-- dump date 20140618_210137 -- class Genbank::misc_feature -- table misc_feature_note -- id note 137722000001 PEP synthetase regulatory protein; Provisional; Region: PRK05339 137722000002 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 137722000003 active site 137722000004 dimer interface [polypeptide binding]; other site 137722000005 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 137722000006 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 137722000007 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 137722000008 NAD(P) binding site [chemical binding]; other site 137722000009 shikimate binding site; other site 137722000010 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 137722000011 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 137722000012 CoA-binding site [chemical binding]; other site 137722000013 ATP-binding [chemical binding]; other site 137722000014 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 137722000015 active site 137722000016 catalytic site [active] 137722000017 substrate binding site [chemical binding]; other site 137722000018 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 137722000019 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 137722000020 NADP binding site [chemical binding]; other site 137722000021 dimer interface [polypeptide binding]; other site 137722000022 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 137722000023 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 137722000024 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 137722000025 DNA binding site [nucleotide binding] 137722000026 active site 137722000027 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 137722000028 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 137722000029 catalytic residues [active] 137722000030 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 137722000031 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 137722000032 dimer interface [polypeptide binding]; other site 137722000033 [2Fe-2S] cluster binding site [ion binding]; other site 137722000034 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 137722000035 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 137722000036 trmE is a tRNA modification GTPase; Region: trmE; cd04164 137722000037 G1 box; other site 137722000038 GTP/Mg2+ binding site [chemical binding]; other site 137722000039 Switch I region; other site 137722000040 G2 box; other site 137722000041 Switch II region; other site 137722000042 G3 box; other site 137722000043 G4 box; other site 137722000044 G5 box; other site 137722000045 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 137722000046 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 137722000047 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 137722000048 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 137722000049 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 137722000050 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 137722000051 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 137722000052 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 137722000053 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722000054 Magnesium ion binding site [ion binding]; other site 137722000055 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 137722000056 ParB-like nuclease domain; Region: ParB; smart00470 137722000057 KorB domain; Region: KorB; pfam08535 137722000058 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 137722000059 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 137722000060 folate binding site [chemical binding]; other site 137722000061 NADP+ binding site [chemical binding]; other site 137722000062 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 137722000063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722000064 FeS/SAM binding site; other site 137722000065 HemN C-terminal domain; Region: HemN_C; pfam06969 137722000066 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 137722000067 active site 137722000068 dimerization interface [polypeptide binding]; other site 137722000069 ribonuclease PH; Reviewed; Region: rph; PRK00173 137722000070 Ribonuclease PH; Region: RNase_PH_bact; cd11362 137722000071 hexamer interface [polypeptide binding]; other site 137722000072 active site 137722000073 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 137722000074 Malic enzyme, N-terminal domain; Region: malic; pfam00390 137722000075 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 137722000076 putative NAD(P) binding site [chemical binding]; other site 137722000077 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 137722000078 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 137722000079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722000080 sequence-specific DNA binding site [nucleotide binding]; other site 137722000081 salt bridge; other site 137722000082 Cupin domain; Region: Cupin_2; pfam07883 137722000083 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722000084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722000085 dimer interface [polypeptide binding]; other site 137722000086 phosphorylation site [posttranslational modification] 137722000087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722000088 ATP binding site [chemical binding]; other site 137722000089 Mg2+ binding site [ion binding]; other site 137722000090 G-X-G motif; other site 137722000091 PBP superfamily domain; Region: PBP_like_2; cl17296 137722000092 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 137722000093 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 137722000094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722000095 dimer interface [polypeptide binding]; other site 137722000096 conserved gate region; other site 137722000097 putative PBP binding loops; other site 137722000098 ABC-ATPase subunit interface; other site 137722000099 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 137722000100 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 137722000101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722000102 dimer interface [polypeptide binding]; other site 137722000103 conserved gate region; other site 137722000104 putative PBP binding loops; other site 137722000105 ABC-ATPase subunit interface; other site 137722000106 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 137722000107 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 137722000108 Walker A/P-loop; other site 137722000109 ATP binding site [chemical binding]; other site 137722000110 Q-loop/lid; other site 137722000111 ABC transporter signature motif; other site 137722000112 Walker B; other site 137722000113 D-loop; other site 137722000114 H-loop/switch region; other site 137722000115 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 137722000116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722000117 active site 137722000118 phosphorylation site [posttranslational modification] 137722000119 intermolecular recognition site; other site 137722000120 dimerization interface [polypeptide binding]; other site 137722000121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722000122 DNA binding site [nucleotide binding] 137722000123 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 137722000124 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 137722000125 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 137722000126 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 137722000127 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 137722000128 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 137722000129 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 137722000130 Walker A/P-loop; other site 137722000131 ATP binding site [chemical binding]; other site 137722000132 Q-loop/lid; other site 137722000133 ABC transporter signature motif; other site 137722000134 Walker B; other site 137722000135 D-loop; other site 137722000136 H-loop/switch region; other site 137722000137 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 137722000138 active site 137722000139 catalytic triad [active] 137722000140 oxyanion hole [active] 137722000141 switch loop; other site 137722000142 FIST N domain; Region: FIST; pfam08495 137722000143 FIST C domain; Region: FIST_C; pfam10442 137722000144 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 137722000145 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 137722000146 active site 137722000147 catalytic tetrad [active] 137722000148 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 137722000149 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 137722000150 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 137722000151 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 137722000152 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 137722000153 putative NAD(P) binding site [chemical binding]; other site 137722000154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722000155 salt bridge; other site 137722000156 non-specific DNA binding site [nucleotide binding]; other site 137722000157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722000158 sequence-specific DNA binding site [nucleotide binding]; other site 137722000159 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722000160 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722000161 metal binding site [ion binding]; metal-binding site 137722000162 active site 137722000163 I-site; other site 137722000164 chaperone protein DnaJ; Provisional; Region: PRK10767 137722000165 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 137722000166 HSP70 interaction site [polypeptide binding]; other site 137722000167 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 137722000168 substrate binding site [polypeptide binding]; other site 137722000169 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 137722000170 Zn binding sites [ion binding]; other site 137722000171 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 137722000172 dimer interface [polypeptide binding]; other site 137722000173 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 137722000174 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 137722000175 nucleotide binding site [chemical binding]; other site 137722000176 NEF interaction site [polypeptide binding]; other site 137722000177 SBD interface [polypeptide binding]; other site 137722000178 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 137722000179 putative active site [active] 137722000180 putative metal binding site [ion binding]; other site 137722000181 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 137722000182 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 137722000183 Glycoprotease family; Region: Peptidase_M22; pfam00814 137722000184 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 137722000185 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 137722000186 CPxP motif; other site 137722000187 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 137722000188 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 137722000189 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 137722000190 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 137722000191 putative acyl-acceptor binding pocket; other site 137722000192 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722000193 active site 137722000194 DNA binding site [nucleotide binding] 137722000195 Int/Topo IB signature motif; other site 137722000196 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722000197 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722000198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722000199 Integrase core domain; Region: rve; pfam00665 137722000200 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722000201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722000202 Walker A motif; other site 137722000203 ATP binding site [chemical binding]; other site 137722000204 Replication protein C (RepC); Region: RepC; pfam06504 137722000205 Replication initiator protein A; Region: RPA; cl17860 137722000206 AAA domain; Region: AAA_25; pfam13481 137722000207 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 137722000208 Walker A motif; other site 137722000209 ATP binding site [chemical binding]; other site 137722000210 Walker B motif; other site 137722000211 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 137722000212 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 137722000213 active site 137722000214 substrate-binding site [chemical binding]; other site 137722000215 metal-binding site [ion binding] 137722000216 GTP binding site [chemical binding]; other site 137722000217 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 137722000218 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 137722000219 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 137722000220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722000221 active site 137722000222 phosphorylation site [posttranslational modification] 137722000223 intermolecular recognition site; other site 137722000224 dimerization interface [polypeptide binding]; other site 137722000225 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722000226 DNA binding site [nucleotide binding] 137722000227 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 137722000228 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 137722000229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722000230 HAMP domain; Region: HAMP; pfam00672 137722000231 dimerization interface [polypeptide binding]; other site 137722000232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722000233 dimer interface [polypeptide binding]; other site 137722000234 phosphorylation site [posttranslational modification] 137722000235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722000236 ATP binding site [chemical binding]; other site 137722000237 Mg2+ binding site [ion binding]; other site 137722000238 G-X-G motif; other site 137722000239 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 137722000240 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 137722000241 Hpr binding site; other site 137722000242 active site 137722000243 homohexamer subunit interaction site [polypeptide binding]; other site 137722000244 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 137722000245 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 137722000246 active pocket/dimerization site; other site 137722000247 active site 137722000248 phosphorylation site [posttranslational modification] 137722000249 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 137722000250 dimerization domain swap beta strand [polypeptide binding]; other site 137722000251 regulatory protein interface [polypeptide binding]; other site 137722000252 active site 137722000253 regulatory phosphorylation site [posttranslational modification]; other site 137722000254 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 137722000255 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 137722000256 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 137722000257 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 137722000258 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 137722000259 Cytochrome c; Region: Cytochrom_C; pfam00034 137722000260 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 137722000261 Catalytic site; other site 137722000262 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 137722000263 dimerization interface [polypeptide binding]; other site 137722000264 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 137722000265 cyclase homology domain; Region: CHD; cd07302 137722000266 nucleotidyl binding site; other site 137722000267 metal binding site [ion binding]; metal-binding site 137722000268 dimer interface [polypeptide binding]; other site 137722000269 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 137722000270 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 137722000271 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 137722000272 metal ion-dependent adhesion site (MIDAS); other site 137722000273 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 137722000274 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 137722000275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 137722000276 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 137722000277 HSP70 interaction site [polypeptide binding]; other site 137722000278 BolA-like protein; Region: BolA; pfam01722 137722000279 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 137722000280 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 137722000281 FOG: CBS domain [General function prediction only]; Region: COG0517 137722000282 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 137722000283 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 137722000284 putative hydrophobic ligand binding site [chemical binding]; other site 137722000285 protein interface [polypeptide binding]; other site 137722000286 gate; other site 137722000287 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 137722000288 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 137722000289 active site 137722000290 dimer interface [polypeptide binding]; other site 137722000291 metal binding site [ion binding]; metal-binding site 137722000292 shikimate kinase; Provisional; Region: PRK13946 137722000293 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 137722000294 ADP binding site [chemical binding]; other site 137722000295 magnesium binding site [ion binding]; other site 137722000296 putative shikimate binding site; other site 137722000297 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 137722000298 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722000299 active site 137722000300 DNA binding site [nucleotide binding] 137722000301 Int/Topo IB signature motif; other site 137722000302 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 137722000303 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 137722000304 aromatic arch; other site 137722000305 DCoH dimer interaction site [polypeptide binding]; other site 137722000306 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 137722000307 DCoH tetramer interaction site [polypeptide binding]; other site 137722000308 substrate binding site [chemical binding]; other site 137722000309 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 137722000310 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 137722000311 putative uracil binding site [chemical binding]; other site 137722000312 putative active site [active] 137722000313 NAD-dependent deacetylase; Provisional; Region: PRK00481 137722000314 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 137722000315 NAD+ binding site [chemical binding]; other site 137722000316 substrate binding site [chemical binding]; other site 137722000317 Zn binding site [ion binding]; other site 137722000318 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 137722000319 Low molecular weight phosphatase family; Region: LMWPc; cd00115 137722000320 active site 137722000321 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722000322 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722000323 ligand binding site [chemical binding]; other site 137722000324 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722000325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722000326 dimer interface [polypeptide binding]; other site 137722000327 phosphorylation site [posttranslational modification] 137722000328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722000329 ATP binding site [chemical binding]; other site 137722000330 G-X-G motif; other site 137722000331 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 137722000332 FliG C-terminal domain; Region: FliG_C; pfam01706 137722000333 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 137722000334 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 137722000335 interface (dimer of trimers) [polypeptide binding]; other site 137722000336 Substrate-binding/catalytic site; other site 137722000337 Zn-binding sites [ion binding]; other site 137722000338 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722000339 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722000340 metal binding site [ion binding]; metal-binding site 137722000341 active site 137722000342 I-site; other site 137722000343 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 137722000344 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 137722000345 putative C-terminal domain interface [polypeptide binding]; other site 137722000346 putative GSH binding site (G-site) [chemical binding]; other site 137722000347 putative dimer interface [polypeptide binding]; other site 137722000348 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 137722000349 putative substrate binding pocket (H-site) [chemical binding]; other site 137722000350 putative N-terminal domain interface [polypeptide binding]; other site 137722000351 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 137722000352 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 137722000353 active site 137722000354 dimer interface [polypeptide binding]; other site 137722000355 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 137722000356 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 137722000357 active site 137722000358 FMN binding site [chemical binding]; other site 137722000359 substrate binding site [chemical binding]; other site 137722000360 3Fe-4S cluster binding site [ion binding]; other site 137722000361 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 137722000362 domain interface; other site 137722000363 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 137722000364 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 137722000365 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 137722000366 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 137722000367 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 137722000368 putative NAD(P) binding site [chemical binding]; other site 137722000369 active site 137722000370 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 137722000371 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 137722000372 catalytic site [active] 137722000373 putative active site [active] 137722000374 putative substrate binding site [chemical binding]; other site 137722000375 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 137722000376 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 137722000377 putative active site [active] 137722000378 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 137722000379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 137722000380 OstA-like protein; Region: OstA; cl00844 137722000381 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 137722000382 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 137722000383 Walker A/P-loop; other site 137722000384 ATP binding site [chemical binding]; other site 137722000385 Q-loop/lid; other site 137722000386 ABC transporter signature motif; other site 137722000387 Walker B; other site 137722000388 D-loop; other site 137722000389 H-loop/switch region; other site 137722000390 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 137722000391 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 137722000392 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 137722000393 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 137722000394 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 137722000395 30S subunit binding site; other site 137722000396 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 137722000397 active site 137722000398 phosphorylation site [posttranslational modification] 137722000399 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 137722000400 putative active site [active] 137722000401 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 137722000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722000403 S-adenosylmethionine binding site [chemical binding]; other site 137722000404 aspartate kinase; Reviewed; Region: PRK06635 137722000405 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 137722000406 putative nucleotide binding site [chemical binding]; other site 137722000407 putative catalytic residues [active] 137722000408 putative Mg ion binding site [ion binding]; other site 137722000409 putative aspartate binding site [chemical binding]; other site 137722000410 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 137722000411 putative allosteric regulatory site; other site 137722000412 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 137722000413 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 137722000414 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 137722000415 FMN binding site [chemical binding]; other site 137722000416 substrate binding site [chemical binding]; other site 137722000417 putative catalytic residue [active] 137722000418 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 137722000419 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 137722000420 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 137722000421 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 137722000422 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 137722000423 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 137722000424 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 137722000425 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 137722000426 active site residue [active] 137722000427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722000428 binding surface 137722000429 TPR motif; other site 137722000430 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 137722000431 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 137722000432 ligand binding site [chemical binding]; other site 137722000433 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722000434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722000435 Walker A motif; other site 137722000436 ATP binding site [chemical binding]; other site 137722000437 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722000438 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722000439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722000440 Integrase core domain; Region: rve; pfam00665 137722000441 PBP superfamily domain; Region: PBP_like_2; cl17296 137722000442 Tubulin like; Region: Tubulin_2; pfam13809 137722000443 Flp/Fap pilin component; Region: Flp_Fap; cl01585 137722000444 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 137722000445 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 137722000446 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 137722000447 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 137722000448 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 137722000449 Type IV pili component [Cell motility and secretion]; Region: COG5461 137722000450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 137722000451 active site 137722000452 phosphorylation site [posttranslational modification] 137722000453 intermolecular recognition site; other site 137722000454 dimerization interface [polypeptide binding]; other site 137722000455 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 137722000456 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 137722000457 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 137722000458 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 137722000459 ATP binding site [chemical binding]; other site 137722000460 Walker A motif; other site 137722000461 hexamer interface [polypeptide binding]; other site 137722000462 Walker B motif; other site 137722000463 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 137722000464 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 137722000465 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 137722000466 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 137722000467 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 137722000468 TadE-like protein; Region: TadE; pfam07811 137722000469 TadE-like protein; Region: TadE; pfam07811 137722000470 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 137722000471 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 137722000472 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 137722000473 Helix-turn-helix domain; Region: HTH_25; pfam13413 137722000474 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 137722000475 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 137722000476 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 137722000477 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 137722000478 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 137722000479 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 137722000480 NAD(P) binding pocket [chemical binding]; other site 137722000481 peptide chain release factor 1; Validated; Region: prfA; PRK00591 137722000482 This domain is found in peptide chain release factors; Region: PCRF; smart00937 137722000483 RF-1 domain; Region: RF-1; pfam00472 137722000484 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 137722000485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722000486 S-adenosylmethionine binding site [chemical binding]; other site 137722000487 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 137722000488 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 137722000489 MOSC domain; Region: MOSC; pfam03473 137722000490 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 137722000491 nudix motif; other site 137722000492 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 137722000493 Clp amino terminal domain; Region: Clp_N; pfam02861 137722000494 Clp amino terminal domain; Region: Clp_N; pfam02861 137722000495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722000496 Walker A motif; other site 137722000497 ATP binding site [chemical binding]; other site 137722000498 Walker B motif; other site 137722000499 arginine finger; other site 137722000500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722000501 Walker A motif; other site 137722000502 ATP binding site [chemical binding]; other site 137722000503 Walker B motif; other site 137722000504 arginine finger; other site 137722000505 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 137722000506 Methyltransferase domain; Region: Methyltransf_31; pfam13847 137722000507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722000508 S-adenosylmethionine binding site [chemical binding]; other site 137722000509 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 137722000510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722000511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722000512 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 137722000513 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 137722000514 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 137722000515 Protein of unknown function, DUF485; Region: DUF485; pfam04341 137722000516 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 137722000517 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 137722000518 Na binding site [ion binding]; other site 137722000519 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 137722000520 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722000521 ligand binding site [chemical binding]; other site 137722000522 flexible hinge region; other site 137722000523 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 137722000524 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 137722000525 metal binding triad; other site 137722000526 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 137722000527 nitrilase; Region: PLN02798 137722000528 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 137722000529 putative active site [active] 137722000530 catalytic triad [active] 137722000531 dimer interface [polypeptide binding]; other site 137722000532 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 137722000533 GSH binding site [chemical binding]; other site 137722000534 catalytic residues [active] 137722000535 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 137722000536 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 137722000537 active site 137722000538 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 137722000539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722000540 S-adenosylmethionine binding site [chemical binding]; other site 137722000541 Family description; Region: DsbD_2; pfam13386 137722000542 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 137722000543 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 137722000544 Ligand Binding Site [chemical binding]; other site 137722000545 PAS fold; Region: PAS_4; pfam08448 137722000546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722000547 putative active site [active] 137722000548 heme pocket [chemical binding]; other site 137722000549 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722000550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722000551 metal binding site [ion binding]; metal-binding site 137722000552 active site 137722000553 I-site; other site 137722000554 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722000555 PrcB C-terminal; Region: PrcB_C; pfam14343 137722000556 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 137722000557 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 137722000558 metal binding site [ion binding]; metal-binding site 137722000559 putative dimer interface [polypeptide binding]; other site 137722000560 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 137722000561 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 137722000562 C-terminal domain interface [polypeptide binding]; other site 137722000563 GSH binding site (G-site) [chemical binding]; other site 137722000564 dimer interface [polypeptide binding]; other site 137722000565 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 137722000566 N-terminal domain interface [polypeptide binding]; other site 137722000567 dimer interface [polypeptide binding]; other site 137722000568 substrate binding pocket (H-site) [chemical binding]; other site 137722000569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 137722000570 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 137722000571 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 137722000572 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 137722000573 Zn2+ binding site [ion binding]; other site 137722000574 Mg2+ binding site [ion binding]; other site 137722000575 Response regulator receiver domain; Region: Response_reg; pfam00072 137722000576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722000577 active site 137722000578 phosphorylation site [posttranslational modification] 137722000579 intermolecular recognition site; other site 137722000580 dimerization interface [polypeptide binding]; other site 137722000581 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 137722000582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722000583 FeS/SAM binding site; other site 137722000584 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 137722000585 Iron-sulfur protein interface; other site 137722000586 proximal quinone binding site [chemical binding]; other site 137722000587 SdhD (CybS) interface [polypeptide binding]; other site 137722000588 proximal heme binding site [chemical binding]; other site 137722000589 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 137722000590 putative SdhC subunit interface [polypeptide binding]; other site 137722000591 putative proximal heme binding site [chemical binding]; other site 137722000592 putative Iron-sulfur protein interface [polypeptide binding]; other site 137722000593 putative proximal quinone binding site; other site 137722000594 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 137722000595 L-aspartate oxidase; Provisional; Region: PRK06175 137722000596 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 137722000597 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 137722000598 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 137722000599 aminotransferase; Provisional; Region: PRK13356 137722000600 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 137722000601 homodimer interface [polypeptide binding]; other site 137722000602 substrate-cofactor binding pocket; other site 137722000603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722000604 catalytic residue [active] 137722000605 Predicted transcriptional regulator [Transcription]; Region: COG2932 137722000606 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 137722000607 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 137722000608 Catalytic site [active] 137722000609 hypothetical protein; Region: PHA00670 137722000610 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 137722000611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722000612 PAS domain; Region: PAS_9; pfam13426 137722000613 putative active site [active] 137722000614 heme pocket [chemical binding]; other site 137722000615 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722000616 metal binding site [ion binding]; metal-binding site 137722000617 active site 137722000618 I-site; other site 137722000619 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722000620 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 137722000621 putative active site [active] 137722000622 putative metal binding site [ion binding]; other site 137722000623 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 137722000624 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 137722000625 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 137722000626 cytochrome c-550; Provisional; Region: psbV; cl17239 137722000627 Cytochrome C' Region: Cytochrom_C_2; pfam01322 137722000628 aspartate aminotransferase; Provisional; Region: PRK05764 137722000629 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722000630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722000631 homodimer interface [polypeptide binding]; other site 137722000632 catalytic residue [active] 137722000633 Predicted flavoprotein [General function prediction only]; Region: COG0431 137722000634 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 137722000635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722000636 NAD(P) binding site [chemical binding]; other site 137722000637 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 137722000638 active site 137722000639 Uncharacterized conserved protein [Function unknown]; Region: COG3339 137722000640 EamA-like transporter family; Region: EamA; pfam00892 137722000641 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 137722000642 ornithine cyclodeaminase; Validated; Region: PRK06141 137722000643 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 137722000644 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 137722000645 IHF dimer interface [polypeptide binding]; other site 137722000646 IHF - DNA interface [nucleotide binding]; other site 137722000647 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722000648 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 137722000649 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722000650 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 137722000651 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722000652 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722000653 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722000654 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 137722000655 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722000656 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 137722000657 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 137722000658 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 137722000659 protein binding site [polypeptide binding]; other site 137722000660 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 137722000661 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 137722000662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 137722000663 Histidine kinase; Region: HisKA_2; pfam07568 137722000664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722000665 ATP binding site [chemical binding]; other site 137722000666 Mg2+ binding site [ion binding]; other site 137722000667 G-X-G motif; other site 137722000668 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 137722000669 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 137722000670 dimerization interface [polypeptide binding]; other site 137722000671 DPS ferroxidase diiron center [ion binding]; other site 137722000672 ion pore; other site 137722000673 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722000674 dimer interface [polypeptide binding]; other site 137722000675 putative CheW interface [polypeptide binding]; other site 137722000676 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 137722000677 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 137722000678 elongation factor G; Reviewed; Region: PRK12740 137722000679 G1 box; other site 137722000680 putative GEF interaction site [polypeptide binding]; other site 137722000681 GTP/Mg2+ binding site [chemical binding]; other site 137722000682 Switch I region; other site 137722000683 G2 box; other site 137722000684 G3 box; other site 137722000685 Switch II region; other site 137722000686 G4 box; other site 137722000687 G5 box; other site 137722000688 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 137722000689 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 137722000690 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 137722000691 PAS domain; Region: PAS_9; pfam13426 137722000692 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722000693 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722000694 dimer interface [polypeptide binding]; other site 137722000695 putative CheW interface [polypeptide binding]; other site 137722000696 argininosuccinate synthase; Provisional; Region: PRK13820 137722000697 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 137722000698 ANP binding site [chemical binding]; other site 137722000699 Substrate Binding Site II [chemical binding]; other site 137722000700 Substrate Binding Site I [chemical binding]; other site 137722000701 Bacterial SH3 domain; Region: SH3_4; pfam06347 137722000702 Bacterial SH3 domain; Region: SH3_4; pfam06347 137722000703 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 137722000704 Haemolysin-III related; Region: HlyIII; cl03831 137722000705 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 137722000706 MarR family; Region: MarR; pfam01047 137722000707 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 137722000708 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 137722000709 dimerization interface [polypeptide binding]; other site 137722000710 ligand binding site [chemical binding]; other site 137722000711 NADP binding site [chemical binding]; other site 137722000712 catalytic site [active] 137722000713 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722000714 active site 137722000715 DNA binding site [nucleotide binding] 137722000716 Int/Topo IB signature motif; other site 137722000717 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 137722000718 putative active site pocket [active] 137722000719 dimerization interface [polypeptide binding]; other site 137722000720 putative catalytic residue [active] 137722000721 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 137722000722 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 137722000723 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 137722000724 DNA methylase; Region: N6_N4_Mtase; pfam01555 137722000725 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 137722000726 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 137722000727 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 137722000728 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 137722000729 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 137722000730 Family description; Region: UvrD_C_2; pfam13538 137722000731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722000732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722000733 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 137722000734 putative effector binding pocket; other site 137722000735 dimerization interface [polypeptide binding]; other site 137722000736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722000737 putative transporter; Provisional; Region: PRK10504 137722000738 putative substrate translocation pore; other site 137722000739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722000740 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 137722000741 aspartate racemase; Region: asp_race; TIGR00035 137722000742 enoyl-CoA hydratase; Provisional; Region: PRK06127 137722000743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722000744 substrate binding site [chemical binding]; other site 137722000745 oxyanion hole (OAH) forming residues; other site 137722000746 trimer interface [polypeptide binding]; other site 137722000747 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 137722000748 putative RNA binding site [nucleotide binding]; other site 137722000749 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 137722000750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722000751 S-adenosylmethionine binding site [chemical binding]; other site 137722000752 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 137722000753 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 137722000754 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 137722000755 purine monophosphate binding site [chemical binding]; other site 137722000756 dimer interface [polypeptide binding]; other site 137722000757 putative catalytic residues [active] 137722000758 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 137722000759 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 137722000760 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 137722000761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722000762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722000763 DNA binding residues [nucleotide binding] 137722000764 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 137722000765 active site 137722000766 metal binding site [ion binding]; metal-binding site 137722000767 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 137722000768 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 137722000769 4Fe-4S binding domain; Region: Fer4; cl02805 137722000770 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 137722000771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722000772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722000773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722000774 dimerization interface [polypeptide binding]; other site 137722000775 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 137722000776 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 137722000777 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 137722000778 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 137722000779 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 137722000780 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722000781 FeS/SAM binding site; other site 137722000782 Uncharacterized conserved protein [Function unknown]; Region: COG4544 137722000783 DTW domain; Region: DTW; cl01221 137722000784 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 137722000785 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 137722000786 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 137722000787 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 137722000788 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 137722000789 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722000790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722000791 putative DNA binding site [nucleotide binding]; other site 137722000792 putative Zn2+ binding site [ion binding]; other site 137722000793 AsnC family; Region: AsnC_trans_reg; pfam01037 137722000794 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 137722000795 Chromate transporter; Region: Chromate_transp; pfam02417 137722000796 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 137722000797 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 137722000798 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 137722000799 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 137722000800 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 137722000801 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 137722000802 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 137722000803 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 137722000804 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 137722000805 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 137722000806 ATP-grasp domain; Region: ATP-grasp_4; cl17255 137722000807 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 137722000808 IMP binding site; other site 137722000809 dimer interface [polypeptide binding]; other site 137722000810 partial ornithine binding site; other site 137722000811 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 137722000812 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 137722000813 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 137722000814 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 137722000815 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 137722000816 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 137722000817 [4Fe-4S] binding site [ion binding]; other site 137722000818 molybdopterin cofactor binding site; other site 137722000819 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 137722000820 molybdopterin cofactor binding site; other site 137722000821 NapD protein; Region: NapD; pfam03927 137722000822 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 137722000823 MgtC family; Region: MgtC; pfam02308 137722000824 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 137722000825 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 137722000826 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 137722000827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722000828 dimer interface [polypeptide binding]; other site 137722000829 phosphorylation site [posttranslational modification] 137722000830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722000831 ATP binding site [chemical binding]; other site 137722000832 Mg2+ binding site [ion binding]; other site 137722000833 G-X-G motif; other site 137722000834 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 137722000835 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 137722000836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722000837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722000838 dimer interface [polypeptide binding]; other site 137722000839 phosphorylation site [posttranslational modification] 137722000840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722000841 ATP binding site [chemical binding]; other site 137722000842 Mg2+ binding site [ion binding]; other site 137722000843 G-X-G motif; other site 137722000844 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 137722000845 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 137722000846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722000847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722000848 dimer interface [polypeptide binding]; other site 137722000849 phosphorylation site [posttranslational modification] 137722000850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722000851 ATP binding site [chemical binding]; other site 137722000852 Mg2+ binding site [ion binding]; other site 137722000853 G-X-G motif; other site 137722000854 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 137722000855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 137722000856 DinB superfamily; Region: DinB_2; pfam12867 137722000857 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 137722000858 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 137722000859 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 137722000860 PAS fold; Region: PAS_4; pfam08448 137722000861 methionine sulfoxide reductase A; Provisional; Region: PRK00058 137722000862 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 137722000863 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 137722000864 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 137722000865 Predicted membrane protein [Function unknown]; Region: COG1238 137722000866 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 137722000867 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 137722000868 glucokinase, proteobacterial type; Region: glk; TIGR00749 137722000869 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 137722000870 nucleotide binding site [chemical binding]; other site 137722000871 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 137722000872 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 137722000873 active site 137722000874 homotetramer interface [polypeptide binding]; other site 137722000875 N-formylglutamate amidohydrolase; Region: FGase; cl01522 137722000876 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722000877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722000878 binding surface 137722000879 TPR motif; other site 137722000880 TPR repeat; Region: TPR_11; pfam13414 137722000881 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 137722000882 TIGR02300 family protein; Region: FYDLN_acid 137722000883 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 137722000884 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 137722000885 hinge; other site 137722000886 active site 137722000887 cytidylate kinase; Provisional; Region: cmk; PRK00023 137722000888 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 137722000889 CMP-binding site; other site 137722000890 The sites determining sugar specificity; other site 137722000891 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 137722000892 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 137722000893 RNA binding site [nucleotide binding]; other site 137722000894 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 137722000895 RNA binding site [nucleotide binding]; other site 137722000896 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 137722000897 RNA binding site [nucleotide binding]; other site 137722000898 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 137722000899 RNA binding site [nucleotide binding]; other site 137722000900 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 137722000901 RNA binding site [nucleotide binding]; other site 137722000902 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 137722000903 RNA binding site [nucleotide binding]; other site 137722000904 PRC-barrel domain; Region: PRC; pfam05239 137722000905 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 137722000906 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 137722000907 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 137722000908 Transcriptional regulator; Region: Transcrip_reg; cl00361 137722000909 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 137722000910 active site 137722000911 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 137722000912 TSCPD domain; Region: TSCPD; pfam12637 137722000913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722000914 PAS domain; Region: PAS_9; pfam13426 137722000915 putative active site [active] 137722000916 heme pocket [chemical binding]; other site 137722000917 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 137722000918 GAF domain; Region: GAF; pfam01590 137722000919 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722000920 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722000921 metal binding site [ion binding]; metal-binding site 137722000922 active site 137722000923 I-site; other site 137722000924 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722000925 pyruvate phosphate dikinase; Provisional; Region: PRK09279 137722000926 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 137722000927 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 137722000928 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 137722000929 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 137722000930 dimerization interface [polypeptide binding]; other site 137722000931 putative DNA binding site [nucleotide binding]; other site 137722000932 putative Zn2+ binding site [ion binding]; other site 137722000933 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722000934 putative DNA binding site [nucleotide binding]; other site 137722000935 putative Zn2+ binding site [ion binding]; other site 137722000936 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722000937 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 137722000938 dimerization interface [polypeptide binding]; other site 137722000939 substrate binding pocket [chemical binding]; other site 137722000940 glycogen synthase; Provisional; Region: glgA; PRK00654 137722000941 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 137722000942 ADP-binding pocket [chemical binding]; other site 137722000943 homodimer interface [polypeptide binding]; other site 137722000944 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 137722000945 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 137722000946 ligand binding site; other site 137722000947 oligomer interface; other site 137722000948 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 137722000949 dimer interface [polypeptide binding]; other site 137722000950 N-terminal domain interface [polypeptide binding]; other site 137722000951 sulfate 1 binding site; other site 137722000952 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 137722000953 Pirin-related protein [General function prediction only]; Region: COG1741 137722000954 Pirin; Region: Pirin; pfam02678 137722000955 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 137722000956 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722000957 putative active site [active] 137722000958 PAS fold; Region: PAS_3; pfam08447 137722000959 heme pocket [chemical binding]; other site 137722000960 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722000961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722000962 metal binding site [ion binding]; metal-binding site 137722000963 active site 137722000964 I-site; other site 137722000965 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722000966 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 137722000967 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 137722000968 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 137722000969 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 137722000970 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 137722000971 active site 137722000972 DNA binding site [nucleotide binding] 137722000973 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 137722000974 DNA binding site [nucleotide binding] 137722000975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722000976 motif II; other site 137722000977 LysE type translocator; Region: LysE; cl00565 137722000978 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 137722000979 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722000980 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722000981 dimerization interface [polypeptide binding]; other site 137722000982 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 137722000983 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 137722000984 nucleophile elbow; other site 137722000985 Patatin phospholipase; Region: DUF3734; pfam12536 137722000986 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 137722000987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722000988 NAD(P) binding site [chemical binding]; other site 137722000989 active site 137722000990 Hpt domain; Region: Hpt; pfam01627 137722000991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 137722000992 phosphorylation site [posttranslational modification] 137722000993 intermolecular recognition site; other site 137722000994 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 137722000995 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 137722000996 substrate-cofactor binding pocket; other site 137722000997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722000998 catalytic residue [active] 137722000999 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 137722001000 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 137722001001 active site 137722001002 diguanylate cyclase; Provisional; Region: PRK09894 137722001003 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 137722001004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722001005 metal binding site [ion binding]; metal-binding site 137722001006 active site 137722001007 I-site; other site 137722001008 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 137722001009 active site 137722001010 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 137722001011 active site 137722001012 dimer interface [polypeptide binding]; other site 137722001013 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 137722001014 heme binding pocket [chemical binding]; other site 137722001015 heme ligand [chemical binding]; other site 137722001016 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 137722001017 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 137722001018 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 137722001019 Walker A/P-loop; other site 137722001020 ATP binding site [chemical binding]; other site 137722001021 Q-loop/lid; other site 137722001022 ABC transporter signature motif; other site 137722001023 Walker B; other site 137722001024 D-loop; other site 137722001025 H-loop/switch region; other site 137722001026 HAMP domain; Region: HAMP; pfam00672 137722001027 dimerization interface [polypeptide binding]; other site 137722001028 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722001029 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722001030 dimer interface [polypeptide binding]; other site 137722001031 putative CheW interface [polypeptide binding]; other site 137722001032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722001033 putative PBP binding loops; other site 137722001034 dimer interface [polypeptide binding]; other site 137722001035 ABC-ATPase subunit interface; other site 137722001036 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722001037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722001038 dimer interface [polypeptide binding]; other site 137722001039 conserved gate region; other site 137722001040 putative PBP binding loops; other site 137722001041 ABC-ATPase subunit interface; other site 137722001042 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 137722001043 active site 137722001044 TRAM domain; Region: TRAM; cl01282 137722001045 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 137722001046 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 137722001047 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 137722001048 putative RNA binding site [nucleotide binding]; other site 137722001049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722001050 S-adenosylmethionine binding site [chemical binding]; other site 137722001051 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 137722001052 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 137722001053 Low-spin heme binding site [chemical binding]; other site 137722001054 Putative water exit pathway; other site 137722001055 Binuclear center (active site) [active] 137722001056 Putative proton exit pathway; other site 137722001057 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 137722001058 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 137722001059 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 137722001060 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 137722001061 Cytochrome c; Region: Cytochrom_C; cl11414 137722001062 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 137722001063 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 137722001064 FixH; Region: FixH; pfam05751 137722001065 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 137722001066 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 137722001067 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 137722001068 metal-binding site [ion binding] 137722001069 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 137722001070 Soluble P-type ATPase [General function prediction only]; Region: COG4087 137722001071 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 137722001072 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722001073 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722001074 ligand binding site [chemical binding]; other site 137722001075 flexible hinge region; other site 137722001076 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 137722001077 putative switch regulator; other site 137722001078 non-specific DNA interactions [nucleotide binding]; other site 137722001079 DNA binding site [nucleotide binding] 137722001080 sequence specific DNA binding site [nucleotide binding]; other site 137722001081 putative cAMP binding site [chemical binding]; other site 137722001082 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 137722001083 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 137722001084 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 137722001085 catalytic residues [active] 137722001086 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 137722001087 oligomerisation interface [polypeptide binding]; other site 137722001088 mobile loop; other site 137722001089 roof hairpin; other site 137722001090 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 137722001091 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 137722001092 ring oligomerisation interface [polypeptide binding]; other site 137722001093 ATP/Mg binding site [chemical binding]; other site 137722001094 stacking interactions; other site 137722001095 hinge regions; other site 137722001096 EamA-like transporter family; Region: EamA; pfam00892 137722001097 EamA-like transporter family; Region: EamA; pfam00892 137722001098 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 137722001099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722001100 active site 137722001101 phosphorylation site [posttranslational modification] 137722001102 intermolecular recognition site; other site 137722001103 dimerization interface [polypeptide binding]; other site 137722001104 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722001105 DNA binding residues [nucleotide binding] 137722001106 dimerization interface [polypeptide binding]; other site 137722001107 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 137722001108 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 137722001109 putative NAD(P) binding site [chemical binding]; other site 137722001110 dimer interface [polypeptide binding]; other site 137722001111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722001112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722001113 dimerization interface [polypeptide binding]; other site 137722001114 PBP superfamily domain; Region: PBP_like_2; pfam12849 137722001115 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 137722001116 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 137722001117 HerA helicase [Replication, recombination, and repair]; Region: COG0433 137722001118 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722001119 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 137722001120 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722001121 metal binding site [ion binding]; metal-binding site 137722001122 active site 137722001123 I-site; other site 137722001124 Protein of unknown function (DUF497); Region: DUF497; pfam04365 137722001125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722001126 non-specific DNA binding site [nucleotide binding]; other site 137722001127 salt bridge; other site 137722001128 sequence-specific DNA binding site [nucleotide binding]; other site 137722001129 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 137722001130 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722001131 Walker A/P-loop; other site 137722001132 ATP binding site [chemical binding]; other site 137722001133 Q-loop/lid; other site 137722001134 ABC transporter signature motif; other site 137722001135 Walker B; other site 137722001136 D-loop; other site 137722001137 H-loop/switch region; other site 137722001138 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 137722001139 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722001140 Walker A/P-loop; other site 137722001141 ATP binding site [chemical binding]; other site 137722001142 Q-loop/lid; other site 137722001143 ABC transporter signature motif; other site 137722001144 Walker B; other site 137722001145 D-loop; other site 137722001146 H-loop/switch region; other site 137722001147 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722001148 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 137722001149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722001150 dimer interface [polypeptide binding]; other site 137722001151 conserved gate region; other site 137722001152 ABC-ATPase subunit interface; other site 137722001153 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 137722001154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722001155 dimer interface [polypeptide binding]; other site 137722001156 conserved gate region; other site 137722001157 putative PBP binding loops; other site 137722001158 ABC-ATPase subunit interface; other site 137722001159 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 137722001160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 137722001161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 137722001162 Predicted transcriptional regulators [Transcription]; Region: COG1695 137722001163 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 137722001164 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 137722001165 Rrf2 family protein; Region: rrf2_super; TIGR00738 137722001166 Transcriptional regulator; Region: Rrf2; pfam02082 137722001167 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 137722001168 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 137722001169 dimer interface [polypeptide binding]; other site 137722001170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722001171 catalytic residue [active] 137722001172 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 137722001173 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 137722001174 ATP binding site [chemical binding]; other site 137722001175 substrate interface [chemical binding]; other site 137722001176 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 137722001177 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 137722001178 Uncharacterized conserved protein [Function unknown]; Region: COG2128 137722001179 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 137722001180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722001181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722001182 DNA binding residues [nucleotide binding] 137722001183 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 137722001184 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 137722001185 metal binding site 2 [ion binding]; metal-binding site 137722001186 putative DNA binding helix; other site 137722001187 metal binding site 1 [ion binding]; metal-binding site 137722001188 dimer interface [polypeptide binding]; other site 137722001189 structural Zn2+ binding site [ion binding]; other site 137722001190 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 137722001191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722001192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722001193 dimer interface [polypeptide binding]; other site 137722001194 phosphorylation site [posttranslational modification] 137722001195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722001196 ATP binding site [chemical binding]; other site 137722001197 Mg2+ binding site [ion binding]; other site 137722001198 G-X-G motif; other site 137722001199 heat shock protein 90; Provisional; Region: PRK05218 137722001200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722001201 ATP binding site [chemical binding]; other site 137722001202 Mg2+ binding site [ion binding]; other site 137722001203 G-X-G motif; other site 137722001204 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 137722001205 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 137722001206 C-terminal domain interface [polypeptide binding]; other site 137722001207 GSH binding site (G-site) [chemical binding]; other site 137722001208 dimer interface [polypeptide binding]; other site 137722001209 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 137722001210 dimer interface [polypeptide binding]; other site 137722001211 N-terminal domain interface [polypeptide binding]; other site 137722001212 substrate binding pocket (H-site) [chemical binding]; other site 137722001213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722001214 Coenzyme A binding pocket [chemical binding]; other site 137722001215 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 137722001216 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 137722001217 HupE / UreJ protein; Region: HupE_UreJ; cl01011 137722001218 DNA Polymerase Y-family; Region: PolY_like; cd03468 137722001219 active site 137722001220 DNA binding site [nucleotide binding] 137722001221 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 137722001222 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 137722001223 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 137722001224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722001225 S-adenosylmethionine binding site [chemical binding]; other site 137722001226 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 137722001227 malate synthase A; Region: malate_syn_A; TIGR01344 137722001228 active site 137722001229 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 137722001230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722001231 Walker A motif; other site 137722001232 ATP binding site [chemical binding]; other site 137722001233 Walker B motif; other site 137722001234 arginine finger; other site 137722001235 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722001236 phage shock protein A; Region: phageshock_pspA; TIGR02977 137722001237 Phage shock protein B; Region: PspB; pfam06667 137722001238 phage shock protein C; Region: phageshock_pspC; TIGR02978 137722001239 PspC domain; Region: PspC; pfam04024 137722001240 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 137722001241 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 137722001242 MAPEG family; Region: