-- dump date 20140618_210859 -- class Genbank::misc_feature -- table misc_feature_note -- id note 692420000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 692420000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 692420000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420000004 Walker A motif; other site 692420000005 ATP binding site [chemical binding]; other site 692420000006 Walker B motif; other site 692420000007 arginine finger; other site 692420000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 692420000009 DnaA box-binding interface [nucleotide binding]; other site 692420000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 692420000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 692420000012 putative DNA binding surface [nucleotide binding]; other site 692420000013 dimer interface [polypeptide binding]; other site 692420000014 beta-clamp/clamp loader binding surface; other site 692420000015 beta-clamp/translesion DNA polymerase binding surface; other site 692420000016 S4 domain; Region: S4_2; pfam13275 692420000017 recombination protein F; Reviewed; Region: recF; PRK00064 692420000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 692420000019 Walker A/P-loop; other site 692420000020 ATP binding site [chemical binding]; other site 692420000021 Q-loop/lid; other site 692420000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420000023 ABC transporter signature motif; other site 692420000024 Walker B; other site 692420000025 D-loop; other site 692420000026 H-loop/switch region; other site 692420000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 692420000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420000029 ATP binding site [chemical binding]; other site 692420000030 Mg2+ binding site [ion binding]; other site 692420000031 G-X-G motif; other site 692420000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 692420000033 anchoring element; other site 692420000034 dimer interface [polypeptide binding]; other site 692420000035 ATP binding site [chemical binding]; other site 692420000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 692420000037 active site 692420000038 putative metal-binding site [ion binding]; other site 692420000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 692420000040 DNA gyrase subunit A; Validated; Region: PRK05560 692420000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 692420000042 CAP-like domain; other site 692420000043 active site 692420000044 primary dimer interface [polypeptide binding]; other site 692420000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420000051 YaaC-like Protein; Region: YaaC; pfam14175 692420000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 692420000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 692420000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 692420000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 692420000056 active site 692420000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 692420000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 692420000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 692420000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 692420000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 692420000062 active site 692420000063 multimer interface [polypeptide binding]; other site 692420000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 692420000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 692420000066 predicted active site [active] 692420000067 catalytic triad [active] 692420000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 692420000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 692420000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 692420000071 dimer interface [polypeptide binding]; other site 692420000072 active site 692420000073 motif 1; other site 692420000074 motif 2; other site 692420000075 motif 3; other site 692420000076 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 692420000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 692420000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 692420000079 Substrate-binding site [chemical binding]; other site 692420000080 Substrate specificity [chemical binding]; other site 692420000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 692420000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 692420000083 Substrate-binding site [chemical binding]; other site 692420000084 Substrate specificity [chemical binding]; other site 692420000085 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 692420000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420000087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420000088 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 692420000089 active site 692420000090 Isochorismatase family; Region: Isochorismatase; pfam00857 692420000091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 692420000092 catalytic triad [active] 692420000093 conserved cis-peptide bond; other site 692420000094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 692420000095 nucleoside/Zn binding site; other site 692420000096 dimer interface [polypeptide binding]; other site 692420000097 catalytic motif [active] 692420000098 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 692420000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420000100 Walker A motif; other site 692420000101 ATP binding site [chemical binding]; other site 692420000102 Walker B motif; other site 692420000103 arginine finger; other site 692420000104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 692420000105 hypothetical protein; Validated; Region: PRK00153 692420000106 recombination protein RecR; Reviewed; Region: recR; PRK00076 692420000107 RecR protein; Region: RecR; pfam02132 692420000108 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 692420000109 putative active site [active] 692420000110 putative metal-binding site [ion binding]; other site 692420000111 tetramer interface [polypeptide binding]; other site 692420000112 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 692420000113 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 692420000114 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 692420000115 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 692420000116 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 692420000117 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 692420000118 homodimer interface [polypeptide binding]; other site 692420000119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420000120 catalytic residue [active] 692420000121 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 692420000122 thymidylate kinase; Validated; Region: tmk; PRK00698 692420000123 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 692420000124 TMP-binding site; other site 692420000125 ATP-binding site [chemical binding]; other site 692420000126 Protein of unknown function (DUF970); Region: DUF970; pfam06153 692420000127 Protein of unknown function (DUF327); Region: DUF327; pfam03885 692420000128 DNA polymerase III subunit delta'; Validated; Region: PRK08058 692420000129 DNA polymerase III subunit delta'; Validated; Region: PRK08485 692420000130 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 692420000131 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 692420000132 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 692420000133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420000134 S-adenosylmethionine binding site [chemical binding]; other site 692420000135 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 692420000136 GIY-YIG motif/motif A; other site 692420000137 putative active site [active] 692420000138 putative metal binding site [ion binding]; other site 692420000139 Predicted methyltransferases [General function prediction only]; Region: COG0313 692420000140 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 692420000141 putative SAM binding site [chemical binding]; other site 692420000142 putative homodimer interface [polypeptide binding]; other site 692420000143 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 692420000144 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 692420000145 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 692420000146 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 692420000147 active site 692420000148 HIGH motif; other site 692420000149 KMSKS motif; other site 692420000150 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 692420000151 tRNA binding surface [nucleotide binding]; other site 692420000152 anticodon binding site; other site 692420000153 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 692420000154 dimer interface [polypeptide binding]; other site 692420000155 putative tRNA-binding site [nucleotide binding]; other site 692420000156 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 692420000157 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 692420000158 active site 692420000159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 692420000160 Domain of unknown function (DUF348); Region: DUF348; pfam03990 692420000161 Domain of unknown function (DUF348); Region: DUF348; pfam03990 692420000162 Domain of unknown function (DUF348); Region: DUF348; pfam03990 692420000163 G5 domain; Region: G5; pfam07501 692420000164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 692420000165 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 692420000166 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 692420000167 putative active site [active] 692420000168 putative metal binding site [ion binding]; other site 692420000169 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 692420000170 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 692420000171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420000172 S-adenosylmethionine binding site [chemical binding]; other site 692420000173 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 692420000174 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 692420000175 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 692420000176 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 692420000177 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 692420000178 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 692420000179 pur operon repressor; Provisional; Region: PRK09213 692420000180 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 692420000181 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420000182 active site 692420000183 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 692420000184 homotrimer interaction site [polypeptide binding]; other site 692420000185 putative active site [active] 692420000186 regulatory protein SpoVG; Reviewed; Region: PRK13259 692420000187 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 692420000188 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 692420000189 Substrate binding site; other site 692420000190 Mg++ binding site; other site 692420000191 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 692420000192 active site 692420000193 substrate binding site [chemical binding]; other site 692420000194 CoA binding site [chemical binding]; other site 692420000195 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 692420000196 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 692420000197 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420000198 active site 692420000199 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 692420000200 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 692420000201 5S rRNA interface [nucleotide binding]; other site 692420000202 CTC domain interface [polypeptide binding]; other site 692420000203 L16 interface [polypeptide binding]; other site 692420000204 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 692420000205 putative active site [active] 692420000206 catalytic residue [active] 692420000207 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 692420000208 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 692420000209 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 692420000210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420000211 ATP binding site [chemical binding]; other site 692420000212 putative Mg++ binding site [ion binding]; other site 692420000213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420000214 nucleotide binding region [chemical binding]; other site 692420000215 ATP-binding site [chemical binding]; other site 692420000216 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 692420000217 stage V sporulation protein T; Region: spore_V_T; TIGR02851 692420000218 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 692420000219 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 692420000220 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 692420000221 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 692420000222 putative SAM binding site [chemical binding]; other site 692420000223 putative homodimer interface [polypeptide binding]; other site 692420000224 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 692420000225 homodimer interface [polypeptide binding]; other site 692420000226 metal binding site [ion binding]; metal-binding site 692420000227 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 692420000228 homodimer interface [polypeptide binding]; other site 692420000229 active site 692420000230 putative chemical substrate binding site [chemical binding]; other site 692420000231 metal binding site [ion binding]; metal-binding site 692420000232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420000233 RNA binding surface [nucleotide binding]; other site 692420000234 sporulation protein YabP; Region: spore_yabP; TIGR02892 692420000235 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 692420000236 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 692420000237 Septum formation initiator; Region: DivIC; pfam04977 692420000238 hypothetical protein; Provisional; Region: PRK08582 692420000239 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 692420000240 RNA binding site [nucleotide binding]; other site 692420000241 stage II sporulation protein E; Region: spore_II_E; TIGR02865 692420000242 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 692420000243 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 692420000244 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 692420000245 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 692420000246 metal ion-dependent adhesion site (MIDAS); other site 692420000247 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 692420000248 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420000249 active site 692420000250 ATP binding site [chemical binding]; other site 692420000251 substrate binding site [chemical binding]; other site 692420000252 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 692420000253 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 692420000254 Ligand Binding Site [chemical binding]; other site 692420000255 TilS substrate C-terminal domain; Region: TilS_C; smart00977 692420000256 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420000257 active site 692420000258 FtsH Extracellular; Region: FtsH_ext; pfam06480 692420000259 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 692420000260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420000261 Walker A motif; other site 692420000262 ATP binding site [chemical binding]; other site 692420000263 Walker B motif; other site 692420000264 arginine finger; other site 692420000265 Peptidase family M41; Region: Peptidase_M41; pfam01434 692420000266 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 692420000267 nucleotide binding site [chemical binding]; other site 692420000268 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 692420000269 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 692420000270 dimerization interface [polypeptide binding]; other site 692420000271 domain crossover interface; other site 692420000272 redox-dependent activation switch; other site 692420000273 SurA N-terminal domain; Region: SurA_N_3; cl07813 692420000274 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 692420000275 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 692420000276 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 692420000277 dimer interface [polypeptide binding]; other site 692420000278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420000279 catalytic residue [active] 692420000280 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 692420000281 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 692420000282 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 692420000283 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 692420000284 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 692420000285 glutamine binding [chemical binding]; other site 692420000286 catalytic triad [active] 692420000287 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 692420000288 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 692420000289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420000290 catalytic residue [active] 692420000291 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 692420000292 dihydropteroate synthase; Region: DHPS; TIGR01496 692420000293 substrate binding pocket [chemical binding]; other site 692420000294 dimer interface [polypeptide binding]; other site 692420000295 inhibitor binding site; inhibition site 692420000296 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 692420000297 homooctamer interface [polypeptide binding]; other site 692420000298 active site 692420000299 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 692420000300 catalytic center binding site [active] 692420000301 ATP binding site [chemical binding]; other site 692420000302 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 692420000303 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 692420000304 FMN binding site [chemical binding]; other site 692420000305 active site 692420000306 catalytic residues [active] 692420000307 substrate binding site [chemical binding]; other site 692420000308 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 692420000309 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 692420000310 dimer interface [polypeptide binding]; other site 692420000311 putative anticodon binding site; other site 692420000312 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 692420000313 motif 1; other site 692420000314 active site 692420000315 motif 2; other site 692420000316 motif 3; other site 692420000317 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 692420000318 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 692420000319 UvrB/uvrC motif; Region: UVR; pfam02151 692420000320 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 692420000321 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 692420000322 ADP binding site [chemical binding]; other site 692420000323 phosphagen binding site; other site 692420000324 substrate specificity loop; other site 692420000325 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 692420000326 Clp amino terminal domain; Region: Clp_N; pfam02861 692420000327 Clp amino terminal domain; Region: Clp_N; pfam02861 692420000328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420000329 Walker A motif; other site 692420000330 ATP binding site [chemical binding]; other site 692420000331 Walker B motif; other site 692420000332 arginine finger; other site 692420000333 UvrB/uvrC motif; Region: UVR; pfam02151 692420000334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420000335 Walker A motif; other site 692420000336 ATP binding site [chemical binding]; other site 692420000337 Walker B motif; other site 692420000338 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 692420000339 DNA repair protein RadA; Provisional; Region: PRK11823 692420000340 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 692420000341 Walker A motif/ATP binding site; other site 692420000342 ATP binding site [chemical binding]; other site 692420000343 Walker B motif; other site 692420000344 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 692420000345 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 692420000346 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 692420000347 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 692420000348 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 692420000349 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 692420000350 putative active site [active] 692420000351 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 692420000352 substrate binding site; other site 692420000353 dimer interface; other site 692420000354 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 692420000355 homotrimer interaction site [polypeptide binding]; other site 692420000356 zinc binding site [ion binding]; other site 692420000357 CDP-binding sites; other site 692420000358 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 692420000359 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 692420000360 HIGH motif; other site 692420000361 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 692420000362 active site 692420000363 KMSKS motif; other site 692420000364 serine O-acetyltransferase; Region: cysE; TIGR01172 692420000365 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 692420000366 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 692420000367 trimer interface [polypeptide binding]; other site 692420000368 active site 692420000369 substrate binding site [chemical binding]; other site 692420000370 CoA binding site [chemical binding]; other site 692420000371 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 692420000372 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 692420000373 active site 692420000374 HIGH motif; other site 692420000375 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 692420000376 KMSKS motif; other site 692420000377 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 692420000378 tRNA binding surface [nucleotide binding]; other site 692420000379 anticodon binding site; other site 692420000380 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 692420000381 active site 692420000382 metal binding site [ion binding]; metal-binding site 692420000383 dimerization interface [polypeptide binding]; other site 692420000384 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 692420000385 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 692420000386 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 692420000387 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 692420000388 RNA polymerase factor sigma-70; Validated; Region: PRK08295 692420000389 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420000390 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 692420000391 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 692420000392 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 692420000393 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 692420000394 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 692420000395 putative homodimer interface [polypeptide binding]; other site 692420000396 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 692420000397 heterodimer interface [polypeptide binding]; other site 692420000398 homodimer interface [polypeptide binding]; other site 692420000399 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 692420000400 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 692420000401 23S rRNA interface [nucleotide binding]; other site 692420000402 L7/L12 interface [polypeptide binding]; other site 692420000403 putative thiostrepton binding site; other site 692420000404 L25 interface [polypeptide binding]; other site 692420000405 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 692420000406 mRNA/rRNA interface [nucleotide binding]; other site 692420000407 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 692420000408 23S rRNA interface [nucleotide binding]; other site 692420000409 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 692420000410 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 692420000411 core dimer interface [polypeptide binding]; other site 692420000412 peripheral dimer interface [polypeptide binding]; other site 692420000413 L10 interface [polypeptide binding]; other site 692420000414 L11 interface [polypeptide binding]; other site 692420000415 putative EF-Tu interaction site [polypeptide binding]; other site 692420000416 putative EF-G interaction site [polypeptide binding]; other site 692420000417 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 692420000418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420000419 S-adenosylmethionine binding site [chemical binding]; other site 692420000420 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 692420000421 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 692420000422 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 692420000423 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 692420000424 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 692420000425 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 692420000426 RPB1 interaction site [polypeptide binding]; other site 692420000427 RPB10 interaction site [polypeptide binding]; other site 692420000428 RPB11 interaction site [polypeptide binding]; other site 692420000429 RPB3 interaction site [polypeptide binding]; other site 692420000430 RPB12 interaction site [polypeptide binding]; other site 692420000431 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 692420000432 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 692420000433 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 692420000434 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 692420000435 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 692420000436 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 692420000437 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 692420000438 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 692420000439 G-loop; other site 692420000440 DNA binding site [nucleotide binding] 692420000441 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 692420000442 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 692420000443 S17 interaction site [polypeptide binding]; other site 692420000444 S8 interaction site; other site 692420000445 16S rRNA interaction site [nucleotide binding]; other site 692420000446 streptomycin interaction site [chemical binding]; other site 692420000447 23S rRNA interaction site [nucleotide binding]; other site 692420000448 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 692420000449 30S ribosomal protein S7; Validated; Region: PRK05302 692420000450 elongation factor G; Reviewed; Region: PRK00007 692420000451 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 692420000452 G1 box; other site 692420000453 putative GEF interaction site [polypeptide binding]; other site 692420000454 GTP/Mg2+ binding site [chemical binding]; other site 692420000455 Switch I region; other site 692420000456 G2 box; other site 692420000457 G3 box; other site 692420000458 Switch II region; other site 692420000459 G4 box; other site 692420000460 G5 box; other site 692420000461 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 692420000462 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 692420000463 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 692420000464 elongation factor Tu; Reviewed; Region: PRK00049 692420000465 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 692420000466 G1 box; other site 692420000467 GEF interaction site [polypeptide binding]; other site 692420000468 GTP/Mg2+ binding site [chemical binding]; other site 692420000469 Switch I region; other site 692420000470 G2 box; other site 692420000471 G3 box; other site 692420000472 Switch II region; other site 692420000473 G4 box; other site 692420000474 G5 box; other site 692420000475 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 692420000476 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 692420000477 Antibiotic Binding Site [chemical binding]; other site 692420000478 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 692420000479 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 692420000480 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 692420000481 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 692420000482 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 692420000483 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 692420000484 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 692420000485 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 692420000486 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 692420000487 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 692420000488 putative translocon binding site; other site 692420000489 protein-rRNA interface [nucleotide binding]; other site 692420000490 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 692420000491 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 692420000492 G-X-X-G motif; other site 692420000493 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 692420000494 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 692420000495 23S rRNA interface [nucleotide binding]; other site 692420000496 5S rRNA interface [nucleotide binding]; other site 692420000497 putative antibiotic binding site [chemical binding]; other site 692420000498 L25 interface [polypeptide binding]; other site 692420000499 L27 interface [polypeptide binding]; other site 692420000500 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 692420000501 23S rRNA interface [nucleotide binding]; other site 692420000502 putative translocon interaction site; other site 692420000503 signal recognition particle (SRP54) interaction site; other site 692420000504 L23 interface [polypeptide binding]; other site 692420000505 trigger factor interaction site; other site 692420000506 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 692420000507 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 692420000508 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 692420000509 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 692420000510 RNA binding site [nucleotide binding]; other site 692420000511 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 692420000512 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 692420000513 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 692420000514 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 692420000515 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 692420000516 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 692420000517 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 692420000518 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 692420000519 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 692420000520 5S rRNA interface [nucleotide binding]; other site 692420000521 L27 interface [polypeptide binding]; other site 692420000522 23S rRNA interface [nucleotide binding]; other site 692420000523 L5 interface [polypeptide binding]; other site 692420000524 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 692420000525 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 692420000526 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 692420000527 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 692420000528 23S rRNA binding site [nucleotide binding]; other site 692420000529 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 692420000530 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 692420000531 SecY translocase; Region: SecY; pfam00344 692420000532 adenylate kinase; Reviewed; Region: adk; PRK00279 692420000533 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 692420000534 AMP-binding site [chemical binding]; other site 692420000535 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 692420000536 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 692420000537 active site 692420000538 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 692420000539 rRNA binding site [nucleotide binding]; other site 692420000540 predicted 30S ribosome binding site; other site 692420000541 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 692420000542 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 692420000543 30S ribosomal protein S13; Region: bact_S13; TIGR03631 692420000544 30S ribosomal protein S11; Validated; Region: PRK05309 692420000545 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 692420000546 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 692420000547 alphaNTD homodimer interface [polypeptide binding]; other site 692420000548 alphaNTD - beta interaction site [polypeptide binding]; other site 692420000549 alphaNTD - beta' interaction site [polypeptide binding]; other site 692420000550 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 692420000551 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 692420000552 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 692420000553 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 692420000554 Walker A/P-loop; other site 692420000555 ATP binding site [chemical binding]; other site 692420000556 Q-loop/lid; other site 692420000557 ABC transporter signature motif; other site 692420000558 Walker B; other site 692420000559 D-loop; other site 692420000560 H-loop/switch region; other site 692420000561 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 692420000562 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 692420000563 Walker A/P-loop; other site 692420000564 ATP binding site [chemical binding]; other site 692420000565 Q-loop/lid; other site 692420000566 ABC transporter signature motif; other site 692420000567 Walker B; other site 692420000568 D-loop; other site 692420000569 H-loop/switch region; other site 692420000570 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 692420000571 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 692420000572 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 692420000573 dimerization interface 3.5A [polypeptide binding]; other site 692420000574 active site 692420000575 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 692420000576 23S rRNA interface [nucleotide binding]; other site 692420000577 L3 interface [polypeptide binding]; other site 692420000578 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 692420000579 Methyltransferase domain; Region: Methyltransf_31; pfam13847 692420000580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420000581 S-adenosylmethionine binding site [chemical binding]; other site 692420000582 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 692420000583 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 692420000584 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 692420000585 active site 692420000586 metal binding site [ion binding]; metal-binding site 692420000587 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 692420000588 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 692420000589 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 692420000590 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 692420000591 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 692420000592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000593 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 692420000594 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420000595 inhibitor-cofactor binding pocket; inhibition site 692420000596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420000597 catalytic residue [active] 692420000598 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 692420000599 active site 692420000600 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 692420000601 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 692420000602 NAD(P) binding site [chemical binding]; other site 692420000603 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 692420000604 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 692420000605 Sulfate transporter family; Region: Sulfate_transp; pfam00916 692420000606 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 692420000607 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 692420000608 Sodium Bile acid symporter family; Region: SBF; cl17470 692420000609 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 692420000610 Putative esterase; Region: Esterase; pfam00756 692420000611 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 692420000612 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420000613 ABC-ATPase subunit interface; other site 692420000614 dimer interface [polypeptide binding]; other site 692420000615 putative PBP binding regions; other site 692420000616 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 692420000617 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420000618 ABC-ATPase subunit interface; other site 692420000619 dimer interface [polypeptide binding]; other site 692420000620 putative PBP binding regions; other site 692420000621 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 692420000622 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 692420000623 putative ligand binding residues [chemical binding]; other site 692420000624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420000625 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 692420000626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420000627 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 692420000628 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 692420000629 intersubunit interface [polypeptide binding]; other site 692420000630 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 692420000631 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 692420000632 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 692420000633 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 692420000634 putative periplasmic esterase; Provisional; Region: PRK03642 692420000635 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 692420000636 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 692420000637 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420000638 active site turn [active] 692420000639 phosphorylation site [posttranslational modification] 692420000640 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 692420000641 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 692420000642 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 692420000643 putative active site [active] 692420000644 Uncharacterized conserved protein [Function unknown]; Region: COG1683 692420000645 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 692420000646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420000647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420000648 DNA binding residues [nucleotide binding] 692420000649 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 692420000650 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 692420000651 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 692420000652 Uncharacterized conserved protein [Function unknown]; Region: COG1624 692420000653 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 692420000654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 692420000655 YbbR-like protein; Region: YbbR; pfam07949 692420000656 YbbR-like protein; Region: YbbR; pfam07949 692420000657 YbbR-like protein; Region: YbbR; pfam07949 692420000658 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 692420000659 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 692420000660 active site 692420000661 substrate binding site [chemical binding]; other site 692420000662 metal binding site [ion binding]; metal-binding site 692420000663 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 692420000664 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 692420000665 glutaminase active site [active] 692420000666 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 692420000667 dimer interface [polypeptide binding]; other site 692420000668 active site 692420000669 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 692420000670 dimer interface [polypeptide binding]; other site 692420000671 active site 692420000672 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 692420000673 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420000674 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420000675 active site 692420000676 catalytic tetrad [active] 692420000677 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 692420000678 holin-like protein; Validated; Region: PRK01658 692420000679 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420000680 MarR family; Region: MarR; pfam01047 692420000681 putative transport protein YifK; Provisional; Region: PRK10746 692420000682 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 692420000683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420000684 active site 692420000685 motif I; other site 692420000686 motif II; other site 692420000687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 692420000688 Histidine kinase; Region: HisKA_3; pfam07730 692420000689 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 692420000690 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420000691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420000692 active site 692420000693 phosphorylation site [posttranslational modification] 692420000694 intermolecular recognition site; other site 692420000695 dimerization interface [polypeptide binding]; other site 692420000696 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420000697 DNA binding residues [nucleotide binding] 692420000698 dimerization interface [polypeptide binding]; other site 692420000699 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420000700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420000701 Walker A/P-loop; other site 692420000702 ATP binding site [chemical binding]; other site 692420000703 Q-loop/lid; other site 692420000704 ABC transporter signature motif; other site 692420000705 Walker B; other site 692420000706 D-loop; other site 692420000707 H-loop/switch region; other site 692420000708 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 692420000709 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 692420000710 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 692420000711 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 692420000712 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 692420000713 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 692420000714 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 692420000715 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 692420000716 active site 692420000717 catalytic site [active] 692420000718 metal binding site [ion binding]; metal-binding site 692420000719 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 692420000720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000721 putative substrate translocation pore; other site 692420000722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000723 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 692420000724 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 692420000725 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 692420000726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420000727 non-specific DNA binding site [nucleotide binding]; other site 692420000728 salt bridge; other site 692420000729 sequence-specific DNA binding site [nucleotide binding]; other site 692420000730 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 692420000731 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 692420000732 active site 692420000733 NAD binding site [chemical binding]; other site 692420000734 metal binding site [ion binding]; metal-binding site 692420000735 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 692420000736 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420000737 ATP-grasp domain; Region: ATP-grasp; pfam02222 692420000738 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 692420000739 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 692420000740 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 692420000741 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 692420000742 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 692420000743 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 692420000744 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 692420000745 active site residue [active] 692420000746 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 692420000747 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 692420000748 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 692420000749 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 692420000750 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 692420000751 homodimer interface [polypeptide binding]; other site 692420000752 substrate-cofactor binding pocket; other site 692420000753 catalytic residue [active] 692420000754 S-methylmethionine transporter; Provisional; Region: PRK11387 692420000755 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 692420000756 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 692420000757 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 692420000758 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 692420000759 potential frameshift: common BLAST hit: gi|154684749|ref|YP_001419910.1| glutaminase 692420000760 Glutaminase; Region: Glutaminase; cl00907 692420000761 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 692420000762 similar to glutaminase fragment; Glutaminase 1;, Glutaminase 692420000763 similar to glutaminase fragment; Glutaminase 692420000764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420000765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420000766 ATP binding site [chemical binding]; other site 692420000767 Mg2+ binding site [ion binding]; other site 692420000768 G-X-G motif; other site 692420000769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420000770 Response regulator receiver domain; Region: Response_reg; pfam00072 692420000771 active site 692420000772 phosphorylation site [posttranslational modification] 692420000773 intermolecular recognition site; other site 692420000774 dimerization interface [polypeptide binding]; other site 692420000775 YcbB domain; Region: YcbB; pfam08664 692420000776 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 692420000777 putative active site [active] 692420000778 putative substrate binding site [chemical binding]; other site 692420000779 Phosphotransferase enzyme family; Region: APH; pfam01636 692420000780 ATP binding site [chemical binding]; other site 692420000781 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 692420000782 dodecamer interface 1 [polypeptide binding]; other site 692420000783 dodecamer interface 2 [polypeptide binding]; other site 692420000784 trimer interface [polypeptide binding]; other site 692420000785 TRAP binding interface [polypeptide binding]; other site 692420000786 Zn binding site [ion binding]; other site 692420000787 similar to ISBma2, transposase fragment 692420000788 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 692420000789 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 692420000790 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 692420000791 dimer interface [polypeptide binding]; other site 692420000792 FMN binding site [chemical binding]; other site 692420000793 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 692420000794 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420000795 Zn binding site [ion binding]; other site 692420000796 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 692420000797 Zn binding site [ion binding]; other site 692420000798 Predicted membrane protein [Function unknown]; Region: COG2259 692420000799 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 692420000800 catalytic residues [active] 692420000801 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 692420000802 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 692420000803 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 692420000804 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 692420000805 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 692420000806 putative active site [active] 692420000807 putative metal binding site [ion binding]; other site 692420000808 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 692420000809 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 692420000810 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 692420000811 putative substrate binding pocket [chemical binding]; other site 692420000812 AC domain interface; other site 692420000813 catalytic triad [active] 692420000814 AB domain interface; other site 692420000815 interchain disulfide; other site 692420000816 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 692420000817 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 692420000818 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420000819 catalytic residue [active] 692420000820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000821 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420000822 putative substrate translocation pore; other site 692420000823 potential frameshift: common BLAST hit: gi|154684770|ref|YP_001419931.1| Lip 692420000824 potential frameshift: common BLAST hit: gi|154684770|ref|YP_001419931.1| Lip; similar to lipase fragment 692420000825 similar to lipase fragment 692420000826 similar to lipase fragment 692420000827 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 692420000828 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 692420000829 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420000830 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420000831 active site 692420000832 catalytic tetrad [active] 692420000833 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 692420000834 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 692420000835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420000836 binding surface 692420000837 TPR motif; other site 692420000838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420000839 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420000840 TPR motif; other site 692420000841 binding surface 692420000842 glucose-1-dehydrogenase; Provisional; Region: PRK08936 692420000843 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 692420000844 NAD binding site [chemical binding]; other site 692420000845 homodimer interface [polypeptide binding]; other site 692420000846 active site 692420000847 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 692420000848 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 692420000849 Ca binding site [ion binding]; other site 692420000850 active site 692420000851 catalytic site [active] 692420000852 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 692420000853 Predicted transcriptional regulators [Transcription]; Region: COG1695 692420000854 Transcriptional regulator PadR-like family; Region: PadR; cl17335 692420000855 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 692420000856 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 692420000857 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 692420000858 metal binding site [ion binding]; metal-binding site 692420000859 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 692420000860 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 692420000861 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 692420000862 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420000863 ABC-ATPase subunit interface; other site 692420000864 dimer interface [polypeptide binding]; other site 692420000865 putative PBP binding regions; other site 692420000866 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 692420000867 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 692420000868 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 692420000869 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 692420000870 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 692420000871 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 692420000872 putative metal binding site [ion binding]; other site 692420000873 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 692420000874 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 692420000875 putative metal binding site [ion binding]; other site 692420000876 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 692420000877 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 692420000878 putative metal binding site [ion binding]; other site 692420000879 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 692420000880 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 692420000881 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 692420000882 benzoate transport; Region: 2A0115; TIGR00895 692420000883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000884 putative substrate translocation pore; other site 692420000885 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 692420000886 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 692420000887 Walker A/P-loop; other site 692420000888 ATP binding site [chemical binding]; other site 692420000889 Q-loop/lid; other site 692420000890 ABC transporter signature motif; other site 692420000891 Walker B; other site 692420000892 D-loop; other site 692420000893 H-loop/switch region; other site 692420000894 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 692420000895 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 692420000896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420000897 dimer interface [polypeptide binding]; other site 692420000898 conserved gate region; other site 692420000899 putative PBP binding loops; other site 692420000900 ABC-ATPase subunit interface; other site 692420000901 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 692420000902 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 692420000903 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 692420000904 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 692420000905 amidohydrolase; Region: amidohydrolases; TIGR01891 692420000906 metal binding site [ion binding]; metal-binding site 692420000907 putative dimer interface [polypeptide binding]; other site 692420000908 potential frameshift: common BLAST hit: gi|154684795|ref|YP_001419956.1| YcgA 692420000909 Predicted membrane protein [Function unknown]; Region: COG1288 692420000910 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 692420000911 RDD family; Region: RDD; pfam06271 692420000912 RDD family; Region: RDD; pfam06271 692420000913 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 692420000914 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 692420000915 tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420000916 NAD binding site [chemical binding]; other site 692420000917 dimer interface [polypeptide binding]; other site 692420000918 substrate binding site [chemical binding]; other site 692420000919 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 692420000920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000921 putative substrate translocation pore; other site 692420000922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420000923 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420000924 MarR family; Region: MarR; pfam01047 692420000925 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 692420000926 potential frameshift: common BLAST hit: gi|154684801|ref|YP_001419962.1| YcgF 692420000927 similar to amino acid efflux protein ycgF fragment; amino acid efflux protein ycgF;, Lysine exporter protein (LYSE/YGGA) 692420000928 similar to amino acid efflux protein ycgF fragment; amino acid efflux protein ycgF;, Lysine exporter protein (LYSE/YGGA) 692420000929 Uncharacterized conserved protein [Function unknown]; Region: COG3403 692420000930 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 692420000931 Spore germination protein; Region: Spore_permease; cl17796 692420000932 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 692420000933 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 692420000934 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 692420000935 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 692420000936 homodimer interface [polypeptide binding]; other site 692420000937 NAD binding pocket [chemical binding]; other site 692420000938 ATP binding pocket [chemical binding]; other site 692420000939 Mg binding site [ion binding]; other site 692420000940 active-site loop [active] 692420000941 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 692420000942 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 692420000943 similar to galactarate/glucarate transporter in (proton symport); Vesicular glutamate transporter 3; VGluT3; Solute carrier family 17 member 8;, Major facilitator superfamily MFS-1 692420000944 similar to galactarate/glucarate transporter in (proton symport) fragment; glucarate transporter; D-glucarate permease;, Major facilitator superfamily MFS-1 692420000945 shikimate kinase; Reviewed; Region: aroK; PRK00131 692420000946 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 692420000947 ADP binding site [chemical binding]; other site 692420000948 magnesium binding site [ion binding]; other site 692420000949 putative shikimate binding site; other site 692420000950 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 692420000951 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 692420000952 Proline dehydrogenase; Region: Pro_dh; pfam01619 692420000953 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 692420000954 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 692420000955 Glutamate binding site [chemical binding]; other site 692420000956 homodimer interface [polypeptide binding]; other site 692420000957 NAD binding site [chemical binding]; other site 692420000958 catalytic residues [active] 692420000959 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 692420000960 Na binding site [ion binding]; other site 692420000961 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 692420000962 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 692420000963 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 692420000964 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 692420000965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420000966 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 692420000967 active site 692420000968 SAM binding site [chemical binding]; other site 692420000969 homodimer interface [polypeptide binding]; other site 692420000970 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 692420000971 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 692420000972 [2Fe-2S] cluster binding site [ion binding]; other site 692420000973 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 692420000974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420000975 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 692420000976 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 692420000977 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 692420000978 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 692420000979 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 692420000980 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 692420000981 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 692420000982 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 692420000983 NAD binding site [chemical binding]; other site 692420000984 catalytic Zn binding site [ion binding]; other site 692420000985 structural Zn binding site [ion binding]; other site 692420000986 RDD family; Region: RDD; pfam06271 692420000987 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 692420000988 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 692420000989 beta-galactosidase; Region: BGL; TIGR03356 692420000990 Competence protein J (ComJ); Region: ComJ; pfam11033 692420000991 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 692420000992 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 692420000993 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 692420000994 tetramer interface [polypeptide binding]; other site 692420000995 active site 692420000996 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 692420000997 active site 692420000998 dimer interface [polypeptide binding]; other site 692420000999 magnesium binding site [ion binding]; other site 692420001000 Predicted transcriptional regulators [Transcription]; Region: COG1733 692420001001 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 692420001002 Condensation domain; Region: Condensation; pfam00668 692420001003 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420001004 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420001005 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420001006 acyl-activating enzyme (AAE) consensus motif; other site 692420001007 AMP binding site [chemical binding]; other site 692420001008 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420001009 Condensation domain; Region: Condensation; pfam00668 692420001010 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420001011 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420001012 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 692420001013 acyl-activating enzyme (AAE) consensus motif; other site 692420001014 AMP binding site [chemical binding]; other site 692420001015 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420001016 Condensation domain; Region: Condensation; pfam00668 692420001017 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420001018 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420001019 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420001020 acyl-activating enzyme (AAE) consensus motif; other site 692420001021 AMP binding site [chemical binding]; other site 692420001022 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420001023 Condensation domain; Region: Condensation; pfam00668 692420001024 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 692420001025 Condensation domain; Region: Condensation; pfam00668 692420001026 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420001027 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 692420001028 acyl-activating enzyme (AAE) consensus motif; other site 692420001029 AMP binding site [chemical binding]; other site 692420001030 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420001031 Condensation domain; Region: Condensation; pfam00668 692420001032 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420001033 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420001034 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420001035 acyl-activating enzyme (AAE) consensus motif; other site 692420001036 AMP binding site [chemical binding]; other site 692420001037 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420001038 Condensation domain; Region: Condensation; pfam00668 692420001039 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420001040 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420001041 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420001042 acyl-activating enzyme (AAE) consensus motif; other site 692420001043 AMP binding site [chemical binding]; other site 692420001044 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420001045 Condensation domain; Region: Condensation; pfam00668 692420001046 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420001047 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 692420001048 Condensation domain; Region: Condensation; pfam00668 692420001049 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420001050 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 692420001051 acyl-activating enzyme (AAE) consensus motif; other site 692420001052 AMP binding site [chemical binding]; other site 692420001053 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420001054 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 692420001055 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 692420001056 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 692420001057 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 692420001058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420001059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420001060 homodimer interface [polypeptide binding]; other site 692420001061 catalytic residue [active] 692420001062 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 692420001063 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 692420001064 Predicted membrane protein [Function unknown]; Region: COG2364 692420001065 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420001066 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 692420001067 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 692420001068 Walker A/P-loop; other site 692420001069 ATP binding site [chemical binding]; other site 692420001070 Q-loop/lid; other site 692420001071 ABC transporter signature motif; other site 692420001072 Walker B; other site 692420001073 D-loop; other site 692420001074 H-loop/switch region; other site 692420001075 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 692420001076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420001077 dimer interface [polypeptide binding]; other site 692420001078 conserved gate region; other site 692420001079 putative PBP binding loops; other site 692420001080 ABC-ATPase subunit interface; other site 692420001081 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 692420001082 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420001083 substrate binding pocket [chemical binding]; other site 692420001084 membrane-bound complex binding site; other site 692420001085 hinge residues; other site 692420001086 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420001087 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 692420001088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420001089 dimerization interface [polypeptide binding]; other site 692420001090 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 692420001091 Flavoprotein; Region: Flavoprotein; pfam02441 692420001092 UbiD family decarboxylase; Region: TIGR00148 692420001093 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 692420001094 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 692420001095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001096 putative substrate translocation pore; other site 692420001097 POT family; Region: PTR2; pfam00854 692420001098 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 692420001099 Right handed beta helix region; Region: Beta_helix; pfam13229 692420001100 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 692420001101 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 692420001102 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 692420001103 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 692420001104 Spore germination protein; Region: Spore_permease; pfam03845 692420001105 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 692420001106 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 692420001107 active site 692420001108 non-prolyl cis peptide bond; other site 692420001109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420001110 Coenzyme A binding pocket [chemical binding]; other site 692420001111 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 692420001112 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420001113 substrate binding pocket [chemical binding]; other site 692420001114 membrane-bound complex binding site; other site 692420001115 hinge residues; other site 692420001116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420001117 dimer interface [polypeptide binding]; other site 692420001118 conserved gate region; other site 692420001119 putative PBP binding loops; other site 692420001120 ABC-ATPase subunit interface; other site 692420001121 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 692420001122 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 692420001123 Walker A/P-loop; other site 692420001124 ATP binding site [chemical binding]; other site 692420001125 Q-loop/lid; other site 692420001126 ABC transporter signature motif; other site 692420001127 Walker B; other site 692420001128 D-loop; other site 692420001129 H-loop/switch region; other site 692420001130 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 692420001131 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 692420001132 metal binding site [ion binding]; metal-binding site 692420001133 dimer interface [polypeptide binding]; other site 692420001134 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 692420001135 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 692420001136 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 692420001137 Walker A/P-loop; other site 692420001138 ATP binding site [chemical binding]; other site 692420001139 Q-loop/lid; other site 692420001140 ABC transporter signature motif; other site 692420001141 Walker B; other site 692420001142 D-loop; other site 692420001143 H-loop/switch region; other site 692420001144 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 692420001145 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 692420001146 FtsX-like permease family; Region: FtsX; pfam02687 692420001147 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420001148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420001149 active site 692420001150 phosphorylation site [posttranslational modification] 692420001151 intermolecular recognition site; other site 692420001152 dimerization interface [polypeptide binding]; other site 692420001153 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420001154 DNA binding site [nucleotide binding] 692420001155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420001156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420001157 dimerization interface [polypeptide binding]; other site 692420001158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420001159 dimer interface [polypeptide binding]; other site 692420001160 phosphorylation site [posttranslational modification] 692420001161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420001162 ATP binding site [chemical binding]; other site 692420001163 Mg2+ binding site [ion binding]; other site 692420001164 G-X-G motif; other site 692420001165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420001166 binding surface 692420001167 TPR motif; other site 692420001168 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420001169 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420001170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420001171 TPR motif; other site 692420001172 binding surface 692420001173 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420001174 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 692420001175 aspartate kinase; Reviewed; Region: PRK09034 692420001176 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 692420001177 putative catalytic residues [active] 692420001178 putative nucleotide binding site [chemical binding]; other site 692420001179 putative aspartate binding site [chemical binding]; other site 692420001180 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 692420001181 allosteric regulatory residue; other site 692420001182 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 692420001183 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 692420001184 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420001185 ABC-ATPase subunit interface; other site 692420001186 dimer interface [polypeptide binding]; other site 692420001187 putative PBP binding regions; other site 692420001188 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420001189 ABC-ATPase subunit interface; other site 692420001190 dimer interface [polypeptide binding]; other site 692420001191 putative PBP binding regions; other site 692420001192 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 692420001193 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 692420001194 Walker A/P-loop; other site 692420001195 ATP binding site [chemical binding]; other site 692420001196 Q-loop/lid; other site 692420001197 ABC transporter signature motif; other site 692420001198 Walker B; other site 692420001199 D-loop; other site 692420001200 H-loop/switch region; other site 692420001201 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 692420001202 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 692420001203 putative ligand binding residues [chemical binding]; other site 692420001204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420001206 putative substrate translocation pore; other site 692420001207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420001209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420001210 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 692420001211 dimer interface [polypeptide binding]; other site 692420001212 FMN binding site [chemical binding]; other site 692420001213 NADPH bind site [chemical binding]; other site 692420001214 Uncharacterized conserved protein [Function unknown]; Region: COG1359 692420001215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420001216 dimerization interface [polypeptide binding]; other site 692420001217 putative DNA binding site [nucleotide binding]; other site 692420001218 putative Zn2+ binding site [ion binding]; other site 692420001219 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 692420001220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001221 DNA-binding site [nucleotide binding]; DNA binding site 692420001222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420001223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420001224 homodimer interface [polypeptide binding]; other site 692420001225 catalytic residue [active] 692420001226 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 692420001227 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420001228 inhibitor-cofactor binding pocket; inhibition site 692420001229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420001230 catalytic residue [active] 692420001231 succinic semialdehyde dehydrogenase; Region: PLN02278 692420001232 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 692420001233 tetramerization interface [polypeptide binding]; other site 692420001234 NAD(P) binding site [chemical binding]; other site 692420001235 catalytic residues [active] 692420001236 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 692420001237 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 692420001238 glucose-1-dehydrogenase; Provisional; Region: PRK08936 692420001239 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 692420001240 NAD binding site [chemical binding]; other site 692420001241 homodimer interface [polypeptide binding]; other site 692420001242 active site 692420001243 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 692420001244 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 692420001245 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 692420001246 YtkA-like; Region: YtkA; pfam13115 692420001247 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 692420001248 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 692420001249 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 692420001250 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 692420001251 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 692420001252 active site 692420001253 P-loop; other site 692420001254 phosphorylation site [posttranslational modification] 692420001255 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 692420001256 active site 692420001257 phosphorylation site [posttranslational modification] 692420001258 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 692420001259 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 692420001260 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 692420001261 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 692420001262 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 692420001263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420001264 active site 692420001265 motif I; other site 692420001266 motif II; other site 692420001267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420001268 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 692420001269 putative active site [active] 692420001270 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 692420001271 hypothetical protein; Provisional; Region: PRK05463 692420001272 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 692420001273 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 692420001274 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 692420001275 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 692420001276 Transcriptional regulator [Transcription]; Region: IclR; COG1414 692420001277 Bacterial transcriptional regulator; Region: IclR; pfam01614 692420001278 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 692420001279 active site 692420001280 catalytic triad [active] 692420001281 oxyanion hole [active] 692420001282 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 692420001283 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 692420001284 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 692420001285 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 692420001286 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420001287 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 692420001288 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420001289 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420001290 active site 692420001291 catalytic tetrad [active] 692420001292 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 692420001293 HTH domain; Region: HTH_11; pfam08279 692420001294 HTH domain; Region: HTH_11; cl17392 692420001295 PRD domain; Region: PRD; pfam00874 692420001296 PRD domain; Region: PRD; pfam00874 692420001297 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 692420001298 active site 692420001299 P-loop; other site 692420001300 phosphorylation site [posttranslational modification] 692420001301 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 692420001302 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 692420001303 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 692420001304 acyl-activating enzyme (AAE) consensus motif; other site 692420001305 putative AMP binding site [chemical binding]; other site 692420001306 putative active site [active] 692420001307 putative CoA binding site [chemical binding]; other site 692420001308 short chain dehydrogenase; Provisional; Region: PRK06701 692420001309 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 692420001310 NAD binding site [chemical binding]; other site 692420001311 metal binding site [ion binding]; metal-binding site 692420001312 active site 692420001313 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 692420001314 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 692420001315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 692420001316 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 692420001317 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 692420001318 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 692420001319 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 692420001320 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 692420001321 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 692420001322 putative DNA binding site [nucleotide binding]; other site 692420001323 putative Zn2+ binding site [ion binding]; other site 692420001324 AsnC family; Region: AsnC_trans_reg; pfam01037 692420001325 DNA topoisomerase III; Provisional; Region: PRK07726 692420001326 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 692420001327 active site 692420001328 putative interdomain interaction site [polypeptide binding]; other site 692420001329 putative metal-binding site [ion binding]; other site 692420001330 putative nucleotide binding site [chemical binding]; other site 692420001331 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 692420001332 domain I; other site 692420001333 DNA binding groove [nucleotide binding] 692420001334 phosphate binding site [ion binding]; other site 692420001335 domain II; other site 692420001336 domain III; other site 692420001337 nucleotide binding site [chemical binding]; other site 692420001338 catalytic site [active] 692420001339 domain IV; other site 692420001340 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 692420001341 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 692420001342 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 692420001343 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 692420001344 metal binding site [ion binding]; metal-binding site 692420001345 active site 692420001346 I-site; other site 692420001347 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 692420001348 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 692420001349 NodB motif; other site 692420001350 putative active site [active] 692420001351 putative catalytic site [active] 692420001352 putative Zn binding site [ion binding]; other site 692420001353 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 692420001354 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 692420001355 DXD motif; other site 692420001356 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 692420001357 Amino acid permease; Region: AA_permease_2; pfam13520 692420001358 pyruvate oxidase; Provisional; Region: PRK08611 692420001359 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 692420001360 PYR/PP interface [polypeptide binding]; other site 692420001361 dimer interface [polypeptide binding]; other site 692420001362 tetramer interface [polypeptide binding]; other site 692420001363 TPP binding site [chemical binding]; other site 692420001364 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 692420001365 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 692420001366 TPP-binding site [chemical binding]; other site 692420001367 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 692420001368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420001369 Coenzyme A binding pocket [chemical binding]; other site 692420001370 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420001371 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 692420001372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420001373 binding surface 692420001374 TPR motif; other site 692420001375 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420001376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420001377 TPR motif; other site 692420001378 binding surface 692420001379 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420001380 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420001381 manganese transport protein MntH; Reviewed; Region: PRK00701 692420001382 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 692420001383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 692420001384 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 692420001385 EcsC protein family; Region: EcsC; pfam12787 692420001386 General stress protein [General function prediction only]; Region: GsiB; COG3729 692420001387 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 692420001388 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 692420001389 dimanganese center [ion binding]; other site 692420001390 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 692420001391 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 692420001392 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 692420001393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420001394 putative active site [active] 692420001395 heme pocket [chemical binding]; other site 692420001396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420001397 ATP binding site [chemical binding]; other site 692420001398 Mg2+ binding site [ion binding]; other site 692420001399 G-X-G motif; other site 692420001400 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 692420001401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420001402 active site 692420001403 phosphorylation site [posttranslational modification] 692420001404 intermolecular recognition site; other site 692420001405 dimerization interface [polypeptide binding]; other site 692420001406 HTH domain; Region: HTH_11; pfam08279 692420001407 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 692420001408 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 692420001409 Domain of unknown function DUF20; Region: UPF0118; pfam01594 692420001410 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 692420001411 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420001412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420001413 Walker A/P-loop; other site 692420001414 ATP binding site [chemical binding]; other site 692420001415 Q-loop/lid; other site 692420001416 ABC transporter signature motif; other site 692420001417 Walker B; other site 692420001418 D-loop; other site 692420001419 H-loop/switch region; other site 692420001420 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 692420001421 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 692420001422 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 692420001423 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 692420001424 active site 692420001425 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 692420001426 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 692420001427 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 692420001428 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 692420001429 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 692420001430 catalytic residues [active] 692420001431 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 692420001432 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 692420001433 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 692420001434 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 692420001435 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 692420001436 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 692420001437 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 692420001438 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 692420001439 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 692420001440 ATP binding site [chemical binding]; other site 692420001441 Mg++ binding site [ion binding]; other site 692420001442 motif III; other site 692420001443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420001444 nucleotide binding region [chemical binding]; other site 692420001445 ATP-binding site [chemical binding]; other site 692420001446 Uncharacterized conserved protein [Function unknown]; Region: COG3402 692420001447 Predicted membrane protein [Function unknown]; Region: COG3428 692420001448 Bacterial PH domain; Region: DUF304; pfam03703 692420001449 Bacterial PH domain; Region: DUF304; pfam03703 692420001450 Bacterial PH domain; Region: DUF304; pfam03703 692420001451 Rhomboid family; Region: Rhomboid; pfam01694 692420001452 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 692420001453 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 692420001454 alanine racemase; Region: alr; TIGR00492 692420001455 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 692420001456 active site 692420001457 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 692420001458 dimer interface [polypeptide binding]; other site 692420001459 substrate binding site [chemical binding]; other site 692420001460 catalytic residues [active] 692420001461 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 692420001462 ribbon-helix-helix domain containing protein; Region: PHA00617 692420001463 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 692420001464 Rsbr N terminal; Region: Rsbr_N; pfam08678 692420001465 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420001466 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420001467 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 692420001468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420001469 ATP binding site [chemical binding]; other site 692420001470 Mg2+ binding site [ion binding]; other site 692420001471 G-X-G motif; other site 692420001472 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 692420001473 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 692420001474 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 692420001475 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 692420001476 anti sigma factor interaction site; other site 692420001477 regulatory phosphorylation site [posttranslational modification]; other site 692420001478 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 692420001479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420001480 ATP binding site [chemical binding]; other site 692420001481 Mg2+ binding site [ion binding]; other site 692420001482 G-X-G motif; other site 692420001483 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 692420001484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420001485 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 