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014884 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014885 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014886 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014887 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014888 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014889 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 768494014890 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014891 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014892 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014893 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 768494014894 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014895 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014896 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014897 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014898 Cna protein B-type domain; Region: Cna_B; pfam05738 768494014899 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 768494014900 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 768494014901 PA/protease or protease-like domain interface [polypeptide binding]; other site 768494014902 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 768494014903 Peptidase family M28; Region: Peptidase_M28; pfam04389 768494014904 metal binding site [ion binding]; metal-binding site 768494014905 RNA polymerase sigma factor; Provisional; Region: PRK12522 768494014906 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768494014907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768494014908 DNA binding residues [nucleotide binding] 768494014909 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 768494014910 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 768494014911 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 768494014912 active site 768494014913 HIGH motif; other site 768494014914 KMSK motif region; other site 768494014915 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 768494014916 tRNA binding surface [nucleotide binding]; other site 768494014917 anticodon binding site; other site 768494014918 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 768494014919 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 768494014920 putative dimer interface [polypeptide binding]; other site 768494014921 catalytic triad [active] 768494014922 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 768494014923 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 768494014924 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 768494014925 agmatinase; Region: agmatinase; TIGR01230 768494014926 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 768494014927 putative active site [active] 768494014928 Mn binding site [ion binding]; other site 768494014929 spermidine synthase; Provisional; Region: PRK00811 768494014930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494014931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494014932 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768494014933 putative substrate translocation pore; other site 768494014934 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 768494014935 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 768494014936 DNA binding residues [nucleotide binding] 768494014937 putative dimer interface [polypeptide binding]; other site 768494014938 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768494014939 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 768494014940 active site 768494014941 catalytic site [active] 768494014942 metal binding site [ion binding]; metal-binding site 768494014943 dimer interface [polypeptide binding]; other site 768494014944 Transglycosylase; Region: Transgly; pfam00912 768494014945 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 768494014946 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768494014947 YwhD family; Region: YwhD; pfam08741 768494014948 Peptidase family M50; Region: Peptidase_M50; pfam02163 768494014949 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 768494014950 active site 768494014951 putative substrate binding region [chemical binding]; other site 768494014952 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 768494014953 active site 1 [active] 768494014954 dimer interface [polypeptide binding]; other site 768494014955 hexamer interface [polypeptide binding]; other site 768494014956 active site 2 [active] 768494014957 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 768494014958 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768494014959 Zn2+ binding site [ion binding]; other site 768494014960 Mg2+ binding site [ion binding]; other site 768494014961 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 768494014962 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768494014963 intersubunit interface [polypeptide binding]; other site 768494014964 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768494014965 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768494014966 Walker A/P-loop; other site 768494014967 ATP binding site [chemical binding]; other site 768494014968 Q-loop/lid; other site 768494014969 ABC transporter signature motif; other site 768494014970 Walker B; other site 768494014971 D-loop; other site 768494014972 H-loop/switch region; other site 768494014973 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768494014974 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494014975 ABC-ATPase subunit interface; other site 768494014976 dimer interface [polypeptide binding]; other site 768494014977 putative PBP binding regions; other site 768494014978 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768494014979 dimer interface [polypeptide binding]; other site 768494014980 putative PBP binding regions; other site 768494014981 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768494014982 ABC-ATPase subunit interface; other site 768494014983 FecCD transport family; Region: FecCD; pfam01032 768494014984 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768494014985 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 768494014986 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 768494014987 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 768494014988 hypothetical protein; Provisional; Region: PRK12473 768494014989 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768494014990 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 768494014991 putative heme peroxidase; Provisional; Region: PRK12276 768494014992 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768494014993 