MAPEG; pfam01124 137722001243 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 137722001244 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 137722001245 active site 137722001246 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 137722001247 Right handed beta helix region; Region: Beta_helix; pfam13229 137722001248 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 137722001249 HemY protein N-terminus; Region: HemY_N; pfam07219 137722001250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 137722001251 TPR motif; other site 137722001252 binding surface 137722001253 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 137722001254 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 137722001255 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 137722001256 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 137722001257 active site 137722001258 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 137722001259 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 137722001260 domain interfaces; other site 137722001261 active site 137722001262 UGMP family protein; Validated; Region: PRK09604 137722001263 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 137722001264 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 137722001265 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 137722001266 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 137722001267 Predicted transcriptional regulator [Transcription]; Region: COG2378 137722001268 HTH domain; Region: HTH_11; pfam08279 137722001269 WYL domain; Region: WYL; pfam13280 137722001270 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 137722001271 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 137722001272 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 137722001273 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 137722001274 putative active site [active] 137722001275 putative PHP Thumb interface [polypeptide binding]; other site 137722001276 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 137722001277 generic binding surface II; other site 137722001278 generic binding surface I; other site 137722001279 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722001280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722001281 active site 137722001282 phosphorylation site [posttranslational modification] 137722001283 intermolecular recognition site; other site 137722001284 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722001285 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722001286 metal binding site [ion binding]; metal-binding site 137722001287 active site 137722001288 I-site; other site 137722001289 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 137722001290 potassium uptake protein; Region: kup; TIGR00794 137722001291 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 137722001292 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 137722001293 dimerization interface [polypeptide binding]; other site 137722001294 domain crossover interface; other site 137722001295 redox-dependent activation switch; other site 137722001296 ornithine carbamoyltransferase; Provisional; Region: PRK00779 137722001297 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 137722001298 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 137722001299 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 137722001300 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 137722001301 inhibitor-cofactor binding pocket; inhibition site 137722001302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722001303 catalytic residue [active] 137722001304 ABC-2 type transporter; Region: ABC2_membrane; cl17235 137722001305 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 137722001306 RecX family; Region: RecX; pfam02631 137722001307 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 137722001308 membrane ATPase/protein kinase; Provisional; Region: PRK09435 137722001309 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 137722001310 Walker A; other site 137722001311 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 137722001312 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722001313 Walker A/P-loop; other site 137722001314 ATP binding site [chemical binding]; other site 137722001315 Q-loop/lid; other site 137722001316 ABC transporter signature motif; other site 137722001317 Walker B; other site 137722001318 D-loop; other site 137722001319 H-loop/switch region; other site 137722001320 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 137722001321 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722001322 Walker A/P-loop; other site 137722001323 ATP binding site [chemical binding]; other site 137722001324 Q-loop/lid; other site 137722001325 ABC transporter signature motif; other site 137722001326 Walker B; other site 137722001327 D-loop; other site 137722001328 H-loop/switch region; other site 137722001329 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 137722001330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722001331 dimer interface [polypeptide binding]; other site 137722001332 conserved gate region; other site 137722001333 ABC-ATPase subunit interface; other site 137722001334 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 137722001335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722001336 dimer interface [polypeptide binding]; other site 137722001337 conserved gate region; other site 137722001338 putative PBP binding loops; other site 137722001339 ABC-ATPase subunit interface; other site 137722001340 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 137722001341 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 137722001342 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 137722001343 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 137722001344 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 137722001345 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 137722001346 active site 137722001347 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 137722001348 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 137722001349 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 137722001350 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 137722001351 putative NADH binding site [chemical binding]; other site 137722001352 putative active site [active] 137722001353 nudix motif; other site 137722001354 putative metal binding site [ion binding]; other site 137722001355 prephenate dehydratase; Provisional; Region: PRK11899 137722001356 Prephenate dehydratase; Region: PDT; pfam00800 137722001357 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 137722001358 putative L-Phe binding site [chemical binding]; other site 137722001359 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 137722001360 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 137722001361 Ligand binding site; other site 137722001362 oligomer interface; other site 137722001363 Cytochrome c2 [Energy production and conversion]; Region: COG3474 137722001364 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 137722001365 nudix motif; other site 137722001366 Response regulator receiver domain; Region: Response_reg; pfam00072 137722001367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722001368 active site 137722001369 phosphorylation site [posttranslational modification] 137722001370 intermolecular recognition site; other site 137722001371 dimerization interface [polypeptide binding]; other site 137722001372 PrkA family serine protein kinase; Provisional; Region: PRK15455 137722001373 AAA ATPase domain; Region: AAA_16; pfam13191 137722001374 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 137722001375 hypothetical protein; Provisional; Region: PRK05325 137722001376 SpoVR family protein; Provisional; Region: PRK11767 137722001377 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 137722001378 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 137722001379 ubiquinone biosynthesis monooxygenase COQ6; Region: COQ6; TIGR01989 137722001380 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 137722001381 Beta-lactamase; Region: Beta-lactamase; pfam00144 137722001382 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 137722001383 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 137722001384 acyl-activating enzyme (AAE) consensus motif; other site 137722001385 putative AMP binding site [chemical binding]; other site 137722001386 putative active site [active] 137722001387 putative CoA binding site [chemical binding]; other site 137722001388 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 137722001389 lipoate-protein ligase B; Provisional; Region: PRK14341 137722001390 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 137722001391 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 137722001392 anti sigma factor interaction site; other site 137722001393 regulatory phosphorylation site [posttranslational modification]; other site 137722001394 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 137722001395 MgtE intracellular N domain; Region: MgtE_N; smart00924 137722001396 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 137722001397 Divalent cation transporter; Region: MgtE; pfam01769 137722001398 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 137722001399 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 137722001400 thiS-thiF/thiG interaction site; other site 137722001401 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 137722001402 ThiS interaction site; other site 137722001403 putative active site [active] 137722001404 tetramer interface [polypeptide binding]; other site 137722001405 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 137722001406 CoenzymeA binding site [chemical binding]; other site 137722001407 subunit interaction site [polypeptide binding]; other site 137722001408 PHB binding site; other site 137722001409 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 137722001410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722001411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722001412 active site 137722001413 phosphorylation site [posttranslational modification] 137722001414 intermolecular recognition site; other site 137722001415 dimerization interface [polypeptide binding]; other site 137722001416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722001417 DNA binding site [nucleotide binding] 137722001418 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 137722001419 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 137722001420 putative catalytic residue [active] 137722001421 Ion channel; Region: Ion_trans_2; pfam07885 137722001422 Protein of unknown function (DUF1489); Region: DUF1489; cl11570 137722001423 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722001424 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722001425 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722001426 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722001427 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722001428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722001429 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722001430 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722001431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722001432 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722001433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722001434 Transposase; Region: HTH_Tnp_1; pfam01527 137722001435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 137722001436 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722001437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722001438 Walker A motif; other site 137722001439 ATP binding site [chemical binding]; other site 137722001440 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722001441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722001442 Integrase core domain; Region: rve; pfam00665 137722001443 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722001444 AAA domain; Region: AAA_27; pfam13514 137722001445 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 137722001446 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 137722001447 active site 137722001448 metal binding site [ion binding]; metal-binding site 137722001449 DNA binding site [nucleotide binding] 137722001450 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 137722001451 Part of AAA domain; Region: AAA_19; pfam13245 137722001452 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 137722001453 AAA domain; Region: AAA_12; pfam13087 137722001454 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 137722001455 putative active site [active] 137722001456 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 137722001457 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 137722001458 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 137722001459 metal binding site [ion binding]; metal-binding site 137722001460 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 137722001461 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 137722001462 ABC-ATPase subunit interface; other site 137722001463 dimer interface [polypeptide binding]; other site 137722001464 putative PBP binding regions; other site 137722001465 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 137722001466 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 137722001467 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 137722001468 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 137722001469 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 137722001470 N-terminal plug; other site 137722001471 ligand-binding site [chemical binding]; other site 137722001472 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 137722001473 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 137722001474 dimer interface [polypeptide binding]; other site 137722001475 putative PBP binding regions; other site 137722001476 ABC-ATPase subunit interface; other site 137722001477 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 137722001478 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 137722001479 putative ligand binding residues [chemical binding]; other site 137722001480 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 137722001481 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 137722001482 Walker A/P-loop; other site 137722001483 ATP binding site [chemical binding]; other site 137722001484 Q-loop/lid; other site 137722001485 ABC transporter signature motif; other site 137722001486 Walker B; other site 137722001487 D-loop; other site 137722001488 H-loop/switch region; other site 137722001489 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 137722001490 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 137722001491 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 137722001492 active site 137722001493 HIGH motif; other site 137722001494 dimer interface [polypeptide binding]; other site 137722001495 KMSKS motif; other site 137722001496 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 137722001497 RNA binding surface [nucleotide binding]; other site 137722001498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 137722001499 Peptidase M15; Region: Peptidase_M15_3; cl01194 137722001500 DNA repair protein radc; Region: radc; TIGR00608 137722001501 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 137722001502 MPN+ (JAMM) motif; other site 137722001503 Zinc-binding site [ion binding]; other site 137722001504 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 137722001505 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 137722001506 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722001507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722001508 dimer interface [polypeptide binding]; other site 137722001509 phosphorylation site [posttranslational modification] 137722001510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722001511 ATP binding site [chemical binding]; other site 137722001512 Mg2+ binding site [ion binding]; other site 137722001513 G-X-G motif; other site 137722001514 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722001515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722001516 active site 137722001517 phosphorylation site [posttranslational modification] 137722001518 intermolecular recognition site; other site 137722001519 dimerization interface [polypeptide binding]; other site 137722001520 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722001521 DNA binding site [nucleotide binding] 137722001522 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 137722001523 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 137722001524 ligand binding site [chemical binding]; other site 137722001525 NAD binding site [chemical binding]; other site 137722001526 dimerization interface [polypeptide binding]; other site 137722001527 catalytic site [active] 137722001528 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 137722001529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 137722001530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 137722001531 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 137722001532 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 137722001533 FAD binding domain; Region: FAD_binding_4; pfam01565 137722001534 FAD binding domain; Region: FAD_binding_4; pfam01565 137722001535 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 137722001536 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 137722001537 Cysteine-rich domain; Region: CCG; pfam02754 137722001538 Cysteine-rich domain; Region: CCG; pfam02754 137722001539 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 137722001540 Protein of unknown function DUF72; Region: DUF72; pfam01904 137722001541 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 137722001542 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 137722001543 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 137722001544 active site 137722001545 NAD binding site [chemical binding]; other site 137722001546 metal binding site [ion binding]; metal-binding site 137722001547 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 137722001548 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722001549 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722001550 active site 137722001551 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 137722001552 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722001553 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722001554 catalytic residue [active] 137722001555 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 137722001556 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 137722001557 putative dimer interface [polypeptide binding]; other site 137722001558 active site pocket [active] 137722001559 putative cataytic base [active] 137722001560 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 137722001561 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 137722001562 metal binding site [ion binding]; metal-binding site 137722001563 dimer interface [polypeptide binding]; other site 137722001564 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 137722001565 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 137722001566 trimer interface [polypeptide binding]; other site 137722001567 active site 137722001568 substrate binding site [chemical binding]; other site 137722001569 CoA binding site [chemical binding]; other site 137722001570 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 137722001571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722001572 motif II; other site 137722001573 PAS domain; Region: PAS_9; pfam13426 137722001574 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722001575 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722001576 metal binding site [ion binding]; metal-binding site 137722001577 active site 137722001578 I-site; other site 137722001579 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 137722001580 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 137722001581 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722001582 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722001583 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 137722001584 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722001585 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722001586 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722001587 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722001588 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722001589 signal recognition particle protein; Provisional; Region: PRK10867 137722001590 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 137722001591 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 137722001592 P loop; other site 137722001593 GTP binding site [chemical binding]; other site 137722001594 Signal peptide binding domain; Region: SRP_SPB; pfam02978 137722001595 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 137722001596 RimM N-terminal domain; Region: RimM; pfam01782 137722001597 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 137722001598 PRC-barrel domain; Region: PRC; pfam05239 137722001599 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 137722001600 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 137722001601 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 137722001602 Ribonuclease P; Region: Ribonuclease_P; pfam00825 137722001603 Haemolytic domain; Region: Haemolytic; pfam01809 137722001604 membrane protein insertase; Provisional; Region: PRK01318 137722001605 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 137722001606 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 137722001607 G1 box; other site 137722001608 GTP/Mg2+ binding site [chemical binding]; other site 137722001609 Switch I region; other site 137722001610 G2 box; other site 137722001611 G3 box; other site 137722001612 Switch II region; other site 137722001613 G4 box; other site 137722001614 G5 box; other site 137722001615 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 137722001616 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 137722001617 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 137722001618 feedback inhibition sensing region; other site 137722001619 homohexameric interface [polypeptide binding]; other site 137722001620 nucleotide binding site [chemical binding]; other site 137722001621 N-acetyl-L-glutamate binding site [chemical binding]; other site 137722001622 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 137722001623 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 137722001624 Cl binding site [ion binding]; other site 137722001625 oligomer interface [polypeptide binding]; other site 137722001626 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 137722001627 ThiC-associated domain; Region: ThiC-associated; pfam13667 137722001628 ThiC family; Region: ThiC; pfam01964 137722001629 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 137722001630 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 137722001631 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 137722001632 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 137722001633 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 137722001634 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 137722001635 AMIN domain; Region: AMIN; pfam11741 137722001636 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 137722001637 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 137722001638 active site 137722001639 metal binding site [ion binding]; metal-binding site 137722001640 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 137722001641 Transglycosylase; Region: Transgly; pfam00912 137722001642 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 137722001643 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 137722001644 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722001645 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722001646 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 137722001647 peptide chain release factor 2; Provisional; Region: PRK07342 137722001648 This domain is found in peptide chain release factors; Region: PCRF; smart00937 137722001649 RF-1 domain; Region: RF-1; pfam00472 137722001650 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 137722001651 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 137722001652 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 137722001653 fructokinase; Reviewed; Region: PRK09557 137722001654 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 137722001655 nucleotide binding site [chemical binding]; other site 137722001656 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 137722001657 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 137722001658 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 137722001659 Caspase domain; Region: Peptidase_C14; pfam00656 137722001660 MORN repeat; Region: MORN; pfam02493 137722001661 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 137722001662 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722001663 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722001664 Walker A/P-loop; other site 137722001665 ATP binding site [chemical binding]; other site 137722001666 Q-loop/lid; other site 137722001667 ABC transporter signature motif; other site 137722001668 Walker B; other site 137722001669 D-loop; other site 137722001670 H-loop/switch region; other site 137722001671 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722001672 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 137722001673 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722001674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722001675 dimer interface [polypeptide binding]; other site 137722001676 conserved gate region; other site 137722001677 putative PBP binding loops; other site 137722001678 ABC-ATPase subunit interface; other site 137722001679 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722001680 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722001681 Walker A/P-loop; other site 137722001682 ATP binding site [chemical binding]; other site 137722001683 Q-loop/lid; other site 137722001684 ABC transporter signature motif; other site 137722001685 Walker B; other site 137722001686 D-loop; other site 137722001687 H-loop/switch region; other site 137722001688 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722001689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722001690 dimer interface [polypeptide binding]; other site 137722001691 conserved gate region; other site 137722001692 ABC-ATPase subunit interface; other site 137722001693 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 137722001694 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722001695 substrate binding pocket [chemical binding]; other site 137722001696 membrane-bound complex binding site; other site 137722001697 hinge residues; other site 137722001698 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722001699 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722001700 Walker A/P-loop; other site 137722001701 ATP binding site [chemical binding]; other site 137722001702 Q-loop/lid; other site 137722001703 ABC transporter signature motif; other site 137722001704 Walker B; other site 137722001705 D-loop; other site 137722001706 H-loop/switch region; other site 137722001707 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722001708 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722001709 Walker A/P-loop; other site 137722001710 ATP binding site [chemical binding]; other site 137722001711 Q-loop/lid; other site 137722001712 ABC transporter signature motif; other site 137722001713 Walker B; other site 137722001714 D-loop; other site 137722001715 H-loop/switch region; other site 137722001716 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722001717 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722001718 TM-ABC transporter signature motif; other site 137722001719 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722001720 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722001721 TM-ABC transporter signature motif; other site 137722001722 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 137722001723 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 137722001724 putative ligand binding site [chemical binding]; other site 137722001725 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722001726 MarR family; Region: MarR; pfam01047 137722001727 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 137722001728 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 137722001729 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 137722001730 SLBB domain; Region: SLBB; pfam10531 137722001731 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 137722001732 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 137722001733 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 137722001734 elongation factor Tu; Reviewed; Region: PRK00049 137722001735 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 137722001736 G1 box; other site 137722001737 GEF interaction site [polypeptide binding]; other site 137722001738 GTP/Mg2+ binding site [chemical binding]; other site 137722001739 Switch I region; other site 137722001740 G2 box; other site 137722001741 G3 box; other site 137722001742 Switch II region; other site 137722001743 G4 box; other site 137722001744 G5 box; other site 137722001745 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 137722001746 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 137722001747 Antibiotic Binding Site [chemical binding]; other site 137722001748 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 137722001749 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 137722001750 putative homodimer interface [polypeptide binding]; other site 137722001751 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 137722001752 heterodimer interface [polypeptide binding]; other site 137722001753 homodimer interface [polypeptide binding]; other site 137722001754 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 137722001755 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 137722001756 23S rRNA interface [nucleotide binding]; other site 137722001757 L7/L12 interface [polypeptide binding]; other site 137722001758 putative thiostrepton binding site; other site 137722001759 L25 interface [polypeptide binding]; other site 137722001760 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 137722001761 mRNA/rRNA interface [nucleotide binding]; other site 137722001762 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 137722001763 23S rRNA interface [nucleotide binding]; other site 137722001764 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 137722001765 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 137722001766 L11 interface [polypeptide binding]; other site 137722001767 putative EF-Tu interaction site [polypeptide binding]; other site 137722001768 putative EF-G interaction site [polypeptide binding]; other site 137722001769 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 137722001770 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 137722001771 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 137722001772 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 137722001773 RPB11 interaction site [polypeptide binding]; other site 137722001774 RPB12 interaction site [polypeptide binding]; other site 137722001775 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 137722001776 RPB1 interaction site [polypeptide binding]; other site 137722001777 RPB11 interaction site [polypeptide binding]; other site 137722001778 RPB10 interaction site [polypeptide binding]; other site 137722001779 RPB3 interaction site [polypeptide binding]; other site 137722001780 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 137722001781 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 137722001782 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 137722001783 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 137722001784 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 137722001785 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 137722001786 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 137722001787 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 137722001788 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 137722001789 DNA binding site [nucleotide binding] 137722001790 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 137722001791 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 137722001792 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 137722001793 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 137722001794 conserved cys residue [active] 137722001795 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 137722001796 S17 interaction site [polypeptide binding]; other site 137722001797 S8 interaction site; other site 137722001798 16S rRNA interaction site [nucleotide binding]; other site 137722001799 streptomycin interaction site [chemical binding]; other site 137722001800 23S rRNA interaction site [nucleotide binding]; other site 137722001801 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 137722001802 30S ribosomal protein S7; Validated; Region: PRK05302 137722001803 elongation factor G; Reviewed; Region: PRK00007 137722001804 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 137722001805 G1 box; other site 137722001806 putative GEF interaction site [polypeptide binding]; other site 137722001807 GTP/Mg2+ binding site [chemical binding]; other site 137722001808 Switch I region; other site 137722001809 G2 box; other site 137722001810 G3 box; other site 137722001811 Switch II region; other site 137722001812 G4 box; other site 137722001813 G5 box; other site 137722001814 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 137722001815 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 137722001816 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 137722001817 elongation factor Tu; Reviewed; Region: PRK00049 137722001818 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 137722001819 G1 box; other site 137722001820 GEF interaction site [polypeptide binding]; other site 137722001821 GTP/Mg2+ binding site [chemical binding]; other site 137722001822 Switch I region; other site 137722001823 G2 box; other site 137722001824 G3 box; other site 137722001825 Switch II region; other site 137722001826 G4 box; other site 137722001827 G5 box; other site 137722001828 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 137722001829 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 137722001830 Antibiotic Binding Site [chemical binding]; other site 137722001831 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 137722001832 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 137722001833 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 137722001834 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 137722001835 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 137722001836 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 137722001837 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 137722001838 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 137722001839 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 137722001840 putative translocon binding site; other site 137722001841 protein-rRNA interface [nucleotide binding]; other site 137722001842 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 137722001843 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 137722001844 G-X-X-G motif; other site 137722001845 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 137722001846 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 137722001847 23S rRNA interface [nucleotide binding]; other site 137722001848 5S rRNA interface [nucleotide binding]; other site 137722001849 putative antibiotic binding site [chemical binding]; other site 137722001850 L25 interface [polypeptide binding]; other site 137722001851 L27 interface [polypeptide binding]; other site 137722001852 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 137722001853 putative translocon interaction site; other site 137722001854 23S rRNA interface [nucleotide binding]; other site 137722001855 signal recognition particle (SRP54) interaction site; other site 137722001856 L23 interface [polypeptide binding]; other site 137722001857 trigger factor interaction site; other site 137722001858 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 137722001859 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 137722001860 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 137722001861 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 137722001862 RNA binding site [nucleotide binding]; other site 137722001863 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 137722001864 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 137722001865 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 137722001866 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 137722001867 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 137722001868 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 137722001869 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 137722001870 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 137722001871 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 137722001872 5S rRNA interface [nucleotide binding]; other site 137722001873 23S rRNA interface [nucleotide binding]; other site 137722001874 L5 interface [polypeptide binding]; other site 137722001875 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 137722001876 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 137722001877 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 137722001878 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 137722001879 23S rRNA binding site [nucleotide binding]; other site 137722001880 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 137722001881 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 137722001882 SecY translocase; Region: SecY; pfam00344 137722001883 adenylate kinase; Reviewed; Region: adk; PRK00279 137722001884 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 137722001885 AMP-binding site [chemical binding]; other site 137722001886 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 137722001887 Transcriptional regulators [Transcription]; Region: FadR; COG2186 137722001888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722001889 DNA-binding site [nucleotide binding]; DNA binding site 137722001890 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 137722001891 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 137722001892 EamA-like transporter family; Region: EamA; pfam00892 137722001893 Agenet domain; Region: Agenet; pfam05641 137722001894 N-formylglutamate amidohydrolase; Region: FGase; cl01522 137722001895 carboxylate-amine ligase; Provisional; Region: PRK13515 137722001896 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 137722001897 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722001898 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 137722001899 Walker A/P-loop; other site 137722001900 ATP binding site [chemical binding]; other site 137722001901 Q-loop/lid; other site 137722001902 ABC transporter signature motif; other site 137722001903 Walker B; other site 137722001904 D-loop; other site 137722001905 H-loop/switch region; other site 137722001906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 137722001907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 137722001908 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 137722001909 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 137722001910 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 137722001911 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 137722001912 homodimer interface [polypeptide binding]; other site 137722001913 substrate-cofactor binding pocket; other site 137722001914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722001915 catalytic residue [active] 137722001916 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 137722001917 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 137722001918 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 137722001919 PAS domain S-box; Region: sensory_box; TIGR00229 137722001920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722001921 putative active site [active] 137722001922 heme pocket [chemical binding]; other site 137722001923 PAS domain; Region: PAS; smart00091 137722001924 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722001925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722001926 dimer interface [polypeptide binding]; other site 137722001927 phosphorylation site [posttranslational modification] 137722001928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722001929 ATP binding site [chemical binding]; other site 137722001930 Mg2+ binding site [ion binding]; other site 137722001931 G-X-G motif; other site 137722001932 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 137722001933 Ligand Binding Site [chemical binding]; other site 137722001934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 137722001935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 137722001936 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 137722001937 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 137722001938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722001939 motif II; other site 137722001940 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 137722001941 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 137722001942 dimer interface [polypeptide binding]; other site 137722001943 active site 137722001944 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 137722001945 catalytic residues [active] 137722001946 substrate binding site [chemical binding]; other site 137722001947 MgtC family; Region: MgtC; pfam02308 137722001948 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 137722001949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722001950 putative substrate translocation pore; other site 137722001951 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 137722001952 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 137722001953 active site 137722001954 Riboflavin kinase; Region: Flavokinase; smart00904 137722001955 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 137722001956 dimer interaction site [polypeptide binding]; other site 137722001957 substrate-binding tunnel; other site 137722001958 active site 137722001959 catalytic site [active] 137722001960 substrate binding site [chemical binding]; other site 137722001961 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 137722001962 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 137722001963 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 137722001964 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 137722001965 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 137722001966 Domain of unknown function DUF20; Region: UPF0118; pfam01594 137722001967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 137722001968 CreA protein; Region: CreA; pfam05981 137722001969 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 137722001970 putative active site [active] 137722001971 Zn binding site [ion binding]; other site 137722001972 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 137722001973 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 137722001974 NRDE protein; Region: NRDE; cl01315 137722001975 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 137722001976 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 137722001977 ATP binding site [chemical binding]; other site 137722001978 active site 137722001979 substrate binding site [chemical binding]; other site 137722001980 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 137722001981 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 137722001982 endonuclease III; Region: ENDO3c; smart00478 137722001983 minor groove reading motif; other site 137722001984 helix-hairpin-helix signature motif; other site 137722001985 substrate binding pocket [chemical binding]; other site 137722001986 active site 137722001987 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 137722001988 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 137722001989 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 137722001990 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 137722001991 putative active site [active] 137722001992 putative metal binding site [ion binding]; other site 137722001993 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722001994 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 137722001995 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 137722001996 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 137722001997 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 137722001998 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 137722001999 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 137722002000 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 137722002001 putative acyl-acceptor binding pocket; other site 137722002002 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 137722002003 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 137722002004 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722002005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 137722002006 active site 137722002007 phosphorylation site [posttranslational modification] 137722002008 intermolecular recognition site; other site 137722002009 dimerization interface [polypeptide binding]; other site 137722002010 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 137722002011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722002012 dimer interface [polypeptide binding]; other site 137722002013 phosphorylation site [posttranslational modification] 137722002014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722002015 ATP binding site [chemical binding]; other site 137722002016 Mg2+ binding site [ion binding]; other site 137722002017 G-X-G motif; other site 137722002018 Response regulator receiver domain; Region: Response_reg; pfam00072 137722002019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722002020 active site 137722002021 phosphorylation site [posttranslational modification] 137722002022 intermolecular recognition site; other site 137722002023 dimerization interface [polypeptide binding]; other site 137722002024 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 137722002025 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 137722002026 Ligand binding site [chemical binding]; other site 137722002027 Electron transfer flavoprotein domain; Region: ETF; pfam01012 137722002028 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 137722002029 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 137722002030 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 137722002031 oxidoreductase; Provisional; Region: PRK10015 137722002032 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 137722002033 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 137722002034 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722002035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722002036 active site 137722002037 phosphorylation site [posttranslational modification] 137722002038 intermolecular recognition site; other site 137722002039 dimerization interface [polypeptide binding]; other site 137722002040 Nitrogen fixation protein NifW; Region: NifW; pfam03206 137722002041 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 137722002042 serine O-acetyltransferase; Region: cysE; TIGR01172 137722002043 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 137722002044 trimer interface [polypeptide binding]; other site 137722002045 active site 137722002046 substrate binding site [chemical binding]; other site 137722002047 CoA binding site [chemical binding]; other site 137722002048 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 137722002049 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 137722002050 active site 137722002051 catalytic residues [active] 137722002052 metal binding site [ion binding]; metal-binding site 137722002053 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 137722002054 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 137722002055 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722002056 catalytic residue [active] 137722002057 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 137722002058 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 137722002059 trimerization site [polypeptide binding]; other site 137722002060 active site 137722002061 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 137722002062 NifU-like domain; Region: NifU; pfam01106 137722002063 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 137722002064 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 137722002065 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 137722002066 FMN binding site [chemical binding]; other site 137722002067 active site 137722002068 substrate binding site [chemical binding]; other site 137722002069 catalytic residue [active] 137722002070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722002071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722002072 Predicted permeases [General function prediction only]; Region: RarD; COG2962 137722002073 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 137722002074 putative GSH binding site [chemical binding]; other site 137722002075 catalytic residues [active] 137722002076 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 137722002077 adenylosuccinate lyase; Provisional; Region: PRK07492 137722002078 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 137722002079 tetramer interface [polypeptide binding]; other site 137722002080 active site 137722002081 Cache domain; Region: Cache_2; cl07034 137722002082 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 137722002083 PAS domain S-box; Region: sensory_box; TIGR00229 137722002084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722002085 PAS domain; Region: PAS_9; pfam13426 137722002086 putative active site [active] 137722002087 heme pocket [chemical binding]; other site 137722002088 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722002089 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722002090 metal binding site [ion binding]; metal-binding site 137722002091 active site 137722002092 I-site; other site 137722002093 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722002094 Protein of unknown function DUF45; Region: DUF45; pfam01863 137722002095 PAS fold; Region: PAS_4; pfam08448 137722002096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722002097 putative active site [active] 137722002098 heme pocket [chemical binding]; other site 137722002099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722002100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722002101 dimer interface [polypeptide binding]; other site 137722002102 phosphorylation site [posttranslational modification] 137722002103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722002104 ATP binding site [chemical binding]; other site 137722002105 Mg2+ binding site [ion binding]; other site 137722002106 G-X-G motif; other site 137722002107 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722002108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722002109 active site 137722002110 phosphorylation site [posttranslational modification] 137722002111 intermolecular recognition site; other site 137722002112 dimerization interface [polypeptide binding]; other site 137722002113 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 137722002114 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 137722002115 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 137722002116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722002117 putative PBP binding loops; other site 137722002118 dimer interface [polypeptide binding]; other site 137722002119 ABC-ATPase subunit interface; other site 137722002120 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 137722002121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722002122 dimer interface [polypeptide binding]; other site 137722002123 conserved gate region; other site 137722002124 putative PBP binding loops; other site 137722002125 ABC-ATPase subunit interface; other site 137722002126 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 137722002127 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 137722002128 Walker A/P-loop; other site 137722002129 ATP binding site [chemical binding]; other site 137722002130 Q-loop/lid; other site 137722002131 ABC transporter signature motif; other site 137722002132 Walker B; other site 137722002133 D-loop; other site 137722002134 H-loop/switch region; other site 137722002135 TOBE domain; Region: TOBE_2; pfam08402 137722002136 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 137722002137 heat shock protein HtpX; Provisional; Region: PRK01345 137722002138 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 137722002139 CobD/Cbib protein; Region: CobD_Cbib; cl00561 137722002140 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 137722002141 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 137722002142 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 137722002143 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 137722002144 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722002145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 137722002146 active site 137722002147 phosphorylation site [posttranslational modification] 137722002148 intermolecular recognition site; other site 137722002149 dimerization interface [polypeptide binding]; other site 137722002150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722002151 dimer interface [polypeptide binding]; other site 137722002152 phosphorylation site [posttranslational modification] 137722002153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722002154 ATP binding site [chemical binding]; other site 137722002155 Mg2+ binding site [ion binding]; other site 137722002156 G-X-G motif; other site 137722002157 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722002158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722002159 active site 137722002160 phosphorylation site [posttranslational modification] 137722002161 intermolecular recognition site; other site 137722002162 dimerization interface [polypeptide binding]; other site 137722002163 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 137722002164 dimerization interface [polypeptide binding]; other site 137722002165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722002166 PAS fold; Region: PAS_3; pfam08447 137722002167 putative active site [active] 137722002168 heme pocket [chemical binding]; other site 137722002169 PAS domain; Region: PAS; smart00091 137722002170 PAS fold; Region: PAS_7; pfam12860 137722002171 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722002172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 137722002173 dimer interface [polypeptide binding]; other site 137722002174 phosphorylation site [posttranslational modification] 137722002175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722002176 ATP binding site [chemical binding]; other site 137722002177 Mg2+ binding site [ion binding]; other site 137722002178 G-X-G motif; other site 137722002179 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 137722002180 anti sigma factor interaction site; other site 137722002181 regulatory phosphorylation site [posttranslational modification]; other site 137722002182 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 137722002183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 137722002184 Response regulator receiver domain; Region: Response_reg; pfam00072 137722002185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722002186 active site 137722002187 phosphorylation site [posttranslational modification] 137722002188 intermolecular recognition site; other site 137722002189 dimerization interface [polypeptide binding]; other site 137722002190 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 137722002191 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 137722002192 ATP-NAD kinase; Region: NAD_kinase; pfam01513 137722002193 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 137722002194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722002195 Walker A motif; other site 137722002196 ATP binding site [chemical binding]; other site 137722002197 Walker B motif; other site 137722002198 arginine finger; other site 137722002199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722002200 Walker A motif; other site 137722002201 ATP binding site [chemical binding]; other site 137722002202 Walker B motif; other site 137722002203 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 137722002204 Uncharacterized conserved protein [Function unknown]; Region: COG2127 137722002205 Phasin protein; Region: Phasin_2; pfam09361 137722002206 Phasin protein; Region: Phasin_2; pfam09361 137722002207 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 137722002208 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 137722002209 active site 137722002210 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 137722002211 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 137722002212 Sporulation related domain; Region: SPOR; pfam05036 137722002213 Response regulator receiver domain; Region: Response_reg; pfam00072 137722002214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722002215 active site 137722002216 phosphorylation site [posttranslational modification] 137722002217 intermolecular recognition site; other site 137722002218 dimerization interface [polypeptide binding]; other site 137722002219 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 137722002220 PAS fold; Region: PAS_7; pfam12860 137722002221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722002222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722002223 dimer interface [polypeptide binding]; other site 137722002224 phosphorylation site [posttranslational modification] 137722002225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722002226 ATP binding site [chemical binding]; other site 137722002227 Mg2+ binding site [ion binding]; other site 137722002228 G-X-G motif; other site 137722002229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722002230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722002231 dimer interface [polypeptide binding]; other site 137722002232 phosphorylation site [posttranslational modification] 137722002233 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 137722002234 ATP binding site [chemical binding]; other site 137722002235 G-X-G motif; other site 137722002236 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722002237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722002238 active site 137722002239 phosphorylation site [posttranslational modification] 137722002240 intermolecular recognition site; other site 137722002241 CHASE domain; Region: CHASE; cl01369 137722002242 PAS fold; Region: PAS_4; pfam08448 137722002243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 137722002244 putative active site [active] 137722002245 heme pocket [chemical binding]; other site 137722002246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722002247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722002248 dimer interface [polypeptide binding]; other site 137722002249 phosphorylation site [posttranslational modification] 137722002250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722002251 ATP binding site [chemical binding]; other site 137722002252 Mg2+ binding site [ion binding]; other site 137722002253 G-X-G motif; other site 137722002254 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 137722002255 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 137722002256 dimer interaction site [polypeptide binding]; other site 137722002257 substrate-binding tunnel; other site 137722002258 active site 137722002259 catalytic site [active] 137722002260 substrate binding site [chemical binding]; other site 137722002261 phosphate acetyltransferase; Provisional; Region: PRK11890 137722002262 Acetokinase family; Region: Acetate_kinase; cl17229 137722002263 propionate/acetate kinase; Provisional; Region: PRK12379 137722002264 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 137722002265 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722002266 The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484 137722002267 putative dimerization interface [polypeptide binding]; other site 137722002268 putative substrate binding pocket [chemical binding]; other site 137722002269 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 137722002270 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 137722002271 active site 137722002272 dimer interface [polypeptide binding]; other site 137722002273 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 137722002274 dimer interface [polypeptide binding]; other site 137722002275 active site 137722002276 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 137722002277 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 137722002278 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 137722002279 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 137722002280 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 137722002281 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 137722002282 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 137722002283 lipoprotein signal peptidase; Provisional; Region: PRK14787 137722002284 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 137722002285 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 137722002286 active site 137722002287 HIGH motif; other site 137722002288 nucleotide binding site [chemical binding]; other site 137722002289 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 137722002290 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 137722002291 active site 137722002292 KMSKS motif; other site 137722002293 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 137722002294 tRNA binding surface [nucleotide binding]; other site 137722002295 anticodon binding site; other site 137722002296 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 137722002297 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 137722002298 TPR repeat; Region: TPR_11; pfam13414 137722002299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722002300 binding surface 137722002301 TPR motif; other site 137722002302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722002303 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 137722002304 TPR motif; other site 137722002305 binding surface 137722002306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722002307 binding surface 137722002308 TPR motif; other site 137722002309 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722002310 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 137722002311 active site 137722002312 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 137722002313 active site 137722002314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 137722002315 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722002316 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722002317 dimer interface [polypeptide binding]; other site 137722002318 putative CheW interface [polypeptide binding]; other site 137722002319 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722002320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722002321 dimerization interface [polypeptide binding]; other site 137722002322 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722002323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722002324 dimer interface [polypeptide binding]; other site 137722002325 putative CheW interface [polypeptide binding]; other site 137722002326 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 137722002327 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 137722002328 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 137722002329 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 137722002330 homotrimer interaction site [polypeptide binding]; other site 137722002331 putative active site [active] 137722002332 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 137722002333 Protein of unknown function, DUF482; Region: DUF482; pfam04339 137722002334 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 137722002335 CoA-transferase family III; Region: CoA_transf_3; pfam02515 137722002336 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 137722002337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722002338 FeS/SAM binding site; other site 137722002339 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 137722002340 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 137722002341 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722002342 dimerization interface [polypeptide binding]; other site 137722002343 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722002344 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722002345 dimer interface [polypeptide binding]; other site 137722002346 putative CheW interface [polypeptide binding]; other site 137722002347 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 137722002348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722002349 dimerization interface [polypeptide binding]; other site 137722002350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722002351 dimer interface [polypeptide binding]; other site 137722002352 conserved gate region; other site 137722002353 putative PBP binding loops; other site 137722002354 ABC-ATPase subunit interface; other site 137722002355 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 137722002356 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 137722002357 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 137722002358 GTP binding site; other site 137722002359 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 137722002360 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 137722002361 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 137722002362 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 137722002363 Formylmethanofuran dehydrogenase subunit B [Energy production and conversion]; Region: FwdB; COG1029 137722002364 [4Fe-4S] binding site [ion binding]; other site 137722002365 molybdopterin cofactor binding site; other site 137722002366 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 137722002367 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 137722002368 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 137722002369 molybdopterin cofactor binding site; other site 137722002370 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 137722002371 4Fe-4S binding domain; Region: Fer4; cl02805 137722002372 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 137722002373 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 137722002374 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 137722002375 intersubunit interface [polypeptide binding]; other site 137722002376 active site 137722002377 Zn2+ binding site [ion binding]; other site 137722002378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722002379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722002380 dimer interface [polypeptide binding]; other site 137722002381 phosphorylation site [posttranslational modification] 137722002382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722002383 ATP binding site [chemical binding]; other site 137722002384 Mg2+ binding site [ion binding]; other site 137722002385 G-X-G motif; other site 137722002386 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 137722002387 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 137722002388 putative active site [active] 137722002389 metal binding site [ion binding]; metal-binding site 137722002390 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 137722002391 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 137722002392 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 137722002393 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 137722002394 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 137722002395 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 137722002396 ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Region: ATP_synt_6_or_A; TIGR01131 137722002397 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 137722002398 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 137722002399 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 137722002400 Cu(I) binding site [ion binding]; other site 137722002401 Cache domain; Region: Cache_2; pfam08269 137722002402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 137722002403 dimerization interface [polypeptide binding]; other site 137722002404 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722002405 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722002406 dimer interface [polypeptide binding]; other site 137722002407 putative CheW interface [polypeptide binding]; other site 137722002408 Hemerythrin; Region: Hemerythrin; cd12107 137722002409 Fe binding site [ion binding]; other site 137722002410 PhoH-like protein; Region: PhoH; pfam02562 137722002411 DEAD-like helicases superfamily; Region: DEXDc; smart00487 137722002412 septum formation inhibitor; Reviewed; Region: minC; PRK00339 137722002413 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 137722002414 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 137722002415 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 137722002416 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 137722002417 P-loop; other site 137722002418 ADP binding residues [chemical binding]; other site 137722002419 Switch I; other site 137722002420 Switch II; other site 137722002421 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 137722002422 Family description; Region: VCBS; pfam13517 137722002423 Family description; Region: VCBS; pfam13517 137722002424 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 137722002425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722002426 PAS fold; Region: PAS_3; pfam08447 137722002427 putative active site [active] 137722002428 heme pocket [chemical binding]; other site 137722002429 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722002430 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722002431 dimer interface [polypeptide binding]; other site 137722002432 putative CheW interface [polypeptide binding]; other site 137722002433 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722002434 putative CheW interface [polypeptide binding]; other site 137722002435 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 137722002436 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 137722002437 active site 137722002438 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 137722002439 aromatic arch; other site 137722002440 DCoH dimer interaction site [polypeptide binding]; other site 137722002441 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 137722002442 DCoH tetramer interaction site [polypeptide binding]; other site 137722002443 substrate binding site [chemical binding]; other site 137722002444 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 137722002445 Fe-S cluster binding site [ion binding]; other site 137722002446 active site 137722002447 Predicted methyltransferase [General function prediction only]; Region: COG3897 137722002448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 137722002449 S-adenosylmethionine binding site [chemical binding]; other site 137722002450 CHAP domain; Region: CHAP; cl17642 137722002451 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 137722002452 UbiA prenyltransferase family; Region: UbiA; pfam01040 137722002453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722002454 Response regulator receiver domain; Region: Response_reg; pfam00072 137722002455 active site 137722002456 phosphorylation site [posttranslational modification] 137722002457 intermolecular recognition site; other site 137722002458 dimerization interface [polypeptide binding]; other site 137722002459 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 137722002460 RNA methyltransferase, RsmE family; Region: TIGR00046 137722002461 glutamate--cysteine ligase; Region: PLN02611 137722002462 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 137722002463 4Fe-4S binding domain; Region: Fer4; cl02805 137722002464 Rop-like; Region: Rop-like; pfam05082 137722002465 probable nitrogen fixation protein; Region: TIGR02935 137722002466 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 137722002467 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 137722002468 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 137722002469 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 137722002470 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 137722002471 Cache domain; Region: Cache_1; pfam02743 137722002472 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722002473 dimerization interface [polypeptide binding]; other site 137722002474 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722002475 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722002476 dimer interface [polypeptide binding]; other site 137722002477 putative CheW interface [polypeptide binding]; other site 137722002478 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 137722002479 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 137722002480 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 137722002481 MoFe protein beta/alpha subunit interactions; other site 137722002482 Beta subunit P cluster binding residues; other site 137722002483 MoFe protein beta subunit/Fe protein contacts; other site 137722002484 MoFe protein dimer/ dimer interactions; other site 137722002485 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 137722002486 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 137722002487 MoFe protein alpha/beta subunit interactions; other site 137722002488 Alpha subunit P cluster binding residues; other site 137722002489 FeMoco binding residues [chemical binding]; other site 137722002490 MoFe protein alpha subunit/Fe protein contacts; other site 137722002491 MoFe protein dimer/ dimer interactions; other site 137722002492 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 137722002493 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 137722002494 Nucleotide-binding sites [chemical binding]; other site 137722002495 Walker A motif; other site 137722002496 Switch I region of nucleotide binding site; other site 137722002497 Fe4S4 binding sites [ion binding]; other site 