692420001486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420001487 DNA binding residues [nucleotide binding] 692420001488 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 692420001489 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 692420001490 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 692420001491 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 692420001492 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 692420001493 RNA binding site [nucleotide binding]; other site 692420001494 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 692420001495 hypothetical protein; Provisional; Region: PRK04351 692420001496 Predicted transcriptional regulator [Transcription]; Region: COG1959 692420001497 Transcriptional regulator; Region: Rrf2; pfam02082 692420001498 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 692420001499 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 692420001500 DNA-binding site [nucleotide binding]; DNA binding site 692420001501 RNA-binding motif; other site 692420001502 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 692420001503 aspartate racemase; Region: asp_race; TIGR00035 692420001504 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 692420001505 Predicted transcriptional regulators [Transcription]; Region: COG1695 692420001506 Transcriptional regulator PadR-like family; Region: PadR; cl17335 692420001507 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 692420001508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001509 DNA-binding site [nucleotide binding]; DNA binding site 692420001510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420001511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420001512 homodimer interface [polypeptide binding]; other site 692420001513 catalytic residue [active] 692420001514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001515 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420001516 putative substrate translocation pore; other site 692420001517 potential frameshift: common BLAST hit: gi|16080506|ref|NP_391333.1| spore coat protein assembly factor CotR 692420001518 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 692420001519 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 692420001520 active site 692420001521 nucleophile elbow; other site 692420001522 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 692420001523 FAD binding domain; Region: FAD_binding_4; pfam01565 692420001524 Berberine and berberine like; Region: BBE; pfam08031 692420001525 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420001526 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 692420001527 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 692420001528 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 692420001529 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 692420001530 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 692420001531 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 692420001532 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 692420001533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420001534 Coenzyme A binding pocket [chemical binding]; other site 692420001535 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 692420001536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 692420001537 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 692420001538 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420001539 FeS/SAM binding site; other site 692420001540 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 692420001541 Sodium Bile acid symporter family; Region: SBF; cl17470 692420001542 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 692420001543 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 692420001544 putative NAD(P) binding site [chemical binding]; other site 692420001545 putative substrate binding site [chemical binding]; other site 692420001546 catalytic Zn binding site [ion binding]; other site 692420001547 structural Zn binding site [ion binding]; other site 692420001548 dimer interface [polypeptide binding]; other site 692420001549 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 692420001550 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 692420001551 DNA binding residues [nucleotide binding] 692420001552 putative dimer interface [polypeptide binding]; other site 692420001553 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 692420001554 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 692420001555 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001556 DNA-binding site [nucleotide binding]; DNA binding site 692420001557 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420001558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420001559 homodimer interface [polypeptide binding]; other site 692420001560 catalytic residue [active] 692420001561 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 692420001562 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420001563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420001565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420001566 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 692420001567 EamA-like transporter family; Region: EamA; cl17759 692420001568 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 692420001569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001570 DNA-binding site [nucleotide binding]; DNA binding site 692420001571 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420001572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420001573 homodimer interface [polypeptide binding]; other site 692420001574 catalytic residue [active] 692420001575 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 692420001576 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 692420001577 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 692420001578 NAD binding site [chemical binding]; other site 692420001579 catalytic Zn binding site [ion binding]; other site 692420001580 structural Zn binding site [ion binding]; other site 692420001581 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 692420001582 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 692420001583 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 692420001584 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 692420001585 catalytic triad [active] 692420001586 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 692420001587 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 692420001588 ABC transporter; Region: ABC_tran_2; pfam12848 692420001589 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 692420001590 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 692420001591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420001592 Coenzyme A binding pocket [chemical binding]; other site 692420001593 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420001594 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420001595 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420001596 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 692420001597 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 692420001598 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 692420001599 dimer interface [polypeptide binding]; other site 692420001600 active site 692420001601 metal binding site [ion binding]; metal-binding site 692420001602 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 692420001603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001604 putative substrate translocation pore; other site 692420001605 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 692420001606 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 692420001607 dimer interface [polypeptide binding]; other site 692420001608 active site 692420001609 Helix-turn-helix domain; Region: HTH_31; pfam13560 692420001610 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 692420001611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420001612 Coenzyme A binding pocket [chemical binding]; other site 692420001613 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 692420001614 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 692420001615 DNA binding residues [nucleotide binding] 692420001616 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 692420001617 EamA-like transporter family; Region: EamA; pfam00892 692420001618 EamA-like transporter family; Region: EamA; pfam00892 692420001619 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 692420001620 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 692420001621 nudix motif; other site 692420001622 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 692420001623 Epoxide hydrolase N terminus; Region: EHN; pfam06441 692420001624 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 692420001625 tartrate dehydrogenase; Provisional; Region: PRK08194 692420001626 Transcriptional regulators [Transcription]; Region: GntR; COG1802 692420001627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001628 DNA-binding site [nucleotide binding]; DNA binding site 692420001629 FCD domain; Region: FCD; pfam07729 692420001630 potential frameshift: common BLAST hit: gi|154685073|ref|YP_001420234.1| YdhE 692420001631 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 692420001632 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 692420001633 active site 692420001634 TDP-binding site; other site 692420001635 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 692420001636 Beta-lactamase; Region: Beta-lactamase; pfam00144 692420001637 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 692420001638 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 692420001639 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 692420001640 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420001641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001642 putative substrate translocation pore; other site 692420001643 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 692420001644 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001645 DNA-binding site [nucleotide binding]; DNA binding site 692420001646 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 692420001647 Transcriptional regulators [Transcription]; Region: FadR; COG2186 692420001648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420001649 DNA-binding site [nucleotide binding]; DNA binding site 692420001650 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 692420001651 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 692420001652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001653 putative substrate translocation pore; other site 692420001654 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 692420001655 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 692420001656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420001657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420001658 amino acid transporter; Region: 2A0306; TIGR00909 692420001659 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 692420001660 dimanganese center [ion binding]; other site 692420001661 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 692420001662 putative hydrophobic ligand binding site [chemical binding]; other site 692420001663 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 692420001664 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 692420001665 putative NADP binding site [chemical binding]; other site 692420001666 putative dimer interface [polypeptide binding]; other site 692420001667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001668 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 692420001669 putative substrate translocation pore; other site 692420001670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001671 thiamine monophosphate kinase; Provisional; Region: PRK05731 692420001672 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 692420001673 ATP binding site [chemical binding]; other site 692420001674 dimerization interface [polypeptide binding]; other site 692420001675 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 692420001676 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 692420001677 Glycoprotease family; Region: Peptidase_M22; pfam00814 692420001678 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 692420001679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420001680 Coenzyme A binding pocket [chemical binding]; other site 692420001681 UGMP family protein; Validated; Region: PRK09604 692420001682 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 692420001683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 692420001684 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 692420001685 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 692420001686 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 692420001687 ABC transporter; Region: ABC_tran_2; pfam12848 692420001688 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 692420001689 ABC transporter; Region: ABC_tran_2; pfam12848 692420001690 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 692420001691 trimer interface [polypeptide binding]; other site 692420001692 dimer interface [polypeptide binding]; other site 692420001693 putative active site [active] 692420001694 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 692420001695 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 692420001696 CoA binding domain; Region: CoA_binding; pfam02629 692420001697 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 692420001698 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 692420001699 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 692420001700 CAAX protease self-immunity; Region: Abi; pfam02517 692420001701 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 692420001702 oligomerisation interface [polypeptide binding]; other site 692420001703 mobile loop; other site 692420001704 roof hairpin; other site 692420001705 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 692420001706 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 692420001707 ring oligomerisation interface [polypeptide binding]; other site 692420001708 ATP/Mg binding site [chemical binding]; other site 692420001709 stacking interactions; other site 692420001710 hinge regions; other site 692420001711 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 692420001712 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 692420001713 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 692420001714 active site 692420001715 DNA binding site [nucleotide binding] 692420001716 Int/Topo IB signature motif; other site 692420001717 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420001718 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420001719 non-specific DNA binding site [nucleotide binding]; other site 692420001720 salt bridge; other site 692420001721 sequence-specific DNA binding site [nucleotide binding]; other site 692420001722 BRO family, N-terminal domain; Region: Bro-N; cl10591 692420001723 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 692420001724 Helix-turn-helix; Region: HTH_3; pfam01381 692420001725 non-specific DNA binding site [nucleotide binding]; other site 692420001726 salt bridge; other site 692420001727 sequence-specific DNA binding site [nucleotide binding]; other site 692420001728 Hypothetical protein Yqai; Region: Yqai; pfam09466 692420001729 potential frameshift: common BLAST hit: gi|16079682|ref|NP_390506.1| nuclease; skin element 692420001730 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 692420001731 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 692420001732 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 692420001733 Helix-turn-helix domain; Region: HTH_36; pfam13730 692420001734 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 692420001735 hypothetical protein; Provisional; Region: PRK06921 692420001736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420001737 Walker A motif; other site 692420001738 ATP binding site [chemical binding]; other site 692420001739 Walker B motif; other site 692420001740 arginine finger; other site 692420001741 YopX protein; Region: YopX; pfam09643 692420001742 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 692420001743 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 692420001744 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 692420001745 cofactor binding site; other site 692420001746 DNA binding site [nucleotide binding] 692420001747 substrate interaction site [chemical binding]; other site 692420001748 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 692420001749 dUTPase; Region: dUTPase_2; pfam08761 692420001750 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 692420001751 active site 692420001752 homodimer interface [polypeptide binding]; other site 692420001753 metal binding site [ion binding]; metal-binding site 692420001754 YopX protein; Region: YopX; cl09859 692420001755 positive control sigma-like factor; Validated; Region: PRK06930 692420001756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420001757 DNA binding residues [nucleotide binding] 692420001758 Helix-turn-helix domain; Region: HTH_17; pfam12728 692420001759 Uncharacterized conserved protein [Function unknown]; Region: COG5484 692420001760 Homeodomain-like domain; Region: HTH_23; pfam13384 692420001761 Phage terminase large subunit; Region: Terminase_3; cl12054 692420001762 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 692420001763 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 692420001764 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 692420001765 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 692420001766 transcription termination factor Rho; Provisional; Region: rho; PRK09376 692420001767 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 692420001768 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 692420001769 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 692420001770 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 692420001771 Phage major tail protein 2; Region: Phage_tail_2; cl11463 692420001772 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 692420001773 Interdomain contacts; other site 692420001774 Cytokine receptor motif; other site 692420001775 Phage protein; Region: DUF3647; pfam12363 692420001776 type III secretion protein HrpB7; Region: HrpB7; TIGR02559 692420001777 Phage-related protein [Function unknown]; Region: COG5412 692420001778 Phage tail protein; Region: Sipho_tail; pfam05709 692420001779 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 692420001780 Haemolysin XhlA; Region: XhlA; pfam10779 692420001781 holin, SPP1 family; Region: holin_SPP1; TIGR01592 692420001782 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 692420001783 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 692420001784 amidase catalytic site [active] 692420001785 Zn binding residues [ion binding]; other site 692420001786 substrate binding site [chemical binding]; other site 692420001787 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420001788 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 692420001789 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 692420001790 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 692420001791 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 692420001792 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 692420001793 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 692420001794 active site 692420001795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420001796 Walker A motif; other site 692420001797 ATP binding site [chemical binding]; other site 692420001798 Walker B motif; other site 692420001799 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420001800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420001801 binding surface 692420001802 TPR motif; other site 692420001803 TPR repeat; Region: TPR_11; pfam13414 692420001804 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 692420001805 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 692420001806 inhibitor binding site; inhibition site 692420001807 catalytic Zn binding site [ion binding]; other site 692420001808 structural Zn binding site [ion binding]; other site 692420001809 NADP binding site [chemical binding]; other site 692420001810 tetramer interface [polypeptide binding]; other site 692420001811 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 692420001812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420001813 putative substrate translocation pore; other site 692420001814 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 692420001815 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 692420001816 putative substrate binding site [chemical binding]; other site 692420001817 putative ATP binding site [chemical binding]; other site 692420001818 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 692420001819 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 692420001820 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 692420001821 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 692420001822 Repair protein; Region: Repair_PSII; pfam04536 692420001823 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 692420001824 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 692420001825 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 692420001826 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 692420001827 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 692420001828 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 692420001829 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 692420001830 catalytic triad [active] 692420001831 catalytic triad [active] 692420001832 oxyanion hole [active] 692420001833 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 692420001834 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 692420001835 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 692420001836 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420001837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420001838 DNA binding residues [nucleotide binding] 692420001839 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 692420001840 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 692420001841 putative NAD(P) binding site [chemical binding]; other site 692420001842 catalytic Zn binding site [ion binding]; other site 692420001843 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 692420001844 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 692420001845 Cold-inducible protein YdjO; Region: YdjO; pfam14169 692420001846 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 692420001847 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 692420001848 Multicopper oxidase; Region: Cu-oxidase; pfam00394 692420001849 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 692420001850 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 692420001851 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 692420001852 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 692420001853 MoxR-like ATPases [General function prediction only]; Region: COG0714 692420001854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420001855 Walker A motif; other site 692420001856 ATP binding site [chemical binding]; other site 692420001857 Walker B motif; other site 692420001858 arginine finger; other site 692420001859 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 692420001860 Protein of unknown function DUF58; Region: DUF58; pfam01882 692420001861 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 692420001862 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 692420001863 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 692420001864 GMP synthase; Reviewed; Region: guaA; PRK00074 692420001865 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 692420001866 AMP/PPi binding site [chemical binding]; other site 692420001867 candidate oxyanion hole; other site 692420001868 catalytic triad [active] 692420001869 potential glutamine specificity residues [chemical binding]; other site 692420001870 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 692420001871 ATP Binding subdomain [chemical binding]; other site 692420001872 Ligand Binding sites [chemical binding]; other site 692420001873 Dimerization subdomain; other site 692420001874 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 692420001875 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420001876 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420001877 DNA binding residues [nucleotide binding] 692420001878 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 692420001879 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 692420001880 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 692420001881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 692420001882 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 692420001883 NETI protein; Region: NETI; pfam14044 692420001884 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 692420001885 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 692420001886 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 692420001887 NAD binding site [chemical binding]; other site 692420001888 ATP-grasp domain; Region: ATP-grasp; pfam02222 692420001889 adenylosuccinate lyase; Provisional; Region: PRK07492 692420001890 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 692420001891 tetramer interface [polypeptide binding]; other site 692420001892 active site 692420001893 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 692420001894 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 692420001895 ATP binding site [chemical binding]; other site 692420001896 active site 692420001897 substrate binding site [chemical binding]; other site 692420001898 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 692420001899 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 692420001900 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 692420001901 putative active site [active] 692420001902 catalytic triad [active] 692420001903 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 692420001904 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 692420001905 dimerization interface [polypeptide binding]; other site 692420001906 ATP binding site [chemical binding]; other site 692420001907 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 692420001908 dimerization interface [polypeptide binding]; other site 692420001909 ATP binding site [chemical binding]; other site 692420001910 amidophosphoribosyltransferase; Provisional; Region: PRK07631 692420001911 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 692420001912 active site 692420001913 tetramer interface [polypeptide binding]; other site 692420001914 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420001915 active site 692420001916 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 692420001917 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 692420001918 dimerization interface [polypeptide binding]; other site 692420001919 putative ATP binding site [chemical binding]; other site 692420001920 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 692420001921 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 692420001922 active site 692420001923 substrate binding site [chemical binding]; other site 692420001924 cosubstrate binding site; other site 692420001925 catalytic site [active] 692420001926 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 692420001927 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 692420001928 purine monophosphate binding site [chemical binding]; other site 692420001929 dimer interface [polypeptide binding]; other site 692420001930 putative catalytic residues [active] 692420001931 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 692420001932 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 692420001933 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 692420001934 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 692420001935 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 692420001936 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 692420001937 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 692420001938 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420001939 putative DNA binding site [nucleotide binding]; other site 692420001940 putative Zn2+ binding site [ion binding]; other site 692420001941 AsnC family; Region: AsnC_trans_reg; pfam01037 692420001942 putative transporter; Provisional; Region: PRK11021 692420001943 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 692420001944 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 692420001945 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 692420001946 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 692420001947 active site 692420001948 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 692420001949 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 692420001950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 692420001951 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 692420001952 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 692420001953 active site 692420001954 FMN binding site [chemical binding]; other site 692420001955 substrate binding site [chemical binding]; other site 692420001956 3Fe-4S cluster binding site [ion binding]; other site 692420001957 PcrB family; Region: PcrB; pfam01884 692420001958 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 692420001959 substrate binding site [chemical binding]; other site 692420001960 putative active site [active] 692420001961 dimer interface [polypeptide binding]; other site 692420001962 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 692420001963 Part of AAA domain; Region: AAA_19; pfam13245 692420001964 Family description; Region: UvrD_C_2; pfam13538 692420001965 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 692420001966 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 692420001967 nucleotide binding pocket [chemical binding]; other site 692420001968 K-X-D-G motif; other site 692420001969 catalytic site [active] 692420001970 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 692420001971 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 692420001972 Helix-hairpin-helix motif; Region: HHH; pfam00633 692420001973 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 692420001974 Dimer interface [polypeptide binding]; other site 692420001975 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 692420001976 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 692420001977 putative dimer interface [polypeptide binding]; other site 692420001978 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 692420001979 putative dimer interface [polypeptide binding]; other site 692420001980 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 692420001981 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 692420001982 active site 692420001983 ATP binding site [chemical binding]; other site 692420001984 substrate binding site [chemical binding]; other site 692420001985 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 692420001986 MgtC family; Region: MgtC; pfam02308 692420001987 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 692420001988 Na binding site [ion binding]; other site 692420001989 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 692420001990 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 692420001991 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 692420001992 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 692420001993 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 692420001994 GatB domain; Region: GatB_Yqey; pfam02637 692420001995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420001996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420001997 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 692420001998 Protein export membrane protein; Region: SecD_SecF; cl14618 692420001999 putative lipid kinase; Reviewed; Region: PRK13337 692420002000 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 692420002001 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 692420002002 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 692420002003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420002004 S-adenosylmethionine binding site [chemical binding]; other site 692420002005 Part of AAA domain; Region: AAA_19; pfam13245 692420002006 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 692420002007 Uncharacterized conserved protein [Function unknown]; Region: COG3410 692420002008 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420002009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420002010 Walker A/P-loop; other site 692420002011 ATP binding site [chemical binding]; other site 692420002012 Q-loop/lid; other site 692420002013 ABC transporter signature motif; other site 692420002014 Walker B; other site 692420002015 D-loop; other site 692420002016 H-loop/switch region; other site 692420002017 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 692420002018 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 692420002019 similar to DNA binding protein fragment; UPF0720 protein yeeF;, Protein of unknown function DUF600, Protein of unknown function, DUF600, staph_tand_hypo: conserved hypothetical protein 692420002020 similar to DNA binding protein fragment; UPF0720 protein yeeF;, Protein of unknown function DUF600, Protein of unknown function, DUF600, staph_tand_hypo: conserved hypothetical protein 692420002021 similar to DNA binding protein fragment; UPF0720 protein yeeF;, Protein of unknown function DUF600, Protein of unknown function, DUF600, staph_tand_hypo: conserved hypothetical protein 692420002022 similar to DNA binding protein YeeF fragment; UPF0720 protein yeeF 692420002023 LXG domain of WXG superfamily; Region: LXG; pfam04740 692420002024 hypothetical protein; Provisional; Region: PRK12378 692420002025 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 692420002026 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 692420002027 CotJB protein; Region: CotJB; pfam12652 692420002028 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 692420002029 dimanganese center [ion binding]; other site 692420002030 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 692420002031 Coenzyme A binding pocket [chemical binding]; other site 692420002032 YesK-like protein; Region: YesK; pfam14150 692420002033 Predicted membrane protein [Function unknown]; Region: COG2323 692420002034 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 692420002035 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420002036 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 692420002037 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420002038 Uncharacterized small protein [Function unknown]; Region: COG5583 692420002039 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 692420002040 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 692420002041 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420002042 MarR family; Region: MarR; pfam01047 692420002043 hypothetical protein; Provisional; Region: PRK06847 692420002044 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 692420002045 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 692420002046 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 692420002047 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 692420002048 Cytochrome P450; Region: p450; pfam00067 692420002049 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 692420002050 Flavodoxin; Region: Flavodoxin_1; pfam00258 692420002051 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 692420002052 FAD binding pocket [chemical binding]; other site 692420002053 FAD binding motif [chemical binding]; other site 692420002054 catalytic residues [active] 692420002055 NAD binding pocket [chemical binding]; other site 692420002056 phosphate binding motif [ion binding]; other site 692420002057 beta-alpha-beta structure motif; other site 692420002058 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 692420002059 Sulfatase; Region: Sulfatase; pfam00884 692420002060 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 692420002061 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 692420002062 substrate binding site; other site 692420002063 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 692420002064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420002065 NAD(P) binding site [chemical binding]; other site 692420002066 active site 692420002067 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 692420002068 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 692420002069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420002070 active site 692420002071 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 692420002072 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 692420002073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002074 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420002075 putative substrate translocation pore; other site 692420002076 amino acid transporter; Region: 2A0306; TIGR00909 692420002077 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 692420002078 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 692420002079 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 692420002080 NAD(P) binding site [chemical binding]; other site 692420002081 catalytic residues [active] 692420002082 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420002083 dimer interface [polypeptide binding]; other site 692420002084 putative CheW interface [polypeptide binding]; other site 692420002085 oxidoreductase; Provisional; Region: PRK07985 692420002086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420002087 NAD(P) binding site [chemical binding]; other site 692420002088 active site 692420002089 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 692420002090 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 692420002091 putative metal binding site; other site 692420002092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420002093 binding surface 692420002094 TPR motif; other site 692420002095 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 692420002096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420002097 Walker A/P-loop; other site 692420002098 ATP binding site [chemical binding]; other site 692420002099 Q-loop/lid; other site 692420002100 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 692420002101 ABC transporter signature motif; other site 692420002102 Walker B; other site 692420002103 D-loop; other site 692420002104 ABC transporter; Region: ABC_tran_2; pfam12848 692420002105 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 692420002106 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 692420002107 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 692420002108 DNA binding residues [nucleotide binding] 692420002109 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420002110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002111 putative substrate translocation pore; other site 692420002112 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 692420002113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420002114 Walker A/P-loop; other site 692420002115 ATP binding site [chemical binding]; other site 692420002116 Q-loop/lid; other site 692420002117 ABC transporter signature motif; other site 692420002118 Walker B; other site 692420002119 D-loop; other site 692420002120 H-loop/switch region; other site 692420002121 ABC transporter; Region: ABC_tran_2; pfam12848 692420002122 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 692420002123 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 692420002124 DEAD-like helicases superfamily; Region: DEXDc; smart00487 692420002125 ATP binding site [chemical binding]; other site 692420002126 Mg++ binding site [ion binding]; other site 692420002127 motif III; other site 692420002128 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420002129 nucleotide binding region [chemical binding]; other site 692420002130 ATP-binding site [chemical binding]; other site 692420002131 potential frameshift: common BLAST hit: gi|154685223|ref|YP_001420384.1| YfmJ 692420002132 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 692420002133 Prostaglandin dehydrogenases; Region: PGDH; cd05288 692420002134 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 692420002135 Heat induced stress protein YflT; Region: YflT; pfam11181 692420002136 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 692420002137 Amb_all domain; Region: Amb_all; smart00656 692420002138 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 692420002139 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 692420002140 transmembrane helices; other site 692420002141 BclB C-terminal domain; Region: exospore_TM; TIGR03721 692420002142 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 692420002143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420002144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420002145 dimer interface [polypeptide binding]; other site 692420002146 phosphorylation site [posttranslational modification] 692420002147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420002148 ATP binding site [chemical binding]; other site 692420002149 Mg2+ binding site [ion binding]; other site 692420002150 G-X-G motif; other site 692420002151 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 692420002152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420002153 active site 692420002154 phosphorylation site [posttranslational modification] 692420002155 intermolecular recognition site; other site 692420002156 dimerization interface [polypeptide binding]; other site 692420002157 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 692420002158 Histidine kinase; Region: His_kinase; pfam06580 692420002159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420002160 ATP binding site [chemical binding]; other site 692420002161 Mg2+ binding site [ion binding]; other site 692420002162 G-X-G motif; other site 692420002163 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 692420002164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420002165 active site 692420002166 phosphorylation site [posttranslational modification] 692420002167 intermolecular recognition site; other site 692420002168 dimerization interface [polypeptide binding]; other site 692420002169 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 692420002170 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 692420002171 Collagen binding domain; Region: Collagen_bind; pfam05737 692420002172 Collagen binding domain; Region: Collagen_bind; pfam05737 692420002173 Collagen binding domain; Region: Collagen_bind; pfam05737 692420002174 Collagen binding domain; Region: Collagen_bind; pfam05737 692420002175 Cna protein B-type domain; Region: Cna_B; pfam05738 692420002176 Cna protein B-type domain; Region: Cna_B; pfam05738 692420002177 Cna protein B-type domain; Region: Cna_B; pfam05738 692420002178 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 692420002179 Cna protein B-type domain; Region: Cna_B; pfam05738 692420002180 Cna protein B-type domain; Region: Cna_B; pfam05738 692420002181 Cna protein B-type domain; Region: Cna_B; pfam05738 692420002182 Cna protein B-type domain; Region: Cna_B; pfam05738 692420002183 Cna protein B-type domain; Region: Cna_B; pfam05738 692420002184 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 692420002185 active site 692420002186 catalytic site [active] 692420002187 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 692420002188 PAS domain; Region: PAS; smart00091 692420002189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420002190 ATP binding site [chemical binding]; other site 692420002191 Mg2+ binding site [ion binding]; other site 692420002192 G-X-G motif; other site 692420002193 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 692420002194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420002195 active site 692420002196 phosphorylation site [posttranslational modification] 692420002197 intermolecular recognition site; other site 692420002198 dimerization interface [polypeptide binding]; other site 692420002199 Transcriptional regulator; Region: CitT; pfam12431 692420002200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 692420002201 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 692420002202 Citrate transporter; Region: CitMHS; pfam03600 692420002203 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 692420002204 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 692420002205 active site 692420002206 dimer interface [polypeptide binding]; other site 692420002207 Acylphosphatase; Region: Acylphosphatase; cl00551 692420002208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 692420002209 MOSC domain; Region: MOSC; pfam03473 692420002210 3-alpha domain; Region: 3-alpha; pfam03475 692420002211 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 692420002212 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 692420002213 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 692420002214 active site 692420002215 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 692420002216 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 692420002217 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420002218 active site turn [active] 692420002219 phosphorylation site [posttranslational modification] 692420002220 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 692420002221 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 692420002222 Sulfatase; Region: Sulfatase; pfam00884 692420002223 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 692420002224 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 692420002225 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 692420002226 putative dimer interface [polypeptide binding]; other site 692420002227 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420002228 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420002229 potential frameshift: common BLAST hit: gi|154685251|ref|YP_001420412.1| TreP 692420002230 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420002231 active site turn [active] 692420002232 phosphorylation site [posttranslational modification] 692420002233 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 692420002234 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 692420002235 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 692420002236 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 692420002237 Ca binding site [ion binding]; other site 692420002238 active site 692420002239 catalytic site [active] 692420002240 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 692420002241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420002242 DNA-binding site [nucleotide binding]; DNA binding site 692420002243 UTRA domain; Region: UTRA; pfam07702 692420002244 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 692420002245 dimer interface [polypeptide binding]; other site 692420002246 FMN binding site [chemical binding]; other site 692420002247 YibE/F-like protein; Region: YibE_F; pfam07907 692420002248 YibE/F-like protein; Region: YibE_F; pfam07907 692420002249 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 692420002250 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 692420002251 active site 692420002252 metal binding site [ion binding]; metal-binding site 692420002253 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 692420002254 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 692420002255 active site 692420002256 metal binding site [ion binding]; metal-binding site 692420002257 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 692420002258 intracellular protease, PfpI family; Region: PfpI; TIGR01382 692420002259 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 692420002260 proposed catalytic triad [active] 692420002261 conserved cys residue [active] 692420002262 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420002263 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420002264 DNA binding site [nucleotide binding] 692420002265 domain linker motif; other site 692420002266 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 692420002267 putative dimerization interface [polypeptide binding]; other site 692420002268 putative ligand binding site [chemical binding]; other site 692420002269 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 692420002270 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 692420002271 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 692420002272 shikimate binding site; other site 692420002273 NAD(P) binding site [chemical binding]; other site 692420002274 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 692420002275 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 692420002276 active site 692420002277 catalytic residue [active] 692420002278 dimer interface [polypeptide binding]; other site 692420002279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002280 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420002281 putative substrate translocation pore; other site 692420002282 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 692420002283 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 692420002284 Low molecular weight phosphatase family; Region: LMWPc; cd00115 692420002285 active site 692420002286 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 692420002287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420002289 putative substrate translocation pore; other site 692420002290 calcium/proton exchanger (cax); Region: cax; TIGR00378 692420002291 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 692420002292 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 692420002293 YfkD-like protein; Region: YfkD; pfam14167 692420002294 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 692420002295 Mechanosensitive ion channel; Region: MS_channel; pfam00924 692420002296 potential frameshift: common BLAST hit: gi|154685272|ref|YP_001420433.1| YfkA 692420002297 YfkB-like domain; Region: YfkB; pfam08756 692420002298 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 692420002299 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 692420002300 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 692420002301 NodB motif; other site 692420002302 active site 692420002303 catalytic site [active] 692420002304 Cd binding site [ion binding]; other site 692420002305 potential frameshift: common BLAST hit: gi|154685275|ref|YP_001420436.1| YfjR 692420002306 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 692420002307 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 692420002308 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 692420002309 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 692420002310 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 692420002311 oligomer interface [polypeptide binding]; other site 692420002312 metal binding site [ion binding]; metal-binding site 692420002313 metal binding site [ion binding]; metal-binding site 692420002314 putative Cl binding site [ion binding]; other site 692420002315 aspartate ring; other site 692420002316 basic sphincter; other site 692420002317 hydrophobic gate; other site 692420002318 periplasmic entrance; other site 692420002319 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 692420002320 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 692420002321 minor groove reading motif; other site 692420002322 helix-hairpin-helix signature motif; other site 692420002323 substrate binding pocket [chemical binding]; other site 692420002324 active site 692420002325 TRAM domain; Region: TRAM; pfam01938 692420002326 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 692420002327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420002328 S-adenosylmethionine binding site [chemical binding]; other site 692420002329 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 692420002330 active site 692420002331 catalytic residues [active] 692420002332 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 692420002333 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 692420002334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420002335 Walker A/P-loop; other site 692420002336 ATP binding site [chemical binding]; other site 692420002337 Q-loop/lid; other site 692420002338 ABC transporter signature motif; other site 692420002339 Walker B; other site 692420002340 D-loop; other site 692420002341 H-loop/switch region; other site 692420002342 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420002343 active site 692420002344 ATP binding site [chemical binding]; other site 692420002345 substrate binding site [chemical binding]; other site 692420002346 activation loop (A-loop); other site 692420002347 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 692420002348 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 692420002349 active site 692420002350 zinc binding site [ion binding]; other site 692420002351 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 692420002352 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 692420002353 FMN binding site [chemical binding]; other site 692420002354 active site 692420002355 catalytic residues [active] 692420002356 substrate binding site [chemical binding]; other site 692420002357 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 692420002358 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 692420002359 tetramer interface [polypeptide binding]; other site 692420002360 TPP-binding site [chemical binding]; other site 692420002361 heterodimer interface [polypeptide binding]; other site 692420002362 phosphorylation loop region [posttranslational modification] 692420002363 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 692420002364 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 692420002365 alpha subunit interface [polypeptide binding]; other site 692420002366 TPP binding site [chemical binding]; other site 692420002367 heterodimer interface [polypeptide binding]; other site 692420002368 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 692420002369 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 692420002370 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 692420002371 E3 interaction surface; other site 692420002372 lipoyl attachment site [posttranslational modification]; other site 692420002373 e3 binding domain; Region: E3_binding; pfam02817 692420002374 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 692420002375 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 692420002376 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420002377 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 692420002378 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 692420002379 GAF domain; Region: GAF; pfam01590 692420002380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420002381 Walker A motif; other site 692420002382 ATP binding site [chemical binding]; other site 692420002383 Walker B motif; other site 692420002384 arginine finger; other site 692420002385 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 692420002386 Small acid-soluble spore protein H family; Region: SspH; pfam08141 692420002387 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 692420002388 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 692420002389 NAD binding site [chemical binding]; other site 692420002390 sugar binding site [chemical binding]; other site 692420002391 divalent metal binding site [ion binding]; other site 692420002392 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420002393 dimer interface [polypeptide binding]; other site 692420002394 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 692420002395 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 692420002396 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 692420002397 putative active site [active] 692420002398 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 692420002399 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 692420002400 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420002401 active site turn [active] 692420002402 phosphorylation site [posttranslational modification] 692420002403 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 692420002404 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 692420002405 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420002406 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 692420002407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420002408 Walker A/P-loop; other site 692420002409 ATP binding site [chemical binding]; other site 692420002410 Q-loop/lid; other site 692420002411 ABC transporter signature motif; other site 692420002412 Walker B; other site 692420002413 D-loop; other site 692420002414 H-loop/switch region; other site 692420002415 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420002416 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 692420002417 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 692420002418 Walker A/P-loop; other site 692420002419 ATP binding site [chemical binding]; other site 692420002420 Q-loop/lid; other site 692420002421 ABC transporter signature motif; other site 692420002422 Walker B; other site 692420002423 D-loop; other site 692420002424 H-loop/switch region; other site 692420002425 Predicted membrane protein [Function unknown]; Region: COG2259 692420002426 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 692420002427 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420002428 putative metal binding site [ion binding]; other site 692420002429 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 692420002430 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420002431 active site 692420002432 potential frameshift: common BLAST hit: gi|154685298|ref|YP_001420459.1| CtaO 692420002433 similar to heme O synthase (minor enzyme) fragment; Protoheme IX farnesyltransferase 1; Heme O synthase 1; Heme B farnesyltransferase 1;, UbiA prenyltransferase 692420002434 similar to protoheme IX farnesyltransferase fragment; Protoheme IX farnesyltransferase 1; Heme O synthase 1; Heme B farnesyltransferase 1;, UbiA prenyltransferase, cyoE_ctaB: protoheme IX farnesyltransferase 692420002435 Predicted transcriptional regulators [Transcription]; Region: COG1695 692420002436 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 692420002437 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 692420002438 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 692420002439 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 692420002440 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 692420002441 Acyltransferase family; Region: Acyl_transf_3; pfam01757 692420002442 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 692420002443 RNAase interaction site [polypeptide binding]; other site 692420002444 metal-dependent hydrolase; Provisional; Region: PRK13291 692420002445 DinB superfamily; Region: DinB_2; pfam12867 692420002446 benzoate transport; Region: 2A0115; TIGR00895 692420002447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002448 putative substrate translocation pore; other site 692420002449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002450 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420002451 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420002452 putative Zn2+ binding site [ion binding]; other site 692420002453 putative DNA binding site [nucleotide binding]; other site 692420002454 Predicted integral membrane protein [Function unknown]; Region: COG0392 692420002455 Uncharacterized conserved protein [Function unknown]; Region: COG2898 692420002456 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 692420002457 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 692420002458 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 692420002459 putative FMN binding site [chemical binding]; other site 692420002460 YfhD-like protein; Region: YfhD; pfam14151 692420002461 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 692420002462 TIGR01777 family protein; Region: yfcH 692420002463 putative NAD(P) binding site [chemical binding]; other site 692420002464 putative active site [active] 692420002465 recombination regulator RecX; Provisional; Region: recX; PRK14135 692420002466 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 692420002467 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420002468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002469 putative substrate translocation pore; other site 692420002470 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 692420002471 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 692420002472 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 692420002473 WVELL protein; Region: WVELL; pfam14043 692420002474 Bacterial SH3 domain; Region: SH3_3; pfam08239 692420002475 Bacterial SH3 domain; Region: SH3_3; cl17532 692420002476 potential frameshift: common BLAST hit: gi|154685322|ref|YP_001420483.1| YfhM 692420002477 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 692420002478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 692420002479 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 692420002480 Ligand binding site; other site 692420002481 Putative Catalytic site; other site 692420002482 DXD motif; other site 692420002483 Predicted membrane protein [Function unknown]; Region: COG4485 692420002484 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 692420002485 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 692420002486 Int/Topo IB signature motif; other site 692420002487 Domain of unknown function (DUF955); Region: DUF955; pfam06114 692420002488 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420002489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420002490 non-specific DNA binding site [nucleotide binding]; other site 692420002491 salt bridge; other site 692420002492 sequence-specific DNA binding site [nucleotide binding]; other site 692420002493 Helix-turn-helix; Region: HTH_3; pfam01381 692420002494 non-specific DNA binding site [nucleotide binding]; other site 692420002495 salt bridge; other site 692420002496 sequence-specific DNA binding site [nucleotide binding]; other site 692420002497 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 692420002498 ORF6C domain; Region: ORF6C; pfam10552 692420002499 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 692420002500 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 692420002501 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 692420002502 replicative DNA helicase; Region: DnaB; TIGR00665 692420002503 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 692420002504 Walker A motif; other site 692420002505 ATP binding site [chemical binding]; other site 692420002506 Walker B motif; other site 692420002507 DNA binding loops [nucleotide binding] 692420002508 positive control sigma-like factor; Validated; Region: PRK06930 692420002509 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420002510 DNA binding residues [nucleotide binding] 692420002511 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 692420002512 YcfA-like protein; Region: YcfA; pfam07927 692420002513 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 692420002514 Phage terminase, small subunit; Region: Terminase_4; cl01525 692420002515 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 692420002516 Phage-related protein [Function unknown]; Region: COG4695; cl01923 692420002517 Phage portal protein; Region: Phage_portal; pfam04860 692420002518 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 692420002519 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 692420002520 oligomer interface [polypeptide binding]; other site 692420002521 active site residues [active] 692420002522 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 692420002523 Phage capsid family; Region: Phage_capsid; pfam05065 692420002524 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 692420002525 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 692420002526 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 692420002527 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 692420002528 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 692420002529 N-acetyl-D-glucosamine binding site [chemical binding]; other site 692420002530 catalytic residue [active] 692420002531 Phage tail protein; Region: Sipho_tail; pfam05709 692420002532 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 692420002533 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 692420002534 active site 692420002535 catalytic triad [active] 692420002536 oxyanion hole [active] 692420002537 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 692420002538 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 692420002539 dimer interface [polypeptide binding]; other site 692420002540 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 692420002541 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 692420002542 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 692420002543 holin, SPP1 family; Region: holin_SPP1; TIGR01592 692420002544 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 692420002545 amidase catalytic site [active] 692420002546 Zn binding residues [ion binding]; other site 692420002547 substrate binding site [chemical binding]; other site 692420002548 Bacterial SH3 domain; Region: SH3_3; cl17532 692420002549 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 692420002550 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 692420002551 potential frameshift: common BLAST hit: gi|52784550|ref|YP_090379.1| RapK 692420002552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420002553 binding surface 692420002554 TPR motif; other site 692420002555 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420002556 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420002557 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 692420002558 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 692420002559 minor groove reading motif; other site 692420002560 helix-hairpin-helix signature motif; other site 692420002561 substrate binding pocket [chemical binding]; other site 692420002562 active site 692420002563 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 692420002564 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 692420002565 DNA binding and oxoG recognition site [nucleotide binding] 692420002566 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 692420002567 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 692420002568 putative NAD(P) binding site [chemical binding]; other site 692420002569 active site 692420002570 YgaB-like protein; Region: YgaB; pfam14182 692420002571 hypothetical protein; Provisional; Region: PRK13662 692420002572 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420002573 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 692420002574 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 692420002575 Walker A/P-loop; other site 692420002576 ATP binding site [chemical binding]; other site 692420002577 Q-loop/lid; other site 692420002578 ABC transporter signature motif; other site 692420002579 Walker B; other site 692420002580 D-loop; other site 692420002581 H-loop/switch region; other site 692420002582 Predicted membrane protein [Function unknown]; Region: COG4129 692420002583 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 692420002584 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 692420002585 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420002586 inhibitor-cofactor binding pocket; inhibition site 692420002587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420002588 catalytic residue [active] 692420002589 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 692420002590 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 692420002591 catalytic triad [active] 692420002592 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 692420002593 metal binding site 2 [ion binding]; metal-binding site 692420002594 putative DNA binding helix; other site 692420002595 metal binding site 1 [ion binding]; metal-binding site 692420002596 dimer interface [polypeptide binding]; other site 692420002597 structural Zn2+ binding site [ion binding]; other site 692420002598 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 692420002599 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 692420002600 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 692420002601 active site 692420002602 Int/Topo IB signature motif; other site 692420002603 DNA binding site [nucleotide binding] 692420002604 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 692420002605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 692420002606 hypothetical protein; Validated; Region: PRK08116 692420002607 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 692420002608 Walker A motif; other site 692420002609 ATP binding site [chemical binding]; other site 692420002610 Walker B motif; other site 692420002611 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 692420002612 Toprim-like; Region: Toprim_2; pfam13155 692420002613 active site 692420002614 metal binding site [ion binding]; metal-binding site 692420002615 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420002616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420002617 salt bridge; other site 692420002618 non-specific DNA binding site [nucleotide binding]; other site 692420002619 sequence-specific DNA binding site [nucleotide binding]; other site 692420002620 Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: Pgi; COG0166 692420002621 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 692420002622 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 692420002623 active site 692420002624 catalytic site [active] 692420002625 substrate binding site [chemical binding]; other site 692420002626 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 692420002627 active site 692420002628 DNA binding site [nucleotide binding] 692420002629 catalytic site [active] 692420002630 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 692420002631 active site 692420002632 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 692420002633 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 692420002634 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 692420002635 group I intron endonuclease; Region: grpIintron_endo; TIGR01453 692420002636 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 692420002637 GIY-YIG motif/motif A; other site 692420002638 putative active site [active] 692420002639 catalytic site [active] 692420002640 putative metal binding site [ion binding]; other site 692420002641 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 692420002642 DNA binding site [nucleotide binding] 692420002643 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 692420002644 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 692420002645 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 692420002646 dimer interface [polypeptide binding]; other site 692420002647 putative radical transfer pathway; other site 692420002648 diiron center [ion binding]; other site 692420002649 tyrosyl radical; other site 692420002650 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 692420002651 trimer interface [polypeptide binding]; other site 692420002652 active site 692420002653 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 692420002654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 692420002655 hypothetical protein; Provisional; Region: PRK08356 692420002656 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 692420002657 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 692420002658 cofactor binding site; other site 692420002659 DNA binding site [nucleotide binding] 692420002660 substrate interaction site [chemical binding]; other site 692420002661 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 692420002662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420002663 DNA binding residues [nucleotide binding] 692420002664 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 692420002665 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 692420002666 active site 692420002667 DNA binding site [nucleotide binding] 692420002668 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420002669 salt bridge; other site 692420002670 non-specific DNA binding site [nucleotide binding]; other site 692420002671 sequence-specific DNA binding site [nucleotide binding]; other site 692420002672 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 692420002673 Int/Topo IB signature motif; other site 692420002674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 692420002675 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 692420002676 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 692420002677 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 692420002678 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 692420002679 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 692420002680 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 692420002681 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 692420002682 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 692420002683 Phage tail protein; Region: Sipho_tail; pfam05709 692420002684 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 692420002685 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 692420002686 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 692420002687 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 692420002688 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 692420002689 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 692420002690 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 692420002691 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 692420002692 amidase catalytic site [active] 692420002693 Zn binding residues [ion binding]; other site 692420002694 substrate binding site [chemical binding]; other site 692420002695 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 692420002696 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420002697 Phage holin; Region: Phage_holin_5; pfam06946 692420002698 YolD-like protein; Region: YolD; pfam08863 692420002699 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 692420002700 non-specific DNA binding site [nucleotide binding]; other site 692420002701 salt bridge; other site 692420002702 sequence-specific DNA binding site [nucleotide binding]; other site 692420002703 Helix-turn-helix domain; Region: HTH_36; pfam13730 692420002704 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 692420002705 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 692420002706 active site pocket [active] 692420002707 oxyanion hole [active] 692420002708 catalytic triad [active] 692420002709 active site nucleophile [active] 692420002710 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 692420002711 ThiC-associated domain; Region: ThiC-associated; pfam13667 692420002712 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 692420002713 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 692420002714 FAD binding domain; Region: FAD_binding_4; pfam01565 692420002715 Berberine and berberine like; Region: BBE; pfam08031 692420002716 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 692420002717 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 692420002718 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 692420002719 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 692420002720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420002721 dimer interface [polypeptide binding]; other site 692420002722 conserved gate region; other site 692420002723 putative PBP binding loops; other site 692420002724 ABC-ATPase subunit interface; other site 692420002725 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 692420002726 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 692420002727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420002728 dimer interface [polypeptide binding]; other site 692420002729 conserved gate region; other site 692420002730 putative PBP binding loops; other site 692420002731 ABC-ATPase subunit interface; other site 692420002732 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 692420002733 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 692420002734 Walker A/P-loop; other site 692420002735 ATP binding site [chemical binding]; other site 692420002736 Q-loop/lid; other site 692420002737 ABC transporter signature motif; other site 692420002738 Walker B; other site 692420002739 D-loop; other site 692420002740 H-loop/switch region; other site 692420002741 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 692420002742 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 692420002743 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 692420002744 Walker A/P-loop; other site 692420002745 ATP binding site [chemical binding]; other site 692420002746 Q-loop/lid; other site 692420002747 ABC transporter signature motif; other site 692420002748 Walker B; other site 692420002749 D-loop; other site 692420002750 H-loop/switch region; other site 692420002751 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 692420002752 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 692420002753 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 692420002754 tetramer interface [polypeptide binding]; other site 692420002755 heme binding pocket [chemical binding]; other site 692420002756 NADPH binding site [chemical binding]; other site 692420002757 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 692420002758 active site 692420002759 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 692420002760 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 692420002761 Walker A/P-loop; other site 692420002762 ATP binding site [chemical binding]; other site 692420002763 Q-loop/lid; other site 692420002764 ABC transporter signature motif; other site 692420002765 Walker B; other site 692420002766 D-loop; other site 692420002767 H-loop/switch region; other site 692420002768 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 692420002769 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420002770 substrate binding pocket [chemical binding]; other site 692420002771 membrane-bound complex binding site; other site 692420002772 hinge residues; other site 692420002773 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 692420002774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420002775 dimer interface [polypeptide binding]; other site 692420002776 conserved gate region; other site 692420002777 putative PBP binding loops; other site 692420002778 ABC-ATPase subunit interface; other site 692420002779 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 692420002780 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 692420002781 active site 692420002782 dimer interface [polypeptide binding]; other site 692420002783 non-prolyl cis peptide bond; other site 692420002784 insertion regions; other site 692420002785 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 692420002786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420002787 non-specific DNA binding site [nucleotide binding]; other site 692420002788 salt bridge; other site 692420002789 sequence-specific DNA binding site [nucleotide binding]; other site 692420002790 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 692420002791 epoxyqueuosine reductase; Region: TIGR00276 692420002792 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 692420002793 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 692420002794 Putative amidase domain; Region: Amidase_6; pfam12671 692420002795 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 692420002796 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 692420002797 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 692420002798 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 692420002799 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 692420002800 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 692420002801 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 692420002802 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 692420002803 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420002804 MarR family; Region: MarR; pfam01047 692420002805 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 692420002806 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 692420002807 carboxyltransferase (CT) interaction site; other site 692420002808 biotinylation site [posttranslational modification]; other site 692420002809 HlyD family secretion protein; Region: HlyD_3; pfam13437 692420002810 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 692420002811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002812 putative substrate translocation pore; other site 692420002813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420002814 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 692420002815 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 692420002816 Predicted transcriptional regulators [Transcription]; Region: COG1725 692420002817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420002818 DNA-binding site [nucleotide binding]; DNA binding site 692420002819 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 692420002820 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 692420002821 Walker A/P-loop; other site 692420002822 ATP binding site [chemical binding]; other site 692420002823 Q-loop/lid; other site 692420002824 ABC transporter signature motif; other site 692420002825 Walker B; other site 692420002826 D-loop; other site 692420002827 H-loop/switch region; other site 692420002828 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420002829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420002830 Walker A/P-loop; other site 692420002831 ATP binding site [chemical binding]; other site 692420002832 Q-loop/lid; other site 692420002833 ABC transporter signature motif; other site 692420002834 Walker B; other site 692420002835 D-loop; other site 692420002836 H-loop/switch region; other site 692420002837 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 692420002838 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 692420002839 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 692420002840 DNA-binding site [nucleotide binding]; DNA binding site 692420002841 RNA-binding motif; other site 692420002842 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 692420002843 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 692420002844 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 692420002845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 692420002846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 692420002847 metal binding site [ion binding]; metal-binding site 692420002848 active site 692420002849 I-site; other site 692420002850 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 692420002851 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 692420002852 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 692420002853 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 692420002854 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 692420002855 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 692420002856 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 692420002857 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 692420002858 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 692420002859 putative active site [active] 692420002860 putative metal binding site [ion binding]; other site 692420002861 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 692420002862 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 692420002863 active site 692420002864 catalytic site [active] 692420002865 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 692420002866 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 692420002867 active site 692420002868 FOG: CBS domain [General function prediction only]; Region: COG0517 692420002869 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 692420002870 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 692420002871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420002872 motif II; other site 692420002873 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 692420002874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420002875 Coenzyme A binding pocket [chemical binding]; other site 692420002876 Predicted amidohydrolase [General function prediction only]; Region: COG0388 692420002877 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 692420002878 putative active site [active] 692420002879 catalytic triad [active] 692420002880 putative dimer interface [polypeptide binding]; other site 692420002881 aminotransferase; Validated; Region: PRK07678 692420002882 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420002883 inhibitor-cofactor binding pocket; inhibition site 692420002884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420002885 catalytic residue [active] 692420002886 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 692420002887 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 692420002888 amphipathic channel; other site 692420002889 Asn-Pro-Ala signature motifs; other site 692420002890 glycerol kinase; Provisional; Region: glpK; PRK00047 692420002891 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 692420002892 N- and C-terminal domain interface [polypeptide binding]; other site 692420002893 active site 692420002894 MgATP binding site [chemical binding]; other site 692420002895 catalytic site [active] 692420002896 metal binding site [ion binding]; metal-binding site 692420002897 glycerol binding site [chemical binding]; other site 692420002898 homotetramer interface [polypeptide binding]; other site 692420002899 homodimer interface [polypeptide binding]; other site 692420002900 FBP binding site [chemical binding]; other site 692420002901 protein IIAGlc interface [polypeptide binding]; other site 692420002902 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 692420002903 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 692420002904 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 692420002905 active site 692420002906 substrate binding site [chemical binding]; other site 692420002907 metal binding site [ion binding]; metal-binding site 692420002908 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 692420002909 GAF domain; Region: GAF; pfam01590 692420002910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 692420002911 Histidine kinase; Region: HisKA_3; pfam07730 692420002912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420002913 ATP binding site [chemical binding]; other site 692420002914 Mg2+ binding site [ion binding]; other site 692420002915 G-X-G motif; other site 692420002916 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420002917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420002918 active site 692420002919 phosphorylation site [posttranslational modification] 692420002920 intermolecular recognition site; other site 692420002921 dimerization interface [polypeptide binding]; other site 692420002922 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420002923 DNA binding residues [nucleotide binding] 692420002924 dimerization interface [polypeptide binding]; other site 692420002925 Predicted flavoprotein [General function prediction only]; Region: COG0431 692420002926 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 692420002927 YhdB-like protein; Region: YhdB; pfam14148 692420002928 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 692420002929 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420002930 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420002931 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420002932 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420002933 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 692420002934 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420002935 NlpC/P60 family; Region: NLPC_P60; pfam00877 692420002936 Transcriptional regulator; Region: Rrf2; cl17282 692420002937 Rrf2 family protein; Region: rrf2_super; TIGR00738 692420002938 Conserved TM helix; Region: TM_helix; pfam05552 692420002939 Conserved TM helix; Region: TM_helix; pfam05552 692420002940 Conserved TM helix; Region: TM_helix; pfam05552 692420002941 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 692420002942 SpoVR like protein; Region: SpoVR; pfam04293 692420002943 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 692420002944 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 692420002945 dimer interface [polypeptide binding]; other site 692420002946 active site 692420002947 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420002948 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420002949 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 692420002950 NlpC/P60 family; Region: NLPC_P60; pfam00877 692420002951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420002952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 692420002953 