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768494014994 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 768494014995 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 768494014996 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 768494014997 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 768494014998 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 768494014999 Ion channel; Region: Ion_trans_2; pfam07885 768494015000 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 768494015001 TrkA-N domain; Region: TrkA_N; pfam02254 768494015002 TrkA-C domain; Region: TrkA_C; pfam02080 768494015003 putative uracil/xanthine transporter; Provisional; Region: PRK11412 768494015004 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768494015005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494015006 motif II; other site 768494015007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494015008 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 768494015009 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 768494015010 ligand binding site [chemical binding]; other site 768494015011 active site 768494015012 UGI interface [polypeptide binding]; other site 768494015013 catalytic site [active] 768494015014 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 768494015015 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 768494015016 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 768494015017 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 768494015018 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768494015019 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 768494015020 Walker A/P-loop; other site 768494015021 ATP binding site [chemical binding]; other site 768494015022 Q-loop/lid; other site 768494015023 ABC transporter signature motif; other site 768494015024 Walker B; other site 768494015025 D-loop; other site 768494015026 H-loop/switch region; other site 768494015027 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 768494015028 active site 768494015029 catalytic triad [active] 768494015030 oxyanion hole [active] 768494015031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768494015032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768494015033 DNA binding site [nucleotide binding] 768494015034 domain linker motif; other site 768494015035 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 768494015036 putative dimerization interface [polypeptide binding]; other site 768494015037 putative ligand binding site [chemical binding]; other site 768494015038 Predicted membrane protein [Function unknown]; Region: COG2364 768494015039 potential frameshift: common BLAST hit: gi|227818172|ref|YP_002818181.1| homoserine dehydrogenase 768494015040 homoserine dehydrogenase; Provisional; Region: PRK06349 768494015041 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768494015042 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 768494015043 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768494015044 homoserine O-succinyltransferase; Provisional; Region: PRK05368 768494015045 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 768494015046 proposed active site lysine [active] 768494015047 conserved cys residue [active] 768494015048 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 768494015049 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768494015050 homodimer interface [polypeptide binding]; other site 768494015051 substrate-cofactor binding pocket; other site 768494015052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768494015053 catalytic residue [active] 768494015054 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768494015055 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 768494015056 Cl- selectivity filter; other site 768494015057 Cl- binding residues [ion binding]; other site 768494015058 pore gating glutamate residue; other site 768494015059 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 768494015060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768494015061 active site 768494015062 motif I; other site 768494015063 motif II; other site 768494015064 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 768494015065 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768494015066 ligand binding site [chemical binding]; other site 768494015067 flexible hinge region; other site 768494015068 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 768494015069 azoreductase; Provisional; Region: PRK13556 768494015070 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768494015071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494015072 active site 768494015073 phosphorylation site [posttranslational modification] 768494015074 intermolecular recognition site; other site 768494015075 dimerization interface [polypeptide binding]; other site 768494015076 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768494015077 DNA binding residues [nucleotide binding] 768494015078 dimerization interface [polypeptide binding]; other site 768494015079 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 768494015080 Histidine kinase; Region: HisKA_3; pfam07730 768494015081 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 768494015082 ATP binding site [chemical binding]; other site 768494015083 Mg2+ binding site [ion binding]; other site 768494015084 G-X-G motif; other site 768494015085 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 768494015086 GAF domain; Region: GAF; pfam01590 768494015087 GAF domain; Region: GAF_3; pfam13492 768494015088 GAF domain; Region: GAF_2; pfam13185 768494015089 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 768494015090 dimer interface [polypeptide binding]; other site 768494015091 substrate binding site [chemical binding]; other site 768494015092 ATP binding site [chemical binding]; other site 768494015093 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 768494015094 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768494015095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768494015096 metal binding site [ion binding]; metal-binding site 768494015097 active site 768494015098 I-site; other site 768494015099 Protein of unknown function (DUF466); Region: DUF466; pfam04328 768494015100 carbon starvation protein A; Provisional; Region: PRK15015 768494015101 Carbon starvation protein CstA; Region: CstA; pfam02554 768494015102 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 768494015103 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 768494015104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494015105 active site 768494015106 phosphorylation site [posttranslational