137722002498 Switch II region of nucleotide binding site; other site 137722002499 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 137722002500 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 137722002501 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 137722002502 ArsC family; Region: ArsC; pfam03960 137722002503 putative catalytic residues [active] 137722002504 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 137722002505 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 137722002506 putative active site [active] 137722002507 putative dimer interface [polypeptide binding]; other site 137722002508 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 137722002509 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 137722002510 AMP nucleosidase; Provisional; Region: PRK08292 137722002511 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 137722002512 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 137722002513 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722002514 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722002515 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 137722002516 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 137722002517 N-terminal plug; other site 137722002518 ligand-binding site [chemical binding]; other site 137722002519 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 137722002520 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 137722002521 intersubunit interface [polypeptide binding]; other site 137722002522 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 137722002523 dimer interface [polypeptide binding]; other site 137722002524 putative PBP binding regions; other site 137722002525 ABC-ATPase subunit interface; other site 137722002526 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 137722002527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722002528 Walker A/P-loop; other site 137722002529 ATP binding site [chemical binding]; other site 137722002530 Q-loop/lid; other site 137722002531 ABC transporter signature motif; other site 137722002532 Walker B; other site 137722002533 D-loop; other site 137722002534 H-loop/switch region; other site 137722002535 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 137722002536 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 137722002537 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 137722002538 CopC domain; Region: CopC; pfam04234 137722002539 Copper resistance protein D; Region: CopD; cl00563 137722002540 YtkA-like; Region: YtkA; pfam13115 137722002541 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 137722002542 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 137722002543 Cu(I) binding site [ion binding]; other site 137722002544 Protein of unknown function (DUF461); Region: DUF461; pfam04314 137722002545 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 137722002546 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 137722002547 N-terminal plug; other site 137722002548 ligand-binding site [chemical binding]; other site 137722002549 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 137722002550 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 137722002551 methanobactin biosynthesis cassette protein MbnB; Region: methbact_MbnB; TIGR04159 137722002552 Protein of unknown function (DUF692); Region: DUF692; cl01263 137722002553 AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061 137722002554 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 137722002555 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 137722002556 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 137722002557 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 137722002558 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 137722002559 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 137722002560 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 137722002561 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722002562 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722002563 ParB-like nuclease domain; Region: ParB; smart00470 137722002564 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 137722002565 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 137722002566 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 137722002567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722002568 Walker A motif; other site 137722002569 ATP binding site [chemical binding]; other site 137722002570 Walker B motif; other site 137722002571 arginine finger; other site 137722002572 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 137722002573 active site 137722002574 catalytic triad [active] 137722002575 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 137722002576 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722002577 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722002578 substrate binding pocket [chemical binding]; other site 137722002579 membrane-bound complex binding site; other site 137722002580 hinge residues; other site 137722002581 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 137722002582 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 137722002583 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 137722002584 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 137722002585 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 137722002586 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 137722002587 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 137722002588 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 137722002589 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722002590 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722002591 catalytic residue [active] 137722002592 Src homology 2 (SH2) domain; Region: SH2; cl15255 137722002593 phosphotyrosine binding pocket [polypeptide binding]; other site 137722002594 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 137722002595 Phage capsid family; Region: Phage_capsid; pfam05065 137722002596 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 137722002597 oligomer interface [polypeptide binding]; other site 137722002598 active site residues [active] 137722002599 Phage-related protein [Function unknown]; Region: COG4695; cl01923 137722002600 Phage portal protein; Region: Phage_portal; pfam04860 137722002601 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 137722002602 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 137722002603 active site 137722002604 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 137722002605 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 137722002606 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 137722002607 ParB-like nuclease domain; Region: ParBc; pfam02195 137722002608 Methyltransferase domain; Region: Methyltransf_26; pfam13659 137722002609 Helix-turn-helix domain; Region: HTH_36; pfam13730 137722002610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722002611 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 137722002612 Walker A motif; other site 137722002613 ATP binding site [chemical binding]; other site 137722002614 Walker B motif; other site 137722002615 arginine finger; other site 137722002616 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 137722002617 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 137722002618 Methyltransferase domain; Region: Methyltransf_27; pfam13708 137722002619 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 137722002620 iron-sulfur cluster [ion binding]; other site 137722002621 [2Fe-2S] cluster binding site [ion binding]; other site 137722002622 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 137722002623 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 137722002624 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 137722002625 substrate interaction site [chemical binding]; other site 137722002626 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722002627 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 137722002628 catalytic residues [active] 137722002629 catalytic nucleophile [active] 137722002630 Recombinase; Region: Recombinase; pfam07508 137722002631 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 137722002632 integrase; Provisional; Region: PRK09692 137722002633 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 137722002634 active site 137722002635 Int/Topo IB signature motif; other site 137722002636 Ferritin-like; Region: Ferritin-like; pfam12902 137722002637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722002638 FeS/SAM binding site; other site 137722002639 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 137722002640 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 137722002641 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 137722002642 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 137722002643 nickel responsive regulator; Provisional; Region: PRK02967 137722002644 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 137722002645 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 137722002646 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 137722002647 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 137722002648 substrate binding site [chemical binding]; other site 137722002649 nickel transporter permease NikB; Provisional; Region: PRK10352 137722002650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722002651 dimer interface [polypeptide binding]; other site 137722002652 conserved gate region; other site 137722002653 putative PBP binding loops; other site 137722002654 ABC-ATPase subunit interface; other site 137722002655 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 137722002656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722002657 dimer interface [polypeptide binding]; other site 137722002658 conserved gate region; other site 137722002659 putative PBP binding loops; other site 137722002660 ABC-ATPase subunit interface; other site 137722002661 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 137722002662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722002663 Walker A/P-loop; other site 137722002664 ATP binding site [chemical binding]; other site 137722002665 Q-loop/lid; other site 137722002666 ABC transporter signature motif; other site 137722002667 Walker B; other site 137722002668 D-loop; other site 137722002669 H-loop/switch region; other site 137722002670 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 137722002671 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722002672 Walker A/P-loop; other site 137722002673 ATP binding site [chemical binding]; other site 137722002674 Q-loop/lid; other site 137722002675 ABC transporter signature motif; other site 137722002676 Walker B; other site 137722002677 D-loop; other site 137722002678 H-loop/switch region; other site 137722002679 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722002680 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722002681 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722002682 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722002683 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 137722002684 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 137722002685 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 137722002686 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 137722002687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722002688 FeS/SAM binding site; other site 137722002689 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 137722002690 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 137722002691 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 137722002692 Predicted membrane protein [Function unknown]; Region: COG2246 137722002693 GtrA-like protein; Region: GtrA; pfam04138 137722002694 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 137722002695 Ligand binding site; other site 137722002696 Putative Catalytic site; other site 137722002697 DXD motif; other site 137722002698 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 137722002699 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 137722002700 substrate binding site [chemical binding]; other site 137722002701 tartrate dehydrogenase; Region: TTC; TIGR02089 137722002702 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 137722002703 General stress protein [General function prediction only]; Region: GsiB; COG3729 137722002704 Response regulator receiver domain; Region: Response_reg; pfam00072 137722002705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722002706 active site 137722002707 phosphorylation site [posttranslational modification] 137722002708 intermolecular recognition site; other site 137722002709 dimerization interface [polypeptide binding]; other site 137722002710 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 137722002711 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 137722002712 pyridoxamine kinase; Validated; Region: PRK05756 137722002713 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 137722002714 dimer interface [polypeptide binding]; other site 137722002715 pyridoxal binding site [chemical binding]; other site 137722002716 ATP binding site [chemical binding]; other site 137722002717 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 137722002718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722002719 putative active site [active] 137722002720 heme pocket [chemical binding]; other site 137722002721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722002722 dimer interface [polypeptide binding]; other site 137722002723 phosphorylation site [posttranslational modification] 137722002724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722002725 ATP binding site [chemical binding]; other site 137722002726 Mg2+ binding site [ion binding]; other site 137722002727 G-X-G motif; other site 137722002728 Predicted ATPase [General function prediction only]; Region: COG1485 137722002729 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 137722002730 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 137722002731 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 137722002732 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 137722002733 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722002734 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722002735 dimerization interface [polypeptide binding]; other site 137722002736 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722002737 dimer interface [polypeptide binding]; other site 137722002738 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 137722002739 putative CheW interface [polypeptide binding]; other site 137722002740 lipoyl synthase; Provisional; Region: PRK05481 137722002741 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722002742 FeS/SAM binding site; other site 137722002743 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 137722002744 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 137722002745 putative NAD(P) binding site [chemical binding]; other site 137722002746 catalytic Zn binding site [ion binding]; other site 137722002747 acetoin reductases; Region: 23BDH; TIGR02415 137722002748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722002749 NAD(P) binding site [chemical binding]; other site 137722002750 active site 137722002751 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 137722002752 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 137722002753 E3 interaction surface; other site 137722002754 lipoyl attachment site [posttranslational modification]; other site 137722002755 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 137722002756 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 137722002757 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 137722002758 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 137722002759 alpha subunit interface [polypeptide binding]; other site 137722002760 TPP binding site [chemical binding]; other site 137722002761 heterodimer interface [polypeptide binding]; other site 137722002762 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 137722002763 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 137722002764 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 137722002765 tetramer interface [polypeptide binding]; other site 137722002766 TPP-binding site [chemical binding]; other site 137722002767 heterodimer interface [polypeptide binding]; other site 137722002768 phosphorylation loop region [posttranslational modification] 137722002769 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 137722002770 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 137722002771 FAD binding domain; Region: FAD_binding_4; pfam01565 137722002772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 137722002773 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 137722002774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722002775 Walker A/P-loop; other site 137722002776 ATP binding site [chemical binding]; other site 137722002777 Q-loop/lid; other site 137722002778 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 137722002779 ABC transporter; Region: ABC_tran_2; pfam12848 137722002780 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 137722002781 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722002782 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722002783 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 137722002784 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722002785 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722002786 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722002787 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 137722002788 VacJ like lipoprotein; Region: VacJ; cl01073 137722002789 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722002790 putative DNA binding site [nucleotide binding]; other site 137722002791 putative Zn2+ binding site [ion binding]; other site 137722002792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722002793 Methyltransferase domain; Region: Methyltransf_31; pfam13847 137722002794 S-adenosylmethionine binding site [chemical binding]; other site 137722002795 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 137722002796 FAD binding site [chemical binding]; other site 137722002797 Domain of unknown function DUF29; Region: DUF29; pfam01724 137722002798 Domain of unknown function DUF29; Region: DUF29; pfam01724 137722002799 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 137722002800 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 137722002801 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 137722002802 substrate binding pocket [chemical binding]; other site 137722002803 dimer interface [polypeptide binding]; other site 137722002804 inhibitor binding site; inhibition site 137722002805 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 137722002806 B12 binding site [chemical binding]; other site 137722002807 cobalt ligand [ion binding]; other site 137722002808 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 137722002809 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 137722002810 active site 137722002811 NTP binding site [chemical binding]; other site 137722002812 metal binding triad [ion binding]; metal-binding site 137722002813 antibiotic binding site [chemical binding]; other site 137722002814 HEPN domain; Region: HEPN; pfam05168 137722002815 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 137722002816 active site 137722002817 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 137722002818 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722002819 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722002820 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722002821 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722002822 metal binding site [ion binding]; metal-binding site 137722002823 active site 137722002824 I-site; other site 137722002825 Nitronate monooxygenase; Region: NMO; pfam03060 137722002826 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 137722002827 FMN binding site [chemical binding]; other site 137722002828 substrate binding site [chemical binding]; other site 137722002829 putative catalytic residue [active] 137722002830 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 137722002831 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 137722002832 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 137722002833 ABC transporter; Region: ABC_tran_2; pfam12848 137722002834 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 137722002835 Protein of unknown function (DUF466); Region: DUF466; pfam04328 137722002836 carbon starvation protein A; Provisional; Region: PRK15015 137722002837 Carbon starvation protein CstA; Region: CstA; pfam02554 137722002838 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 137722002839 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 137722002840 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 137722002841 CysD dimerization site [polypeptide binding]; other site 137722002842 G1 box; other site 137722002843 putative GEF interaction site [polypeptide binding]; other site 137722002844 GTP/Mg2+ binding site [chemical binding]; other site 137722002845 Switch I region; other site 137722002846 G2 box; other site 137722002847 G3 box; other site 137722002848 Switch II region; other site 137722002849 G4 box; other site 137722002850 G5 box; other site 137722002851 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 137722002852 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 137722002853 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 137722002854 ligand-binding site [chemical binding]; other site 137722002855 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 137722002856 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 137722002857 Active Sites [active] 137722002858 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 137722002859 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 137722002860 Active Sites [active] 137722002861 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 137722002862 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 137722002863 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 137722002864 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 137722002865 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 137722002866 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 137722002867 Homeodomain-like domain; Region: HTH_23; pfam13384 137722002868 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 137722002869 Peptidase M15; Region: Peptidase_M15_3; cl01194 137722002870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 137722002871 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 137722002872 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 137722002873 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722002874 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722002875 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 137722002876 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722002877 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 137722002878 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722002879 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722002880 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722002881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722002882 dimer interface [polypeptide binding]; other site 137722002883 phosphorylation site [posttranslational modification] 137722002884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722002885 ATP binding site [chemical binding]; other site 137722002886 Mg2+ binding site [ion binding]; other site 137722002887 G-X-G motif; other site 137722002888 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 137722002889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722002890 active site 137722002891 phosphorylation site [posttranslational modification] 137722002892 intermolecular recognition site; other site 137722002893 dimerization interface [polypeptide binding]; other site 137722002894 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722002895 DNA binding residues [nucleotide binding] 137722002896 dimerization interface [polypeptide binding]; other site 137722002897 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722002898 putative active site [active] 137722002899 heme pocket [chemical binding]; other site 137722002900 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722002901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 137722002902 dimer interface [polypeptide binding]; other site 137722002903 phosphorylation site [posttranslational modification] 137722002904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722002905 ATP binding site [chemical binding]; other site 137722002906 Mg2+ binding site [ion binding]; other site 137722002907 G-X-G motif; other site 137722002908 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 137722002909 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 137722002910 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 137722002911 DctM-like transporters; Region: DctM; pfam06808 137722002912 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 137722002913 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 137722002914 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 137722002915 putative [4Fe-4S] binding site [ion binding]; other site 137722002916 putative molybdopterin cofactor binding site [chemical binding]; other site 137722002917 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 137722002918 molybdopterin cofactor binding site; other site 137722002919 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 137722002920 DHH family; Region: DHH; pfam01368 137722002921 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; cl17853 137722002922 DHHA1 domain; Region: DHHA1; pfam02272 137722002923 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 137722002924 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 137722002925 FMN binding site [chemical binding]; other site 137722002926 active site 137722002927 catalytic residues [active] 137722002928 substrate binding site [chemical binding]; other site 137722002929 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722002930 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722002931 dimer interface [polypeptide binding]; other site 137722002932 putative CheW interface [polypeptide binding]; other site 137722002933 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 137722002934 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 137722002935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722002936 catalytic residue [active] 137722002937 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 137722002938 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 137722002939 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 137722002940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 137722002941 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 137722002942 hypothetical protein; Validated; Region: PRK09039 137722002943 hypothetical protein; Validated; Region: PRK09039 137722002944 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 137722002945 ligand binding site [chemical binding]; other site 137722002946 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 137722002947 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 137722002948 active site 137722002949 dimerization interface [polypeptide binding]; other site 137722002950 elongation factor P; Validated; Region: PRK00529 137722002951 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 137722002952 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 137722002953 RNA binding site [nucleotide binding]; other site 137722002954 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 137722002955 RNA binding site [nucleotide binding]; other site 137722002956 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 137722002957 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 137722002958 motif 1; other site 137722002959 dimer interface [polypeptide binding]; other site 137722002960 active site 137722002961 motif 2; other site 137722002962 motif 3; other site 137722002963 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 137722002964 hypothetical protein; Provisional; Region: PRK10621 137722002965 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 137722002966 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 137722002967 active site 137722002968 thiamine phosphate binding site [chemical binding]; other site 137722002969 pyrophosphate binding site [ion binding]; other site 137722002970 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 137722002971 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 137722002972 putative active site; other site 137722002973 catalytic residue [active] 137722002974 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 137722002975 HicB family; Region: HicB; pfam05534 137722002976 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 137722002977 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 137722002978 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722002979 dimerization interface [polypeptide binding]; other site 137722002980 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722002981 dimer interface [polypeptide binding]; other site 137722002982 putative CheW interface [polypeptide binding]; other site 137722002983 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722002984 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722002985 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 137722002986 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 137722002987 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 137722002988 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 137722002989 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 137722002990 TPP-binding site [chemical binding]; other site 137722002991 dimer interface [polypeptide binding]; other site 137722002992 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 137722002993 PYR/PP interface [polypeptide binding]; other site 137722002994 dimer interface [polypeptide binding]; other site 137722002995 TPP binding site [chemical binding]; other site 137722002996 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 137722002997 Cell division protein ZapA; Region: ZapA; pfam05164 137722002998 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 137722002999 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 137722003000 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 137722003001 putative active site [active] 137722003002 metal binding site [ion binding]; metal-binding site 137722003003 homodimer binding site [polypeptide binding]; other site 137722003004 hypothetical protein; Validated; Region: PRK00110 137722003005 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 137722003006 active site 137722003007 putative DNA-binding cleft [nucleotide binding]; other site 137722003008 dimer interface [polypeptide binding]; other site 137722003009 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 137722003010 putative active site [active] 137722003011 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 137722003012 RuvA N terminal domain; Region: RuvA_N; pfam01330 137722003013 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 137722003014 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 137722003015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722003016 Walker A motif; other site 137722003017 ATP binding site [chemical binding]; other site 137722003018 Walker B motif; other site 137722003019 arginine finger; other site 137722003020 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 137722003021 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 137722003022 active site 137722003023 TolQ protein; Region: tolQ; TIGR02796 137722003024 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 137722003025 TolR protein; Region: tolR; TIGR02801 137722003026 translocation protein TolB; Provisional; Region: tolB; PRK05137 137722003027 TolB amino-terminal domain; Region: TolB_N; pfam04052 137722003028 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 137722003029 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 137722003030 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 137722003031 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 137722003032 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 137722003033 ligand binding site [chemical binding]; other site 137722003034 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 137722003035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722003036 binding surface 137722003037 TPR motif; other site 137722003038 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 137722003039 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 137722003040 FtsH Extracellular; Region: FtsH_ext; pfam06480 137722003041 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 137722003042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722003043 Walker A motif; other site 137722003044 ATP binding site [chemical binding]; other site 137722003045 Walker B motif; other site 137722003046 arginine finger; other site 137722003047 Peptidase family M41; Region: Peptidase_M41; pfam01434 137722003048 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 137722003049 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 137722003050 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 137722003051 NAD binding site [chemical binding]; other site 137722003052 homotetramer interface [polypeptide binding]; other site 137722003053 homodimer interface [polypeptide binding]; other site 137722003054 substrate binding site [chemical binding]; other site 137722003055 active site 137722003056 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 137722003057 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 137722003058 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 137722003059 HSP70 interaction site [polypeptide binding]; other site 137722003060 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 137722003061 substrate binding site [polypeptide binding]; other site 137722003062 dimer interface [polypeptide binding]; other site 137722003063 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 137722003064 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 137722003065 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 137722003066 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 137722003067 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 137722003068 Cation efflux family; Region: Cation_efflux; cl00316 137722003069 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722003070 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722003071 dimer interface [polypeptide binding]; other site 137722003072 putative CheW interface [polypeptide binding]; other site 137722003073 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 137722003074 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 137722003075 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 137722003076 Ligand Binding Site [chemical binding]; other site 137722003077 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 137722003078 Ligand Binding Site [chemical binding]; other site 137722003079 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722003080 CHASE3 domain; Region: CHASE3; pfam05227 137722003081 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722003082 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722003083 dimer interface [polypeptide binding]; other site 137722003084 putative CheW interface [polypeptide binding]; other site 137722003085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 137722003086 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 137722003087 dimerization interface [polypeptide binding]; other site 137722003088 metal binding site [ion binding]; metal-binding site 137722003089 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 137722003090 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 137722003091 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 137722003092 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 137722003093 dimer interface [polypeptide binding]; other site 137722003094 active site 137722003095 glycine-pyridoxal phosphate binding site [chemical binding]; other site 137722003096 folate binding site [chemical binding]; other site 137722003097 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 137722003098 ATP cone domain; Region: ATP-cone; pfam03477 137722003099 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 137722003100 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 137722003101 thiamine monophosphate kinase; Provisional; Region: PRK05731 137722003102 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 137722003103 ATP binding site [chemical binding]; other site 137722003104 dimerization interface [polypeptide binding]; other site 137722003105 transcription antitermination factor NusB; Region: nusB; TIGR01951 137722003106 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 137722003107 homopentamer interface [polypeptide binding]; other site 137722003108 active site 137722003109 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 137722003110 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 137722003111 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 137722003112 dimerization interface [polypeptide binding]; other site 137722003113 active site 137722003114 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 137722003115 Lumazine binding domain; Region: Lum_binding; pfam00677 137722003116 Lumazine binding domain; Region: Lum_binding; pfam00677 137722003117 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 137722003118 catalytic motif [active] 137722003119 Zn binding site [ion binding]; other site 137722003120 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 137722003121 RibD C-terminal domain; Region: RibD_C; cl17279 137722003122 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 137722003123 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 137722003124 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981 137722003125 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 137722003126 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 137722003127 putative phosphate acyltransferase; Provisional; Region: PRK05331 137722003128 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 137722003129 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 137722003130 dimer interface [polypeptide binding]; other site 137722003131 active site 137722003132 CoA binding pocket [chemical binding]; other site 137722003133 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 137722003134 IHF dimer interface [polypeptide binding]; other site 137722003135 IHF - DNA interface [nucleotide binding]; other site 137722003136 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 137722003137 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 137722003138 DNA binding residues [nucleotide binding] 137722003139 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 137722003140 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722003141 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722003142 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722003143 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722003144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 137722003145 Transposase; Region: DDE_Tnp_ISL3; pfam01610 137722003146 Homeodomain-like domain; Region: HTH_23; pfam13384 137722003147 Transposase; Region: DDE_Tnp_ISL3; pfam01610 137722003148 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 137722003149 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722003150 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722003151 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 137722003152 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 137722003153 CRISPR-associated protein; Region: TIGR03986 137722003154 CRISPR-associated protein; Region: TIGR03986 137722003155 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 137722003156 CRISPR associated protein Cas2; Region: CRISPR_Cas2; pfam09827 137722003157 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 137722003158 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 137722003159 putative active site [active] 137722003160 putative NTP binding site [chemical binding]; other site 137722003161 putative nucleic acid binding site [nucleotide binding]; other site 137722003162 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 137722003163 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 137722003164 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722003165 MarR family; Region: MarR; pfam01047 137722003166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722003167 Coenzyme A binding pocket [chemical binding]; other site 137722003168 HemK family putative methylases; Region: hemK_fam; TIGR00536 137722003169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722003170 S-adenosylmethionine binding site [chemical binding]; other site 137722003171 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 137722003172 ArsC family; Region: ArsC; pfam03960 137722003173 catalytic residues [active] 137722003174 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 137722003175 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 137722003176 ligand binding site [chemical binding]; other site 137722003177 NAD binding site [chemical binding]; other site 137722003178 tetramer interface [polypeptide binding]; other site 137722003179 catalytic site [active] 137722003180 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 137722003181 L-serine binding site [chemical binding]; other site 137722003182 ACT domain interface; other site 137722003183 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 137722003184 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 137722003185 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 137722003186 EamA-like transporter family; Region: EamA; pfam00892 137722003187 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 137722003188 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 137722003189 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 137722003190 catalytic site [active] 137722003191 subunit interface [polypeptide binding]; other site 137722003192 Yqey-like protein; Region: YqeY; pfam09424 137722003193 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 137722003194 putative active site [active] 137722003195 CHC2 zinc finger; Region: zf-CHC2; cl17510 137722003196 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 137722003197 DNA primase; Validated; Region: dnaG; PRK05667 137722003198 CHC2 zinc finger; Region: zf-CHC2; cl17510 137722003199 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 137722003200 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 137722003201 active site 137722003202 metal binding site [ion binding]; metal-binding site 137722003203 interdomain interaction site; other site 137722003204 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 137722003205 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 137722003206 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 137722003207 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 137722003208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722003209 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 137722003210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722003211 DNA binding residues [nucleotide binding] 137722003212 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 137722003213 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722003214 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722003215 DNA binding residues [nucleotide binding] 137722003216 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 137722003217 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 137722003218 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 137722003219 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 137722003220 hydrophobic ligand binding site; other site 137722003221 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 137722003222 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 137722003223 NAD binding site [chemical binding]; other site 137722003224 catalytic Zn binding site [ion binding]; other site 137722003225 structural Zn binding site [ion binding]; other site 137722003226 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 137722003227 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 137722003228 NodB motif; other site 137722003229 active site 137722003230 catalytic site [active] 137722003231 metal binding site [ion binding]; metal-binding site 137722003232 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 137722003233 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 137722003234 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 137722003235 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 137722003236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 137722003237 Peptidase M15; Region: Peptidase_M15_3; cl01194 137722003238 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722003239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722003240 non-specific DNA binding site [nucleotide binding]; other site 137722003241 salt bridge; other site 137722003242 sequence-specific DNA binding site [nucleotide binding]; other site 137722003243 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 137722003244 G1 box; other site 137722003245 GTP/Mg2+ binding site [chemical binding]; other site 137722003246 G2 box; other site 137722003247 Switch I region; other site 137722003248 G3 box; other site 137722003249 Switch II region; other site 137722003250 G4 box; other site 137722003251 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 137722003252 Dehydroquinase class II; Region: DHquinase_II; pfam01220 137722003253 trimer interface [polypeptide binding]; other site 137722003254 active site 137722003255 dimer interface [polypeptide binding]; other site 137722003256 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 137722003257 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 137722003258 carboxyltransferase (CT) interaction site; other site 137722003259 biotinylation site [posttranslational modification]; other site 137722003260 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 137722003261 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 137722003262 ATP-grasp domain; Region: ATP-grasp_4; cl17255 137722003263 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 137722003264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722003265 PAS domain; Region: PAS_9; pfam13426 137722003266 putative active site [active] 137722003267 heme pocket [chemical binding]; other site 137722003268 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722003269 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 137722003270 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722003271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722003272 dimer interface [polypeptide binding]; other site 137722003273 putative CheW interface [polypeptide binding]; other site 137722003274 PilZ domain; Region: PilZ; pfam07238 137722003275 Response regulator receiver domain; Region: Response_reg; pfam00072 137722003276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722003277 active site 137722003278 phosphorylation site [posttranslational modification] 137722003279 intermolecular recognition site; other site 137722003280 dimerization interface [polypeptide binding]; other site 137722003281 NifQ; Region: NifQ; pfam04891 137722003282 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 137722003283 putative hydrophobic ligand binding site [chemical binding]; other site 137722003284 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 137722003285 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 137722003286 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 137722003287 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 137722003288 protein binding site [polypeptide binding]; other site 137722003289 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 137722003290 protein binding site [polypeptide binding]; other site 137722003291 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 137722003292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722003293 active site 137722003294 phosphorylation site [posttranslational modification] 137722003295 intermolecular recognition site; other site 137722003296 dimerization interface [polypeptide binding]; other site 137722003297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722003298 DNA binding site [nucleotide binding] 137722003299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722003300 dimerization interface [polypeptide binding]; other site 137722003301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722003302 dimer interface [polypeptide binding]; other site 137722003303 phosphorylation site [posttranslational modification] 137722003304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722003305 ATP binding site [chemical binding]; other site 137722003306 Mg2+ binding site [ion binding]; other site 137722003307 G-X-G motif; other site 137722003308 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 137722003309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722003310 putative substrate translocation pore; other site 137722003311 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 137722003312 tandem repeat interface [polypeptide binding]; other site 137722003313 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 137722003314 oligomer interface [polypeptide binding]; other site 137722003315 active site residues [active] 137722003316 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 137722003317 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 137722003318 tandem repeat interface [polypeptide binding]; other site 137722003319 oligomer interface [polypeptide binding]; other site 137722003320 active site residues [active] 137722003321 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 137722003322 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 137722003323 Response regulator receiver domain; Region: Response_reg; pfam00072 137722003324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722003325 active site 137722003326 phosphorylation site [posttranslational modification] 137722003327 intermolecular recognition site; other site 137722003328 dimerization interface [polypeptide binding]; other site 137722003329 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 137722003330 Nitrate and nitrite sensing; Region: NIT; pfam08376 137722003331 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 137722003332 HAMP domain; Region: HAMP; pfam00672 137722003333 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722003334 putative CheW interface [polypeptide binding]; other site 137722003335 aminotransferase; Validated; Region: PRK09148 137722003336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722003337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722003338 homodimer interface [polypeptide binding]; other site 137722003339 catalytic residue [active] 137722003340 homoserine dehydrogenase; Provisional; Region: PRK06349 137722003341 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 137722003342 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 137722003343 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 137722003344 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 137722003345 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 137722003346 putative active site [active] 137722003347 Carboxylesterase family; Region: COesterase; pfam00135 137722003348 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 137722003349 substrate binding pocket [chemical binding]; other site 137722003350 catalytic triad [active] 137722003351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722003352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722003353 dimer interface [polypeptide binding]; other site 137722003354 phosphorylation site [posttranslational modification] 137722003355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722003356 ATP binding site [chemical binding]; other site 137722003357 Mg2+ binding site [ion binding]; other site 137722003358 G-X-G motif; other site 137722003359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722003360 active site 137722003361 phosphorylation site [posttranslational modification] 137722003362 intermolecular recognition site; other site 137722003363 dimerization interface [polypeptide binding]; other site 137722003364 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 137722003365 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 137722003366 dimer interface [polypeptide binding]; other site 137722003367 putative functional site; other site 137722003368 putative MPT binding site; other site 137722003369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722003370 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 137722003371 putative dimerization interface [polypeptide binding]; other site 137722003372 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 137722003373 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 137722003374 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 137722003375 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 137722003376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722003377 binding surface 137722003378 TPR motif; other site 137722003379 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 137722003380 MG2 domain; Region: A2M_N; pfam01835 137722003381 Alpha-2-macroglobulin family; Region: A2M; pfam00207 137722003382 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 137722003383 surface patch; other site 137722003384 thioester region; other site 137722003385 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 137722003386 Transglycosylase; Region: Transgly; pfam00912 137722003387 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 137722003388 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 137722003389 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 137722003390 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 137722003391 Multicopper oxidase; Region: Cu-oxidase; pfam00394 137722003392 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 137722003393 SlyX; Region: SlyX; pfam04102 137722003394 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 137722003395 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 137722003396 DEAD-like helicases superfamily; Region: DEXDc; smart00487 137722003397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 137722003398 ATP binding site [chemical binding]; other site 137722003399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722003400 nucleotide binding region [chemical binding]; other site 137722003401 ATP-binding site [chemical binding]; other site 137722003402 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 137722003403 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 137722003404 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 137722003405 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 137722003406 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 137722003407 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 137722003408 Protein export membrane protein; Region: SecD_SecF; cl14618 137722003409 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 137722003410 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722003411 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 137722003412 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722003413 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722003414 catalytic residue [active] 137722003415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722003416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722003417 LysR substrate binding domain; Region: LysR_substrate; pfam03466 137722003418 dimerization interface [polypeptide binding]; other site 137722003419 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722003420 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 137722003421 LysR family transcriptional regulator; Provisional; Region: PRK14997 137722003422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722003423 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 137722003424 putative effector binding pocket; other site 137722003425 dimerization interface [polypeptide binding]; other site 137722003426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722003427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722003428 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 137722003429 putative effector binding pocket; other site 137722003430 putative dimerization interface [polypeptide binding]; other site 137722003431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722003432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722003433 putative substrate translocation pore; other site 137722003434 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 137722003435 Beta-lactamase; Region: Beta-lactamase; pfam00144 137722003436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722003437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722003438 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 137722003439 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 137722003440 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 137722003441 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722003442 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722003443 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 137722003444 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722003445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 137722003446 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 137722003447 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 137722003448 putative di-iron ligands [ion binding]; other site 137722003449 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 137722003450 CheB methylesterase; Region: CheB_methylest; pfam01339 137722003451 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 137722003452 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 137722003453 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 137722003454 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 137722003455 PAS domain; Region: PAS_10; pfam13596 137722003456 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 137722003457 GAF domain; Region: GAF_3; pfam13492 137722003458 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722003459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722003460 dimer interface [polypeptide binding]; other site 137722003461 phosphorylation site [posttranslational modification] 137722003462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722003463 ATP binding site [chemical binding]; other site 137722003464 Mg2+ binding site [ion binding]; other site 137722003465 G-X-G motif; other site 137722003466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722003467 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722003468 active site 137722003469 phosphorylation site [posttranslational modification] 137722003470 intermolecular recognition site; other site 137722003471 dimerization interface [polypeptide binding]; other site 137722003472 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 137722003473 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 137722003474 TrkA-N domain; Region: TrkA_N; pfam02254 137722003475 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 137722003476 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 137722003477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 137722003478 Transposase; Region: DDE_Tnp_ISL3; pfam01610 137722003479 Transposase; Region: DDE_Tnp_ISL3; pfam01610 137722003480 ParB-like nuclease domain; Region: ParB; smart00470 137722003481 Methyltransferase domain; Region: Methyltransf_26; pfam13659 137722003482 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 137722003483 Helicase_C-like; Region: Helicase_C_4; pfam13871 137722003484 Toprim-like; Region: Toprim_2; pfam13155 137722003485 active site 137722003486 metal binding site [ion binding]; metal-binding site 137722003487 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 137722003488 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722003489 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722003490 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722003491 Transposase domain (DUF772); Region: DUF772; pfam05598 137722003492 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722003493 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 137722003494 Helix-turn-helix domain; Region: HTH_17; pfam12728 137722003495 Replication initiator protein A; Region: RPA; pfam10134 137722003496 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 137722003497 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722003498 P-loop; other site 137722003499 Magnesium ion binding site [ion binding]; other site 137722003500 ParA-like protein; Provisional; Region: PHA02518 137722003501 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722003502 P-loop; other site 137722003503 Magnesium ion binding site [ion binding]; other site 137722003504 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 137722003505 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 137722003506 Walker A motif; other site 137722003507 ATP binding site [chemical binding]; other site 137722003508 Walker B motif; other site 137722003509 Type II/IV secretion system protein; Region: T2SE; pfam00437 137722003510 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 137722003511 Walker A motif; other site 137722003512 ATP binding site [chemical binding]; other site 137722003513 Walker B motif; other site 137722003514 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 137722003515 conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193 137722003516 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 137722003517 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 137722003518 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 137722003519 VirB7 interaction site; other site 137722003520 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 137722003521 Domain of unknown function DUF87; Region: DUF87; pfam01935 137722003522 HerA helicase [Replication, recombination, and repair]; Region: COG0433 137722003523 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722003524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722003525 Walker A motif; other site 137722003526 ATP binding site [chemical binding]; other site 137722003527 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722003528 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722003529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722003530 Integrase core domain; Region: rve; pfam00665 137722003531 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 137722003532 integrase; Provisional; Region: PRK09692 137722003533 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 137722003534 active site 137722003535 Int/Topo IB signature motif; other site 137722003536 GMP synthase; Reviewed; Region: guaA; PRK00074 137722003537 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 137722003538 AMP/PPi binding site [chemical binding]; other site 137722003539 candidate oxyanion hole; other site 137722003540 catalytic triad [active] 137722003541 potential glutamine specificity residues [chemical binding]; other site 137722003542 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 137722003543 ATP Binding subdomain [chemical binding]; other site 137722003544 Ligand Binding sites [chemical binding]; other site 137722003545 Dimerization subdomain; other site 137722003546 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 137722003547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722003548 Coenzyme A binding pocket [chemical binding]; other site 137722003549 Predicted permeases [General function prediction only]; Region: COG0795 137722003550 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 137722003551 SurA N-terminal domain; Region: SurA_N; pfam09312 137722003552 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 137722003553 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 137722003554 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 137722003555 Uncharacterized conserved protein [Function unknown]; Region: COG1432 137722003556 LabA_like proteins; Region: LabA; cd10911 137722003557 putative metal binding site [ion binding]; other site 137722003558 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 137722003559 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 137722003560 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 137722003561 Zn2+ binding site [ion binding]; other site 137722003562 Mg2+ binding site [ion binding]; other site 137722003563 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 137722003564 synthetase active site [active] 137722003565 NTP binding site [chemical binding]; other site 137722003566 metal binding site [ion binding]; metal-binding site 137722003567 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 137722003568 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 137722003569 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 137722003570 active site 137722003571 hydrophilic channel; other site 137722003572 dimerization interface [polypeptide binding]; other site 137722003573 catalytic residues [active] 137722003574 active site lid [active] 137722003575 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 137722003576 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 137722003577 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 137722003578 Catalytic site [active] 137722003579 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 137722003580 ribonuclease III; Reviewed; Region: rnc; PRK00102 137722003581 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 137722003582 dimerization interface [polypeptide binding]; other site 137722003583 active site 137722003584 metal binding site [ion binding]; metal-binding site 137722003585 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 137722003586 dsRNA binding site [nucleotide binding]; other site 137722003587 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 137722003588 GTPase Era; Reviewed; Region: era; PRK00089 137722003589 G1 box; other site 137722003590 GTP/Mg2+ binding site [chemical binding]; other site 137722003591 Switch I region; other site 137722003592 G2 box; other site 137722003593 Switch II region; other site 137722003594 G3 box; other site 137722003595 G4 box; other site 137722003596 G5 box; other site 137722003597 KH domain; Region: KH_2; pfam07650 137722003598 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 137722003599 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 137722003600 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 137722003601 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722003602 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 137722003603 catalytic residues [active] 137722003604 catalytic nucleophile [active] 137722003605 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722003606 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 137722003607 active site 137722003608 catalytic residues [active] 137722003609 DNA binding site [nucleotide binding] 137722003610 Int/Topo IB signature motif; other site 137722003611 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 137722003612 active site 137722003613 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 137722003614 active site 137722003615 nucleophile elbow; other site 137722003616 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 137722003617 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 137722003618 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 137722003619 ligand binding site [chemical binding]; other site 137722003620 Tetratricopeptide repeat; Region: TPR_16; pfam13432 137722003621 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 137722003622 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 137722003623 Fasciclin domain; Region: Fasciclin; pfam02469 137722003624 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 137722003625 potassium uptake protein; Region: kup; TIGR00794 137722003626 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 137722003627 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 137722003628 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 137722003629 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 137722003630 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 137722003631 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 137722003632 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 137722003633 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 137722003634 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 137722003635 flagellar biosynthetic protein FliQ; Region: fliQ; TIGR01402 137722003636 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 137722003637 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 137722003638 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 137722003639 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 137722003640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722003641 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 137722003642 putative active site [active] 137722003643 heme pocket [chemical binding]; other site 137722003644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722003645 dimer interface [polypeptide binding]; other site 137722003646 phosphorylation site [posttranslational modification] 137722003647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722003648 ATP binding site [chemical binding]; other site 137722003649 Mg2+ binding site [ion binding]; other site 137722003650 G-X-G motif; other site 137722003651 Response regulator receiver domain; Region: Response_reg; pfam00072 137722003652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722003653 active site 137722003654 phosphorylation site [posttranslational modification] 137722003655 intermolecular recognition site; other site 137722003656 dimerization interface [polypeptide binding]; other site 137722003657 recombinase A; Provisional; Region: recA; PRK09354 137722003658 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 137722003659 hexamer interface [polypeptide binding]; other site 137722003660 Walker A motif; other site 137722003661 ATP binding site [chemical binding]; other site 137722003662 Walker B motif; other site 137722003663 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 137722003664 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 137722003665 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 137722003666 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 137722003667 Ligand binding site; other site 137722003668 DXD motif; other site 137722003669 HIT domain; Region: HIT; pfam01230 137722003670 nucleotide binding site/active site [active] 137722003671 HIT family signature motif; other site 137722003672 catalytic residue [active] 137722003673 Family description; Region: ACT_7; pfam13840 137722003674 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 137722003675 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 137722003676 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 137722003677 ATP binding site [chemical binding]; other site 137722003678 putative Mg++ binding site [ion binding]; other site 137722003679 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722003680 nucleotide binding region [chemical binding]; other site 137722003681 ATP-binding site [chemical binding]; other site 137722003682 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 137722003683 Uncharacterized conserved protein [Function unknown]; Region: COG2938 137722003684 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 137722003685 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 137722003686 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 137722003687 protease TldD; Provisional; Region: tldD; PRK10735 137722003688 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 137722003689 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 137722003690 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 137722003691 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 137722003692 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 137722003693 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 137722003694 Subunit I/III interface [polypeptide binding]; other site 137722003695 D-pathway; other site 137722003696 Subunit I/VIIc interface [polypeptide binding]; other site 137722003697 Subunit I/IV interface [polypeptide binding]; other site 137722003698 Subunit I/II interface [polypeptide binding]; other site 137722003699 Low-spin heme (heme a) binding site [chemical binding]; other site 137722003700 Subunit I/VIIa interface [polypeptide binding]; other site 137722003701 Subunit I/VIa interface [polypeptide binding]; other site 137722003702 Dimer interface; other site 137722003703 Putative water exit pathway; other site 137722003704 Binuclear center (heme a3/CuB) [ion binding]; other site 137722003705 K-pathway; other site 137722003706 Subunit I/Vb interface [polypeptide binding]; other site 137722003707 Putative proton exit pathway; other site 137722003708 Subunit I/VIb interface; other site 137722003709 Subunit I/VIc interface [polypeptide binding]; other site 137722003710 Electron transfer pathway; other site 137722003711 Subunit I/VIIIb interface [polypeptide binding]; other site 137722003712 Subunit I/VIIb interface [polypeptide binding]; other site 137722003713 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 137722003714 UbiA prenyltransferase family; Region: UbiA; pfam01040 137722003715 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 137722003716 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 137722003717 Subunit III/VIIa interface [polypeptide binding]; other site 137722003718 Phospholipid binding site [chemical binding]; other site 137722003719 Subunit I/III interface [polypeptide binding]; other site 137722003720 Subunit III/VIb interface [polypeptide binding]; other site 137722003721 Subunit III/VIa interface; other site 137722003722 Subunit III/Vb interface [polypeptide binding]; other site 137722003723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 137722003724 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 137722003725 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 137722003726 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 137722003727 active site 137722003728 Zn binding site [ion binding]; other