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420002954 dimerization interface [polypeptide binding]; other site 692420002955 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 692420002956 dimer interface [polypeptide binding]; other site 692420002957 Citrate synthase; Region: Citrate_synt; pfam00285 692420002958 active site 692420002959 citrylCoA binding site [chemical binding]; other site 692420002960 oxalacetate/citrate binding site [chemical binding]; other site 692420002961 coenzyme A binding site [chemical binding]; other site 692420002962 catalytic triad [active] 692420002963 short chain dehydrogenase; Provisional; Region: PRK06701 692420002964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420002965 NAD(P) binding site [chemical binding]; other site 692420002966 active site 692420002967 amino acid transporter; Region: 2A0306; TIGR00909 692420002968 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 692420002969 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 692420002970 Na2 binding site [ion binding]; other site 692420002971 putative substrate binding site 1 [chemical binding]; other site 692420002972 Na binding site 1 [ion binding]; other site 692420002973 putative substrate binding site 2 [chemical binding]; other site 692420002974 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 692420002975 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 692420002976 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 692420002977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420002978 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420002979 DNA binding residues [nucleotide binding] 692420002980 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 692420002981 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 692420002982 putative acyl-acceptor binding pocket; other site 692420002983 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 692420002984 Domain of unknown function DUF21; Region: DUF21; pfam01595 692420002985 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 692420002986 Transporter associated domain; Region: CorC_HlyC; smart01091 692420002987 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 692420002988 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 692420002989 DNA binding residues [nucleotide binding] 692420002990 putative dimer interface [polypeptide binding]; other site 692420002991 aspartate aminotransferase; Provisional; Region: PRK06836 692420002992 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420002993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420002994 homodimer interface [polypeptide binding]; other site 692420002995 catalytic residue [active] 692420002996 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 692420002997 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 692420002998 dimer interface [polypeptide binding]; other site 692420002999 active site 692420003000 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 692420003001 Domain of unknown function DUF21; Region: DUF21; pfam01595 692420003002 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 692420003003 Transporter associated domain; Region: CorC_HlyC; smart01091 692420003004 camphor resistance protein CrcB; Provisional; Region: PRK14213 692420003005 CrcB-like protein; Region: CRCB; cl09114 692420003006 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 692420003007 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 692420003008 active site 692420003009 catalytic site [active] 692420003010 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 692420003011 Mechanosensitive ion channel; Region: MS_channel; pfam00924 692420003012 NAD-dependent deacetylase; Provisional; Region: PRK00481 692420003013 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 692420003014 NAD+ binding site [chemical binding]; other site 692420003015 substrate binding site [chemical binding]; other site 692420003016 Zn binding site [ion binding]; other site 692420003017 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 692420003018 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 692420003019 NodB motif; other site 692420003020 active site 692420003021 catalytic site [active] 692420003022 Zn binding site [ion binding]; other site 692420003023 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 692420003024 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 692420003025 homodimer interface [polypeptide binding]; other site 692420003026 substrate-cofactor binding pocket; other site 692420003027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420003028 catalytic residue [active] 692420003029 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 692420003030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420003031 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 692420003032 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 692420003033 Ligand Binding Site [chemical binding]; other site 692420003034 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420003035 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 692420003036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420003037 Walker A/P-loop; other site 692420003038 ATP binding site [chemical binding]; other site 692420003039 Q-loop/lid; other site 692420003040 ABC transporter signature motif; other site 692420003041 Walker B; other site 692420003042 D-loop; other site 692420003043 H-loop/switch region; other site 692420003044 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420003045 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 692420003046 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 692420003047 Walker A/P-loop; other site 692420003048 ATP binding site [chemical binding]; other site 692420003049 Q-loop/lid; other site 692420003050 ABC transporter signature motif; other site 692420003051 Walker B; other site 692420003052 D-loop; other site 692420003053 H-loop/switch region; other site 692420003054 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 692420003055 NADH(P)-binding; Region: NAD_binding_10; pfam13460 692420003056 NAD binding site [chemical binding]; other site 692420003057 substrate binding site [chemical binding]; other site 692420003058 putative active site [active] 692420003059 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 692420003060 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 692420003061 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 692420003062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 692420003063 hypothetical protein; Provisional; Region: PRK13676 692420003064 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 692420003065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420003066 active site 692420003067 motif I; other site 692420003068 motif II; other site 692420003069 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 692420003070 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 692420003071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420003072 FeS/SAM binding site; other site 692420003073 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 692420003074 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 692420003075 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 692420003076 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 692420003077 TrkA-C domain; Region: TrkA_C; pfam02080 692420003078 enoyl-CoA hydratase; Provisional; Region: PRK07659 692420003079 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420003080 substrate binding site [chemical binding]; other site 692420003081 oxyanion hole (OAH) forming residues; other site 692420003082 trimer interface [polypeptide binding]; other site 692420003083 YhzD-like protein; Region: YhzD; pfam14120 692420003084 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 692420003085 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 692420003086 Walker A/P-loop; other site 692420003087 ATP binding site [chemical binding]; other site 692420003088 Q-loop/lid; other site 692420003089 ABC transporter signature motif; other site 692420003090 Walker B; other site 692420003091 D-loop; other site 692420003092 H-loop/switch region; other site 692420003093 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 692420003094 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 692420003095 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 692420003096 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 692420003097 active site 692420003098 metal binding site [ion binding]; metal-binding site 692420003099 DNA binding site [nucleotide binding] 692420003100 Uncharacterized conserved protein [Function unknown]; Region: COG4717 692420003101 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 692420003102 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 692420003103 generic binding surface II; other site 692420003104 generic binding surface I; other site 692420003105 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 692420003106 Zn2+ binding site [ion binding]; other site 692420003107 Mg2+ binding site [ion binding]; other site 692420003108 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 692420003109 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 692420003110 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 692420003111 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 692420003112 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 692420003113 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 692420003114 transcriptional regulator Hpr; Provisional; Region: PRK13777 692420003115 MarR family; Region: MarR; pfam01047 692420003116 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 692420003117 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 692420003118 homodimer interface [polypeptide binding]; other site 692420003119 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 692420003120 substrate-cofactor binding pocket; other site 692420003121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420003122 catalytic residue [active] 692420003123 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 692420003124 HIT family signature motif; other site 692420003125 catalytic residue [active] 692420003126 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 692420003127 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 692420003128 Walker A/P-loop; other site 692420003129 ATP binding site [chemical binding]; other site 692420003130 Q-loop/lid; other site 692420003131 ABC transporter signature motif; other site 692420003132 Walker B; other site 692420003133 D-loop; other site 692420003134 H-loop/switch region; other site 692420003135 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 692420003136 EcsC protein family; Region: EcsC; pfam12787 692420003137 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 692420003138 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 692420003139 metal binding site [ion binding]; metal-binding site 692420003140 dimer interface [polypeptide binding]; other site 692420003141 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 692420003142 Transglycosylase; Region: Transgly; pfam00912 692420003143 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 692420003144 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 692420003145 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 692420003146 substrate binding site [chemical binding]; other site 692420003147 active site 692420003148 ferrochelatase; Provisional; Region: PRK12435 692420003149 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 692420003150 C-terminal domain interface [polypeptide binding]; other site 692420003151 active site 692420003152 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 692420003153 active site 692420003154 N-terminal domain interface [polypeptide binding]; other site 692420003155 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 692420003156 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 692420003157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420003158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420003159 Predicted membrane protein [Function unknown]; Region: COG1511 692420003160 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 692420003161 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 692420003162 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 692420003163 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 692420003164 dimer interface [polypeptide binding]; other site 692420003165 active site 692420003166 CoA binding pocket [chemical binding]; other site 692420003167 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 692420003168 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 692420003169 putative oligomer interface [polypeptide binding]; other site 692420003170 putative active site [active] 692420003171 metal binding site [ion binding]; metal-binding site 692420003172 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 692420003173 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 692420003174 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 692420003175 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 692420003176 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 692420003177 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 692420003178 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 692420003179 NADH(P)-binding; Region: NAD_binding_10; pfam13460 692420003180 NAD(P) binding site [chemical binding]; other site 692420003181 putative active site [active] 692420003182 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 692420003183 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 692420003184 acyl-activating enzyme (AAE) consensus motif; other site 692420003185 putative AMP binding site [chemical binding]; other site 692420003186 putative active site [active] 692420003187 putative CoA binding site [chemical binding]; other site 692420003188 Peptidase family M48; Region: Peptidase_M48; pfam01435 692420003189 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 692420003190 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 692420003191 active site 692420003192 catalytic residues [active] 692420003193 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 692420003194 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 692420003195 siderophore binding site; other site 692420003196 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 692420003197 catalytic core [active] 692420003198 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 692420003199 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 692420003200 dimer interface [polypeptide binding]; other site 692420003201 active site 692420003202 acyl-CoA synthetase; Validated; Region: PRK07638 692420003203 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 692420003204 acyl-activating enzyme (AAE) consensus motif; other site 692420003205 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 692420003206 acyl-activating enzyme (AAE) consensus motif; other site 692420003207 active site 692420003208 AMP binding site [chemical binding]; other site 692420003209 CoA binding site [chemical binding]; other site 692420003210 BioY family; Region: BioY; pfam02632 692420003211 potential frameshift: common BLAST hit: gi|154685490|ref|YP_001420651.1| HemAT 692420003212 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 692420003213 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 692420003214 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420003215 dimer interface [polypeptide binding]; other site 692420003216 putative CheW interface [polypeptide binding]; other site 692420003217 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 692420003218 heme-binding site [chemical binding]; other site 692420003219 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 692420003220 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 692420003221 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 692420003222 [2Fe-2S] cluster binding site [ion binding]; other site 692420003223 short chain dehydrogenase; Provisional; Region: PRK06701 692420003224 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 692420003225 NAD binding site [chemical binding]; other site 692420003226 metal binding site [ion binding]; metal-binding site 692420003227 active site 692420003228 IDEAL domain; Region: IDEAL; pfam08858 692420003229 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 692420003230 Uncharacterized conserved protein [Function unknown]; Region: COG5646 692420003231 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 692420003232 Sterol carrier protein domain; Region: SCP2_2; pfam13530 692420003233 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 692420003234 putative binding site; other site 692420003235 putative dimer interface [polypeptide binding]; other site 692420003236 Excalibur calcium-binding domain; Region: Excalibur; cl05460 692420003237 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 692420003238 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 692420003239 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 692420003240 Na binding site [ion binding]; other site 692420003241 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 692420003242 Uncharacterized conserved protein [Function unknown]; Region: COG0398 692420003243 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 692420003244 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 692420003245 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 692420003246 Catalytic site [active] 692420003247 hypothetical protein; Provisional; Region: PRK08244 692420003248 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 692420003249 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420003250 MarR family; Region: MarR; pfam01047 692420003251 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 692420003252 Putative ammonia monooxygenase; Region: AmoA; pfam05145 692420003253 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 692420003254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420003255 putative substrate translocation pore; other site 692420003256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420003257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420003258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420003259 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 692420003260 Uncharacterized conserved protein [Function unknown]; Region: COG1633 692420003261 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 692420003262 dinuclear metal binding motif [ion binding]; other site 692420003263 Predicted membrane protein [Function unknown]; Region: COG2323 692420003264 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 692420003265 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 692420003266 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 692420003267 Part of AAA domain; Region: AAA_19; pfam13245 692420003268 Family description; Region: UvrD_C_2; pfam13538 692420003269 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 692420003270 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 692420003271 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 692420003272 active site 692420003273 metal binding site [ion binding]; metal-binding site 692420003274 DNA binding site [nucleotide binding] 692420003275 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 692420003276 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 692420003277 AAA domain; Region: AAA_23; pfam13476 692420003278 Walker A/P-loop; other site 692420003279 ATP binding site [chemical binding]; other site 692420003280 Q-loop/lid; other site 692420003281 ABC transporter signature motif; other site 692420003282 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 692420003283 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 692420003284 ABC transporter signature motif; other site 692420003285 Walker B; other site 692420003286 D-loop; other site 692420003287 H-loop/switch region; other site 692420003288 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 692420003289 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420003290 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 692420003291 Spore germination protein GerPC; Region: GerPC; pfam10737 692420003292 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 692420003293 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420003294 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 692420003295 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 692420003296 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 692420003297 hypothetical protein; Provisional; Region: PRK13673 692420003298 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 692420003299 active site 692420003300 catalytic triad [active] 692420003301 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 692420003302 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 692420003303 active site 692420003304 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 692420003305 dimer interface [polypeptide binding]; other site 692420003306 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 692420003307 Ligand Binding Site [chemical binding]; other site 692420003308 Molecular Tunnel; other site 692420003309 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 692420003310 substrate binding pocket [chemical binding]; other site 692420003311 substrate-Mg2+ binding site; other site 692420003312 aspartate-rich region 1; other site 692420003313 aspartate-rich region 2; other site 692420003314 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 692420003315 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 692420003316 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 692420003317 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 692420003318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420003319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420003320 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420003321 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420003322 DNA binding site [nucleotide binding] 692420003323 domain linker motif; other site 692420003324 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 692420003325 dimerization interface [polypeptide binding]; other site 692420003326 ligand binding site [chemical binding]; other site 692420003327 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 692420003328 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 692420003329 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 692420003330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 692420003331 Lysine efflux permease [General function prediction only]; Region: COG1279 692420003332 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 692420003333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420003334 DNA-binding site [nucleotide binding]; DNA binding site 692420003335 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420003336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420003337 homodimer interface [polypeptide binding]; other site 692420003338 catalytic residue [active] 692420003339 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 692420003340 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 692420003341 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 692420003342 Coenzyme A binding pocket [chemical binding]; other site 692420003343 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 692420003344 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 692420003345 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 692420003346 FAD binding site [chemical binding]; other site 692420003347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 692420003348 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 692420003349 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 692420003350 S1 domain; Region: S1_2; pfam13509 692420003351 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 692420003352 RNA binding site [nucleotide binding]; other site 692420003353 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 692420003354 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 692420003355 ligand binding site [chemical binding]; other site 692420003356 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420003357 dimerization interface [polypeptide binding]; other site 692420003358 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 692420003359 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420003360 dimer interface [polypeptide binding]; other site 692420003361 putative CheW interface [polypeptide binding]; other site 692420003362 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 692420003363 Cytochrome P450; Region: p450; cl12078 692420003364 EDD domain protein, DegV family; Region: DegV; TIGR00762 692420003365 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 692420003366 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420003367 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420003368 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420003369 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 692420003370 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 692420003371 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 692420003372 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 692420003373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420003374 motif II; other site 692420003375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420003376 esterase; Provisional; Region: PRK10566 692420003377 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 692420003378 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 692420003379 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 692420003380 active site 692420003381 metal binding site [ion binding]; metal-binding site 692420003382 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 692420003383 FAD binding domain; Region: FAD_binding_4; pfam01565 692420003384 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 692420003385 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420003386 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 692420003387 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 692420003388 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 692420003389 heterotetramer interface [polypeptide binding]; other site 692420003390 active site pocket [active] 692420003391 cleavage site 692420003392 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 692420003393 nucleotide binding site [chemical binding]; other site 692420003394 N-acetyl-L-glutamate binding site [chemical binding]; other site 692420003395 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 692420003396 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420003397 inhibitor-cofactor binding pocket; inhibition site 692420003398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420003399 catalytic residue [active] 692420003400 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 692420003401 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 692420003402 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 692420003403 catalytic site [active] 692420003404 subunit interface [polypeptide binding]; other site 692420003405 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 692420003406 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420003407 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 692420003408 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 692420003409 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420003410 ATP-grasp domain; Region: ATP-grasp_4; cl17255 692420003411 ornithine carbamoyltransferase; Provisional; Region: PRK00779 692420003412 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 692420003413 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 692420003414 YjzC-like protein; Region: YjzC; pfam14168 692420003415 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 692420003416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420003417 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 692420003418 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 692420003419 putative ligand binding site [chemical binding]; other site 692420003420 ComZ; Region: ComZ; pfam10815 692420003421 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 692420003422 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 692420003423 dimer interface [polypeptide binding]; other site 692420003424 active site 692420003425 CoA binding pocket [chemical binding]; other site 692420003426 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 692420003427 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 692420003428 dimer interface [polypeptide binding]; other site 692420003429 active site 692420003430 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 692420003431 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 692420003432 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 692420003433 Walker A/P-loop; other site 692420003434 ATP binding site [chemical binding]; other site 692420003435 Q-loop/lid; other site 692420003436 ABC transporter signature motif; other site 692420003437 Walker B; other site 692420003438 D-loop; other site 692420003439 H-loop/switch region; other site 692420003440 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 692420003441 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 692420003442 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 692420003443 Walker A/P-loop; other site 692420003444 ATP binding site [chemical binding]; other site 692420003445 Q-loop/lid; other site 692420003446 ABC transporter signature motif; other site 692420003447 Walker B; other site 692420003448 D-loop; other site 692420003449 H-loop/switch region; other site 692420003450 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 692420003451 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 692420003452 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 692420003453 peptide binding site [polypeptide binding]; other site 692420003454 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 692420003455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420003456 dimer interface [polypeptide binding]; other site 692420003457 conserved gate region; other site 692420003458 putative PBP binding loops; other site 692420003459 ABC-ATPase subunit interface; other site 692420003460 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 692420003461 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 692420003462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420003463 dimer interface [polypeptide binding]; other site 692420003464 conserved gate region; other site 692420003465 putative PBP binding loops; other site 692420003466 ABC-ATPase subunit interface; other site 692420003467 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 692420003468 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 692420003469 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 692420003470 active site 692420003471 HIGH motif; other site 692420003472 dimer interface [polypeptide binding]; other site 692420003473 KMSKS motif; other site 692420003474 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 692420003475 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 692420003476 peptide binding site [polypeptide binding]; other site 692420003477 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 692420003478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420003479 dimer interface [polypeptide binding]; other site 692420003480 conserved gate region; other site 692420003481 putative PBP binding loops; other site 692420003482 ABC-ATPase subunit interface; other site 692420003483 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 692420003484 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 692420003485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420003486 dimer interface [polypeptide binding]; other site 692420003487 conserved gate region; other site 692420003488 putative PBP binding loops; other site 692420003489 ABC-ATPase subunit interface; other site 692420003490 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 692420003491 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 692420003492 Walker A/P-loop; other site 692420003493 ATP binding site [chemical binding]; other site 692420003494 Q-loop/lid; other site 692420003495 ABC transporter signature motif; other site 692420003496 Walker B; other site 692420003497 D-loop; other site 692420003498 H-loop/switch region; other site 692420003499 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 692420003500 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 692420003501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 692420003502 Walker A/P-loop; other site 692420003503 ATP binding site [chemical binding]; other site 692420003504 Q-loop/lid; other site 692420003505 ABC transporter signature motif; other site 692420003506 Walker B; other site 692420003507 D-loop; other site 692420003508 H-loop/switch region; other site 692420003509 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 692420003510 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 692420003511 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 692420003512 Coenzyme A binding pocket [chemical binding]; other site 692420003513 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 692420003514 ArsC family; Region: ArsC; pfam03960 692420003515 putative catalytic residues [active] 692420003516 thiol/disulfide switch; other site 692420003517 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 692420003518 adaptor protein; Provisional; Region: PRK02315 692420003519 Competence protein CoiA-like family; Region: CoiA; cl11541 692420003520 oligoendopeptidase F; Region: pepF; TIGR00181 692420003521 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 692420003522 active site 692420003523 Zn binding site [ion binding]; other site 692420003524 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 692420003525 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 692420003526 catalytic residues [active] 692420003527 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 692420003528 apolar tunnel; other site 692420003529 heme binding site [chemical binding]; other site 692420003530 dimerization interface [polypeptide binding]; other site 692420003531 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 692420003532 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 692420003533 N-acetyl-D-glucosamine binding site [chemical binding]; other site 692420003534 catalytic residue [active] 692420003535 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 692420003536 putative active site [active] 692420003537 putative metal binding residues [ion binding]; other site 692420003538 signature motif; other site 692420003539 putative triphosphate binding site [ion binding]; other site 692420003540 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 692420003541 synthetase active site [active] 692420003542 NTP binding site [chemical binding]; other site 692420003543 metal binding site [ion binding]; metal-binding site 692420003544 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 692420003545 ATP-NAD kinase; Region: NAD_kinase; pfam01513 692420003546 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 692420003547 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 692420003548 active site 692420003549 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 692420003550 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 692420003551 active site 692420003552 metal binding site [ion binding]; metal-binding site 692420003553 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 692420003554 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 692420003555 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 692420003556 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 692420003557 thiamine phosphate binding site [chemical binding]; other site 692420003558 active site 692420003559 pyrophosphate binding site [ion binding]; other site 692420003560 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 692420003561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 692420003562 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 692420003563 thiS-thiF/thiG interaction site; other site 692420003564 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 692420003565 ThiS interaction site; other site 692420003566 putative active site [active] 692420003567 tetramer interface [polypeptide binding]; other site 692420003568 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 692420003569 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 692420003570 ATP binding site [chemical binding]; other site 692420003571 substrate interface [chemical binding]; other site 692420003572 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 692420003573 dimer interface [polypeptide binding]; other site 692420003574 substrate binding site [chemical binding]; other site 692420003575 ATP binding site [chemical binding]; other site 692420003576 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 692420003577 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 692420003578 NAD binding site [chemical binding]; other site 692420003579 homotetramer interface [polypeptide binding]; other site 692420003580 homodimer interface [polypeptide binding]; other site 692420003581 substrate binding site [chemical binding]; other site 692420003582 active site 692420003583 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 692420003584 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 692420003585 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 692420003586 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 692420003587 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 692420003588 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 692420003589 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 692420003590 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 692420003591 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 692420003592 Part of AAA domain; Region: AAA_19; pfam13245 692420003593 Family description; Region: UvrD_C_2; pfam13538 692420003594 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 692420003595 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 692420003596 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 692420003597 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 692420003598 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 692420003599 Walker A/P-loop; other site 692420003600 ATP binding site [chemical binding]; other site 692420003601 Q-loop/lid; other site 692420003602 ABC transporter signature motif; other site 692420003603 Walker B; other site 692420003604 D-loop; other site 692420003605 H-loop/switch region; other site 692420003606 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 692420003607 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 692420003608 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 692420003609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420003610 Coenzyme A binding pocket [chemical binding]; other site 692420003611 hypothetical protein; Provisional; Region: PRK13679 692420003612 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 692420003613 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 692420003614 Putative esterase; Region: Esterase; pfam00756 692420003615 cystathionine gamma-synthase; Reviewed; Region: PRK08247 692420003616 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 692420003617 homodimer interface [polypeptide binding]; other site 692420003618 substrate-cofactor binding pocket; other site 692420003619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420003620 catalytic residue [active] 692420003621 cystathionine beta-lyase; Provisional; Region: PRK08064 692420003622 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 692420003623 homodimer interface [polypeptide binding]; other site 692420003624 substrate-cofactor binding pocket; other site 692420003625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420003626 catalytic residue [active] 692420003627 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 692420003628 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 692420003629 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 692420003630 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 692420003631 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 692420003632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420003633 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 692420003634 Coenzyme A binding pocket [chemical binding]; other site 692420003635 potential frameshift: common BLAST hit: gi|16078957|ref|NP_389778.1| NTPase with transmembrane helices 692420003636 potential frameshift: common BLAST hit: gi|16078957|ref|NP_389778.1| NTPase with transmembrane helices 692420003637 YolD-like protein; Region: YolD; pfam08863 692420003638 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 692420003639 Y-family of DNA polymerases; Region: PolY; cl12025 692420003640 active site 692420003641 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 692420003642 YoqO-like protein; Region: YoqO; pfam14037 692420003643 potential frameshift: common BLAST hit: gi|308069421|ref|YP_003871026.1| Kelch repeat protein 692420003644 Kelch motif; Region: Kelch_1; pfam01344 692420003645 Kelch domain; Region: Kelch; smart00612 692420003646 Kelch motif; Region: Kelch_1; pfam01344 692420003647 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 692420003648 Kelch domain; Region: Kelch; smart00612 692420003649 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 692420003650 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 692420003651 Uncharacterized conserved protein [Function unknown]; Region: COG1359 692420003652 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420003653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420003654 putative substrate translocation pore; other site 692420003655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420003656 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420003657 putative Zn2+ binding site [ion binding]; other site 692420003658 putative DNA binding site [nucleotide binding]; other site 692420003659 dimerization interface [polypeptide binding]; other site 692420003660 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 692420003661 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 692420003662 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 692420003663 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 692420003664 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 692420003665 active site 692420003666 P-loop; other site 692420003667 phosphorylation site [posttranslational modification] 692420003668 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 692420003669 methionine cluster; other site 692420003670 active site 692420003671 phosphorylation site [posttranslational modification] 692420003672 metal binding site [ion binding]; metal-binding site 692420003673 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 692420003674 beta-galactosidase; Region: BGL; TIGR03356 692420003675 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 692420003676 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 692420003677 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 692420003678 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 692420003679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420003680 motif II; other site 692420003681 hypothetical protein; Provisional; Region: PRK09272 692420003682 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420003683 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420003684 putative DNA binding site [nucleotide binding]; other site 692420003685 putative Zn2+ binding site [ion binding]; other site 692420003686 MgtC family; Region: MgtC; pfam02308 692420003687 Putative motility protein; Region: YjfB_motility; pfam14070 692420003688 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 692420003689 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 692420003690 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 692420003691 catalytic loop [active] 692420003692 iron binding site [ion binding]; other site 692420003693 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 692420003694 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 692420003695 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 692420003696 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 692420003697 Formylmethanofuran dehydrogenase subunit B [Energy production and conversion]; Region: FwdB; COG1029 692420003698 [4Fe-4S] binding site [ion binding]; other site 692420003699 molybdopterin cofactor binding site; other site 692420003700 TIGR00245 family protein; Region: TIGR00245 692420003701 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 692420003702 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 692420003703 active site 692420003704 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 692420003705 glycosyltransferase, MGT family; Region: MGT; TIGR01426 692420003706 active site 692420003707 TDP-binding site; other site 692420003708 acceptor substrate-binding pocket; other site 692420003709 homodimer interface [polypeptide binding]; other site 692420003710 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 692420003711 Cytochrome P450; Region: p450; cl12078 692420003712 Uncharacterized conserved protein [Function unknown]; Region: COG2427 692420003713 potential frameshift: common BLAST hit: gi|154685660|ref|YP_001420821.1| YjgC 692420003714 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 692420003715 molybdopterin cofactor binding site; other site 692420003716 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 692420003717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420003718 Walker A/P-loop; other site 692420003719 ATP binding site [chemical binding]; other site 692420003720 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 692420003721 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 692420003722 Uncharacterized conserved protein [Function unknown]; Region: COG2427 692420003723 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 692420003724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420003725 Glucuronate isomerase; Region: UxaC; cl00829 692420003726 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 692420003727 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420003728 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420003729 DNA binding site [nucleotide binding] 692420003730 domain linker motif; other site 692420003731 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 692420003732 dimerization interface [polypeptide binding]; other site 692420003733 ligand binding site [chemical binding]; other site 692420003734 altronate oxidoreductase; Provisional; Region: PRK03643 692420003735 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 692420003736 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420003737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420003738 active site 692420003739 phosphorylation site [posttranslational modification] 692420003740 intermolecular recognition site; other site 692420003741 dimerization interface [polypeptide binding]; other site 692420003742 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420003743 DNA binding site [nucleotide binding] 692420003744 HAMP domain; Region: HAMP; pfam00672 692420003745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420003746 dimer interface [polypeptide binding]; other site 692420003747 phosphorylation site [posttranslational modification] 692420003748 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 692420003749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420003750 ATP binding site [chemical binding]; other site 692420003751 Mg2+ binding site [ion binding]; other site 692420003752 G-X-G motif; other site 692420003753 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 692420003754 DinB family; Region: DinB; cl17821 692420003755 DinB superfamily; Region: DinB_2; pfam12867 692420003756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420003757 binding surface 692420003758 TPR motif; other site 692420003759 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420003760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420003761 binding surface 692420003762 TPR motif; other site 692420003763 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 692420003764 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 692420003765 amidase catalytic site [active] 692420003766 Zn binding residues [ion binding]; other site 692420003767 substrate binding site [chemical binding]; other site 692420003768 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 692420003769 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420003770 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 692420003771 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 692420003772 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 692420003773 pentamer interface [polypeptide binding]; other site 692420003774 dodecaamer interface [polypeptide binding]; other site 692420003775 Protein of unknown function (DUF867); Region: DUF867; pfam05908 692420003776 Domain of unknown function (DUF955); Region: DUF955; pfam06114 692420003777 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420003778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420003779 non-specific DNA binding site [nucleotide binding]; other site 692420003780 salt bridge; other site 692420003781 sequence-specific DNA binding site [nucleotide binding]; other site 692420003782 hypothetical protein; Provisional; Region: PRK06921 692420003783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420003784 Walker A motif; other site 692420003785 ATP binding site [chemical binding]; other site 692420003786 Walker B motif; other site 692420003787 positive control sigma-like factor; Validated; Region: PRK06930 692420003788 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420003789 DNA binding residues [nucleotide binding] 692420003790 Phage terminase small subunit; Region: Phage_terminase; pfam10668 692420003791 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 692420003792 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 692420003793 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 692420003794 Phage capsid family; Region: Phage_capsid; pfam05065 692420003795 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 692420003796 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 692420003797 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 692420003798 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 692420003799 Phage XkdN-like protein; Region: XkdN; pfam08890 692420003800 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 692420003801 AAA ATPase domain; Region: AAA_15; pfam13175 692420003802 membrane protein P6; Region: PHA01399 692420003803 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 692420003804 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 692420003805 N-acetyl-D-glucosamine binding site [chemical binding]; other site 692420003806 catalytic residue [active] 692420003807 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 692420003808 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420003809 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 692420003810 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 692420003811 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 692420003812 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 692420003813 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 692420003814 Haemolysin XhlA; Region: XhlA; pfam10779 692420003815 Phage lysis protein, holin; Region: Phage_holin; pfam04688 692420003816 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 692420003817 amidase catalytic site [active] 692420003818 Zn binding residues [ion binding]; other site 692420003819 substrate binding site [chemical binding]; other site 692420003820 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420003821 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 692420003822 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 692420003823 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 692420003824 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 692420003825 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 692420003826 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 692420003827 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 692420003828 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 692420003829 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420003830 Zn binding site [ion binding]; other site 692420003831 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 692420003832 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420003833 Zn binding site [ion binding]; other site 692420003834 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 692420003835 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 692420003836 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 692420003837 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 692420003838 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 692420003839 Ligand binding site; other site 692420003840 Putative Catalytic site; other site 692420003841 DXD motif; other site 692420003842 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 692420003843 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 692420003844 protein binding site [polypeptide binding]; other site 692420003845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420003846 putative substrate translocation pore; other site 692420003847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420003848 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 692420003849 SxDxEG motif; other site 692420003850 active site 692420003851 metal binding site [ion binding]; metal-binding site 692420003852 homopentamer interface [polypeptide binding]; other site 692420003853 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 692420003854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420003855 dimer interface [polypeptide binding]; other site 692420003856 conserved gate region; other site 692420003857 putative PBP binding loops; other site 692420003858 ABC-ATPase subunit interface; other site 692420003859 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 692420003860 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 692420003861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420003862 dimer interface [polypeptide binding]; other site 692420003863 conserved gate region; other site 692420003864 putative PBP binding loops; other site 692420003865 ABC-ATPase subunit interface; other site 692420003866 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 692420003867 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 692420003868 Walker A/P-loop; other site 692420003869 ATP binding site [chemical binding]; other site 692420003870 Q-loop/lid; other site 692420003871 ABC transporter signature motif; other site 692420003872 Walker B; other site 692420003873 D-loop; other site 692420003874 H-loop/switch region; other site 692420003875 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 692420003876 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 692420003877 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 692420003878 peptide binding site [polypeptide binding]; other site 692420003879 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 692420003880 dimer interface [polypeptide binding]; other site 692420003881 catalytic triad [active] 692420003882 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 692420003883 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 692420003884 active site 692420003885 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 692420003886 NlpC/P60 family; Region: NLPC_P60; pfam00877 692420003887 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 692420003888 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 692420003889 Walker A/P-loop; other site 692420003890 ATP binding site [chemical binding]; other site 692420003891 Q-loop/lid; other site 692420003892 ABC transporter signature motif; other site 692420003893 Walker B; other site 692420003894 D-loop; other site 692420003895 H-loop/switch region; other site 692420003896 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 692420003897 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 692420003898 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 692420003899 Amidinotransferase; Region: Amidinotransf; pfam02274 692420003900 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 692420003901 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 692420003902 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 692420003903 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 692420003904 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 692420003905 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 692420003906 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 692420003907 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 692420003908 putative active site [active] 692420003909 putative substrate binding site [chemical binding]; other site 692420003910 putative cosubstrate binding site; other site 692420003911 catalytic site [active] 692420003912 gamma-glutamyl kinase; Provisional; Region: PRK05429 692420003913 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 692420003914 nucleotide binding site [chemical binding]; other site 692420003915 homotetrameric interface [polypeptide binding]; other site 692420003916 putative phosphate binding site [ion binding]; other site 692420003917 putative allosteric binding site; other site 692420003918 PUA domain; Region: PUA; pfam01472 692420003919 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 692420003920 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 692420003921 putative catalytic cysteine [active] 692420003922 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 692420003923 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420003924 MarR family; Region: MarR; pfam01047 692420003925 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 692420003926 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 692420003927 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 692420003928 putative metal binding site; other site 692420003929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420003930 binding surface 692420003931 TPR motif; other site 692420003932 TPR repeat; Region: TPR_11; pfam13414 692420003933 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 692420003934 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 692420003935 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 692420003936 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 692420003937 ligand binding site [chemical binding]; other site 692420003938 flexible hinge region; other site 692420003939 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 692420003940 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 692420003941 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 692420003942 THF binding site; other site 692420003943 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 692420003944 substrate binding site [chemical binding]; other site 692420003945 THF binding site; other site 692420003946 zinc-binding site [ion binding]; other site 692420003947 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 692420003948 active site 692420003949 catalytic residues [active] 692420003950 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420003951 Cobalt transport protein; Region: CbiQ; pfam02361 692420003952 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 692420003953 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 692420003954 Walker A/P-loop; other site 692420003955 ATP binding site [chemical binding]; other site 692420003956 Q-loop/lid; other site 692420003957 ABC transporter signature motif; other site 692420003958 Walker B; other site 692420003959 D-loop; other site 692420003960 H-loop/switch region; other site 692420003961 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 692420003962 Walker A/P-loop; other site 692420003963 ATP binding site [chemical binding]; other site 692420003964 Q-loop/lid; other site 692420003965 ABC transporter signature motif; other site 692420003966 Walker B; other site 692420003967 D-loop; other site 692420003968 H-loop/switch region; other site 692420003969 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 692420003970 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 692420003971 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420003972 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420003973 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 692420003974 active site 692420003975 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 692420003976 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 692420003977 MgtE intracellular N domain; Region: MgtE_N; smart00924 692420003978 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 692420003979 Divalent cation transporter; Region: MgtE; pfam01769 692420003980 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 692420003981 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 692420003982 DNA binding residues [nucleotide binding] 692420003983 putative dimer interface [polypeptide binding]; other site 692420003984 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420003985 MarR family; Region: MarR; pfam01047 692420003986 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 692420003987 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 692420003988 active site 692420003989 DNA binding site [nucleotide binding] 692420003990 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 692420003991 nucleotide binding site [chemical binding]; other site 692420003992 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 692420003993 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 692420003994 putative DNA binding site [nucleotide binding]; other site 692420003995 putative homodimer interface [polypeptide binding]; other site 692420003996 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 692420003997 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 692420003998 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 692420003999 PAS domain; Region: PAS_9; pfam13426 692420004000 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 692420004001 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 692420004002 metal binding site [ion binding]; metal-binding site 692420004003 active site 692420004004 I-site; other site 692420004005 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 692420004006 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 692420004007 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 692420004008 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 692420004009 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 692420004010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420004011 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 692420004012 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 692420004013 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 692420004014 heat shock protein HtpX; Provisional; Region: PRK05457 692420004015 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 692420004016 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 692420004017 Predicted membrane protein [Function unknown]; Region: COG2323 692420004018 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 692420004019 Acyltransferase family; Region: Acyl_transf_3; pfam01757 692420004020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420004021 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 692420004022 putative active site [active] 692420004023 heme pocket [chemical binding]; other site 692420004024 PAS domain; Region: PAS; smart00091 692420004025 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 692420004026 PAS domain; Region: PAS; smart00091 692420004027 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 692420004028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420004029 dimer interface [polypeptide binding]; other site 692420004030 phosphorylation site [posttranslational modification] 692420004031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420004032 ATP binding site [chemical binding]; other site 692420004033 Mg2+ binding site [ion binding]; other site 692420004034 G-X-G motif; other site 692420004035 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 692420004036 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 692420004037 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 692420004038 DNA binding site [nucleotide binding] 692420004039 active site 692420004040 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 692420004041 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 692420004042 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 692420004043 Phosphotransferase enzyme family; Region: APH; pfam01636 692420004044 Predicted amidohydrolase [General function prediction only]; Region: COG0388 692420004045 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 692420004046 putative active site [active] 692420004047 catalytic triad [active] 692420004048 putative dimer interface [polypeptide binding]; other site 692420004049 transaminase; Reviewed; Region: PRK08068 692420004050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420004051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420004052 homodimer interface [polypeptide binding]; other site 692420004053 catalytic residue [active] 692420004054 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 692420004055 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 692420004056 dimer interface [polypeptide binding]; other site 692420004057 active site 692420004058 catalytic residue [active] 692420004059 metal binding site [ion binding]; metal-binding site 692420004060 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 692420004061 intersubunit interface [polypeptide binding]; other site 692420004062 active site 692420004063 Zn2+ binding site [ion binding]; other site 692420004064 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 692420004065 Cupin domain; Region: Cupin_2; pfam07883 692420004066 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 692420004067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420004068 dimer interface [polypeptide binding]; other site 692420004069 phosphorylation site [posttranslational modification] 692420004070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420004071 ATP binding site [chemical binding]; other site 692420004072 Mg2+ binding site [ion binding]; other site 692420004073 G-X-G motif; other site 692420004074 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420004075 MarR family; Region: MarR; pfam01047 692420004076 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 692420004077 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 692420004078 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 692420004079 ligand binding site [chemical binding]; other site 692420004080 flagellar motor protein MotA; Validated; Region: PRK08124 692420004081 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 692420004082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420004083 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 692420004084 Walker A motif; other site 692420004085 ATP binding site [chemical binding]; other site 692420004086 Walker B motif; other site 692420004087 arginine finger; other site 692420004088 UvrB/uvrC motif; Region: UVR; pfam02151 692420004089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420004090 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 692420004091 Walker A motif; other site 692420004092 ATP binding site [chemical binding]; other site 692420004093 Walker B motif; other site 692420004094 arginine finger; other site 692420004095 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 692420004096 Uncharacterized membrane protein [Function unknown]; Region: COG3949 692420004097 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 692420004098 Ligand Binding Site [chemical binding]; other site 692420004099 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 692420004100 active site 692420004101 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 692420004102 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 692420004103 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 692420004104 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 692420004105 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 692420004106 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 692420004107 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 692420004108 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 692420004109 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 692420004110 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 692420004111 catalytic residues [active] 692420004112 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 692420004113 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 692420004114 Soluble P-type ATPase [General function prediction only]; Region: COG4087 692420004115 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 692420004116 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 692420004117 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 692420004118 active site 692420004119 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420004120 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420004121 DNA binding site [nucleotide binding] 692420004122 domain linker motif; other site 692420004123 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 692420004124 putative dimerization interface [polypeptide binding]; other site 692420004125 putative ligand binding site [chemical binding]; other site 692420004126 CAT RNA binding domain; Region: CAT_RBD; pfam03123 692420004127 transcriptional antiterminator BglG; Provisional; Region: PRK09772 692420004128 PRD domain; Region: PRD; pfam00874 692420004129 PRD domain; Region: PRD; pfam00874 692420004130 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 692420004131 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 692420004132 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420004133 active site turn [active] 692420004134 phosphorylation site [posttranslational modification] 692420004135 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 692420004136 HPr interaction site; other site 692420004137 glycerol kinase (GK) interaction site [polypeptide binding]; other site 692420004138 active site 692420004139 phosphorylation site [posttranslational modification] 692420004140 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 692420004141 dimerization domain swap beta strand [polypeptide binding]; other site 692420004142 regulatory protein interface [polypeptide binding]; other site 692420004143 active site 692420004144 regulatory phosphorylation site [posttranslational modification]; other site 692420004145 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 692420004146 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 692420004147 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 692420004148 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 692420004149 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 692420004150 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 692420004151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420004152 FeS/SAM binding site; other site 692420004153 Cache domain; Region: Cache_1; pfam02743 692420004154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420004155 dimerization interface [polypeptide binding]; other site 692420004156 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 692420004157 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420004158 dimer interface [polypeptide binding]; other site 692420004159 putative CheW interface [polypeptide binding]; other site 692420004160 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 692420004161 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 692420004162 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 692420004163 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 692420004164 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 692420004165 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420004166 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420004167 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 692420004168 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 692420004169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420004170 putative active site [active] 692420004171 heme pocket [chemical binding]; other site 692420004172 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 692420004173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420004174 putative active site [active] 692420004175 heme pocket [chemical binding]; other site 692420004176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420004177 putative active site [active] 692420004178 heme pocket [chemical binding]; other site 692420004179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420004180 dimer interface [polypeptide binding]; other site 692420004181 phosphorylation site [posttranslational modification] 692420004182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420004183 ATP binding site [chemical binding]; other site 692420004184 Mg2+ binding site [ion binding]; other site 692420004185 G-X-G motif; other site 692420004186 aminotransferase A; Validated; Region: PRK07683 692420004187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420004188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420004189 homodimer interface [polypeptide binding]; other site 692420004190 catalytic residue [active] 692420004191 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 692420004192 putative CheA interaction surface; other site 692420004193 Response regulator receiver domain; Region: Response_reg; pfam00072 692420004194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420004195 active site 692420004196 phosphorylation site [posttranslational modification] 692420004197 intermolecular recognition site; other site 692420004198 dimerization interface [polypeptide binding]; other site 692420004199 YkyB-like protein; Region: YkyB; pfam14177 692420004200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420004201 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420004202 putative substrate translocation pore; other site 692420004203 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420004204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 692420004205 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 692420004206 phosphodiesterase YaeI; Provisional; Region: PRK11340 692420004207 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 692420004208 putative active site [active] 692420004209 putative metal binding site [ion binding]; other site 692420004210 short chain dehydrogenase; Provisional; Region: PRK07677 692420004211 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 692420004212 NAD(P) binding site [chemical binding]; other site 692420004213 substrate binding site [chemical binding]; other site 692420004214 homotetramer interface [polypeptide binding]; other site 692420004215 active site 692420004216 homodimer interface [polypeptide binding]; other site 692420004217 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 692420004218 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 692420004219 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 692420004220 Protein of unknown function (DUF458); Region: DUF458; pfam04308 692420004221 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 692420004222 FOG: CBS domain [General function prediction only]; Region: COG0517 692420004223 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 692420004224 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420004225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 692420004226 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420004227 dimerization interface [polypeptide binding]; other site 692420004228 flavodoxin; Provisional; Region: PRK06703 692420004229 BNR repeat-like domain; Region: BNR_2; pfam13088 692420004230 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 692420004231 flavodoxin, short chain; Region: flav_short; TIGR01753 692420004232 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 692420004233 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 692420004234 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 692420004235 active site 692420004236 trimer interface [polypeptide binding]; other site 692420004237 substrate binding site [chemical binding]; other site 692420004238 CoA binding site [chemical binding]; other site 692420004239 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 692420004240 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 692420004241 metal binding site [ion binding]; metal-binding site 692420004242 putative dimer interface [polypeptide binding]; other site 692420004243 hypothetical protein; Provisional; Region: PRK03094 692420004244 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 692420004245 Mechanosensitive ion channel; Region: MS_channel; pfam00924 692420004246 potential frameshift: common BLAST hit: gi|154685832|ref|YP_001420993.1| YkuV 692420004247 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 692420004248 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 692420004249 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 692420004250 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 692420004251 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 692420004252 GTP binding site; other site 692420004253 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 692420004254 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 692420004255 ATP binding site [chemical binding]; other site 692420004256 substrate interface [chemical binding]; other site 692420004257 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 692420004258 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 692420004259 dimer interface [polypeptide binding]; other site 692420004260 putative functional site; other site 692420004261 putative MPT binding site; other site 692420004262 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 692420004263 Walker A motif; other site 692420004264 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 692420004265 MoaE homodimer interface [polypeptide binding]; other site 692420004266 MoaD interaction [polypeptide binding]; other site 692420004267 active site residues [active] 692420004268 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 692420004269 MoaE interaction surface [polypeptide binding]; other site 692420004270 MoeB interaction surface [polypeptide binding]; other site 692420004271 thiocarboxylated glycine; other site 692420004272 Yip1 domain; Region: Yip1; pfam04893 692420004273 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 692420004274 HlyD family secretion protein; Region: HlyD_3; pfam13437 692420004275 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 692420004276 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 692420004277 Walker A/P-loop; other site 692420004278 ATP binding site [chemical binding]; other site 692420004279 Q-loop/lid; other site 692420004280 ABC transporter signature motif; other site 692420004281 Walker B; other site 692420004282 D-loop; other site 692420004283 H-loop/switch region; other site 692420004284 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 692420004285 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 692420004286 FtsX-like permease family; Region: FtsX; pfam02687 692420004287 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 692420004288 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 692420004289 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 692420004290 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 692420004291 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 692420004292 putative substrate binding site [chemical binding]; other site 692420004293 putative ATP binding site [chemical binding]; other site 692420004294 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 692420004295 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 692420004296 active site 692420004297 phosphorylation site [posttranslational modification] 692420004298 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 692420004299 active site 692420004300 P-loop; other site 692420004301 phosphorylation site [posttranslational modification] 692420004302 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 692420004303 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 692420004304 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 692420004305 Catalytic site [active] 692420004306 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 692420004307 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 692420004308 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 692420004309 ABC transporter; Region: ABC_tran_2; pfam12848 692420004310 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 692420004311 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 692420004312 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 692420004313 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 692420004314 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 692420004315 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 692420004316 rod-share determining protein MreBH; Provisional; Region: PRK13929 692420004317 MreB and similar proteins; Region: MreB_like; cd10225 692420004318 nucleotide binding site [chemical binding]; other site 692420004319 Mg binding site [ion binding]; other site 692420004320 putative protofilament interaction site [polypeptide binding]; other site 692420004321 RodZ interaction site [polypeptide binding]; other site 692420004322 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 692420004323 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 692420004324 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 692420004325 PAS fold; Region: PAS; pfam00989 692420004326 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420004327 putative active site [active] 692420004328 heme pocket [chemical binding]; other site 692420004329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420004330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420004331 dimer interface [polypeptide binding]; other site 692420004332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420004333 ATP binding site [chemical binding]; other site 692420004334 Mg2+ binding site [ion binding]; other site 692420004335 G-X-G motif; other site 692420004336 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 692420004337 putative active site pocket [active] 692420004338 dimerization interface [polypeptide binding]; other site 692420004339 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 692420004340 putative active site pocket [active] 692420004341 dimerization interface [polypeptide binding]; other site 692420004342 putative catalytic residue [active] 692420004343 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 692420004344 TrkA-N domain; Region: TrkA_N; pfam02254 692420004345 TrkA-C domain; Region: TrkA_C; pfam02080 692420004346 adenine deaminase; Region: ade; TIGR01178 692420004347 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 692420004348 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 692420004349 active site 692420004350 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 692420004351 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 692420004352 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 692420004353 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 692420004354 hypothetical protein; Provisional; Region: PRK13667 692420004355 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 692420004356 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420004357 active site 692420004358 motif I; other site 692420004359 motif II; other site 692420004360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420004361 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 692420004362 active site 692420004363 catalytic residues [active] 692420004364 metal binding site [ion binding]; metal-binding site 692420004365 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 692420004366 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 692420004367 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 692420004368 TPP-binding site [chemical binding]; other site 692420004369 tetramer interface [polypeptide binding]; other site 692420004370 heterodimer interface [polypeptide binding]; other site 692420004371 phosphorylation loop region [posttranslational modification] 692420004372 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 692420004373 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 692420004374 alpha subunit interface [polypeptide binding]; other site 692420004375 TPP binding site [chemical binding]; other site 692420004376 heterodimer interface [polypeptide binding]; other site 692420004377 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 692420004378 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 692420004379 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 692420004380 E3 interaction surface; other site 692420004381 lipoyl attachment site [posttranslational modification]; other site 692420004382 e3 binding domain; Region: E3_binding; pfam02817 692420004383 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 692420004384 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 692420004385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 692420004386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420004387 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 692420004388 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 692420004389 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 692420004390 NodB motif; other site 692420004391 active site 692420004392 catalytic site [active] 692420004393 metal binding site [ion binding]; metal-binding site 692420004394 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 692420004395 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 692420004396 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 692420004397 homodimer interface [polypeptide binding]; other site 692420004398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420004399 catalytic residue [active] 692420004400 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 692420004401 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 692420004402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 692420004403 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 692420004404 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 692420004405 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 692420004406 active site 692420004407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420004408 Coenzyme A binding pocket [chemical binding]; other site 692420004409 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 692420004410 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 692420004411 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 692420004412 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 692420004413 active site 692420004414 Zn binding site [ion binding]; other site 692420004415 Putative zinc-finger; Region: zf-HC2; pfam13490 692420004416 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 692420004417 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 692420004418 G1 box; other site 692420004419 putative GEF interaction site [polypeptide binding]; other site 692420004420 GTP/Mg2+ binding site [chemical binding]; other site 692420004421 Switch I region; other site 692420004422 G2 box; other site 692420004423 G3 box; other site 692420004424 Switch II region; other site 692420004425 G4 box; other site 692420004426 G5 box; other site 692420004427 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 692420004428 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 692420004429 YlaH-like protein; Region: YlaH; pfam14036 692420004430 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 692420004431 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 692420004432 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 692420004433 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 692420004434 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 692420004435 putative active site [active] 692420004436 PhoH-like protein; Region: PhoH; pfam02562 692420004437 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 692420004438 glutaminase A; Region: Gln_ase; TIGR03814 692420004439 hypothetical protein; Provisional; Region: PRK13666 692420004440 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 692420004441 pyruvate carboxylase; Reviewed; Region: PRK12999 692420004442 