modification] 768494015107 intermolecular recognition site; other site 768494015108 dimerization interface [polypeptide binding]; other site 768494015109 LytTr DNA-binding domain; Region: LytTR; pfam04397 768494015110 benzoate transport; Region: 2A0115; TIGR00895 768494015111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494015112 putative substrate translocation pore; other site 768494015113 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 768494015114 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 768494015115 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768494015116 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768494015117 Predicted membrane protein [Function unknown]; Region: COG2860 768494015118 UPF0126 domain; Region: UPF0126; pfam03458 768494015119 UPF0126 domain; Region: UPF0126; pfam03458 768494015120 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 768494015121 heme-binding site [chemical binding]; other site 768494015122 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768494015123 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768494015124 dimer interface [polypeptide binding]; other site 768494015125 putative CheW interface [polypeptide binding]; other site 768494015126 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 768494015127 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 768494015128 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768494015129 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 768494015130 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 768494015131 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768494015132 active site 768494015133 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768494015134 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494015135 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494015136 ABC transporter; Region: ABC_tran_2; pfam12848 768494015137 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768494015138 conserved hypothetical integral membrane protein; Region: TIGR03766 768494015139 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 768494015140 GtrA-like protein; Region: GtrA; pfam04138 768494015141 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 768494015142 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 768494015143 Ligand binding site; other site 768494015144 Putative Catalytic site; other site 768494015145 DXD motif; other site 768494015146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768494015147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768494015148 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768494015149 Protein export membrane protein; Region: SecD_SecF; cl14618 768494015150 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 768494015151 methionine sulfoxide reductase B; Provisional; Region: PRK00222 768494015152 SelR domain; Region: SelR; pfam01641 768494015153 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768494015154 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768494015155 antiholin-like protein LrgB; Provisional; Region: PRK04288 768494015156 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 768494015157 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 768494015158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494015159 active site 768494015160 phosphorylation site [posttranslational modification] 768494015161 intermolecular recognition site; other site 768494015162 dimerization interface [polypeptide binding]; other site 768494015163 LytTr DNA-binding domain; Region: LytTR; pfam04397 768494015164 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 768494015165 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 768494015166 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768494015167 Histidine kinase; Region: His_kinase; pfam06580 768494015168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494015169 ATP binding site [chemical binding]; other site 768494015170 Mg2+ binding site [ion binding]; other site 768494015171 G-X-G motif; other site 768494015172 benzoate transport; Region: 2A0115; TIGR00895 768494015173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768494015174 putative substrate translocation pore; other site 768494015175 BCCT family transporter; Region: BCCT; pfam02028 768494015176 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 768494015177 active site 768494015178 dimer interface [polypeptide binding]; other site 768494015179 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 768494015180 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 768494015181 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 768494015182 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768494015183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768494015184 NAD(P) binding site [chemical binding]; other site 768494015185 active site 768494015186 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 768494015187 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768494015188 UDP-glucose 4-epimerase; Region: PLN02240 768494015189 NAD binding site [chemical binding]; other site 768494015190 homodimer interface [polypeptide binding]; other site 768494015191 active site 768494015192 substrate binding site [chemical binding]; other site 768494015193 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 768494015194 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 768494015195 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 768494015196 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 768494015197 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768494015198 ATP binding site [chemical binding]; other site 768494015199 Mg++ binding site [ion binding]; other site 768494015200 motif III; other site 768494015201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768494015202 nucleotide binding region [chemical binding]; other site 768494015203 ATP-binding site [chemical binding]; other site 768494015204 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 768494015205 RNA binding site [nucleotide binding]; other site 768494015206 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 768494015207 Acyltransferase family; Region: Acyl_transf_3; pfam01757 768494015208 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 768494015209 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 768494015210 active site 768494015211 oligoendopeptidase F; Region: pepF; TIGR00181 768494015212 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 768494015213 active site 768494015214 Zn binding site [ion binding]; other site 768494015215 