site 137722003729 anthranilate synthase component I; Provisional; Region: PRK13573 137722003730 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 137722003731 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 137722003732 SurA N-terminal domain; Region: SurA_N_3; cl07813 137722003733 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 137722003734 CsbD-like; Region: CsbD; pfam05532 137722003735 hypothetical protein; Provisional; Region: PRK02237 137722003736 PAS domain S-box; Region: sensory_box; TIGR00229 137722003737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722003738 putative active site [active] 137722003739 heme pocket [chemical binding]; other site 137722003740 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722003741 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722003742 metal binding site [ion binding]; metal-binding site 137722003743 active site 137722003744 I-site; other site 137722003745 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722003746 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 137722003747 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 137722003748 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722003749 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 137722003750 Walker A/P-loop; other site 137722003751 ATP binding site [chemical binding]; other site 137722003752 Q-loop/lid; other site 137722003753 ABC transporter signature motif; other site 137722003754 Walker B; other site 137722003755 D-loop; other site 137722003756 H-loop/switch region; other site 137722003757 TOBE domain; Region: TOBE_2; pfam08402 137722003758 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 137722003759 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 137722003760 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 137722003761 Walker A/P-loop; other site 137722003762 ATP binding site [chemical binding]; other site 137722003763 Q-loop/lid; other site 137722003764 ABC transporter signature motif; other site 137722003765 Walker B; other site 137722003766 D-loop; other site 137722003767 H-loop/switch region; other site 137722003768 hypothetical protein; Provisional; Region: PRK10279 137722003769 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 137722003770 active site 137722003771 nucleophile elbow; other site 137722003772 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 137722003773 potassium/proton antiporter; Reviewed; Region: PRK05326 137722003774 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 137722003775 Transporter associated domain; Region: CorC_HlyC; smart01091 137722003776 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 137722003777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 137722003778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722003779 dimer interface [polypeptide binding]; other site 137722003780 conserved gate region; other site 137722003781 putative PBP binding loops; other site 137722003782 ABC-ATPase subunit interface; other site 137722003783 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 137722003784 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 137722003785 G1 box; other site 137722003786 putative GEF interaction site [polypeptide binding]; other site 137722003787 GTP/Mg2+ binding site [chemical binding]; other site 137722003788 Switch I region; other site 137722003789 G2 box; other site 137722003790 G3 box; other site 137722003791 Switch II region; other site 137722003792 G4 box; other site 137722003793 G5 box; other site 137722003794 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 137722003795 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 137722003796 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 137722003797 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 137722003798 Surface antigen; Region: Bac_surface_Ag; pfam01103 137722003799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 137722003800 Family of unknown function (DUF490); Region: DUF490; pfam04357 137722003801 Methyltransferase domain; Region: Methyltransf_31; pfam13847 137722003802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722003803 S-adenosylmethionine binding site [chemical binding]; other site 137722003804 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 137722003805 Sel1-like repeats; Region: SEL1; smart00671 137722003806 Sel1 repeat; Region: Sel1; cl02723 137722003807 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 137722003808 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722003809 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722003810 catalytic residue [active] 137722003811 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722003812 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 137722003813 DNA binding residues [nucleotide binding] 137722003814 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 137722003815 OsmC-like protein; Region: OsmC; cl00767 137722003816 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 137722003817 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 137722003818 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 137722003819 homodimer interface [polypeptide binding]; other site 137722003820 substrate-cofactor binding pocket; other site 137722003821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722003822 catalytic residue [active] 137722003823 Helix-turn-helix domain; Region: HTH_18; pfam12833 137722003824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722003825 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 137722003826 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 137722003827 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 137722003828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722003829 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722003830 putative active site [active] 137722003831 heme pocket [chemical binding]; other site 137722003832 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 137722003833 dimer interface [polypeptide binding]; other site 137722003834 phosphorylation site [posttranslational modification] 137722003835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722003836 ATP binding site [chemical binding]; other site 137722003837 Mg2+ binding site [ion binding]; other site 137722003838 G-X-G motif; other site 137722003839 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722003840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722003841 active site 137722003842 phosphorylation site [posttranslational modification] 137722003843 intermolecular recognition site; other site 137722003844 dimerization interface [polypeptide binding]; other site 137722003845 PAS fold; Region: PAS_3; pfam08447 137722003846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722003847 putative active site [active] 137722003848 heme pocket [chemical binding]; other site 137722003849 PAS fold; Region: PAS_3; pfam08447 137722003850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722003851 putative active site [active] 137722003852 heme pocket [chemical binding]; other site 137722003853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722003854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722003855 ATP binding site [chemical binding]; other site 137722003856 Mg2+ binding site [ion binding]; other site 137722003857 G-X-G motif; other site 137722003858 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 137722003859 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 137722003860 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 137722003861 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 137722003862 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 137722003863 Ligand binding site [chemical binding]; other site 137722003864 Electron transfer flavoprotein domain; Region: ETF; pfam01012 137722003865 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 137722003866 active site 137722003867 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 137722003868 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 137722003869 DNA binding residues [nucleotide binding] 137722003870 putative dimer interface [polypeptide binding]; other site 137722003871 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 137722003872 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 137722003873 acyl-activating enzyme (AAE) consensus motif; other site 137722003874 putative AMP binding site [chemical binding]; other site 137722003875 putative active site [active] 137722003876 putative CoA binding site [chemical binding]; other site 137722003877 SCP-2 sterol transfer family; Region: SCP2; pfam02036 137722003878 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 137722003879 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 137722003880 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 137722003881 ligand binding site [chemical binding]; other site 137722003882 Uncharacterized conserved protein [Function unknown]; Region: COG2308 137722003883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 137722003884 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 137722003885 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 137722003886 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 137722003887 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 137722003888 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722003889 HAMP domain; Region: HAMP; pfam00672 137722003890 dimerization interface [polypeptide binding]; other site 137722003891 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722003892 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722003893 dimer interface [polypeptide binding]; other site 137722003894 putative CheW interface [polypeptide binding]; other site 137722003895 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 137722003896 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 137722003897 DctM-like transporters; Region: DctM; pfam06808 137722003898 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 137722003899 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 137722003900 cystathionine beta-lyase; Provisional; Region: PRK09028 137722003901 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 137722003902 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722003903 catalytic residue [active] 137722003904 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 137722003905 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722003906 substrate binding pocket [chemical binding]; other site 137722003907 membrane-bound complex binding site; other site 137722003908 hinge residues; other site 137722003909 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 137722003910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722003911 conserved gate region; other site 137722003912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722003913 putative PBP binding loops; other site 137722003914 dimer interface [polypeptide binding]; other site 137722003915 ABC-ATPase subunit interface; other site 137722003916 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 137722003917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722003918 dimer interface [polypeptide binding]; other site 137722003919 conserved gate region; other site 137722003920 putative PBP binding loops; other site 137722003921 ABC-ATPase subunit interface; other site 137722003922 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 137722003923 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 137722003924 Walker A/P-loop; other site 137722003925 ATP binding site [chemical binding]; other site 137722003926 Q-loop/lid; other site 137722003927 ABC transporter signature motif; other site 137722003928 Walker B; other site 137722003929 D-loop; other site 137722003930 H-loop/switch region; other site 137722003931 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 137722003932 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722003933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722003934 homodimer interface [polypeptide binding]; other site 137722003935 catalytic residue [active] 137722003936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722003937 Coenzyme A binding pocket [chemical binding]; other site 137722003938 putative acetyltransferase; Provisional; Region: PRK03624 137722003939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722003940 Coenzyme A binding pocket [chemical binding]; other site 137722003941 3-mercaptopyruvate sulfurtransferase; Region: PLN02723 137722003942 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 137722003943 active site residue [active] 137722003944 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 137722003945 active site residue [active] 137722003946 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 137722003947 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 137722003948 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 137722003949 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 137722003950 dimer interface [polypeptide binding]; other site 137722003951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722003952 catalytic residue [active] 137722003953 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 137722003954 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 137722003955 dimer interface [polypeptide binding]; other site 137722003956 ADP-ribose binding site [chemical binding]; other site 137722003957 active site 137722003958 nudix motif; other site 137722003959 metal binding site [ion binding]; metal-binding site 137722003960 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 137722003961 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 137722003962 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 137722003963 protein binding site [polypeptide binding]; other site 137722003964 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 137722003965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 137722003966 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 137722003967 active site residue [active] 137722003968 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 137722003969 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 137722003970 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 137722003971 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 137722003972 HIGH motif; other site 137722003973 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 137722003974 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 137722003975 active site 137722003976 KMSKS motif; other site 137722003977 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 137722003978 tRNA binding surface [nucleotide binding]; other site 137722003979 anticodon binding site; other site 137722003980 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 137722003981 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 137722003982 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 137722003983 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 137722003984 active site 137722003985 substrate binding site [chemical binding]; other site 137722003986 cosubstrate binding site; other site 137722003987 catalytic site [active] 137722003988 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 137722003989 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 137722003990 dimerization interface [polypeptide binding]; other site 137722003991 putative ATP binding site [chemical binding]; other site 137722003992 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 137722003993 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 137722003994 Domain of unknown function DUF20; Region: UPF0118; pfam01594 137722003995 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 137722003996 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 137722003997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 137722003998 short chain dehydrogenase; Provisional; Region: PRK08339 137722003999 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 137722004000 putative NAD(P) binding site [chemical binding]; other site 137722004001 putative active site [active] 137722004002 MarR family; Region: MarR_2; pfam12802 137722004003 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722004004 Archaeal ATPase; Region: Arch_ATPase; pfam01637 137722004005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722004006 Walker A motif; other site 137722004007 ATP binding site [chemical binding]; other site 137722004008 Walker B motif; other site 137722004009 arginine finger; other site 137722004010 N-formylglutamate amidohydrolase; Region: FGase; cl01522 137722004011 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722004012 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 137722004013 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 137722004014 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 137722004015 putative metal binding site; other site 137722004016 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722004017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722004018 sequence-specific DNA binding site [nucleotide binding]; other site 137722004019 salt bridge; other site 137722004020 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 137722004021 active site 137722004022 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 137722004023 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 137722004024 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 137722004025 SLBB domain; Region: SLBB; pfam10531 137722004026 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 137722004027 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 137722004028 active site 137722004029 Zn binding site [ion binding]; other site 137722004030 SprA-related family; Region: SprA-related; pfam12118 137722004031 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 137722004032 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 137722004033 putative active site; other site 137722004034 catalytic triad [active] 137722004035 putative dimer interface [polypeptide binding]; other site 137722004036 Transcriptional regulators [Transcription]; Region: MarR; COG1846 137722004037 MarR family; Region: MarR_2; pfam12802 137722004038 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 137722004039 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722004040 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722004041 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 137722004042 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722004043 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722004044 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722004045 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722004046 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722004047 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722004048 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 137722004049 PhoU domain; Region: PhoU; pfam01895 137722004050 PhoU domain; Region: PhoU; pfam01895 137722004051 anthranilate synthase; Provisional; Region: PRK13566 137722004052 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 137722004053 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 137722004054 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 137722004055 glutamine binding [chemical binding]; other site 137722004056 catalytic triad [active] 137722004057 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 137722004058 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 137722004059 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 137722004060 ligand binding site [chemical binding]; other site 137722004061 homodimer interface [polypeptide binding]; other site 137722004062 NAD(P) binding site [chemical binding]; other site 137722004063 trimer interface B [polypeptide binding]; other site 137722004064 trimer interface A [polypeptide binding]; other site 137722004065 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 137722004066 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 137722004067 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 137722004068 Uncharacterized conserved protein [Function unknown]; Region: COG5470 137722004069 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 137722004070 NMT1-like family; Region: NMT1_2; pfam13379 137722004071 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722004072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 137722004073 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722004074 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 137722004075 Walker A/P-loop; other site 137722004076 ATP binding site [chemical binding]; other site 137722004077 Q-loop/lid; other site 137722004078 ABC transporter signature motif; other site 137722004079 Walker B; other site 137722004080 D-loop; other site 137722004081 H-loop/switch region; other site 137722004082 threonine dehydratase; Provisional; Region: PRK07334 137722004083 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 137722004084 tetramer interface [polypeptide binding]; other site 137722004085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722004086 catalytic residue [active] 137722004087 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 137722004088 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 137722004089 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 137722004090 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 137722004091 active site 137722004092 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 137722004093 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 137722004094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722004095 PAS domain; Region: PAS_9; pfam13426 137722004096 putative active site [active] 137722004097 heme pocket [chemical binding]; other site 137722004098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722004099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722004100 dimer interface [polypeptide binding]; other site 137722004101 phosphorylation site [posttranslational modification] 137722004102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722004103 ATP binding site [chemical binding]; other site 137722004104 Mg2+ binding site [ion binding]; other site 137722004105 G-X-G motif; other site 137722004106 Response regulator receiver domain; Region: Response_reg; pfam00072 137722004107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722004108 active site 137722004109 phosphorylation site [posttranslational modification] 137722004110 intermolecular recognition site; other site 137722004111 dimerization interface [polypeptide binding]; other site 137722004112 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 137722004113 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 137722004114 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 137722004115 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722004116 catalytic residue [active] 137722004117 PAS fold; Region: PAS_4; pfam08448 137722004118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722004119 putative active site [active] 137722004120 heme pocket [chemical binding]; other site 137722004121 PAS domain S-box; Region: sensory_box; TIGR00229 137722004122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722004123 putative active site [active] 137722004124 heme pocket [chemical binding]; other site 137722004125 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722004126 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722004127 metal binding site [ion binding]; metal-binding site 137722004128 active site 137722004129 I-site; other site 137722004130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722004131 Response regulator receiver domain; Region: Response_reg; pfam00072 137722004132 active site 137722004133 phosphorylation site [posttranslational modification] 137722004134 intermolecular recognition site; other site 137722004135 dimerization interface [polypeptide binding]; other site 137722004136 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 137722004137 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722004138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722004139 putative active site [active] 137722004140 heme pocket [chemical binding]; other site 137722004141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722004142 dimer interface [polypeptide binding]; other site 137722004143 phosphorylation site [posttranslational modification] 137722004144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722004145 ATP binding site [chemical binding]; other site 137722004146 Mg2+ binding site [ion binding]; other site 137722004147 G-X-G motif; other site 137722004148 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722004149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722004150 active site 137722004151 phosphorylation site [posttranslational modification] 137722004152 intermolecular recognition site; other site 137722004153 dimerization interface [polypeptide binding]; other site 137722004154 Response regulator receiver domain; Region: Response_reg; pfam00072 137722004155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722004156 active site 137722004157 phosphorylation site [posttranslational modification] 137722004158 intermolecular recognition site; other site 137722004159 dimerization interface [polypeptide binding]; other site 137722004160 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 137722004161 putative binding surface; other site 137722004162 active site 137722004163 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722004164 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722004165 substrate binding pocket [chemical binding]; other site 137722004166 membrane-bound complex binding site; other site 137722004167 hinge residues; other site 137722004168 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 137722004169 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 137722004170 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 137722004171 dimer interface [polypeptide binding]; other site 137722004172 N-terminal domain interface [polypeptide binding]; other site 137722004173 putative substrate binding pocket (H-site) [chemical binding]; other site 137722004174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 137722004175 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 137722004176 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 137722004177 Uncharacterized conserved protein [Function unknown]; Region: COG2014 137722004178 Domain of unknown function (DUF364); Region: DUF364; pfam04016 137722004179 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 137722004180 CPxP motif; other site 137722004181 short chain dehydrogenase; Provisional; Region: PRK06181 137722004182 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 137722004183 putative NAD(P) binding site [chemical binding]; other site 137722004184 active site 137722004185 putative chaperone; Provisional; Region: PRK11678 137722004186 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 137722004187 nucleotide binding site [chemical binding]; other site 137722004188 putative NEF/HSP70 interaction site [polypeptide binding]; other site 137722004189 SBD interface [polypeptide binding]; other site 137722004190 Domain of unknown function DUF59; Region: DUF59; pfam01883 137722004191 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 137722004192 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 137722004193 HflK protein; Region: hflK; TIGR01933 137722004194 HflC protein; Region: hflC; TIGR01932 137722004195 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 137722004196 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 137722004197 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 137722004198 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 137722004199 protein binding site [polypeptide binding]; other site 137722004200 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 137722004201 protein binding site [polypeptide binding]; other site 137722004202 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722004203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722004204 active site 137722004205 phosphorylation site [posttranslational modification] 137722004206 intermolecular recognition site; other site 137722004207 dimerization interface [polypeptide binding]; other site 137722004208 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722004209 DNA binding residues [nucleotide binding] 137722004210 dimerization interface [polypeptide binding]; other site 137722004211 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 137722004212 HAMP domain; Region: HAMP; pfam00672 137722004213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722004214 dimer interface [polypeptide binding]; other site 137722004215 phosphorylation site [posttranslational modification] 137722004216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722004217 ATP binding site [chemical binding]; other site 137722004218 Mg2+ binding site [ion binding]; other site 137722004219 G-X-G motif; other site 137722004220 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722004221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722004222 active site 137722004223 phosphorylation site [posttranslational modification] 137722004224 intermolecular recognition site; other site 137722004225 dimerization interface [polypeptide binding]; other site 137722004226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722004227 DNA binding site [nucleotide binding] 137722004228 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722004229 MarR family; Region: MarR_2; pfam12802 137722004230 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 137722004231 diiron binding motif [ion binding]; other site 137722004232 Uncharacterized conserved protein [Function unknown]; Region: COG1633 137722004233 CCC1-related family of proteins; Region: CCC1_like; cl00278 137722004234 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 137722004235 triosephosphate isomerase; Provisional; Region: PRK14565 137722004236 substrate binding site [chemical binding]; other site 137722004237 dimer interface [polypeptide binding]; other site 137722004238 catalytic triad [active] 137722004239 Preprotein translocase SecG subunit; Region: SecG; cl09123 137722004240 CTP synthetase; Validated; Region: pyrG; PRK05380 137722004241 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 137722004242 Catalytic site [active] 137722004243 active site 137722004244 UTP binding site [chemical binding]; other site 137722004245 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 137722004246 active site 137722004247 putative oxyanion hole; other site 137722004248 catalytic triad [active] 137722004249 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 137722004250 active site 137722004251 catalytic triad [active] 137722004252 oxyanion hole [active] 137722004253 Autotransporter beta-domain; Region: Autotransporter; cl17461 137722004254 Dienelactone hydrolase family; Region: DLH; pfam01738 137722004255 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722004256 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722004257 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722004258 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722004259 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 137722004260 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 137722004261 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 137722004262 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722004263 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722004264 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 137722004265 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 137722004266 Walker A/P-loop; other site 137722004267 ATP binding site [chemical binding]; other site 137722004268 Q-loop/lid; other site 137722004269 ABC transporter signature motif; other site 137722004270 Walker B; other site 137722004271 D-loop; other site 137722004272 H-loop/switch region; other site 137722004273 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 137722004274 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 137722004275 FtsX-like permease family; Region: FtsX; pfam02687 137722004276 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 137722004277 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 137722004278 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722004279 active site 137722004280 Int/Topo IB signature motif; other site 137722004281 DNA binding site [nucleotide binding] 137722004282 multiple promoter invertase; Provisional; Region: mpi; PRK13413 137722004283 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 137722004284 catalytic residues [active] 137722004285 catalytic nucleophile [active] 137722004286 Presynaptic Site I dimer interface [polypeptide binding]; other site 137722004287 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 137722004288 Synaptic Flat tetramer interface [polypeptide binding]; other site 137722004289 Synaptic Site I dimer interface [polypeptide binding]; other site 137722004290 DNA binding site [nucleotide binding] 137722004291 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 137722004292 DNA-binding interface [nucleotide binding]; DNA binding site 137722004293 MobA/MobL family; Region: MobA_MobL; pfam03389 137722004294 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 137722004295 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 137722004296 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 137722004297 active site 137722004298 (T/H)XGH motif; other site 137722004299 DNA gyrase subunit A; Validated; Region: PRK05560 137722004300 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 137722004301 CAP-like domain; other site 137722004302 active site 137722004303 primary dimer interface [polypeptide binding]; other site 137722004304 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 137722004305 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 137722004306 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 137722004307 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 137722004308 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 137722004309 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 137722004310 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 137722004311 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 137722004312 cation binding site [ion binding]; other site 137722004313 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 137722004314 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722004315 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722004316 catalytic residue [active] 137722004317 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 137722004318 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 137722004319 dimer interface [polypeptide binding]; other site 137722004320 active site 137722004321 catalytic residue [active] 137722004322 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 137722004323 SmpB-tmRNA interface; other site 137722004324 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 137722004325 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 137722004326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722004327 S-adenosylmethionine binding site [chemical binding]; other site 137722004328 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 137722004329 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 137722004330 active site 137722004331 catalytic tetrad [active] 137722004332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722004333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722004334 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 137722004335 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 137722004336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722004337 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 137722004338 substrate binding site [chemical binding]; other site 137722004339 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 137722004340 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 137722004341 dimer interface [polypeptide binding]; other site 137722004342 allosteric magnesium binding site [ion binding]; other site 137722004343 active site 137722004344 aspartate-rich active site metal binding site; other site 137722004345 Schiff base residues; other site 137722004346 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 137722004347 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 137722004348 putative active site [active] 137722004349 putative metal binding site [ion binding]; other site 137722004350 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 137722004351 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 137722004352 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 137722004353 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 137722004354 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722004355 substrate binding site [chemical binding]; other site 137722004356 oxyanion hole (OAH) forming residues; other site 137722004357 trimer interface [polypeptide binding]; other site 137722004358 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 137722004359 Transcriptional regulators [Transcription]; Region: MarR; COG1846 137722004360 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 137722004361 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 137722004362 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 137722004363 putative ligand binding site [chemical binding]; other site 137722004364 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722004365 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722004366 TM-ABC transporter signature motif; other site 137722004367 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722004368 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 137722004369 TM-ABC transporter signature motif; other site 137722004370 Phasin protein; Region: Phasin_2; cl11491 137722004371 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 137722004372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722004373 Walker B; other site 137722004374 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722004375 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722004376 catalytic residue [active] 137722004377 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 137722004378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722004379 TPR motif; other site 137722004380 binding surface 137722004381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 137722004382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722004383 S-adenosylmethionine binding site [chemical binding]; other site 137722004384 short chain dehydrogenase; Provisional; Region: PRK06701 137722004385 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 137722004386 NAD binding site [chemical binding]; other site 137722004387 metal binding site [ion binding]; metal-binding site 137722004388 active site 137722004389 HAMP domain; Region: HAMP; pfam00672 137722004390 dimerization interface [polypeptide binding]; other site 137722004391 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722004392 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722004393 dimer interface [polypeptide binding]; other site 137722004394 putative CheW interface [polypeptide binding]; other site 137722004395 Transposase domain (DUF772); Region: DUF772; pfam05598 137722004396 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722004397 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 137722004398 RNA polymerase sigma factor; Provisional; Region: PRK12547 137722004399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722004400 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722004401 DNA binding residues [nucleotide binding] 137722004402 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 137722004403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722004404 Coenzyme A binding pocket [chemical binding]; other site 137722004405 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 137722004406 homodimer interface [polypeptide binding]; other site 137722004407 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 137722004408 active site pocket [active] 137722004409 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 137722004410 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 137722004411 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 137722004412 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 137722004413 G1 box; other site 137722004414 putative GEF interaction site [polypeptide binding]; other site 137722004415 GTP/Mg2+ binding site [chemical binding]; other site 137722004416 Switch I region; other site 137722004417 G2 box; other site 137722004418 G3 box; other site 137722004419 Switch II region; other site 137722004420 G4 box; other site 137722004421 G5 box; other site 137722004422 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 137722004423 PAS fold; Region: PAS_4; pfam08448 137722004424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722004425 putative active site [active] 137722004426 heme pocket [chemical binding]; other site 137722004427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722004428 dimer interface [polypeptide binding]; other site 137722004429 phosphorylation site [posttranslational modification] 137722004430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722004431 ATP binding site [chemical binding]; other site 137722004432 Mg2+ binding site [ion binding]; other site 137722004433 G-X-G motif; other site 137722004434 Response regulator receiver domain; Region: Response_reg; pfam00072 137722004435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722004436 active site 137722004437 phosphorylation site [posttranslational modification] 137722004438 intermolecular recognition site; other site 137722004439 dimerization interface [polypeptide binding]; other site 137722004440 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 137722004441 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 137722004442 Transglutaminase/protease-like homologues; Region: TGc; smart00460 137722004443 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 137722004444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 137722004445 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 137722004446 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722004447 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722004448 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722004449 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 137722004450 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 137722004451 active site 137722004452 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 137722004453 Autotransporter beta-domain; Region: Autotransporter; pfam03797 137722004454 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 137722004455 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 137722004456 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 137722004457 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 137722004458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 137722004459 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 137722004460 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 137722004461 active site 137722004462 catalytic residues [active] 137722004463 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 137722004464 Catalytic domain of Protein Kinases; Region: PKc; cd00180 137722004465 active site 137722004466 ATP binding site [chemical binding]; other site 137722004467 substrate binding site [chemical binding]; other site 137722004468 activation loop (A-loop); other site 137722004469 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 137722004470 active site 137722004471 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 137722004472 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 137722004473 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 137722004474 Tetratricopeptide repeat; Region: TPR_12; pfam13424 137722004475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722004476 binding surface 137722004477 TPR motif; other site 137722004478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722004479 binding surface 137722004480 TPR motif; other site 137722004481 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 137722004482 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 137722004483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722004484 active site 137722004485 motif I; other site 137722004486 motif II; other site 137722004487 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 137722004488 OstA-like protein; Region: OstA; cl00844 137722004489 Organic solvent tolerance protein; Region: OstA_C; pfam04453 137722004490 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 137722004491 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 137722004492 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 137722004493 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 137722004494 dimer interface [polypeptide binding]; other site 137722004495 active site 137722004496 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 137722004497 catalytic residues [active] 137722004498 substrate binding site [chemical binding]; other site 137722004499 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 137722004500 Cupin domain; Region: Cupin_2; pfam07883 137722004501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722004502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722004503 putative substrate translocation pore; other site 137722004504 seryl-tRNA synthetase; Provisional; Region: PRK05431 137722004505 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 137722004506 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 137722004507 dimer interface [polypeptide binding]; other site 137722004508 active site 137722004509 motif 1; other site 137722004510 motif 2; other site 137722004511 motif 3; other site 137722004512 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 137722004513 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 137722004514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722004515 S-adenosylmethionine binding site [chemical binding]; other site 137722004516 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 137722004517 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 137722004518 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 137722004519 Peptidase family M23; Region: Peptidase_M23; pfam01551 137722004520 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 137722004521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722004522 Walker A motif; other site 137722004523 ATP binding site [chemical binding]; other site 137722004524 Walker B motif; other site 137722004525 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 137722004526 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 137722004527 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 137722004528 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 137722004529 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 137722004530 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 137722004531 Protein export membrane protein; Region: SecD_SecF; pfam02355 137722004532 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 137722004533 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 137722004534 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 137722004535 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 137722004536 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 137722004537 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 137722004538 active site lid residues [active] 137722004539 substrate binding pocket [chemical binding]; other site 137722004540 catalytic residues [active] 137722004541 substrate-Mg2+ binding site; other site 137722004542 aspartate-rich region 1; other site 137722004543 aspartate-rich region 2; other site 137722004544 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 137722004545 active site lid residues [active] 137722004546 substrate binding pocket [chemical binding]; other site 137722004547 catalytic residues [active] 137722004548 substrate-Mg2+ binding site; other site 137722004549 aspartate-rich region 1; other site 137722004550 aspartate-rich region 2; other site 137722004551 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 137722004552 substrate binding pocket [chemical binding]; other site 137722004553 substrate-Mg2+ binding site; other site 137722004554 aspartate-rich region 1; other site 137722004555 aspartate-rich region 2; other site 137722004556 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 137722004557 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 137722004558 active site 137722004559 metal binding site [ion binding]; metal-binding site 137722004560 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 137722004561 Glucose inhibited division protein A; Region: GIDA; pfam01134 137722004562 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722004563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722004564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722004565 dimerization interface [polypeptide binding]; other site 137722004566 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 137722004567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722004568 putative substrate translocation pore; other site 137722004569 Methyltransferase domain; Region: Methyltransf_31; pfam13847 137722004570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722004571 S-adenosylmethionine binding site [chemical binding]; other site 137722004572 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 137722004573 active site 137722004574 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 137722004575 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 137722004576 cofactor binding site; other site 137722004577 DNA binding site [nucleotide binding] 137722004578 substrate interaction site [chemical binding]; other site 137722004579 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 137722004580 additional DNA contacts [nucleotide binding]; other site 137722004581 mismatch recognition site; other site 137722004582 active site 137722004583 zinc binding site [ion binding]; other site 137722004584 DNA intercalation site [nucleotide binding]; other site 137722004585 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722004586 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722004587 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 137722004588 Int/Topo IB signature motif; other site 137722004589 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 137722004590 metal ion-dependent adhesion site (MIDAS); other site 137722004591 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 137722004592 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 137722004593 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 137722004594 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 137722004595 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 137722004596 Protein of unknown function DUF58; Region: DUF58; pfam01882 137722004597 MoxR-like ATPases [General function prediction only]; Region: COG0714 137722004598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722004599 Walker A motif; other site 137722004600 ATP binding site [chemical binding]; other site 137722004601 Walker B motif; other site 137722004602 arginine finger; other site 137722004603 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 137722004604 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 137722004605 putative active site [active] 137722004606 putative CoA binding site [chemical binding]; other site 137722004607 nudix motif; other site 137722004608 metal binding site [ion binding]; metal-binding site 137722004609 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 137722004610 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 137722004611 active site 137722004612 NTP binding site [chemical binding]; other site 137722004613 metal binding triad [ion binding]; metal-binding site 137722004614 short chain dehydrogenase; Provisional; Region: PRK07478 137722004615 classical (c) SDRs; Region: SDR_c; cd05233 137722004616 NAD(P) binding site [chemical binding]; other site 137722004617 active site 137722004618 exopolyphosphatase; Region: exo_poly_only; TIGR03706 137722004619 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 137722004620 polyphosphate kinase; Provisional; Region: PRK05443 137722004621 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 137722004622 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 137722004623 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 137722004624 putative domain interface [polypeptide binding]; other site 137722004625 putative active site [active] 137722004626 catalytic site [active] 137722004627 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 137722004628 putative domain interface [polypeptide binding]; other site 137722004629 putative active site [active] 137722004630 catalytic site [active] 137722004631 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 137722004632 catalytic core [active] 137722004633 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 137722004634 putative active site [active] 137722004635 putative triphosphate binding site [ion binding]; other site 137722004636 putative metal binding residues [ion binding]; other site 137722004637 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 137722004638 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 137722004639 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 137722004640 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 137722004641 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 137722004642 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 137722004643 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 137722004644 dimer interface [polypeptide binding]; other site 137722004645 ssDNA binding site [nucleotide binding]; other site 137722004646 tetramer (dimer of dimers) interface [polypeptide binding]; other site 137722004647 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722004648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722004649 active site 137722004650 phosphorylation site [posttranslational modification] 137722004651 intermolecular recognition site; other site 137722004652 dimerization interface [polypeptide binding]; other site 137722004653 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 137722004654 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 137722004655 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 137722004656 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 137722004657 active site 137722004658 Zn binding site [ion binding]; other site 137722004659 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722004660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722004661 Walker A/P-loop; other site 137722004662 ATP binding site [chemical binding]; other site 137722004663 Q-loop/lid; other site 137722004664 ABC transporter signature motif; other site 137722004665 Walker B; other site 137722004666 D-loop; other site 137722004667 H-loop/switch region; other site 137722004668 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722004669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722004670 dimer interface [polypeptide binding]; other site 137722004671 conserved gate region; other site 137722004672 ABC-ATPase subunit interface; other site 137722004673 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 137722004674 NMT1/THI5 like; Region: NMT1; pfam09084 137722004675 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722004676 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722004677 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 137722004678 Ligand Binding Site [chemical binding]; other site 137722004679 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 137722004680 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 137722004681 active site 137722004682 putative lithium-binding site [ion binding]; other site 137722004683 substrate binding site [chemical binding]; other site 137722004684 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 137722004685 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 137722004686 HflX GTPase family; Region: HflX; cd01878 137722004687 G1 box; other site 137722004688 GTP/Mg2+ binding site [chemical binding]; other site 137722004689 Switch I region; other site 137722004690 G2 box; other site 137722004691 G3 box; other site 137722004692 Switch II region; other site 137722004693 G4 box; other site 137722004694 G5 box; other site 137722004695 bacterial Hfq-like; Region: Hfq; cd01716 137722004696 hexamer interface [polypeptide binding]; other site 137722004697 Sm1 motif; other site 137722004698 RNA binding site [nucleotide binding]; other site 137722004699 Sm2 motif; other site 137722004700 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 137722004701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722004702 motif II; other site 137722004703 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 137722004704 putative active site [active] 137722004705 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 137722004706 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 137722004707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722004708 active site 137722004709 phosphorylation site [posttranslational modification] 137722004710 intermolecular recognition site; other site 137722004711 dimerization interface [polypeptide binding]; other site 137722004712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722004713 Walker A motif; other site 137722004714 ATP binding site [chemical binding]; other site 137722004715 Walker B motif; other site 137722004716 arginine finger; other site 137722004717 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722004718 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 137722004719 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722004720 dimerization interface [polypeptide binding]; other site 137722004721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722004722 dimer interface [polypeptide binding]; other site 137722004723 phosphorylation site [posttranslational modification] 137722004724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722004725 ATP binding site [chemical binding]; other site 137722004726 Mg2+ binding site [ion binding]; other site 137722004727 G-X-G motif; other site 137722004728 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 137722004729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722004730 active site 137722004731 phosphorylation site [posttranslational modification] 137722004732 intermolecular recognition site; other site 137722004733 dimerization interface [polypeptide binding]; other site 137722004734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722004735 Walker A motif; other site 137722004736 ATP binding site [chemical binding]; other site 137722004737 Walker B motif; other site 137722004738 arginine finger; other site 137722004739 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 137722004740 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 137722004741 PAS domain; Region: PAS; smart00091 137722004742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722004743 dimer interface [polypeptide binding]; other site 137722004744 phosphorylation site [posttranslational modification] 137722004745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722004746 ATP binding site [chemical binding]; other site 137722004747 Mg2+ binding site [ion binding]; other site 137722004748 G-X-G motif; other site 137722004749 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 137722004750 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 137722004751 FMN binding site [chemical binding]; other site 137722004752 active site 137722004753 catalytic residues [active] 137722004754 substrate binding site [chemical binding]; other site 137722004755 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 137722004756 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 137722004757 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 137722004758 substrate binding site; other site 137722004759 dimer interface; other site 137722004760 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 137722004761 homotrimer interaction site [polypeptide binding]; other site 137722004762 zinc binding site [ion binding]; other site 137722004763 CDP-binding sites; other site 137722004764 Competence-damaged protein; Region: CinA; pfam02464 137722004765 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 137722004766 active site 1 [active] 137722004767 dimer interface [polypeptide binding]; other site 137722004768 hexamer interface [polypeptide binding]; other site 137722004769 active site 2 [active] 137722004770 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 137722004771 putative coenzyme Q binding site [chemical binding]; other site 137722004772 lipoyl synthase; Provisional; Region: PRK05481 137722004773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722004774 FeS/SAM binding site; other site 137722004775 Domain of unknown function DUF29; Region: DUF29; pfam01724 137722004776 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 137722004777 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 137722004778 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 137722004779 Chorismate mutase type II; Region: CM_2; smart00830 137722004780 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 137722004781 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 137722004782 E3 interaction surface; other site 137722004783 lipoyl attachment site [posttranslational modification]; other site 137722004784 e3 binding domain; Region: E3_binding; pfam02817 137722004785 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 137722004786 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 137722004787 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 137722004788 E3 interaction surface; other site 137722004789 lipoyl attachment site [posttranslational modification]; other site 137722004790 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 137722004791 alpha subunit interface [polypeptide binding]; other site 137722004792 TPP binding site [chemical binding]; other site 137722004793 heterodimer interface [polypeptide binding]; other site 137722004794 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 137722004795 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 137722004796 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 137722004797 tetramer interface [polypeptide binding]; other site 137722004798 TPP-binding site [chemical binding]; other site 137722004799 heterodimer interface [polypeptide binding]; other site 137722004800 phosphorylation loop region [posttranslational modification] 137722004801 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 137722004802 Septum formation initiator; Region: DivIC; pfam04977 137722004803 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 137722004804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722004805 Walker A/P-loop; other site 137722004806 ATP binding site [chemical binding]; other site 137722004807 Q-loop/lid; other site 137722004808 ABC transporter signature motif; other site 137722004809 Walker B; other site 137722004810 D-loop; other site 137722004811 H-loop/switch region; other site 137722004812 TOBE domain; Region: TOBE; cl01440 137722004813 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 137722004814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722004815 dimer interface [polypeptide binding]; other site 137722004816 conserved gate region; other site 137722004817 putative PBP binding loops; other site 137722004818 ABC-ATPase subunit interface; other site 137722004819 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 137722004820 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 137722004821 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 137722004822 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 137722004823 substrate binding site [chemical binding]; other site 137722004824 hexamer interface [polypeptide binding]; other site 137722004825 metal binding site [ion binding]; metal-binding site 137722004826 Predicted membrane protein [Function unknown]; Region: COG2261 137722004827 two-component response regulator; Provisional; Region: PRK09191 137722004828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 137722004829 DNA binding residues [nucleotide binding] 137722004830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722004831 active site 137722004832 phosphorylation site [posttranslational modification] 137722004833 intermolecular recognition site; other site 137722004834 dimerization interface [polypeptide binding]; other site 137722004835 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 137722004836 Catalytic site; other site 137722004837 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 137722004838 Uncharacterized conserved protein [Function unknown]; Region: COG2135 137722004839 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 137722004840 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 137722004841 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 137722004842 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722004843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722004844 Coenzyme A binding pocket [chemical binding]; other site 137722004845 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 137722004846 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 137722004847 active site 137722004848 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 137722004849 dinuclear metal binding motif [ion binding]; other site 137722004850 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 137722004851 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 137722004852 putative active site [active] 137722004853 putative substrate binding site [chemical binding]; other site 137722004854 ATP binding site [chemical binding]; other site 137722004855 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 137722004856 RNA/DNA hybrid binding site [nucleotide binding]; other site 137722004857 active site 137722004858 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 137722004859 catalytic triad [active] 137722004860 dimer interface [polypeptide binding]; other site 137722004861 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 137722004862 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 137722004863 PhnA protein; Region: PhnA; pfam03831 137722004864 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 137722004865 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 137722004866 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 137722004867 DsbD alpha interface [polypeptide binding]; other site 137722004868 catalytic residues [active] 137722004869 hypothetical protein; Validated; Region: PRK00228 137722004870 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 137722004871 MoaE homodimer interface [polypeptide binding]; other site 137722004872 MoaD interaction [polypeptide binding]; other site 137722004873 active site residues [active] 137722004874 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 137722004875 MoaE interaction surface [polypeptide binding]; other site 137722004876 MoeB interaction surface [polypeptide binding]; other site 137722004877 thiocarboxylated glycine; other site 137722004878 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 137722004879 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 137722004880 dimer interface [polypeptide binding]; other site 137722004881 putative functional site; other site 137722004882 putative MPT binding site; other site 137722004883 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 137722004884 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722004885 motif II; other site 137722004886 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 137722004887 Walker A motif; other site 137722004888 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 137722004889 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 137722004890 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 137722004891 GIY-YIG motif/motif A; other site 137722004892 active site 137722004893 catalytic site [active] 137722004894 putative DNA binding site [nucleotide binding]; other site 137722004895 metal binding site [ion binding]; metal-binding site 137722004896 UvrB/uvrC motif; Region: UVR; pfam02151 137722004897 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 137722004898 short chain dehydrogenase; Provisional; Region: PRK09134 137722004899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722004900 NAD(P) binding site [chemical binding]; other site 137722004901 active site 137722004902 Protein of unknown function (DUF983); Region: DUF983; cl02211 137722004903 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 137722004904 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 137722004905 zinc binding site [ion binding]; other site 137722004906 putative ligand binding site [chemical binding]; other site 137722004907 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722004908 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 137722004909 TM-ABC transporter signature motif; other site 137722004910 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 137722004911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722004912 Walker A/P-loop; other site 137722004913 ATP binding site [chemical binding]; other site 137722004914 Q-loop/lid; other site 137722004915 ABC transporter signature motif; other site 137722004916 Walker B; other site 137722004917 D-loop; other site 137722004918 H-loop/switch region; other site 137722004919 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 137722004920 TrkA-N domain; Region: TrkA_N; pfam02254 137722004921 Iron permease FTR1 family; Region: FTR1; cl00475 137722004922 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 137722004923 Uncharacterized conserved protein [Function unknown]; Region: COG3791 137722004924 Uncharacterized conserved protein [Function unknown]; Region: COG3791 137722004925 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 137722004926 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 137722004927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722004928 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 137722004929 dimerization interface [polypeptide binding]; other site 137722004930 substrate binding pocket [chemical binding]; other site 137722004931 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 137722004932 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 137722004933 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 137722004934 dihydroorotase; Validated; Region: PRK09059 137722004935 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 137722004936 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 137722004937 active site 137722004938 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 137722004939 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 137722004940 intracellular protease, PfpI family; Region: PfpI; TIGR01382 137722004941 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 137722004942 conserved cys residue [active] 137722004943 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 137722004944 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 137722004945 acyl-activating enzyme (AAE) consensus motif; other site 137722004946 putative AMP binding site [chemical binding]; other site 137722004947 putative active site [active] 137722004948 putative CoA binding site [chemical binding]; other site 137722004949 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 137722004950 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 137722004951 IHF - DNA interface [nucleotide binding]; other site 137722004952 IHF dimer interface [polypeptide binding]; other site 137722004953 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 137722004954 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 137722004955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722004956 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 137722004957 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722004958 DNA binding residues [nucleotide binding] 137722004959 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 137722004960 heme-binding site [chemical binding]; other site 137722004961 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722004962 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722004963 dimer interface [polypeptide binding]; other site 137722004964 putative CheW interface [polypeptide binding]; other site 137722004965 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 137722004966 Coenzyme A binding pocket [chemical binding]; other site 137722004967 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 137722004968 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 137722004969 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 137722004970 Sel1-like repeats; Region: SEL1; smart00671 137722004971 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 137722004972 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722004973 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722004974 catalytic residue [active] 137722004975 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 137722004976 excinuclease ABC subunit B; Provisional; Region: PRK05298 137722004977 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 137722004978 ATP-binding site [chemical binding]; other site 137722004979 ATP binding site [chemical binding]; other site 137722004980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722004981 nucleotide binding region [chemical binding]; other site 137722004982 ATP-binding site [chemical binding]; other site 137722004983 Ultra-violet resistance protein B; Region: UvrB; pfam12344 137722004984 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 137722004985 GAF domain; Region: GAF_3; pfam13492 137722004986 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722004987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722004988 metal binding site [ion binding]; metal-binding site 137722004989 active site 137722004990 I-site; other site 137722004991 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 137722004992 putative active site [active] 137722004993 putative substrate binding site [chemical binding]; other site 137722004994 ATP binding site [chemical binding]; other site 137722004995 Phosphotransferase enzyme family; Region: APH; pfam01636 137722004996 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 137722004997 