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420004443 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 692420004444 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 692420004445 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 692420004446 active site 692420004447 catalytic residues [active] 692420004448 metal binding site [ion binding]; metal-binding site 692420004449 homodimer binding site [polypeptide binding]; other site 692420004450 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 692420004451 carboxyltransferase (CT) interaction site; other site 692420004452 biotinylation site [posttranslational modification]; other site 692420004453 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 692420004454 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 692420004455 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 692420004456 UbiA prenyltransferase family; Region: UbiA; pfam01040 692420004457 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 692420004458 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 692420004459 Cytochrome c; Region: Cytochrom_C; pfam00034 692420004460 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 692420004461 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 692420004462 D-pathway; other site 692420004463 Putative ubiquinol binding site [chemical binding]; other site 692420004464 Low-spin heme (heme b) binding site [chemical binding]; other site 692420004465 Putative water exit pathway; other site 692420004466 Binuclear center (heme o3/CuB) [ion binding]; other site 692420004467 K-pathway; other site 692420004468 Putative proton exit pathway; other site 692420004469 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 692420004470 Subunit I/III interface [polypeptide binding]; other site 692420004471 Subunit III/IV interface [polypeptide binding]; other site 692420004472 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 692420004473 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 692420004474 YugN-like family; Region: YugN; pfam08868 692420004475 FOG: CBS domain [General function prediction only]; Region: COG0517 692420004476 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 692420004477 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 692420004478 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 692420004479 Putative coat protein; Region: YlbD_coat; pfam14071 692420004480 YlbE-like protein; Region: YlbE; pfam14003 692420004481 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 692420004482 hypothetical protein; Provisional; Region: PRK02886 692420004483 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 692420004484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420004485 S-adenosylmethionine binding site [chemical binding]; other site 692420004486 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 692420004487 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 692420004488 active site 692420004489 (T/H)XGH motif; other site 692420004490 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 692420004491 Nucleoside recognition; Region: Gate; pfam07670 692420004492 Nucleoside recognition; Region: Gate; pfam07670 692420004493 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 692420004494 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 692420004495 active site 692420004496 nucleophile elbow; other site 692420004497 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 692420004498 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 692420004499 protein binding site [polypeptide binding]; other site 692420004500 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 692420004501 hypothetical protein; Provisional; Region: PRK13670 692420004502 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 692420004503 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 692420004504 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 692420004505 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 692420004506 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 692420004507 hypothetical protein; Provisional; Region: PRK13688 692420004508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420004509 Coenzyme A binding pocket [chemical binding]; other site 692420004510 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 692420004511 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 692420004512 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 692420004513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 692420004514 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 692420004515 mraZ protein; Region: TIGR00242 692420004516 MraZ protein; Region: MraZ; pfam02381 692420004517 MraZ protein; Region: MraZ; pfam02381 692420004518 MraW methylase family; Region: Methyltransf_5; pfam01795 692420004519 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 692420004520 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 692420004521 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 692420004522 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420004523 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 692420004524 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 692420004525 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 692420004526 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 692420004527 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420004528 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 692420004529 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 692420004530 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 692420004531 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 692420004532 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 692420004533 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 692420004534 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 692420004535 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 692420004536 Mg++ binding site [ion binding]; other site 692420004537 putative catalytic motif [active] 692420004538 putative substrate binding site [chemical binding]; other site 692420004539 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 692420004540 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 692420004541 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 692420004542 stage V sporulation protein E; Region: spoVE; TIGR02615 692420004543 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 692420004544 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 692420004545 active site 692420004546 homodimer interface [polypeptide binding]; other site 692420004547 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 692420004548 FAD binding domain; Region: FAD_binding_4; pfam01565 692420004549 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 692420004550 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 692420004551 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 692420004552 Cell division protein FtsQ; Region: FtsQ; pfam03799 692420004553 cell division protein FtsA; Region: ftsA; TIGR01174 692420004554 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 692420004555 nucleotide binding site [chemical binding]; other site 692420004556 Cell division protein FtsA; Region: FtsA; pfam14450 692420004557 cell division protein FtsZ; Validated; Region: PRK09330 692420004558 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 692420004559 nucleotide binding site [chemical binding]; other site 692420004560 SulA interaction site; other site 692420004561 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 692420004562 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 692420004563 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 692420004564 active site 692420004565 catalytic triad [active] 692420004566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 692420004567 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 692420004568 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 692420004569 Cna protein B-type domain; Region: Cna_B_2; pfam13715 692420004570 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 692420004571 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 692420004572 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 692420004573 sporulation sigma factor SigE; Reviewed; Region: PRK08301 692420004574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420004575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420004576 DNA binding residues [nucleotide binding] 692420004577 sporulation sigma factor SigG; Reviewed; Region: PRK08215 692420004578 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420004579 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 692420004580 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420004581 DNA binding residues [nucleotide binding] 692420004582 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 692420004583 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 692420004584 Walker A/P-loop; other site 692420004585 ATP binding site [chemical binding]; other site 692420004586 Q-loop/lid; other site 692420004587 ABC transporter signature motif; other site 692420004588 Walker B; other site 692420004589 D-loop; other site 692420004590 H-loop/switch region; other site 692420004591 acetylornithine deacetylase; Validated; Region: PRK08596 692420004592 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 692420004593 metal binding site [ion binding]; metal-binding site 692420004594 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 692420004595 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 692420004596 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 692420004597 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 692420004598 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 692420004599 catalytic residue [active] 692420004600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 692420004601 YGGT family; Region: YGGT; pfam02325 692420004602 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 692420004603 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420004604 RNA binding surface [nucleotide binding]; other site 692420004605 DivIVA protein; Region: DivIVA; pfam05103 692420004606 DivIVA domain; Region: DivI1A_domain; TIGR03544 692420004607 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 692420004608 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 692420004609 HIGH motif; other site 692420004610 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 692420004611 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 692420004612 active site 692420004613 KMSKS motif; other site 692420004614 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 692420004615 tRNA binding surface [nucleotide binding]; other site 692420004616 anticodon binding site; other site 692420004617 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 692420004618 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 692420004619 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 692420004620 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420004621 RNA binding surface [nucleotide binding]; other site 692420004622 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 692420004623 active site 692420004624 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 692420004625 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420004626 active site 692420004627 uracil-xanthine permease; Region: ncs2; TIGR00801 692420004628 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 692420004629 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 692420004630 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 692420004631 dihydroorotase; Validated; Region: pyrC; PRK09357 692420004632 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 692420004633 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 692420004634 active site 692420004635 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 692420004636 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 692420004637 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 692420004638 catalytic site [active] 692420004639 subunit interface [polypeptide binding]; other site 692420004640 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 692420004641 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420004642 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 692420004643 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 692420004644 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420004645 ATP-grasp domain; Region: ATP-grasp_4; cl17255 692420004646 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 692420004647 IMP binding site; other site 692420004648 dimer interface [polypeptide binding]; other site 692420004649 interdomain contacts; other site 692420004650 partial ornithine binding site; other site 692420004651 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 692420004652 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 692420004653 FAD binding pocket [chemical binding]; other site 692420004654 FAD binding motif [chemical binding]; other site 692420004655 phosphate binding motif [ion binding]; other site 692420004656 beta-alpha-beta structure motif; other site 692420004657 NAD binding pocket [chemical binding]; other site 692420004658 Iron coordination center [ion binding]; other site 692420004659 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 692420004660 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 692420004661 heterodimer interface [polypeptide binding]; other site 692420004662 active site 692420004663 FMN binding site [chemical binding]; other site 692420004664 homodimer interface [polypeptide binding]; other site 692420004665 substrate binding site [chemical binding]; other site 692420004666 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 692420004667 active site 692420004668 dimer interface [polypeptide binding]; other site 692420004669 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420004670 active site 692420004671 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 692420004672 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 692420004673 Active Sites [active] 692420004674 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 692420004675 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 692420004676 ATP-sulfurylase; Region: ATPS; cd00517 692420004677 active site 692420004678 HXXH motif; other site 692420004679 flexible loop; other site 692420004680 AAA domain; Region: AAA_33; pfam13671 692420004681 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 692420004682 ligand-binding site [chemical binding]; other site 692420004683 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 692420004684 diphthine synthase; Region: dph5; TIGR00522 692420004685 active site 692420004686 SAM binding site [chemical binding]; other site 692420004687 homodimer interface [polypeptide binding]; other site 692420004688 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 692420004689 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 692420004690 putative active site [active] 692420004691 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 692420004692 putative active site [active] 692420004693 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 692420004694 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 692420004695 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 692420004696 active site 692420004697 Na/Ca binding site [ion binding]; other site 692420004698 catalytic site [active] 692420004699 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 692420004700 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 692420004701 Domain of unknown function (DUF814); Region: DUF814; pfam05670 692420004702 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 692420004703 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 692420004704 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 692420004705 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 692420004706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420004707 motif II; other site 692420004708 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 692420004709 TIGR00255 family protein; Region: TIGR00255 692420004710 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 692420004711 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 692420004712 hypothetical protein; Provisional; Region: PRK04323 692420004713 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 692420004714 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 692420004715 catalytic site [active] 692420004716 G-X2-G-X-G-K; other site 692420004717 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 692420004718 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 692420004719 Flavoprotein; Region: Flavoprotein; pfam02441 692420004720 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 692420004721 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 692420004722 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420004723 ATP binding site [chemical binding]; other site 692420004724 putative Mg++ binding site [ion binding]; other site 692420004725 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420004726 nucleotide binding region [chemical binding]; other site 692420004727 ATP-binding site [chemical binding]; other site 692420004728 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 692420004729 active site 692420004730 catalytic residues [active] 692420004731 metal binding site [ion binding]; metal-binding site 692420004732 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 692420004733 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 692420004734 putative active site [active] 692420004735 substrate binding site [chemical binding]; other site 692420004736 putative cosubstrate binding site; other site 692420004737 catalytic site [active] 692420004738 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 692420004739 substrate binding site [chemical binding]; other site 692420004740 16S rRNA methyltransferase B; Provisional; Region: PRK14902 692420004741 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 692420004742 putative RNA binding site [nucleotide binding]; other site 692420004743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420004744 S-adenosylmethionine binding site [chemical binding]; other site 692420004745 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 692420004746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420004747 FeS/SAM binding site; other site 692420004748 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 692420004749 Protein phosphatase 2C; Region: PP2C; pfam00481 692420004750 active site 692420004751 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 692420004752 Catalytic domain of Protein Kinases; Region: PKc; cd00180 692420004753 active site 692420004754 ATP binding site [chemical binding]; other site 692420004755 substrate binding site [chemical binding]; other site 692420004756 activation loop (A-loop); other site 692420004757 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 692420004758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 692420004759 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 692420004760 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 692420004761 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 692420004762 GTPase RsgA; Reviewed; Region: PRK00098 692420004763 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 692420004764 RNA binding site [nucleotide binding]; other site 692420004765 homodimer interface [polypeptide binding]; other site 692420004766 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 692420004767 GTPase/Zn-binding domain interface [polypeptide binding]; other site 692420004768 GTP/Mg2+ binding site [chemical binding]; other site 692420004769 G4 box; other site 692420004770 G5 box; other site 692420004771 G1 box; other site 692420004772 Switch I region; other site 692420004773 G2 box; other site 692420004774 G3 box; other site 692420004775 Switch II region; other site 692420004776 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 692420004777 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 692420004778 substrate binding site [chemical binding]; other site 692420004779 hexamer interface [polypeptide binding]; other site 692420004780 metal binding site [ion binding]; metal-binding site 692420004781 Thiamine pyrophosphokinase; Region: TPK; cd07995 692420004782 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 692420004783 active site 692420004784 dimerization interface [polypeptide binding]; other site 692420004785 thiamine binding site [chemical binding]; other site 692420004786 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 692420004787 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 692420004788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 692420004789 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 692420004790 DAK2 domain; Region: Dak2; pfam02734 692420004791 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 692420004792 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 692420004793 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 692420004794 putative L-serine binding site [chemical binding]; other site 692420004795 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 692420004796 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 692420004797 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 692420004798 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 692420004799 generic binding surface II; other site 692420004800 ssDNA binding site; other site 692420004801 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420004802 ATP binding site [chemical binding]; other site 692420004803 putative Mg++ binding site [ion binding]; other site 692420004804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420004805 nucleotide binding region [chemical binding]; other site 692420004806 ATP-binding site [chemical binding]; other site 692420004807 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 692420004808 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 692420004809 putative phosphate acyltransferase; Provisional; Region: PRK05331 692420004810 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 692420004811 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 692420004812 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 692420004813 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 692420004814 NAD(P) binding site [chemical binding]; other site 692420004815 homotetramer interface [polypeptide binding]; other site 692420004816 homodimer interface [polypeptide binding]; other site 692420004817 active site 692420004818 acyl carrier protein; Provisional; Region: acpP; PRK00982 692420004819 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 692420004820 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 692420004821 dimerization interface [polypeptide binding]; other site 692420004822 active site 692420004823 metal binding site [ion binding]; metal-binding site 692420004824 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 692420004825 dsRNA binding site [nucleotide binding]; other site 692420004826 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 692420004827 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 692420004828 Walker A/P-loop; other site 692420004829 ATP binding site [chemical binding]; other site 692420004830 Q-loop/lid; other site 692420004831 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 692420004832 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 692420004833 ABC transporter signature motif; other site 692420004834 Walker B; other site 692420004835 D-loop; other site 692420004836 H-loop/switch region; other site 692420004837 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 692420004838 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 692420004839 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 692420004840 GTP binding site [chemical binding]; other site 692420004841 putative DNA-binding protein; Validated; Region: PRK00118 692420004842 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 692420004843 signal recognition particle protein; Provisional; Region: PRK10867 692420004844 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 692420004845 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 692420004846 P loop; other site 692420004847 GTP binding site [chemical binding]; other site 692420004848 Signal peptide binding domain; Region: SRP_SPB; pfam02978 692420004849 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 692420004850 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 692420004851 KH domain; Region: KH_4; pfam13083 692420004852 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 692420004853 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 692420004854 RimM N-terminal domain; Region: RimM; pfam01782 692420004855 PRC-barrel domain; Region: PRC; pfam05239 692420004856 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 692420004857 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 692420004858 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 692420004859 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 692420004860 GTP/Mg2+ binding site [chemical binding]; other site 692420004861 G4 box; other site 692420004862 G5 box; other site 692420004863 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 692420004864 G1 box; other site 692420004865 G1 box; other site 692420004866 GTP/Mg2+ binding site [chemical binding]; other site 692420004867 Switch I region; other site 692420004868 G2 box; other site 692420004869 G2 box; other site 692420004870 G3 box; other site 692420004871 G3 box; other site 692420004872 Switch II region; other site 692420004873 Switch II region; other site 692420004874 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 692420004875 RNA/DNA hybrid binding site [nucleotide binding]; other site 692420004876 active site 692420004877 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 692420004878 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 692420004879 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 692420004880 CoA-ligase; Region: Ligase_CoA; pfam00549 692420004881 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 692420004882 CoA binding domain; Region: CoA_binding; smart00881 692420004883 CoA-ligase; Region: Ligase_CoA; pfam00549 692420004884 DNA protecting protein DprA; Region: dprA; TIGR00732 692420004885 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 692420004886 DNA topoisomerase I; Validated; Region: PRK05582 692420004887 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 692420004888 active site 692420004889 interdomain interaction site; other site 692420004890 putative metal-binding site [ion binding]; other site 692420004891 nucleotide binding site [chemical binding]; other site 692420004892 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 692420004893 domain I; other site 692420004894 DNA binding groove [nucleotide binding] 692420004895 phosphate binding site [ion binding]; other site 692420004896 domain II; other site 692420004897 domain III; other site 692420004898 nucleotide binding site [chemical binding]; other site 692420004899 catalytic site [active] 692420004900 domain IV; other site 692420004901 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 692420004902 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 692420004903 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 692420004904 Glucose inhibited division protein A; Region: GIDA; pfam01134 692420004905 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 692420004906 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 692420004907 active site 692420004908 Int/Topo IB signature motif; other site 692420004909 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 692420004910 active site 692420004911 HslU subunit interaction site [polypeptide binding]; other site 692420004912 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 692420004913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420004914 Walker A motif; other site 692420004915 ATP binding site [chemical binding]; other site 692420004916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 692420004917 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 692420004918 transcriptional repressor CodY; Validated; Region: PRK04158 692420004919 CodY GAF-like domain; Region: CodY; pfam06018 692420004920 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 692420004921 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 692420004922 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 692420004923 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 692420004924 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 692420004925 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 692420004926 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 692420004927 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 692420004928 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 692420004929 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 692420004930 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 692420004931 flagellar motor switch protein FliG; Region: fliG; TIGR00207 692420004932 MgtE intracellular N domain; Region: MgtE_N; smart00924 692420004933 FliG C-terminal domain; Region: FliG_C; pfam01706 692420004934 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 692420004935 Flagellar assembly protein FliH; Region: FliH; pfam02108 692420004936 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 692420004937 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 692420004938 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 692420004939 Walker A motif/ATP binding site; other site 692420004940 Walker B motif; other site 692420004941 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 692420004942 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 692420004943 Uncharacterized conserved protein [Function unknown]; Region: COG3334 692420004944 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 692420004945 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 692420004946 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 692420004947 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 692420004948 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 692420004949 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 692420004950 Flagellar protein (FlbD); Region: FlbD; pfam06289 692420004951 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 692420004952 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 692420004953 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 692420004954 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 692420004955 flagellar motor switch protein; Validated; Region: PRK08119 692420004956 CheC-like family; Region: CheC; pfam04509 692420004957 CheC-like family; Region: CheC; pfam04509 692420004958 flagellar motor switch protein FliN; Region: fliN; TIGR02480 692420004959 Response regulator receiver domain; Region: Response_reg; pfam00072 692420004960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420004961 active site 692420004962 phosphorylation site [posttranslational modification] 692420004963 intermolecular recognition site; other site 692420004964 dimerization interface [polypeptide binding]; other site 692420004965 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 692420004966 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 692420004967 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 692420004968 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 692420004969 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 692420004970 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 692420004971 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 692420004972 FHIPEP family; Region: FHIPEP; pfam00771 692420004973 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 692420004974 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 692420004975 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 692420004976 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 692420004977 P-loop; other site 692420004978 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 692420004979 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 692420004980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420004981 active site 692420004982 phosphorylation site [posttranslational modification] 692420004983 intermolecular recognition site; other site 692420004984 dimerization interface [polypeptide binding]; other site 692420004985 CheB methylesterase; Region: CheB_methylest; pfam01339 692420004986 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 692420004987 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 692420004988 putative binding surface; other site 692420004989 active site 692420004990 P2 response regulator binding domain; Region: P2; pfam07194 692420004991 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 692420004992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420004993 ATP binding site [chemical binding]; other site 692420004994 Mg2+ binding site [ion binding]; other site 692420004995 G-X-G motif; other site 692420004996 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 692420004997 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 692420004998 putative CheA interaction surface; other site 692420004999 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 692420005000 CheC-like family; Region: CheC; pfam04509 692420005001 CheC-like family; Region: CheC; pfam04509 692420005002 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 692420005003 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 692420005004 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420005005 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 692420005006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420005007 DNA binding residues [nucleotide binding] 692420005008 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 692420005009 rRNA interaction site [nucleotide binding]; other site 692420005010 S8 interaction site; other site 692420005011 putative laminin-1 binding site; other site 692420005012 elongation factor Ts; Provisional; Region: tsf; PRK09377 692420005013 UBA/TS-N domain; Region: UBA; pfam00627 692420005014 Elongation factor TS; Region: EF_TS; pfam00889 692420005015 Elongation factor TS; Region: EF_TS; pfam00889 692420005016 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 692420005017 putative nucleotide binding site [chemical binding]; other site 692420005018 uridine monophosphate binding site [chemical binding]; other site 692420005019 homohexameric interface [polypeptide binding]; other site 692420005020 ribosome recycling factor; Reviewed; Region: frr; PRK00083 692420005021 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 692420005022 hinge region; other site 692420005023 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 692420005024 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 692420005025 catalytic residue [active] 692420005026 putative FPP diphosphate binding site; other site 692420005027 putative FPP binding hydrophobic cleft; other site 692420005028 dimer interface [polypeptide binding]; other site 692420005029 putative IPP diphosphate binding site; other site 692420005030 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 692420005031 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 692420005032 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 692420005033 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 692420005034 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 692420005035 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 692420005036 RIP metalloprotease RseP; Region: TIGR00054 692420005037 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 692420005038 active site 692420005039 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 692420005040 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 692420005041 protein binding site [polypeptide binding]; other site 692420005042 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 692420005043 putative substrate binding region [chemical binding]; other site 692420005044 prolyl-tRNA synthetase; Provisional; Region: PRK09194 692420005045 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 692420005046 dimer interface [polypeptide binding]; other site 692420005047 motif 1; other site 692420005048 active site 692420005049 motif 2; other site 692420005050 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 692420005051 putative deacylase active site [active] 692420005052 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 692420005053 active site 692420005054 motif 3; other site 692420005055 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 692420005056 anticodon binding site; other site 692420005057 DNA polymerase III PolC; Validated; Region: polC; PRK00448 692420005058 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 692420005059 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 692420005060 generic binding surface II; other site 692420005061 generic binding surface I; other site 692420005062 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 692420005063 active site 692420005064 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 692420005065 active site 692420005066 catalytic site [active] 692420005067 substrate binding site [chemical binding]; other site 692420005068 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 692420005069 ribosome maturation protein RimP; Reviewed; Region: PRK00092 692420005070 Sm and related proteins; Region: Sm_like; cl00259 692420005071 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 692420005072 putative oligomer interface [polypeptide binding]; other site 692420005073 putative RNA binding site [nucleotide binding]; other site 692420005074 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 692420005075 NusA N-terminal domain; Region: NusA_N; pfam08529 692420005076 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 692420005077 RNA binding site [nucleotide binding]; other site 692420005078 homodimer interface [polypeptide binding]; other site 692420005079 NusA-like KH domain; Region: KH_5; pfam13184 692420005080 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 692420005081 G-X-X-G motif; other site 692420005082 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 692420005083 putative RNA binding cleft [nucleotide binding]; other site 692420005084 hypothetical protein; Provisional; Region: PRK07714 692420005085 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 692420005086 translation initiation factor IF-2; Region: IF-2; TIGR00487 692420005087 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 692420005088 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 692420005089 G1 box; other site 692420005090 putative GEF interaction site [polypeptide binding]; other site 692420005091 GTP/Mg2+ binding site [chemical binding]; other site 692420005092 Switch I region; other site 692420005093 G2 box; other site 692420005094 G3 box; other site 692420005095 Switch II region; other site 692420005096 G4 box; other site 692420005097 G5 box; other site 692420005098 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 692420005099 Translation-initiation factor 2; Region: IF-2; pfam11987 692420005100 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 692420005101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 692420005102 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 692420005103 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 692420005104 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 692420005105 RNA binding site [nucleotide binding]; other site 692420005106 active site 692420005107 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 692420005108 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 692420005109 active site 692420005110 Riboflavin kinase; Region: Flavokinase; smart00904 692420005111 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 692420005112 16S/18S rRNA binding site [nucleotide binding]; other site 692420005113 S13e-L30e interaction site [polypeptide binding]; other site 692420005114 25S rRNA binding site [nucleotide binding]; other site 692420005115 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 692420005116 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 692420005117 RNase E interface [polypeptide binding]; other site 692420005118 trimer interface [polypeptide binding]; other site 692420005119 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 692420005120 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 692420005121 RNase E interface [polypeptide binding]; other site 692420005122 trimer interface [polypeptide binding]; other site 692420005123 active site 692420005124 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 692420005125 putative nucleic acid binding region [nucleotide binding]; other site 692420005126 G-X-X-G motif; other site 692420005127 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 692420005128 RNA binding site [nucleotide binding]; other site 692420005129 domain interface; other site 692420005130 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 692420005131 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 692420005132 NodB motif; other site 692420005133 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 692420005134 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 692420005135 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 692420005136 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 692420005137 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 692420005138 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 692420005139 NAD binding site [chemical binding]; other site 692420005140 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 692420005141 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 692420005142 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 692420005143 aspartate kinase I; Reviewed; Region: PRK08210 692420005144 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 692420005145 putative catalytic residues [active] 692420005146 putative nucleotide binding site [chemical binding]; other site 692420005147 putative aspartate binding site [chemical binding]; other site 692420005148 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 692420005149 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 692420005150 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 692420005151 dihydrodipicolinate synthase; Region: dapA; TIGR00674 692420005152 dimer interface [polypeptide binding]; other site 692420005153 active site 692420005154 catalytic residue [active] 692420005155 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 692420005156 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 692420005157 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 692420005158 Clp protease; Region: CLP_protease; pfam00574 692420005159 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 692420005160 active site 692420005161 YlzJ-like protein; Region: YlzJ; pfam14035 692420005162 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 692420005163 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 692420005164 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 692420005165 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 692420005166 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 692420005167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420005168 DNA-binding site [nucleotide binding]; DNA binding site 692420005169 UTRA domain; Region: UTRA; pfam07702 692420005170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420005171 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420005172 putative substrate translocation pore; other site 692420005173 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420005174 MarR family; Region: MarR_2; pfam12802 692420005175 MMPL family; Region: MMPL; pfam03176 692420005176 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 692420005177 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 692420005178 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 692420005179 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 692420005180 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 692420005181 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 692420005182 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 692420005183 classical (c) SDRs; Region: SDR_c; cd05233 692420005184 NAD(P) binding site [chemical binding]; other site 692420005185 active site 692420005186 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 692420005187 ACT domain; Region: ACT; pfam01842 692420005188 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 692420005189 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 692420005190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420005191 non-specific DNA binding site [nucleotide binding]; other site 692420005192 salt bridge; other site 692420005193 sequence-specific DNA binding site [nucleotide binding]; other site 692420005194 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 692420005195 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 692420005196 competence damage-inducible protein A; Provisional; Region: PRK00549 692420005197 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 692420005198 putative MPT binding site; other site 692420005199 Competence-damaged protein; Region: CinA; pfam02464 692420005200 recombinase A; Provisional; Region: recA; PRK09354 692420005201 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 692420005202 hexamer interface [polypeptide binding]; other site 692420005203 Walker A motif; other site 692420005204 ATP binding site [chemical binding]; other site 692420005205 Walker B motif; other site 692420005206 Beta-lactamase; Region: Beta-lactamase; pfam00144 692420005207 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 692420005208 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 692420005209 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 692420005210 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 692420005211 Zn2+ binding site [ion binding]; other site 692420005212 Mg2+ binding site [ion binding]; other site 692420005213 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 692420005214 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 692420005215 putative active site [active] 692420005216 metal binding site [ion binding]; metal-binding site 692420005217 homodimer binding site [polypeptide binding]; other site 692420005218 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 692420005219 Threonine dehydrogenase; Region: TDH; cd05281 692420005220 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 692420005221 structural Zn binding site [ion binding]; other site 692420005222 catalytic Zn binding site [ion binding]; other site 692420005223 tetramer interface [polypeptide binding]; other site 692420005224 NADP binding site [chemical binding]; other site 692420005225 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 692420005226 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 692420005227 substrate-cofactor binding pocket; other site 692420005228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420005229 catalytic residue [active] 692420005230 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 692420005231 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 692420005232 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420005233 FeS/SAM binding site; other site 692420005234 TRAM domain; Region: TRAM; pfam01938 692420005235 Predicted membrane protein [Function unknown]; Region: COG4550 692420005236 Outer spore coat protein E (CotE); Region: CotE; pfam10628 692420005237 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 692420005238 MutS domain I; Region: MutS_I; pfam01624 692420005239 MutS domain II; Region: MutS_II; pfam05188 692420005240 MutS domain III; Region: MutS_III; pfam05192 692420005241 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 692420005242 Walker A/P-loop; other site 692420005243 ATP binding site [chemical binding]; other site 692420005244 Q-loop/lid; other site 692420005245 ABC transporter signature motif; other site 692420005246 Walker B; other site 692420005247 D-loop; other site 692420005248 H-loop/switch region; other site 692420005249 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 692420005250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420005251 ATP binding site [chemical binding]; other site 692420005252 Mg2+ binding site [ion binding]; other site 692420005253 G-X-G motif; other site 692420005254 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 692420005255 ATP binding site [chemical binding]; other site 692420005256 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 692420005257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420005258 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 692420005259 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 692420005260 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 692420005261 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 692420005262 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 692420005263 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 692420005264 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 692420005265 FMN binding site [chemical binding]; other site 692420005266 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 692420005267 substrate binding site [chemical binding]; other site 692420005268 putative catalytic residue [active] 692420005269 acyl carrier protein; Validated; Region: PRK07117 692420005270 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 692420005271 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 692420005272 dimer interface [polypeptide binding]; other site 692420005273 active site 692420005274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420005275 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 692420005276 substrate binding site [chemical binding]; other site 692420005277 oxyanion hole (OAH) forming residues; other site 692420005278 trimer interface [polypeptide binding]; other site 692420005279 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 692420005280 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420005281 substrate binding site [chemical binding]; other site 692420005282 oxyanion hole (OAH) forming residues; other site 692420005283 trimer interface [polypeptide binding]; other site 692420005284 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 692420005285 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 692420005286 acyl-activating enzyme (AAE) consensus motif; other site 692420005287 putative AMP binding site [chemical binding]; other site 692420005288 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005289 Condensation domain; Region: Condensation; pfam00668 692420005290 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005291 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005292 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 692420005293 acyl-activating enzyme (AAE) consensus motif; other site 692420005294 AMP binding site [chemical binding]; other site 692420005295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005296 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005297 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005298 active site 692420005299 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005300 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005301 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 692420005302 putative NADP binding site [chemical binding]; other site 692420005303 active site 692420005304 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 692420005305 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 692420005306 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005307 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005308 active site 692420005309 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005310 putative NADP binding site [chemical binding]; other site 692420005311 active site 692420005312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005313 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005314 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005315 active site 692420005316 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005317 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005318 active site 692420005319 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005320 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005321 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 692420005322 putative NADP binding site [chemical binding]; other site 692420005323 active site 692420005324 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 692420005325 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005326 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005327 active site 692420005328 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 692420005329 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 692420005330 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005331 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005332 active site 692420005333 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005334 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 692420005335 putative NADP binding site [chemical binding]; other site 692420005336 active site 692420005337 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005338 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005339 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005340 active site 692420005341 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005342 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005343 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005344 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005345 active site 692420005346 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005347 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005348 putative NADP binding site [chemical binding]; other site 692420005349 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 692420005350 active site 692420005351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420005352 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 692420005353 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005354 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005355 active site 692420005356 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005357 putative NADP binding site [chemical binding]; other site 692420005358 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 692420005359 active site 692420005360 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005361 Condensation domain; Region: Condensation; pfam00668 692420005362 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005363 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005364 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420005365 acyl-activating enzyme (AAE) consensus motif; other site 692420005366 AMP binding site [chemical binding]; other site 692420005367 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005368 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005369 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005370 active site 692420005371 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005372 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005373 putative NADP binding site [chemical binding]; other site 692420005374 KR domain; Region: KR; pfam08659 692420005375 active site 692420005376 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 692420005377 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005378 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005379 active site 692420005380 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005381 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005382 putative NADP binding site [chemical binding]; other site 692420005383 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 692420005384 active site 692420005385 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 692420005386 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 692420005387 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005388 active site 692420005389 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 692420005390 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 692420005391 putative NADP binding site [chemical binding]; other site 692420005392 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 692420005393 active site 692420005394 Methyltransferase domain; Region: Methyltransf_23; pfam13489 692420005395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420005396 S-adenosylmethionine binding site [chemical binding]; other site 692420005397 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 692420005398 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005399 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005400 active site 692420005401 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 692420005402 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 692420005403 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005404 active site 692420005405 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005406 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 692420005407 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 692420005408 Cytochrome P450; Region: p450; cl12078 692420005409 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 692420005410 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 692420005411 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 692420005412 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 692420005413 active site 692420005414 catalytic triad [active] 692420005415 Protein of unknown function (DUF867); Region: DUF867; pfam05908 692420005416 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 692420005417 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 692420005418 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 692420005419 YmaF family; Region: YmaF; pfam12788 692420005420 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 692420005421 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 692420005422 bacterial Hfq-like; Region: Hfq; cd01716 692420005423 hexamer interface [polypeptide binding]; other site 692420005424 Sm1 motif; other site 692420005425 RNA binding site [nucleotide binding]; other site 692420005426 Sm2 motif; other site 692420005427 YmzC-like protein; Region: YmzC; pfam14157 692420005428 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 692420005429 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 692420005430 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 692420005431 Class I ribonucleotide reductase; Region: RNR_I; cd01679 692420005432 active site 692420005433 dimer interface [polypeptide binding]; other site 692420005434 catalytic residues [active] 692420005435 effector binding site; other site 692420005436 R2 peptide binding site; other site 692420005437 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 692420005438 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 692420005439 dimer interface [polypeptide binding]; other site 692420005440 putative radical transfer pathway; other site 692420005441 diiron center [ion binding]; other site 692420005442 tyrosyl radical; other site 692420005443 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 692420005444 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 692420005445 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 692420005446 active site 692420005447 metal binding site [ion binding]; metal-binding site 692420005448 Sporulation related domain; Region: SPOR; pfam05036 692420005449 stage V sporulation protein K; Region: spore_V_K; TIGR02881 692420005450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420005451 Walker A motif; other site 692420005452 ATP binding site [chemical binding]; other site 692420005453 Walker B motif; other site 692420005454 arginine finger; other site 692420005455 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 692420005456 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 692420005457 HflX GTPase family; Region: HflX; cd01878 692420005458 G1 box; other site 692420005459 GTP/Mg2+ binding site [chemical binding]; other site 692420005460 Switch I region; other site 692420005461 G2 box; other site 692420005462 G3 box; other site 692420005463 Switch II region; other site 692420005464 G4 box; other site 692420005465 G5 box; other site 692420005466 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 692420005467 Aluminium resistance protein; Region: Alum_res; pfam06838 692420005468 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 692420005469 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 692420005470 DNA binding residues [nucleotide binding] 692420005471 putative dimer interface [polypeptide binding]; other site 692420005472 glutamine synthetase, type I; Region: GlnA; TIGR00653 692420005473 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 692420005474 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 692420005475 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 692420005476 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 692420005477 Int/Topo IB signature motif; other site 692420005478 Staphylococcal nuclease homologues; Region: SNc; smart00318 692420005479 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 692420005480 Catalytic site; other site 692420005481 Excalibur calcium-binding domain; Region: Excalibur; smart00894 692420005482 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 692420005483 Uncharacterized conserved protein [Function unknown]; Region: COG5444 692420005484 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 692420005485 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 692420005486 sporulation protein YunB; Region: spo_yunB; TIGR02832 692420005487 YolD-like protein; Region: YolD; pfam08863 692420005488 DNA polymerase IV; Reviewed; Region: PRK03103 692420005489 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 692420005490 active site 692420005491 DNA binding site [nucleotide binding] 692420005492 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 692420005493 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 692420005494 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 692420005495 ATP binding site [chemical binding]; other site 692420005496 substrate interface [chemical binding]; other site 692420005497 tellurite resistance protein TehB; Provisional; Region: PRK11207 692420005498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420005499 S-adenosylmethionine binding site [chemical binding]; other site 692420005500 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 692420005501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420005502 S-adenosylmethionine binding site [chemical binding]; other site 692420005503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420005504 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420005505 putative substrate translocation pore; other site 692420005506 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 692420005507 N- and C-terminal domain interface [polypeptide binding]; other site 692420005508 active site 692420005509 MgATP binding site [chemical binding]; other site 692420005510 homodimer interface [polypeptide binding]; other site 692420005511 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 692420005512 phosphoenolpyruvate synthase; Validated; Region: PRK06241 692420005513 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 692420005514 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 692420005515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420005516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420005517 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 692420005518 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 692420005519 putative NAD(P) binding site [chemical binding]; other site 692420005520 catalytic Zn binding site [ion binding]; other site 692420005521 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420005522 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 692420005523 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 692420005524 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 692420005525 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 692420005526 catalytic residues [active] 692420005527 catalytic nucleophile [active] 692420005528 Presynaptic Site I dimer interface [polypeptide binding]; other site 692420005529 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 692420005530 Synaptic Flat tetramer interface [polypeptide binding]; other site 692420005531 Synaptic Site I dimer interface [polypeptide binding]; other site 692420005532 DNA binding site [nucleotide binding] 692420005533 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 692420005534 DNA-binding interface [nucleotide binding]; DNA binding site 692420005535 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 692420005536 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 692420005537 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 692420005538 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 692420005539 stage V sporulation protein AD; Provisional; Region: PRK12404 692420005540 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 692420005541 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 692420005542 Predicted membrane protein [Function unknown]; Region: COG2323 692420005543 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 692420005544 Predicted membrane protein [Function unknown]; Region: COG2323 692420005545 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 692420005546 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 692420005547 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 692420005548 putative active site [active] 692420005549 catalytic site [active] 692420005550 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 692420005551 putative active site [active] 692420005552 catalytic site [active] 692420005553 DinB family; Region: DinB; cl17821 692420005554 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 692420005555 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 692420005556 NAD binding site [chemical binding]; other site 692420005557 substrate binding site [chemical binding]; other site 692420005558 catalytic Zn binding site [ion binding]; other site 692420005559 tetramer interface [polypeptide binding]; other site 692420005560 structural Zn binding site [ion binding]; other site 692420005561 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 692420005562 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 692420005563 YoaP-like; Region: YoaP; pfam14268 692420005564 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 692420005565 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 692420005566 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 692420005567 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 692420005568 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 692420005569 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 692420005570 Chitin binding domain; Region: Chitin_bind_3; pfam03067 692420005571 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 692420005572 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 692420005573 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 692420005574 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 692420005575 trimer interface [polypeptide binding]; other site 692420005576 active site 692420005577 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 692420005578 Protein of unknown function (DUF867); Region: DUF867; pfam05908 692420005579 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 692420005580 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 692420005581 LexA repressor; Validated; Region: PRK00215 692420005582 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420005583 putative DNA binding site [nucleotide binding]; other site 692420005584 putative Zn2+ binding site [ion binding]; other site 692420005585 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 692420005586 Catalytic site [active] 692420005587 cell division suppressor protein YneA; Provisional; Region: PRK14125 692420005588 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420005589 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 692420005590 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 692420005591 catalytic residues [active] 692420005592 catalytic nucleophile [active] 692420005593 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 692420005594 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 692420005595 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 692420005596 TPP-binding site [chemical binding]; other site 692420005597 dimer interface [polypeptide binding]; other site 692420005598 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 692420005599 PYR/PP interface [polypeptide binding]; other site 692420005600 dimer interface [polypeptide binding]; other site 692420005601 TPP binding site [chemical binding]; other site 692420005602 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 692420005603 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 692420005604 hypothetical protein; Provisional; Region: PRK01844 692420005605 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 692420005606 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 692420005607 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 692420005608 Response regulator receiver domain; Region: Response_reg; pfam00072 692420005609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420005610 active site 692420005611 phosphorylation site [posttranslational modification] 692420005612 intermolecular recognition site; other site 692420005613 dimerization interface [polypeptide binding]; other site 692420005614 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 692420005615 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 692420005616 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 692420005617 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 692420005618 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 692420005619 aconitate hydratase; Validated; Region: PRK09277 692420005620 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 692420005621 substrate binding site [chemical binding]; other site 692420005622 ligand binding site [chemical binding]; other site 692420005623 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 692420005624 substrate binding site [chemical binding]; other site 692420005625 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 692420005626 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 692420005627 catalytic residues [active] 692420005628 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 692420005629 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 692420005630 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 692420005631 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 692420005632 active site 692420005633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 692420005634 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 692420005635 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 692420005636 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 692420005637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420005638 ATP binding site [chemical binding]; other site 692420005639 Mg2+ binding site [ion binding]; other site 692420005640 G-X-G motif; other site 692420005641 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 692420005642 anchoring element; other site 692420005643 dimer interface [polypeptide binding]; other site 692420005644 ATP binding site [chemical binding]; other site 692420005645 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 692420005646 active site 692420005647 putative metal-binding site [ion binding]; other site 692420005648 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 692420005649 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 692420005650 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 692420005651 CAP-like domain; other site 692420005652 active site 692420005653 primary dimer interface [polypeptide binding]; other site 692420005654 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420005655 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420005656 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420005657 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 692420005658 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 692420005659 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 692420005660 potential frameshift: common BLAST hit: gi|154686235|ref|YP_001421396.1| YndG 692420005661 potential frameshift: common BLAST hit: gi|154686235|ref|YP_001421396.1| YndG 692420005662 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 692420005663 YndJ-like protein; Region: YndJ; pfam14158 692420005664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420005665 HAMP domain; Region: HAMP; pfam00672 692420005666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420005667 dimer interface [polypeptide binding]; other site 692420005668 phosphorylation site [posttranslational modification] 692420005669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420005670 ATP binding site [chemical binding]; other site 692420005671 Mg2+ binding site [ion binding]; other site 692420005672 G-X-G motif; other site 692420005673 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420005674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420005675 active site 692420005676 phosphorylation site [posttranslational modification] 692420005677 intermolecular recognition site; other site 692420005678 dimerization interface [polypeptide binding]; other site 692420005679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420005680 DNA binding site [nucleotide binding] 692420005681 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 692420005682 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 692420005683 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 692420005684 substrate binding site [chemical binding]; other site 692420005685 active site 692420005686 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 692420005687 metal binding site [ion binding]; metal-binding site 692420005688 ligand binding site [chemical binding]; other site 692420005689 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420005690 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 692420005691 acyl-activating enzyme (AAE) consensus motif; other site 692420005692 AMP binding site [chemical binding]; other site 692420005693 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005694 Condensation domain; Region: Condensation; pfam00668 692420005695 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005696 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 692420005697 Condensation domain; Region: Condensation; pfam00668 692420005698 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005699 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420005700 acyl-activating enzyme (AAE) consensus motif; other site 692420005701 AMP binding site [chemical binding]; other site 692420005702 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005703 Thioesterase domain; Region: Thioesterase; pfam00975 692420005704 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420005705 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 692420005706 acyl-activating enzyme (AAE) consensus motif; other site 692420005707 AMP binding site [chemical binding]; other site 692420005708 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005709 Condensation domain; Region: Condensation; pfam00668 692420005710 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005711 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 692420005712 Condensation domain; Region: Condensation; pfam00668 692420005713 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420005714 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 692420005715 acyl-activating enzyme (AAE) consensus motif; other site 692420005716 AMP binding site [chemical binding]; other site 692420005717 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005718 Condensation domain; Region: Condensation; pfam00668 692420005719 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005720 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 692420005721 Condensation domain; Region: Condensation; pfam00668 692420005722 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005723 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420005724 acyl-activating enzyme (AAE) consensus motif; other site 692420005725 AMP binding site [chemical binding]; other site 692420005726 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005727 Condensation domain; Region: Condensation; pfam00668 692420005728 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005729 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005730 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420005731 acyl-activating enzyme (AAE) consensus motif; other site 692420005732 AMP binding site [chemical binding]; other site 692420005733 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005734 Condensation domain; Region: Condensation; pfam00668 692420005735 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005736 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005737 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 692420005738 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 692420005739 acyl-activating enzyme (AAE) consensus motif; other site 692420005740 putative AMP binding site [chemical binding]; other site 692420005741 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005742 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 692420005743 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 692420005744 active site 692420005745 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005746 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 692420005747 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420005748 inhibitor-cofactor binding pocket; inhibition site 692420005749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420005750 catalytic residue [active] 692420005751 Condensation domain; Region: Condensation; pfam00668 692420005752 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005753 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005754 Condensation domain; Region: Condensation; pfam00668 692420005755 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005756 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005757 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420005758 acyl-activating enzyme (AAE) consensus motif; other site 692420005759 AMP binding site [chemical binding]; other site 692420005760 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005761 Condensation domain; Region: Condensation; pfam00668 692420005762 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005763 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005764 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 692420005765 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 692420005766 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 692420005767 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 692420005768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420005769 NAD(P) binding site [chemical binding]; other site 692420005770 active site 692420005771 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 692420005772 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 692420005773 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 692420005774 Cytochrome P450; Region: p450; cl12078 692420005775 biotin synthase; Validated; Region: PRK06256 692420005776 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420005777 FeS/SAM binding site; other site 692420005778 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 692420005779 AAA domain; Region: AAA_26; pfam13500 692420005780 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 692420005781 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 692420005782 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 692420005783 substrate-cofactor binding pocket; other site 692420005784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420005785 catalytic residue [active] 692420005786 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 692420005787 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420005788 inhibitor-cofactor binding pocket; inhibition site 692420005789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420005790 catalytic residue [active] 692420005791 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 692420005792 Predicted membrane protein [Function unknown]; Region: COG2246 692420005793 GtrA-like protein; Region: GtrA; pfam04138 692420005794 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 692420005795 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 692420005796 active site 692420005797 tetramer interface; other site 692420005798 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 692420005799 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 692420005800 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 692420005801 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 692420005802 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 692420005803 enoyl-CoA hydratase; Provisional; Region: PRK07657 692420005804 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420005805 substrate binding site [chemical binding]; other site 692420005806 oxyanion hole (OAH) forming residues; other site 692420005807 trimer interface [polypeptide binding]; other site 692420005808 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 692420005809 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 692420005810 active site 692420005811 catalytic residues [active] 692420005812 metal binding site [ion binding]; metal-binding site 692420005813 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 692420005814 carboxyltransferase (CT) interaction site; other site 692420005815 biotinylation site [posttranslational modification]; other site 692420005816 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 692420005817 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420005818 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 692420005819 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 692420005820 potential frameshift: common BLAST hit: gi|154686271|ref|YP_001421432.1| AMP-binding domain protein 692420005821 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 692420005822 acyl-activating enzyme (AAE) consensus motif; other site 692420005823 putative AMP binding site [chemical binding]; other site 692420005824 putative active site [active] 692420005825 putative CoA binding site [chemical binding]; other site 692420005826 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 692420005827 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 692420005828 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 692420005829 FAD binding site [chemical binding]; other site 692420005830 homotetramer interface [polypeptide binding]; other site 692420005831 substrate binding pocket [chemical binding]; other site 692420005832 catalytic base [active] 692420005833 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 692420005834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 692420005835 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 692420005836 Condensation domain; Region: Condensation; pfam00668 692420005837 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005838 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 692420005839 acyl-activating enzyme (AAE) consensus motif; other site 692420005840 AMP binding site [chemical binding]; other site 692420005841 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005842 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 692420005843 Condensation domain; Region: Condensation; pfam00668 692420005844 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005845 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005846 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420005847 acyl-activating enzyme (AAE) consensus motif; other site 692420005848 AMP binding site [chemical binding]; other site 692420005849 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005850 Condensation domain; Region: Condensation; pfam00668 692420005851 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420005852 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420005853 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420005854 acyl-activating enzyme (AAE) consensus motif; other site 692420005855 AMP binding site [chemical binding]; other site 692420005856 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420005857 Condensation domain; Region: Condensation; pfam00668 692420005858 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 692420005859 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 692420005860 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 692420005861 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 692420005862 active site 692420005863 catalytic residues [active] 692420005864 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 692420005865 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 692420005866 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 692420005867 Int/Topo IB signature motif; other site 692420005868 Helix-turn-helix domain; Region: HTH_17; cl17695 692420005869 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 692420005870 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 692420005871 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420005872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420005873 putative substrate translocation pore; other site 692420005874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420005875 dimerization interface [polypeptide binding]; other site 692420005876 putative DNA binding site [nucleotide binding]; other site 692420005877 putative Zn2+ binding site [ion binding]; other site 692420005878 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 692420005879 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 692420005880 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 692420005881 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 692420005882 active site 692420005883 dimer interface [polypeptide binding]; other site 692420005884 motif 1; other site 692420005885 motif 2; other site 692420005886 motif 3; other site 692420005887 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 692420005888 anticodon binding site; other site 692420005889 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 692420005890 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 692420005891 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 692420005892 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 692420005893 active site 692420005894 dimer interface [polypeptide binding]; other site 692420005895 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 692420005896 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 692420005897 active site 692420005898 FMN binding site [chemical binding]; other site 692420005899 substrate binding site [chemical binding]; other site 692420005900 3Fe-4S cluster binding site [ion binding]; other site 692420005901 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 692420005902 domain interface; other site 692420005903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420005904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 692420005905 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 692420005906 putative dimerization interface [polypeptide binding]; other site 692420005907 gamma-glutamyl kinase; Provisional; Region: PRK13402 692420005908 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 692420005909 nucleotide binding site [chemical binding]; other site 692420005910 homotetrameric interface [polypeptide binding]; other site 692420005911 putative phosphate binding site [ion binding]; other site 692420005912 putative allosteric binding site; other site 692420005913 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 692420005914 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 692420005915 Replication terminator protein; Region: RTP; pfam02334 692420005916 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 692420005917 classical (c) SDRs; Region: SDR_c; cd05233 692420005918 NAD(P) binding site [chemical binding]; other site 692420005919 active site 692420005920 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 692420005921 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 692420005922 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 692420005923 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 692420005924 putative active site [active] 692420005925 catalytic site [active] 692420005926 