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 768494015216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768494015217 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 768494015218 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 768494015219 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 768494015220 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 768494015221 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768494015222 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768494015223 protein binding site [polypeptide binding]; other site 768494015224 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 768494015225 YycH protein; Region: YycI; pfam09648 768494015226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 768494015227 YycH protein; Region: YycH; pfam07435 768494015228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 768494015229 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768494015230 dimerization interface [polypeptide binding]; other site 768494015231 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768494015232 putative active site [active] 768494015233 heme pocket [chemical binding]; other site 768494015234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768494015235 dimer interface [polypeptide binding]; other site 768494015236 phosphorylation site [posttranslational modification] 768494015237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768494015238 ATP binding site [chemical binding]; other site 768494015239 Mg2+ binding site [ion binding]; other site 768494015240 G-X-G motif; other site 768494015241 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768494015242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768494015243 active site 768494015244 phosphorylation site [posttranslational modification] 768494015245 intermolecular recognition site; other site 768494015246 dimerization interface [polypeptide binding]; other site 768494015247 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768494015248 DNA binding site [nucleotide binding] 768494015249 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 768494015250 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 768494015251 GDP-binding site [chemical binding]; other site 768494015252 ACT binding site; other site 768494015253 IMP binding site; other site 768494015254 replicative DNA helicase; Provisional; Region: PRK05748 768494015255 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768494015256 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768494015257 Walker A motif; other site 768494015258 ATP binding site [chemical binding]; other site 768494015259 Walker B motif; other site 768494015260 DNA binding loops [nucleotide binding] 768494015261 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 768494015262 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 768494015263 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 768494015264 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 768494015265 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 768494015266 DHH family; Region: DHH; pfam01368 768494015267 DHHA1 domain; Region: DHHA1; pfam02272 768494015268 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 768494015269 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 768494015270 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 768494015271 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768494015272 dimer interface [polypeptide binding]; other site 768494015273 ssDNA binding site [nucleotide binding]; other site 768494015274 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768494015275 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 768494015276 GTP-binding protein YchF; Reviewed; Region: PRK09601 768494015277 YchF GTPase; Region: YchF; cd01900 768494015278 G1 box; other site 768494015279 GTP/Mg2+ binding site [chemical binding]; other site 768494015280 Switch I region; other site 768494015281 G2 box; other site 768494015282 Switch II region; other site 768494015283 G3 box; other site 768494015284 G4 box; other site 768494015285 G5 box; other site 768494015286 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 768494015287 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 768494015288 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 768494015289 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768494015290 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 768494015291 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 768494015292 ParB-like nuclease domain; Region: ParB; smart00470 768494015293 KorB domain; Region: KorB; pfam08535 768494015294 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768494015295 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768494015296 P-loop; other site 768494015297 Magnesium ion binding site [ion binding]; other site 768494015298 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768494015299 Magnesium ion binding site [ion binding]; other site 768494015300 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 768494015301 ParB-like nuclease domain; Region: ParBc; pfam02195 768494015302 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 768494015303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768494015304 S-adenosylmethionine binding site [chemical binding]; other site 768494015305 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 768494015306 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 768494015307 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 768494015308 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 768494015309 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 768494015310 trmE is a tRNA modification GTPase; Region: trmE; cd04164 768494015311 G1 box; other site 768494015312 GTP/Mg2+ binding site [chemical binding]; other site 768494015313 Switch I region; other site 768494015314 G2 box; other site 768494015315 Switch II region; other site 768494015316 G3 box; other site 768494015317 G4 box; other site 768494015318 G5 box; other site 768494015319 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 768494015320 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 768494015321 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 768494015322 G-X-X-G motif; other site 768494015323 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 768494015324 RxxxH motif; other site 768494015325 OxaA-like protein precursor; Validated; Region: PRK02944 768494015326 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 768494015327 ribonuclease P; Reviewed; Region: rnpA; PRK00499 768494015328 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399