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 137722004998 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 137722004999 active site 137722005000 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 137722005001 tetramer interface [polypeptide binding]; other site 137722005002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722005003 catalytic residue [active] 137722005004 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 137722005005 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 137722005006 tetramer interface [polypeptide binding]; other site 137722005007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722005008 catalytic residue [active] 137722005009 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 137722005010 lipoyl attachment site [posttranslational modification]; other site 137722005011 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 137722005012 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 137722005013 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 137722005014 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 137722005015 cobyric acid synthase; Provisional; Region: PRK00784 137722005016 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 137722005017 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 137722005018 catalytic triad [active] 137722005019 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 137722005020 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 137722005021 homodimer interface [polypeptide binding]; other site 137722005022 Walker A motif; other site 137722005023 ATP binding site [chemical binding]; other site 137722005024 hydroxycobalamin binding site [chemical binding]; other site 137722005025 Walker B motif; other site 137722005026 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 137722005027 homotrimer interface [polypeptide binding]; other site 137722005028 Walker A motif; other site 137722005029 GTP binding site [chemical binding]; other site 137722005030 Walker B motif; other site 137722005031 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 137722005032 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 137722005033 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 137722005034 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 137722005035 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 137722005036 metal-binding site [ion binding] 137722005037 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 137722005038 NodB motif; other site 137722005039 putative active site [active] 137722005040 putative catalytic site [active] 137722005041 Zn binding site [ion binding]; other site 137722005042 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 137722005043 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 137722005044 glutamine binding [chemical binding]; other site 137722005045 catalytic triad [active] 137722005046 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 137722005047 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 137722005048 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 137722005049 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 137722005050 active site 137722005051 ribulose/triose binding site [chemical binding]; other site 137722005052 phosphate binding site [ion binding]; other site 137722005053 substrate (anthranilate) binding pocket [chemical binding]; other site 137722005054 product (indole) binding pocket [chemical binding]; other site 137722005055 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 137722005056 Coenzyme A binding pocket [chemical binding]; other site 137722005057 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 137722005058 trimer interface [polypeptide binding]; other site 137722005059 dimer interface [polypeptide binding]; other site 137722005060 putative active site [active] 137722005061 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 137722005062 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 137722005063 dimer interface [polypeptide binding]; other site 137722005064 putative functional site; other site 137722005065 putative MPT binding site; other site 137722005066 LexA repressor; Validated; Region: PRK00215 137722005067 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 137722005068 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 137722005069 Catalytic site [active] 137722005070 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 137722005071 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 137722005072 Competence protein; Region: Competence; pfam03772 137722005073 The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; Region: Luminal_IRE1_like; cl14874 137722005074 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 137722005075 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 137722005076 active site 137722005077 HIGH motif; other site 137722005078 nucleotide binding site [chemical binding]; other site 137722005079 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 137722005080 active site 137722005081 KMSKS motif; other site 137722005082 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 137722005083 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 137722005084 dimer interface [polypeptide binding]; other site 137722005085 active site 137722005086 citrylCoA binding site [chemical binding]; other site 137722005087 NADH binding [chemical binding]; other site 137722005088 cationic pore residues; other site 137722005089 oxalacetate/citrate binding site [chemical binding]; other site 137722005090 coenzyme A binding site [chemical binding]; other site 137722005091 catalytic triad [active] 137722005092 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 137722005093 active site residue [active] 137722005094 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 137722005095 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 137722005096 conserved cys residue [active] 137722005097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722005098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722005099 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 137722005100 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 137722005101 dimer interface [polypeptide binding]; other site 137722005102 active site 137722005103 metal binding site [ion binding]; metal-binding site 137722005104 glutathione binding site [chemical binding]; other site 137722005105 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 137722005106 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 137722005107 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 137722005108 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 137722005109 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 137722005110 active site 137722005111 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 137722005112 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 137722005113 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 137722005114 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 137722005115 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 137722005116 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 137722005117 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 137722005118 Surface antigen; Region: Bac_surface_Ag; pfam01103 137722005119 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 137722005120 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 137722005121 active site 137722005122 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 137722005123 protein binding site [polypeptide binding]; other site 137722005124 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 137722005125 putative substrate binding region [chemical binding]; other site 137722005126 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 137722005127 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 137722005128 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 137722005129 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 137722005130 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 137722005131 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 137722005132 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 137722005133 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 137722005134 catalytic residue [active] 137722005135 putative FPP diphosphate binding site; other site 137722005136 putative FPP binding hydrophobic cleft; other site 137722005137 dimer interface [polypeptide binding]; other site 137722005138 putative IPP diphosphate binding site; other site 137722005139 ribosome recycling factor; Reviewed; Region: frr; PRK00083 137722005140 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 137722005141 hinge region; other site 137722005142 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 137722005143 putative nucleotide binding site [chemical binding]; other site 137722005144 uridine monophosphate binding site [chemical binding]; other site 137722005145 homohexameric interface [polypeptide binding]; other site 137722005146 elongation factor Ts; Provisional; Region: tsf; PRK09377 137722005147 UBA/TS-N domain; Region: UBA; pfam00627 137722005148 Elongation factor TS; Region: EF_TS; pfam00889 137722005149 Elongation factor TS; Region: EF_TS; pfam00889 137722005150 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 137722005151 rRNA interaction site [nucleotide binding]; other site 137722005152 S8 interaction site; other site 137722005153 putative laminin-1 binding site; other site 137722005154 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 137722005155 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 137722005156 dimer interface [polypeptide binding]; other site 137722005157 anticodon binding site; other site 137722005158 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 137722005159 homodimer interface [polypeptide binding]; other site 137722005160 motif 1; other site 137722005161 active site 137722005162 motif 2; other site 137722005163 GAD domain; Region: GAD; pfam02938 137722005164 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 137722005165 active site 137722005166 motif 3; other site 137722005167 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 137722005168 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 137722005169 catalytic site [active] 137722005170 putative active site [active] 137722005171 putative substrate binding site [chemical binding]; other site 137722005172 HRDC domain; Region: HRDC; pfam00570 137722005173 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 137722005174 short chain dehydrogenase; Provisional; Region: PRK07024 137722005175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722005176 NAD(P) binding site [chemical binding]; other site 137722005177 active site 137722005178 hypothetical protein; Provisional; Region: PRK11820 137722005179 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 137722005180 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 137722005181 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 137722005182 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 137722005183 catalytic site [active] 137722005184 G-X2-G-X-G-K; other site 137722005185 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 137722005186 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 137722005187 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722005188 catalytic residue [active] 137722005189 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 137722005190 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722005191 AsnC family; Region: AsnC_trans_reg; pfam01037 137722005192 helicase 45; Provisional; Region: PTZ00424 137722005193 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 137722005194 ATP binding site [chemical binding]; other site 137722005195 Mg++ binding site [ion binding]; other site 137722005196 motif III; other site 137722005197 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722005198 nucleotide binding region [chemical binding]; other site 137722005199 ATP-binding site [chemical binding]; other site 137722005200 Isochorismatase family; Region: Isochorismatase; pfam00857 137722005201 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 137722005202 catalytic triad [active] 137722005203 dimer interface [polypeptide binding]; other site 137722005204 conserved cis-peptide bond; other site 137722005205 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 137722005206 TAP-like protein; Region: Abhydrolase_4; pfam08386 137722005207 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 137722005208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722005209 Mg2+ binding site [ion binding]; other site 137722005210 G-X-G motif; other site 137722005211 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 137722005212 anchoring element; other site 137722005213 dimer interface [polypeptide binding]; other site 137722005214 ATP binding site [chemical binding]; other site 137722005215 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 137722005216 active site 137722005217 putative metal-binding site [ion binding]; other site 137722005218 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 137722005219 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 137722005220 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 137722005221 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 137722005222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722005223 substrate binding pocket [chemical binding]; other site 137722005224 membrane-bound complex binding site; other site 137722005225 hinge residues; other site 137722005226 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722005227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722005228 dimer interface [polypeptide binding]; other site 137722005229 conserved gate region; other site 137722005230 putative PBP binding loops; other site 137722005231 ABC-ATPase subunit interface; other site 137722005232 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722005233 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722005234 Walker A/P-loop; other site 137722005235 ATP binding site [chemical binding]; other site 137722005236 Q-loop/lid; other site 137722005237 ABC transporter signature motif; other site 137722005238 Walker B; other site 137722005239 D-loop; other site 137722005240 H-loop/switch region; other site 137722005241 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 137722005242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722005243 Walker A motif; other site 137722005244 ATP binding site [chemical binding]; other site 137722005245 Walker B motif; other site 137722005246 arginine finger; other site 137722005247 Peptidase family M41; Region: Peptidase_M41; pfam01434 137722005248 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 137722005249 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722005250 substrate binding pocket [chemical binding]; other site 137722005251 membrane-bound complex binding site; other site 137722005252 hinge residues; other site 137722005253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722005254 dimerization interface [polypeptide binding]; other site 137722005255 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 137722005256 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722005257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722005258 active site 137722005259 phosphorylation site [posttranslational modification] 137722005260 intermolecular recognition site; other site 137722005261 dimerization interface [polypeptide binding]; other site 137722005262 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722005263 DNA binding site [nucleotide binding] 137722005264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722005265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722005266 ATP binding site [chemical binding]; other site 137722005267 Mg2+ binding site [ion binding]; other site 137722005268 G-X-G motif; other site 137722005269 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 137722005270 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722005271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722005272 active site 137722005273 phosphorylation site [posttranslational modification] 137722005274 intermolecular recognition site; other site 137722005275 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 137722005276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722005277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722005278 dimer interface [polypeptide binding]; other site 137722005279 phosphorylation site [posttranslational modification] 137722005280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722005281 ATP binding site [chemical binding]; other site 137722005282 Mg2+ binding site [ion binding]; other site 137722005283 G-X-G motif; other site 137722005284 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 137722005285 Histidine kinase; Region: HisKA_2; pfam07568 137722005286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722005287 ATP binding site [chemical binding]; other site 137722005288 Mg2+ binding site [ion binding]; other site 137722005289 G-X-G motif; other site 137722005290 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 137722005291 metal binding site [ion binding]; metal-binding site 137722005292 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722005293 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722005294 ligand binding site [chemical binding]; other site 137722005295 flexible hinge region; other site 137722005296 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 137722005297 putative switch regulator; other site 137722005298 non-specific DNA interactions [nucleotide binding]; other site 137722005299 DNA binding site [nucleotide binding] 137722005300 sequence specific DNA binding site [nucleotide binding]; other site 137722005301 putative cAMP binding site [chemical binding]; other site 137722005302 Uncharacterized conserved protein [Function unknown]; Region: COG2928 137722005303 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 137722005304 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 137722005305 generic binding surface II; other site 137722005306 ssDNA binding site; other site 137722005307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 137722005308 ATP binding site [chemical binding]; other site 137722005309 putative Mg++ binding site [ion binding]; other site 137722005310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722005311 nucleotide binding region [chemical binding]; other site 137722005312 ATP-binding site [chemical binding]; other site 137722005313 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 137722005314 putative binding surface; other site 137722005315 active site 137722005316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722005317 ATP binding site [chemical binding]; other site 137722005318 Mg2+ binding site [ion binding]; other site 137722005319 G-X-G motif; other site 137722005320 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 137722005321 Response regulator receiver domain; Region: Response_reg; pfam00072 137722005322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722005323 active site 137722005324 phosphorylation site [posttranslational modification] 137722005325 intermolecular recognition site; other site 137722005326 dimerization interface [polypeptide binding]; other site 137722005327 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 137722005328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722005329 active site 137722005330 phosphorylation site [posttranslational modification] 137722005331 intermolecular recognition site; other site 137722005332 CheB methylesterase; Region: CheB_methylest; pfam01339 137722005333 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 137722005334 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 137722005335 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 137722005336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722005337 dimer interface [polypeptide binding]; other site 137722005338 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 137722005339 putative CheW interface [polypeptide binding]; other site 137722005340 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 137722005341 dimerization interface [polypeptide binding]; other site 137722005342 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722005343 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722005344 dimer interface [polypeptide binding]; other site 137722005345 putative CheW interface [polypeptide binding]; other site 137722005346 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 137722005347 YceG-like family; Region: YceG; pfam02618 137722005348 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 137722005349 dimerization interface [polypeptide binding]; other site 137722005350 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 137722005351 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 137722005352 dimer interface [polypeptide binding]; other site 137722005353 active site 137722005354 acyl carrier protein; Provisional; Region: acpP; PRK00982 137722005355 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 137722005356 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 137722005357 NAD(P) binding site [chemical binding]; other site 137722005358 homotetramer interface [polypeptide binding]; other site 137722005359 homodimer interface [polypeptide binding]; other site 137722005360 active site 137722005361 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 137722005362 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 137722005363 Acyltransferase family; Region: Acyl_transf_3; pfam01757 137722005364 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 137722005365 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 137722005366 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 137722005367 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 137722005368 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 137722005369 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 137722005370 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 137722005371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722005372 S-adenosylmethionine binding site [chemical binding]; other site 137722005373 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722005374 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722005375 metal binding site [ion binding]; metal-binding site 137722005376 active site 137722005377 I-site; other site 137722005378 isocitrate dehydrogenase; Validated; Region: PRK08299 137722005379 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 137722005380 NAD(P) binding site [chemical binding]; other site 137722005381 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 137722005382 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 137722005383 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 137722005384 GcrA cell cycle regulator; Region: GcrA; cl11564 137722005385 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 137722005386 Putative zinc-finger; Region: zf-HC2; pfam13490 137722005387 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 137722005388 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722005389 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722005390 DNA binding residues [nucleotide binding] 137722005391 isocitrate dehydrogenase; Validated; Region: PRK09222 137722005392 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 137722005393 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 137722005394 DNA-binding interface [nucleotide binding]; DNA binding site 137722005395 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 137722005396 integral membrane protein; Region: integ_memb_HG; TIGR03954 137722005397 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722005398 dimerization interface [polypeptide binding]; other site 137722005399 putative DNA binding site [nucleotide binding]; other site 137722005400 putative Zn2+ binding site [ion binding]; other site 137722005401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 137722005402 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 137722005403 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 137722005404 Zn2+ binding site [ion binding]; other site 137722005405 Mg2+ binding site [ion binding]; other site 137722005406 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 137722005407 4Fe-4S binding domain; Region: Fer4_5; pfam12801 137722005408 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 137722005409 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 137722005410 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 137722005411 classical (c) SDRs; Region: SDR_c; cd05233 137722005412 NAD(P) binding site [chemical binding]; other site 137722005413 active site 137722005414 amidophosphoribosyltransferase; Provisional; Region: PRK09123 137722005415 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 137722005416 active site 137722005417 tetramer interface [polypeptide binding]; other site 137722005418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 137722005419 active site 137722005420 Colicin V production protein; Region: Colicin_V; pfam02674 137722005421 DNA repair protein RadA; Provisional; Region: PRK11823 137722005422 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 137722005423 Walker A motif/ATP binding site; other site 137722005424 ATP binding site [chemical binding]; other site 137722005425 Walker B motif; other site 137722005426 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 137722005427 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 137722005428 Sel1-like repeats; Region: SEL1; smart00671 137722005429 Sel1-like repeats; Region: SEL1; smart00671 137722005430 Sel1-like repeats; Region: SEL1; smart00671 137722005431 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 137722005432 active site 137722005433 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 137722005434 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 137722005435 dimer interface [polypeptide binding]; other site 137722005436 ADP-ribose binding site [chemical binding]; other site 137722005437 active site 137722005438 nudix motif; other site 137722005439 metal binding site [ion binding]; metal-binding site 137722005440 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 137722005441 putative active site [active] 137722005442 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 137722005443 GTP-binding protein Der; Reviewed; Region: PRK00093 137722005444 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 137722005445 G1 box; other site 137722005446 GTP/Mg2+ binding site [chemical binding]; other site 137722005447 Switch I region; other site 137722005448 G2 box; other site 137722005449 Switch II region; other site 137722005450 G3 box; other site 137722005451 G4 box; other site 137722005452 G5 box; other site 137722005453 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 137722005454 G1 box; other site 137722005455 GTP/Mg2+ binding site [chemical binding]; other site 137722005456 Switch I region; other site 137722005457 G2 box; other site 137722005458 G3 box; other site 137722005459 Switch II region; other site 137722005460 G4 box; other site 137722005461 G5 box; other site 137722005462 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 137722005463 PQQ-like domain; Region: PQQ_2; pfam13360 137722005464 Trp docking motif [polypeptide binding]; other site 137722005465 active site 137722005466 PQQ-like domain; Region: PQQ_2; pfam13360 137722005467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 137722005468 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 137722005469 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 137722005470 MutS domain I; Region: MutS_I; pfam01624 137722005471 MutS domain II; Region: MutS_II; pfam05188 137722005472 MutS domain III; Region: MutS_III; pfam05192 137722005473 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 137722005474 Walker A/P-loop; other site 137722005475 ATP binding site [chemical binding]; other site 137722005476 Q-loop/lid; other site 137722005477 ABC transporter signature motif; other site 137722005478 Walker B; other site 137722005479 D-loop; other site 137722005480 H-loop/switch region; other site 137722005481 PII uridylyl-transferase; Provisional; Region: PRK05092 137722005482 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 137722005483 metal binding triad; other site 137722005484 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 137722005485 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 137722005486 Zn2+ binding site [ion binding]; other site 137722005487 Mg2+ binding site [ion binding]; other site 137722005488 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 137722005489 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 137722005490 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722005491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722005492 active site 137722005493 phosphorylation site [posttranslational modification] 137722005494 intermolecular recognition site; other site 137722005495 dimerization interface [polypeptide binding]; other site 137722005496 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722005497 DNA binding residues [nucleotide binding] 137722005498 dimerization interface [polypeptide binding]; other site 137722005499 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722005500 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722005501 DNA binding residues [nucleotide binding] 137722005502 dimerization interface [polypeptide binding]; other site 137722005503 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 137722005504 HAMP domain; Region: HAMP; pfam00672 137722005505 dimerization interface [polypeptide binding]; other site 137722005506 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722005507 dimer interface [polypeptide binding]; other site 137722005508 putative CheW interface [polypeptide binding]; other site 137722005509 PilZ domain; Region: PilZ; pfam07238 137722005510 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 137722005511 dimer interface [polypeptide binding]; other site 137722005512 putative tRNA-binding site [nucleotide binding]; other site 137722005513 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722005514 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722005515 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722005516 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722005517 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 137722005518 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 137722005519 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 137722005520 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 137722005521 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 137722005522 Phasin protein; Region: Phasin_2; pfam09361 137722005523 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 137722005524 putative deacylase active site [active] 137722005525 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 137722005526 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 137722005527 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 137722005528 Membrane fusogenic activity; Region: BMFP; pfam04380 137722005529 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 137722005530 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 137722005531 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 137722005532 Protein of unknown function (DUF1192); Region: DUF1192; cl11573 137722005533 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 137722005534 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 137722005535 NAD(P) binding site [chemical binding]; other site 137722005536 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 137722005537 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 137722005538 Flavoprotein; Region: Flavoprotein; pfam02441 137722005539 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 137722005540 active site clefts [active] 137722005541 zinc binding site [ion binding]; other site 137722005542 dimer interface [polypeptide binding]; other site 137722005543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722005544 binding surface 137722005545 TPR repeat; Region: TPR_11; pfam13414 137722005546 TPR motif; other site 137722005547 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722005548 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 137722005549 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 137722005550 6-phosphofructokinase; Provisional; Region: PRK14071 137722005551 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 137722005552 active site 137722005553 ADP/pyrophosphate binding site [chemical binding]; other site 137722005554 dimerization interface [polypeptide binding]; other site 137722005555 allosteric effector site; other site 137722005556 fructose-1,6-bisphosphate binding site; other site 137722005557 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 137722005558 apolar tunnel; other site 137722005559 heme binding site [chemical binding]; other site 137722005560 dimerization interface [polypeptide binding]; other site 137722005561 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 137722005562 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 137722005563 ATP-grasp domain; Region: ATP-grasp; pfam02222 137722005564 PAS fold; Region: PAS; pfam00989 137722005565 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722005566 Protein of unknown function, DUF599; Region: DUF599; pfam04654 137722005567 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 137722005568 fumarate hydratase; Reviewed; Region: fumC; PRK00485 137722005569 Class II fumarases; Region: Fumarase_classII; cd01362 137722005570 active site 137722005571 tetramer interface [polypeptide binding]; other site 137722005572 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 137722005573 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722005574 Coenzyme A binding pocket [chemical binding]; other site 137722005575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 137722005576 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 137722005577 Transglycosylase SLT domain; Region: SLT_2; pfam13406 137722005578 murein hydrolase B; Provisional; Region: PRK10760; cl17906 137722005579 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 137722005580 Response regulator receiver domain; Region: Response_reg; pfam00072 137722005581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722005582 active site 137722005583 phosphorylation site [posttranslational modification] 137722005584 intermolecular recognition site; other site 137722005585 dimerization interface [polypeptide binding]; other site 137722005586 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 137722005587 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 137722005588 dimer interface [polypeptide binding]; other site 137722005589 PYR/PP interface [polypeptide binding]; other site 137722005590 TPP binding site [chemical binding]; other site 137722005591 substrate binding site [chemical binding]; other site 137722005592 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 137722005593 TPP-binding site; other site 137722005594 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 137722005595 PAS fold; Region: PAS_7; pfam12860 137722005596 PAS domain; Region: PAS; smart00091 137722005597 PAS fold; Region: PAS_7; pfam12860 137722005598 putative active site [active] 137722005599 heme pocket [chemical binding]; other site 137722005600 PAS fold; Region: PAS_4; pfam08448 137722005601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 137722005602 dimer interface [polypeptide binding]; other site 137722005603 phosphorylation site [posttranslational modification] 137722005604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722005605 ATP binding site [chemical binding]; other site 137722005606 Mg2+ binding site [ion binding]; other site 137722005607 G-X-G motif; other site 137722005608 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 137722005609 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 137722005610 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722005611 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722005612 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722005613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722005614 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 137722005615 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 137722005616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722005617 dimerization interface [polypeptide binding]; other site 137722005618 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722005619 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722005620 dimer interface [polypeptide binding]; other site 137722005621 putative CheW interface [polypeptide binding]; other site 137722005622 BON domain; Region: BON; pfam04972 137722005623 Response regulator receiver domain; Region: Response_reg; pfam00072 137722005624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722005625 active site 137722005626 phosphorylation site [posttranslational modification] 137722005627 intermolecular recognition site; other site 137722005628 dimerization interface [polypeptide binding]; other site 137722005629 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 137722005630 anti sigma factor interaction site; other site 137722005631 regulatory phosphorylation site [posttranslational modification]; other site 137722005632 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 137722005633 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 137722005634 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 137722005635 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 137722005636 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722005637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722005638 putative substrate translocation pore; other site 137722005639 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 137722005640 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 137722005641 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 137722005642 phosphopeptide binding site; other site 137722005643 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 137722005644 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 137722005645 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 137722005646 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 137722005647 Protein of unknown function (DUF796); Region: DUF796; pfam05638 137722005648 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 137722005649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722005650 Walker A motif; other site 137722005651 ATP binding site [chemical binding]; other site 137722005652 Walker B motif; other site 137722005653 arginine finger; other site 137722005654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722005655 Walker A motif; other site 137722005656 ATP binding site [chemical binding]; other site 137722005657 Walker B motif; other site 137722005658 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 137722005659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722005660 S-adenosylmethionine binding site [chemical binding]; other site 137722005661 PAAR motif; Region: PAAR_motif; pfam05488 137722005662 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 137722005663 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 137722005664 Protein of unknown function (DUF770); Region: DUF770; pfam05591 137722005665 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 137722005666 Protein of unknown function (DUF877); Region: DUF877; pfam05943 137722005667 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 137722005668 Protein of unknown function (DUF877); Region: DUF877; pfam05943 137722005669 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 137722005670 ImpE protein; Region: ImpE; pfam07024 137722005671 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 137722005672 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 137722005673 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 137722005674 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 137722005675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722005676 S-adenosylmethionine binding site [chemical binding]; other site 137722005677 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 137722005678 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 137722005679 Sel1-like repeats; Region: SEL1; smart00671 137722005680 Sel1-like repeats; Region: SEL1; smart00671 137722005681 Sel1-like repeats; Region: SEL1; smart00671 137722005682 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 137722005683 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 137722005684 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 137722005685 ligand binding site [chemical binding]; other site 137722005686 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 137722005687 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 137722005688 G1 box; other site 137722005689 GTP/Mg2+ binding site [chemical binding]; other site 137722005690 G2 box; other site 137722005691 Switch I region; other site 137722005692 G3 box; other site 137722005693 Switch II region; other site 137722005694 G4 box; other site 137722005695 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 137722005696 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 137722005697 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 137722005698 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 137722005699 active site 137722005700 ATP binding site [chemical binding]; other site 137722005701 substrate binding site [chemical binding]; other site 137722005702 activation loop (A-loop); other site 137722005703 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 137722005704 Response regulator receiver domain; Region: Response_reg; pfam00072 137722005705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722005706 active site 137722005707 phosphorylation site [posttranslational modification] 137722005708 intermolecular recognition site; other site 137722005709 dimerization interface [polypeptide binding]; other site 137722005710 PAS fold; Region: PAS_7; pfam12860 137722005711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722005712 dimer interface [polypeptide binding]; other site 137722005713 phosphorylation site [posttranslational modification] 137722005714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722005715 ATP binding site [chemical binding]; other site 137722005716 G-X-G motif; other site 137722005717 Response regulator receiver domain; Region: Response_reg; pfam00072 137722005718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722005719 active site 137722005720 phosphorylation site [posttranslational modification] 137722005721 intermolecular recognition site; other site 137722005722 dimerization interface [polypeptide binding]; other site 137722005723 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 137722005724 active site 137722005725 multimer interface [polypeptide binding]; other site 137722005726 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 137722005727 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 137722005728 choline dehydrogenase; Validated; Region: PRK02106 137722005729 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 137722005730 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 137722005731 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 137722005732 NAD(P) binding site [chemical binding]; other site 137722005733 catalytic residues [active] 137722005734 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 137722005735 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 137722005736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 137722005737 ABC transporter; Region: ABC_tran_2; pfam12848 137722005738 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 137722005739 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 137722005740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722005741 S-adenosylmethionine binding site [chemical binding]; other site 137722005742 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 137722005743 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 137722005744 Uncharacterized conserved protein [Function unknown]; Region: COG1434 137722005745 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 137722005746 putative active site [active] 137722005747 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 137722005748 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 137722005749 Sporulation related domain; Region: SPOR; pfam05036 137722005750 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 137722005751 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 137722005752 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 137722005753 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 137722005754 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 137722005755 TMP-binding site; other site 137722005756 ATP-binding site [chemical binding]; other site 137722005757 DNA polymerase III subunit delta'; Validated; Region: PRK07471 137722005758 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 137722005759 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 137722005760 active site 137722005761 HIGH motif; other site 137722005762 KMSKS motif; other site 137722005763 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 137722005764 tRNA binding surface [nucleotide binding]; other site 137722005765 anticodon binding site; other site 137722005766 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 137722005767 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 137722005768 active site 137722005769 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 137722005770 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 137722005771 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 137722005772 OpgC protein; Region: OpgC_C; pfam10129 137722005773 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 137722005774 oxyanion hole [active] 137722005775 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 137722005776 active site 137722005777 catalytic triad [active] 137722005778 oxyanion hole [active] 137722005779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722005780 PAS fold; Region: PAS_3; pfam08447 137722005781 putative active site [active] 137722005782 heme pocket [chemical binding]; other site 137722005783 PAS fold; Region: PAS_3; pfam08447 137722005784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722005785 putative active site [active] 137722005786 heme pocket [chemical binding]; other site 137722005787 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722005788 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722005789 metal binding site [ion binding]; metal-binding site 137722005790 active site 137722005791 I-site; other site 137722005792 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722005793 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 137722005794 Recombination protein O N terminal; Region: RecO_N; pfam11967 137722005795 Recombination protein O C terminal; Region: RecO_C; pfam02565 137722005796 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 137722005797 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 137722005798 CAP-like domain; other site 137722005799 active site 137722005800 primary dimer interface [polypeptide binding]; other site 137722005801 Uncharacterized conserved protein [Function unknown]; Region: COG3334 137722005802 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 137722005803 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 137722005804 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 137722005805 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 137722005806 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 137722005807 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 137722005808 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 137722005809 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 137722005810 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 137722005811 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 137722005812 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 137722005813 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 137722005814 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 137722005815 flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787 137722005816 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 137722005817 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 137722005818 Rod binding protein; Region: Rod-binding; cl01626 137722005819 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 137722005820 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 137722005821 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 137722005822 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 137722005823 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 137722005824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722005825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722005826 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 137722005827 putative active site [active] 137722005828 putative catalytic site [active] 137722005829 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 137722005830 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 137722005831 enoyl-CoA hydratase; Provisional; Region: PRK07511 137722005832 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722005833 substrate binding site [chemical binding]; other site 137722005834 oxyanion hole (OAH) forming residues; other site 137722005835 trimer interface [polypeptide binding]; other site 137722005836 PAS fold; Region: PAS; pfam00989 137722005837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722005838 PAS domain; Region: PAS_9; pfam13426 137722005839 putative active site [active] 137722005840 heme pocket [chemical binding]; other site 137722005841 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722005842 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722005843 dimer interface [polypeptide binding]; other site 137722005844 putative CheW interface [polypeptide binding]; other site 137722005845 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 137722005846 DNA protecting protein DprA; Region: dprA; TIGR00732 137722005847 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 137722005848 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 137722005849 active site 137722005850 interdomain interaction site; other site 137722005851 putative metal-binding site [ion binding]; other site 137722005852 nucleotide binding site [chemical binding]; other site 137722005853 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 137722005854 domain I; other site 137722005855 DNA binding groove [nucleotide binding] 137722005856 phosphate binding site [ion binding]; other site 137722005857 domain II; other site 137722005858 domain III; other site 137722005859 nucleotide binding site [chemical binding]; other site 137722005860 catalytic site [active] 137722005861 domain IV; other site 137722005862 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 137722005863 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 137722005864 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 137722005865 enoyl-CoA hydratase; Validated; Region: PRK08139 137722005866 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722005867 substrate binding site [chemical binding]; other site 137722005868 oxyanion hole (OAH) forming residues; other site 137722005869 trimer interface [polypeptide binding]; other site 137722005870 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 137722005871 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 137722005872 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 137722005873 homodimer interface [polypeptide binding]; other site 137722005874 substrate-cofactor binding pocket; other site 137722005875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722005876 catalytic residue [active] 137722005877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722005878 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722005879 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 137722005880 classical (c) SDRs; Region: SDR_c; cd05233 137722005881 NAD(P) binding site [chemical binding]; other site 137722005882 active site 137722005883 hypothetical protein; Provisional; Region: PRK09256 137722005884 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 137722005885 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 137722005886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722005887 S-adenosylmethionine binding site [chemical binding]; other site 137722005888 AzlC protein; Region: AzlC; cl00570 137722005889 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 137722005890 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 137722005891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722005892 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722005893 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 137722005894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 137722005895 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 137722005896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 137722005897 ATP binding site [chemical binding]; other site 137722005898 putative Mg++ binding site [ion binding]; other site 137722005899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722005900 nucleotide binding region [chemical binding]; other site 137722005901 ATP-binding site [chemical binding]; other site 137722005902 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 137722005903 active site 137722005904 response regulator PleD; Reviewed; Region: pleD; PRK09581 137722005905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722005906 active site 137722005907 phosphorylation site [posttranslational modification] 137722005908 intermolecular recognition site; other site 137722005909 dimerization interface [polypeptide binding]; other site 137722005910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722005911 active site 137722005912 phosphorylation site [posttranslational modification] 137722005913 intermolecular recognition site; other site 137722005914 dimerization interface [polypeptide binding]; other site 137722005915 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722005916 metal binding site [ion binding]; metal-binding site 137722005917 active site 137722005918 I-site; other site 137722005919 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722005920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722005921 active site 137722005922 phosphorylation site [posttranslational modification] 137722005923 intermolecular recognition site; other site 137722005924 dimerization interface [polypeptide binding]; other site 137722005925 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722005926 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722005927 metal binding site [ion binding]; metal-binding site 137722005928 active site 137722005929 I-site; other site 137722005930 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 137722005931 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 137722005932 dimerization interface [polypeptide binding]; other site 137722005933 ligand binding site [chemical binding]; other site 137722005934 NADP binding site [chemical binding]; other site 137722005935 catalytic site [active] 137722005936 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 137722005937 recombination factor protein RarA; Reviewed; Region: PRK13342 137722005938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722005939 Walker A motif; other site 137722005940 ATP binding site [chemical binding]; other site 137722005941 Walker B motif; other site 137722005942 arginine finger; other site 137722005943 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 137722005944 Predicted membrane protein [Function unknown]; Region: COG1238 137722005945 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 137722005946 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 137722005947 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 137722005948 alphaNTD - beta interaction site [polypeptide binding]; other site 137722005949 alphaNTD homodimer interface [polypeptide binding]; other site 137722005950 alphaNTD - beta' interaction site [polypeptide binding]; other site 137722005951 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 137722005952 30S ribosomal protein S11; Validated; Region: PRK05309 137722005953 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 137722005954 30S ribosomal protein S13; Region: bact_S13; TIGR03631 137722005955 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 137722005956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722005957 TPR motif; other site 137722005958 binding surface 137722005959 TPR repeat; Region: TPR_11; pfam13414 137722005960 elongation factor G; Reviewed; Region: PRK00007 137722005961 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 137722005962 G1 box; other site 137722005963 putative GEF interaction site [polypeptide binding]; other site 137722005964 GTP/Mg2+ binding site [chemical binding]; other site 137722005965 Switch I region; other site 137722005966 G2 box; other site 137722005967 G3 box; other site 137722005968 Switch II region; other site 137722005969 G4 box; other site 137722005970 G5 box; other site 137722005971 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 137722005972 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 137722005973 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 137722005974 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 137722005975 homotrimer interaction site [polypeptide binding]; other site 137722005976 putative active site [active] 137722005977 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 137722005978 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 137722005979 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 137722005980 active site 137722005981 interdomain interaction site; other site 137722005982 putative metal-binding site [ion binding]; other site 137722005983 nucleotide binding site [chemical binding]; other site 137722005984 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 137722005985 domain I; other site 137722005986 DNA binding groove [nucleotide binding] 137722005987 phosphate binding site [ion binding]; other site 137722005988 domain II; other site 137722005989 domain III; other site 137722005990 nucleotide binding site [chemical binding]; other site 137722005991 catalytic site [active] 137722005992 domain IV; other site 137722005993 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722005994 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722005995 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722005996 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722005997 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722005998 ligand binding site [chemical binding]; other site 137722005999 flexible hinge region; other site 137722006000 putative switch regulator; other site 137722006001 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 137722006002 non-specific DNA interactions [nucleotide binding]; other site 137722006003 DNA binding site [nucleotide binding] 137722006004 sequence specific DNA binding site [nucleotide binding]; other site 137722006005 putative cAMP binding site [chemical binding]; other site 137722006006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722006007 non-specific DNA binding site [nucleotide binding]; other site 137722006008 salt bridge; other site 137722006009 sequence-specific DNA binding site [nucleotide binding]; other site 137722006010 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722006011 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722006012 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722006013 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722006014 active site 137722006015 DNA binding site [nucleotide binding] 137722006016 Int/Topo IB signature motif; other site 137722006017 Helix-turn-helix domain; Region: HTH_36; pfam13730 137722006018 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722006019 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722006020 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722006021 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722006022 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 137722006023 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722006024 Winged helix-turn helix; Region: HTH_29; pfam13551 137722006025 Winged helix-turn helix; Region: HTH_33; pfam13592 137722006026 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722006027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 137722006028 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 137722006029 Transposase domain (DUF772); Region: DUF772; pfam05598 137722006030 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722006031 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 137722006032 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 137722006033 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722006034 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722006035 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722006036 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722006037 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722006038 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722006039 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 137722006040 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 137722006041 IHF dimer interface [polypeptide binding]; other site 137722006042 IHF - DNA interface [nucleotide binding]; other site 137722006043 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 137722006044 Found in ATP-dependent protease La (LON); Region: LON; smart00464 137722006045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722006046 Walker A motif; other site 137722006047 ATP binding site [chemical binding]; other site 137722006048 Walker B motif; other site 137722006049 arginine finger; other site 137722006050 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 137722006051 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722006052 dimer interface [polypeptide binding]; other site 137722006053 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 137722006054 putative CheW interface [polypeptide binding]; other site 137722006055 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 137722006056 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 137722006057 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 137722006058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722006059 Walker A motif; other site 137722006060 ATP binding site [chemical binding]; other site 137722006061 Walker B motif; other site 137722006062 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 137722006063 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 137722006064 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 137722006065 oligomer interface [polypeptide binding]; other site 137722006066 active site residues [active] 137722006067 trigger factor; Provisional; Region: tig; PRK01490 137722006068 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 137722006069 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 137722006070 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 137722006071 Uncharacterized conserved protein [Function unknown]; Region: COG0062 137722006072 putative carbohydrate kinase; Provisional; Region: PRK10565 137722006073 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 137722006074 putative substrate binding site [chemical binding]; other site 137722006075 putative ATP binding site [chemical binding]; other site 137722006076 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 137722006077 Nitrogen regulatory protein P-II; Region: P-II; smart00938 137722006078 glutamine synthetase; Provisional; Region: glnA; PRK09469 137722006079 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 137722006080 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 137722006081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722006082 Response regulator receiver domain; Region: Response_reg; pfam00072 137722006083 active site 137722006084 phosphorylation site [posttranslational modification] 137722006085 intermolecular recognition site; other site 137722006086 dimerization interface [polypeptide binding]; other site 137722006087 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 137722006088 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 137722006089 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 137722006090 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 137722006091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722006092 Coenzyme A binding pocket [chemical binding]; other site 137722006093 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 137722006094 TPR repeat; Region: TPR_11; pfam13414 137722006095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722006096 binding surface 137722006097 TPR motif; other site 137722006098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722006099 TPR motif; other site 137722006100 binding surface 137722006101 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 137722006102 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 137722006103 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 137722006104 Stringent starvation protein B; Region: SspB; cl01120 137722006105 TfoX N-terminal domain; Region: TfoX_N; pfam04993 137722006106 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 137722006107 COQ9; Region: COQ9; pfam08511 137722006108 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 137722006109 active site 137722006110 catalytic residues [active] 137722006111 metal binding site [ion binding]; metal-binding site 137722006112 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 137722006113 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 137722006114 oligomerization interface [polypeptide binding]; other site 137722006115 active site 137722006116 metal binding site [ion binding]; metal-binding site 137722006117 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 137722006118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 137722006119 ATP binding site [chemical binding]; other site 137722006120 putative Mg++ binding site [ion binding]; other site 137722006121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722006122 nucleotide binding region [chemical binding]; other site 137722006123 ATP-binding site [chemical binding]; other site 137722006124 DEAD/H associated; Region: DEAD_assoc; pfam08494 137722006125 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 137722006126 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 137722006127 putative active site [active] 137722006128 putative metal binding site [ion binding]; other site 137722006129 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 137722006130 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 137722006131 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 137722006132 metal binding site 2 [ion binding]; metal-binding site 137722006133 putative DNA binding helix; other site 137722006134 metal binding site 1 [ion binding]; metal-binding site 137722006135 dimer interface [polypeptide binding]; other site 137722006136 structural Zn2+ binding site [ion binding]; other site 137722006137 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 137722006138 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 137722006139 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 137722006140 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 137722006141 Zn binding site [ion binding]; other site 137722006142 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 137722006143 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 137722006144 putative active site pocket [active] 137722006145 dimerization interface [polypeptide binding]; other site 137722006146 putative catalytic residue [active] 137722006147 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 137722006148 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 137722006149 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 137722006150 putative active site [active] 137722006151 putative dimer interface [polypeptide binding]; other site 137722006152 Response regulator receiver domain; Region: Response_reg; pfam00072 137722006153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722006154 active site 137722006155 phosphorylation site [posttranslational modification] 137722006156 intermolecular recognition site; other site 137722006157 dimerization interface [polypeptide binding]; other site 137722006158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722006159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722006160 dimer interface [polypeptide binding]; other site 137722006161 phosphorylation site [posttranslational modification] 137722006162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722006163 ATP binding site [chemical binding]; other site 137722006164 Mg2+ binding site [ion binding]; other site 137722006165 G-X-G motif; other site 137722006166 DNA polymerase III subunit chi; Validated; Region: PRK05728 137722006167 multifunctional aminopeptidase A; Provisional; Region: PRK00913 137722006168 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 137722006169 interface (dimer of trimers) [polypeptide binding]; other site 137722006170 Substrate-binding/catalytic site; other site 137722006171 Zn-binding sites [ion binding]; other site 137722006172 ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563 137722006173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722006174 S-adenosylmethionine binding site [chemical binding]; other site 137722006175 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 137722006176 MltA specific insert domain; Region: MltA; smart00925 137722006177 3D domain; Region: 3D; pfam06725 137722006178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 137722006179 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 137722006180 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 137722006181 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 137722006182 PAS domain; Region: PAS; smart00091 137722006183 putative active site [active] 137722006184 heme pocket [chemical binding]; other site 137722006185 GAF domain; Region: GAF; pfam01590 137722006186 Phytochrome region; Region: PHY; pfam00360 137722006187 HWE histidine kinase; Region: HWE_HK; smart00911 137722006188 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 137722006189 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 137722006190 dimer interface [polypeptide binding]; other site 137722006191 ADP-ribose binding site [chemical binding]; other site 137722006192 active site 137722006193 nudix motif; other site 137722006194 metal binding site [ion binding]; metal-binding site 137722006195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722006196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722006197 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722006198 dimerization interface [polypeptide binding]; other site 137722006199 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 137722006200 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 137722006201 Walker A/P-loop; other site 137722006202 ATP binding site [chemical binding]; other site 137722006203 Q-loop/lid; other site 137722006204 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 137722006205 Q-loop/lid; other site 137722006206 ABC transporter signature motif; other site 137722006207 Walker B; other site 137722006208 D-loop; other site 137722006209 H-loop/switch region; other site 137722006210 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 137722006211 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 137722006212 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 137722006213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722006214 active site 137722006215 phosphorylation site [posttranslational modification] 137722006216 intermolecular recognition site; other site 137722006217 dimerization interface [polypeptide binding]; other site 137722006218 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 137722006219 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 137722006220 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 137722006221 active site 137722006222 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 137722006223 putative metal binding site [ion binding]; other site 137722006224 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 137722006225 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 137722006226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722006227 S-adenosylmethionine binding site [chemical binding]; other site 137722006228 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 137722006229 Part of AAA domain; Region: AAA_19; pfam13245 137722006230 Family description; Region: UvrD_C_2; pfam13538 137722006231 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722006232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722006233 active site 137722006234 phosphorylation site [posttranslational modification] 137722006235 intermolecular recognition site; other site 137722006236 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722006237 DNA binding residues [nucleotide binding] 137722006238 dimerization interface [polypeptide binding]; other site 137722006239 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722006240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722006241 active site 137722006242 phosphorylation site [posttranslational modification] 137722006243 intermolecular recognition site; other site 137722006244 dimerization interface [polypeptide binding]; other site 137722006245 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722006246 DNA binding residues [nucleotide binding] 137722006247 dimerization interface [polypeptide binding]; other site 137722006248 Domain of unknown function (DUF307); Region: DUF307; pfam03733 137722006249 hypothetical protein; Provisional; Region: PRK11770 137722006250 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 137722006251 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 137722006252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722006253 ATP binding site [chemical binding]; other site 137722006254 Mg2+ binding site [ion binding]; other site 137722006255 G-X-G motif; other site 137722006256 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 