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 692420005927 putative active site [active] 692420005928 catalytic site [active] 692420005929 Predicted membrane protein [Function unknown]; Region: COG2323 692420005930 Predicted membrane protein [Function unknown]; Region: COG2323 692420005931 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 692420005932 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 692420005933 stage V sporulation protein AD; Provisional; Region: PRK12404 692420005934 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 692420005935 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 692420005936 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 692420005937 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 692420005938 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 692420005939 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 692420005940 catalytic residues [active] 692420005941 catalytic nucleophile [active] 692420005942 Presynaptic Site I dimer interface [polypeptide binding]; other site 692420005943 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 692420005944 Synaptic Flat tetramer interface [polypeptide binding]; other site 692420005945 Synaptic Site I dimer interface [polypeptide binding]; other site 692420005946 DNA binding site [nucleotide binding] 692420005947 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 692420005948 DNA-binding interface [nucleotide binding]; DNA binding site 692420005949 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 692420005950 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 692420005951 polyol permease family; Region: 2A0118; TIGR00897 692420005952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420005953 putative substrate translocation pore; other site 692420005954 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 692420005955 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 692420005956 putative N- and C-terminal domain interface [polypeptide binding]; other site 692420005957 putative active site [active] 692420005958 putative MgATP binding site [chemical binding]; other site 692420005959 catalytic site [active] 692420005960 metal binding site [ion binding]; metal-binding site 692420005961 carbohydrate binding site [chemical binding]; other site 692420005962 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 692420005963 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 692420005964 putative ligand binding site [chemical binding]; other site 692420005965 putative NAD binding site [chemical binding]; other site 692420005966 catalytic site [active] 692420005967 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 692420005968 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 692420005969 putative [4Fe-4S] binding site [ion binding]; other site 692420005970 putative molybdopterin cofactor binding site [chemical binding]; other site 692420005971 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 692420005972 putative molybdopterin cofactor binding site; other site 692420005973 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420005974 MarR family; Region: MarR_2; pfam12802 692420005975 MarR family; Region: MarR_2; cl17246 692420005976 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 692420005977 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 692420005978 dimer interface [polypeptide binding]; other site 692420005979 putative tRNA-binding site [nucleotide binding]; other site 692420005980 Cupin domain; Region: Cupin_2; pfam07883 692420005981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420005982 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 692420005983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420005984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420005985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420005986 WHG domain; Region: WHG; pfam13305 692420005987 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 692420005988 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420005989 dimerization interface [polypeptide binding]; other site 692420005990 putative DNA binding site [nucleotide binding]; other site 692420005991 putative Zn2+ binding site [ion binding]; other site 692420005992 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 692420005993 N-acetyl-D-glucosamine binding site [chemical binding]; other site 692420005994 catalytic residue [active] 692420005995 Predicted membrane protein [Function unknown]; Region: COG2322 692420005996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 692420005997 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 692420005998 putative dimer interface [polypeptide binding]; other site 692420005999 catalytic triad [active] 692420006000 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420006001 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420006002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 692420006003 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 692420006004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420006005 ATP binding site [chemical binding]; other site 692420006006 putative Mg++ binding site [ion binding]; other site 692420006007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420006008 nucleotide binding region [chemical binding]; other site 692420006009 ATP-binding site [chemical binding]; other site 692420006010 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 692420006011 HRDC domain; Region: HRDC; pfam00570 692420006012 azoreductase; Provisional; Region: PRK13556 692420006013 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 692420006014 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 692420006015 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 692420006016 putative dimer interface [polypeptide binding]; other site 692420006017 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 692420006018 pentamer interface [polypeptide binding]; other site 692420006019 dodecaamer interface [polypeptide binding]; other site 692420006020 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 692420006021 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 692420006022 NAD(P) binding site [chemical binding]; other site 692420006023 catalytic residues [active] 692420006024 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 692420006025 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 692420006026 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 692420006027 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 692420006028 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 692420006029 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 692420006030 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 692420006031 Na2 binding site [ion binding]; other site 692420006032 putative substrate binding site 1 [chemical binding]; other site 692420006033 Na binding site 1 [ion binding]; other site 692420006034 putative substrate binding site 2 [chemical binding]; other site 692420006035 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 692420006036 Sodium Bile acid symporter family; Region: SBF; pfam01758 692420006037 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 692420006038 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 692420006039 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 692420006040 E3 interaction surface; other site 692420006041 lipoyl attachment site [posttranslational modification]; other site 692420006042 e3 binding domain; Region: E3_binding; pfam02817 692420006043 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 692420006044 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 692420006045 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 692420006046 TPP-binding site [chemical binding]; other site 692420006047 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 692420006048 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 692420006049 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 692420006050 metal ion-dependent adhesion site (MIDAS); other site 692420006051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420006052 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 692420006053 Walker A motif; other site 692420006054 ATP binding site [chemical binding]; other site 692420006055 Walker B motif; other site 692420006056 arginine finger; other site 692420006057 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 692420006058 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 692420006059 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 692420006060 E-class dimer interface [polypeptide binding]; other site 692420006061 P-class dimer interface [polypeptide binding]; other site 692420006062 active site 692420006063 Cu2+ binding site [ion binding]; other site 692420006064 Zn2+ binding site [ion binding]; other site 692420006065 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420006066 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 692420006067 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420006068 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 692420006069 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420006070 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420006071 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 692420006072 NlpC/P60 family; Region: NLPC_P60; pfam00877 692420006073 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 692420006074 glycosyltransferase, MGT family; Region: MGT; TIGR01426 692420006075 active site 692420006076 TDP-binding site; other site 692420006077 acceptor substrate-binding pocket; other site 692420006078 homodimer interface [polypeptide binding]; other site 692420006079 Uncharacterized conserved protein [Function unknown]; Region: COG1624 692420006080 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 692420006081 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 692420006082 multidrug efflux protein; Reviewed; Region: PRK01766 692420006083 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 692420006084 cation binding site [ion binding]; other site 692420006085 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420006086 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 692420006087 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 692420006088 Predicted permeases [General function prediction only]; Region: RarD; COG2962 692420006089 EamA-like transporter family; Region: EamA; pfam00892 692420006090 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 692420006091 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 692420006092 Predicted transcriptional regulators [Transcription]; Region: COG1733 692420006093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420006094 dimerization interface [polypeptide binding]; other site 692420006095 putative DNA binding site [nucleotide binding]; other site 692420006096 putative Zn2+ binding site [ion binding]; other site 692420006097 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 692420006098 dimer interface [polypeptide binding]; other site 692420006099 FMN binding site [chemical binding]; other site 692420006100 Predicted esterase [General function prediction only]; Region: COG0400 692420006101 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 692420006102 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420006103 Zn binding site [ion binding]; other site 692420006104 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 692420006105 Zn binding site [ion binding]; other site 692420006106 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 692420006107 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 692420006108 Na binding site [ion binding]; other site 692420006109 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 692420006110 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 692420006111 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 692420006112 beta-galactosidase; Region: BGL; TIGR03356 692420006113 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 692420006114 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420006115 DNA-binding site [nucleotide binding]; DNA binding site 692420006116 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 692420006117 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 692420006118 C-terminal peptidase (prc); Region: prc; TIGR00225 692420006119 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 692420006120 protein binding site [polypeptide binding]; other site 692420006121 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 692420006122 Catalytic dyad [active] 692420006123 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 692420006124 Methyltransferase domain; Region: Methyltransf_31; pfam13847 692420006125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420006126 S-adenosylmethionine binding site [chemical binding]; other site 692420006127 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 692420006128 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 692420006129 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 692420006130 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 692420006131 YodL-like; Region: YodL; pfam14191 692420006132 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 692420006133 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 692420006134 active site 692420006135 YozD-like protein; Region: YozD; pfam14162 692420006136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420006137 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 692420006138 hypothetical protein; Provisional; Region: PRK13672 692420006139 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 692420006140 Zn binding site [ion binding]; other site 692420006141 toxin interface [polypeptide binding]; other site 692420006142 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 692420006143 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420006144 FeS/SAM binding site; other site 692420006145 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 692420006146 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 692420006147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420006148 Coenzyme A binding pocket [chemical binding]; other site 692420006149 acetylornithine deacetylase; Validated; Region: PRK06915 692420006150 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 692420006151 metal binding site [ion binding]; metal-binding site 692420006152 dimer interface [polypeptide binding]; other site 692420006153 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 692420006154 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 692420006155 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420006156 hypothetical protein; Provisional; Region: PRK06917 692420006157 inhibitor-cofactor binding pocket; inhibition site 692420006158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420006159 catalytic residue [active] 692420006160 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 692420006161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420006162 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 692420006163 Coenzyme A binding pocket [chemical binding]; other site 692420006164 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 692420006165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420006166 active site 692420006167 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 692420006168 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 692420006169 Phytase; Region: Phytase; cl17685 692420006170 similar to capsular polysaccharide biosynthesis enzyme fragment; N-terminal part of YpqP 692420006171 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 692420006172 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 692420006173 putative active site [active] 692420006174 putative substrate binding site [chemical binding]; other site 692420006175 putative FMN binding site [chemical binding]; other site 692420006176 putative catalytic residues [active] 692420006177 Regulatory protein YrvL; Region: YrvL; pfam14184 692420006178 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 692420006179 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 692420006180 catalytic residues [active] 692420006181 catalytic nucleophile [active] 692420006182 Recombinase; Region: Recombinase; pfam07508 692420006183 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 692420006184 similar to capsular polysaccharide biosynthesis enzyme fragment; C-terminal part of YpqP 692420006185 methionine sulfoxide reductase B; Provisional; Region: PRK00222 692420006186 SelR domain; Region: SelR; pfam01641 692420006187 methionine sulfoxide reductase A; Provisional; Region: PRK14054 692420006188 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420006189 MarR family; Region: MarR; pfam01047 692420006190 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 692420006191 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 692420006192 active site 692420006193 catalytic triad [active] 692420006194 oxyanion hole [active] 692420006195 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 692420006196 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 692420006197 Cu(I) binding site [ion binding]; other site 692420006198 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 692420006199 threonine dehydratase; Validated; Region: PRK08639 692420006200 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 692420006201 tetramer interface [polypeptide binding]; other site 692420006202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420006203 catalytic residue [active] 692420006204 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 692420006205 putative Ile/Val binding site [chemical binding]; other site 692420006206 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 692420006207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420006208 Walker A motif; other site 692420006209 ATP binding site [chemical binding]; other site 692420006210 Walker B motif; other site 692420006211 arginine finger; other site 692420006212 Haemolysin-III related; Region: HlyIII; cl03831 692420006213 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 692420006214 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 692420006215 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 692420006216 putative acyl-acceptor binding pocket; other site 692420006217 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 692420006218 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 692420006219 folate binding site [chemical binding]; other site 692420006220 NADP+ binding site [chemical binding]; other site 692420006221 thymidylate synthase; Reviewed; Region: thyA; PRK01827 692420006222 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 692420006223 dimerization interface [polypeptide binding]; other site 692420006224 active site 692420006225 YpjP-like protein; Region: YpjP; pfam14005 692420006226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420006227 S-adenosylmethionine binding site [chemical binding]; other site 692420006228 Disulphide isomerase; Region: Disulph_isomer; pfam06491 692420006229 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 692420006230 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 692420006231 Virulence factor; Region: Virulence_fact; pfam13769 692420006232 HEAT repeats; Region: HEAT_2; pfam13646 692420006233 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 692420006234 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 692420006235 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 692420006236 Zn2+ binding site [ion binding]; other site 692420006237 Mg2+ binding site [ion binding]; other site 692420006238 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 692420006239 catalytic residues [active] 692420006240 dimer interface [polypeptide binding]; other site 692420006241 homoserine O-succinyltransferase; Provisional; Region: PRK05368 692420006242 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 692420006243 proposed active site lysine [active] 692420006244 conserved cys residue [active] 692420006245 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 692420006246 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 692420006247 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 692420006248 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 692420006249 DNA-binding site [nucleotide binding]; DNA binding site 692420006250 RNA-binding motif; other site 692420006251 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 692420006252 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 692420006253 hypothetical protein; Validated; Region: PRK07708 692420006254 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 692420006255 RNA/DNA hybrid binding site [nucleotide binding]; other site 692420006256 active site 692420006257 conserved hypothetical integral membrane protein; Region: TIGR00697 692420006258 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 692420006259 RNA/DNA hybrid binding site [nucleotide binding]; other site 692420006260 active site 692420006261 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 692420006262 5'-3' exonuclease; Region: 53EXOc; smart00475 692420006263 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 692420006264 active site 692420006265 metal binding site 1 [ion binding]; metal-binding site 692420006266 putative 5' ssDNA interaction site; other site 692420006267 metal binding site 3; metal-binding site 692420006268 metal binding site 2 [ion binding]; metal-binding site 692420006269 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 692420006270 putative DNA binding site [nucleotide binding]; other site 692420006271 putative metal binding site [ion binding]; other site 692420006272 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 692420006273 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 692420006274 Dynamin family; Region: Dynamin_N; pfam00350 692420006275 G1 box; other site 692420006276 GTP/Mg2+ binding site [chemical binding]; other site 692420006277 G2 box; other site 692420006278 Switch I region; other site 692420006279 G3 box; other site 692420006280 Switch II region; other site 692420006281 G4 box; other site 692420006282 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 692420006283 G1 box; other site 692420006284 GTP/Mg2+ binding site [chemical binding]; other site 692420006285 Dynamin family; Region: Dynamin_N; pfam00350 692420006286 G2 box; other site 692420006287 Switch I region; other site 692420006288 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 692420006289 G3 box; other site 692420006290 Switch II region; other site 692420006291 GTP/Mg2+ binding site [chemical binding]; other site 692420006292 G4 box; other site 692420006293 G5 box; other site 692420006294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 692420006295 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 692420006296 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 692420006297 malonyl-CoA binding site [chemical binding]; other site 692420006298 dimer interface [polypeptide binding]; other site 692420006299 active site 692420006300 product binding site; other site 692420006301 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 692420006302 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 692420006303 DNA binding site [nucleotide binding] 692420006304 active site 692420006305 xanthine permease; Region: pbuX; TIGR03173 692420006306 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420006307 active site 692420006308 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 692420006309 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 692420006310 active site 692420006311 Zn binding site [ion binding]; other site 692420006312 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 692420006313 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 692420006314 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 692420006315 YpzG-like protein; Region: YpzG; pfam14139 692420006316 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 692420006317 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 692420006318 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 692420006319 cell division protein GpsB; Provisional; Region: PRK14127 692420006320 DivIVA domain; Region: DivI1A_domain; TIGR03544 692420006321 hypothetical protein; Provisional; Region: PRK13660 692420006322 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 692420006323 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 692420006324 RNase_H superfamily; Region: RNase_H_2; pfam13482 692420006325 active site 692420006326 substrate binding site [chemical binding]; other site 692420006327 catalytic site [active] 692420006328 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 692420006329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420006330 ATP binding site [chemical binding]; other site 692420006331 putative Mg++ binding site [ion binding]; other site 692420006332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420006333 nucleotide binding region [chemical binding]; other site 692420006334 ATP-binding site [chemical binding]; other site 692420006335 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 692420006336 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 692420006337 HPr interaction site; other site 692420006338 glycerol kinase (GK) interaction site [polypeptide binding]; other site 692420006339 active site 692420006340 phosphorylation site [posttranslational modification] 692420006341 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 692420006342 YppG-like protein; Region: YppG; pfam14179 692420006343 YppF-like protein; Region: YppF; pfam14178 692420006344 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 692420006345 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 692420006346 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 692420006347 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 692420006348 Transglycosylase; Region: Transgly; pfam00912 692420006349 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 692420006350 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 692420006351 Interdomain contacts; other site 692420006352 Cytokine receptor motif; other site 692420006353 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 692420006354 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 692420006355 minor groove reading motif; other site 692420006356 helix-hairpin-helix signature motif; other site 692420006357 substrate binding pocket [chemical binding]; other site 692420006358 active site 692420006359 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 692420006360 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 692420006361 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 692420006362 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 692420006363 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 692420006364 putative dimer interface [polypeptide binding]; other site 692420006365 putative anticodon binding site; other site 692420006366 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 692420006367 homodimer interface [polypeptide binding]; other site 692420006368 motif 1; other site 692420006369 motif 2; other site 692420006370 active site 692420006371 motif 3; other site 692420006372 aspartate aminotransferase; Provisional; Region: PRK05764 692420006373 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420006374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420006375 homodimer interface [polypeptide binding]; other site 692420006376 catalytic residue [active] 692420006377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 692420006378 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 692420006379 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 692420006380 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 692420006381 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 692420006382 active site 692420006383 catalytic site [active] 692420006384 substrate binding site [chemical binding]; other site 692420006385 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 692420006386 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 692420006387 tetramerization interface [polypeptide binding]; other site 692420006388 active site 692420006389 Pantoate-beta-alanine ligase; Region: PanC; cd00560 692420006390 pantoate--beta-alanine ligase; Region: panC; TIGR00018 692420006391 active site 692420006392 ATP-binding site [chemical binding]; other site 692420006393 pantoate-binding site; other site 692420006394 HXXH motif; other site 692420006395 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 692420006396 oligomerization interface [polypeptide binding]; other site 692420006397 active site 692420006398 metal binding site [ion binding]; metal-binding site 692420006399 Biotin operon repressor [Transcription]; Region: BirA; COG1654 692420006400 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 692420006401 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 692420006402 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 692420006403 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 692420006404 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 692420006405 active site 692420006406 NTP binding site [chemical binding]; other site 692420006407 metal binding triad [ion binding]; metal-binding site 692420006408 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 692420006409 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 692420006410 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 692420006411 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 692420006412 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 692420006413 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 692420006414 active site 692420006415 dimer interfaces [polypeptide binding]; other site 692420006416 catalytic residues [active] 692420006417 dihydrodipicolinate reductase; Region: dapB; TIGR00036 692420006418 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 692420006419 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 692420006420 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 692420006421 homodimer interface [polypeptide binding]; other site 692420006422 metal binding site [ion binding]; metal-binding site 692420006423 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420006424 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420006425 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420006426 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 692420006427 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 692420006428 Cupin; Region: Cupin_1; smart00835 692420006429 Cupin; Region: Cupin_1; smart00835 692420006430 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 692420006431 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 692420006432 Qo binding site; other site 692420006433 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 692420006434 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 692420006435 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 692420006436 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 692420006437 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 692420006438 interchain domain interface [polypeptide binding]; other site 692420006439 intrachain domain interface; other site 692420006440 heme bH binding site [chemical binding]; other site 692420006441 Qi binding site; other site 692420006442 heme bL binding site [chemical binding]; other site 692420006443 Qo binding site; other site 692420006444 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 692420006445 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 692420006446 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 692420006447 iron-sulfur cluster [ion binding]; other site 692420006448 [2Fe-2S] cluster binding site [ion binding]; other site 692420006449 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 692420006450 hypothetical protein; Provisional; Region: PRK03636 692420006451 UPF0302 domain; Region: UPF0302; pfam08864 692420006452 IDEAL domain; Region: IDEAL; pfam08858 692420006453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420006454 TPR motif; other site 692420006455 binding surface 692420006456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420006457 binding surface 692420006458 TPR motif; other site 692420006459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420006460 TPR motif; other site 692420006461 binding surface 692420006462 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 692420006463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420006464 binding surface 692420006465 TPR motif; other site 692420006466 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 692420006467 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 692420006468 hinge; other site 692420006469 active site 692420006470 prephenate dehydrogenase; Validated; Region: PRK06545 692420006471 prephenate dehydrogenase; Validated; Region: PRK08507 692420006472 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 692420006473 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 692420006474 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420006475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420006476 homodimer interface [polypeptide binding]; other site 692420006477 catalytic residue [active] 692420006478 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 692420006479 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 692420006480 substrate binding site [chemical binding]; other site 692420006481 active site 692420006482 catalytic residues [active] 692420006483 heterodimer interface [polypeptide binding]; other site 692420006484 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 692420006485 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 692420006486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420006487 catalytic residue [active] 692420006488 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 692420006489 active site 692420006490 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 692420006491 active site 692420006492 ribulose/triose binding site [chemical binding]; other site 692420006493 phosphate binding site [ion binding]; other site 692420006494 substrate (anthranilate) binding pocket [chemical binding]; other site 692420006495 product (indole) binding pocket [chemical binding]; other site 692420006496 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 692420006497 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 692420006498 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 692420006499 anthranilate synthase component I; Provisional; Region: PRK13569 692420006500 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 692420006501 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 692420006502 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 692420006503 homotrimer interaction site [polypeptide binding]; other site 692420006504 active site 692420006505 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 692420006506 active site 692420006507 dimer interface [polypeptide binding]; other site 692420006508 metal binding site [ion binding]; metal-binding site 692420006509 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 692420006510 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 692420006511 Tetramer interface [polypeptide binding]; other site 692420006512 active site 692420006513 FMN-binding site [chemical binding]; other site 692420006514 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 692420006515 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 692420006516 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 692420006517 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 692420006518 active site 692420006519 multimer interface [polypeptide binding]; other site 692420006520 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 692420006521 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 692420006522 substrate binding pocket [chemical binding]; other site 692420006523 chain length determination region; other site 692420006524 substrate-Mg2+ binding site; other site 692420006525 catalytic residues [active] 692420006526 aspartate-rich region 1; other site 692420006527 active site lid residues [active] 692420006528 aspartate-rich region 2; other site 692420006529 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 692420006530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420006531 S-adenosylmethionine binding site [chemical binding]; other site 692420006532 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 692420006533 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 692420006534 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 692420006535 homodecamer interface [polypeptide binding]; other site 692420006536 GTP cyclohydrolase I; Provisional; Region: PLN03044 692420006537 active site 692420006538 putative catalytic site residues [active] 692420006539 zinc binding site [ion binding]; other site 692420006540 GTP-CH-I/GFRP interaction surface; other site 692420006541 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 692420006542 IHF dimer interface [polypeptide binding]; other site 692420006543 IHF - DNA interface [nucleotide binding]; other site 692420006544 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 692420006545 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 692420006546 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 692420006547 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 692420006548 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 692420006549 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 692420006550 GTP-binding protein Der; Reviewed; Region: PRK00093 692420006551 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 692420006552 G1 box; other site 692420006553 GTP/Mg2+ binding site [chemical binding]; other site 692420006554 Switch I region; other site 692420006555 G2 box; other site 692420006556 Switch II region; other site 692420006557 G3 box; other site 692420006558 G4 box; other site 692420006559 G5 box; other site 692420006560 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 692420006561 G1 box; other site 692420006562 GTP/Mg2+ binding site [chemical binding]; other site 692420006563 Switch I region; other site 692420006564 G2 box; other site 692420006565 G3 box; other site 692420006566 Switch II region; other site 692420006567 G4 box; other site 692420006568 G5 box; other site 692420006569 YpzI-like protein; Region: YpzI; pfam14140 692420006570 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 692420006571 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 692420006572 homotetramer interface [polypeptide binding]; other site 692420006573 FMN binding site [chemical binding]; other site 692420006574 homodimer contacts [polypeptide binding]; other site 692420006575 putative active site [active] 692420006576 putative substrate binding site [chemical binding]; other site 692420006577 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 692420006578 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 692420006579 RNA binding site [nucleotide binding]; other site 692420006580 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 692420006581 RNA binding site [nucleotide binding]; other site 692420006582 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 692420006583 RNA binding site [nucleotide binding]; other site 692420006584 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 692420006585 RNA binding site [nucleotide binding]; other site 692420006586 cytidylate kinase; Provisional; Region: cmk; PRK00023 692420006587 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 692420006588 CMP-binding site; other site 692420006589 The sites determining sugar specificity; other site 692420006590 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 692420006591 Flagellar protein YcgR; Region: YcgR_2; pfam12945 692420006592 PilZ domain; Region: PilZ; pfam07238 692420006593 germination protein YpeB; Region: spore_YpeB; TIGR02889 692420006594 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 692420006595 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 692420006596 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 692420006597 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 692420006598 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 692420006599 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 692420006600 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 692420006601 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 692420006602 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 692420006603 NAD(P) binding site [chemical binding]; other site 692420006604 adaptor protein; Provisional; Region: PRK02899 692420006605 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 692420006606 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 692420006607 putative active site [active] 692420006608 putative metal binding site [ion binding]; other site 692420006609 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 692420006610 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420006611 CAAX protease self-immunity; Region: Abi; pfam02517 692420006612 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 692420006613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420006614 ATP binding site [chemical binding]; other site 692420006615 putative Mg++ binding site [ion binding]; other site 692420006616 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420006617 nucleotide binding region [chemical binding]; other site 692420006618 ATP-binding site [chemical binding]; other site 692420006619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 692420006620 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 692420006621 Predicted membrane protein [Function unknown]; Region: COG3601 692420006622 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 692420006623 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 692420006624 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 692420006625 ligand binding site [chemical binding]; other site 692420006626 NAD binding site [chemical binding]; other site 692420006627 dimerization interface [polypeptide binding]; other site 692420006628 catalytic site [active] 692420006629 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 692420006630 putative L-serine binding site [chemical binding]; other site 692420006631 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 692420006632 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420006633 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420006634 DNA binding residues [nucleotide binding] 692420006635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 692420006636 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420006637 dimerization interface [polypeptide binding]; other site 692420006638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420006639 putative active site [active] 692420006640 heme pocket [chemical binding]; other site 692420006641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420006642 dimer interface [polypeptide binding]; other site 692420006643 phosphorylation site [posttranslational modification] 692420006644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420006645 ATP binding site [chemical binding]; other site 692420006646 Mg2+ binding site [ion binding]; other site 692420006647 G-X-G motif; other site 692420006648 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420006649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420006650 active site 692420006651 phosphorylation site [posttranslational modification] 692420006652 intermolecular recognition site; other site 692420006653 dimerization interface [polypeptide binding]; other site 692420006654 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420006655 DNA binding site [nucleotide binding] 692420006656 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 692420006657 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 692420006658 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 692420006659 ResB-like family; Region: ResB; pfam05140 692420006660 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 692420006661 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 692420006662 catalytic residues [active] 692420006663 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 692420006664 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420006665 RNA binding surface [nucleotide binding]; other site 692420006666 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 692420006667 active site 692420006668 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 692420006669 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 692420006670 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 692420006671 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 692420006672 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 692420006673 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 692420006674 segregation and condensation protein B; Region: TIGR00281 692420006675 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 692420006676 Domain of unknown function (DUF309); Region: DUF309; cl00667 692420006677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420006678 Coenzyme A binding pocket [chemical binding]; other site 692420006679 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 692420006680 homopentamer interface [polypeptide binding]; other site 692420006681 active site 692420006682 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 692420006683 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 692420006684 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 692420006685 dimerization interface [polypeptide binding]; other site 692420006686 active site 692420006687 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 692420006688 Lumazine binding domain; Region: Lum_binding; pfam00677 692420006689 Lumazine binding domain; Region: Lum_binding; pfam00677 692420006690 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 692420006691 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 692420006692 catalytic motif [active] 692420006693 Zn binding site [ion binding]; other site 692420006694 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 692420006695 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 692420006696 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 692420006697 Catalytic site [active] 692420006698 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 692420006699 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 692420006700 active site 692420006701 Predicted secreted protein [Function unknown]; Region: COG4086 692420006702 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 692420006703 diaminopimelate decarboxylase; Region: lysA; TIGR01048 692420006704 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 692420006705 active site 692420006706 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 692420006707 substrate binding site [chemical binding]; other site 692420006708 catalytic residues [active] 692420006709 dimer interface [polypeptide binding]; other site 692420006710 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 692420006711 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 692420006712 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 692420006713 stage V sporulation protein AD; Validated; Region: PRK08304 692420006714 stage V sporulation protein AD; Provisional; Region: PRK12404 692420006715 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 692420006716 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 692420006717 sporulation sigma factor SigF; Validated; Region: PRK05572 692420006718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420006719 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 692420006720 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420006721 DNA binding residues [nucleotide binding] 692420006722 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 692420006723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420006724 ATP binding site [chemical binding]; other site 692420006725 Mg2+ binding site [ion binding]; other site 692420006726 G-X-G motif; other site 692420006727 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 692420006728 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 692420006729 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 692420006730 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 692420006731 purine nucleoside phosphorylase; Provisional; Region: PRK08202 692420006732 phosphopentomutase; Provisional; Region: PRK05362 692420006733 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 692420006734 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 692420006735 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 692420006736 active site 692420006737 Int/Topo IB signature motif; other site 692420006738 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 692420006739 ferric uptake regulator; Provisional; Region: fur; PRK09462 692420006740 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 692420006741 metal binding site 2 [ion binding]; metal-binding site 692420006742 putative DNA binding helix; other site 692420006743 metal binding site 1 [ion binding]; metal-binding site 692420006744 dimer interface [polypeptide binding]; other site 692420006745 structural Zn2+ binding site [ion binding]; other site 692420006746 stage II sporulation protein M; Region: spo_II_M; TIGR02831 692420006747 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 692420006748 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 692420006749 Malic enzyme, N-terminal domain; Region: malic; pfam00390 692420006750 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 692420006751 NAD(P) binding pocket [chemical binding]; other site 692420006752 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 692420006753 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 692420006754 Aspartase; Region: Aspartase; cd01357 692420006755 active sites [active] 692420006756 tetramer interface [polypeptide binding]; other site 692420006757 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 692420006758 active site 692420006759 homodimer interface [polypeptide binding]; other site 692420006760 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420006761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420006762 non-specific DNA binding site [nucleotide binding]; other site 692420006763 salt bridge; other site 692420006764 sequence-specific DNA binding site [nucleotide binding]; other site 692420006765 TIGR00375 family protein; Region: TIGR00375 692420006766 PHP-associated; Region: PHP_C; pfam13263 692420006767 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 692420006768 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 692420006769 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 692420006770 dimer interface [polypeptide binding]; other site 692420006771 ADP-ribose binding site [chemical binding]; other site 692420006772 active site 692420006773 nudix motif; other site 692420006774 metal binding site [ion binding]; metal-binding site 692420006775 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 692420006776 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420006777 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420006778 active site 692420006779 catalytic tetrad [active] 692420006780 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 692420006781 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 692420006782 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 692420006783 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 692420006784 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 692420006785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 692420006786 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 692420006787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420006788 Coenzyme A binding pocket [chemical binding]; other site 692420006789 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 692420006790 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 692420006791 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420006792 Coenzyme A binding pocket [chemical binding]; other site 692420006793 DNA polymerase IV; Reviewed; Region: PRK03103 692420006794 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 692420006795 active site 692420006796 DNA binding site [nucleotide binding] 692420006797 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 692420006798 YolD-like protein; Region: YolD; pfam08863 692420006799 YqzH-like protein; Region: YqzH; pfam14164 692420006800 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 692420006801 Domain of unknown function DUF20; Region: UPF0118; pfam01594 692420006802 pantothenate kinase; Provisional; Region: PRK05439 692420006803 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 692420006804 ATP-binding site [chemical binding]; other site 692420006805 CoA-binding site [chemical binding]; other site 692420006806 Mg2+-binding site [ion binding]; other site 692420006807 D-serine dehydratase; Provisional; Region: PRK02991 692420006808 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 692420006809 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420006810 catalytic residue [active] 692420006811 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 692420006812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420006813 NAD(P) binding site [chemical binding]; other site 692420006814 active site 692420006815 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 692420006816 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 692420006817 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 692420006818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420006819 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 692420006820 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420006821 dimerization interface [polypeptide binding]; other site 692420006822 GlpM protein; Region: GlpM; cl01212 692420006823 potential frameshift: common BLAST hit: gi|154686643|ref|YP_001421804.1| NADPH dehydrogenase NamA 692420006824 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 692420006825 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 692420006826 phosphate binding site [ion binding]; other site 692420006827 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 692420006828 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 692420006829 ribonuclease Z; Region: RNase_Z; TIGR02651 692420006830 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 692420006831 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 692420006832 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 692420006833 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 692420006834 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 692420006835 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 692420006836 DNA polymerase IV; Validated; Region: PRK01810 692420006837 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 692420006838 active site 692420006839 DNA binding site [nucleotide binding] 692420006840 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 692420006841 OxaA-like protein precursor; Validated; Region: PRK01622 692420006842 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 692420006843 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 692420006844 peptidase T-like protein; Region: PepT-like; TIGR01883 692420006845 metal binding site [ion binding]; metal-binding site 692420006846 putative dimer interface [polypeptide binding]; other site 692420006847 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 692420006848 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 692420006849 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 692420006850 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420006851 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 692420006852 dimer interface [polypeptide binding]; other site 692420006853 substrate binding site [chemical binding]; other site 692420006854 metal binding site [ion binding]; metal-binding site 692420006855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 692420006856 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 692420006857 Predicted membrane protein [Function unknown]; Region: COG4129 692420006858 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 692420006859 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 692420006860 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 692420006861 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 692420006862 Walker A/P-loop; other site 692420006863 ATP binding site [chemical binding]; other site 692420006864 Q-loop/lid; other site 692420006865 ABC transporter signature motif; other site 692420006866 Walker B; other site 692420006867 D-loop; other site 692420006868 H-loop/switch region; other site 692420006869 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 692420006870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420006871 dimer interface [polypeptide binding]; other site 692420006872 conserved gate region; other site 692420006873 putative PBP binding loops; other site 692420006874 ABC-ATPase subunit interface; other site 692420006875 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420006876 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 692420006877 substrate binding pocket [chemical binding]; other site 692420006878 membrane-bound complex binding site; other site 692420006879 hinge residues; other site 692420006880 Disulphide isomerase; Region: Disulph_isomer; pfam06491 692420006881 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 692420006882 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 692420006883 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 692420006884 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 692420006885 E3 interaction surface; other site 692420006886 lipoyl attachment site [posttranslational modification]; other site 692420006887 e3 binding domain; Region: E3_binding; pfam02817 692420006888 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 692420006889 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 692420006890 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 692420006891 alpha subunit interface [polypeptide binding]; other site 692420006892 TPP binding site [chemical binding]; other site 692420006893 heterodimer interface [polypeptide binding]; other site 692420006894 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 692420006895 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 692420006896 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 692420006897 tetramer interface [polypeptide binding]; other site 692420006898 TPP-binding site [chemical binding]; other site 692420006899 heterodimer interface [polypeptide binding]; other site 692420006900 phosphorylation loop region [posttranslational modification] 692420006901 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 692420006902 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 692420006903 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420006904 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 692420006905 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 692420006906 nucleotide binding site [chemical binding]; other site 692420006907 Acetokinase family; Region: Acetate_kinase; cl17229 692420006908 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 692420006909 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 692420006910 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 692420006911 NAD binding site [chemical binding]; other site 692420006912 Phe binding site; other site 692420006913 phosphate butyryltransferase; Validated; Region: PRK07742 692420006914 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 692420006915 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 692420006916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420006917 putative active site [active] 692420006918 heme pocket [chemical binding]; other site 692420006919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420006920 putative active site [active] 692420006921 heme pocket [chemical binding]; other site 692420006922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420006923 Walker A motif; other site 692420006924 ATP binding site [chemical binding]; other site 692420006925 Walker B motif; other site 692420006926 arginine finger; other site 692420006927 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 692420006928 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 692420006929 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 692420006930 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 692420006931 tetramer interface [polypeptide binding]; other site 692420006932 active site 692420006933 Mg2+/Mn2+ binding site [ion binding]; other site 692420006934 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 692420006935 2-methylcitrate dehydratase; Region: prpD; TIGR02330 692420006936 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 692420006937 dimer interface [polypeptide binding]; other site 692420006938 Citrate synthase; Region: Citrate_synt; pfam00285 692420006939 active site 692420006940 coenzyme A binding site [chemical binding]; other site 692420006941 citrylCoA binding site [chemical binding]; other site 692420006942 oxalacetate/citrate binding site [chemical binding]; other site 692420006943 catalytic triad [active] 692420006944 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 692420006945 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 692420006946 FAD binding site [chemical binding]; other site 692420006947 homotetramer interface [polypeptide binding]; other site 692420006948 substrate binding pocket [chemical binding]; other site 692420006949 catalytic base [active] 692420006950 potential frameshift: common BLAST hit: gi|154686675|ref|YP_001421836.1| MmgB 692420006951 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 692420006952 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 692420006953 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 692420006954 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 692420006955 dimer interface [polypeptide binding]; other site 692420006956 active site 692420006957 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 692420006958 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 692420006959 active site 692420006960 catalytic site [active] 692420006961 metal binding site [ion binding]; metal-binding site 692420006962 dimer interface [polypeptide binding]; other site 692420006963 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 692420006964 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 692420006965 active site 692420006966 metal binding site [ion binding]; metal-binding site 692420006967 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 692420006968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420006969 sequence-specific DNA binding site [nucleotide binding]; other site 692420006970 salt bridge; other site 692420006971 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 692420006972 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 692420006973 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 692420006974 putative active site [active] 692420006975 putative FMN binding site [chemical binding]; other site 692420006976 putative substrate binding site [chemical binding]; other site 692420006977 putative catalytic residue [active] 692420006978 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420006979 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420006980 alanine racemase; Region: alr; TIGR00492 692420006981 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 692420006982 active site 692420006983 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 692420006984 dimer interface [polypeptide binding]; other site 692420006985 substrate binding site [chemical binding]; other site 692420006986 catalytic residues [active] 692420006987 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 692420006988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420006989 active site 692420006990 phosphorylation site [posttranslational modification] 692420006991 intermolecular recognition site; other site 692420006992 dimerization interface [polypeptide binding]; other site 692420006993 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 692420006994 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 692420006995 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 692420006996 protein binding site [polypeptide binding]; other site 692420006997 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 692420006998 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 692420006999 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 692420007000 Walker A/P-loop; other site 692420007001 ATP binding site [chemical binding]; other site 692420007002 Q-loop/lid; other site 692420007003 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 692420007004 ABC transporter signature motif; other site 692420007005 Walker B; other site 692420007006 D-loop; other site 692420007007 H-loop/switch region; other site 692420007008 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 692420007009 arginine repressor; Provisional; Region: PRK04280 692420007010 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 692420007011 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 692420007012 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420007013 RNA binding surface [nucleotide binding]; other site 692420007014 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 692420007015 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 692420007016 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 692420007017 TPP-binding site; other site 692420007018 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 692420007019 PYR/PP interface [polypeptide binding]; other site 692420007020 dimer interface [polypeptide binding]; other site 692420007021 TPP binding site [chemical binding]; other site 692420007022 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 692420007023 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 692420007024 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 692420007025 substrate binding pocket [chemical binding]; other site 692420007026 chain length determination region; other site 692420007027 substrate-Mg2+ binding site; other site 692420007028 catalytic residues [active] 692420007029 aspartate-rich region 1; other site 692420007030 active site lid residues [active] 692420007031 aspartate-rich region 2; other site 692420007032 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 692420007033 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 692420007034 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 692420007035 generic binding surface II; other site 692420007036 generic binding surface I; other site 692420007037 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 692420007038 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 692420007039 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 692420007040 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 692420007041 homodimer interface [polypeptide binding]; other site 692420007042 NADP binding site [chemical binding]; other site 692420007043 substrate binding site [chemical binding]; other site 692420007044 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 692420007045 putative RNA binding site [nucleotide binding]; other site 692420007046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 692420007047 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 692420007048 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 692420007049 ATP-grasp domain; Region: ATP-grasp_4; cl17255 692420007050 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 692420007051 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 692420007052 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 692420007053 carboxyltransferase (CT) interaction site; other site 692420007054 biotinylation site [posttranslational modification]; other site 692420007055 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 692420007056 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 692420007057 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 692420007058 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 692420007059 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 692420007060 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 692420007061 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 692420007062 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 692420007063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420007064 Walker A motif; other site 692420007065 ATP binding site [chemical binding]; other site 692420007066 Walker B motif; other site 692420007067 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 692420007068 elongation factor P; Validated; Region: PRK00529 692420007069 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 692420007070 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 692420007071 RNA binding site [nucleotide binding]; other site 692420007072 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 692420007073 RNA binding site [nucleotide binding]; other site 692420007074 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 692420007075 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 692420007076 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 692420007077 active site 692420007078 Conserved membrane protein YqhR; Region: YqhR; pfam11085 692420007079 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 692420007080 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 692420007081 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 692420007082 active site 692420007083 nucleophile elbow; other site 692420007084 manganese transport transcriptional regulator; Provisional; Region: PRK03902 692420007085 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 692420007086 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 692420007087 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 692420007088 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 692420007089 active site residue [active] 692420007090 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 692420007091 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 692420007092 tetramer interface [polypeptide binding]; other site 692420007093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420007094 catalytic residue [active] 692420007095 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 692420007096 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 692420007097 tetramer interface [polypeptide binding]; other site 692420007098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420007099 catalytic residue [active] 692420007100 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 692420007101 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 692420007102 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 692420007103 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 692420007104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420007105 ATP binding site [chemical binding]; other site 692420007106 putative Mg++ binding site [ion binding]; other site 692420007107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420007108 nucleotide binding region [chemical binding]; other site 692420007109 ATP-binding site [chemical binding]; other site 692420007110 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 692420007111 Anti-repressor SinI; Region: SinI; pfam08671 692420007112 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420007113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420007114 non-specific DNA binding site [nucleotide binding]; other site 692420007115 salt bridge; other site 692420007116 sequence-specific DNA binding site [nucleotide binding]; other site 692420007117 Anti-repressor SinI; Region: SinI; pfam08671 692420007118 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 692420007119 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 692420007120 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 692420007121 Catalytic site [active] 692420007122 YqxM protein; Region: YqxM_for_SipW; TIGR04087 692420007123 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 692420007124 YqzE-like protein; Region: YqzE; pfam14038 692420007125 ComG operon protein 7; Region: ComGG; pfam14173 692420007126 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 692420007127 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 692420007128 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 692420007129 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 692420007130 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 692420007131 Type II/IV secretion system protein; Region: T2SE; pfam00437 692420007132 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 692420007133 Walker A motif; other site 692420007134 ATP binding site [chemical binding]; other site 692420007135 Walker B motif; other site 692420007136 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 692420007137 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 692420007138 Cl binding site [ion binding]; other site 692420007139 oligomer interface [polypeptide binding]; other site 692420007140 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 692420007141 Domain of unknown function DUF21; Region: DUF21; pfam01595 692420007142 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 692420007143 Transporter associated domain; Region: CorC_HlyC; smart01091 692420007144 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420007145 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 692420007146 ArsC family; Region: ArsC; pfam03960 692420007147 putative catalytic residues [active] 692420007148 thiol/disulfide switch; other site 692420007149 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 692420007150 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 692420007151 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 692420007152 Uncharacterized conserved protein [Function unknown]; Region: COG0011 692420007153 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 692420007154 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 692420007155 putative active site [active] 692420007156 Zn binding site [ion binding]; other site 692420007157 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 692420007158 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 692420007159 nucleotide binding site [chemical binding]; other site 692420007160 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 692420007161 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 692420007162 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 692420007163 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 692420007164 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 692420007165 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 692420007166 YceG-like family; Region: YceG; pfam02618 692420007167 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 692420007168 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 692420007169 Walker A/P-loop; other site 692420007170 ATP binding site [chemical binding]; other site 692420007171 Q-loop/lid; other site 692420007172 ABC transporter signature motif; other site 692420007173 Walker B; other site 692420007174 D-loop; other site 692420007175 H-loop/switch region; other site 692420007176 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 692420007177 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 692420007178 Walker A/P-loop; other site 692420007179 ATP binding site [chemical binding]; other site 692420007180 Q-loop/lid; other site 692420007181 ABC transporter signature motif; other site 692420007182 Walker B; other site 692420007183 D-loop; other site 692420007184 H-loop/switch region; other site 692420007185 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 692420007186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420007187 dimer interface [polypeptide binding]; other site 692420007188 conserved gate region; other site 692420007189 ABC-ATPase subunit interface; other site 692420007190 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 692420007191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420007192 dimer interface [polypeptide binding]; other site 692420007193 conserved gate region; other site 692420007194 putative PBP binding loops; other site 692420007195 ABC-ATPase subunit interface; other site 692420007196 PBP superfamily domain; Region: PBP_like_2; cl17296 692420007197 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 692420007198 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 692420007199 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420007200 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 692420007201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420007202 putative substrate translocation pore; other site 692420007203 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420007204 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 692420007205 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 692420007206 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 692420007207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 692420007208 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 692420007209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 692420007210 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 692420007211 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 692420007212 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 692420007213 Uncharacterized conserved protein [Function unknown]; Region: COG5663 692420007214 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 692420007215 metal binding site 2 [ion binding]; metal-binding site 692420007216 putative DNA binding helix; other site 692420007217 metal binding site 1 [ion binding]; metal-binding site 692420007218 dimer interface [polypeptide binding]; other site 692420007219 structural Zn2+ binding site [ion binding]; other site 692420007220 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420007221 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420007222 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420007223 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 692420007224 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 692420007225 endonuclease IV; Provisional; Region: PRK01060 692420007226 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 692420007227 AP (apurinic/apyrimidinic) site pocket; other site 692420007228 DNA interaction; other site 692420007229 Metal-binding active site; metal-binding site 692420007230 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 692420007231 DEAD-like helicases superfamily; Region: DEXDc; smart00487 692420007232 ATP binding site [chemical binding]; other site 692420007233 Mg++ binding site [ion binding]; other site 692420007234 motif III; other site 692420007235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420007236 nucleotide binding region [chemical binding]; other site 692420007237 ATP-binding site [chemical binding]; other site 692420007238 YqfQ-like protein; Region: YqfQ; pfam14181 692420007239 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 692420007240 LytB protein; Region: LYTB; pfam02401 692420007241 Uncharacterized conserved protein [Function unknown]; Region: COG0327 692420007242 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 692420007243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 692420007244 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 692420007245 Uncharacterized conserved protein [Function unknown]; Region: COG0327 692420007246 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 692420007247 Family of unknown function (DUF633); Region: DUF633; pfam04816 692420007248 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 692420007249 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 692420007250 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 692420007251 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 692420007252 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 692420007253 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420007254 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 692420007255 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420007256 DNA binding residues [nucleotide binding] 692420007257 DNA primase; Validated; Region: dnaG; PRK05667 692420007258 CHC2 zinc finger; Region: zf-CHC2; pfam01807 692420007259 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 692420007260 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 692420007261 active site 692420007262 metal binding site [ion binding]; metal-binding site 692420007263 interdomain interaction site; other site 692420007264 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 692420007265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 692420007266 PEP synthetase regulatory protein; Provisional; Region: PRK05339 692420007267 HTH domain; Region: HTH_11; pfam08279 692420007268 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 692420007269 FOG: CBS domain [General function prediction only]; Region: COG0517 692420007270 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 692420007271 DALR anticodon binding domain; Region: DALR_1; pfam05746 692420007272 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 692420007273 dimer interface [polypeptide binding]; other site 692420007274 motif 1; other site 692420007275 active site 692420007276 motif 2; other site 692420007277 motif 3; other site 692420007278 Recombination protein O N terminal; Region: RecO_N; pfam11967 692420007279 DNA repair protein RecO; Region: reco; TIGR00613 692420007280 Recombination protein O C terminal; Region: RecO_C; pfam02565 692420007281 GTPase Era; Reviewed; Region: era; PRK00089 692420007282 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 692420007283 G1 box; other site 692420007284 GTP/Mg2+ binding site [chemical binding]; other site 692420007285 Switch I region; other site 692420007286 G2 box; other site 692420007287 Switch II region; other site 692420007288 G3 box; other site 692420007289 G4 box; other site 692420007290 G5 box; other site 692420007291 KH domain; Region: KH_2; pfam07650 692420007292 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 692420007293 active site 692420007294 catalytic motif [active] 692420007295 Zn binding site [ion binding]; other site 692420007296 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 692420007297 metal-binding heat shock protein; Provisional; Region: PRK00016 692420007298 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 692420007299 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 692420007300 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 692420007301 Zn2+ binding site [ion binding]; other site 692420007302 Mg2+ binding site [ion binding]; other site 692420007303 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 692420007304 PhoH-like protein; Region: PhoH; pfam02562 692420007305 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 692420007306 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 692420007307 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 692420007308 hypothetical protein; Provisional; Region: PRK13665 692420007309 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 692420007310 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 692420007311 dimer interface [polypeptide binding]; other site 692420007312 active site residues [active] 692420007313 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 692420007314 Yqey-like protein; Region: YqeY; pfam09424 692420007315 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 692420007316 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 692420007317 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 692420007318 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 692420007319 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 692420007320 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 692420007321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420007322 FeS/SAM binding site; other site 692420007323 TRAM domain; Region: TRAM; cl01282 692420007324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 692420007325 RNA methyltransferase, RsmE family; Region: TIGR00046 692420007326 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 692420007327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420007328 S-adenosylmethionine binding site [chemical binding]; other site 692420007329 chaperone protein DnaJ; Provisional; Region: PRK14280 692420007330 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 692420007331 HSP70 interaction site [polypeptide binding]; other site 692420007332 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 692420007333 substrate binding site [polypeptide binding]; other site 692420007334 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 692420007335 Zn binding sites [ion binding]; other site 692420007336 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 692420007337 dimer interface [polypeptide binding]; other site 692420007338 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 692420007339 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 692420007340 nucleotide binding site [chemical binding]; other site 692420007341 NEF interaction site [polypeptide binding]; other site 692420007342 SBD interface [polypeptide binding]; other site 692420007343 GrpE; Region: GrpE; pfam01025 692420007344 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 692420007345 dimer interface [polypeptide binding]; other site 692420007346 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 692420007347 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 692420007348 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 692420007349 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 692420007350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420007351 FeS/SAM binding site; other site 692420007352 HemN C-terminal domain; Region: HemN_C; pfam06969 692420007353 GTP-binding protein LepA; Provisional; Region: PRK05433 692420007354 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 692420007355 G1 box; other site 692420007356 putative GEF interaction site [polypeptide binding]; other site 692420007357 GTP/Mg2+ binding site [chemical binding]; other site 692420007358 Switch I region; other site 692420007359 G2 box; other site 692420007360 G3 box; other site 692420007361 Switch II region; other site 692420007362 G4 box; other site 692420007363 G5 box; other site 692420007364 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 692420007365 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 692420007366 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 692420007367 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 692420007368 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 692420007369 stage II sporulation protein P; Region: spore_II_P; TIGR02867 692420007370 germination protease; Provisional; Region: PRK02858 692420007371 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 692420007372 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 692420007373 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 692420007374 YqzM-like protein; Region: YqzM; pfam14141 692420007375 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 692420007376 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 692420007377 Competence protein; Region: Competence; pfam03772 692420007378 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 692420007379 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 692420007380 catalytic motif [active] 692420007381 Zn binding site [ion binding]; other site 692420007382 SLBB domain; Region: SLBB; pfam10531 692420007383 comEA protein; Region: comE; TIGR01259 692420007384 Helix-hairpin-helix motif; Region: HHH; pfam00633 692420007385 late competence protein ComER; Validated; Region: PRK07680 692420007386 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 692420007387 Methyltransferase domain; Region: Methyltransf_31; pfam13847 692420007388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420007389 S-adenosylmethionine binding site [chemical binding]; other site 692420007390 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 692420007391 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 692420007392 Zn2+ binding site [ion binding]; other site 692420007393 Mg2+ binding site [ion binding]; other site 692420007394 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 692420007395 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 692420007396 active site 692420007397 (T/H)XGH motif; other site 692420007398 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 692420007399 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 692420007400 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 692420007401 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 692420007402 shikimate binding site; other site 692420007403 NAD(P) binding site [chemical binding]; other site 692420007404 GTPase YqeH; Provisional; Region: PRK13796 692420007405 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 692420007406 GTP/Mg2+ binding site [chemical binding]; other site 692420007407 G4 box; other site 692420007408 G5 box; other site 692420007409 G1 box; other site 692420007410 Switch I region; other site 692420007411 G2 box; other site 692420007412 G3 box; other site 692420007413 Switch II region; other site 692420007414 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 692420007415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420007416 active site 692420007417 motif I; other site 692420007418 motif II; other site 692420007419 Sporulation inhibitor A; Region: Sda; pfam08970 692420007420 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 692420007421 active site 692420007422 catalytic triad [active] 692420007423 oxyanion hole [active] 692420007424 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 692420007425 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 692420007426 Uncharacterized conserved protein [Function unknown]; Region: COG0398 692420007427 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 692420007428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420007429 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420007430 putative substrate translocation pore; other site 692420007431 sporulation sigma factor SigK; Reviewed; Region: PRK05803 692420007432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 692420007433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420007434 DNA binding residues [nucleotide binding] 692420007435 Resolvase, N terminal domain; Region: Resolvase; smart00857 692420007436 catalytic residues [active] 692420007437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420007438 AAA domain; Region: AAA_23; pfam13476 692420007439 Walker A/P-loop; other site 692420007440 ATP binding site [chemical binding]; other site 692420007441 AAA domain; Region: AAA_21; pfam13304 692420007442 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 692420007443 putative active site [active] 692420007444 putative metal-binding site [ion binding]; other site 692420007445 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 692420007446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420007447 NAD(P) binding site [chemical binding]; other site 692420007448 active site 692420007449 peptide synthase; Provisional; Region: PRK12316 692420007450 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 692420007451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420007452 putative substrate translocation pore; other site 692420007453 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 692420007454 Glutamine amidotransferase class-I; Region: GATase; pfam00117 692420007455 glutamine binding [chemical binding]; other site 692420007456 catalytic triad [active] 692420007457 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 692420007458 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 692420007459 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 692420007460 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 692420007461 acyl-activating enzyme (AAE) consensus motif; other site 692420007462 AMP binding site [chemical binding]; other site 692420007463 active site 692420007464 CoA binding site [chemical binding]; other site 692420007465 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420007466 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 692420007467 acyl-activating enzyme (AAE) consensus motif; other site 692420007468 AMP binding site [chemical binding]; other site 692420007469 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420007470 Condensation domain; Region: Condensation; pfam00668 692420007471 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 692420007472 Nonribosomal peptide synthase; Region: NRPS; pfam08415 692420007473 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 692420007474 acyl-activating enzyme (AAE) consensus motif; other site 692420007475 AMP binding site [chemical binding]; other site 692420007476 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420007477 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 692420007478 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 692420007479 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 692420007480 dimer interface [polypeptide binding]; other site 692420007481 active site 692420007482 glycine-pyridoxal phosphate binding site [chemical binding]; other site 692420007483 folate binding site [chemical binding]; other site 692420007484 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420007485 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 692420007486 Predicted transcriptional regulator [Transcription]; Region: COG2378 692420007487 HTH domain; Region: HTH_11; pfam08279 692420007488 WYL domain; Region: WYL; pfam13280 692420007489 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 692420007490 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 692420007491 conserved cys residue [active] 692420007492 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 692420007493 similar to spoIIIC## fragment 692420007494 similar to hypothetical protein 692420007495 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 692420007496 aspartate racemase; Region: asp_race; TIGR00035 692420007497 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 692420007498 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420007499 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420007500 active site 692420007501 catalytic tetrad [active] 692420007502 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 692420007503 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 692420007504 DNA binding residues [nucleotide binding] 692420007505 putative dimer interface [polypeptide binding]; other site 692420007506 RecT family; Region: RecT; cl04285 692420007507 Domain of unknown function (DUF303); Region: DUF303; pfam03629 692420007508 potential frameshift: common BLAST hit: gi|150391618|ref|YP_001321667.1| PadR-like family transcriptional regulator 692420007509 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 692420007510 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 692420007511 hypothetical protein; Validated; Region: PRK06217 692420007512 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 692420007513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420007514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420007515 putative substrate translocation pore; other site 692420007516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420007517 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 692420007518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420007519 Coenzyme A binding pocket [chemical binding]; other site 692420007520 DinB family; Region: DinB; pfam05163 692420007521 DinB superfamily; Region: DinB_2; pfam12867 692420007522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 692420007523 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 692420007524 active site 692420007525 motif I; other site 692420007526 motif II; other site 692420007527 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 692420007528 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 692420007529 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 692420007530 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 692420007531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420007532 active site 692420007533 motif I; other site 692420007534 motif II; other site 692420007535 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 692420007536 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 692420007537 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 692420007538 putative active site [active] 692420007539 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 692420007540 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 692420007541 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 692420007542 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 692420007543 active site 692420007544 P-loop; other site 692420007545 phosphorylation site [posttranslational modification] 692420007546 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 692420007547 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 692420007548 active site 692420007549 phosphorylation site [posttranslational modification] 692420007550 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 692420007551 HTH domain; Region: HTH_11; cl17392 692420007552 Mga helix-turn-helix domain; Region: Mga; pfam05043 692420007553 PRD domain; Region: PRD; pfam00874 692420007554 PRD domain; Region: PRD; pfam00874 692420007555 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 692420007556 active site 692420007557 P-loop; other site 692420007558 phosphorylation site [posttranslational modification] 692420007559 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 692420007560 active site 692420007561 phosphorylation site [posttranslational modification] 692420007562 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 692420007563 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 692420007564 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 692420007565 putative deacylase active site [active] 692420007566 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420007567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 692420007568 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 692420007569 putative dimerization interface [polypeptide binding]; other site 692420007570 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420007571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420007572 putative substrate translocation pore; other site 692420007573 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 692420007574 Cytochrome P450; Region: p450; pfam00067 692420007575 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 692420007576 Flavodoxin; Region: Flavodoxin_1; pfam00258 692420007577 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 692420007578 FAD binding pocket [chemical binding]; other site 692420007579 FAD binding motif [chemical binding]; other site 692420007580 catalytic residues [active] 692420007581 NAD binding pocket [chemical binding]; other site 692420007582 phosphate binding motif [ion binding]; other site 692420007583 beta-alpha-beta structure motif; other site 692420007584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420007585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420007586 Methyltransferase domain; Region: Methyltransf_11; pfam08241 692420007587 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 692420007588 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 692420007589 Uncharacterized conserved protein [Function unknown]; Region: COG5609 692420007590 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 692420007591 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 692420007592 catalytic loop [active] 692420007593 iron binding site [ion binding]; other site 692420007594 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 692420007595 4Fe-4S binding domain; Region: Fer4; pfam00037 692420007596 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 692420007597 [4Fe-4S] binding site [ion binding]; other site 692420007598 molybdopterin cofactor binding site; other site 692420007599 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 692420007600 molybdopterin cofactor binding site; other site 692420007601 Uncharacterized conserved protein [Function unknown]; Region: COG2427 692420007602 YrhC-like protein; Region: YrhC; pfam14143 692420007603 cystathionine beta-lyase; Provisional; Region: PRK07671 692420007604 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 692420007605 homodimer interface [polypeptide binding]; other site 692420007606 substrate-cofactor binding pocket; other site 692420007607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420007608 catalytic residue [active] 692420007609 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 692420007610 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 692420007611 dimer interface [polypeptide binding]; other site 692420007612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420007613 catalytic residue [active] 692420007614 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 692420007615 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 692420007616 Methyltransferase domain; Region: Methyltransf_11; pfam08241 692420007617 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 692420007618 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 692420007619 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 692420007620 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 692420007621 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 692420007622 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 692420007623 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 692420007624 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 692420007625 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 692420007626 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 692420007627 ATP-binding site [chemical binding]; other site 692420007628 Sugar specificity; other site 692420007629 Pyrimidine base specificity; other site 692420007630 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 692420007631 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 692420007632 Peptidase family U32; Region: Peptidase_U32; pfam01136 692420007633 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 692420007634 Peptidase family U32; Region: Peptidase_U32; pfam01136 692420007635 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 692420007636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420007637 S-adenosylmethionine binding site [chemical binding]; other site 692420007638 conserved hypothetical protein, YceG family; Region: TIGR00247 692420007639 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 692420007640 dimerization interface [polypeptide binding]; other site 692420007641 hypothetical protein; Provisional; Region: PRK13678 692420007642 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 692420007643 hypothetical protein; Provisional; Region: PRK05473 692420007644 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 692420007645 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 692420007646 motif 1; other site 692420007647 active site 692420007648 motif 2; other site 692420007649 motif 3; other site 692420007650 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 692420007651 DHHA1 domain; Region: DHHA1; pfam02272 692420007652 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 692420007653 Domain of unknown function DUF20; Region: UPF0118; pfam01594 692420007654 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 692420007655 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 692420007656 Walker A/P-loop; other site 692420007657 ATP binding site [chemical binding]; other site 692420007658 Q-loop/lid; other site 692420007659 ABC transporter signature motif; other site 692420007660 Walker B; other site 692420007661 D-loop; other site 692420007662 H-loop/switch region; other site 692420007663 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 692420007664 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420007665 substrate binding pocket [chemical binding]; other site 692420007666 membrane-bound complex binding site; other site 692420007667 hinge residues; other site 692420007668 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 692420007669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420007670 dimer interface [polypeptide binding]; other site 692420007671 conserved gate region; other site 692420007672 putative PBP binding loops; other site 692420007673 ABC-ATPase subunit interface; other site 692420007674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420007675 dimer interface [polypeptide binding]; other site 692420007676 conserved gate region; other site 692420007677 putative PBP binding loops; other site 692420007678 ABC-ATPase subunit interface; other site 692420007679 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 692420007680 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 692420007681 AAA domain; Region: AAA_30; pfam13604 692420007682 Family description; Region: UvrD_C_2; pfam13538 692420007683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420007684 binding surface 692420007685 TPR repeat; Region: TPR_11; pfam13414 692420007686 TPR motif; other site 692420007687 TPR repeat; Region: TPR_11; pfam13414 692420007688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420007689 binding surface 692420007690 TPR motif; other site 692420007691 TPR repeat; Region: TPR_11; pfam13414 692420007692 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 692420007693 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 692420007694 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 692420007695 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 692420007696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420007697 catalytic residue [active] 692420007698 Predicted transcriptional regulator [Transcription]; Region: COG1959 692420007699 Transcriptional regulator; Region: Rrf2; pfam02082 692420007700 recombination factor protein RarA; Reviewed; Region: PRK13342 692420007701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420007702 Walker A motif; other site 692420007703 ATP binding site [chemical binding]; other site 692420007704 Walker B motif; other site 692420007705 arginine finger; other site 692420007706 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 692420007707 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 692420007708 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 692420007709 putative ATP binding site [chemical binding]; other site 692420007710 putative substrate interface [chemical binding]; other site 692420007711 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 692420007712 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 692420007713 dimer interface [polypeptide binding]; other site 692420007714 anticodon binding site; other site 692420007715 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 692420007716 homodimer interface [polypeptide binding]; other site 692420007717 motif 1; other site 692420007718 active site 692420007719 motif 2; other site 692420007720 GAD domain; Region: GAD; pfam02938 692420007721 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 692420007722 active site 692420007723 motif 3; other site 692420007724 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 692420007725 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 692420007726 dimer interface [polypeptide binding]; other site 692420007727 motif 1; other site 692420007728 active site 692420007729 motif 2; other site 692420007730 motif 3; other site 692420007731 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 692420007732 anticodon binding site; other site 692420007733 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 692420007734 Bacterial SH3 domain; Region: SH3_3; pfam08239 692420007735 Bacterial SH3 domain; Region: SH3_3; pfam08239 692420007736 Bacterial SH3 domain; Region: SH3_3; pfam08239 692420007737 Bacterial SH3 domain homologues; Region: SH3b; smart00287 692420007738 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 692420007739 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 692420007740 active site 692420007741 metal binding site [ion binding]; metal-binding site 692420007742 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 692420007743 putative active site [active] 692420007744 dimerization interface [polypeptide binding]; other site 692420007745 putative tRNAtyr binding site [nucleotide binding]; other site 692420007746 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 692420007747 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 692420007748 Zn2+ binding site [ion binding]; other site 692420007749 Mg2+ binding site [ion binding]; other site 692420007750 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 692420007751 synthetase active site [active] 692420007752 NTP binding site [chemical binding]; other site 692420007753 metal binding site [ion binding]; metal-binding site 692420007754 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 692420007755 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 692420007756 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420007757 active site 692420007758 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 692420007759 DHH family; Region: DHH; pfam01368 692420007760 DHHA1 domain; Region: DHHA1; pfam02272 692420007761 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 692420007762 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 692420007763 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 692420007764 TrkA-C domain; Region: TrkA_C; pfam02080 692420007765 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 692420007766 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 692420007767 Protein export membrane protein; Region: SecD_SecF; pfam02355 692420007768 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 692420007769 stage V sporulation protein B; Region: spore_V_B; TIGR02900 692420007770 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 692420007771 Predicted membrane protein [Function unknown]; Region: COG2323 692420007772 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 692420007773 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 692420007774 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 692420007775 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 692420007776 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 692420007777 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 692420007778 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 692420007779 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 692420007780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420007781 Walker A motif; other site 692420007782 ATP binding site [chemical binding]; other site 692420007783 Walker B motif; other site 692420007784 arginine finger; other site 692420007785 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 692420007786 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 692420007787 RuvA N terminal domain; Region: RuvA_N; pfam01330 692420007788 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 692420007789 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 692420007790 BofC C-terminal domain; Region: BofC_C; pfam08955 692420007791 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 692420007792 similar to fragment spore cortex protein B. subtilis 692420007793 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 692420007794 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420007795 quinolinate synthetase; Provisional; Region: PRK09375 692420007796 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 692420007797 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 692420007798 dimerization interface [polypeptide binding]; other site 692420007799 active site 692420007800 L-aspartate oxidase; Provisional; Region: PRK08071 692420007801 L-aspartate oxidase; Provisional; Region: PRK06175 692420007802 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 692420007803 cysteine desulfurase; Provisional; Region: PRK02948 692420007804 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 692420007805 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420007806 catalytic residue [active] 692420007807 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 692420007808 HTH domain; Region: HTH_11; pfam08279 692420007809 3H domain; Region: 3H; pfam02829 692420007810 prephenate dehydratase; Provisional; Region: PRK11898 692420007811 Prephenate dehydratase; Region: PDT; pfam00800 692420007812 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 692420007813 putative L-Phe binding site [chemical binding]; other site 692420007814 hypothetical protein; Provisional; Region: PRK04435 692420007815 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 692420007816 GTPase CgtA; Reviewed; Region: obgE; PRK12297 692420007817 GTP1/OBG; Region: GTP1_OBG; pfam01018 692420007818 Obg GTPase; Region: Obg; cd01898 692420007819 G1 box; other site 692420007820 GTP/Mg2+ binding site [chemical binding]; other site 692420007821 Switch I region; other site 692420007822 G2 box; other site 692420007823 G3 box; other site 692420007824 Switch II region; other site 692420007825 G4 box; other site 692420007826 G5 box; other site 692420007827 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 692420007828 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 692420007829 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 692420007830 hypothetical protein; Provisional; Region: PRK14553 692420007831 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 692420007832 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 692420007833 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 692420007834 Peptidase family M50; Region: Peptidase_M50; pfam02163 692420007835 active site 692420007836 putative substrate binding region [chemical binding]; other site 692420007837 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 692420007838 Peptidase family M23; Region: Peptidase_M23; pfam01551 692420007839 septum site-determining protein MinD; Region: minD_bact; TIGR01968 692420007840 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 692420007841 Switch I; other site 692420007842 Switch II; other site 692420007843 septum formation inhibitor; Reviewed; Region: minC; PRK00513 692420007844 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 692420007845 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 692420007846 rod shape-determining protein MreC; Region: mreC; TIGR00219 692420007847 rod shape-determining protein MreC; Region: MreC; pfam04085 692420007848 rod shape-determining protein MreB; Provisional; Region: PRK13927 692420007849 MreB and similar proteins; Region: MreB_like; cd10225 692420007850 nucleotide binding site [chemical binding]; other site 692420007851 Mg binding site [ion binding]; other site 692420007852 putative protofilament interaction site [polypeptide binding]; other site 692420007853 RodZ interaction site [polypeptide binding]; other site 692420007854 hypothetical protein; Reviewed; Region: PRK00024 692420007855 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 692420007856 MPN+ (JAMM) motif; other site 692420007857 Zinc-binding site [ion binding]; other site 692420007858 Maf-like protein; Region: Maf; pfam02545 692420007859 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 692420007860 active site 692420007861 dimer interface [polypeptide binding]; other site 692420007862 Sporulation related domain; Region: SPOR; pfam05036 692420007863 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 692420007864 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 692420007865 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 692420007866 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 692420007867 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 692420007868 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 692420007869 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 692420007870 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 692420007871 active site 692420007872 HIGH motif; other site 692420007873 nucleotide binding site [chemical binding]; other site 692420007874 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 692420007875 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 692420007876 active site 692420007877 KMSKS motif; other site 692420007878 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 692420007879 tRNA binding surface [nucleotide binding]; other site 692420007880 anticodon binding site; other site 692420007881 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 692420007882 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 692420007883 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 692420007884 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 692420007885 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 692420007886 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 692420007887 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420007888 inhibitor-cofactor binding pocket; inhibition site 692420007889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420007890 catalytic residue [active] 692420007891 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 692420007892 dimer interface [polypeptide binding]; other site 692420007893 active site 692420007894 Schiff base residues; other site 692420007895 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 692420007896 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 692420007897 active site 692420007898 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 692420007899 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 692420007900 domain interfaces; other site 692420007901 active site 692420007902 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 692420007903 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 692420007904 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 692420007905 tRNA; other site 692420007906 putative tRNA binding site [nucleotide binding]; other site 692420007907 putative NADP binding site [chemical binding]; other site 692420007908 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 692420007909 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 692420007910 G1 box; other site 692420007911 GTP/Mg2+ binding site [chemical binding]; other site 692420007912 Switch I region; other site 692420007913 G2 box; other site 692420007914 G3 box; other site 692420007915 Switch II region; other site 692420007916 G4 box; other site 692420007917 G5 box; other site 692420007918 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 692420007919 Found in ATP-dependent protease La (LON); Region: LON; smart00464 692420007920 Found in ATP-dependent protease La (LON); Region: LON; smart00464 692420007921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420007922 Walker A motif; other site 692420007923 ATP binding site [chemical binding]; other site 692420007924 Walker B motif; other site 692420007925 arginine finger; other site 692420007926 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 692420007927 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 692420007928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420007929 Walker A motif; other site 692420007930 ATP binding site [chemical binding]; other site 692420007931 Walker B motif; other site 692420007932 arginine finger; other site 692420007933 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 692420007934 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 692420007935 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 692420007936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420007937 Walker A motif; other site 692420007938 ATP binding site [chemical binding]; other site 692420007939 Walker B motif; other site 692420007940 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 692420007941 trigger factor; Provisional; Region: tig; PRK01490 692420007942 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 692420007943 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 692420007944 TPR repeat; Region: TPR_11; pfam13414 692420007945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420007946 binding surface 692420007947 TPR motif; other site 692420007948 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 692420007949 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 692420007950 substrate binding site [chemical binding]; other site 692420007951 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 692420007952 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 692420007953 substrate binding site [chemical binding]; other site 692420007954 ligand binding site [chemical binding]; other site 692420007955 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 692420007956 tartrate dehydrogenase; Region: TTC; TIGR02089 692420007957 2-isopropylmalate synthase; Validated; Region: PRK00915 692420007958 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 692420007959 active site 692420007960 catalytic residues [active] 692420007961 metal binding site [ion binding]; metal-binding site 692420007962 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 692420007963 ketol-acid reductoisomerase; Provisional; Region: PRK05479 692420007964 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 692420007965 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 692420007966 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 692420007967 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 692420007968 putative valine binding site [chemical binding]; other site 692420007969 dimer interface [polypeptide binding]; other site 692420007970 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 692420007971 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 692420007972 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 692420007973 PYR/PP interface [polypeptide binding]; other site 692420007974 dimer interface [polypeptide binding]; other site 692420007975 TPP binding site [chemical binding]; other site 692420007976 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 692420007977 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 692420007978 TPP-binding site [chemical binding]; other site 692420007979 dimer interface [polypeptide binding]; other site 692420007980 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 692420007981 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 692420007982 active site 692420007983 metal binding site [ion binding]; metal-binding site 692420007984 homotetramer interface [polypeptide binding]; other site 692420007985 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 692420007986 active site 692420007987 dimerization interface [polypeptide binding]; other site 692420007988 ribonuclease PH; Reviewed; Region: rph; PRK00173 692420007989 Ribonuclease PH; Region: RNase_PH_bact; cd11362 692420007990 hexamer interface [polypeptide binding]; other site 692420007991 active site 692420007992 Sporulation and spore germination; Region: Germane; pfam10646 692420007993 Spore germination protein [General function prediction only]; Region: COG5401 692420007994 Sporulation and spore germination; Region: Germane; pfam10646 692420007995 glutamate racemase; Provisional; Region: PRK00865 692420007996 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420007997 MarR family; Region: MarR; pfam01047 692420007998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420007999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420008000 DNA binding residues [nucleotide binding] 692420008001 dimerization interface [polypeptide binding]; other site 692420008002 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 692420008003 active site 692420008004 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 692420008005 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 692420008006 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 692420008007 L-aspartate oxidase; Provisional; Region: PRK06175 692420008008 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 692420008009 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 692420008010 putative Iron-sulfur protein interface [polypeptide binding]; other site 692420008011 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 692420008012 proximal heme binding site [chemical binding]; other site 692420008013 distal heme binding site [chemical binding]; other site 692420008014 putative dimer interface [polypeptide binding]; other site 692420008015 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 692420008016 aspartate kinase; Reviewed; Region: PRK06635 692420008017 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 692420008018 putative nucleotide binding site [chemical binding]; other site 692420008019 putative catalytic residues [active] 692420008020 putative Mg ion binding site [ion binding]; other site 692420008021 putative aspartate binding site [chemical binding]; other site 692420008022 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 692420008023 putative allosteric regulatory site; other site 692420008024 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 692420008025 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 692420008026 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 692420008027 GIY-YIG motif/motif A; other site 692420008028 active site 692420008029 catalytic site [active] 692420008030 putative DNA binding site [nucleotide binding]; other site 692420008031 metal binding site [ion binding]; metal-binding site 692420008032 UvrB/uvrC motif; Region: UVR; pfam02151 692420008033 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 692420008034 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 692420008035 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 692420008036 catalytic residues [active] 692420008037 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 692420008038 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 692420008039 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 692420008040 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 692420008041 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 692420008042 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 692420008043 Ligand binding site [chemical binding]; other site 692420008044 Electron transfer flavoprotein domain; Region: ETF; pfam01012 692420008045 enoyl-CoA hydratase; Provisional; Region: PRK07658 692420008046 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420008047 substrate binding site [chemical binding]; other site 692420008048 oxyanion hole (OAH) forming residues; other site 692420008049 trimer interface [polypeptide binding]; other site 692420008050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420008051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420008052 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 692420008053 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 692420008054 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 692420008055 acyl-activating enzyme (AAE) consensus motif; other site 692420008056 putative AMP binding site [chemical binding]; other site 692420008057 putative active site [active] 692420008058 putative CoA binding site [chemical binding]; other site 692420008059 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 692420008060 Predicted membrane protein [Function unknown]; Region: COG3766 692420008061 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 692420008062 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 692420008063 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 692420008064 MutS domain III; Region: MutS_III; pfam05192 692420008065 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 692420008066 Walker A/P-loop; other site 692420008067 ATP binding site [chemical binding]; other site 692420008068 Q-loop/lid; other site 692420008069 ABC transporter signature motif; other site 692420008070 Walker B; other site 692420008071 D-loop; other site 692420008072 H-loop/switch region; other site 692420008073 Smr domain; Region: Smr; pfam01713 692420008074 hypothetical protein; Provisional; Region: PRK08609 692420008075 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 692420008076 active site 692420008077 primer binding site [nucleotide binding]; other site 692420008078 NTP binding site [chemical binding]; other site 692420008079 metal binding triad [ion binding]; metal-binding site 692420008080 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 692420008081 active site 692420008082 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 692420008083 Colicin V production protein; Region: Colicin_V; pfam02674 692420008084 cell division protein ZapA; Provisional; Region: PRK14126 692420008085 ribonuclease HIII; Provisional; Region: PRK00996 692420008086 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 692420008087 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 692420008088 RNA/DNA hybrid binding site [nucleotide binding]; other site 692420008089 active site 692420008090 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 692420008091 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 692420008092 putative tRNA-binding site [nucleotide binding]; other site 692420008093 B3/4 domain; Region: B3_4; pfam03483 692420008094 tRNA synthetase B5 domain; Region: B5; smart00874 692420008095 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 692420008096 dimer interface [polypeptide binding]; other site 692420008097 motif 1; other site 692420008098 motif 3; other site 692420008099 motif 2; other site 692420008100 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 692420008101 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 692420008102 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 692420008103 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 692420008104 dimer interface [polypeptide binding]; other site 692420008105 motif 1; other site 692420008106 active site 692420008107 motif 2; other site 692420008108 motif 3; other site 692420008109 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 692420008110 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 692420008111 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 692420008112 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 692420008113 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 692420008114 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 692420008115 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 692420008116 FAD binding domain; Region: FAD_binding_4; pfam01565 692420008117 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 692420008118 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 692420008119 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 692420008120 Cysteine-rich domain; Region: CCG; pfam02754 692420008121 Cysteine-rich domain; Region: CCG; pfam02754 692420008122 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 692420008123 Carbon starvation protein CstA; Region: CstA; pfam02554 692420008124 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 692420008125 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 692420008126 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 692420008127 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 692420008128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420008129 dimer interface [polypeptide binding]; other site 692420008130 conserved gate region; other site 692420008131 putative PBP binding loops; other site 692420008132 ABC-ATPase subunit interface; other site 692420008133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420008134 dimer interface [polypeptide binding]; other site 692420008135 conserved gate region; other site 692420008136 putative PBP binding loops; other site 692420008137 ABC-ATPase subunit interface; other site 692420008138 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 692420008139 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 692420008140 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 692420008141 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 692420008142 active site 692420008143 metal binding site [ion binding]; metal-binding site 692420008144 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 692420008145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420008146 active site 692420008147 motif I; other site 692420008148 motif II; other site 692420008149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420008150 motif II; other site 692420008151 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 692420008152 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 692420008153 intersubunit interface [polypeptide binding]; other site 692420008154 active site 692420008155 Zn2+ binding site [ion binding]; other site 692420008156 ribulokinase; Provisional; Region: PRK04123 692420008157 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 692420008158 N- and C-terminal domain interface [polypeptide binding]; other site 692420008159 active site 692420008160 MgATP binding site [chemical binding]; other site 692420008161 catalytic site [active] 692420008162 metal binding site [ion binding]; metal-binding site 692420008163 carbohydrate binding site [chemical binding]; other site 692420008164 homodimer interface [polypeptide binding]; other site 692420008165 L-arabinose isomerase; Provisional; Region: PRK02929 692420008166 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 692420008167 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 692420008168 trimer interface [polypeptide binding]; other site 692420008169 putative substrate binding site [chemical binding]; other site 692420008170 putative metal binding site [ion binding]; other site 692420008171 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 692420008172 substrate binding site [chemical binding]; other site 692420008173 active site 692420008174 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 692420008175 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 692420008176 oligomer interface [polypeptide binding]; other site 692420008177 active site 692420008178 metal binding site [ion binding]; metal-binding site 692420008179 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 692420008180 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 692420008181 23S rRNA binding site [nucleotide binding]; other site 692420008182 L21 binding site [polypeptide binding]; other site 692420008183 L13 binding site [polypeptide binding]; other site 692420008184 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 692420008185 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 692420008186 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 692420008187 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 692420008188 antiholin-like protein LrgB; Provisional; Region: PRK04288 692420008189 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 692420008190 two-component response regulator; Provisional; Region: PRK14084 692420008191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420008192 active site 692420008193 phosphorylation site [posttranslational modification] 692420008194 intermolecular recognition site; other site 692420008195 dimerization interface [polypeptide binding]; other site 692420008196 LytTr DNA-binding domain; Region: LytTR; smart00850 692420008197 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 692420008198 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 692420008199 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 692420008200 Histidine kinase; Region: His_kinase; pfam06580 692420008201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420008202 ATP binding site [chemical binding]; other site 692420008203 Mg2+ binding site [ion binding]; other site 692420008204 G-X-G motif; other site 692420008205 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 692420008206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420008207 motif II; other site 692420008208 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 692420008209 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 692420008210 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 692420008211 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 692420008212 active site 692420008213 dimer interface [polypeptide binding]; other site 692420008214 motif 1; other site 692420008215 motif 2; other site 692420008216 motif 3; other site 692420008217 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 692420008218 anticodon binding site; other site 692420008219 YtxC-like family; Region: YtxC; pfam08812 692420008220 Uncharacterized conserved protein [Function unknown]; Region: COG0398 692420008221 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 692420008222 primosomal protein DnaI; Reviewed; Region: PRK08939 692420008223 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 692420008224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420008225 Walker A motif; other site 692420008226 ATP binding site [chemical binding]; other site 692420008227 Walker B motif; other site 692420008228 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 692420008229 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 692420008230 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 692420008231 ATP cone domain; Region: ATP-cone; pfam03477 692420008232 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 692420008233 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 692420008234 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 692420008235 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 692420008236 Predicted transcriptional regulators [Transcription]; Region: COG1733 692420008237 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 692420008238 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420008239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420008240 putative substrate translocation pore; other site 692420008241 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420008242 active site 692420008243 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420008244 catalytic tetrad [active] 692420008245 dephospho-CoA kinase; Region: TIGR00152 692420008246 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 692420008247 CoA-binding site [chemical binding]; other site 692420008248 ATP-binding [chemical binding]; other site 692420008249 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 692420008250 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 692420008251 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 692420008252 DNA binding site [nucleotide binding] 692420008253 catalytic residue [active] 692420008254 H2TH interface [polypeptide binding]; other site 692420008255 putative catalytic residues [active] 692420008256 turnover-facilitating residue; other site 692420008257 intercalation triad [nucleotide binding]; other site 692420008258 8OG recognition residue [nucleotide binding]; other site 692420008259 putative reading head residues; other site 692420008260 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 692420008261 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 692420008262 DNA polymerase I; Provisional; Region: PRK05755 692420008263 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 692420008264 active site 692420008265 metal binding site 1 [ion binding]; metal-binding site 692420008266 putative 5' ssDNA interaction site; other site 692420008267 metal binding site 3; metal-binding site 692420008268 metal binding site 2 [ion binding]; metal-binding site 692420008269 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 692420008270 putative DNA binding site [nucleotide binding]; other site 692420008271 putative metal binding site [ion binding]; other site 692420008272 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 692420008273 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 692420008274 active site 692420008275 DNA binding site [nucleotide binding] 692420008276 catalytic site [active] 692420008277 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 692420008278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420008279 putative active site [active] 692420008280 heme pocket [chemical binding]; other site 692420008281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420008282 dimer interface [polypeptide binding]; other site 692420008283 phosphorylation site [posttranslational modification] 692420008284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420008285 ATP binding site [chemical binding]; other site 692420008286 Mg2+ binding site [ion binding]; other site 692420008287 G-X-G motif; other site 692420008288 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420008289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420008290 active site 692420008291 phosphorylation site [posttranslational modification] 692420008292 intermolecular recognition site; other site 692420008293 dimerization interface [polypeptide binding]; other site 692420008294 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420008295 DNA binding site [nucleotide binding] 692420008296 malate dehydrogenase; Reviewed; Region: PRK06223 692420008297 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 692420008298 NAD(P) binding site [chemical binding]; other site 692420008299 dimer interface [polypeptide binding]; other site 692420008300 tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420008301 substrate binding site [chemical binding]; other site 692420008302 isocitrate dehydrogenase; Reviewed; Region: PRK07006 692420008303 isocitrate dehydrogenase; Validated; Region: PRK07362 692420008304 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 692420008305 dimer interface [polypeptide binding]; other site 692420008306 Citrate synthase; Region: Citrate_synt; pfam00285 692420008307 active site 692420008308 citrylCoA binding site [chemical binding]; other site 692420008309 oxalacetate/citrate binding site [chemical binding]; other site 692420008310 coenzyme A binding site [chemical binding]; other site 692420008311 catalytic triad [active] 692420008312 Protein of unknown function (DUF441); Region: DUF441; pfam04284 692420008313 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 692420008314 Domain of unknown function DUF20; Region: UPF0118; pfam01594 692420008315 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 692420008316 pyruvate kinase; Provisional; Region: PRK06354 692420008317 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 692420008318 domain interfaces; other site 692420008319 active site 692420008320 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 692420008321 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 692420008322 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 692420008323 active site 692420008324 ADP/pyrophosphate binding site [chemical binding]; other site 692420008325 dimerization interface [polypeptide binding]; other site 692420008326 allosteric effector site; other site 692420008327 fructose-1,6-bisphosphate binding site; other site 692420008328 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 692420008329 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 692420008330 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 692420008331 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 692420008332 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 692420008333 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 692420008334 Malic enzyme, N-terminal domain; Region: malic; pfam00390 692420008335 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 692420008336 putative NAD(P) binding site [chemical binding]; other site 692420008337 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 692420008338 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 692420008339 active site 692420008340 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 692420008341 generic binding surface I; other site 692420008342 generic binding surface II; other site 692420008343 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 692420008344 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 692420008345 DHH family; Region: DHH; pfam01368 692420008346 DHHA1 domain; Region: DHHA1; pfam02272 692420008347 YtpI-like protein; Region: YtpI; pfam14007 692420008348 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 692420008349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420008350 DNA-binding site [nucleotide binding]; DNA binding site 692420008351 DRTGG domain; Region: DRTGG; pfam07085 692420008352 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 692420008353 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 692420008354 active site 2 [active] 692420008355 active site 1 [active] 692420008356 metal-dependent hydrolase; Provisional; Region: PRK00685 692420008357 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 692420008358 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 692420008359 classical (c) SDRs; Region: SDR_c; cd05233 692420008360 NAD(P) binding site [chemical binding]; other site 692420008361 active site 692420008362 argininosuccinate lyase; Provisional; Region: PRK00855 692420008363 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 692420008364 active sites [active] 692420008365 tetramer interface [polypeptide binding]; other site 692420008366 argininosuccinate synthase; Provisional; Region: PRK13820 692420008367 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 692420008368 ANP binding site [chemical binding]; other site 692420008369 Substrate Binding Site II [chemical binding]; other site 692420008370 Substrate Binding Site I [chemical binding]; other site 692420008371 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 692420008372 MPT binding site; other site 692420008373 trimer interface [polypeptide binding]; other site 692420008374 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 692420008375 propionate/acetate kinase; Provisional; Region: PRK12379 692420008376 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 692420008377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420008378 S-adenosylmethionine binding site [chemical binding]; other site 692420008379 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 692420008380 dimer interface [polypeptide binding]; other site 692420008381 catalytic triad [active] 692420008382 peroxidatic and resolving cysteines [active] 692420008383 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 692420008384 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 692420008385 RDD family; Region: RDD; pfam06271 692420008386 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 692420008387 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 692420008388 tandem repeat interface [polypeptide binding]; other site 692420008389 oligomer interface [polypeptide binding]; other site 692420008390 active site residues [active] 692420008391 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 692420008392 ATP-NAD kinase; Region: NAD_kinase; pfam01513 692420008393 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 692420008394 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 692420008395 active site 692420008396 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 692420008397 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 692420008398 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 692420008399 active site 692420008400 acyl-activating enzyme (AAE) consensus motif; other site 692420008401 putative CoA binding site [chemical binding]; other site 692420008402 AMP binding site [chemical binding]; other site 692420008403 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 692420008404 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 692420008405 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 692420008406 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 692420008407 Ligand Binding Site [chemical binding]; other site 692420008408 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 692420008409 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 692420008410 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420008411 catalytic residue [active] 692420008412 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 692420008413 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 692420008414 TMPIT-like protein; Region: TMPIT; pfam07851 692420008415 histidinol-phosphatase; Reviewed; Region: PRK08123 692420008416 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 692420008417 active site 692420008418 dimer interface [polypeptide binding]; other site 692420008419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420008420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420008421 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 692420008422 GAF domain; Region: GAF_2; pfam13185 692420008423 GAF domain; Region: GAF_3; pfam13492 692420008424 GAF domain; Region: GAF_2; pfam13185 692420008425 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 692420008426 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 692420008427 metal binding site [ion binding]; metal-binding site 692420008428 active site 692420008429 I-site; other site 692420008430 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 692420008431 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 692420008432 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420008433 RNA binding surface [nucleotide binding]; other site 692420008434 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 692420008435 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 692420008436 heme-binding site [chemical binding]; other site 692420008437 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 692420008438 FAD binding pocket [chemical binding]; other site 692420008439 FAD binding motif [chemical binding]; other site 692420008440 phosphate binding motif [ion binding]; other site 692420008441 beta-alpha-beta structure motif; other site 692420008442 NAD binding pocket [chemical binding]; other site 692420008443 Heme binding pocket [chemical binding]; other site 692420008444 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 692420008445 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 692420008446 active site 692420008447 catalytic triad [active] 692420008448 oxyanion hole [active] 692420008449 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 692420008450 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 692420008451 Predicted transcriptional regulators [Transcription]; Region: COG1378 692420008452 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 692420008453 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 692420008454 C-terminal domain interface [polypeptide binding]; other site 692420008455 sugar binding site [chemical binding]; other site 692420008456 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 692420008457 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 692420008458 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 692420008459 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 692420008460 active site 692420008461 HIGH motif; other site 692420008462 dimer interface [polypeptide binding]; other site 692420008463 KMSKS motif; other site 692420008464 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420008465 RNA binding surface [nucleotide binding]; other site 692420008466 acetyl-CoA synthetase; Provisional; Region: PRK04319 692420008467 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 692420008468 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 692420008469 active site 692420008470 acyl-activating enzyme (AAE) consensus motif; other site 692420008471 putative CoA binding site [chemical binding]; other site 692420008472 AMP binding site [chemical binding]; other site 692420008473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420008474 Coenzyme A binding pocket [chemical binding]; other site 692420008475 FOG: CBS domain [General function prediction only]; Region: COG0517 692420008476 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 692420008477 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 692420008478 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 692420008479 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 692420008480 active site 692420008481 Zn binding site [ion binding]; other site 692420008482 flagellar motor protein MotS; Reviewed; Region: PRK06925 692420008483 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 692420008484 ligand binding site [chemical binding]; other site 692420008485 flagellar motor protein MotP; Reviewed; Region: PRK06926 692420008486 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 692420008487 catabolite control protein A; Region: ccpA; TIGR01481 692420008488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420008489 DNA binding site [nucleotide binding] 692420008490 domain linker motif; other site 692420008491 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 692420008492 dimerization interface [polypeptide binding]; other site 692420008493 effector binding site; other site 692420008494 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 692420008495 Chorismate mutase type II; Region: CM_2; cl00693 692420008496 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 692420008497 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 692420008498 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 692420008499 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 692420008500 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 692420008501 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 692420008502 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 692420008503 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 692420008504 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 692420008505 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 692420008506 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 692420008507 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 692420008508 putative tRNA-binding site [nucleotide binding]; other site 692420008509 hypothetical protein; Provisional; Region: PRK13668 692420008510 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 692420008511 catalytic residues [active] 692420008512 YtoQ family protein; Region: YtoQ_fam; TIGR03646 692420008513 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 692420008514 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 692420008515 oligomer interface [polypeptide binding]; other site 692420008516 active site 692420008517 metal binding site [ion binding]; metal-binding site 692420008518 Predicted small secreted protein [Function unknown]; Region: COG5584 692420008519 potential frameshift: common BLAST hit: gi|154687127|ref|YP_001422288.1| malate dehydrogenase 692420008520 similar to MalS fragment; 'intermediary metabolism; Metabolism of carbohydrates and related molecules; TCA cycle' 692420008521 similar to malate oxidoreductase fragment; Malic enzyme, N-terminal 692420008522 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 692420008523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420008524 S-adenosylmethionine binding site [chemical binding]; other site 692420008525 YtzH-like protein; Region: YtzH; pfam14165 692420008526 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 692420008527 active site 692420008528 ATP binding site [chemical binding]; other site 692420008529 Phosphotransferase enzyme family; Region: APH; pfam01636 692420008530 substrate binding site [chemical binding]; other site 692420008531 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 692420008532 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 692420008533 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 692420008534 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 692420008535 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 692420008536 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 692420008537 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 692420008538 dimer interface [polypeptide binding]; other site 692420008539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420008540 catalytic residue [active] 692420008541 dipeptidase PepV; Reviewed; Region: PRK07318 692420008542 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 692420008543 active site 692420008544 metal binding site [ion binding]; metal-binding site 692420008545 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 692420008546 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 692420008547 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 692420008548 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 692420008549 Walker A/P-loop; other site 692420008550 ATP binding site [chemical binding]; other site 692420008551 Q-loop/lid; other site 692420008552 ABC transporter signature motif; other site 692420008553 Walker B; other site 692420008554 D-loop; other site 692420008555 H-loop/switch region; other site 692420008556 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 692420008557 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 692420008558 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 692420008559 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 692420008560 RNA binding surface [nucleotide binding]; other site 692420008561 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 692420008562 active site 692420008563 uracil binding [chemical binding]; other site 692420008564 stage V sporulation protein B; Region: spore_V_B; TIGR02900 692420008565 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 692420008566 HI0933-like protein; Region: HI0933_like; pfam03486 692420008567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 692420008568 BCCT family transporter; Region: BCCT; pfam02028 692420008569 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 692420008570 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 692420008571 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420008572 PBP superfamily domain; Region: PBP_like_2; cl17296 692420008573 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 692420008574 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 692420008575 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 692420008576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420008577 dimer interface [polypeptide binding]; other site 692420008578 conserved gate region; other site 692420008579 putative PBP binding loops; other site 692420008580 ABC-ATPase subunit interface; other site 692420008581 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 692420008582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420008583 dimer interface [polypeptide binding]; other site 692420008584 conserved gate region; other site 692420008585 putative PBP binding loops; other site 692420008586 ABC-ATPase subunit interface; other site 692420008587 alpha-galactosidase; Provisional; Region: PRK15076 692420008588 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 692420008589 NAD binding site [chemical binding]; other site 692420008590 sugar binding site [chemical binding]; other site 692420008591 divalent metal binding site [ion binding]; other site 692420008592 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420008593 dimer interface [polypeptide binding]; other site 692420008594 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 692420008595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420008596 Coenzyme A binding pocket [chemical binding]; other site 692420008597 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 692420008598 active site residue [active] 692420008599 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 692420008600 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 692420008601 HIGH motif; other site 692420008602 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 692420008603 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 692420008604 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 692420008605 active site 692420008606 KMSKS motif; other site 692420008607 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 692420008608 tRNA binding surface [nucleotide binding]; other site 692420008609 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 692420008610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420008611 PAS domain; Region: PAS_9; pfam13426 692420008612 putative active site [active] 692420008613 heme pocket [chemical binding]; other site 692420008614 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 692420008615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420008616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420008617 putative substrate translocation pore; other site 692420008618 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 692420008619 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 692420008620 FtsX-like permease family; Region: FtsX; pfam02687 692420008621 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 692420008622 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 692420008623 Walker A/P-loop; other site 692420008624 ATP binding site [chemical binding]; other site 692420008625 Q-loop/lid; other site 692420008626 ABC transporter signature motif; other site 692420008627 Walker B; other site 692420008628 D-loop; other site 692420008629 H-loop/switch region; other site 692420008630 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420008631 dimer interface [polypeptide binding]; other site 692420008632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 692420008633 phosphorylation site [posttranslational modification] 692420008634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420008635 ATP binding site [chemical binding]; other site 692420008636 Mg2+ binding site [ion binding]; other site 692420008637 G-X-G motif; other site 692420008638 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420008639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420008640 active site 692420008641 phosphorylation site [posttranslational modification] 692420008642 intermolecular recognition site; other site 692420008643 dimerization interface [polypeptide binding]; other site 692420008644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420008645 DNA binding site [nucleotide binding] 692420008646 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 692420008647 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 692420008648 FtsX-like permease family; Region: FtsX; pfam02687 692420008649 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 692420008650 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 692420008651 Walker A/P-loop; other site 692420008652 ATP binding site [chemical binding]; other site 692420008653 Q-loop/lid; other site 692420008654 ABC transporter signature motif; other site 692420008655 Walker B; other site 692420008656 D-loop; other site 692420008657 H-loop/switch region; other site 692420008658 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 692420008659 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 692420008660 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420008661 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 692420008662 Walker A/P-loop; other site 692420008663 ATP binding site [chemical binding]; other site 692420008664 Q-loop/lid; other site 692420008665 ABC transporter signature motif; other site 692420008666 Walker B; other site 692420008667 D-loop; other site 692420008668 H-loop/switch region; other site 692420008669 Predicted transcriptional regulators [Transcription]; Region: COG1725 692420008670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420008671 DNA-binding site [nucleotide binding]; DNA binding site 692420008672 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 692420008673 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 692420008674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420008675 S-adenosylmethionine binding site [chemical binding]; other site 692420008676 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 692420008677 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 692420008678 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 692420008679 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 692420008680 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 692420008681 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 692420008682 trimer interface [polypeptide binding]; other site 692420008683 putative metal binding site [ion binding]; other site 692420008684 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 692420008685 Spore germination protein; Region: Spore_permease; cl17796 692420008686 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 692420008687 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 692420008688 active site 692420008689 dimer interface [polypeptide binding]; other site 692420008690 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 692420008691 Ligand Binding Site [chemical binding]; other site 692420008692 Molecular Tunnel; other site 692420008693 S-adenosylmethionine synthetase; Validated; Region: PRK05250 692420008694 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 692420008695 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 692420008696 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 692420008697 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 692420008698 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 692420008699 active site 692420008700 substrate-binding site [chemical binding]; other site 692420008701 metal-binding site [ion binding] 692420008702 ATP binding site [chemical binding]; other site 692420008703 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 692420008704 Dienelactone hydrolase family; Region: DLH; pfam01738 692420008705 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 692420008706 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 692420008707 NMT1-like family; Region: NMT1_2; pfam13379 692420008708 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 692420008709 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 692420008710 Walker A/P-loop; other site 692420008711 ATP binding site [chemical binding]; other site 692420008712 Q-loop/lid; other site 692420008713 ABC transporter signature motif; other site 692420008714 Walker B; other site 692420008715 D-loop; other site 692420008716 H-loop/switch region; other site 692420008717 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 692420008718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420008719 dimer interface [polypeptide binding]; other site 692420008720 conserved gate region; other site 692420008721 putative PBP binding loops; other site 692420008722 ABC-ATPase subunit interface; other site 692420008723 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 692420008724 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 692420008725 nudix motif; other site 692420008726 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 692420008727 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 692420008728 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 692420008729 dimerization interface [polypeptide binding]; other site 692420008730 DPS ferroxidase diiron center [ion binding]; other site 692420008731 ion pore; other site 692420008732 YtkA-like; Region: YtkA; pfam13115 692420008733 S-ribosylhomocysteinase; Provisional; Region: PRK02260 692420008734 Haemolytic domain; Region: Haemolytic; pfam01809 692420008735 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 692420008736 active site clefts [active] 692420008737 zinc binding site [ion binding]; other site 692420008738 dimer interface [polypeptide binding]; other site 692420008739 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 692420008740 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 692420008741 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 692420008742 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 692420008743 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 692420008744 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 692420008745 active site 692420008746 octamer interface [polypeptide binding]; other site 692420008747 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 692420008748 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 692420008749 acyl-activating enzyme (AAE) consensus motif; other site 692420008750 putative AMP binding site [chemical binding]; other site 692420008751 putative active site [active] 692420008752 putative CoA binding site [chemical binding]; other site 692420008753 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420008754 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 692420008755 substrate binding site [chemical binding]; other site 692420008756 oxyanion hole (OAH) forming residues; other site 692420008757 trimer interface [polypeptide binding]; other site 692420008758 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 692420008759 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 692420008760 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 692420008761 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 692420008762 dimer interface [polypeptide binding]; other site 692420008763 tetramer interface [polypeptide binding]; other site 692420008764 PYR/PP interface [polypeptide binding]; other site 692420008765 TPP binding site [chemical binding]; other site 692420008766 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 692420008767 TPP-binding site; other site 692420008768 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 692420008769 chorismate binding enzyme; Region: Chorismate_bind; cl10555 692420008770 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 692420008771 TspO/MBR family; Region: TspO_MBR; pfam03073 692420008772 Predicted membrane protein [Function unknown]; Region: COG3859 692420008773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 692420008774 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 692420008775 DinB superfamily; Region: DinB_2; pfam12867 692420008776 DinB family; Region: DinB; cl17821 692420008777 MOSC domain; Region: MOSC; pfam03473 692420008778 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 692420008779 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 692420008780 active site 692420008781 NAD binding site [chemical binding]; other site 692420008782 metal binding site [ion binding]; metal-binding site 692420008783 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 692420008784 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 692420008785 tetramerization interface [polypeptide binding]; other site 692420008786 NAD(P) binding site [chemical binding]; other site 692420008787 catalytic residues [active] 692420008788 Predicted transcriptional regulators [Transcription]; Region: COG1510 692420008789 MarR family; Region: MarR_2; pfam12802 692420008790 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 692420008791 TrkA-N domain; Region: TrkA_N; pfam02254 692420008792 TrkA-C domain; Region: TrkA_C; pfam02080 692420008793 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 692420008794 SH3-like domain; Region: SH3_8; pfam13457 692420008795 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 692420008796 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 692420008797 heme-binding site [chemical binding]; other site 692420008798 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 692420008799 FAD binding pocket [chemical binding]; other site 692420008800 FAD binding motif [chemical binding]; other site 692420008801 phosphate binding motif [ion binding]; other site 692420008802 beta-alpha-beta structure motif; other site 692420008803 NAD binding pocket [chemical binding]; other site 692420008804 Heme binding pocket [chemical binding]; other site 692420008805 Cupin domain; Region: Cupin_2; cl17218 692420008806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 692420008807 binding surface 692420008808 TPR motif; other site 692420008809 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420008810 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420008811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420008812 binding surface 692420008813 TPR motif; other site 692420008814 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 692420008815 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 692420008816 Holin family; Region: Phage_holin_4; cl01989 692420008817 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 692420008818 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 692420008819 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 692420008820 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 692420008821 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 692420008822 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 692420008823 Phage tail protein; Region: Sipho_tail; pfam05709 692420008824 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 692420008825 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 692420008826 Phage-related protein [Function unknown]; Region: COG5412 692420008827 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 692420008828 N-acetyl-D-glucosamine binding site [chemical binding]; other site 692420008829 catalytic residue [active] 692420008830 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 692420008831 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 692420008832 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 692420008833 Phage capsid family; Region: Phage_capsid; pfam05065 692420008834 Phage portal protein; Region: Phage_portal; pfam04860 692420008835 Phage-related protein [Function unknown]; Region: COG4695; cl01923 692420008836 Phage Terminase; Region: Terminase_1; pfam03354 692420008837 Phage terminase, small subunit; Region: Terminase_4; pfam05119 692420008838 Prophage antirepressor [Transcription]; Region: COG3617 692420008839 BRO family, N-terminal domain; Region: Bro-N; smart01040 692420008840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420008841 non-specific DNA binding site [nucleotide binding]; other site 692420008842 salt bridge; other site 692420008843 sequence-specific DNA binding site [nucleotide binding]; other site 692420008844 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 692420008845 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 692420008846 Int/Topo IB signature motif; other site 692420008847 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 692420008848 Domain of unknown function DUF20; Region: UPF0118; pfam01594 692420008849 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 692420008850 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 692420008851 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 692420008852 intracellular protease, PfpI family; Region: PfpI; TIGR01382 692420008853 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 692420008854 proposed catalytic triad [active] 692420008855 conserved cys residue [active] 692420008856 Tar ligand binding domain homologue; Region: TarH; pfam02203 692420008857 Cache domain; Region: Cache_1; pfam02743 692420008858 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420008859 dimerization interface [polypeptide binding]; other site 692420008860 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 692420008861 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420008862 dimer interface [polypeptide binding]; other site 692420008863 putative CheW interface [polypeptide binding]; other site 692420008864 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 692420008865 Cache domain; Region: Cache_1; pfam02743 692420008866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420008867 dimerization interface [polypeptide binding]; other site 692420008868 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420008869 dimer interface [polypeptide binding]; other site 692420008870 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 692420008871 putative CheW interface [polypeptide binding]; other site 692420008872 Tar ligand binding domain homologue; Region: TarH; pfam02203 692420008873 Cache domain; Region: Cache_1; pfam02743 692420008874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420008875 dimerization interface [polypeptide binding]; other site 692420008876 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 692420008877 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420008878 dimer interface [polypeptide binding]; other site 692420008879 putative CheW interface [polypeptide binding]; other site 692420008880 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 692420008881 Cache domain; Region: Cache_1; pfam02743 692420008882 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420008883 dimerization interface [polypeptide binding]; other site 692420008884 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 692420008885 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 692420008886 dimer interface [polypeptide binding]; other site 692420008887 putative CheW interface [polypeptide binding]; other site 692420008888 transglutaminase; Provisional; Region: tgl; PRK03187 692420008889 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 692420008890 Nitronate monooxygenase; Region: NMO; pfam03060 692420008891 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 692420008892 FMN binding site [chemical binding]; other site 692420008893 substrate binding site [chemical binding]; other site 692420008894 putative catalytic residue [active] 692420008895 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 692420008896 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 692420008897 Ca binding site [ion binding]; other site 692420008898 active site 692420008899 catalytic site [active] 692420008900 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 692420008901 Domain of unknown function DUF21; Region: DUF21; pfam01595 692420008902 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 