137722006257 ATP binding site [chemical binding]; other site 137722006258 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 137722006259 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 137722006260 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 137722006261 NADH(P)-binding; Region: NAD_binding_10; pfam13460 137722006262 NAD binding site [chemical binding]; other site 137722006263 putative active site [active] 137722006264 substrate binding site [chemical binding]; other site 137722006265 Predicted transcriptional regulators [Transcription]; Region: COG1733 137722006266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722006267 dimerization interface [polypeptide binding]; other site 137722006268 putative DNA binding site [nucleotide binding]; other site 137722006269 putative Zn2+ binding site [ion binding]; other site 137722006270 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 137722006271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722006272 putative substrate translocation pore; other site 137722006273 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 137722006274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 137722006275 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 137722006276 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 137722006277 RNA binding surface [nucleotide binding]; other site 137722006278 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 137722006279 active site 137722006280 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 137722006281 nucleoside/Zn binding site; other site 137722006282 dimer interface [polypeptide binding]; other site 137722006283 catalytic motif [active] 137722006284 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 137722006285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722006286 putative active site [active] 137722006287 heme pocket [chemical binding]; other site 137722006288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722006289 putative active site [active] 137722006290 heme pocket [chemical binding]; other site 137722006291 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722006292 dimer interface [polypeptide binding]; other site 137722006293 putative CheW interface [polypeptide binding]; other site 137722006294 HAMP domain; Region: HAMP; pfam00672 137722006295 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722006296 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722006297 dimer interface [polypeptide binding]; other site 137722006298 putative CheW interface [polypeptide binding]; other site 137722006299 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 137722006300 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 137722006301 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 137722006302 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 137722006303 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 137722006304 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 137722006305 generic binding surface II; other site 137722006306 generic binding surface I; other site 137722006307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722006308 binding surface 137722006309 TPR motif; other site 137722006310 TPR repeat; Region: TPR_11; pfam13414 137722006311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722006312 binding surface 137722006313 TPR repeat; Region: TPR_11; pfam13414 137722006314 TPR motif; other site 137722006315 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722006316 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 137722006317 active site 137722006318 substrate binding pocket [chemical binding]; other site 137722006319 dimer interface [polypeptide binding]; other site 137722006320 histidyl-tRNA synthetase; Region: hisS; TIGR00442 137722006321 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 137722006322 dimer interface [polypeptide binding]; other site 137722006323 motif 1; other site 137722006324 active site 137722006325 motif 2; other site 137722006326 motif 3; other site 137722006327 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 137722006328 anticodon binding site; other site 137722006329 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 137722006330 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 137722006331 Transglycosylase; Region: Transgly; cl17702 137722006332 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 137722006333 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 137722006334 5S rRNA interface [nucleotide binding]; other site 137722006335 CTC domain interface [polypeptide binding]; other site 137722006336 L16 interface [polypeptide binding]; other site 137722006337 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 137722006338 putative active site [active] 137722006339 catalytic residue [active] 137722006340 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 137722006341 Isochorismatase family; Region: Isochorismatase; pfam00857 137722006342 catalytic triad [active] 137722006343 conserved cis-peptide bond; other site 137722006344 pantoate--beta-alanine ligase; Region: panC; TIGR00018 137722006345 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 137722006346 GTP-binding protein YchF; Reviewed; Region: PRK09601 137722006347 YchF GTPase; Region: YchF; cd01900 137722006348 G1 box; other site 137722006349 GTP/Mg2+ binding site [chemical binding]; other site 137722006350 Switch I region; other site 137722006351 G2 box; other site 137722006352 Switch II region; other site 137722006353 G3 box; other site 137722006354 G4 box; other site 137722006355 G5 box; other site 137722006356 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 137722006357 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722006358 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 137722006359 nudix motif; other site 137722006360 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722006361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722006362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722006363 dimerization interface [polypeptide binding]; other site 137722006364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722006365 putative substrate translocation pore; other site 137722006366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722006367 NADH dehydrogenase; Validated; Region: PRK08183 137722006368 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 137722006369 mce related protein; Region: MCE; pfam02470 137722006370 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 137722006371 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 137722006372 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 137722006373 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 137722006374 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 137722006375 trimer interface [polypeptide binding]; other site 137722006376 active site 137722006377 substrate binding site [chemical binding]; other site 137722006378 Transcriptional regulator; Region: Rrf2; cl17282 137722006379 Rrf2 family protein; Region: rrf2_super; TIGR00738 137722006380 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 137722006381 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 137722006382 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722006383 catalytic residue [active] 137722006384 Double zinc ribbon; Region: DZR; pfam12773 137722006385 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 137722006386 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722006387 catalytic loop [active] 137722006388 iron binding site [ion binding]; other site 137722006389 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 137722006390 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 137722006391 Ligand Binding Site [chemical binding]; other site 137722006392 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722006393 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 137722006394 catalytic residues [active] 137722006395 catalytic nucleophile [active] 137722006396 Recombinase; Region: Recombinase; pfam07508 137722006397 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 137722006398 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 137722006399 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 137722006400 substrate interaction site [chemical binding]; other site 137722006401 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 137722006402 Methyltransferase domain; Region: Methyltransf_27; pfam13708 137722006403 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 137722006404 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 137722006405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722006406 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 137722006407 Walker A motif; other site 137722006408 ATP binding site [chemical binding]; other site 137722006409 Walker B motif; other site 137722006410 arginine finger; other site 137722006411 Helix-turn-helix domain; Region: HTH_36; pfam13730 137722006412 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 137722006413 ParB-like nuclease domain; Region: ParBc; pfam02195 137722006414 Methyltransferase domain; Region: Methyltransf_26; pfam13659 137722006415 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 137722006416 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 137722006417 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 137722006418 active site 137722006419 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 137722006420 Phage-related protein [Function unknown]; Region: COG4695; cl01923 137722006421 Phage portal protein; Region: Phage_portal; pfam04860 137722006422 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 137722006423 oligomer interface [polypeptide binding]; other site 137722006424 active site residues [active] 137722006425 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 137722006426 Phage capsid family; Region: Phage_capsid; pfam05065 137722006427 Src homology 2 (SH2) domain; Region: SH2; cl15255 137722006428 phosphotyrosine binding pocket [polypeptide binding]; other site 137722006429 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 137722006430 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 137722006431 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722006432 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722006433 catalytic residue [active] 137722006434 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 137722006435 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 137722006436 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 137722006437 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 137722006438 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 137722006439 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 137722006440 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722006441 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722006442 substrate binding pocket [chemical binding]; other site 137722006443 membrane-bound complex binding site; other site 137722006444 hinge residues; other site 137722006445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 137722006446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722006447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722006448 Predicted amidohydrolase [General function prediction only]; Region: COG0388 137722006449 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 137722006450 putative active site [active] 137722006451 catalytic triad [active] 137722006452 putative dimer interface [polypeptide binding]; other site 137722006453 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 137722006454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722006455 active site 137722006456 phosphorylation site [posttranslational modification] 137722006457 intermolecular recognition site; other site 137722006458 dimerization interface [polypeptide binding]; other site 137722006459 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722006460 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722006461 metal binding site [ion binding]; metal-binding site 137722006462 active site 137722006463 I-site; other site 137722006464 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 137722006465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722006466 Walker A motif; other site 137722006467 ATP binding site [chemical binding]; other site 137722006468 Walker B motif; other site 137722006469 arginine finger; other site 137722006470 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722006471 5-oxoprolinase; Region: PLN02666 137722006472 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 137722006473 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 137722006474 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 137722006475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722006476 Coenzyme A binding pocket [chemical binding]; other site 137722006477 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 137722006478 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 137722006479 putative metal binding site [ion binding]; other site 137722006480 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 137722006481 HSP70 interaction site [polypeptide binding]; other site 137722006482 ABC transporter ATPase component; Reviewed; Region: PRK11147 137722006483 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 137722006484 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 137722006485 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 137722006486 EamA-like transporter family; Region: EamA; pfam00892 137722006487 EamA-like transporter family; Region: EamA; pfam00892 137722006488 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 137722006489 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 137722006490 amidase catalytic site [active] 137722006491 Zn binding residues [ion binding]; other site 137722006492 substrate binding site [chemical binding]; other site 137722006493 cell division protein MraZ; Reviewed; Region: PRK00326 137722006494 MraZ protein; Region: MraZ; pfam02381 137722006495 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 137722006496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722006497 S-adenosylmethionine binding site [chemical binding]; other site 137722006498 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 137722006499 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 137722006500 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 137722006501 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 137722006502 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 137722006503 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 137722006504 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 137722006505 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 137722006506 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 137722006507 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 137722006508 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 137722006509 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 137722006510 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 137722006511 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 137722006512 Mg++ binding site [ion binding]; other site 137722006513 putative catalytic motif [active] 137722006514 putative substrate binding site [chemical binding]; other site 137722006515 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 137722006516 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 137722006517 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 137722006518 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 137722006519 cell division protein FtsW; Region: ftsW; TIGR02614 137722006520 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 137722006521 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 137722006522 active site 137722006523 homodimer interface [polypeptide binding]; other site 137722006524 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 137722006525 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 137722006526 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 137722006527 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 137722006528 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 137722006529 FAD binding domain; Region: FAD_binding_4; pfam01565 137722006530 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 137722006531 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 137722006532 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 137722006533 ATP-grasp domain; Region: ATP-grasp_4; cl17255 137722006534 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 137722006535 Cell division protein FtsQ; Region: FtsQ; pfam03799 137722006536 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 137722006537 Cell division protein FtsA; Region: FtsA; smart00842 137722006538 Cell division protein FtsA; Region: FtsA; pfam14450 137722006539 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 137722006540 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 137722006541 nucleotide binding site [chemical binding]; other site 137722006542 SulA interaction site; other site 137722006543 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 137722006544 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 137722006545 Hemerythrin; Region: Hemerythrin; cd12107 137722006546 Fe binding site [ion binding]; other site 137722006547 Ligase N family; Region: LIGANc; smart00532 137722006548 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 137722006549 nucleotide binding pocket [chemical binding]; other site 137722006550 K-X-D-G motif; other site 137722006551 catalytic site [active] 137722006552 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 137722006553 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 137722006554 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 137722006555 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 137722006556 Dimer interface [polypeptide binding]; other site 137722006557 BRCT sequence motif; other site 137722006558 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 137722006559 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 137722006560 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 137722006561 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 137722006562 active site 137722006563 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 137722006564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722006565 S-adenosylmethionine binding site [chemical binding]; other site 137722006566 exopolyphosphatase; Region: exo_poly_only; TIGR03706 137722006567 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 137722006568 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 137722006569 ABC1 family; Region: ABC1; pfam03109 137722006570 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 137722006571 active site 137722006572 ATP binding site [chemical binding]; other site 137722006573 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 137722006574 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 137722006575 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 137722006576 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 137722006577 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 137722006578 epoxyqueuosine reductase; Region: TIGR00276 137722006579 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 137722006580 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 137722006581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722006582 Coenzyme A binding pocket [chemical binding]; other site 137722006583 Sterol carrier protein domain; Region: SCP2_2; pfam13530 137722006584 HAMP domain; Region: HAMP; pfam00672 137722006585 dimerization interface [polypeptide binding]; other site 137722006586 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722006587 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 137722006588 dimer interface [polypeptide binding]; other site 137722006589 putative CheW interface [polypeptide binding]; other site 137722006590 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 137722006591 putative active site [active] 137722006592 putative metal binding residues [ion binding]; other site 137722006593 signature motif; other site 137722006594 putative dimer interface [polypeptide binding]; other site 137722006595 putative phosphate binding site [ion binding]; other site 137722006596 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 137722006597 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608 137722006598 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 137722006599 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 137722006600 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 137722006601 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 137722006602 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 137722006603 putative ligand binding site [chemical binding]; other site 137722006604 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 137722006605 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722006606 TM-ABC transporter signature motif; other site 137722006607 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722006608 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 137722006609 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 137722006610 TM-ABC transporter signature motif; other site 137722006611 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 137722006612 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 137722006613 Walker A/P-loop; other site 137722006614 ATP binding site [chemical binding]; other site 137722006615 Q-loop/lid; other site 137722006616 ABC transporter signature motif; other site 137722006617 Walker B; other site 137722006618 D-loop; other site 137722006619 H-loop/switch region; other site 137722006620 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 137722006621 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 137722006622 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 137722006623 PRC-barrel domain; Region: PRC; pfam05239 137722006624 ATP12 chaperone protein; Region: ATP12; cl02228 137722006625 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 137722006626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722006627 motif II; other site 137722006628 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 137722006629 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 137722006630 RNA binding surface [nucleotide binding]; other site 137722006631 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 137722006632 active site 137722006633 camphor resistance protein CrcB; Provisional; Region: PRK14195 137722006634 Isochorismatase family; Region: Isochorismatase; pfam00857 137722006635 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 137722006636 catalytic triad [active] 137722006637 conserved cis-peptide bond; other site 137722006638 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 137722006639 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 137722006640 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 137722006641 Walker A/P-loop; other site 137722006642 ATP binding site [chemical binding]; other site 137722006643 Q-loop/lid; other site 137722006644 ABC transporter signature motif; other site 137722006645 Walker B; other site 137722006646 D-loop; other site 137722006647 H-loop/switch region; other site 137722006648 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 137722006649 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 137722006650 FtsX-like permease family; Region: FtsX; pfam02687 137722006651 prolyl-tRNA synthetase; Provisional; Region: PRK12325 137722006652 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 137722006653 dimer interface [polypeptide binding]; other site 137722006654 motif 1; other site 137722006655 active site 137722006656 motif 2; other site 137722006657 motif 3; other site 137722006658 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 137722006659 anticodon binding site; other site 137722006660 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722006661 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722006662 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722006663 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722006664 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 137722006665 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 137722006666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 137722006667 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 137722006668 dimer interface [polypeptide binding]; other site 137722006669 substrate binding site [chemical binding]; other site 137722006670 metal binding site [ion binding]; metal-binding site 137722006671 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 137722006672 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 137722006673 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 137722006674 pantothenate kinase; Reviewed; Region: PRK13318 137722006675 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 137722006676 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 137722006677 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 137722006678 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 137722006679 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 137722006680 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 137722006681 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 137722006682 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 137722006683 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 137722006684 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 137722006685 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 137722006686 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 137722006687 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 137722006688 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 137722006689 4Fe-4S binding domain; Region: Fer4; cl02805 137722006690 4Fe-4S binding domain; Region: Fer4; pfam00037 137722006691 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 137722006692 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 137722006693 NADH dehydrogenase subunit G; Validated; Region: PRK09130 137722006694 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722006695 catalytic loop [active] 137722006696 iron binding site [ion binding]; other site 137722006697 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 137722006698 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 137722006699 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 137722006700 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 137722006701 SLBB domain; Region: SLBB; pfam10531 137722006702 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 137722006703 NADH dehydrogenase subunit E; Validated; Region: PRK07539 137722006704 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 137722006705 putative dimer interface [polypeptide binding]; other site 137722006706 [2Fe-2S] cluster binding site [ion binding]; other site 137722006707 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 137722006708 NADH dehydrogenase subunit D; Validated; Region: PRK06075 137722006709 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 137722006710 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 137722006711 NADH dehydrogenase subunit B; Validated; Region: PRK06411 137722006712 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 137722006713 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 137722006714 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 137722006715 catalytic residues [active] 137722006716 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 137722006717 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 137722006718 acyl-activating enzyme (AAE) consensus motif; other site 137722006719 putative AMP binding site [chemical binding]; other site 137722006720 putative active site [active] 137722006721 putative CoA binding site [chemical binding]; other site 137722006722 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 137722006723 Lysine efflux permease [General function prediction only]; Region: COG1279 137722006724 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 137722006725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722006726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722006727 dimerization interface [polypeptide binding]; other site 137722006728 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 137722006729 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 137722006730 active site 137722006731 Zn binding site [ion binding]; other site 137722006732 Hemerythrin; Region: Hemerythrin; cd12107 137722006733 Fe binding site [ion binding]; other site 137722006734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 137722006735 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 137722006736 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 137722006737 metal binding site [ion binding]; metal-binding site 137722006738 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 137722006739 PhoU domain; Region: PhoU; pfam01895 137722006740 PhoU domain; Region: PhoU; pfam01895 137722006741 hypothetical protein; Provisional; Region: PRK05208 137722006742 rod shape-determining protein MreB; Provisional; Region: PRK13927 137722006743 MreB and similar proteins; Region: MreB_like; cd10225 137722006744 nucleotide binding site [chemical binding]; other site 137722006745 Mg binding site [ion binding]; other site 137722006746 putative protofilament interaction site [polypeptide binding]; other site 137722006747 RodZ interaction site [polypeptide binding]; other site 137722006748 rod shape-determining protein MreC; Provisional; Region: PRK13922 137722006749 rod shape-determining protein MreC; Region: MreC; pfam04085 137722006750 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 137722006751 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 137722006752 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 137722006753 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 137722006754 ketol-acid reductoisomerase; Provisional; Region: PRK05479 137722006755 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 137722006756 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 137722006757 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 137722006758 putative active site [active] 137722006759 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 137722006760 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 137722006761 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 137722006762 putative valine binding site [chemical binding]; other site 137722006763 dimer interface [polypeptide binding]; other site 137722006764 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 137722006765 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 137722006766 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 137722006767 PYR/PP interface [polypeptide binding]; other site 137722006768 dimer interface [polypeptide binding]; other site 137722006769 TPP binding site [chemical binding]; other site 137722006770 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 137722006771 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 137722006772 TPP-binding site [chemical binding]; other site 137722006773 dimer interface [polypeptide binding]; other site 137722006774 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 137722006775 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722006776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722006777 homodimer interface [polypeptide binding]; other site 137722006778 catalytic residue [active] 137722006779 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 137722006780 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 137722006781 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 137722006782 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 137722006783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722006784 motif II; other site 137722006785 Hemerythrin; Region: Hemerythrin; cd12107 137722006786 Fe binding site [ion binding]; other site 137722006787 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 137722006788 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 137722006789 NAD binding site [chemical binding]; other site 137722006790 homotetramer interface [polypeptide binding]; other site 137722006791 homodimer interface [polypeptide binding]; other site 137722006792 substrate binding site [chemical binding]; other site 137722006793 active site 137722006794 PRC-barrel domain; Region: PRC; pfam05239 137722006795 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 137722006796 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 137722006797 UreF; Region: UreF; pfam01730 137722006798 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 137722006799 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 137722006800 dimer interface [polypeptide binding]; other site 137722006801 catalytic residues [active] 137722006802 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 137722006803 urease subunit alpha; Reviewed; Region: ureC; PRK13207 137722006804 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 137722006805 subunit interactions [polypeptide binding]; other site 137722006806 active site 137722006807 flap region; other site 137722006808 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 137722006809 gamma-beta subunit interface [polypeptide binding]; other site 137722006810 alpha-beta subunit interface [polypeptide binding]; other site 137722006811 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 137722006812 alpha-gamma subunit interface [polypeptide binding]; other site 137722006813 beta-gamma subunit interface [polypeptide binding]; other site 137722006814 UreD urease accessory protein; Region: UreD; pfam01774 137722006815 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722006816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722006817 active site 137722006818 phosphorylation site [posttranslational modification] 137722006819 intermolecular recognition site; other site 137722006820 dimerization interface [polypeptide binding]; other site 137722006821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722006822 DNA binding residues [nucleotide binding] 137722006823 dimerization interface [polypeptide binding]; other site 137722006824 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722006825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722006826 active site 137722006827 phosphorylation site [posttranslational modification] 137722006828 intermolecular recognition site; other site 137722006829 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722006830 DNA binding residues [nucleotide binding] 137722006831 dimerization interface [polypeptide binding]; other site 137722006832 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 137722006833 intracellular protease, PfpI family; Region: PfpI; TIGR01382 137722006834 proposed catalytic triad [active] 137722006835 conserved cys residue [active] 137722006836 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 137722006837 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 137722006838 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 137722006839 hinge; other site 137722006840 active site 137722006841 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 137722006842 trimer interface [polypeptide binding]; other site 137722006843 active site 137722006844 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 137722006845 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 137722006846 putative NAD(P) binding site [chemical binding]; other site 137722006847 active site 137722006848 putative substrate binding site [chemical binding]; other site 137722006849 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 137722006850 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 137722006851 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 137722006852 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 137722006853 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 137722006854 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 137722006855 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 137722006856 Transposase domain (DUF772); Region: DUF772; pfam05598 137722006857 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722006858 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 137722006859 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 137722006860 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722006861 active site 137722006862 Int/Topo IB signature motif; other site 137722006863 DNA binding site [nucleotide binding] 137722006864 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 137722006865 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 137722006866 Mg++ binding site [ion binding]; other site 137722006867 putative catalytic motif [active] 137722006868 putative substrate binding site [chemical binding]; other site 137722006869 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 137722006870 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 137722006871 Probable Catalytic site; other site 137722006872 metal-binding site 137722006873 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 137722006874 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 137722006875 Probable Catalytic site; other site 137722006876 metal-binding site 137722006877 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 137722006878 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 137722006879 putative NAD(P) binding site [chemical binding]; other site 137722006880 active site 137722006881 putative substrate binding site [chemical binding]; other site 137722006882 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 137722006883 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 137722006884 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 137722006885 NAD(P) binding site [chemical binding]; other site 137722006886 homodimer interface [polypeptide binding]; other site 137722006887 substrate binding site [chemical binding]; other site 137722006888 active site 137722006889 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 137722006890 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 137722006891 Tetramer interface [polypeptide binding]; other site 137722006892 active site 137722006893 FMN-binding site [chemical binding]; other site 137722006894 ribonuclease R; Region: RNase_R; TIGR02063 137722006895 RNB domain; Region: RNB; pfam00773 137722006896 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 137722006897 RNA binding site [nucleotide binding]; other site 137722006898 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 137722006899 protein binding site [polypeptide binding]; other site 137722006900 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 137722006901 Catalytic dyad [active] 137722006902 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 137722006903 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 137722006904 LrgA family; Region: LrgA; pfam03788 137722006905 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 137722006906 2-isopropylmalate synthase; Validated; Region: PRK03739 137722006907 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 137722006908 active site 137722006909 catalytic residues [active] 137722006910 metal binding site [ion binding]; metal-binding site 137722006911 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 137722006912 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 137722006913 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 137722006914 NADP binding site [chemical binding]; other site 137722006915 homopentamer interface [polypeptide binding]; other site 137722006916 substrate binding site [chemical binding]; other site 137722006917 active site 137722006918 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 137722006919 Uncharacterized conserved protein [Function unknown]; Region: COG1565 137722006920 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 137722006921 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 137722006922 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 137722006923 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 137722006924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 137722006925 active site 137722006926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722006927 sequence-specific DNA binding site [nucleotide binding]; other site 137722006928 salt bridge; other site 137722006929 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722006930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722006931 non-specific DNA binding site [nucleotide binding]; other site 137722006932 salt bridge; other site 137722006933 sequence-specific DNA binding site [nucleotide binding]; other site 137722006934 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 137722006935 Catalytic site [active] 137722006936 Uncharacterized conserved protein [Function unknown]; Region: COG2128 137722006937 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 137722006938 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 137722006939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722006940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 137722006941 dimer interface [polypeptide binding]; other site 137722006942 phosphorylation site [posttranslational modification] 137722006943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722006944 ATP binding site [chemical binding]; other site 137722006945 Mg2+ binding site [ion binding]; other site 137722006946 G-X-G motif; other site 137722006947 Response regulator receiver domain; Region: Response_reg; pfam00072 137722006948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722006949 active site 137722006950 phosphorylation site [posttranslational modification] 137722006951 intermolecular recognition site; other site 137722006952 dimerization interface [polypeptide binding]; other site 137722006953 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 137722006954 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 137722006955 Walker A/P-loop; other site 137722006956 ATP binding site [chemical binding]; other site 137722006957 Q-loop/lid; other site 137722006958 ABC transporter signature motif; other site 137722006959 Walker B; other site 137722006960 D-loop; other site 137722006961 H-loop/switch region; other site 137722006962 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 137722006963 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722006964 Nif-specific regulatory protein; Region: nifA; TIGR01817 137722006965 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 137722006966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722006967 Walker A motif; other site 137722006968 ATP binding site [chemical binding]; other site 137722006969 Walker B motif; other site 137722006970 arginine finger; other site 137722006971 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722006972 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 137722006973 cyclase homology domain; Region: CHD; cd07302 137722006974 dimer interface [polypeptide binding]; other site 137722006975 nucleotidyl binding site; other site 137722006976 metal binding site [ion binding]; metal-binding site 137722006977 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 137722006978 phosphopeptide binding site; other site 137722006979 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 137722006980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722006981 FeS/SAM binding site; other site 137722006982 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 137722006983 hypothetical protein; Provisional; Region: PRK13795 137722006984 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 137722006985 NifZ domain; Region: NifZ; pfam04319 137722006986 NifZ domain; Region: NifZ; pfam04319 137722006987 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 137722006988 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 137722006989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722006990 catalytic residue [active] 137722006991 NifT/FixU protein; Region: NifT; pfam06988 137722006992 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 137722006993 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722006994 catalytic residue [active] 137722006995 SIR2-like domain; Region: SIR2_2; pfam13289 137722006996 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 137722006997 intracellular septation protein A; Reviewed; Region: PRK00259 137722006998 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 137722006999 Sporulation related domain; Region: SPOR; pfam05036 137722007000 Response regulator receiver domain; Region: Response_reg; pfam00072 137722007001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007002 active site 137722007003 phosphorylation site [posttranslational modification] 137722007004 intermolecular recognition site; other site 137722007005 dimerization interface [polypeptide binding]; other site 137722007006 PAS fold; Region: PAS; pfam00989 137722007007 PAS domain; Region: PAS; smart00091 137722007008 putative active site [active] 137722007009 heme pocket [chemical binding]; other site 137722007010 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 137722007011 active site 137722007012 catalytic site [active] 137722007013 substrate binding site [chemical binding]; other site 137722007014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722007015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722007016 ATP binding site [chemical binding]; other site 137722007017 Mg2+ binding site [ion binding]; other site 137722007018 G-X-G motif; other site 137722007019 Response regulator receiver domain; Region: Response_reg; pfam00072 137722007020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007021 active site 137722007022 phosphorylation site [posttranslational modification] 137722007023 intermolecular recognition site; other site 137722007024 dimerization interface [polypeptide binding]; other site 137722007025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722007026 PAS domain; Region: PAS_9; pfam13426 137722007027 putative active site [active] 137722007028 heme pocket [chemical binding]; other site 137722007029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722007030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722007031 ATP binding site [chemical binding]; other site 137722007032 Mg2+ binding site [ion binding]; other site 137722007033 G-X-G motif; other site 137722007034 PAS domain S-box; Region: sensory_box; TIGR00229 137722007035 PAS domain; Region: PAS_8; pfam13188 137722007036 PAS fold; Region: PAS_7; pfam12860 137722007037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722007038 dimer interface [polypeptide binding]; other site 137722007039 phosphorylation site [posttranslational modification] 137722007040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722007041 ATP binding site [chemical binding]; other site 137722007042 Mg2+ binding site [ion binding]; other site 137722007043 G-X-G motif; other site 137722007044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007045 Response regulator receiver domain; Region: Response_reg; pfam00072 137722007046 active site 137722007047 phosphorylation site [posttranslational modification] 137722007048 intermolecular recognition site; other site 137722007049 dimerization interface [polypeptide binding]; other site 137722007050 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 137722007051 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 137722007052 active site residue [active] 137722007053 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 137722007054 ATP binding site [chemical binding]; other site 137722007055 substrate interface [chemical binding]; other site 137722007056 Uncharacterized conserved protein [Function unknown]; Region: COG3482 137722007057 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 137722007058 YcaO-like family; Region: YcaO; pfam02624 137722007059 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 137722007060 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722007061 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722007062 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 137722007063 dimer interface [polypeptide binding]; other site 137722007064 motif 1; other site 137722007065 active site 137722007066 motif 2; other site 137722007067 motif 3; other site 137722007068 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 137722007069 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 137722007070 Response regulator receiver domain; Region: Response_reg; pfam00072 137722007071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007072 active site 137722007073 phosphorylation site [posttranslational modification] 137722007074 intermolecular recognition site; other site 137722007075 dimerization interface [polypeptide binding]; other site 137722007076 PIN domain; Region: PIN_3; cl17397 137722007077 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 137722007078 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 137722007079 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 137722007080 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 137722007081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 137722007082 Zn2+ binding site [ion binding]; other site 137722007083 Mg2+ binding site [ion binding]; other site 137722007084 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 137722007085 transmembrane helices; other site 137722007086 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 137722007087 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 137722007088 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 137722007089 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 137722007090 dimerization interface [polypeptide binding]; other site 137722007091 ATP binding site [chemical binding]; other site 137722007092 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 137722007093 dimerization interface [polypeptide binding]; other site 137722007094 ATP binding site [chemical binding]; other site 137722007095 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 137722007096 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 137722007097 putative active site [active] 137722007098 catalytic triad [active] 137722007099 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 137722007100 peptidase PmbA; Provisional; Region: PRK11040 137722007101 Predicted membrane protein [Function unknown]; Region: COG2259 137722007102 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 137722007103 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 137722007104 active site 137722007105 HIGH motif; other site 137722007106 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 137722007107 KMSKS motif; other site 137722007108 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 137722007109 tRNA binding surface [nucleotide binding]; other site 137722007110 anticodon binding site; other site 137722007111 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 137722007112 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 137722007113 active site 137722007114 HIGH motif; other site 137722007115 KMSKS motif; other site 137722007116 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 137722007117 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 137722007118 conserved cys residue [active] 137722007119 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 137722007120 NAD synthetase; Provisional; Region: PRK13981 137722007121 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 137722007122 active site 137722007123 catalytic triad [active] 137722007124 dimer interface [polypeptide binding]; other site 137722007125 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 137722007126 Ligand Binding Site [chemical binding]; other site 137722007127 SnoaL-like domain; Region: SnoaL_4; cl17707 137722007128 SnoaL-like domain; Region: SnoaL_3; pfam13474 137722007129 Beta-lactamase; Region: Beta-lactamase; cl17358 137722007130 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 137722007131 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 137722007132 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 137722007133 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 137722007134 Ligand binding site; other site 137722007135 Putative Catalytic site; other site 137722007136 DXD motif; other site 137722007137 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 137722007138 HAMP domain; Region: HAMP; pfam00672 137722007139 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722007140 dimer interface [polypeptide binding]; other site 137722007141 putative CheW interface [polypeptide binding]; other site 137722007142 Protein of unknown function, DUF462; Region: DUF462; cl01190 137722007143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722007144 dimerization interface [polypeptide binding]; other site 137722007145 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722007146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722007147 dimer interface [polypeptide binding]; other site 137722007148 putative CheW interface [polypeptide binding]; other site 137722007149 Predicted permeases [General function prediction only]; Region: COG0679 137722007150 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 137722007151 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 137722007152 putative deacylase active site [active] 137722007153 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 137722007154 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 137722007155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722007156 binding surface 137722007157 TPR motif; other site 137722007158 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 137722007159 Uncharacterized conserved protein [Function unknown]; Region: COG2835 137722007160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 137722007161 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 137722007162 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 137722007163 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 137722007164 NAD(P) binding site [chemical binding]; other site 137722007165 homotetramer interface [polypeptide binding]; other site 137722007166 homodimer interface [polypeptide binding]; other site 137722007167 active site 137722007168 putative acyltransferase; Provisional; Region: PRK05790 137722007169 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 137722007170 dimer interface [polypeptide binding]; other site 137722007171 active site 137722007172 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 137722007173 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 137722007174 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 137722007175 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 137722007176 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 137722007177 Methyltransferase domain; Region: Methyltransf_31; pfam13847 137722007178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722007179 S-adenosylmethionine binding site [chemical binding]; other site 137722007180 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 137722007181 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 137722007182 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 137722007183 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 137722007184 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 137722007185 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 137722007186 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 137722007187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722007188 Walker A/P-loop; other site 137722007189 ATP binding site [chemical binding]; other site 137722007190 Q-loop/lid; other site 137722007191 ABC transporter signature motif; other site 137722007192 Walker B; other site 137722007193 D-loop; other site 137722007194 H-loop/switch region; other site 137722007195 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 137722007196 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 137722007197 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 137722007198 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 137722007199 putative dimer interface [polypeptide binding]; other site 137722007200 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 137722007201 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 137722007202 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 137722007203 GTPase CgtA; Reviewed; Region: obgE; PRK12299 137722007204 GTP1/OBG; Region: GTP1_OBG; pfam01018 137722007205 Obg GTPase; Region: Obg; cd01898 137722007206 G1 box; other site 137722007207 GTP/Mg2+ binding site [chemical binding]; other site 137722007208 Switch I region; other site 137722007209 G2 box; other site 137722007210 G3 box; other site 137722007211 Switch II region; other site 137722007212 G4 box; other site 137722007213 G5 box; other site 137722007214 gamma-glutamyl kinase; Provisional; Region: PRK05429 137722007215 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 137722007216 nucleotide binding site [chemical binding]; other site 137722007217 homotetrameric interface [polypeptide binding]; other site 137722007218 putative phosphate binding site [ion binding]; other site 137722007219 putative allosteric binding site; other site 137722007220 PUA domain; Region: PUA; pfam01472 137722007221 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 137722007222 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722007223 motif II; other site 137722007224 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 137722007225 NodB motif; other site 137722007226 putative active site [active] 137722007227 putative catalytic site [active] 137722007228 Zn binding site [ion binding]; other site 137722007229 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 137722007230 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 137722007231 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 137722007232 protein binding site [polypeptide binding]; other site 137722007233 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 137722007234 Catalytic dyad [active] 137722007235 Peptidase family M23; Region: Peptidase_M23; pfam01551 137722007236 phosphoglyceromutase; Provisional; Region: PRK05434 137722007237 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 137722007238 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 137722007239 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 137722007240 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 137722007241 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 137722007242 active site 137722007243 (T/H)XGH motif; other site 137722007244 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 137722007245 putative catalytic cysteine [active] 137722007246 hypothetical protein; Provisional; Region: PRK10621 137722007247 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 137722007248 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 137722007249 putative active site [active] 137722007250 Ap4A binding site [chemical binding]; other site 137722007251 nudix motif; other site 137722007252 putative metal binding site [ion binding]; other site 137722007253 Response regulator receiver domain; Region: Response_reg; pfam00072 137722007254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007255 active site 137722007256 phosphorylation site [posttranslational modification] 137722007257 intermolecular recognition site; other site 137722007258 dimerization interface [polypeptide binding]; other site 137722007259 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 137722007260 putative binding surface; other site 137722007261 active site 137722007262 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 137722007263 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 137722007264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722007265 ATP binding site [chemical binding]; other site 137722007266 Mg2+ binding site [ion binding]; other site 137722007267 G-X-G motif; other site 137722007268 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 137722007269 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 137722007270 putative CheA interaction surface; other site 137722007271 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 137722007272 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 137722007273 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 137722007274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722007275 S-adenosylmethionine binding site [chemical binding]; other site 137722007276 CheD chemotactic sensory transduction; Region: CheD; cl00810 137722007277 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 137722007278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007279 active site 137722007280 phosphorylation site [posttranslational modification] 137722007281 intermolecular recognition site; other site 137722007282 dimerization interface [polypeptide binding]; other site 137722007283 CheB methylesterase; Region: CheB_methylest; pfam01339 137722007284 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722007285 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722007286 dimer interface [polypeptide binding]; other site 137722007287 putative CheW interface [polypeptide binding]; other site 137722007288 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 137722007289 anti sigma factor interaction site; other site 137722007290 regulatory phosphorylation site [posttranslational modification]; other site 137722007291 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 137722007292 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722007293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007294 active site 137722007295 phosphorylation site [posttranslational modification] 137722007296 intermolecular recognition site; other site 137722007297 dimerization interface [polypeptide binding]; other site 137722007298 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 137722007299 Response regulator receiver domain; Region: Response_reg; pfam00072 137722007300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007301 active site 137722007302 phosphorylation site [posttranslational modification] 137722007303 intermolecular recognition site; other site 137722007304 dimerization interface [polypeptide binding]; other site 137722007305 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 137722007306 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722007307 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722007308 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722007309 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 137722007310 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 137722007311 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 137722007312 RNA binding surface [nucleotide binding]; other site 137722007313 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722007314 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722007315 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722007316 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722007317 Predicted dehydrogenase [General function prediction only]; Region: COG0579 137722007318 hydroxyglutarate oxidase; Provisional; Region: PRK11728 137722007319 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 137722007320 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 137722007321 putative dimer interface [polypeptide binding]; other site 137722007322 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 137722007323 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722007324 dimerization interface [polypeptide binding]; other site 137722007325 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722007326 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722007327 dimer interface [polypeptide binding]; other site 137722007328 putative CheW interface [polypeptide binding]; other site 137722007329 PilZ domain; Region: PilZ; pfam07238 137722007330 RmuC family; Region: RmuC; pfam02646 137722007331 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 137722007332 nudix motif; other site 137722007333 Protein of unknown function, DUF399; Region: DUF399; pfam04187 137722007334 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 137722007335 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 137722007336 classical (c) SDRs; Region: SDR_c; cd05233 137722007337 NAD(P) binding site [chemical binding]; other site 137722007338 active site 137722007339 aspartate aminotransferase; Provisional; Region: PRK05764 137722007340 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722007341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722007342 homodimer interface [polypeptide binding]; other site 137722007343 catalytic residue [active] 137722007344 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 137722007345 Peptidase family M48; Region: Peptidase_M48; pfam01435 137722007346 TPR repeat; Region: TPR_11; pfam13414 137722007347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 137722007348 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 137722007349 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 137722007350 catalytic residues [active] 137722007351 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 137722007352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722007353 motif II; other site 137722007354 MT-A70; Region: MT-A70; cl01947 137722007355 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722007356 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722007357 ligand binding site [chemical binding]; other site 137722007358 flexible hinge region; other site 137722007359 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 137722007360 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 137722007361 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 137722007362 DNA-binding site [nucleotide binding]; DNA binding site 137722007363 RNA-binding motif; other site 137722007364 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 137722007365 DNA-binding site [nucleotide binding]; DNA binding site 137722007366 RNA-binding motif; other site 137722007367 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 137722007368 B1 nucleotide binding pocket [chemical binding]; other site 137722007369 B2 nucleotide binding pocket [chemical binding]; other site 137722007370 CAS motifs; other site 137722007371 active site 137722007372 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 137722007373 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 137722007374 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 137722007375 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 137722007376 catalytic triad [active] 137722007377 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 137722007378 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 137722007379 metal binding triad; other site 137722007380 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 137722007381 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 137722007382 metal binding triad; other site 137722007383 Protein of unknown function; Region: DUF3971; pfam13116 137722007384 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 137722007385 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 137722007386 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 137722007387 active site 137722007388 HIGH motif; other site 137722007389 dimer interface [polypeptide binding]; other site 137722007390 KMSKS motif; other site 137722007391 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 137722007392 RNA binding surface [nucleotide binding]; other site 137722007393 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 137722007394 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 137722007395 heme binding site [chemical binding]; other site 137722007396 ferroxidase pore; other site 137722007397 ferroxidase diiron center [ion binding]; other site 137722007398 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 137722007399 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 137722007400 heme binding site [chemical binding]; other site 137722007401 ferroxidase pore; other site 137722007402 ferroxidase diiron center [ion binding]; other site 137722007403 AAA domain; Region: AAA_31; pfam13614 137722007404 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722007405 P-loop; other site 137722007406 Magnesium ion binding site [ion binding]; other site 137722007407 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 137722007408 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 137722007409 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 137722007410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722007411 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 137722007412 dimerization interface [polypeptide binding]; other site 137722007413 substrate binding pocket [chemical binding]; other site 137722007414 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 137722007415 EamA-like transporter family; Region: EamA; pfam00892 137722007416 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 137722007417 FAD binding domain; Region: FAD_binding_4; pfam01565 137722007418 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 137722007419 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 137722007420 substrate binding site [chemical binding]; other site 137722007421 ligand binding site [chemical binding]; other site 137722007422 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 137722007423 nucleophilic elbow; other site 137722007424 catalytic triad; other site 137722007425 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722007426 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722007427 TM-ABC transporter signature motif; other site 137722007428 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722007429 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722007430 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722007431 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722007432 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 137722007433 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 137722007434 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 137722007435 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 137722007436 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 137722007437 Isochorismatase family; Region: Isochorismatase; pfam00857 137722007438 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 137722007439 catalytic triad [active] 137722007440 conserved cis-peptide bond; other site 137722007441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722007442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722007443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722007444 dimerization interface [polypeptide binding]; other site 137722007445 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 137722007446 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 137722007447 dimerization interface 3.5A [polypeptide binding]; other site 137722007448 active site 137722007449 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 137722007450 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 137722007451 putative active site [active] 137722007452 substrate binding site [chemical binding]; other site 137722007453 putative cosubstrate binding site; other site 137722007454 catalytic site [active] 137722007455 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 137722007456 substrate binding site [chemical binding]; other site 137722007457 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 137722007458 active site 137722007459 catalytic residues [active] 137722007460 metal binding site [ion binding]; metal-binding site 137722007461 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 137722007462 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 137722007463 catalytic core [active] 137722007464 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 137722007465 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 137722007466 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 137722007467 ATP binding site [chemical binding]; other site 137722007468 Mg++ binding site [ion binding]; other site 137722007469 motif III; other site 137722007470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722007471 nucleotide binding region [chemical binding]; other site 137722007472 ATP-binding site [chemical binding]; other site 137722007473 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 137722007474 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 137722007475 Transglycosylase; Region: Transgly; cl17702 137722007476 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 137722007477 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 137722007478 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 137722007479 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722007480 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722007481 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722007482 dimer interface [polypeptide binding]; other site 137722007483 putative CheW interface [polypeptide binding]; other site 137722007484 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722007485 HAMP domain; Region: HAMP; pfam00672 137722007486 dimerization interface [polypeptide binding]; other site 137722007487 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722007488 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722007489 dimer interface [polypeptide binding]; other site 137722007490 putative CheW interface [polypeptide binding]; other site 137722007491 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722007492 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722007493 metal binding site [ion binding]; metal-binding site 137722007494 active site 137722007495 I-site; other site 137722007496 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722007497 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 137722007498 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 137722007499 Predicted permeases [General function prediction only]; Region: COG0679 137722007500 tellurite resistance protein terB; Region: terB; cd07176 137722007501 putative metal binding site [ion binding]; other site 137722007502 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 137722007503 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 137722007504 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 137722007505 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 137722007506 active site 137722007507 catalytic residues [active] 137722007508 metal binding site [ion binding]; metal-binding site 137722007509 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 137722007510 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 137722007511 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 137722007512 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 137722007513 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722007514 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722007515 DNA binding residues [nucleotide binding] 137722007516 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 137722007517 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 137722007518 dimer interface [polypeptide binding]; other site 137722007519 putative functional site; other site 137722007520 putative MPT binding site; other site 137722007521 PBP superfamily domain; Region: PBP_like; pfam12727 137722007522 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 137722007523 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 137722007524 MPT binding site; other site 137722007525 Response regulator receiver domain; Region: Response_reg; pfam00072 137722007526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007527 active site 137722007528 phosphorylation site [posttranslational modification] 137722007529 intermolecular recognition site; other site 137722007530 dimerization interface [polypeptide binding]; other site 137722007531 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722007532 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722007533 metal binding site [ion binding]; metal-binding site 137722007534 active site 137722007535 I-site; other site 137722007536 PAS fold; Region: PAS; pfam00989 137722007537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722007538 putative active site [active] 137722007539 heme pocket [chemical binding]; other site 137722007540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722007541 dimer interface [polypeptide binding]; other site 137722007542 phosphorylation site [posttranslational modification] 137722007543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722007544 ATP binding site [chemical binding]; other site 137722007545 Mg2+ binding site [ion binding]; other site 137722007546 G-X-G motif; other site 137722007547 Response regulator receiver domain; Region: Response_reg; pfam00072 137722007548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007549 active site 137722007550 phosphorylation site [posttranslational modification] 137722007551 intermolecular recognition site; other site 137722007552 dimerization interface [polypeptide binding]; other site 137722007553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007554 active site 137722007555 phosphorylation site [posttranslational modification] 137722007556 intermolecular recognition site; other site 137722007557 dimerization interface [polypeptide binding]; other site 137722007558 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 137722007559 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 137722007560 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 137722007561 LytTr DNA-binding domain; Region: LytTR; smart00850 137722007562 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 137722007563 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 137722007564 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 137722007565 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 137722007566 trimer interface [polypeptide binding]; other site 137722007567 active site 137722007568 UDP-GlcNAc binding site [chemical binding]; other site 137722007569 lipid binding site [chemical binding]; lipid-binding site 137722007570 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 137722007571 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 137722007572 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 137722007573 ligand binding site [chemical binding]; other site 137722007574 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 137722007575 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 137722007576 acetyl-CoA synthetase; Provisional; Region: PRK00174 137722007577 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 137722007578 active site 137722007579 CoA binding site [chemical binding]; other site 137722007580 acyl-activating enzyme (AAE) consensus motif; other site 137722007581 AMP binding site [chemical binding]; other site 137722007582 acetate binding site [chemical binding]; other site 137722007583 EVE domain; Region: EVE; pfam01878 137722007584 YciI-like protein; Reviewed; Region: PRK12863 137722007585 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 137722007586 active site 137722007587 catalytic site [active] 137722007588 substrate binding site [chemical binding]; other site 137722007589 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 137722007590 ADP-ribose binding site [chemical binding]; other site 137722007591 dimer interface [polypeptide binding]; other site 137722007592 active site 137722007593 nudix motif; other site 137722007594 metal binding site [ion binding]; metal-binding site 137722007595 Methyltransferase domain; Region: Methyltransf_23; pfam13489 137722007596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722007597 S-adenosylmethionine binding site [chemical binding]; other site 137722007598 aconitate hydratase; Validated; Region: PRK09277 137722007599 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 137722007600 substrate binding site [chemical binding]; other site 137722007601 ligand binding site [chemical binding]; other site 137722007602 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 137722007603 substrate binding site [chemical binding]; other site 137722007604 HAMP domain; Region: HAMP; pfam00672 137722007605 PAS fold; Region: PAS_4; pfam08448 137722007606 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 137722007607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722007608 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 137722007609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722007610 ATP binding site [chemical binding]; other site 137722007611 Mg2+ binding site [ion binding]; other site 137722007612 G-X-G motif; other site 137722007613 Response regulator receiver domain; Region: Response_reg; pfam00072 137722007614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007615 active site 137722007616 phosphorylation site [posttranslational modification] 137722007617 intermolecular recognition site; other site 137722007618 dimerization interface [polypeptide binding]; other site 137722007619 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 137722007620 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 137722007621 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 137722007622 catalytic triad [active] 137722007623 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 137722007624 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 137722007625 NnrU protein; Region: NnrU; cl17713 137722007626 FOG: CBS domain [General function prediction only]; Region: COG0517 137722007627 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 137722007628 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 137722007629 DNA-binding site [nucleotide binding]; DNA binding site 137722007630 RNA-binding motif; other site 137722007631 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 137722007632 DNA-binding site [nucleotide binding]; DNA binding site 137722007633 RNA-binding motif; other site 137722007634 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 137722007635 PAS domain S-box; Region: sensory_box; TIGR00229 137722007636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722007637 putative active site [active] 137722007638 heme pocket [chemical binding]; other site 137722007639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722007640 dimer interface [polypeptide binding]; other site 137722007641 phosphorylation site [posttranslational modification] 137722007642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722007643 ATP binding site [chemical binding]; other site 137722007644 Mg2+ binding site [ion binding]; other site 137722007645 G-X-G motif; other site 137722007646 Response regulator receiver domain; Region: Response_reg; pfam00072 137722007647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722007648 active site 137722007649 phosphorylation site [posttranslational modification] 137722007650 intermolecular recognition site; other site 137722007651 dimerization interface [polypeptide binding]; other site 137722007652 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 137722007653 maleylacetoacetate isomerase; Region: maiA; TIGR01262 137722007654 C-terminal domain interface [polypeptide binding]; other site 137722007655 GSH binding site (G-site) [chemical binding]; other site 137722007656 putative dimer interface [polypeptide binding]; other site 137722007657 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 137722007658 dimer interface [polypeptide binding]; other site 137722007659 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 137722007660 N-terminal domain interface [polypeptide binding]; other site 137722007661 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722007662 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722007663 Walker A/P-loop; other site 137722007664 ATP binding site [chemical binding]; other site 137722007665 Q-loop/lid; other site 137722007666 ABC transporter signature motif; other site 137722007667 Walker B; other site 137722007668 D-loop; other site 137722007669 H-loop/switch region; other site 137722007670 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722007671 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722007672 Walker A/P-loop; other site 137722007673 ATP binding site [chemical binding]; other site 137722007674 Q-loop/lid; other site 137722007675 ABC transporter signature motif; other site 137722007676 Walker B; other site 137722007677 D-loop; other site 137722007678 H-loop/switch region; other site 137722007679 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722007680 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722007681 TM-ABC transporter signature motif; other site 137722007682 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722007683 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722007684 TM-ABC transporter signature motif; other site 137722007685 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 137722007686 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 137722007687 putative ligand binding site [chemical binding]; other site 137722007688 PaaX-like protein; Region: PaaX; pfam07848 137722007689 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 137722007690 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 137722007691 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 137722007692 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 137722007693 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722007694 catalytic loop [active] 137722007695 iron binding site [ion binding]; other site 137722007696 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 137722007697 FAD binding pocket [chemical binding]; other site 137722007698 FAD binding motif [chemical binding]; other site 137722007699 phosphate binding motif [ion binding]; other site 137722007700 beta-alpha-beta structure motif; other site 137722007701 NAD binding pocket [chemical binding]; other site 137722007702 Cache domain; Region: Cache_1; pfam02743 137722007703 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722007704 dimerization interface [polypeptide binding]; other site 137722007705 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722007706 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722007707 dimer interface [polypeptide binding]; other site 137722007708 putative CheW interface [polypeptide binding]; other site 137722007709 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 137722007710 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 137722007711 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 137722007712 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722007713 MarR family; Region: MarR_2; pfam12802 137722007714 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 137722007715 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 137722007716 putative trimer interface [polypeptide binding]; other site 137722007717 putative metal binding site [ion binding]; other site 137722007718 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 137722007719 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 137722007720 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 137722007721 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 137722007722 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 137722007723 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 137722007724 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 137722007725 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 137722007726 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 137722007727 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 137722007728 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 137722007729 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 137722007730 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 137722007731 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 137722007732 active site 137722007733 dimer interface [polypeptide binding]; other site 137722007734 motif 1; other site 137722007735 motif 2; other site 137722007736 motif 3; other site 137722007737 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 137722007738 anticodon binding site; other site 137722007739 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722007740 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 137722007741 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 137722007742 quinone interaction residues [chemical binding]; other site 137722007743 active site 137722007744 catalytic residues [active] 137722007745 FMN binding site [chemical binding]; other site 137722007746 substrate binding site [chemical binding]; other site 137722007747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 137722007748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 137722007749 DEAD-like helicases superfamily; Region: DEXDc; smart00487 137722007750 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 137722007751 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 137722007752 hypothetical protein; Region: PHA00661 137722007753 hypothetical protein; Region: PHA00662 137722007754 ferric uptake regulator; Provisional; Region: fur; PRK09462 137722007755 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 137722007756 metal binding site 2 [ion binding]; metal-binding site 137722007757 putative DNA binding helix; other site 137722007758 metal binding site 1 [ion binding]; metal-binding site 137722007759 dimer interface [polypeptide binding]; other site 137722007760 structural Zn2+ binding site [ion binding]; other site 137722007761 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 137722007762 E-class dimer interface [polypeptide binding]; other site 137722007763 P-class dimer interface [polypeptide binding]; other site 137722007764 active site 137722007765 Cu2+ binding site [ion binding]; other site 137722007766 Zn2+ binding site [ion binding]; other site 137722007767 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 137722007768 DEAD-like helicases superfamily; Region: DEXDc; smart00487 137722007769 ATP binding site [chemical binding]; other site 137722007770 Mg++ binding site [ion binding]; other site 137722007771 motif III; other site 137722007772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722007773 nucleotide binding region [chemical binding]; other site 137722007774 ATP-binding site [chemical binding]; other site 137722007775 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 137722007776 C-terminal domain interface [polypeptide binding]; other site 137722007777 GSH binding site (G-site) [chemical binding]; other site 137722007778 dimer interface [polypeptide binding]; other site 137722007779 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 137722007780 dimer interface [polypeptide binding]; other site 137722007781 N-terminal domain interface [polypeptide binding]; other site 137722007782 substrate binding pocket (H-site) [chemical binding]; other site 137722007783 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 137722007784 dinuclear metal binding motif [ion binding]; other site 137722007785 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 137722007786 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 137722007787 gamma subunit interface [polypeptide binding]; other site 137722007788 epsilon subunit interface [polypeptide binding]; other site 137722007789 LBP interface [polypeptide binding]; other site 137722007790 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 137722007791 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 137722007792 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 137722007793 alpha subunit interaction interface [polypeptide binding]; other site 137722007794 Walker A motif; other site 137722007795 ATP binding site [chemical binding]; other site 137722007796 Walker B motif; other site 137722007797 inhibitor binding site; inhibition site 137722007798 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 137722007799 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 137722007800 core domain interface [polypeptide binding]; other site 137722007801 delta subunit interface [polypeptide binding]; other site 137722007802 epsilon subunit interface [polypeptide binding]; other site 137722007803 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 137722007804 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 137722007805 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 137722007806 beta subunit interaction interface [polypeptide binding]; other site 137722007807 Walker A motif; other site 137722007808 ATP binding site [chemical binding]; other site 137722007809 Walker B motif; other site 137722007810 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 137722007811 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 137722007812 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 137722007813 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 137722007814 primosome assembly protein PriA; Validated; Region: PRK05580 137722007815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 137722007816 ATP binding site [chemical binding]; other site 137722007817 putative Mg++ binding site [ion binding]; other site 137722007818 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 137722007819 active site 137722007820 intersubunit interactions; other site 137722007821 catalytic residue [active] 137722007822 Protein of unknown function, DUF484; Region: DUF484; cl17449 137722007823 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 137722007824 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722007825 active site 137722007826 DNA binding site [nucleotide binding] 137722007827 Int/Topo IB signature motif; other site 137722007828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722007829 dimerization interface [polypeptide binding]; other site 137722007830 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722007831 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722007832 dimer interface [polypeptide binding]; other site 137722007833 putative CheW interface [polypeptide binding]; other site 137722007834 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 137722007835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 137722007836 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 137722007837 Flagellin N-methylase; Region: FliB; cl00497 137722007838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 137722007839 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 137722007840 SEC-C motif; Region: SEC-C; pfam02810 137722007841 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 137722007842 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 137722007843 putative ribose interaction site [chemical binding]; other site 137722007844 putative ADP binding site [chemical binding]; other site 137722007845 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 137722007846 active site 137722007847 nucleotide binding site [chemical binding]; other site 137722007848 HIGH motif; other site 137722007849 KMSKS motif; other site 137722007850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722007851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722007852 ATP binding site [chemical binding]; other site 137722007853 Mg2+ binding site [ion binding]; other site 137722007854 G-X-G motif; other site 137722007855 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722007856 ParA-like protein; Provisional; Region: PHA02518 137722007857 P-loop; other site 137722007858 Magnesium ion binding site [ion binding]; other site 137722007859 Uncharacterized conserved protein [Function unknown]; Region: COG3025 137722007860 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 137722007861 putative active site [active] 137722007862 putative metal binding residues [ion binding]; other site 137722007863 signature motif; other site 137722007864 putative triphosphate binding site [ion binding]; other site 137722007865 CHAD domain; Region: CHAD; pfam05235 137722007866 Phosphoglycerate kinase; Region: PGK; pfam00162 137722007867 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 137722007868 substrate binding site [chemical binding]; other site 137722007869 hinge regions; other site 137722007870 ADP binding site [chemical binding]; other site 137722007871 catalytic site [active] 137722007872 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 137722007873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722007874 Walker A motif; other site 137722007875 ATP binding site [chemical binding]; other site 137722007876 Walker B motif; other site 137722007877 arginine finger; other site 137722007878 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 137722007879 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 137722007880 hypothetical protein; Validated; Region: PRK00153 137722007881 recombination protein RecR; Reviewed; Region: recR; PRK00076 137722007882 RecR protein; Region: RecR; pfam02132 137722007883 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 137722007884 putative active site [active] 137722007885 putative metal-binding site [ion binding]; other site 137722007886 tetramer interface [polypeptide binding]; other site 137722007887 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 137722007888 active site 137722007889 HIGH motif; other site 137722007890 nucleotide binding site [chemical binding]; other site 137722007891 active site 137722007892 KMSKS motif; other site 137722007893 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 137722007894 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 137722007895 active site 137722007896 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 137722007897 active site 137722007898 metal binding site [ion binding]; metal-binding site 137722007899 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 137722007900 diiron binding motif [ion binding]; other site 137722007901 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 137722007902 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 137722007903 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722007904 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 137722007905 active site 137722007906 Int/Topo IB signature motif; other site 137722007907 DNA binding site [nucleotide binding] 137722007908 DNA binding domain, excisionase family; Region: excise; TIGR01764 137722007909 PIN domain; Region: PIN_3; pfam13470 137722007910 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722007911 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722007912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722007913 Integrase core domain; Region: rve; pfam00665 137722007914 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722007915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722007916 Walker A motif; other site 137722007917 ATP binding site [chemical binding]; other site 137722007918 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722007919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 137722007920 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722007921 Winged helix-turn helix; Region: HTH_29; pfam13551 137722007922 Winged helix-turn helix; Region: HTH_33; pfam13592 137722007923 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 137722007924 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 137722007925 putative MPT binding site; other site 137722007926 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 137722007927 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 137722007928 active site 137722007929 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 137722007930 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 137722007931 structural protein; Region: PHA01972 137722007932 hypothetical protein; Region: PHA00661 137722007933 hypothetical protein; Region: PHA00662 137722007934 hypothetical protein; Region: PHA00670 137722007935 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 137722007936 Phage associated DNA primase [General function prediction only]; Region: COG3378 137722007937 Toprim domain; Region: Toprim_3; pfam13362 137722007938 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722007939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722007940 non-specific DNA binding site [nucleotide binding]; other site 137722007941 salt bridge; other site 137722007942 sequence-specific DNA binding site [nucleotide binding]; other site 137722007943 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 137722007944 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722007945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722007946 non-specific DNA binding site [nucleotide binding]; other site 137722007947 salt bridge; other site 137722007948 sequence-specific DNA binding site [nucleotide binding]; other site 137722007949 ParB-like nuclease domain; Region: ParBc; pfam02195 137722007950 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722007951 active site 137722007952 DNA binding site [nucleotide binding] 137722007953 Int/Topo IB signature motif; other site 137722007954 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 137722007955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 137722007956 ATP binding site [chemical binding]; other site 137722007957 putative Mg++ binding site [ion binding]; other site 137722007958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722007959 nucleotide binding region [chemical binding]; other site 137722007960 ATP-binding site [chemical binding]; other site 137722007961 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 137722007962 HRDC domain; Region: HRDC; pfam00570 137722007963 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 137722007964 active site 137722007965 8-oxo-dGMP binding site [chemical binding]; other site 137722007966 nudix motif; other site 137722007967 metal binding site [ion binding]; metal-binding site 137722007968 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 137722007969 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 137722007970 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 137722007971 heterotetramer interface [polypeptide binding]; other site 137722007972 active site pocket [active] 137722007973 cleavage site 137722007974 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 137722007975 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 137722007976 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 137722007977 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 137722007978 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 137722007979 nucleotide binding region [chemical binding]; other site 137722007980 SEC-C motif; Region: SEC-C; pfam02810 137722007981 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 137722007982 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 137722007983 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722007984 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722007985 substrate binding pocket [chemical binding]; other site 137722007986 membrane-bound complex binding site; other site 137722007987 hinge residues; other site 137722007988 PAS domain S-box; Region: sensory_box; TIGR00229 137722007989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722007990 putative active site [active] 137722007991 heme pocket [chemical binding]; other site 137722007992 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722007993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722007994 metal binding site [ion binding]; metal-binding site 137722007995 active site 137722007996 I-site; other site 137722007997 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722007998 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 137722007999 putative hydrophobic ligand binding site [chemical binding]; other site 137722008000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722008001 dimerization interface [polypeptide binding]; other site 137722008002 putative DNA binding site [nucleotide binding]; other site 137722008003 putative Zn2+ binding site [ion binding]; other site 137722008004 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 137722008005 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 137722008006 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 137722008007 active site 137722008008 nucleotide binding site [chemical binding]; other site 137722008009 HIGH motif; other site 137722008010 KMSKS motif; other site 137722008011 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 137722008012 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 137722008013 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 137722008014 malate dehydrogenase; Reviewed; Region: PRK06223 137722008015 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 137722008016 NAD(P) binding site [chemical binding]; other site 137722008017 dimer interface [polypeptide binding]; other site 137722008018 tetramer (dimer of dimers) interface [polypeptide binding]; other site 137722008019 substrate binding site [chemical binding]; other site 137722008020 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 137722008021 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 137722008022 CoA-ligase; Region: Ligase_CoA; pfam00549 137722008023 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 137722008024 CoA binding domain; Region: CoA_binding; pfam02629 137722008025 CoA-ligase; Region: Ligase_CoA; pfam00549 137722008026 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 137722008027 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 137722008028 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 137722008029 TPP-binding site [chemical binding]; other site 137722008030 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 137722008031 dimer interface [polypeptide binding]; other site 137722008032 PYR/PP interface [polypeptide binding]; other site 137722008033 TPP binding site [chemical binding]; other site 137722008034 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 137722008035 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 137722008036 E3 interaction surface; other site 137722008037 lipoyl attachment site [posttranslational modification]; other site 137722008038 e3 binding domain; Region: E3_binding; pfam02817 137722008039 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 137722008040 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 137722008041 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722008042 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722008043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722008044 PAS domain; Region: PAS_9; pfam13426 137722008045 putative active site [active] 137722008046 heme pocket [chemical binding]; other site 137722008047 formyl-coenzyme A transferase; Provisional; Region: PRK05398 137722008048 CoA-transferase family III; Region: CoA_transf_3; pfam02515 137722008049 HRDC domain; Region: HRDC; pfam00570 137722008050 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 137722008051 diiron binding motif [ion binding]; other site 137722008052 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 137722008053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 137722008054 ATP binding site [chemical binding]; other site 137722008055 putative Mg++ binding site [ion binding]; other site 137722008056 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722008057 nucleotide binding region [chemical binding]; other site 137722008058 ATP-binding site [chemical binding]; other site 137722008059 Helicase associated domain (HA2); Region: HA2; pfam04408 137722008060 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 137722008061 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 137722008062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722008063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722008064 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 137722008065 GTP-binding protein LepA; Provisional; Region: PRK05433 137722008066 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 137722008067 G1 box; other site 137722008068 putative GEF interaction site [polypeptide binding]; other site 137722008069 GTP/Mg2+ binding site [chemical binding]; other site 137722008070 Switch I region; other site 137722008071 G2 box; other site 137722008072 G3 box; other site 137722008073 Switch II region; other site 137722008074 G4 box; other site 137722008075 G5 box; other site 137722008076 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 137722008077 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 137722008078 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 137722008079 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 137722008080 active site 137722008081 homodimer interface [polypeptide binding]; other site 137722008082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722008083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722008084 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722008085 dimerization interface [polypeptide binding]; other site 137722008086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722008087 active site 137722008088 phosphorylation site [posttranslational modification] 137722008089 intermolecular recognition site; other site 137722008090 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 137722008091 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 137722008092 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 137722008093 Zn2+ binding site [ion binding]; other site 137722008094 Mg2+ binding site [ion binding]; other site 137722008095 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722008096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722008097 active site 137722008098 phosphorylation site [posttranslational modification] 137722008099 intermolecular recognition site; other site 137722008100 dimerization interface [polypeptide binding]; other site 137722008101 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 137722008102 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 137722008103 putative tRNA-binding site [nucleotide binding]; other site 137722008104 B3/4 domain; Region: B3_4; pfam03483 137722008105 tRNA synthetase B5 domain; Region: B5; smart00874 137722008106 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 137722008107 dimer interface [polypeptide binding]; other site 137722008108 motif 1; other site 137722008109 motif 3; other site 137722008110 motif 2; other site 137722008111 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 137722008112 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 137722008113 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 137722008114 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 137722008115 dimer interface [polypeptide binding]; other site 137722008116 motif 1; other site 137722008117 active site 137722008118 motif 2; other site 137722008119 motif 3; other site 137722008120 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 137722008121 23S rRNA binding site [nucleotide binding]; other site 137722008122 L21 binding site [polypeptide binding]; other site 137722008123 L13 binding site [polypeptide binding]; other site 137722008124 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 137722008125 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 137722008126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722008127 S-adenosylmethionine binding site [chemical binding]; other site 137722008128 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 137722008129 ABC1 family; Region: ABC1; cl17513 137722008130 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 137722008131 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 137722008132 putative ligand binding site [chemical binding]; other site 137722008133 NAD binding site [chemical binding]; other site 137722008134 dimerization interface [polypeptide binding]; other site 137722008135 catalytic site [active] 137722008136 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 137722008137 pseudouridine synthase; Region: TIGR00093 137722008138 active site 137722008139 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 137722008140 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 137722008141 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722008142 active site 137722008143 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 137722008144 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 137722008145 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 137722008146 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 137722008147 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 137722008148 Ligand binding site [chemical binding]; other site 137722008149 Electron transfer flavoprotein domain; Region: ETF; pfam01012 137722008150 acyl-CoA synthetase; Validated; Region: PRK08162 137722008151 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 137722008152 acyl-activating enzyme (AAE) consensus motif; other site 137722008153 putative active site [active] 137722008154 AMP binding site [chemical binding]; other site 137722008155 putative CoA binding site [chemical binding]; other site 137722008156 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722008157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722008158 active site 137722008159 phosphorylation site [posttranslational modification] 137722008160 intermolecular recognition site; other site 137722008161 dimerization interface [polypeptide binding]; other site 137722008162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722008163 DNA binding site [nucleotide binding] 137722008164 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 137722008165 Cache domain; Region: Cache_2; cl07034 137722008166 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722008167 dimerization interface [polypeptide binding]; other site 137722008168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722008169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722008170 putative active site [active] 137722008171 heme pocket [chemical binding]; other site 137722008172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722008173 dimer interface [polypeptide binding]; other site 137722008174 phosphorylation site [posttranslational modification] 137722008175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722008176 ATP binding site [chemical binding]; other site 137722008177 Mg2+ binding site [ion binding]; other site 137722008178 G-X-G motif; other site 137722008179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722008180 Response regulator receiver domain; Region: Response_reg; pfam00072 137722008181 active site 137722008182 phosphorylation site [posttranslational modification] 137722008183 intermolecular recognition site; other site 137722008184 dimerization interface [polypeptide binding]; other site 137722008185 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 137722008186 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 137722008187 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 137722008188 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722008189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722008190 putative active site [active] 137722008191 heme pocket [chemical binding]; other site 137722008192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722008193 dimer interface [polypeptide binding]; other site 137722008194 phosphorylation site [posttranslational modification] 137722008195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722008196 ATP binding site [chemical binding]; other site 137722008197 Mg2+ binding site [ion binding]; other site 137722008198 G-X-G motif; other site 137722008199 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 137722008200 metal binding site 2 [ion binding]; metal-binding site 137722008201 putative DNA binding helix; other site 137722008202 metal binding site 1 [ion binding]; metal-binding site 137722008203 dimer interface [polypeptide binding]; other site 137722008204 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 137722008205 FMN binding site [chemical binding]; other site 137722008206 substrate binding site [chemical binding]; other site 137722008207 putative catalytic residue [active] 137722008208 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 137722008209 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 137722008210 putative active site [active] 137722008211 catalytic site [active] 137722008212 putative metal binding site [ion binding]; other site 137722008213 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 137722008214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722008215 FeS/SAM binding site; other site 137722008216 TspO/MBR family; Region: TspO_MBR; cl01379 137722008217 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 137722008218 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 137722008219 Lipopolysaccharide-assembly; Region: LptE; cl01125 137722008220 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 137722008221 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 137722008222 HIGH motif; other site 137722008223 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 137722008224 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 137722008225 active site 137722008226 KMSKS motif; other site 137722008227 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 137722008228 tRNA binding surface [nucleotide binding]; other site 137722008229 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 137722008230 Gram-negative porin; Region: Porin_4; pfam13609 137722008231 Gram-negative porin; Region: Porin_4; pfam13609 137722008232 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 137722008233 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 137722008234 catalytic residue [active] 137722008235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 137722008236 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 137722008237 dimerization interface [polypeptide binding]; other site 137722008238 active site 137722008239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722008240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722008241 active site 137722008242 phosphorylation site [posttranslational modification] 137722008243 intermolecular recognition site; other site 137722008244 dimerization interface [polypeptide binding]; other site 137722008245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722008246 DNA binding site [nucleotide binding] 137722008247 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 137722008248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 137722008249 Peptidase M15; Region: Peptidase_M15_3; cl01194 137722008250 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 137722008251 putative catalytic site [active] 137722008252 putative phosphate binding site [ion binding]; other site 137722008253 active site 137722008254 metal binding site A [ion binding]; metal-binding site 137722008255 DNA binding site [nucleotide binding] 137722008256 putative AP binding site [nucleotide binding]; other site 137722008257 putative metal binding site B [ion binding]; other site 137722008258 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 137722008259 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 137722008260 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722008261 MarR family; Region: MarR; pfam01047 137722008262 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 137722008263 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 137722008264 Walker A/P-loop; other site 137722008265 ATP binding site [chemical binding]; other site 137722008266 Q-loop/lid; other site 137722008267 ABC transporter signature motif; other site 137722008268 Walker B; other site 137722008269 D-loop; other site 137722008270 H-loop/switch region; other site 137722008271 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 137722008272 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 137722008273 ABC-ATPase subunit interface; other site 137722008274 dimer interface [polypeptide binding]; other site 137722008275 putative PBP binding regions; other site 137722008276 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 137722008277 intersubunit interface [polypeptide binding]; other site 137722008278 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 137722008279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722008280 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 137722008281 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 137722008282 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 137722008283 catalytic site [active] 137722008284 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 137722008285 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 137722008286 putative ADP-binding pocket [chemical binding]; other site 137722008287 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722008288 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 137722008289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722008290 active site 137722008291 motif I; other site 137722008292 motif II; other site 137722008293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722008294 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 137722008295 Bacterial SH3 domain; Region: SH3_3; pfam08239 137722008296 Bacterial SH3 domain; Region: SH3_3; pfam08239 137722008297 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 137722008298 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 137722008299 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 137722008300 homotetramer interface [polypeptide binding]; other site 137722008301 ligand binding site [chemical binding]; other site 137722008302 catalytic site [active] 137722008303 NAD binding site [chemical binding]; other site 137722008304 Radical SAM superfamily; Region: Radical_SAM; pfam04055 137722008305 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722008306 FeS/SAM binding site; other site 137722008307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722008308 TPR motif; other site 137722008309 binding surface 137722008310 Tetratricopeptide repeat; Region: TPR_12; pfam13424 137722008311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722008312 binding surface 137722008313 TPR motif; other site 137722008314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 137722008315 Tetratricopeptide repeat; Region: TPR_16; pfam13432 137722008316 binding surface 137722008317 TPR motif; other site 137722008318 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 137722008319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722008320 S-adenosylmethionine binding site [chemical binding]; other site 137722008321 active site 137722008322 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 137722008323 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722008324 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722008325 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722008326 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722008327 type VI secretion-associated protein, BMA_A0400 family; Region: VI_minor_4; TIGR03373 137722008328 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 137722008329 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 137722008330 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 137722008331 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 137722008332 ligand binding site [chemical binding]; other site 137722008333 Transglycosylase; Region: Transgly; pfam00912 137722008334 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 137722008335 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 137722008336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722008337 dimer interface [polypeptide binding]; other site 137722008338 phosphorylation site [posttranslational modification] 137722008339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722008340 ATP binding site [chemical binding]; other site 137722008341 Mg2+ binding site [ion binding]; other site 137722008342 G-X-G motif; other site 137722008343 osmolarity response regulator; Provisional; Region: ompR; PRK09468 137722008344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722008345 active site 137722008346 phosphorylation site [posttranslational modification] 137722008347 intermolecular recognition site; other site 137722008348 dimerization interface [polypeptide binding]; other site 137722008349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722008350 DNA binding site [nucleotide binding] 137722008351 LTXXQ motif family protein; Region: LTXXQ; pfam07813 137722008352 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722008353 nucleotide binding region [chemical binding]; other site 137722008354 ATP-binding site [chemical binding]; other site 137722008355 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 137722008356 RNA binding surface [nucleotide binding]; other site 137722008357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 137722008358 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722008359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722008360 Walker A/P-loop; other site 137722008361 ATP binding site [chemical binding]; other site 137722008362 Q-loop/lid; other site 137722008363 ABC transporter signature motif; other site 137722008364 Walker B; other site 137722008365 D-loop; other site 137722008366 H-loop/switch region; other site 137722008367 TOBE domain; Region: TOBE_2; pfam08402 137722008368 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 137722008369 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 137722008370 DnaA N-terminal domain; Region: DnaA_N; pfam11638 137722008371 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 137722008372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722008373 Walker A motif; other site 137722008374 ATP binding site [chemical binding]; other site 137722008375 Walker B motif; other site 137722008376 arginine finger; other site 137722008377 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 137722008378 DnaA box-binding interface [nucleotide binding]; other site 137722008379 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 137722008380 enoyl-CoA hydratase; Provisional; Region: PRK05862 137722008381 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722008382 substrate binding site [chemical binding]; other site 137722008383 oxyanion hole (OAH) forming residues; other site 137722008384 trimer interface [polypeptide binding]; other site 137722008385 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 137722008386 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 137722008387 DNA binding site [nucleotide binding] 137722008388 catalytic residue [active] 137722008389 H2TH interface [polypeptide binding]; other site 137722008390 putative catalytic residues [active] 137722008391 turnover-facilitating residue; other site 137722008392 intercalation triad [nucleotide binding]; other site 137722008393 8OG recognition residue [nucleotide binding]; other site 137722008394 putative reading head residues; other site 137722008395 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 137722008396 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 137722008397 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 137722008398 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 137722008399 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 137722008400 FAD binding pocket [chemical binding]; other site 137722008401 FAD binding motif [chemical binding]; other site 137722008402 phosphate binding motif [ion binding]; other site 137722008403 NAD binding pocket [chemical binding]; other site 137722008404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722008405 putative substrate translocation pore; other site 137722008406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722008407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722008408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722008409 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 137722008410 putative substrate binding pocket [chemical binding]; other site 137722008411 putative dimerization interface [polypeptide binding]; other site 137722008412 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 137722008413 dimerization interface [polypeptide binding]; other site 137722008414 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722008415 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 137722008416 dimer interface [polypeptide binding]; other site 137722008417 putative CheW interface [polypeptide binding]; other site 137722008418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 137722008419 active site 137722008420 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 137722008421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722008422 dimer interface [polypeptide binding]; other site 137722008423 ABC-ATPase subunit interface; other site 137722008424 putative PBP binding loops; other site 137722008425 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 137722008426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 137722008427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722008428 dimer interface [polypeptide binding]; other site 137722008429 conserved gate region; other site 137722008430 putative PBP binding loops; other site 137722008431 ABC-ATPase subunit interface; other site 137722008432 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 137722008433 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 137722008434 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 137722008435 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 137722008436 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 137722008437 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 137722008438 dimer interface [polypeptide binding]; other site 137722008439 substrate binding site [chemical binding]; other site 137722008440 metal binding sites [ion binding]; metal-binding site 137722008441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722008442 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 137722008443 NAD(P) binding site [chemical binding]; other site 137722008444 active site 137722008445 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722008446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722008447 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722008448 dimerization interface [polypeptide binding]; other site 137722008449 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 137722008450 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 137722008451 NAD(P) binding site [chemical binding]; other site 137722008452 LDH/MDH dimer interface [polypeptide binding]; other site 137722008453 substrate binding site [chemical binding]; other site 137722008454 DoxX; Region: DoxX; pfam07681 137722008455 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 137722008456 CoA binding domain; Region: CoA_binding_2; pfam13380 137722008457 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 137722008458 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 137722008459 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 137722008460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722008461 Coenzyme A binding pocket [chemical binding]; other site 137722008462 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 137722008463 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 137722008464 active site 137722008465 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 137722008466 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 137722008467 Cl binding site [ion binding]; other site 137722008468 oligomer interface [polypeptide binding]; other site 137722008469 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 137722008470 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 137722008471 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 137722008472 homodimer interface [polypeptide binding]; other site 137722008473 NADP binding site [chemical binding]; other site 137722008474 substrate binding site [chemical binding]; other site 137722008475 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 137722008476 YGGT family; Region: YGGT; pfam02325 137722008477 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722008478 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722008479 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722008480 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722008481 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722008482 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722008483 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722008484 Winged helix-turn helix; Region: HTH_29; pfam13551 137722008485 Winged helix-turn helix; Region: HTH_33; pfam13592 137722008486 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722008487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 137722008488 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722008489 Int/Topo IB signature motif; other site 137722008490 DNA binding site [nucleotide binding] 137722008491 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 137722008492 Mrr N-terminal domain; Region: Mrr_N; pfam14338 137722008493 Restriction endonuclease; Region: Mrr_cat; pfam04471 137722008494 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 137722008495 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 137722008496 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 137722008497 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 137722008498 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 137722008499 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 137722008500 substrate binding site [chemical binding]; other site 137722008501 active site 137722008502 catalytic residues [active] 137722008503 heterodimer interface [polypeptide binding]; other site 137722008504 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 137722008505 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 137722008506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722008507 catalytic residue [active] 137722008508 Response regulator receiver domain; Region: Response_reg; pfam00072 137722008509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722008510 active site 137722008511 phosphorylation site [posttranslational modification] 137722008512 intermolecular recognition site; other site 137722008513 dimerization interface [polypeptide binding]; other site 137722008514 Hpt domain; Region: Hpt; pfam01627 137722008515 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 137722008516 DNA-binding site [nucleotide binding]; DNA binding site 137722008517 RNA-binding motif; other site 137722008518 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 137722008519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722008520 active site 137722008521 phosphorylation site [posttranslational modification] 137722008522 intermolecular recognition site; other site 137722008523 dimerization interface [polypeptide binding]; other site 137722008524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722008525 Walker A motif; other site 137722008526 ATP binding site [chemical binding]; other site 137722008527 Walker B motif; other site 137722008528 arginine finger; other site 137722008529 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722008530 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 137722008531 Flavoprotein; Region: Flavoprotein; pfam02441 137722008532 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 137722008533 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 137722008534 trimer interface [polypeptide binding]; other site 137722008535 active site 137722008536 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722008537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722008538 putative active site [active] 137722008539 heme pocket [chemical binding]; other site 137722008540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722008541 dimer interface [polypeptide binding]; other site 137722008542 phosphorylation site [posttranslational modification] 137722008543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722008544 ATP binding site [chemical binding]; other site 137722008545 Mg2+ binding site [ion binding]; other site 137722008546 G-X-G motif; other site 137722008547 Response regulator receiver domain; Region: Response_reg; pfam00072 137722008548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722008549 active site 137722008550 phosphorylation site [posttranslational modification] 137722008551 intermolecular recognition site; other site 137722008552 dimerization interface [polypeptide binding]; other site 137722008553 PAS fold; Region: PAS_7; pfam12860 137722008554 PAS fold; Region: PAS_7; pfam12860 137722008555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722008556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722008557 dimer interface [polypeptide binding]; other site 137722008558 phosphorylation site [posttranslational modification] 137722008559 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 137722008560 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 137722008561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 137722008562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 137722008563 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 137722008564 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 137722008565 Phosphotransferase enzyme family; Region: APH; pfam01636 137722008566 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 137722008567 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 137722008568 Substrate binding site; other site 137722008569 metal-binding site 137722008570 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 137722008571 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 137722008572 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 137722008573 Family description; Region: UvrD_C_2; pfam13538 137722008574 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 137722008575 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 137722008576 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 137722008577 catalytic residues [active] 137722008578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722008579 TPR motif; other site 137722008580 binding surface 137722008581 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 137722008582 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 137722008583 putative NAD(P) binding site [chemical binding]; other site 137722008584 DNA polymerase III subunit beta; Validated; Region: PRK05643 137722008585 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 137722008586 putative DNA binding surface [nucleotide binding]; other site 137722008587 dimer interface [polypeptide binding]; other site 137722008588 beta-clamp/clamp loader binding surface; other site 137722008589 beta-clamp/translesion DNA polymerase binding surface; other site 137722008590 recombination protein F; Reviewed; Region: recF; PRK00064 137722008591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722008592 Walker A/P-loop; other site 137722008593 ATP binding site [chemical binding]; other site 137722008594 Q-loop/lid; other site 137722008595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722008596 ABC transporter signature motif; other site 137722008597 Walker B; other site 137722008598 D-loop; other site 137722008599 H-loop/switch region; other site 137722008600 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 137722008601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722008602 ATP binding site [chemical binding]; other site 137722008603 Mg2+ binding site [ion binding]; other site 137722008604 G-X-G motif; other site 137722008605 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 137722008606 anchoring element; other site 137722008607 dimer interface [polypeptide binding]; other site 137722008608 ATP binding site [chemical binding]; other site 137722008609 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 137722008610 active site 137722008611 putative metal-binding site [ion binding]; other site 137722008612 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 137722008613 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722008614 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722008615 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722008616 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 137722008617 DNA binding residues [nucleotide binding] 137722008618 dimerization interface [polypeptide binding]; other site 137722008619 amidase; Provisional; Region: PRK06170 137722008620 Amidase; Region: Amidase; cl11426 137722008621 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 137722008622 Transposase; Region: DEDD_Tnp_IS110; pfam01548 137722008623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 137722008624 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 137722008625 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 137722008626 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 137722008627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722008628 Walker A motif; other site 137722008629 ATP binding site [chemical binding]; other site 137722008630 Walker B motif; other site 137722008631 arginine finger; other site 137722008632 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 137722008633 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 137722008634 metal ion-dependent adhesion site (MIDAS); other site 137722008635 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 137722008636 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 137722008637 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 137722008638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 137722008639 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 137722008640 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 137722008641 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 137722008642 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 137722008643 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 137722008644 Transposase; Region: HTH_Tnp_1; cl17663 137722008645 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722008646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722008647 Walker A motif; other site 137722008648 ATP binding site [chemical binding]; other site 137722008649 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722008650 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722008651 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722008652 Integrase core domain; Region: rve; pfam00665 137722008653 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722008654 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 137722008655 catalytic residues [active] 137722008656 Recombinase; Region: Recombinase; pfam07508 137722008657 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 137722008658 Helix-turn-helix domain; Region: HTH_17; pfam12728 137722008659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722008660 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722008661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722008662 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722008663 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722008664 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722008665 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722008666 Recombinase; Region: Recombinase; pfam07508 137722008667 Helix-turn-helix domain; Region: HTH_17; pfam12728 137722008668 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 137722008669 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 137722008670 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722008671 dimerization interface [polypeptide binding]; other site 137722008672 putative DNA binding site [nucleotide binding]; other site 137722008673 putative Zn2+ binding site [ion binding]; other site 137722008674 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 137722008675 Low molecular weight phosphatase family; Region: LMWPc; cd00115 137722008676 active site 137722008677 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 137722008678 ArsC family; Region: ArsC; pfam03960 137722008679 catalytic residues [active] 137722008680 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 137722008681 Sodium Bile acid symporter family; Region: SBF; cl17470 137722008682 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 137722008683 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 137722008684 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 137722008685 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 137722008686 DNA-binding interface [nucleotide binding]; DNA binding site 137722008687 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722008688 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 137722008689 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722008690 Winged helix-turn helix; Region: HTH_29; pfam13551 137722008691 Winged helix-turn helix; Region: HTH_33; pfam13592 137722008692 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722008693 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 137722008694 catalytic residues [active] 137722008695 catalytic nucleophile [active] 137722008696 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 137722008697 Transposase; Region: HTH_Tnp_1; cl17663 137722008698 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722008699 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722008700 Transposase; Region: DEDD_Tnp_IS110; pfam01548 137722008701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 137722008702 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 137722008703 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 137722008704 DNA-binding interface [nucleotide binding]; DNA binding site 137722008705 Methyltransferase domain; Region: Methyltransf_23; pfam13489 137722008706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722008707 S-adenosylmethionine binding site [chemical binding]; other site 137722008708 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 137722008709 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722008710 Transposase domain (DUF772); Region: DUF772; pfam05598 137722008711 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722008712 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 137722008713 Integrase core domain; Region: rve; pfam00665 137722008714 Integrase core domain; Region: rve_3; pfam13683 137722008715 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722008716 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722008717 Integrase core domain; Region: rve; pfam00665 137722008718 Integrase core domain; Region: rve_3; pfam13683 137722008719 Transposase; Region: HTH_Tnp_1; pfam01527 137722008720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722008721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722008722 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722008723 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722008724 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 137722008725 catalytic residues [active] 137722008726 catalytic nucleophile [active] 137722008727 Recombinase; Region: Recombinase; pfam07508 137722008728 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 137722008729 Helix-turn-helix domain; Region: HTH_17; pfam12728 137722008730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722008731 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722008732 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722008733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722008734 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722008735 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722008736 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722008737 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722008738 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722008739 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722008740 Winged helix-turn helix; Region: HTH_29; pfam13551 137722008741 Winged helix-turn helix; Region: HTH_33; pfam13592 137722008742 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722008743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 137722008744 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722008745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722008746 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722008747 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722008748 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722008749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722008750 Integrase core domain; Region: rve; pfam00665 137722008751 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722008752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722008753 Walker A motif; other site 137722008754 ATP binding site [chemical binding]; other site 137722008755 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722008756 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722008757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722008758 Transposase; Region: HTH_Tnp_1; cl17663 137722008759 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 137722008760 Peptidase family M23; Region: Peptidase_M23; pfam01551 137722008761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 137722008762 