692420008903 Transporter associated domain; Region: CorC_HlyC; smart01091 692420008904 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 692420008905 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 692420008906 Ion channel; Region: Ion_trans_2; pfam07885 692420008907 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 692420008908 TrkA-N domain; Region: TrkA_N; pfam02254 692420008909 YugN-like family; Region: YugN; pfam08868 692420008910 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 692420008911 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 692420008912 active site 692420008913 dimer interface [polypeptide binding]; other site 692420008914 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 692420008915 dimer interface [polypeptide binding]; other site 692420008916 active site 692420008917 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 692420008918 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 692420008919 dimer interface [polypeptide binding]; other site 692420008920 active site 692420008921 metal binding site [ion binding]; metal-binding site 692420008922 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 692420008923 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 692420008924 dimer interface [polypeptide binding]; other site 692420008925 active site 692420008926 metal binding site [ion binding]; metal-binding site 692420008927 Uncharacterized conserved protein [Function unknown]; Region: COG2155 692420008928 general stress protein 13; Validated; Region: PRK08059 692420008929 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 692420008930 RNA binding site [nucleotide binding]; other site 692420008931 hypothetical protein; Validated; Region: PRK07682 692420008932 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420008933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420008934 homodimer interface [polypeptide binding]; other site 692420008935 catalytic residue [active] 692420008936 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 692420008937 AsnC family; Region: AsnC_trans_reg; pfam01037 692420008938 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 692420008939 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 692420008940 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 692420008941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420008942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420008943 homodimer interface [polypeptide binding]; other site 692420008944 catalytic residue [active] 692420008945 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420008946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420008947 dimer interface [polypeptide binding]; other site 692420008948 phosphorylation site [posttranslational modification] 692420008949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420008950 ATP binding site [chemical binding]; other site 692420008951 Mg2+ binding site [ion binding]; other site 692420008952 G-X-G motif; other site 692420008953 Kinase associated protein B; Region: KapB; pfam08810 692420008954 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 692420008955 active site 692420008956 catalytic site [active] 692420008957 substrate binding site [chemical binding]; other site 692420008958 sugar efflux transporter; Region: 2A0120; TIGR00899 692420008959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420008960 putative substrate translocation pore; other site 692420008961 Transglycosylase; Region: Transgly; pfam00912 692420008962 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 692420008963 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 692420008964 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 692420008965 sensory histidine kinase DcuS; Provisional; Region: PRK11086 692420008966 PAS domain; Region: PAS; smart00091 692420008967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420008968 ATP binding site [chemical binding]; other site 692420008969 Mg2+ binding site [ion binding]; other site 692420008970 G-X-G motif; other site 692420008971 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 692420008972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420008973 active site 692420008974 phosphorylation site [posttranslational modification] 692420008975 intermolecular recognition site; other site 692420008976 dimerization interface [polypeptide binding]; other site 692420008977 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 692420008978 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 692420008979 ligand binding site [chemical binding]; other site 692420008980 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 692420008981 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 692420008982 Walker A/P-loop; other site 692420008983 ATP binding site [chemical binding]; other site 692420008984 Q-loop/lid; other site 692420008985 ABC transporter signature motif; other site 692420008986 Walker B; other site 692420008987 D-loop; other site 692420008988 H-loop/switch region; other site 692420008989 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 692420008990 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 692420008991 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 692420008992 TM-ABC transporter signature motif; other site 692420008993 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 692420008994 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 692420008995 TM-ABC transporter signature motif; other site 692420008996 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 692420008997 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 692420008998 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 692420008999 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 692420009000 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 692420009001 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 692420009002 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 692420009003 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 692420009004 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 692420009005 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 692420009006 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 692420009007 CoenzymeA binding site [chemical binding]; other site 692420009008 subunit interaction site [polypeptide binding]; other site 692420009009 PHB binding site; other site 692420009010 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420009011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420009012 active site 692420009013 phosphorylation site [posttranslational modification] 692420009014 intermolecular recognition site; other site 692420009015 dimerization interface [polypeptide binding]; other site 692420009016 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420009017 DNA binding residues [nucleotide binding] 692420009018 dimerization interface [polypeptide binding]; other site 692420009019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 692420009020 Histidine kinase; Region: HisKA_3; pfam07730 692420009021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420009022 ATP binding site [chemical binding]; other site 692420009023 Mg2+ binding site [ion binding]; other site 692420009024 G-X-G motif; other site 692420009025 Bacillus competence pheromone ComX; Region: ComX; pfam05952 692420009026 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 692420009027 aspartate-rich region 2; other site 692420009028 DegQ (SacQ) family; Region: DegQ; pfam08181 692420009029 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 692420009030 EAL domain; Region: EAL; pfam00563 692420009031 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 692420009032 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 692420009033 active site 692420009034 Isochorismatase family; Region: Isochorismatase; pfam00857 692420009035 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 692420009036 catalytic triad [active] 692420009037 conserved cis-peptide bond; other site 692420009038 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 692420009039 YueH-like protein; Region: YueH; pfam14166 692420009040 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 692420009041 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 692420009042 Domain of unknown function DUF20; Region: UPF0118; pfam01594 692420009043 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 692420009044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 692420009045 Zn2+ binding site [ion binding]; other site 692420009046 Mg2+ binding site [ion binding]; other site 692420009047 short chain dehydrogenase; Provisional; Region: PRK06924 692420009048 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 692420009049 NADP binding site [chemical binding]; other site 692420009050 homodimer interface [polypeptide binding]; other site 692420009051 active site 692420009052 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 692420009053 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 692420009054 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 692420009055 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 692420009056 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 692420009057 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 692420009058 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 692420009059 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 692420009060 Domain of unknown function DUF87; Region: DUF87; pfam01935 692420009061 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 692420009062 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 692420009063 Uncharacterized small protein [Function unknown]; Region: COG5417 692420009064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 692420009065 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 692420009066 CodY GAF-like domain; Region: CodY; pfam06018 692420009067 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 692420009068 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 692420009069 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 692420009070 hexamer interface [polypeptide binding]; other site 692420009071 ligand binding site [chemical binding]; other site 692420009072 putative active site [active] 692420009073 NAD(P) binding site [chemical binding]; other site 692420009074 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 692420009075 MbtH-like protein; Region: MbtH; cl01279 692420009076 Condensation domain; Region: Condensation; pfam00668 692420009077 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 692420009078 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 692420009079 acyl-activating enzyme (AAE) consensus motif; other site 692420009080 AMP binding site [chemical binding]; other site 692420009081 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420009082 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 692420009083 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 692420009084 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 692420009085 acyl-activating enzyme (AAE) consensus motif; other site 692420009086 AMP binding site [chemical binding]; other site 692420009087 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 692420009088 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 692420009089 hydrophobic substrate binding pocket; other site 692420009090 Isochorismatase family; Region: Isochorismatase; pfam00857 692420009091 active site 692420009092 conserved cis-peptide bond; other site 692420009093 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 692420009094 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 692420009095 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 692420009096 acyl-activating enzyme (AAE) consensus motif; other site 692420009097 active site 692420009098 AMP binding site [chemical binding]; other site 692420009099 substrate binding site [chemical binding]; other site 692420009100 isochorismate synthase DhbC; Validated; Region: PRK06923 692420009101 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 692420009102 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 692420009103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009104 NAD(P) binding site [chemical binding]; other site 692420009105 active site 692420009106 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 692420009107 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 692420009108 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 692420009109 Moco binding site; other site 692420009110 metal coordination site [ion binding]; other site 692420009111 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 692420009112 Predicted permease [General function prediction only]; Region: COG2056 692420009113 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 692420009114 multifunctional aminopeptidase A; Provisional; Region: PRK00913 692420009115 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 692420009116 interface (dimer of trimers) [polypeptide binding]; other site 692420009117 Substrate-binding/catalytic site; other site 692420009118 Zn-binding sites [ion binding]; other site 692420009119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 692420009120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 692420009121 Putative membrane protein; Region: YuiB; pfam14068 692420009122 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 692420009123 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 692420009124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420009125 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 692420009126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 692420009127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420009128 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 692420009129 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 692420009130 active site 692420009131 Integral membrane protein DUF95; Region: DUF95; pfam01944 692420009132 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 692420009133 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 692420009134 Walker A/P-loop; other site 692420009135 ATP binding site [chemical binding]; other site 692420009136 Q-loop/lid; other site 692420009137 ABC transporter signature motif; other site 692420009138 Walker B; other site 692420009139 D-loop; other site 692420009140 H-loop/switch region; other site 692420009141 potential frameshift: common BLAST hit: gi|154687326|ref|YP_001422487.1| YjcK 692420009142 similar to ribosomal-protein-alanine acetyltransferase fragment; ribosomal-protein-alanine acetyltransferase;, Acyl-CoA N-acyltransferase 692420009143 similar to ribosomal-protein-alanine N-acetyltransferase fragment; 'information pathways; Protein modification' 692420009144 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 692420009145 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 692420009146 putative NAD(P) binding site [chemical binding]; other site 692420009147 active site 692420009148 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 692420009149 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 692420009150 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 692420009151 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 692420009152 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 692420009153 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 692420009154 Nucleoside recognition; Region: Gate; pfam07670 692420009155 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 692420009156 hypothetical protein; Provisional; Region: PRK13669 692420009157 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 692420009158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420009159 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 692420009160 NifU-like domain; Region: NifU; pfam01106 692420009161 potential frameshift: common BLAST hit: gi|154687335|ref|YP_001422496.1| YuxL 692420009162 similar to acylaminoacyl-peptidase fragment 692420009163 similar to acylaminoacyl-peptidase fragment; Protein tolB; flags: Precursor;, Six-bladed beta-propeller, TolB-like 692420009164 homoserine kinase; Region: thrB; TIGR00191 692420009165 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 692420009166 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 692420009167 threonine synthase; Reviewed; Region: PRK06721 692420009168 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 692420009169 homodimer interface [polypeptide binding]; other site 692420009170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420009171 catalytic residue [active] 692420009172 homoserine dehydrogenase; Provisional; Region: PRK06349 692420009173 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 692420009174 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 692420009175 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 692420009176 spore coat protein YutH; Region: spore_yutH; TIGR02905 692420009177 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 692420009178 tetramer interfaces [polypeptide binding]; other site 692420009179 binuclear metal-binding site [ion binding]; other site 692420009180 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 692420009181 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420009182 active site 692420009183 motif I; other site 692420009184 motif II; other site 692420009185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420009186 Uncharacterized conserved protein [Function unknown]; Region: COG2445 692420009187 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 692420009188 lipoyl synthase; Provisional; Region: PRK05481 692420009189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420009190 FeS/SAM binding site; other site 692420009191 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 692420009192 Peptidase family M23; Region: Peptidase_M23; pfam01551 692420009193 sporulation protein YunB; Region: spo_yunB; TIGR02832 692420009194 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 692420009195 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 692420009196 active site 692420009197 metal binding site [ion binding]; metal-binding site 692420009198 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 692420009199 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 692420009200 Uncharacterized conserved protein [Function unknown]; Region: COG1801 692420009201 allantoinase; Provisional; Region: PRK06189 692420009202 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 692420009203 active site 692420009204 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 692420009205 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 692420009206 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 692420009207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009208 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420009209 putative substrate translocation pore; other site 692420009210 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 692420009211 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420009212 catalytic residue [active] 692420009213 allantoate amidohydrolase; Reviewed; Region: PRK09290 692420009214 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 692420009215 active site 692420009216 metal binding site [ion binding]; metal-binding site 692420009217 dimer interface [polypeptide binding]; other site 692420009218 Endonuclease I; Region: Endonuclease_1; pfam04231 692420009219 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 692420009220 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 692420009221 Walker A/P-loop; other site 692420009222 ATP binding site [chemical binding]; other site 692420009223 Q-loop/lid; other site 692420009224 ABC transporter signature motif; other site 692420009225 Walker B; other site 692420009226 D-loop; other site 692420009227 H-loop/switch region; other site 692420009228 TOBE domain; Region: TOBE_2; pfam08402 692420009229 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 692420009230 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420009231 DNA-binding site [nucleotide binding]; DNA binding site 692420009232 UTRA domain; Region: UTRA; pfam07702 692420009233 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 692420009234 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 692420009235 substrate binding site [chemical binding]; other site 692420009236 ATP binding site [chemical binding]; other site 692420009237 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 692420009238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009239 dimer interface [polypeptide binding]; other site 692420009240 conserved gate region; other site 692420009241 putative PBP binding loops; other site 692420009242 ABC-ATPase subunit interface; other site 692420009243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009244 dimer interface [polypeptide binding]; other site 692420009245 conserved gate region; other site 692420009246 putative PBP binding loops; other site 692420009247 ABC-ATPase subunit interface; other site 692420009248 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 692420009249 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 692420009250 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 692420009251 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 692420009252 putative active site [active] 692420009253 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 692420009254 dimer interface [polypeptide binding]; other site 692420009255 active site 692420009256 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 692420009257 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 692420009258 DNA binding residues [nucleotide binding] 692420009259 dimer interface [polypeptide binding]; other site 692420009260 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 692420009261 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 692420009262 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 692420009263 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 692420009264 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 692420009265 GIY-YIG motif/motif A; other site 692420009266 active site 692420009267 catalytic site [active] 692420009268 putative DNA binding site [nucleotide binding]; other site 692420009269 metal binding site [ion binding]; metal-binding site 692420009270 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 692420009271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420009272 S-adenosylmethionine binding site [chemical binding]; other site 692420009273 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 692420009274 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 692420009275 chitosan binding site [chemical binding]; other site 692420009276 catalytic residues [active] 692420009277 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 692420009278 substrate binding site [chemical binding]; other site 692420009279 amidase catalytic site [active] 692420009280 Zn binding residues [ion binding]; other site 692420009281 Bacterial SH3 domain; Region: SH3_3; pfam08239 692420009282 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 692420009283 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 692420009284 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 692420009285 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 692420009286 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 692420009287 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 692420009288 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 692420009289 Phage tail protein; Region: Sipho_tail; pfam05709 692420009290 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 692420009291 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 692420009292 Phage-related protein [Function unknown]; Region: COG5412 692420009293 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 692420009294 N-acetyl-D-glucosamine binding site [chemical binding]; other site 692420009295 catalytic residue [active] 692420009296 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 692420009297 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 692420009298 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 692420009299 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 692420009300 oligomerization interface [polypeptide binding]; other site 692420009301 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 692420009302 Phage capsid family; Region: Phage_capsid; pfam05065 692420009303 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 692420009304 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 692420009305 Phage-related protein [Function unknown]; Region: COG4695; cl01923 692420009306 Phage Terminase; Region: Terminase_1; pfam03354 692420009307 Phage terminase, small subunit; Region: Terminase_4; pfam05119 692420009308 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 692420009309 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 692420009310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 692420009311 ATP binding site [chemical binding]; other site 692420009312 putative Mg++ binding site [ion binding]; other site 692420009313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420009314 nucleotide binding region [chemical binding]; other site 692420009315 ATP-binding site [chemical binding]; other site 692420009316 Virulence-associated protein E; Region: VirE; pfam05272 692420009317 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 692420009318 DNA binding site [nucleotide binding] 692420009319 active site 692420009320 catalytic site [active] 692420009321 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 692420009322 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 692420009323 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 692420009324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 692420009325 non-specific DNA binding site [nucleotide binding]; other site 692420009326 salt bridge; other site 692420009327 sequence-specific DNA binding site [nucleotide binding]; other site 692420009328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420009329 non-specific DNA binding site [nucleotide binding]; other site 692420009330 salt bridge; other site 692420009331 sequence-specific DNA binding site [nucleotide binding]; other site 692420009332 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 692420009333 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 692420009334 Int/Topo IB signature motif; other site 692420009335 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 692420009336 FeS assembly protein SufB; Region: sufB; TIGR01980 692420009337 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 692420009338 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 692420009339 trimerization site [polypeptide binding]; other site 692420009340 active site 692420009341 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 692420009342 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 692420009343 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420009344 catalytic residue [active] 692420009345 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 692420009346 FeS assembly protein SufD; Region: sufD; TIGR01981 692420009347 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 692420009348 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 692420009349 Walker A/P-loop; other site 692420009350 ATP binding site [chemical binding]; other site 692420009351 Q-loop/lid; other site 692420009352 ABC transporter signature motif; other site 692420009353 Walker B; other site 692420009354 D-loop; other site 692420009355 H-loop/switch region; other site 692420009356 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 692420009357 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 692420009358 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 692420009359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009360 dimer interface [polypeptide binding]; other site 692420009361 conserved gate region; other site 692420009362 ABC-ATPase subunit interface; other site 692420009363 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 692420009364 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 692420009365 Walker A/P-loop; other site 692420009366 ATP binding site [chemical binding]; other site 692420009367 Q-loop/lid; other site 692420009368 ABC transporter signature motif; other site 692420009369 Walker B; other site 692420009370 D-loop; other site 692420009371 H-loop/switch region; other site 692420009372 NIL domain; Region: NIL; pfam09383 692420009373 SCP-2 sterol transfer family; Region: SCP2; pfam02036 692420009374 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 692420009375 catalytic residues [active] 692420009376 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 692420009377 active site 692420009378 metal binding site [ion binding]; metal-binding site 692420009379 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 692420009380 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 692420009381 lipoyl attachment site [posttranslational modification]; other site 692420009382 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 692420009383 ArsC family; Region: ArsC; pfam03960 692420009384 putative ArsC-like catalytic residues; other site 692420009385 putative TRX-like catalytic residues [active] 692420009386 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 692420009387 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 692420009388 active site 692420009389 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 692420009390 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 692420009391 dimer interface [polypeptide binding]; other site 692420009392 active site 692420009393 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 692420009394 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 692420009395 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 692420009396 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 692420009397 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 692420009398 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 692420009399 substrate binding site [chemical binding]; other site 692420009400 oxyanion hole (OAH) forming residues; other site 692420009401 trimer interface [polypeptide binding]; other site 692420009402 YuzL-like protein; Region: YuzL; pfam14115 692420009403 Proline dehydrogenase; Region: Pro_dh; cl03282 692420009404 Pyruvate formate lyase; Region: PFL; pfam02901 692420009405 Coat F domain; Region: Coat_F; pfam07875 692420009406 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420009407 MarR family; Region: MarR; pfam01047 692420009408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420009410 putative substrate translocation pore; other site 692420009411 Restriction endonuclease BamHI; Region: BamHI; pfam02923 692420009412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420009413 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 692420009414 DNA methylase; Region: N6_N4_Mtase; pfam01555 692420009415 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 692420009416 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 692420009417 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 692420009418 Walker A/P-loop; other site 692420009419 ATP binding site [chemical binding]; other site 692420009420 Q-loop/lid; other site 692420009421 ABC transporter signature motif; other site 692420009422 Walker B; other site 692420009423 D-loop; other site 692420009424 H-loop/switch region; other site 692420009425 YusW-like protein; Region: YusW; pfam14039 692420009426 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 692420009427 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 692420009428 active site 692420009429 Zn binding site [ion binding]; other site 692420009430 short chain dehydrogenase; Provisional; Region: PRK06914 692420009431 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 692420009432 NADP binding site [chemical binding]; other site 692420009433 active site 692420009434 steroid binding site; other site 692420009435 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 692420009436 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 692420009437 dimerization interface [polypeptide binding]; other site 692420009438 DPS ferroxidase diiron center [ion binding]; other site 692420009439 ion pore; other site 692420009440 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 692420009441 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 692420009442 protein binding site [polypeptide binding]; other site 692420009443 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420009444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420009445 active site 692420009446 phosphorylation site [posttranslational modification] 692420009447 intermolecular recognition site; other site 692420009448 dimerization interface [polypeptide binding]; other site 692420009449 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420009450 DNA binding site [nucleotide binding] 692420009451 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420009452 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420009453 dimerization interface [polypeptide binding]; other site 692420009454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420009455 dimer interface [polypeptide binding]; other site 692420009456 phosphorylation site [posttranslational modification] 692420009457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420009458 ATP binding site [chemical binding]; other site 692420009459 Mg2+ binding site [ion binding]; other site 692420009460 G-X-G motif; other site 692420009461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420009462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420009463 fumarate hydratase; Reviewed; Region: fumC; PRK00485 692420009464 Class II fumarases; Region: Fumarase_classII; cd01362 692420009465 active site 692420009466 tetramer interface [polypeptide binding]; other site 692420009467 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 692420009468 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 692420009469 Spore germination protein; Region: Spore_permease; pfam03845 692420009470 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 692420009471 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 692420009472 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420009473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420009474 active site 692420009475 phosphorylation site [posttranslational modification] 692420009476 intermolecular recognition site; other site 692420009477 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420009478 DNA binding residues [nucleotide binding] 692420009479 dimerization interface [polypeptide binding]; other site 692420009480 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 692420009481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420009482 dimerization interface [polypeptide binding]; other site 692420009483 Histidine kinase; Region: HisKA_3; pfam07730 692420009484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420009485 ATP binding site [chemical binding]; other site 692420009486 Mg2+ binding site [ion binding]; other site 692420009487 G-X-G motif; other site 692420009488 Predicted membrane protein [Function unknown]; Region: COG4758 692420009489 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 692420009490 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 692420009491 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 692420009492 PspA/IM30 family; Region: PspA_IM30; pfam04012 692420009493 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 692420009494 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 692420009495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009496 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420009497 putative substrate translocation pore; other site 692420009498 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 692420009499 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 692420009500 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 692420009501 Walker A/P-loop; other site 692420009502 ATP binding site [chemical binding]; other site 692420009503 Q-loop/lid; other site 692420009504 ABC transporter signature motif; other site 692420009505 Walker B; other site 692420009506 D-loop; other site 692420009507 H-loop/switch region; other site 692420009508 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 692420009509 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 692420009510 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420009511 ABC-ATPase subunit interface; other site 692420009512 dimer interface [polypeptide binding]; other site 692420009513 putative PBP binding regions; other site 692420009514 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 692420009515 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 692420009516 putative binding site residues; other site 692420009517 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 692420009518 classical (c) SDRs; Region: SDR_c; cd05233 692420009519 NAD(P) binding site [chemical binding]; other site 692420009520 active site 692420009521 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 692420009522 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 692420009523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420009524 dimer interface [polypeptide binding]; other site 692420009525 phosphorylation site [posttranslational modification] 692420009526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420009527 ATP binding site [chemical binding]; other site 692420009528 Mg2+ binding site [ion binding]; other site 692420009529 G-X-G motif; other site 692420009530 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420009531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420009532 active site 692420009533 phosphorylation site [posttranslational modification] 692420009534 intermolecular recognition site; other site 692420009535 dimerization interface [polypeptide binding]; other site 692420009536 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420009537 DNA binding site [nucleotide binding] 692420009538 hypothetical protein; Provisional; Region: PRK14082 692420009539 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 692420009540 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 692420009541 DNA binding residues [nucleotide binding] 692420009542 YvrJ protein family; Region: YvrJ; pfam12841 692420009543 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 692420009544 Cupin; Region: Cupin_1; smart00835 692420009545 Cupin; Region: Cupin_1; smart00835 692420009546 Regulatory protein YrvL; Region: YrvL; pfam14184 692420009547 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 692420009548 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 692420009549 Walker A/P-loop; other site 692420009550 ATP binding site [chemical binding]; other site 692420009551 Q-loop/lid; other site 692420009552 ABC transporter signature motif; other site 692420009553 Walker B; other site 692420009554 D-loop; other site 692420009555 H-loop/switch region; other site 692420009556 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 692420009557 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420009558 ABC-ATPase subunit interface; other site 692420009559 dimer interface [polypeptide binding]; other site 692420009560 putative PBP binding regions; other site 692420009561 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 692420009562 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420009563 ABC-ATPase subunit interface; other site 692420009564 dimer interface [polypeptide binding]; other site 692420009565 putative PBP binding regions; other site 692420009566 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 692420009567 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 692420009568 putative ligand binding residues [chemical binding]; other site 692420009569 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 692420009570 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 692420009571 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 692420009572 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 692420009573 potential frameshift: common BLAST hit: gi|154687449|ref|YP_001422610.1| YvgJ 692420009574 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 692420009575 Sulfatase; Region: Sulfatase; cl17466 692420009576 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 692420009577 DNA binding domain, excisionase family; Region: excise; TIGR01764 692420009578 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 692420009579 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 692420009580 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 692420009581 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 692420009582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009583 dimer interface [polypeptide binding]; other site 692420009584 conserved gate region; other site 692420009585 putative PBP binding loops; other site 692420009586 ABC-ATPase subunit interface; other site 692420009587 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420009588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420009589 active site 692420009590 phosphorylation site [posttranslational modification] 692420009591 intermolecular recognition site; other site 692420009592 dimerization interface [polypeptide binding]; other site 692420009593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420009594 DNA binding residues [nucleotide binding] 692420009595 dimerization interface [polypeptide binding]; other site 692420009596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 692420009597 Histidine kinase; Region: HisKA_3; pfam07730 692420009598 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 692420009599 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420009600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420009601 Walker A/P-loop; other site 692420009602 ATP binding site [chemical binding]; other site 692420009603 Q-loop/lid; other site 692420009604 ABC transporter signature motif; other site 692420009605 Walker B; other site 692420009606 D-loop; other site 692420009607 H-loop/switch region; other site 692420009608 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 692420009609 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 692420009610 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 692420009611 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 692420009612 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 692420009613 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420009614 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420009615 active site 692420009616 catalytic tetrad [active] 692420009617 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 692420009618 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 692420009619 sulfite reductase subunit beta; Provisional; Region: PRK13504 692420009620 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 692420009621 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 692420009622 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 692420009623 Flavodoxin; Region: Flavodoxin_1; pfam00258 692420009624 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 692420009625 FAD binding pocket [chemical binding]; other site 692420009626 FAD binding motif [chemical binding]; other site 692420009627 catalytic residues [active] 692420009628 NAD binding pocket [chemical binding]; other site 692420009629 phosphate binding motif [ion binding]; other site 692420009630 beta-alpha-beta structure motif; other site 692420009631 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 692420009632 Family description; Region: UvrD_C_2; pfam13538 692420009633 Predicted membrane protein [Function unknown]; Region: COG2860 692420009634 UPF0126 domain; Region: UPF0126; pfam03458 692420009635 UPF0126 domain; Region: UPF0126; pfam03458 692420009636 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 692420009637 active site 692420009638 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 692420009639 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 692420009640 Thioredoxin; Region: Thioredoxin_4; pfam13462 692420009641 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 692420009642 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 692420009643 metal-binding site [ion binding] 692420009644 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 692420009645 Soluble P-type ATPase [General function prediction only]; Region: COG4087 692420009646 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 692420009647 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 692420009648 metal-binding site [ion binding] 692420009649 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 692420009650 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 692420009651 metal-binding site [ion binding] 692420009652 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 692420009653 Soluble P-type ATPase [General function prediction only]; Region: COG4087 692420009654 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 692420009655 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 692420009656 metal-binding site [ion binding] 692420009657 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 692420009658 putative homodimer interface [polypeptide binding]; other site 692420009659 putative homotetramer interface [polypeptide binding]; other site 692420009660 putative allosteric switch controlling residues; other site 692420009661 putative metal binding site [ion binding]; other site 692420009662 putative homodimer-homodimer interface [polypeptide binding]; other site 692420009663 putative oxidoreductase; Provisional; Region: PRK11579 692420009664 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 692420009665 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 692420009666 azoreductase; Reviewed; Region: PRK00170 692420009667 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 692420009668 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 692420009669 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 692420009670 active site 692420009671 non-prolyl cis peptide bond; other site 692420009672 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 692420009673 catalytic residues [active] 692420009674 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 692420009675 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 692420009676 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 692420009677 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 692420009678 Walker A/P-loop; other site 692420009679 ATP binding site [chemical binding]; other site 692420009680 Q-loop/lid; other site 692420009681 ABC transporter signature motif; other site 692420009682 Walker B; other site 692420009683 D-loop; other site 692420009684 H-loop/switch region; other site 692420009685 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 692420009686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009687 dimer interface [polypeptide binding]; other site 692420009688 conserved gate region; other site 692420009689 putative PBP binding loops; other site 692420009690 ABC-ATPase subunit interface; other site 692420009691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009692 dimer interface [polypeptide binding]; other site 692420009693 conserved gate region; other site 692420009694 putative PBP binding loops; other site 692420009695 ABC-ATPase subunit interface; other site 692420009696 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 692420009697 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420009698 substrate binding pocket [chemical binding]; other site 692420009699 membrane-bound complex binding site; other site 692420009700 hinge residues; other site 692420009701 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 692420009702 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 692420009703 substrate binding pocket [chemical binding]; other site 692420009704 membrane-bound complex binding site; other site 692420009705 hinge residues; other site 692420009706 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 692420009707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420009708 Coenzyme A binding pocket [chemical binding]; other site 692420009709 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 692420009710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420009711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 692420009712 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420009713 dimerization interface [polypeptide binding]; other site 692420009714 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 692420009715 classical (c) SDRs; Region: SDR_c; cd05233 692420009716 NAD(P) binding site [chemical binding]; other site 692420009717 active site 692420009718 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 692420009719 RNAase interaction site [polypeptide binding]; other site 692420009720 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 692420009721 SmpB-tmRNA interface; other site 692420009722 ribonuclease R; Region: RNase_R; TIGR02063 692420009723 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 692420009724 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 692420009725 RNB domain; Region: RNB; pfam00773 692420009726 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 692420009727 RNA binding site [nucleotide binding]; other site 692420009728 Esterase/lipase [General function prediction only]; Region: COG1647 692420009729 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 692420009730 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 692420009731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420009732 salt bridge; other site 692420009733 non-specific DNA binding site [nucleotide binding]; other site 692420009734 sequence-specific DNA binding site [nucleotide binding]; other site 692420009735 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420009736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420009737 non-specific DNA binding site [nucleotide binding]; other site 692420009738 salt bridge; other site 692420009739 sequence-specific DNA binding site [nucleotide binding]; other site 692420009740 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420009741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420009742 non-specific DNA binding site [nucleotide binding]; other site 692420009743 salt bridge; other site 692420009744 sequence-specific DNA binding site [nucleotide binding]; other site 692420009745 Predicted transcriptional regulators [Transcription]; Region: COG1733 692420009746 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420009747 dimerization interface [polypeptide binding]; other site 692420009748 putative DNA binding site [nucleotide binding]; other site 692420009749 putative Zn2+ binding site [ion binding]; other site 692420009750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420009751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420009752 dimer interface [polypeptide binding]; other site 692420009753 phosphorylation site [posttranslational modification] 692420009754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420009755 ATP binding site [chemical binding]; other site 692420009756 Mg2+ binding site [ion binding]; other site 692420009757 G-X-G motif; other site 692420009758 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420009759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420009760 active site 692420009761 phosphorylation site [posttranslational modification] 692420009762 intermolecular recognition site; other site 692420009763 dimerization interface [polypeptide binding]; other site 692420009764 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420009765 DNA binding site [nucleotide binding] 692420009766 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 692420009767 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 692420009768 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 692420009769 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 692420009770 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 692420009771 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 692420009772 Walker A/P-loop; other site 692420009773 ATP binding site [chemical binding]; other site 692420009774 Q-loop/lid; other site 692420009775 ABC transporter signature motif; other site 692420009776 Walker B; other site 692420009777 D-loop; other site 692420009778 H-loop/switch region; other site 692420009779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009780 dimer interface [polypeptide binding]; other site 692420009781 conserved gate region; other site 692420009782 putative PBP binding loops; other site 692420009783 ABC-ATPase subunit interface; other site 692420009784 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 692420009785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009786 dimer interface [polypeptide binding]; other site 692420009787 conserved gate region; other site 692420009788 putative PBP binding loops; other site 692420009789 ABC-ATPase subunit interface; other site 692420009790 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 692420009791 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 692420009792 Walker A/P-loop; other site 692420009793 ATP binding site [chemical binding]; other site 692420009794 Q-loop/lid; other site 692420009795 ABC transporter signature motif; other site 692420009796 Walker B; other site 692420009797 D-loop; other site 692420009798 H-loop/switch region; other site 692420009799 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 692420009800 Predicted transcriptional regulators [Transcription]; Region: COG1510 692420009801 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420009802 putative DNA binding site [nucleotide binding]; other site 692420009803 putative Zn2+ binding site [ion binding]; other site 692420009804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009805 dimer interface [polypeptide binding]; other site 692420009806 conserved gate region; other site 692420009807 putative PBP binding loops; other site 692420009808 ABC-ATPase subunit interface; other site 692420009809 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 692420009810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 692420009811 dimer interface [polypeptide binding]; other site 692420009812 conserved gate region; other site 692420009813 putative PBP binding loops; other site 692420009814 ABC-ATPase subunit interface; other site 692420009815 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 692420009816 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 692420009817 Walker A/P-loop; other site 692420009818 ATP binding site [chemical binding]; other site 692420009819 Q-loop/lid; other site 692420009820 ABC transporter signature motif; other site 692420009821 Walker B; other site 692420009822 D-loop; other site 692420009823 H-loop/switch region; other site 692420009824 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 692420009825 Predicted transcriptional regulators [Transcription]; Region: COG1510 692420009826 MarR family; Region: MarR_2; pfam12802 692420009827 membrane protein, MarC family; Region: TIGR00427 692420009828 Predicted membrane protein [Function unknown]; Region: COG4640 692420009829 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 692420009830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420009831 Coenzyme A binding pocket [chemical binding]; other site 692420009832 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420009833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009834 putative substrate translocation pore; other site 692420009835 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 692420009836 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 692420009837 WbqC-like protein family; Region: WbqC; pfam08889 692420009838 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 692420009839 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 692420009840 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 692420009841 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 692420009842 catalytic residue [active] 692420009843 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 692420009844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420009845 NAD(P) binding site [chemical binding]; other site 692420009846 active site 692420009847 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 692420009848 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 692420009849 inhibitor-cofactor binding pocket; inhibition site 692420009850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420009851 catalytic residue [active] 692420009852 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 692420009853 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 692420009854 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 692420009855 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 692420009856 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 692420009857 putative integrin binding motif; other site 692420009858 PA/protease domain interface [polypeptide binding]; other site 692420009859 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 692420009860 Peptidase family M28; Region: Peptidase_M28; pfam04389 692420009861 metal binding site [ion binding]; metal-binding site 692420009862 enolase; Provisional; Region: eno; PRK00077 692420009863 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 692420009864 dimer interface [polypeptide binding]; other site 692420009865 metal binding site [ion binding]; metal-binding site 692420009866 substrate binding pocket [chemical binding]; other site 692420009867 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 692420009868 phosphoglyceromutase; Provisional; Region: PRK05434 692420009869 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 692420009870 triosephosphate isomerase; Provisional; Region: PRK14565 692420009871 substrate binding site [chemical binding]; other site 692420009872 dimer interface [polypeptide binding]; other site 692420009873 catalytic triad [active] 692420009874 Phosphoglycerate kinase; Region: PGK; pfam00162 692420009875 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 692420009876 substrate binding site [chemical binding]; other site 692420009877 hinge regions; other site 692420009878 ADP binding site [chemical binding]; other site 692420009879 catalytic site [active] 692420009880 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 692420009881 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 692420009882 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 692420009883 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 692420009884 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 692420009885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009886 putative substrate translocation pore; other site 692420009887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420009888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420009889 DNA-binding site [nucleotide binding]; DNA binding site 692420009890 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420009891 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 692420009892 putative dimerization interface [polypeptide binding]; other site 692420009893 putative ligand binding site [chemical binding]; other site 692420009894 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 692420009895 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 692420009896 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 692420009897 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420009898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 692420009899 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420009900 dimerization interface [polypeptide binding]; other site 692420009901 EamA-like transporter family; Region: EamA; pfam00892 692420009902 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 692420009903 EamA-like transporter family; Region: EamA; pfam00892 692420009904 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 692420009905 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 692420009906 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 692420009907 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 692420009908 putative active site [active] 692420009909 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 692420009910 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 692420009911 N- and C-terminal domain interface [polypeptide binding]; other site 692420009912 active site 692420009913 catalytic site [active] 692420009914 metal binding site [ion binding]; metal-binding site 692420009915 carbohydrate binding site [chemical binding]; other site 692420009916 ATP binding site [chemical binding]; other site 692420009917 fructuronate transporter; Provisional; Region: PRK10034; cl15264 692420009918 GntP family permease; Region: GntP_permease; pfam02447 692420009919 Uncharacterized conserved protein [Function unknown]; Region: COG1556 692420009920 iron-sulfur cluster-binding protein; Region: TIGR00273 692420009921 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 692420009922 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 692420009923 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 692420009924 Cysteine-rich domain; Region: CCG; pfam02754 692420009925 Cysteine-rich domain; Region: CCG; pfam02754 692420009926 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 692420009927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420009928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420009929 homodimer interface [polypeptide binding]; other site 692420009930 catalytic residue [active] 692420009931 Transcriptional regulators [Transcription]; Region: FadR; COG2186 692420009932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420009933 DNA-binding site [nucleotide binding]; DNA binding site 692420009934 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 692420009935 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 692420009936 L-lactate permease; Region: Lactate_perm; pfam02652 692420009937 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 692420009938 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 692420009939 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 692420009940 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 692420009941 YvfG protein; Region: YvfG; pfam09628 692420009942 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 692420009943 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 692420009944 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 692420009945 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 692420009946 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 692420009947 inhibitor-cofactor binding pocket; inhibition site 692420009948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420009949 catalytic residue [active] 692420009950 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 692420009951 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 692420009952 putative trimer interface [polypeptide binding]; other site 692420009953 putative CoA binding site [chemical binding]; other site 692420009954 Bacterial sugar transferase; Region: Bac_transf; pfam02397 692420009955 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 692420009956 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 692420009957 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420009958 active site 692420009959 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 692420009960 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 692420009961 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420009962 active site 692420009963 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 692420009964 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 692420009965 putative ADP-binding pocket [chemical binding]; other site 692420009966 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 692420009967 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 692420009968 active site 692420009969 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 692420009970 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 692420009971 putative ADP-binding pocket [chemical binding]; other site 692420009972 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 692420009973 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 692420009974 NAD(P) binding site [chemical binding]; other site 692420009975 homodimer interface [polypeptide binding]; other site 692420009976 substrate binding site [chemical binding]; other site 692420009977 active site 692420009978 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 692420009979 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 692420009980 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 692420009981 Chain length determinant protein; Region: Wzz; cl15801 692420009982 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 692420009983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420009984 non-specific DNA binding site [nucleotide binding]; other site 692420009985 salt bridge; other site 692420009986 sequence-specific DNA binding site [nucleotide binding]; other site 692420009987 Anti-repressor SinI; Region: SinI; pfam08671 692420009988 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 692420009989 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 692420009990 substrate binding pocket [chemical binding]; other site 692420009991 catalytic triad [active] 692420009992 RibD C-terminal domain; Region: RibD_C; cl17279 692420009993 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 692420009994 hypothetical protein; Provisional; Region: PRK07236 692420009995 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 692420009996 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 692420009997 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 692420009998 Predicted membrane protein [Function unknown]; Region: COG2364 692420009999 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420010000 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 692420010001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420010002 Coenzyme A binding pocket [chemical binding]; other site 692420010003 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 692420010004 hypothetical protein; Provisional; Region: PRK00872 692420010005 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 692420010006 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 692420010007 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 692420010008 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 692420010009 nucleophilic elbow; other site 692420010010 catalytic triad; other site 692420010011 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 692420010012 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 692420010013 substrate binding [chemical binding]; other site 692420010014 active site 692420010015 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 692420010016 galactoside permease; Reviewed; Region: lacY; PRK09528 692420010017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010018 putative substrate translocation pore; other site 692420010019 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420010020 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420010021 DNA binding site [nucleotide binding] 692420010022 domain linker motif; other site 692420010023 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 692420010024 dimerization interface [polypeptide binding]; other site 692420010025 ligand binding site [chemical binding]; other site 692420010026 sodium binding site [ion binding]; other site 692420010027 Clp protease; Region: CLP_protease; pfam00574 692420010028 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 692420010029 oligomer interface [polypeptide binding]; other site 692420010030 active site residues [active] 692420010031 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420010032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 692420010033 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 692420010034 dimerization interface [polypeptide binding]; other site 692420010035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 692420010036 benzoate transport; Region: 2A0115; TIGR00895 692420010037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010038 putative substrate translocation pore; other site 692420010039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010040 TIGR00730 family protein; Region: TIGR00730 692420010041 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 692420010042 metal binding site [ion binding]; metal-binding site 692420010043 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 692420010044 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 692420010045 Sulfate transporter family; Region: Sulfate_transp; pfam00916 692420010046 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 692420010047 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 692420010048 active site clefts [active] 692420010049 zinc binding site [ion binding]; other site 692420010050 dimer interface [polypeptide binding]; other site 692420010051 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 692420010052 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 692420010053 dimerization interface [polypeptide binding]; other site 692420010054 ligand binding site [chemical binding]; other site 692420010055 NADP binding site [chemical binding]; other site 692420010056 catalytic site [active] 692420010057 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 692420010058 active site 692420010059 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 692420010060 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 692420010061 dimerization domain swap beta strand [polypeptide binding]; other site 692420010062 regulatory protein interface [polypeptide binding]; other site 692420010063 active site 692420010064 regulatory phosphorylation site [posttranslational modification]; other site 692420010065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 692420010066 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 692420010067 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 692420010068 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 692420010069 phosphate binding site [ion binding]; other site 692420010070 putative substrate binding pocket [chemical binding]; other site 692420010071 dimer interface [polypeptide binding]; other site 692420010072 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 692420010073 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 692420010074 putative active site [active] 692420010075 nucleotide binding site [chemical binding]; other site 692420010076 nudix motif; other site 692420010077 putative metal binding site [ion binding]; other site 692420010078 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 692420010079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 692420010080 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420010081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 692420010082 GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428 692420010083 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 692420010084 NlpC/P60 family; Region: NLPC_P60; pfam00877 692420010085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420010086 binding surface 692420010087 Tetratricopeptide repeat; Region: TPR_16; pfam13432 692420010088 TPR motif; other site 692420010089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420010090 TPR motif; other site 692420010091 binding surface 692420010092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420010093 dimer interface [polypeptide binding]; other site 692420010094 phosphorylation site [posttranslational modification] 692420010095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420010096 ATP binding site [chemical binding]; other site 692420010097 Mg2+ binding site [ion binding]; other site 692420010098 G-X-G motif; other site 692420010099 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420010100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420010101 active site 692420010102 phosphorylation site [posttranslational modification] 692420010103 intermolecular recognition site; other site 692420010104 dimerization interface [polypeptide binding]; other site 692420010105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420010106 DNA binding site [nucleotide binding] 692420010107 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420010108 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 692420010109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420010110 Walker A/P-loop; other site 692420010111 ATP binding site [chemical binding]; other site 692420010112 Q-loop/lid; other site 692420010113 ABC transporter signature motif; other site 692420010114 Walker B; other site 692420010115 D-loop; other site 692420010116 H-loop/switch region; other site 692420010117 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 692420010118 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 692420010119 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 692420010120 metal binding site [ion binding]; metal-binding site 692420010121 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 692420010122 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 692420010123 substrate binding site [chemical binding]; other site 692420010124 glutamase interaction surface [polypeptide binding]; other site 692420010125 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 692420010126 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 692420010127 catalytic residues [active] 692420010128 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 692420010129 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 692420010130 putative active site [active] 692420010131 oxyanion strand; other site 692420010132 catalytic triad [active] 692420010133 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 692420010134 putative active site pocket [active] 692420010135 4-fold oligomerization interface [polypeptide binding]; other site 692420010136 metal binding residues [ion binding]; metal-binding site 692420010137 3-fold/trimer interface [polypeptide binding]; other site 692420010138 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 692420010139 histidinol dehydrogenase; Region: hisD; TIGR00069 692420010140 NAD binding site [chemical binding]; other site 692420010141 dimerization interface [polypeptide binding]; other site 692420010142 product binding site; other site 692420010143 substrate binding site [chemical binding]; other site 692420010144 zinc binding site [ion binding]; other site 692420010145 catalytic residues [active] 692420010146 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 692420010147 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 692420010148 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 692420010149 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 692420010150 dimer interface [polypeptide binding]; other site 692420010151 motif 1; other site 692420010152 active site 692420010153 motif 2; other site 692420010154 motif 3; other site 692420010155 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 692420010156 putative active site [active] 692420010157 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 692420010158 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 692420010159 trimer interface [polypeptide binding]; other site 692420010160 active site 692420010161 substrate binding site [chemical binding]; other site 692420010162 CoA binding site [chemical binding]; other site 692420010163 pyrophosphatase PpaX; Provisional; Region: PRK13288 692420010164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 692420010165 motif I; other site 692420010166 active site 692420010167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420010168 motif II; other site 692420010169 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 692420010170 HPr kinase/phosphorylase; Provisional; Region: PRK05428 692420010171 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 692420010172 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 692420010173 Hpr binding site; other site 692420010174 active site 692420010175 homohexamer subunit interaction site [polypeptide binding]; other site 692420010176 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 692420010177 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 692420010178 active site 692420010179 dimer interface [polypeptide binding]; other site 692420010180 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 692420010181 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 692420010182 active site 692420010183 trimer interface [polypeptide binding]; other site 692420010184 allosteric site; other site 692420010185 active site lid [active] 692420010186 hexamer (dimer of trimers) interface [polypeptide binding]; other site 692420010187 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 692420010188 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420010189 DNA-binding site [nucleotide binding]; DNA binding site 692420010190 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 692420010191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420010192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420010193 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 692420010194 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 692420010195 putative active site [active] 692420010196 putative metal binding site [ion binding]; other site 692420010197 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 692420010198 Predicted membrane protein [Function unknown]; Region: COG1950 692420010199 PspC domain; Region: PspC; pfam04024 692420010200 Uncharacterized conserved protein [Function unknown]; Region: COG3595 692420010201 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 692420010202 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 692420010203 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 692420010204 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 692420010205 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 692420010206 excinuclease ABC subunit B; Provisional; Region: PRK05298 692420010207 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420010208 ATP binding site [chemical binding]; other site 692420010209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420010210 nucleotide binding region [chemical binding]; other site 692420010211 ATP-binding site [chemical binding]; other site 692420010212 Ultra-violet resistance protein B; Region: UvrB; pfam12344 692420010213 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 692420010214 phosphoenolpyruvate synthase; Validated; Region: PRK06241 692420010215 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 692420010216 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 692420010217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420010218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420010219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010220 putative substrate translocation pore; other site 692420010221 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 692420010222 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 692420010223 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 692420010224 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 692420010225 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 692420010226 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 692420010227 C-terminal peptidase (prc); Region: prc; TIGR00225 692420010228 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 692420010229 protein binding site [polypeptide binding]; other site 692420010230 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 692420010231 Catalytic dyad [active] 692420010232 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 692420010233 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 692420010234 Right handed beta helix region; Region: Beta_helix; pfam13229 692420010235 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 692420010236 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 692420010237 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 692420010238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420010239 Walker A/P-loop; other site 692420010240 ATP binding site [chemical binding]; other site 692420010241 Q-loop/lid; other site 692420010242 ABC transporter signature motif; other site 692420010243 Walker B; other site 692420010244 D-loop; other site 692420010245 H-loop/switch region; other site 692420010246 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 692420010247 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 692420010248 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420010249 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420010250 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420010251 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 692420010252 peptide chain release factor 2; Provisional; Region: PRK06746 692420010253 This domain is found in peptide chain release factors; Region: PCRF; smart00937 692420010254 RF-1 domain; Region: RF-1; pfam00472 692420010255 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 692420010256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 692420010257 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 692420010258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 692420010259 nucleotide binding region [chemical binding]; other site 692420010260 ATP-binding site [chemical binding]; other site 692420010261 SEC-C motif; Region: SEC-C; pfam02810 692420010262 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 692420010263 30S subunit binding site; other site 692420010264 Flagellar protein FliT; Region: FliT; pfam05400 692420010265 flagellar protein FliS; Validated; Region: fliS; PRK05685 692420010266 flagellar capping protein; Validated; Region: fliD; PRK07737 692420010267 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 692420010268 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 692420010269 flagellin; Provisional; Region: PRK12804 692420010270 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 692420010271 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 692420010272 carbon storage regulator; Provisional; Region: PRK01712 692420010273 flagellar assembly protein FliW; Provisional; Region: PRK13285 692420010274 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 692420010275 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 692420010276 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 692420010277 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 692420010278 FlgN protein; Region: FlgN; pfam05130 692420010279 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 692420010280 flagellar operon protein TIGR03826; Region: YvyF 692420010281 comF family protein; Region: comF; TIGR00201 692420010282 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420010283 active site 692420010284 Late competence development protein ComFB; Region: ComFB; pfam10719 692420010285 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 692420010286 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420010287 ATP binding site [chemical binding]; other site 692420010288 putative Mg++ binding site [ion binding]; other site 692420010289 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420010290 nucleotide binding region [chemical binding]; other site 692420010291 ATP-binding site [chemical binding]; other site 692420010292 EDD domain protein, DegV family; Region: DegV; TIGR00762 692420010293 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 692420010294 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420010295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420010296 active site 692420010297 phosphorylation site [posttranslational modification] 692420010298 intermolecular recognition site; other site 692420010299 dimerization interface [polypeptide binding]; other site 692420010300 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420010301 DNA binding residues [nucleotide binding] 692420010302 dimerization interface [polypeptide binding]; other site 692420010303 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 692420010304 Histidine kinase; Region: HisKA_3; pfam07730 692420010305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420010306 ATP binding site [chemical binding]; other site 692420010307 Mg2+ binding site [ion binding]; other site 692420010308 G-X-G motif; other site 692420010309 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 692420010310 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 692420010311 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 692420010312 Transcriptional regulator [Transcription]; Region: LytR; COG1316 692420010313 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 692420010314 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 692420010315 Mg++ binding site [ion binding]; other site 692420010316 putative catalytic motif [active] 692420010317 substrate binding site [chemical binding]; other site 692420010318 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 692420010319 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 692420010320 putative homodimer interface [polypeptide binding]; other site 692420010321 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 692420010322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420010323 active site 692420010324 Chain length determinant protein; Region: Wzz; cl15801 692420010325 O-Antigen ligase; Region: Wzy_C; pfam04932 692420010326 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 692420010327 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 692420010328 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 692420010329 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 692420010330 glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095 692420010331 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 692420010332 colanic acid exporter; Provisional; Region: PRK10459 692420010333 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 692420010334 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 692420010335 Bacterial sugar transferase; Region: Bac_transf; pfam02397 692420010336 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 692420010337 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 692420010338 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 692420010339 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 692420010340 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 692420010341 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 692420010342 active site 692420010343 metal binding site [ion binding]; metal-binding site 692420010344 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 692420010345 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 692420010346 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 692420010347 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 692420010348 Stage II sporulation protein; Region: SpoIID; pfam08486 692420010349 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 692420010350 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 692420010351 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 692420010352 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 692420010353 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 692420010354 active site 692420010355 homodimer interface [polypeptide binding]; other site 692420010356 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 692420010357 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 692420010358 active site 692420010359 tetramer interface; other site 692420010360 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 692420010361 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 692420010362 Walker A/P-loop; other site 692420010363 ATP binding site [chemical binding]; other site 692420010364 Q-loop/lid; other site 692420010365 ABC transporter signature motif; other site 692420010366 Walker B; other site 692420010367 D-loop; other site 692420010368 H-loop/switch region; other site 692420010369 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 692420010370 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 692420010371 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 692420010372 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 692420010373 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 692420010374 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 692420010375 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 692420010376 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 692420010377 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 692420010378 active site 692420010379 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 692420010380 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 692420010381 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 692420010382 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 692420010383 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 692420010384 Bacterial SH3 domain; Region: SH3_3; pfam08239 692420010385 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 692420010386 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 692420010387 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 692420010388 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 692420010389 Spore germination protein; Region: Spore_permease; pfam03845 692420010390 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 692420010391 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 692420010392 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 692420010393 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 692420010394 Probable Catalytic site; other site 692420010395 metal-binding site 692420010396 Methyltransferase domain; Region: Methyltransf_23; pfam13489 692420010397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420010398 S-adenosylmethionine binding site [chemical binding]; other site 692420010399 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 692420010400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010401 putative substrate translocation pore; other site 692420010402 Transcriptional regulator [Transcription]; Region: LytR; COG1316 692420010403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420010404 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 692420010405 active site 692420010406 motif I; other site 692420010407 motif II; other site 692420010408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420010409 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 692420010410 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 692420010411 NlpC/P60 family; Region: NLPC_P60; pfam00877 692420010412 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 692420010413 NlpC/P60 family; Region: NLPC_P60; pfam00877 692420010414 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 692420010415 NlpC/P60 family; Region: NLPC_P60; pfam00877 692420010416 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 692420010417 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 692420010418 putative active site [active] 692420010419 putative metal binding site [ion binding]; other site 692420010420 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 692420010421 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 692420010422 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 692420010423 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 692420010424 Spore germination protein; Region: Spore_permease; cl17796 692420010425 potential frameshift: common BLAST hit: gi|154687707|ref|YP_001422868.1| GerKC1 692420010426 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 692420010427 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 692420010428 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420010429 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420010430 DNA binding site [nucleotide binding] 692420010431 domain linker motif; other site 692420010432 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 692420010433 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 692420010434 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 692420010435 substrate binding site [chemical binding]; other site 692420010436 dimer interface [polypeptide binding]; other site 692420010437 ATP binding site [chemical binding]; other site 692420010438 D-ribose pyranase; Provisional; Region: PRK11797 692420010439 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 692420010440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420010441 Walker A/P-loop; other site 692420010442 ATP binding site [chemical binding]; other site 692420010443 Q-loop/lid; other site 692420010444 ABC transporter signature motif; other site 692420010445 Walker B; other site 692420010446 D-loop; other site 692420010447 H-loop/switch region; other site 692420010448 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 692420010449 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 692420010450 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 692420010451 TM-ABC transporter signature motif; other site 692420010452 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 692420010453 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 692420010454 ligand binding site [chemical binding]; other site 692420010455 dimerization interface [polypeptide binding]; other site 692420010456 Bacterial SH3 domain homologues; Region: SH3b; smart00287 692420010457 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 692420010458 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 692420010459 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 692420010460 acetolactate synthase; Reviewed; Region: PRK08617 692420010461 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 692420010462 PYR/PP interface [polypeptide binding]; other site 692420010463 dimer interface [polypeptide binding]; other site 692420010464 TPP binding site [chemical binding]; other site 692420010465 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 692420010466 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 692420010467 TPP-binding site [chemical binding]; other site 692420010468 dimer interface [polypeptide binding]; other site 692420010469 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 692420010470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 692420010471 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 692420010472 putative dimerization interface [polypeptide binding]; other site 692420010473 putative substrate binding pocket [chemical binding]; other site 692420010474 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 692420010475 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 692420010476 transmembrane helices; other site 692420010477 CotH protein; Region: CotH; pfam08757 692420010478 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 692420010479 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 692420010480 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 692420010481 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 692420010482 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 692420010483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420010484 putative DNA binding site [nucleotide binding]; other site 692420010485 putative Zn2+ binding site [ion binding]; other site 692420010486 AsnC family; Region: AsnC_trans_reg; pfam01037 692420010487 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 692420010488 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 692420010489 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 692420010490 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 692420010491 LXG domain of WXG superfamily; Region: LXG; pfam04740 692420010492 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 692420010493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 692420010494 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 692420010495 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 692420010496 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 692420010497 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 692420010498 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 692420010499 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 692420010500 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 692420010501 Nucleotide binding site [chemical binding]; other site 692420010502 DTAP/Switch II; other site 692420010503 Switch I; other site 692420010504 Chain length determinant protein; Region: Wzz; cl15801 692420010505 SWIM zinc finger; Region: SWIM; pfam04434 692420010506 SNF2 Helicase protein; Region: DUF3670; pfam12419 692420010507 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 692420010508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 692420010509 ATP binding site [chemical binding]; other site 692420010510 putative Mg++ binding site [ion binding]; other site 692420010511 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 692420010512 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420010513 nucleotide binding region [chemical binding]; other site 692420010514 ATP-binding site [chemical binding]; other site 692420010515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420010516 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 692420010517 active site 692420010518 motif I; other site 692420010519 motif II; other site 692420010520 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420010521 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 692420010522 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 692420010523 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 692420010524 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 692420010525 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 692420010526 dimer interface [polypeptide binding]; other site 692420010527 ssDNA binding site [nucleotide binding]; other site 692420010528 tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420010529 YwpF-like protein; Region: YwpF; pfam14183 692420010530 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 692420010531 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 692420010532 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 692420010533 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420010534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420010535 binding surface 692420010536 TPR motif; other site 692420010537 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420010538 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 692420010539 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 692420010540 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 692420010541 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 692420010542 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 692420010543 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 692420010544 rod shape-determining protein Mbl; Provisional; Region: PRK13928 692420010545 MreB and similar proteins; Region: MreB_like; cd10225 692420010546 nucleotide binding site [chemical binding]; other site 692420010547 Mg binding site [ion binding]; other site 692420010548 putative protofilament interaction site [polypeptide binding]; other site 692420010549 RodZ interaction site [polypeptide binding]; other site 692420010550 Stage III sporulation protein D; Region: SpoIIID; pfam12116 692420010551 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420010552 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420010553 putative Zn2+ binding site [ion binding]; other site 692420010554 putative DNA binding site [nucleotide binding]; other site 692420010555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010556 putative substrate translocation pore; other site 692420010557 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420010558 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 692420010559 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 692420010560 Na binding site [ion binding]; other site 692420010561 putative substrate binding site [chemical binding]; other site 692420010562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420010564 putative substrate translocation pore; other site 692420010565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010566 Isochorismatase family; Region: Isochorismatase; pfam00857 692420010567 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 692420010568 catalytic triad [active] 692420010569 conserved cis-peptide bond; other site 692420010570 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 692420010571 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 692420010572 Nitrogen regulatory protein P-II; Region: P-II; smart00938 692420010573 cell division protein FtsW; Region: ftsW; TIGR02614 692420010574 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 692420010575 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 692420010576 active site 692420010577 VanZ like family; Region: VanZ; pfam04892 692420010578 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 692420010579 Peptidase family M23; Region: Peptidase_M23; pfam01551 692420010580 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 692420010581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420010582 Coenzyme A binding pocket [chemical binding]; other site 692420010583 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 692420010584 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 692420010585 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 692420010586 putative active site [active] 692420010587 catalytic site [active] 692420010588 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 692420010589 putative active site [active] 692420010590 catalytic site [active] 692420010591 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 692420010592 NADH(P)-binding; Region: NAD_binding_10; pfam13460 692420010593 NAD binding site [chemical binding]; other site 692420010594 substrate binding site [chemical binding]; other site 692420010595 putative active site [active] 692420010596 Predicted transcriptional regulator [Transcription]; Region: COG1959 692420010597 Transcriptional regulator; Region: Rrf2; pfam02082 692420010598 urease subunit alpha; Reviewed; Region: ureC; PRK13207 692420010599 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 692420010600 subunit interactions [polypeptide binding]; other site 692420010601 active site 692420010602 flap region; other site 692420010603 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 692420010604 gamma-beta subunit interface [polypeptide binding]; other site 692420010605 alpha-beta subunit interface [polypeptide binding]; other site 692420010606 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 692420010607 alpha-gamma subunit interface [polypeptide binding]; other site 692420010608 beta-gamma subunit interface [polypeptide binding]; other site 692420010609 CsbD-like; Region: CsbD; pfam05532 692420010610 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 692420010611 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 692420010612 FeS/SAM binding site; other site 692420010613 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 692420010614 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 692420010615 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 692420010616 metal ion-dependent adhesion site (MIDAS); other site 692420010617 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 692420010618 metal ion-dependent adhesion site (MIDAS); other site 692420010619 Stage II sporulation protein; Region: SpoIID; pfam08486 692420010620 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 692420010621 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 692420010622 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 692420010623 hinge; other site 692420010624 active site 692420010625 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 692420010626 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 692420010627 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 692420010628 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 692420010629 gamma subunit interface [polypeptide binding]; other site 692420010630 epsilon subunit interface [polypeptide binding]; other site 692420010631 LBP interface [polypeptide binding]; other site 692420010632 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 692420010633 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 692420010634 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 692420010635 alpha subunit interaction interface [polypeptide binding]; other site 692420010636 Walker A motif; other site 692420010637 ATP binding site [chemical binding]; other site 692420010638 Walker B motif; other site 692420010639 inhibitor binding site; inhibition site 692420010640 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 692420010641 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 692420010642 core domain interface [polypeptide binding]; other site 692420010643 delta subunit interface [polypeptide binding]; other site 692420010644 epsilon subunit interface [polypeptide binding]; other site 692420010645 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 692420010646 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 692420010647 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 692420010648 beta subunit interaction interface [polypeptide binding]; other site 692420010649 Walker A motif; other site 692420010650 ATP binding site [chemical binding]; other site 692420010651 Walker B motif; other site 692420010652 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 692420010653 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 692420010654 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 692420010655 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 692420010656 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 692420010657 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 692420010658 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 692420010659 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 692420010660 ATP synthase I chain; Region: ATP_synt_I; pfam03899 692420010661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 692420010662 active site 692420010663 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 692420010664 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 692420010665 dimer interface [polypeptide binding]; other site 692420010666 active site 692420010667 glycine-pyridoxal phosphate binding site [chemical binding]; other site 692420010668 folate binding site [chemical binding]; other site 692420010669 hypothetical protein; Provisional; Region: PRK13690 692420010670 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 692420010671 Low molecular weight phosphatase family; Region: LMWPc; cd00115 692420010672 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 692420010673 active site 692420010674 Predicted membrane protein [Function unknown]; Region: COG1971 692420010675 Domain of unknown function DUF; Region: DUF204; pfam02659 692420010676 Domain of unknown function DUF; Region: DUF204; pfam02659 692420010677 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 692420010678 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 692420010679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 692420010680 stage II sporulation protein R; Region: spore_II_R; TIGR02837 692420010681 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 692420010682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420010683 S-adenosylmethionine binding site [chemical binding]; other site 692420010684 peptide chain release factor 1; Validated; Region: prfA; PRK00591 692420010685 This domain is found in peptide chain release factors; Region: PCRF; smart00937 692420010686 RF-1 domain; Region: RF-1; pfam00472 692420010687 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 692420010688 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420010689 putative metal binding site [ion binding]; other site 692420010690 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 692420010691 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 692420010692 DNA binding residues [nucleotide binding] 692420010693 Trypanosomal VSG domain; Region: VSG_B; cl11958 692420010694 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 692420010695 malate dehydrogenase; Provisional; Region: PRK13529 692420010696 Malic enzyme, N-terminal domain; Region: malic; pfam00390 692420010697 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 692420010698 NAD(P) binding site [chemical binding]; other site 692420010699 thymidine kinase; Provisional; Region: PRK04296 692420010700 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 692420010701 transcription termination factor Rho; Provisional; Region: rho; PRK09376 692420010702 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 692420010703 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 692420010704 RNA binding site [nucleotide binding]; other site 692420010705 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 692420010706 multimer interface [polypeptide binding]; other site 692420010707 Walker A motif; other site 692420010708 ATP binding site [chemical binding]; other site 692420010709 Walker B motif; other site 692420010710 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 692420010711 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 692420010712 putative active site [active] 692420010713 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 692420010714 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 692420010715 hinge; other site 692420010716 active site 692420010717 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 692420010718 active site 692420010719 intersubunit interactions; other site 692420010720 catalytic residue [active] 692420010721 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 692420010722 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 692420010723 intersubunit interface [polypeptide binding]; other site 692420010724 active site 692420010725 zinc binding site [ion binding]; other site 692420010726 Na+ binding site [ion binding]; other site 692420010727 Response regulator receiver domain; Region: Response_reg; pfam00072 692420010728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420010729 active site 692420010730 phosphorylation site [posttranslational modification] 692420010731 intermolecular recognition site; other site 692420010732 dimerization interface [polypeptide binding]; other site 692420010733 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 692420010734 CTP synthetase; Validated; Region: pyrG; PRK05380 692420010735 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 692420010736 Catalytic site [active] 692420010737 active site 692420010738 UTP binding site [chemical binding]; other site 692420010739 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 692420010740 active site 692420010741 putative oxyanion hole; other site 692420010742 catalytic triad [active] 692420010743 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 692420010744 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 692420010745 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 692420010746 Cysteine-rich domain; Region: CCG; pfam02754 692420010747 Cysteine-rich domain; Region: CCG; pfam02754 692420010748 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 692420010749 PLD-like domain; Region: PLDc_2; pfam13091 692420010750 putative active site [active] 692420010751 catalytic site [active] 692420010752 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 692420010753 PLD-like domain; Region: PLDc_2; pfam13091 692420010754 putative active site [active] 692420010755 catalytic site [active] 692420010756 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 692420010757 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 692420010758 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 692420010759 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 692420010760 Walker A/P-loop; other site 692420010761 ATP binding site [chemical binding]; other site 692420010762 Q-loop/lid; other site 692420010763 ABC transporter signature motif; other site 692420010764 Walker B; other site 692420010765 D-loop; other site 692420010766 H-loop/switch region; other site 692420010767 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 692420010768 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 692420010769 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 692420010770 putative active site [active] 692420010771 catalytic site [active] 692420010772 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 692420010773 putative active site [active] 692420010774 catalytic site [active] 692420010775 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 692420010776 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 692420010777 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 692420010778 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 692420010779 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 692420010780 [4Fe-4S] binding site [ion binding]; other site 692420010781 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 692420010782 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 692420010783 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 692420010784 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 692420010785 molybdopterin cofactor binding site; other site 692420010786 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 692420010787 ligand binding site [chemical binding]; other site 692420010788 flexible hinge region; other site 692420010789 YwiC-like protein; Region: YwiC; pfam14256 692420010790 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 692420010791 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 692420010792 ligand binding site [chemical binding]; other site 692420010793 flexible hinge region; other site 692420010794 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 692420010795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010796 putative substrate translocation pore; other site 692420010797 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 692420010798 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 692420010799 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 692420010800 active site 692420010801 HIGH motif; other site 692420010802 KMSK motif region; other site 692420010803 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 692420010804 tRNA binding surface [nucleotide binding]; other site 692420010805 anticodon binding site; other site 692420010806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 692420010807 potential frameshift: common BLAST hit: gi|154687850|ref|YP_001423011.1| YwhL 692420010808 Uncharacterized conserved protein [Function unknown]; Region: COG3391 692420010809 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 692420010810 Uncharacterized conserved protein [Function unknown]; Region: COG3391 692420010811 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 692420010812 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 692420010813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 692420010814 binding surface 692420010815 TPR motif; other site 692420010816 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420010817 agmatinase; Region: agmatinase; TIGR01230 692420010818 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 692420010819 putative active site [active] 692420010820 Mn binding site [ion binding]; other site 692420010821 spermidine synthase; Provisional; Region: PRK00811 692420010822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 692420010823 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 692420010824 Transglycosylase; Region: Transgly; pfam00912 692420010825 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 692420010826 YwhD family; Region: YwhD; pfam08741 692420010827 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 692420010828 Peptidase family M50; Region: Peptidase_M50; pfam02163 692420010829 active site 692420010830 putative substrate binding region [chemical binding]; other site 692420010831 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 692420010832 active site 1 [active] 692420010833 dimer interface [polypeptide binding]; other site 692420010834 hexamer interface [polypeptide binding]; other site 692420010835 active site 2 [active] 692420010836 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420010837 dimerization interface [polypeptide binding]; other site 692420010838 putative DNA binding site [nucleotide binding]; other site 692420010839 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420010840 putative Zn2+ binding site [ion binding]; other site 692420010841 amino acid transporter; Region: 2A0306; TIGR00909 692420010842 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 692420010843 Uncharacterized conserved protein [Function unknown]; Region: COG3465 692420010844 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 692420010845 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 692420010846 Zn2+ binding site [ion binding]; other site 692420010847 Mg2+ binding site [ion binding]; other site 692420010848 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 692420010849 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 692420010850 Predicted transcriptional regulators [Transcription]; Region: COG1695 692420010851 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 692420010852 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 692420010853 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 692420010854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420010855 Walker A/P-loop; other site 692420010856 ATP binding site [chemical binding]; other site 692420010857 Q-loop/lid; other site 692420010858 ABC transporter signature motif; other site 692420010859 Walker B; other site 692420010860 D-loop; other site 692420010861 H-loop/switch region; other site 692420010862 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 692420010863 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 692420010864 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 692420010865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420010866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 692420010867 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 692420010868 putative dimerization interface [polypeptide binding]; other site 692420010869 Predicted membrane protein [Function unknown]; Region: COG2855 692420010870 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 692420010871 putative heme peroxidase; Provisional; Region: PRK12276 692420010872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 692420010873 non-specific DNA binding site [nucleotide binding]; other site 692420010874 salt bridge; other site 692420010875 sequence-specific DNA binding site [nucleotide binding]; other site 692420010876 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 692420010877 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 692420010878 putative NAD(P) binding site [chemical binding]; other site 692420010879 putative active site [active] 692420010880 transaminase; Reviewed; Region: PRK08068 692420010881 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 692420010882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420010883 homodimer interface [polypeptide binding]; other site 692420010884 catalytic residue [active] 692420010885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010886 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420010887 putative substrate translocation pore; other site 692420010888 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 692420010889 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 692420010890 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 692420010891 classical (c) SDRs; Region: SDR_c; cd05233 692420010892 NAD(P) binding site [chemical binding]; other site 692420010893 active site 692420010894 Cupin domain; Region: Cupin_2; pfam07883 692420010895 Cupin domain; Region: Cupin_2; pfam07883 692420010896 Prephenate dehydratase; Region: PDT; pfam00800 692420010897 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420010898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010899 putative substrate translocation pore; other site 692420010900 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 692420010901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420010902 putative substrate translocation pore; other site 692420010903 S-methylmethionine transporter; Provisional; Region: PRK11387 692420010904 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 692420010905 putative metal binding site [ion binding]; other site 692420010906 putative dimer interface [polypeptide binding]; other site 692420010907 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 692420010908 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 692420010909 Glutamate binding site [chemical binding]; other site 692420010910 homodimer interface [polypeptide binding]; other site 692420010911 NAD binding site [chemical binding]; other site 692420010912 catalytic residues [active] 692420010913 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 692420010914 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 692420010915 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 692420010916 NAD(P) binding site [chemical binding]; other site 692420010917 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 692420010918 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 692420010919 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 692420010920 NADP binding site [chemical binding]; other site 692420010921 active site 692420010922 putative substrate binding site [chemical binding]; other site 692420010923 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 692420010924 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 692420010925 NAD binding site [chemical binding]; other site 692420010926 substrate binding site [chemical binding]; other site 692420010927 homodimer interface [polypeptide binding]; other site 692420010928 active site 692420010929 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 692420010930 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 692420010931 substrate binding site; other site 692420010932 tetramer interface; other site 692420010933 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 692420010934 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 692420010935 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 692420010936 ligand binding site; other site 692420010937 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 692420010938 NeuB family; Region: NeuB; pfam03102 692420010939 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 692420010940 NeuB binding interface [polypeptide binding]; other site 692420010941 putative substrate binding site [chemical binding]; other site 692420010942 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 692420010943 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 692420010944 Coenzyme A binding pocket [chemical binding]; other site 692420010945 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 692420010946 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 692420010947 inhibitor-cofactor binding pocket; inhibition site 692420010948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420010949 catalytic residue [active] 692420010950 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 692420010951 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 692420010952 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420010953 active site 692420010954 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 692420010955 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 692420010956 Permease family; Region: Xan_ur_permease; pfam00860 692420010957 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 692420010958 ligand binding site [chemical binding]; other site 692420010959 active site 692420010960 UGI interface [polypeptide binding]; other site 692420010961 catalytic site [active] 692420010962 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 692420010963 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 692420010964 active site 692420010965 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 692420010966 dimer interface [polypeptide binding]; other site 692420010967 substrate binding site [chemical binding]; other site 692420010968 ATP binding site [chemical binding]; other site 692420010969 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 692420010970 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 692420010971 substrate binding [chemical binding]; other site 692420010972 active site 692420010973 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 692420010974 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 692420010975 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420010976 active site turn [active] 692420010977 phosphorylation site [posttranslational modification] 692420010978 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 692420010979 transcriptional antiterminator BglG; Provisional; Region: PRK09772 692420010980 CAT RNA binding domain; Region: CAT_RBD; smart01061 692420010981 PRD domain; Region: PRD; pfam00874 692420010982 PRD domain; Region: PRD; pfam00874 692420010983 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 692420010984 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 692420010985 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 692420010986 putative active site [active] 692420010987 catalytic triad [active] 692420010988 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 692420010989 PA/protease domain interface [polypeptide binding]; other site 692420010990 putative integrin binding motif; other site 692420010991 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 692420010992 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 692420010993 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 692420010994 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 692420010995 Predicted transcriptional regulator [Transcription]; Region: COG2378 692420010996 HTH domain; Region: HTH_11; pfam08279 692420010997 WYL domain; Region: WYL; pfam13280 692420010998 short chain dehydrogenase; Provisional; Region: PRK06523 692420010999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 692420011000 NAD(P) binding site [chemical binding]; other site 692420011001 active site 692420011002 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 692420011003 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 692420011004 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 692420011005 dimer interface [polypeptide binding]; other site 692420011006 FMN binding site [chemical binding]; other site 692420011007 NADPH bind site [chemical binding]; other site 692420011008 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 692420011009 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 692420011010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420011011 Coenzyme A binding pocket [chemical binding]; other site 692420011012 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 692420011013 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 692420011014 Subunit I/III interface [polypeptide binding]; other site 692420011015 Subunit III/IV interface [polypeptide binding]; other site 692420011016 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 692420011017 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 692420011018 D-pathway; other site 692420011019 Putative ubiquinol binding site [chemical binding]; other site 692420011020 Low-spin heme (heme b) binding site [chemical binding]; other site 692420011021 Putative water exit pathway; other site 692420011022 Binuclear center (heme o3/CuB) [ion binding]; other site 692420011023 K-pathway; other site 692420011024 Putative proton exit pathway; other site 692420011025 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 692420011026 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 692420011027 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 692420011028 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 692420011029 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 692420011030 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 692420011031 galactokinase; Provisional; Region: PRK05322 692420011032 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 692420011033 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 692420011034 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 692420011035 Predicted membrane protein [Function unknown]; Region: COG2246 692420011036 GtrA-like protein; Region: GtrA; pfam04138 692420011037 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420011038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420011039 Uso1 / p115 like vesicle tethering protein, head region; Region: Uso1_p115_head; pfam04869 692420011040 Anti-repressor SinI; Region: SinI; pfam08671 692420011041 Methyltransferase domain; Region: Methyltransf_23; pfam13489 692420011042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420011043 S-adenosylmethionine binding site [chemical binding]; other site 692420011044 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 692420011045 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 692420011046 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 692420011047 catalytic residues [active] 692420011048 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 692420011049 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 692420011050 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 692420011051 Imelysin; Region: Peptidase_M75; pfam09375 692420011052 FTR1 family protein; Region: TIGR00145 692420011053 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 692420011054 thiamine phosphate binding site [chemical binding]; other site 692420011055 active site 692420011056 pyrophosphate binding site [ion binding]; other site 692420011057 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 692420011058 substrate binding site [chemical binding]; other site 692420011059 multimerization interface [polypeptide binding]; other site 692420011060 ATP binding site [chemical binding]; other site 692420011061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 692420011062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 692420011063 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 692420011064 putative dimerization interface [polypeptide binding]; other site 692420011065 LrgA family; Region: LrgA; cl00608 692420011066 LrgB-like family; Region: LrgB; cl00596 692420011067 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 692420011068 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 692420011069 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 692420011070 DNA binding residues [nucleotide binding] 692420011071 dimer interface [polypeptide binding]; other site 692420011072 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 692420011073 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 692420011074 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 692420011075 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 692420011076 putative RNA binding site [nucleotide binding]; other site 692420011077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420011078 S-adenosylmethionine binding site [chemical binding]; other site 692420011079 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420011080 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 692420011081 active site 692420011082 metal binding site [ion binding]; metal-binding site 692420011083 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 692420011084 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 692420011085 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 692420011086 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 692420011087 active site 692420011088 catalytic residues [active] 692420011089 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 692420011090 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 692420011091 Ligand binding site; other site 692420011092 metal-binding site 692420011093 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 692420011094 synthetase active site [active] 692420011095 NTP binding site [chemical binding]; other site 692420011096 metal binding site [ion binding]; metal-binding site 692420011097 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 692420011098 UbiA prenyltransferase family; Region: UbiA; pfam01040 692420011099 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 692420011100 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 692420011101 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 692420011102 acyl-activating enzyme (AAE) consensus motif; other site 692420011103 AMP binding site [chemical binding]; other site 692420011104 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 692420011105 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 692420011106 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 692420011107 DltD N-terminal region; Region: DltD_N; pfam04915 692420011108 DltD central region; Region: DltD_M; pfam04918 692420011109 DltD C-terminal region; Region: DltD_C; pfam04914 692420011110 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 692420011111 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 692420011112 homodimer interface [polypeptide binding]; other site 692420011113 substrate-cofactor binding pocket; other site 692420011114 catalytic residue [active] 692420011115 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 692420011116 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 692420011117 NAD binding site [chemical binding]; other site 692420011118 sugar binding site [chemical binding]; other site 692420011119 divalent metal binding site [ion binding]; other site 692420011120 tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420011121 dimer interface [polypeptide binding]; other site 692420011122 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 692420011123 methionine cluster; other site 692420011124 active site 692420011125 phosphorylation site [posttranslational modification] 692420011126 metal binding site [ion binding]; metal-binding site 692420011127 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 692420011128 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 692420011129 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 692420011130 active site 692420011131 P-loop; other site 692420011132 phosphorylation site [posttranslational modification] 692420011133 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 692420011134 HTH domain; Region: HTH_11; pfam08279 692420011135 Mga helix-turn-helix domain; Region: Mga; pfam05043 692420011136 PRD domain; Region: PRD; pfam00874 692420011137 PRD domain; Region: PRD; pfam00874 692420011138 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 692420011139 active site 692420011140 P-loop; other site 692420011141 phosphorylation site [posttranslational modification] 692420011142 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 692420011143 active site 692420011144 phosphorylation site [posttranslational modification] 692420011145 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 692420011146 active site 692420011147 DNA binding site [nucleotide binding] 692420011148 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 692420011149 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420011150 ABC-ATPase subunit interface; other site 692420011151 dimer interface [polypeptide binding]; other site 692420011152 putative PBP binding regions; other site 692420011153 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 692420011154 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 692420011155 ABC-ATPase subunit interface; other site 692420011156 dimer interface [polypeptide binding]; other site 692420011157 putative PBP binding regions; other site 692420011158 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 692420011159 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 692420011160 intersubunit interface [polypeptide binding]; other site 692420011161 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420011162 dimerization interface [polypeptide binding]; other site 692420011163 putative DNA binding site [nucleotide binding]; other site 692420011164 putative Zn2+ binding site [ion binding]; other site 692420011165 arsenical pump membrane protein; Provisional; Region: PRK15445 692420011166 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 692420011167 transmembrane helices; other site 692420011168 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 692420011169 active site 692420011170 P-loop; other site 692420011171 phosphorylation site [posttranslational modification] 692420011172 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 692420011173 active site 692420011174 methionine cluster; other site 692420011175 phosphorylation site [posttranslational modification] 692420011176 metal binding site [ion binding]; metal-binding site 692420011177 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 692420011178 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 692420011179 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 692420011180 beta-galactosidase; Region: BGL; TIGR03356 692420011181 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 692420011182 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 692420011183 nucleotide binding site [chemical binding]; other site 692420011184 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 692420011185 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 692420011186 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 692420011187 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 692420011188 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 692420011189 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 692420011190 tetramer interface [polypeptide binding]; other site 692420011191 heme binding pocket [chemical binding]; other site 692420011192 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 692420011193 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 692420011194 active site 692420011195 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 692420011196 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 692420011197 Na binding site [ion binding]; other site 692420011198 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 692420011199 putative ATP binding site [chemical binding]; other site 692420011200 putative substrate binding site [chemical binding]; other site 692420011201 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 692420011202 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 692420011203 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 692420011204 Walker A/P-loop; other site 692420011205 ATP binding site [chemical binding]; other site 692420011206 Q-loop/lid; other site 692420011207 ABC transporter signature motif; other site 692420011208 Walker B; other site 692420011209 D-loop; other site 692420011210 H-loop/switch region; other site 692420011211 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 692420011212 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 692420011213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420011214 ATP binding site [chemical binding]; other site 692420011215 Q-loop/lid; other site 692420011216 ABC transporter signature motif; other site 692420011217 Walker B; other site 692420011218 D-loop; other site 692420011219 H-loop/switch region; other site 692420011220 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 692420011221 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 692420011222 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 692420011223 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 692420011224 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 692420011225 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 692420011226 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 692420011227 putative active site [active] 692420011228 putative metal binding site [ion binding]; other site 692420011229 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 692420011230 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 692420011231 Walker A/P-loop; other site 692420011232 ATP binding site [chemical binding]; other site 692420011233 Q-loop/lid; other site 692420011234 ABC transporter signature motif; other site 692420011235 Walker B; other site 692420011236 D-loop; other site 692420011237 H-loop/switch region; other site 692420011238 TOBE domain; Region: TOBE; pfam03459 692420011239 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 692420011240 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 692420011241 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420011242 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420011243 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 692420011244 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 692420011245 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 692420011246 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 692420011247 UDP-glucose 4-epimerase; Region: PLN02240 692420011248 NAD binding site [chemical binding]; other site 692420011249 homodimer interface [polypeptide binding]; other site 692420011250 active site 692420011251 substrate binding site [chemical binding]; other site 692420011252 peptidase T; Region: peptidase-T; TIGR01882 692420011253 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 692420011254 metal binding site [ion binding]; metal-binding site 692420011255 dimer interface [polypeptide binding]; other site 692420011256 Tubby C 2; Region: Tub_2; cl02043 692420011257 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 692420011258 substrate binding site [chemical binding]; other site 692420011259 THF binding site; other site 692420011260 zinc-binding site [ion binding]; other site 692420011261 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 692420011262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420011263 S-adenosylmethionine binding site [chemical binding]; other site 692420011264 nucleoside transporter; Region: nupC; TIGR00804 692420011265 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 692420011266 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 692420011267 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 692420011268 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 692420011269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 692420011270 ABC transporter signature motif; other site 692420011271 Walker B; other site 692420011272 D-loop; other site 692420011273 H-loop/switch region; other site 692420011274 hydroperoxidase II; Provisional; Region: katE; PRK11249 692420011275 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 692420011276 tetramer interface [polypeptide binding]; other site 692420011277 heme binding pocket [chemical binding]; other site 692420011278 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 692420011279 domain interactions; other site 692420011280 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 692420011281 Citrate transporter; Region: CitMHS; pfam03600 692420011282 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 692420011283 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 692420011284 active site 692420011285 active site 692420011286 catalytic residues [active] 692420011287 transcriptional antiterminator BglG; Provisional; Region: PRK09772 692420011288 CAT RNA binding domain; Region: CAT_RBD; smart01061 692420011289 PRD domain; Region: PRD; pfam00874 692420011290 PRD domain; Region: PRD; pfam00874 692420011291 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 692420011292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420011293 putative substrate translocation pore; other site 692420011294 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 692420011295 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 692420011296 ATP binding site [chemical binding]; other site 692420011297 Mg++ binding site [ion binding]; other site 692420011298 motif III; other site 692420011299 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 692420011300 nucleotide binding region [chemical binding]; other site 692420011301 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 692420011302 RNA binding site [nucleotide binding]; other site 692420011303 YxiJ-like protein; Region: YxiJ; pfam14176 692420011304 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 692420011305 Amb_all domain; Region: Amb_all; smart00656 692420011306 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 692420011307 EamA-like transporter family; Region: EamA; pfam00892 692420011308 EamA-like transporter family; Region: EamA; pfam00892 692420011309 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 692420011310 Ligand Binding Site [chemical binding]; other site 692420011311 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 692420011312 beta-galactosidase; Region: BGL; TIGR03356 692420011313 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 692420011314 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 692420011315 active site turn [active] 692420011316 phosphorylation site [posttranslational modification] 692420011317 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 692420011318 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 692420011319 HPr interaction site; other site 692420011320 glycerol kinase (GK) interaction site [polypeptide binding]; other site 692420011321 active site 692420011322 phosphorylation site [posttranslational modification] 692420011323 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 692420011324 additional DNA contacts [nucleotide binding]; other site 692420011325 mismatch recognition site; other site 692420011326 active site 692420011327 zinc binding site [ion binding]; other site 692420011328 DNA intercalation site [nucleotide binding]; other site 692420011329 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 692420011330 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 692420011331 cofactor binding site; other site 692420011332 DNA binding site [nucleotide binding] 692420011333 substrate interaction site [chemical binding]; other site 692420011334 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 692420011335 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 692420011336 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 692420011337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420011338 ATP binding site [chemical binding]; other site 692420011339 G-X-G motif; other site 692420011340 Z1 domain; Region: Z1; pfam10593 692420011341 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 692420011342 AIPR protein; Region: AIPR; pfam10592 692420011343 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 692420011344 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 692420011345 substrate binding site [chemical binding]; other site 692420011346 active site 692420011347 anti-terminator HutP; Provisional; Region: hutP; PRK03065 692420011348 RNA binding site [nucleotide binding]; other site 692420011349 hexamer interface [polypeptide binding]; other site 692420011350 Histidine-zinc binding site [chemical binding]; other site 692420011351 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 692420011352 active sites [active] 692420011353 tetramer interface [polypeptide binding]; other site 692420011354 urocanate hydratase; Provisional; Region: PRK05414 692420011355 imidazolonepropionase; Validated; Region: PRK09356 692420011356 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 692420011357 active site 692420011358 Agmatinase-like family; Region: Agmatinase-like; cd09990 692420011359 agmatinase; Region: agmatinase; TIGR01230 692420011360 active site 692420011361 oligomer interface [polypeptide binding]; other site 692420011362 Mn binding site [ion binding]; other site 692420011363 S-methylmethionine transporter; Provisional; Region: PRK11387 692420011364 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 692420011365 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 692420011366 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 692420011367 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 692420011368 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 692420011369 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 692420011370 Nucleoside recognition; Region: Gate; pfam07670 692420011371 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 692420011372 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 692420011373 intersubunit interface [polypeptide binding]; other site 692420011374 active site 692420011375 catalytic residue [active] 692420011376 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 692420011377 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 692420011378 non-specific DNA interactions [nucleotide binding]; other site 692420011379 DNA binding site [nucleotide binding] 692420011380 sequence specific DNA binding site [nucleotide binding]; other site 692420011381 putative cAMP binding site [chemical binding]; other site 692420011382 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 692420011383 sugar phosphate phosphatase; Provisional; Region: PRK10513 692420011384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420011385 active site 692420011386 motif I; other site 692420011387 motif II; other site 692420011388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 692420011389 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 692420011390 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 692420011391 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 692420011392 putative ligand binding residues [chemical binding]; other site 692420011393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 692420011394 FtsX-like permease family; Region: FtsX; pfam02687 692420011395 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 692420011396 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 692420011397 Walker A/P-loop; other site 692420011398 ATP binding site [chemical binding]; other site 692420011399 Q-loop/lid; other site 692420011400 ABC transporter signature motif; other site 692420011401 Walker B; other site 692420011402 D-loop; other site 692420011403 H-loop/switch region; other site 692420011404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420011405 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 692420011406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420011407 ATP binding site [chemical binding]; other site 692420011408 Mg2+ binding site [ion binding]; other site 692420011409 G-X-G motif; other site 692420011410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420011411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420011412 active site 692420011413 phosphorylation site [posttranslational modification] 692420011414 intermolecular recognition site; other site 692420011415 dimerization interface [polypeptide binding]; other site 692420011416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420011417 DNA binding site [nucleotide binding] 692420011418 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 692420011419 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 692420011420 intersubunit interface [polypeptide binding]; other site 692420011421 active site 692420011422 zinc binding site [ion binding]; other site 692420011423 Na+ binding site [ion binding]; other site 692420011424 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 692420011425 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 692420011426 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 692420011427 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 692420011428 DNA interaction; other site 692420011429 Metal-binding active site; metal-binding site 692420011430 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 692420011431 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 692420011432 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 692420011433 Glucuronate isomerase; Region: UxaC; cl00829 692420011434 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420011435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420011436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420011437 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 692420011438 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 692420011439 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 692420011440 PYR/PP interface [polypeptide binding]; other site 692420011441 dimer interface [polypeptide binding]; other site 692420011442 TPP binding site [chemical binding]; other site 692420011443 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 692420011444 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 692420011445 TPP-binding site; other site 692420011446 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 692420011447 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 692420011448 substrate binding site [chemical binding]; other site 692420011449 ATP binding site [chemical binding]; other site 692420011450 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 692420011451 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 692420011452 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 692420011453 tetrameric interface [polypeptide binding]; other site 692420011454 NAD binding site [chemical binding]; other site 692420011455 catalytic residues [active] 692420011456 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 692420011457 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 692420011458 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 692420011459 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420011460 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420011461 active site 692420011462 catalytic tetrad [active] 692420011463 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 692420011464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420011465 putative substrate translocation pore; other site 692420011466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420011467 heat shock protein 90; Provisional; Region: PRK05218 692420011468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420011469 ATP binding site [chemical binding]; other site 692420011470 Mg2+ binding site [ion binding]; other site 692420011471 G-X-G motif; other site 692420011472 short chain dehydrogenase; Validated; Region: PRK08589 692420011473 classical (c) SDRs; Region: SDR_c; cd05233 692420011474 NAD(P) binding site [chemical binding]; other site 692420011475 active site 692420011476 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 692420011477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420011478 active site 692420011479 phosphorylation site [posttranslational modification] 692420011480 intermolecular recognition site; other site 692420011481 dimerization interface [polypeptide binding]; other site 692420011482 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 692420011483 DNA binding residues [nucleotide binding] 692420011484 dimerization interface [polypeptide binding]; other site 692420011485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 692420011486 Histidine kinase; Region: HisKA_3; pfam07730 692420011487 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 692420011488 ATP binding site [chemical binding]; other site 692420011489 Mg2+ binding site [ion binding]; other site 692420011490 G-X-G motif; other site 692420011491 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 692420011492 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 692420011493 putative di-iron ligands [ion binding]; other site 692420011494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420011495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420011496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 692420011497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 692420011498 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 692420011499 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 692420011500 NAD(P) binding site [chemical binding]; other site 692420011501 catalytic residues [active] 692420011502 FOG: WD40-like repeat [Function unknown]; Region: COG1520 692420011503 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 692420011504 Trp docking motif [polypeptide binding]; other site 692420011505 active site 692420011506 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420011507 putative DNA binding site [nucleotide binding]; other site 692420011508 dimerization interface [polypeptide binding]; other site 692420011509 putative Zn2+ binding site [ion binding]; other site 692420011510 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 692420011511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420011512 putative substrate translocation pore; other site 692420011513 RDD family; Region: RDD; pfam06271 692420011514 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 692420011515 peroxiredoxin; Region: AhpC; TIGR03137 692420011516 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 692420011517 dimer interface [polypeptide binding]; other site 692420011518 decamer (pentamer of dimers) interface [polypeptide binding]; other site 692420011519 catalytic triad [active] 692420011520 peroxidatic and resolving cysteines [active] 692420011521 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 692420011522 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 692420011523 catalytic residue [active] 692420011524 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 692420011525 catalytic residues [active] 692420011526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 692420011527 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 692420011528 Major royal jelly protein; Region: MRJP; pfam03022 692420011529 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 692420011530 HTH domain; Region: HTH_11; pfam08279 692420011531 WYL domain; Region: WYL; pfam13280 692420011532 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 692420011533 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 692420011534 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 692420011535 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 692420011536 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 692420011537 catalytic residues [active] 692420011538 catalytic nucleophile [active] 692420011539 Presynaptic Site I dimer interface [polypeptide binding]; other site 692420011540 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 692420011541 Synaptic Flat tetramer interface [polypeptide binding]; other site 692420011542 Synaptic Site I dimer interface [polypeptide binding]; other site 692420011543 DNA binding site [nucleotide binding] 692420011544 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 692420011545 DNA-binding interface [nucleotide binding]; DNA binding site 692420011546 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 692420011547 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 692420011548 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 692420011549 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 692420011550 stage V sporulation protein AD; Provisional; Region: PRK12404 692420011551 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 692420011552 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 692420011553 Predicted membrane protein [Function unknown]; Region: COG2323 692420011554 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 692420011555 Predicted membrane protein [Function unknown]; Region: COG2323 692420011556 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 692420011557 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 692420011558 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 692420011559 putative active site [active] 692420011560 catalytic site [active] 692420011561 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 692420011562 putative active site [active] 692420011563 catalytic site [active] 692420011564 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 692420011565 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 692420011566 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 692420011567 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 692420011568 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 692420011569 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 692420011570 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 692420011571 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 692420011572 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 692420011573 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 692420011574 Ligand binding site; other site 692420011575 metal-binding site 692420011576 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 692420011577 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 692420011578 XdhC Rossmann domain; Region: XdhC_C; pfam13478 692420011579 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 692420011580 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 692420011581 Part of AAA domain; Region: AAA_19; pfam13245 692420011582 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 692420011583 putative active site [active] 692420011584 putative metal-binding site [ion binding]; other site 692420011585 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 692420011586 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 692420011587 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 692420011588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 692420011589 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 692420011590 active site 692420011591 catalytic tetrad [active] 692420011592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 692420011593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420011594 Coenzyme A binding pocket [chemical binding]; other site 692420011595 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420011596 Tetratricopeptide repeat; Region: TPR_12; pfam13424 692420011597 Arginase family; Region: Arginase; cd09989 692420011598 agmatinase; Region: agmatinase; TIGR01230 692420011599 active site 692420011600 Mn binding site [ion binding]; other site 692420011601 oligomer interface [polypeptide binding]; other site 692420011602 S-methylmethionine transporter; Provisional; Region: PRK11387 692420011603 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 692420011604 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 692420011605 inhibitor-cofactor binding pocket; inhibition site 692420011606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 692420011607 catalytic residue [active] 692420011608 Predicted integral membrane protein [Function unknown]; Region: COG5658 692420011609 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 692420011610 SdpI/YhfL protein family; Region: SdpI; pfam13630 692420011611 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420011612 dimerization interface [polypeptide binding]; other site 692420011613 putative DNA binding site [nucleotide binding]; other site 692420011614 putative Zn2+ binding site [ion binding]; other site 692420011615 PAS domain; Region: PAS_9; pfam13426 692420011616 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 692420011617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 692420011618 Walker A motif; other site 692420011619 ATP binding site [chemical binding]; other site 692420011620 Walker B motif; other site 692420011621 arginine finger; other site 692420011622 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 692420011623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420011624 putative substrate translocation pore; other site 692420011625 Major Facilitator Superfamily; Region: MFS_1; pfam07690 692420011626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 692420011627 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420011628 dimerization interface [polypeptide binding]; other site 692420011629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420011630 dimer interface [polypeptide binding]; other site 692420011631 phosphorylation site [posttranslational modification] 692420011632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420011633 ATP binding site [chemical binding]; other site 692420011634 Mg2+ binding site [ion binding]; other site 692420011635 G-X-G motif; other site 692420011636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420011637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420011638 active site 692420011639 phosphorylation site [posttranslational modification] 692420011640 intermolecular recognition site; other site 692420011641 dimerization interface [polypeptide binding]; other site 692420011642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420011643 DNA binding site [nucleotide binding] 692420011644 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 692420011645 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 692420011646 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 692420011647 Predicted membrane protein [Function unknown]; Region: COG3212 692420011648 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 692420011649 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 692420011650 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 692420011651 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 692420011652 protein binding site [polypeptide binding]; other site 692420011653 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 692420011654 YycH protein; Region: YycI; cl02015 692420011655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 692420011656 YycH protein; Region: YycH; pfam07435 692420011657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 692420011658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 692420011659 dimerization interface [polypeptide binding]; other site 692420011660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 692420011661 putative active site [active] 692420011662 heme pocket [chemical binding]; other site 692420011663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 692420011664 dimer interface [polypeptide binding]; other site 692420011665 phosphorylation site [posttranslational modification] 692420011666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 692420011667 ATP binding site [chemical binding]; other site 692420011668 Mg2+ binding site [ion binding]; other site 692420011669 G-X-G motif; other site 692420011670 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 692420011671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 692420011672 active site 692420011673 phosphorylation site [posttranslational modification] 692420011674 intermolecular recognition site; other site 692420011675 dimerization interface [polypeptide binding]; other site 692420011676 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 692420011677 DNA binding site [nucleotide binding] 692420011678 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 692420011679 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 692420011680 GDP-binding site [chemical binding]; other site 692420011681 ACT binding site; other site 692420011682 IMP binding site; other site 692420011683 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420011684 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 692420011685 active site 692420011686 replicative DNA helicase; Provisional; Region: PRK05748 692420011687 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 692420011688 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 692420011689 Walker A motif; other site 692420011690 ATP binding site [chemical binding]; other site 692420011691 Walker B motif; other site 692420011692 DNA binding loops [nucleotide binding] 692420011693 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 692420011694 YycC-like protein; Region: YycC; pfam14174 692420011695 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 692420011696 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 692420011697 Phosphotransferase enzyme family; Region: APH; pfam01636 692420011698 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 692420011699 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 692420011700 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 692420011701 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 692420011702 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 692420011703 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 692420011704 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 692420011705 active site 692420011706 substrate binding site [chemical binding]; other site 692420011707 ATP binding site [chemical binding]; other site 692420011708 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 692420011709 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 692420011710 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 692420011711 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 692420011712 diguanylate cyclase; Region: GGDEF; smart00267 692420011713 DHH family; Region: DHH; pfam01368 692420011714 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 692420011715 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 692420011716 Predicted transcriptional regulators [Transcription]; Region: COG1733 692420011717 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 692420011718 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 692420011719 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 692420011720 DHHA2 domain; Region: DHHA2; pfam02833 692420011721 EamA-like transporter family; Region: EamA; pfam00892 692420011722 EamA-like transporter family; Region: EamA; pfam00892 692420011723 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 692420011724 active site 692420011725 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 692420011726 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 692420011727 substrate binding [chemical binding]; other site 692420011728 active site 692420011729 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 692420011730 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 692420011731 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 692420011732 DNA-binding site [nucleotide binding]; DNA binding site 692420011733 FCD domain; Region: FCD; pfam07729 692420011734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 692420011735 H+ Antiporter protein; Region: 2A0121; TIGR00900 692420011736 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 692420011737 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 692420011738 dimer interface [polypeptide binding]; other site 692420011739 FMN binding site [chemical binding]; other site 692420011740 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420011741 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 692420011742 putative DNA binding site [nucleotide binding]; other site 692420011743 putative Zn2+ binding site [ion binding]; other site 692420011744 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 692420011745 Uncharacterized conserved protein [Function unknown]; Region: COG1284 692420011746 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 692420011747 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 692420011748 MarR family; Region: MarR; pfam01047 692420011749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420011750 Coenzyme A binding pocket [chemical binding]; other site 692420011751 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 692420011752 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 692420011753 TAP-like protein; Region: Abhydrolase_4; pfam08386 692420011754 potential frameshift: common BLAST hit: gi|154688185|ref|YP_001423346.1| YyaL 692420011755 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 692420011756 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 692420011757 catalytic residues [active] 692420011758 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 692420011759 CAAX protease self-immunity; Region: Abi; pfam02517 692420011760 benzoate transport; Region: 2A0115; TIGR00895 692420011761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420011762 putative substrate translocation pore; other site 692420011763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 692420011764 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 692420011765 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 692420011766 putative metal binding site [ion binding]; other site 692420011767 potential frameshift: common BLAST hit: gi|154688189|ref|YP_001423350.1| CcpB 692420011768 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 692420011769 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420011770 Transcriptional regulators [Transcription]; Region: PurR; COG1609 692420011771 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 692420011772 DNA binding site [nucleotide binding] 692420011773 domain linker motif; other site 692420011774 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 692420011775 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 692420011776 active site 692420011777 putative catalytic site [active] 692420011778 DNA binding site [nucleotide binding] 692420011779 putative phosphate binding site [ion binding]; other site 692420011780 metal binding site A [ion binding]; metal-binding site 692420011781 AP binding site [nucleotide binding]; other site 692420011782 metal binding site B [ion binding]; metal-binding site 692420011783 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 692420011784 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 692420011785 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 692420011786 DNA binding site [nucleotide binding] 692420011787 active site 692420011788 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 692420011789 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 692420011790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420011791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 692420011792 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 692420011793 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 692420011794 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 692420011795 dimer interface [polypeptide binding]; other site 692420011796 ssDNA binding site [nucleotide binding]; other site 692420011797 tetramer (dimer of dimers) interface [polypeptide binding]; other site 692420011798 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 692420011799 GTP-binding protein YchF; Reviewed; Region: PRK09601 692420011800 YchF GTPase; Region: YchF; cd01900 692420011801 G1 box; other site 692420011802 GTP/Mg2+ binding site [chemical binding]; other site 692420011803 Switch I region; other site 692420011804 G2 box; other site 692420011805 Switch II region; other site 692420011806 G3 box; other site 692420011807 G4 box; other site 692420011808 G5 box; other site 692420011809 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 692420011810 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 692420011811 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 692420011812 putative [4Fe-4S] binding site [ion binding]; other site 692420011813 putative molybdopterin cofactor binding site [chemical binding]; other site 692420011814 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 692420011815 molybdopterin cofactor binding site; other site 692420011816 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 692420011817 Uncharacterized membrane protein [Function unknown]; Region: COG3949 692420011818 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 692420011819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 692420011820 Coenzyme A binding pocket [chemical binding]; other site 692420011821 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 692420011822 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 692420011823 ParB-like nuclease domain; Region: ParB; smart00470 692420011824 KorB domain; Region: KorB; pfam08535 692420011825 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 692420011826 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 692420011827 P-loop; other site 692420011828 Magnesium ion binding site [ion binding]; other site 692420011829 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 692420011830 Magnesium ion binding site [ion binding]; other site 692420011831 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 692420011832 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 692420011833 ParB-like nuclease domain; Region: ParB; smart00470 692420011834 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 692420011835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 692420011836 S-adenosylmethionine binding site [chemical binding]; other site 692420011837 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 692420011838 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 692420011839 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 692420011840 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 692420011841 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 692420011842 trmE is a tRNA modification GTPase; Region: trmE; cd04164 692420011843 G1 box; other site 692420011844 GTP/Mg2+ binding site [chemical binding]; other site 692420011845 Switch I region; other site 692420011846 G2 box; other site 692420011847 Switch II region; other site 692420011848 G3 box; other site 692420011849 G4 box; other site 692420011850 G5 box; other site 692420011851 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 692420011852 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 692420011853 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 692420011854 G-X-X-G motif; other site 692420011855 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 692420011856 RxxxH motif; other site 692420011857 OxaA-like protein precursor; Validated; Region: PRK02944 692420011858 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 692420011859 ribonuclease P; Reviewed; Region: rnpA; PRK00499 692420011860 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399