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 137722008763 flagellar motor protein MotA; Validated; Region: PRK09110 137722008764 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 137722008765 catalytic residues [active] 137722008766 dimer interface [polypeptide binding]; other site 137722008767 heme exporter protein CcmB; Region: ccmB; TIGR01190 137722008768 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 137722008769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722008770 Walker A/P-loop; other site 137722008771 ATP binding site [chemical binding]; other site 137722008772 Q-loop/lid; other site 137722008773 ABC transporter signature motif; other site 137722008774 Walker B; other site 137722008775 D-loop; other site 137722008776 H-loop/switch region; other site 137722008777 putative transporter; Validated; Region: PRK03818 137722008778 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 137722008779 TrkA-C domain; Region: TrkA_C; pfam02080 137722008780 TrkA-C domain; Region: TrkA_C; pfam02080 137722008781 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 137722008782 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 137722008783 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 137722008784 Walker A/P-loop; other site 137722008785 ATP binding site [chemical binding]; other site 137722008786 Q-loop/lid; other site 137722008787 ABC transporter signature motif; other site 137722008788 Walker B; other site 137722008789 D-loop; other site 137722008790 H-loop/switch region; other site 137722008791 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 137722008792 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722008793 substrate binding pocket [chemical binding]; other site 137722008794 membrane-bound complex binding site; other site 137722008795 hinge residues; other site 137722008796 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 137722008797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722008798 dimer interface [polypeptide binding]; other site 137722008799 conserved gate region; other site 137722008800 putative PBP binding loops; other site 137722008801 ABC-ATPase subunit interface; other site 137722008802 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 137722008803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722008804 dimer interface [polypeptide binding]; other site 137722008805 conserved gate region; other site 137722008806 putative PBP binding loops; other site 137722008807 ABC-ATPase subunit interface; other site 137722008808 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 137722008809 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 137722008810 putative ligand binding site [chemical binding]; other site 137722008811 Predicted methyltransferases [General function prediction only]; Region: COG0313 137722008812 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 137722008813 putative SAM binding site [chemical binding]; other site 137722008814 putative homodimer interface [polypeptide binding]; other site 137722008815 hypothetical protein; Reviewed; Region: PRK12497 137722008816 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 137722008817 Tetratricopeptide repeat; Region: TPR_9; pfam13371 137722008818 glutathione synthetase; Provisional; Region: PRK05246 137722008819 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 137722008820 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 137722008821 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722008822 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722008823 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722008824 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 137722008825 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 137722008826 active site 137722008827 HIGH motif; other site 137722008828 dimer interface [polypeptide binding]; other site 137722008829 KMSKS motif; other site 137722008830 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 137722008831 putative substrate binding pocket [chemical binding]; other site 137722008832 AC domain interface; other site 137722008833 catalytic triad [active] 137722008834 AB domain interface; other site 137722008835 interchain disulfide; other site 137722008836 MarR family; Region: MarR_2; pfam12802 137722008837 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722008838 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722008839 dimer interface [polypeptide binding]; other site 137722008840 putative CheW interface [polypeptide binding]; other site 137722008841 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 137722008842 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 137722008843 N-terminal plug; other site 137722008844 ligand-binding site [chemical binding]; other site 137722008845 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 137722008846 TAP-like protein; Region: Abhydrolase_4; pfam08386 137722008847 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 137722008848 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 137722008849 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 137722008850 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 137722008851 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 137722008852 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 137722008853 Creatinine amidohydrolase; Region: Creatininase; pfam02633 137722008854 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 137722008855 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 137722008856 GrpE; Region: GrpE; pfam01025 137722008857 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 137722008858 dimer interface [polypeptide binding]; other site 137722008859 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 137722008860 Response regulator receiver domain; Region: Response_reg; pfam00072 137722008861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722008862 active site 137722008863 phosphorylation site [posttranslational modification] 137722008864 intermolecular recognition site; other site 137722008865 dimerization interface [polypeptide binding]; other site 137722008866 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 137722008867 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 137722008868 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 137722008869 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 137722008870 Ligand Binding Site [chemical binding]; other site 137722008871 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 137722008872 Predicted permeases [General function prediction only]; Region: COG0730 137722008873 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 137722008874 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 137722008875 adenosine kinase; Provisional; Region: PTZ00247 137722008876 substrate binding site [chemical binding]; other site 137722008877 ATP binding site [chemical binding]; other site 137722008878 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 137722008879 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 137722008880 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 137722008881 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 137722008882 minor groove reading motif; other site 137722008883 helix-hairpin-helix signature motif; other site 137722008884 substrate binding pocket [chemical binding]; other site 137722008885 active site 137722008886 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 137722008887 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 137722008888 Low affinity iron permease; Region: Iron_permease; pfam04120 137722008889 putative mechanosensitive channel protein; Provisional; Region: PRK11465 137722008890 Mechanosensitive ion channel; Region: MS_channel; pfam00924 137722008891 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 137722008892 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 137722008893 Moco binding site; other site 137722008894 metal coordination site [ion binding]; other site 137722008895 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 137722008896 putative deacylase active site [active] 137722008897 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 137722008898 GTP cyclohydrolase I; Provisional; Region: PLN03044 137722008899 active site 137722008900 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 137722008901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722008902 Coenzyme A binding pocket [chemical binding]; other site 137722008903 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 137722008904 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 137722008905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722008906 FeS/SAM binding site; other site 137722008907 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 137722008908 PhoH-like protein; Region: PhoH; pfam02562 137722008909 metal-binding heat shock protein; Provisional; Region: PRK00016 137722008910 FOG: CBS domain [General function prediction only]; Region: COG0517 137722008911 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 137722008912 Transporter associated domain; Region: CorC_HlyC; smart01091 137722008913 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 137722008914 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 137722008915 putative active site [active] 137722008916 catalytic triad [active] 137722008917 putative dimer interface [polypeptide binding]; other site 137722008918 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722008919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722008920 non-specific DNA binding site [nucleotide binding]; other site 137722008921 salt bridge; other site 137722008922 sequence-specific DNA binding site [nucleotide binding]; other site 137722008923 S-adenosylmethionine synthetase; Validated; Region: PRK05250 137722008924 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 137722008925 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 137722008926 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 137722008927 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 137722008928 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 137722008929 ribosome maturation protein RimP; Reviewed; Region: PRK00092 137722008930 Sm and related proteins; Region: Sm_like; cl00259 137722008931 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 137722008932 putative oligomer interface [polypeptide binding]; other site 137722008933 putative RNA binding site [nucleotide binding]; other site 137722008934 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 137722008935 NusA N-terminal domain; Region: NusA_N; pfam08529 137722008936 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 137722008937 RNA binding site [nucleotide binding]; other site 137722008938 homodimer interface [polypeptide binding]; other site 137722008939 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 137722008940 G-X-X-G motif; other site 137722008941 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 137722008942 G-X-X-G motif; other site 137722008943 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 137722008944 hypothetical protein; Provisional; Region: PRK09190 137722008945 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 137722008946 putative RNA binding cleft [nucleotide binding]; other site 137722008947 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 137722008948 translation initiation factor IF-2; Region: IF-2; TIGR00487 137722008949 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 137722008950 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 137722008951 G1 box; other site 137722008952 putative GEF interaction site [polypeptide binding]; other site 137722008953 GTP/Mg2+ binding site [chemical binding]; other site 137722008954 Switch I region; other site 137722008955 G2 box; other site 137722008956 G3 box; other site 137722008957 Switch II region; other site 137722008958 G4 box; other site 137722008959 G5 box; other site 137722008960 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 137722008961 Translation-initiation factor 2; Region: IF-2; pfam11987 137722008962 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 137722008963 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 137722008964 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 137722008965 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 137722008966 RNA binding site [nucleotide binding]; other site 137722008967 active site 137722008968 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 137722008969 16S/18S rRNA binding site [nucleotide binding]; other site 137722008970 S13e-L30e interaction site [polypeptide binding]; other site 137722008971 25S rRNA binding site [nucleotide binding]; other site 137722008972 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 137722008973 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 137722008974 RNase E interface [polypeptide binding]; other site 137722008975 trimer interface [polypeptide binding]; other site 137722008976 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 137722008977 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 137722008978 RNase E interface [polypeptide binding]; other site 137722008979 trimer interface [polypeptide binding]; other site 137722008980 active site 137722008981 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 137722008982 putative nucleic acid binding region [nucleotide binding]; other site 137722008983 G-X-X-G motif; other site 137722008984 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 137722008985 RNA binding site [nucleotide binding]; other site 137722008986 domain interface; other site 137722008987 WYL domain; Region: WYL; pfam13280 137722008988 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 137722008989 putative dimer interface [polypeptide binding]; other site 137722008990 heme exporter protein CcmC; Region: ccmC; TIGR01191 137722008991 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 137722008992 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 137722008993 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 137722008994 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 137722008995 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 137722008996 catalytic residues [active] 137722008997 central insert; other site 137722008998 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 137722008999 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 137722009000 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 137722009001 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 137722009002 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 137722009003 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 137722009004 shikimate binding site; other site 137722009005 NAD(P) binding site [chemical binding]; other site 137722009006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 137722009007 Smr domain; Region: Smr; pfam01713 137722009008 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722009009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722009010 non-specific DNA binding site [nucleotide binding]; other site 137722009011 salt bridge; other site 137722009012 sequence-specific DNA binding site [nucleotide binding]; other site 137722009013 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 137722009014 nucleotide binding site/active site [active] 137722009015 HIT family signature motif; other site 137722009016 catalytic residue [active] 137722009017 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 137722009018 metal binding site [ion binding]; metal-binding site 137722009019 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 137722009020 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 137722009021 substrate binding site [chemical binding]; other site 137722009022 glutamase interaction surface [polypeptide binding]; other site 137722009023 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 137722009024 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 137722009025 catalytic residues [active] 137722009026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722009027 Coenzyme A binding pocket [chemical binding]; other site 137722009028 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 137722009029 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 137722009030 putative active site [active] 137722009031 oxyanion strand; other site 137722009032 catalytic triad [active] 137722009033 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 137722009034 putative active site pocket [active] 137722009035 4-fold oligomerization interface [polypeptide binding]; other site 137722009036 metal binding residues [ion binding]; metal-binding site 137722009037 3-fold/trimer interface [polypeptide binding]; other site 137722009038 Equine arteritis virus serine endopeptidase S32; Region: Peptidase_S32; pfam05579 137722009039 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 137722009040 active site 137722009041 HslU subunit interaction site [polypeptide binding]; other site 137722009042 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 137722009043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722009044 Walker A motif; other site 137722009045 ATP binding site [chemical binding]; other site 137722009046 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 137722009047 Walker B motif; other site 137722009048 arginine finger; other site 137722009049 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 137722009050 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 137722009051 MltA specific insert domain; Region: MltA; smart00925 137722009052 3D domain; Region: 3D; pfam06725 137722009053 Tim44-like domain; Region: Tim44; pfam04280 137722009054 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 137722009055 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 137722009056 SecA binding site; other site 137722009057 Preprotein binding site; other site 137722009058 transcription termination factor Rho; Provisional; Region: rho; PRK09376 137722009059 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 137722009060 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 137722009061 RNA binding site [nucleotide binding]; other site 137722009062 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 137722009063 multimer interface [polypeptide binding]; other site 137722009064 Walker A motif; other site 137722009065 ATP binding site [chemical binding]; other site 137722009066 Walker B motif; other site 137722009067 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 137722009068 ferrochelatase; Reviewed; Region: hemH; PRK00035 137722009069 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 137722009070 C-terminal domain interface [polypeptide binding]; other site 137722009071 active site 137722009072 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 137722009073 active site 137722009074 N-terminal domain interface [polypeptide binding]; other site 137722009075 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 137722009076 substrate binding site [chemical binding]; other site 137722009077 active site 137722009078 Helix-turn-helix domain; Region: HTH_36; pfam13730 137722009079 Replication initiator protein A; Region: RPA; cl17860 137722009080 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722009081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722009082 non-specific DNA binding site [nucleotide binding]; other site 137722009083 salt bridge; other site 137722009084 sequence-specific DNA binding site [nucleotide binding]; other site 137722009085 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 137722009086 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722009087 P-loop; other site 137722009088 Magnesium ion binding site [ion binding]; other site 137722009089 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722009090 Magnesium ion binding site [ion binding]; other site 137722009091 ParB-like nuclease domain; Region: ParB; smart00470 137722009092 KorB domain; Region: KorB; pfam08535 137722009093 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 137722009094 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 137722009095 Uncharacterized conserved protein [Function unknown]; Region: COG4278 137722009096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722009097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722009098 ATP binding site [chemical binding]; other site 137722009099 G-X-G motif; other site 137722009100 Response regulator receiver domain; Region: Response_reg; pfam00072 137722009101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722009102 active site 137722009103 phosphorylation site [posttranslational modification] 137722009104 intermolecular recognition site; other site 137722009105 dimerization interface [polypeptide binding]; other site 137722009106 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 137722009107 PAS domain; Region: PAS_9; pfam13426 137722009108 PAS domain S-box; Region: sensory_box; TIGR00229 137722009109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722009110 putative active site [active] 137722009111 heme pocket [chemical binding]; other site 137722009112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722009113 dimer interface [polypeptide binding]; other site 137722009114 phosphorylation site [posttranslational modification] 137722009115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722009116 ATP binding site [chemical binding]; other site 137722009117 Mg2+ binding site [ion binding]; other site 137722009118 G-X-G motif; other site 137722009119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722009120 active site 137722009121 phosphorylation site [posttranslational modification] 137722009122 intermolecular recognition site; other site 137722009123 dimerization interface [polypeptide binding]; other site 137722009124 Response regulator receiver domain; Region: Response_reg; pfam00072 137722009125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722009126 active site 137722009127 phosphorylation site [posttranslational modification] 137722009128 intermolecular recognition site; other site 137722009129 dimerization interface [polypeptide binding]; other site 137722009130 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 137722009131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722009132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722009133 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722009134 dimerization interface [polypeptide binding]; other site 137722009135 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 137722009136 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722009137 HAMP domain; Region: HAMP; pfam00672 137722009138 dimerization interface [polypeptide binding]; other site 137722009139 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722009140 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722009141 dimer interface [polypeptide binding]; other site 137722009142 putative CheW interface [polypeptide binding]; other site 137722009143 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 137722009144 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 137722009145 putative dimer interface [polypeptide binding]; other site 137722009146 [2Fe-2S] cluster binding site [ion binding]; other site 137722009147 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 137722009148 putative dimer interface [polypeptide binding]; other site 137722009149 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 137722009150 SLBB domain; Region: SLBB; pfam10531 137722009151 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 137722009152 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 137722009153 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722009154 catalytic loop [active] 137722009155 iron binding site [ion binding]; other site 137722009156 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 137722009157 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 137722009158 [4Fe-4S] binding site [ion binding]; other site 137722009159 molybdopterin cofactor binding site; other site 137722009160 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 137722009161 molybdopterin cofactor binding site; other site 137722009162 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 137722009163 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 137722009164 Methyltransferase domain; Region: Methyltransf_31; pfam13847 137722009165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722009166 S-adenosylmethionine binding site [chemical binding]; other site 137722009167 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 137722009168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 137722009169 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 137722009170 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 137722009171 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 137722009172 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 137722009173 putative ligand binding site [chemical binding]; other site 137722009174 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722009175 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722009176 TM-ABC transporter signature motif; other site 137722009177 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 137722009178 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 137722009179 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722009180 TM-ABC transporter signature motif; other site 137722009181 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 137722009182 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722009183 Walker A/P-loop; other site 137722009184 ATP binding site [chemical binding]; other site 137722009185 Q-loop/lid; other site 137722009186 ABC transporter signature motif; other site 137722009187 Walker B; other site 137722009188 D-loop; other site 137722009189 H-loop/switch region; other site 137722009190 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 137722009191 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722009192 Walker A/P-loop; other site 137722009193 ATP binding site [chemical binding]; other site 137722009194 Q-loop/lid; other site 137722009195 ABC transporter signature motif; other site 137722009196 Walker B; other site 137722009197 D-loop; other site 137722009198 H-loop/switch region; other site 137722009199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722009200 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722009201 substrate binding pocket [chemical binding]; other site 137722009202 membrane-bound complex binding site; other site 137722009203 hinge residues; other site 137722009204 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 137722009205 CoenzymeA binding site [chemical binding]; other site 137722009206 subunit interaction site [polypeptide binding]; other site 137722009207 PHB binding site; other site 137722009208 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 137722009209 23S rRNA interface [nucleotide binding]; other site 137722009210 L3 interface [polypeptide binding]; other site 137722009211 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 137722009212 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 137722009213 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 137722009214 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 137722009215 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 137722009216 trimer interface [polypeptide binding]; other site 137722009217 putative metal binding site [ion binding]; other site 137722009218 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 137722009219 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 137722009220 ligand binding site [chemical binding]; other site 137722009221 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 137722009222 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 137722009223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722009224 DNA-binding site [nucleotide binding]; DNA binding site 137722009225 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722009226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722009227 homodimer interface [polypeptide binding]; other site 137722009228 catalytic residue [active] 137722009229 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 137722009230 active site 137722009231 trehalose synthase; Region: treS_nterm; TIGR02456 137722009232 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 137722009233 active site 137722009234 catalytic site [active] 137722009235 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 137722009236 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 137722009237 glycogen branching enzyme; Provisional; Region: PRK05402 137722009238 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 137722009239 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 137722009240 active site 137722009241 catalytic site [active] 137722009242 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 137722009243 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 137722009244 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 137722009245 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 137722009246 active site 137722009247 catalytic site [active] 137722009248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722009249 active site 137722009250 phosphorylation site [posttranslational modification] 137722009251 dimerization interface [polypeptide binding]; other site 137722009252 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 137722009253 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 137722009254 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722009255 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722009256 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 137722009257 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722009258 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722009259 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722009260 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 137722009261 active site 137722009262 DNA binding site [nucleotide binding] 137722009263 Int/Topo IB signature motif; other site 137722009264 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722009265 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722009266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722009267 sequence-specific DNA binding site [nucleotide binding]; other site 137722009268 salt bridge; other site 137722009269 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 137722009270 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 137722009271 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 137722009272 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 137722009273 active site residue [active] 137722009274 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 137722009275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 137722009276 Transposase; Region: DDE_Tnp_ISL3; pfam01610 137722009277 Homeodomain-like domain; Region: HTH_23; pfam13384 137722009278 Transposase; Region: DDE_Tnp_ISL3; pfam01610 137722009279 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 137722009280 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 137722009281 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722009282 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 137722009283 active site 137722009284 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 137722009285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009286 dimer interface [polypeptide binding]; other site 137722009287 conserved gate region; other site 137722009288 putative PBP binding loops; other site 137722009289 ABC-ATPase subunit interface; other site 137722009290 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 137722009291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009292 dimer interface [polypeptide binding]; other site 137722009293 conserved gate region; other site 137722009294 putative PBP binding loops; other site 137722009295 ABC-ATPase subunit interface; other site 137722009296 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 137722009297 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722009298 Walker A/P-loop; other site 137722009299 ATP binding site [chemical binding]; other site 137722009300 Q-loop/lid; other site 137722009301 ABC transporter signature motif; other site 137722009302 Walker B; other site 137722009303 D-loop; other site 137722009304 H-loop/switch region; other site 137722009305 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722009306 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 137722009307 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722009308 Walker A/P-loop; other site 137722009309 ATP binding site [chemical binding]; other site 137722009310 Q-loop/lid; other site 137722009311 ABC transporter signature motif; other site 137722009312 Walker B; other site 137722009313 D-loop; other site 137722009314 H-loop/switch region; other site 137722009315 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 137722009316 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 137722009317 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 137722009318 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 137722009319 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 137722009320 active site 137722009321 non-prolyl cis peptide bond; other site 137722009322 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 137722009323 active site 137722009324 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 137722009325 dimer interface [polypeptide binding]; other site 137722009326 non-prolyl cis peptide bond; other site 137722009327 insertion regions; other site 137722009328 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 137722009329 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 137722009330 active site 137722009331 non-prolyl cis peptide bond; other site 137722009332 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 137722009333 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 137722009334 active site 137722009335 catalytic tetrad [active] 137722009336 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 137722009337 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 137722009338 ligand binding site [chemical binding]; other site 137722009339 NAD binding site [chemical binding]; other site 137722009340 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 137722009341 threonine synthase; Validated; Region: PRK08197 137722009342 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 137722009343 homodimer interface [polypeptide binding]; other site 137722009344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722009345 catalytic residue [active] 137722009346 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722009347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009348 putative PBP binding loops; other site 137722009349 ABC-ATPase subunit interface; other site 137722009350 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722009351 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722009352 Walker A/P-loop; other site 137722009353 ATP binding site [chemical binding]; other site 137722009354 Q-loop/lid; other site 137722009355 ABC transporter signature motif; other site 137722009356 Walker B; other site 137722009357 D-loop; other site 137722009358 H-loop/switch region; other site 137722009359 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 137722009360 NMT1-like family; Region: NMT1_2; pfam13379 137722009361 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 137722009362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 137722009363 active site 137722009364 motif I; other site 137722009365 motif II; other site 137722009366 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 137722009367 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 137722009368 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 137722009369 active site 137722009370 iron coordination sites [ion binding]; other site 137722009371 substrate binding pocket [chemical binding]; other site 137722009372 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 137722009373 NMT1-like family; Region: NMT1_2; pfam13379 137722009374 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 137722009375 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722009376 acyl-activating enzyme (AAE) consensus motif; other site 137722009377 AMP binding site [chemical binding]; other site 137722009378 active site 137722009379 CoA binding site [chemical binding]; other site 137722009380 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 137722009381 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 137722009382 active site 137722009383 non-prolyl cis peptide bond; other site 137722009384 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 137722009385 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 137722009386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722009387 Walker A/P-loop; other site 137722009388 ATP binding site [chemical binding]; other site 137722009389 Q-loop/lid; other site 137722009390 ABC transporter signature motif; other site 137722009391 Walker B; other site 137722009392 D-loop; other site 137722009393 H-loop/switch region; other site 137722009394 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 137722009395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009396 dimer interface [polypeptide binding]; other site 137722009397 conserved gate region; other site 137722009398 putative PBP binding loops; other site 137722009399 ABC-ATPase subunit interface; other site 137722009400 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 137722009401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009402 dimer interface [polypeptide binding]; other site 137722009403 conserved gate region; other site 137722009404 putative PBP binding loops; other site 137722009405 ABC-ATPase subunit interface; other site 137722009406 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722009407 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722009408 substrate binding pocket [chemical binding]; other site 137722009409 membrane-bound complex binding site; other site 137722009410 hinge residues; other site 137722009411 serine acetyltransferase; Provisional; Region: cysE; PRK11132 137722009412 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 137722009413 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 137722009414 trimer interface [polypeptide binding]; other site 137722009415 active site 137722009416 substrate binding site [chemical binding]; other site 137722009417 CoA binding site [chemical binding]; other site 137722009418 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 137722009419 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 137722009420 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722009421 catalytic residue [active] 137722009422 PAS domain; Region: PAS; smart00091 137722009423 PAS domain; Region: PAS_9; pfam13426 137722009424 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722009425 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722009426 metal binding site [ion binding]; metal-binding site 137722009427 active site 137722009428 I-site; other site 137722009429 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722009430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722009431 non-specific DNA binding site [nucleotide binding]; other site 137722009432 salt bridge; other site 137722009433 sequence-specific DNA binding site [nucleotide binding]; other site 137722009434 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 137722009435 active sites [active] 137722009436 tetramer interface [polypeptide binding]; other site 137722009437 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 137722009438 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 137722009439 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 137722009440 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 137722009441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009442 dimer interface [polypeptide binding]; other site 137722009443 conserved gate region; other site 137722009444 ABC-ATPase subunit interface; other site 137722009445 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 137722009446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009447 dimer interface [polypeptide binding]; other site 137722009448 conserved gate region; other site 137722009449 putative PBP binding loops; other site 137722009450 ABC-ATPase subunit interface; other site 137722009451 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 137722009452 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722009453 Walker A/P-loop; other site 137722009454 ATP binding site [chemical binding]; other site 137722009455 Q-loop/lid; other site 137722009456 ABC transporter signature motif; other site 137722009457 Walker B; other site 137722009458 D-loop; other site 137722009459 H-loop/switch region; other site 137722009460 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722009461 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 137722009462 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722009463 Walker A/P-loop; other site 137722009464 ATP binding site [chemical binding]; other site 137722009465 Q-loop/lid; other site 137722009466 ABC transporter signature motif; other site 137722009467 Walker B; other site 137722009468 D-loop; other site 137722009469 H-loop/switch region; other site 137722009470 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 137722009471 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 137722009472 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 137722009473 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 137722009474 Fatty acid desaturase; Region: FA_desaturase; pfam00487 137722009475 putative di-iron ligands [ion binding]; other site 137722009476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009477 dimer interface [polypeptide binding]; other site 137722009478 conserved gate region; other site 137722009479 putative PBP binding loops; other site 137722009480 ABC-ATPase subunit interface; other site 137722009481 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 137722009482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009483 conserved gate region; other site 137722009484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009485 dimer interface [polypeptide binding]; other site 137722009486 ABC-ATPase subunit interface; other site 137722009487 putative PBP binding loops; other site 137722009488 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 137722009489 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722009490 substrate binding pocket [chemical binding]; other site 137722009491 membrane-bound complex binding site; other site 137722009492 hinge residues; other site 137722009493 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 137722009494 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 137722009495 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 137722009496 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 137722009497 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 137722009498 homodimer interface [polypeptide binding]; other site 137722009499 substrate-cofactor binding pocket; other site 137722009500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722009501 catalytic residue [active] 137722009502 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 137722009503 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722009504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009505 dimer interface [polypeptide binding]; other site 137722009506 conserved gate region; other site 137722009507 putative PBP binding loops; other site 137722009508 ABC-ATPase subunit interface; other site 137722009509 NMT1-like family; Region: NMT1_2; pfam13379 137722009510 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 137722009511 substrate binding pocket [chemical binding]; other site 137722009512 membrane-bound complex binding site; other site 137722009513 hinge residues; other site 137722009514 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722009515 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 137722009516 Walker A/P-loop; other site 137722009517 ATP binding site [chemical binding]; other site 137722009518 Q-loop/lid; other site 137722009519 ABC transporter signature motif; other site 137722009520 Walker B; other site 137722009521 D-loop; other site 137722009522 H-loop/switch region; other site 137722009523 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 137722009524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722009525 DNA-binding site [nucleotide binding]; DNA binding site 137722009526 UTRA domain; Region: UTRA; pfam07702 137722009527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009528 dimer interface [polypeptide binding]; other site 137722009529 conserved gate region; other site 137722009530 ABC-ATPase subunit interface; other site 137722009531 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 137722009532 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 137722009533 Walker A/P-loop; other site 137722009534 ATP binding site [chemical binding]; other site 137722009535 Q-loop/lid; other site 137722009536 ABC transporter signature motif; other site 137722009537 Walker B; other site 137722009538 D-loop; other site 137722009539 H-loop/switch region; other site 137722009540 NIL domain; Region: NIL; cl09633 137722009541 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 137722009542 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 137722009543 OsmC-like protein; Region: OsmC; pfam02566 137722009544 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 137722009545 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 137722009546 hypothetical protein; Provisional; Region: PRK08912 137722009547 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722009548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722009549 homodimer interface [polypeptide binding]; other site 137722009550 catalytic residue [active] 137722009551 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 137722009552 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 137722009553 molybdopterin cofactor binding site [chemical binding]; other site 137722009554 substrate binding site [chemical binding]; other site 137722009555 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 137722009556 molybdopterin cofactor binding site; other site 137722009557 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 137722009558 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722009559 substrate binding pocket [chemical binding]; other site 137722009560 membrane-bound complex binding site; other site 137722009561 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722009562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722009563 Walker A/P-loop; other site 137722009564 ATP binding site [chemical binding]; other site 137722009565 Q-loop/lid; other site 137722009566 ABC transporter signature motif; other site 137722009567 Walker B; other site 137722009568 D-loop; other site 137722009569 H-loop/switch region; other site 137722009570 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722009571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722009572 dimer interface [polypeptide binding]; other site 137722009573 conserved gate region; other site 137722009574 putative PBP binding loops; other site 137722009575 ABC-ATPase subunit interface; other site 137722009576 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 137722009577 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 137722009578 active site 137722009579 non-prolyl cis peptide bond; other site 137722009580 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 137722009581 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722009582 membrane-bound complex binding site; other site 137722009583 Ferredoxin [Energy production and conversion]; Region: COG1146 137722009584 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 137722009585 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 137722009586 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 137722009587 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 137722009588 oligomerisation interface [polypeptide binding]; other site 137722009589 mobile loop; other site 137722009590 roof hairpin; other site 137722009591 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 137722009592 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 137722009593 ring oligomerisation interface [polypeptide binding]; other site 137722009594 ATP/Mg binding site [chemical binding]; other site 137722009595 stacking interactions; other site 137722009596 hinge regions; other site 137722009597 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 137722009598 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems; Region: PBP1_ABC_ligand_binding_like_14; cd06349 137722009599 putative ligand binding site [chemical binding]; other site 137722009600 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 137722009601 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems; Region: PBP1_ABC_ligand_binding_like_14; cd06349 137722009602 putative ligand binding site [chemical binding]; other site 137722009603 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722009604 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722009605 TM-ABC transporter signature motif; other site 137722009606 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 137722009607 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722009608 TM-ABC transporter signature motif; other site 137722009609 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722009610 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722009611 Walker A/P-loop; other site 137722009612 ATP binding site [chemical binding]; other site 137722009613 Q-loop/lid; other site 137722009614 ABC transporter signature motif; other site 137722009615 Walker B; other site 137722009616 D-loop; other site 137722009617 H-loop/switch region; other site 137722009618 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722009619 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722009620 Walker A/P-loop; other site 137722009621 ATP binding site [chemical binding]; other site 137722009622 Q-loop/lid; other site 137722009623 ABC transporter signature motif; other site 137722009624 Walker B; other site 137722009625 D-loop; other site 137722009626 H-loop/switch region; other site 137722009627 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 137722009628 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 137722009629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 137722009630 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 137722009631 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 137722009632 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722009633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 137722009634 Winged helix-turn helix; Region: HTH_33; pfam13592 137722009635 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722009636 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722009637 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722009638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 137722009639 Homeodomain-like domain; Region: HTH_32; pfam13565 137722009640 Integrase core domain; Region: rve; pfam00665 137722009641 Integrase core domain; Region: rve_3; pfam13683 137722009642 Homeodomain-like domain; Region: HTH_23; cl17451 137722009643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722009644 Integrase core domain; Region: rve; pfam00665 137722009645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 137722009646 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 137722009647 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722009648 hypothetical protein; Provisional; Region: PRK07206 137722009649 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 137722009650 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 137722009651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722009652 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722009653 putative substrate translocation pore; other site 137722009654 Response regulator receiver domain; Region: Response_reg; pfam00072 137722009655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722009656 active site 137722009657 phosphorylation site [posttranslational modification] 137722009658 intermolecular recognition site; other site 137722009659 dimerization interface [polypeptide binding]; other site 137722009660 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722009661 Transcriptional regulators [Transcription]; Region: MarR; COG1846 137722009662 putative DNA binding site [nucleotide binding]; other site 137722009663 putative Zn2+ binding site [ion binding]; other site 137722009664 Helix-turn-helix domain; Region: HTH_38; pfam13936 137722009665 hypothetical protein; Provisional; Region: PRK05208 137722009666 Protein of unknown function (DUF796); Region: DUF796; cl01226 137722009667 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 137722009668 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 137722009669 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 137722009670 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 137722009671 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 137722009672 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 137722009673 Sporulation related domain; Region: SPOR; pfam05036 137722009674 Sporulation related domain; Region: SPOR; pfam05036 137722009675 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 137722009676 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722009677 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722009678 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 137722009679 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 137722009680 Protein of unknown function (DUF770); Region: DUF770; cl01402 137722009681 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 137722009682 Protein of unknown function (DUF877); Region: DUF877; pfam05943 137722009683 Protein of unknown function (DUF796); Region: DUF796; cl01226 137722009684 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 137722009685 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 137722009686 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 137722009687 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 137722009688 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 137722009689 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 137722009690 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 137722009691 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 137722009692 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 137722009693 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 137722009694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 137722009695 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 137722009696 chromosome segregation protein; Provisional; Region: PRK03918 137722009697 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722009698 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 137722009699 acyl-activating enzyme (AAE) consensus motif; other site 137722009700 AMP binding site [chemical binding]; other site 137722009701 active site 137722009702 CoA binding site [chemical binding]; other site 137722009703 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722009704 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 137722009705 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 137722009706 Thioesterase domain; Region: Thioesterase; pfam00975 137722009707 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 137722009708 putative FMN binding site [chemical binding]; other site 137722009709 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 137722009710 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 137722009711 active site 2 [active] 137722009712 active site 1 [active] 137722009713 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 137722009714 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 137722009715 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 137722009716 active site 137722009717 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722009718 AMP-binding enzyme; Region: AMP-binding; pfam00501 137722009719 acyl-activating enzyme (AAE) consensus motif; other site 137722009720 active site 137722009721 AMP binding site [chemical binding]; other site 137722009722 CoA binding site [chemical binding]; other site 137722009723 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 137722009724 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 137722009725 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 137722009726 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 137722009727 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 137722009728 active site 137722009729 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 137722009730 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 137722009731 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 137722009732 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 137722009733 Enoylreductase; Region: PKS_ER; smart00829 137722009734 NAD(P) binding site [chemical binding]; other site 137722009735 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 137722009736 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 137722009737 putative NADP binding site [chemical binding]; other site 137722009738 active site 137722009739 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 137722009740 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 137722009741 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 137722009742 active site 137722009743 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 137722009744 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 137722009745 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 137722009746 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 137722009747 Enoylreductase; Region: PKS_ER; smart00829 137722009748 NAD(P) binding site [chemical binding]; other site 137722009749 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 137722009750 putative NADP binding site [chemical binding]; other site 137722009751 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 137722009752 active site 137722009753 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 137722009754 Thioesterase; Region: PKS_TE; smart00824 137722009755 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 137722009756 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 137722009757 active site 137722009758 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 137722009759 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 137722009760 NAD(P) binding site [chemical binding]; other site 137722009761 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 137722009762 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722009763 acyl-activating enzyme (AAE) consensus motif; other site 137722009764 AMP binding site [chemical binding]; other site 137722009765 active site 137722009766 CoA binding site [chemical binding]; other site 137722009767 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 137722009768 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722009769 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722009770 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722009771 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722009772 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722009773 Winged helix-turn helix; Region: HTH_29; pfam13551 137722009774 Winged helix-turn helix; Region: HTH_33; pfam13592 137722009775 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722009776 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722009777 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 137722009778 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 137722009779 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 137722009780 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 137722009781 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 137722009782 Walker A motif; other site 137722009783 ATP binding site [chemical binding]; other site 137722009784 Walker B motif; other site 137722009785 Protein of unknown function, DUF606; Region: DUF606; pfam04657 137722009786 Cupin domain; Region: Cupin_2; pfam07883 137722009787 Helix-turn-helix domain; Region: HTH_18; pfam12833 137722009788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722009789 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 137722009790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722009791 Coenzyme A binding pocket [chemical binding]; other site 137722009792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722009793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722009794 putative substrate translocation pore; other site 137722009795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722009796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722009797 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722009798 dimerization interface [polypeptide binding]; other site 137722009799 PAS fold; Region: PAS_4; pfam08448 137722009800 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722009801 putative active site [active] 137722009802 heme pocket [chemical binding]; other site 137722009803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722009804 PAS domain; Region: PAS_9; pfam13426 137722009805 putative active site [active] 137722009806 heme pocket [chemical binding]; other site 137722009807 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722009808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722009809 dimer interface [polypeptide binding]; other site 137722009810 phosphorylation site [posttranslational modification] 137722009811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722009812 ATP binding site [chemical binding]; other site 137722009813 Mg2+ binding site [ion binding]; other site 137722009814 G-X-G motif; other site 137722009815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722009816 Response regulator receiver domain; Region: Response_reg; pfam00072 137722009817 active site 137722009818 phosphorylation site [posttranslational modification] 137722009819 intermolecular recognition site; other site 137722009820 dimerization interface [polypeptide binding]; other site 137722009821 FCD domain; Region: FCD; pfam07729 137722009822 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 137722009823 active site 137722009824 homopentamer interface [polypeptide binding]; other site 137722009825 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 137722009826 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 137722009827 isovaleryl-CoA dehydrogenase; Region: PLN02519 137722009828 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 137722009829 substrate binding site [chemical binding]; other site 137722009830 FAD binding site [chemical binding]; other site 137722009831 catalytic base [active] 137722009832 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 137722009833 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 137722009834 dimer interface [polypeptide binding]; other site 137722009835 active site 137722009836 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722009837 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 137722009838 FAD binding site [chemical binding]; other site 137722009839 homotetramer interface [polypeptide binding]; other site 137722009840 substrate binding pocket [chemical binding]; other site 137722009841 catalytic base [active] 137722009842 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 137722009843 enoyl-CoA hydratase; Provisional; Region: PRK05995 137722009844 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722009845 substrate binding site [chemical binding]; other site 137722009846 oxyanion hole (OAH) forming residues; other site 137722009847 trimer interface [polypeptide binding]; other site 137722009848 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 137722009849 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 137722009850 ATP-grasp domain; Region: ATP-grasp_4; cl17255 137722009851 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 137722009852 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 137722009853 carboxyltransferase (CT) interaction site; other site 137722009854 biotinylation site [posttranslational modification]; other site 137722009855 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 137722009856 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 137722009857 active site 137722009858 catalytic residues [active] 137722009859 metal binding site [ion binding]; metal-binding site 137722009860 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722009861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722009862 active site 137722009863 phosphorylation site [posttranslational modification] 137722009864 intermolecular recognition site; other site 137722009865 dimerization interface [polypeptide binding]; other site 137722009866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722009867 DNA binding site [nucleotide binding] 137722009868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722009869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 137722009870 phosphorylation site [posttranslational modification] 137722009871 dimer interface [polypeptide binding]; other site 137722009872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722009873 ATP binding site [chemical binding]; other site 137722009874 Mg2+ binding site [ion binding]; other site 137722009875 G-X-G motif; other site 137722009876 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 137722009877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722009878 putative DNA binding site [nucleotide binding]; other site 137722009879 putative Zn2+ binding site [ion binding]; other site 137722009880 AsnC family; Region: AsnC_trans_reg; pfam01037 137722009881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722009882 PAS domain; Region: PAS_9; pfam13426 137722009883 putative active site [active] 137722009884 heme pocket [chemical binding]; other site 137722009885 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722009886 Tar ligand binding domain homologue; Region: TarH; pfam02203 137722009887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722009888 dimerization interface [polypeptide binding]; other site 137722009889 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722009890 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722009891 putative CheW interface [polypeptide binding]; other site 137722009892 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 137722009893 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 137722009894 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 137722009895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722009896 Walker A/P-loop; other site 137722009897 ATP binding site [chemical binding]; other site 137722009898 Q-loop/lid; other site 137722009899 ABC transporter signature motif; other site 137722009900 Walker B; other site 137722009901 D-loop; other site 137722009902 H-loop/switch region; other site 137722009903 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 137722009904 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722009905 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722009906 Cadherin repeat-like domain; Region: CA_like; cl15786 137722009907 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 137722009908 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 137722009909 Family description; Region: VCBS; pfam13517 137722009910 Family description; Region: VCBS; pfam13517 137722009911 Family description; Region: VCBS; pfam13517 137722009912 Family description; Region: VCBS; pfam13517 137722009913 Tetratricopeptide repeat; Region: TPR_16; pfam13432 137722009914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722009915 TPR motif; other site 137722009916 binding surface 137722009917 Tetratricopeptide repeat; Region: TPR_16; pfam13432 137722009918 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722009919 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 137722009920 TM-ABC transporter signature motif; other site 137722009921 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 137722009922 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 137722009923 Walker A/P-loop; other site 137722009924 ATP binding site [chemical binding]; other site 137722009925 Q-loop/lid; other site 137722009926 ABC transporter signature motif; other site 137722009927 Walker B; other site 137722009928 D-loop; other site 137722009929 H-loop/switch region; other site 137722009930 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 137722009931 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 137722009932 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 137722009933 putative ligand binding site [chemical binding]; other site 137722009934 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 137722009935 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 137722009936 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 137722009937 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 137722009938 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 137722009939 ATP-grasp domain; Region: ATP-grasp_4; cl17255 137722009940 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 137722009941 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 137722009942 carboxyltransferase (CT) interaction site; other site 137722009943 biotinylation site [posttranslational modification]; other site 137722009944 hypothetical protein; Provisional; Region: PRK12569 137722009945 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722009946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722009947 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 137722009948 putative substrate binding pocket [chemical binding]; other site 137722009949 dimerization interface [polypeptide binding]; other site 137722009950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722009951 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722009952 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 137722009953 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722009954 AMP-binding enzyme; Region: AMP-binding; pfam00501 137722009955 acyl-activating enzyme (AAE) consensus motif; other site 137722009956 active site 137722009957 AMP binding site [chemical binding]; other site 137722009958 CoA binding site [chemical binding]; other site 137722009959 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722009960 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722009961 Walker A/P-loop; other site 137722009962 ATP binding site [chemical binding]; other site 137722009963 Q-loop/lid; other site 137722009964 ABC transporter signature motif; other site 137722009965 Walker B; other site 137722009966 D-loop; other site 137722009967 H-loop/switch region; other site 137722009968 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 137722009969 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722009970 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 137722009971 acyl-activating enzyme (AAE) consensus motif; other site 137722009972 putative AMP binding site [chemical binding]; other site 137722009973 putative active site [active] 137722009974 putative CoA binding site [chemical binding]; other site 137722009975 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722009976 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722009977 TM-ABC transporter signature motif; other site 137722009978 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 137722009979 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722009980 TM-ABC transporter signature motif; other site 137722009981 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 137722009982 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 137722009983 putative ligand binding site [chemical binding]; other site 137722009984 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722009985 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722009986 Walker A/P-loop; other site 137722009987 ATP binding site [chemical binding]; other site 137722009988 Q-loop/lid; other site 137722009989 ABC transporter signature motif; other site 137722009990 Walker B; other site 137722009991 D-loop; other site 137722009992 H-loop/switch region; other site 137722009993 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 137722009994 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722009995 acyl-activating enzyme (AAE) consensus motif; other site 137722009996 active site 137722009997 AMP binding site [chemical binding]; other site 137722009998 CoA binding site [chemical binding]; other site 137722009999 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 137722010000 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 137722010001 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 137722010002 N-terminal domain interface [polypeptide binding]; other site 137722010003 dimer interface [polypeptide binding]; other site 137722010004 substrate binding pocket (H-site) [chemical binding]; other site 137722010005 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 137722010006 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 137722010007 substrate binding site [chemical binding]; other site 137722010008 activation loop (A-loop); other site 137722010009 PAS fold; Region: PAS_4; pfam08448 137722010010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722010011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722010012 dimer interface [polypeptide binding]; other site 137722010013 phosphorylation site [posttranslational modification] 137722010014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722010015 ATP binding site [chemical binding]; other site 137722010016 Mg2+ binding site [ion binding]; other site 137722010017 G-X-G motif; other site 137722010018 Response regulator receiver domain; Region: Response_reg; pfam00072 137722010019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010020 active site 137722010021 phosphorylation site [posttranslational modification] 137722010022 intermolecular recognition site; other site 137722010023 dimerization interface [polypeptide binding]; other site 137722010024 PAS domain S-box; Region: sensory_box; TIGR00229 137722010025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722010026 putative active site [active] 137722010027 heme pocket [chemical binding]; other site 137722010028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722010029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722010030 dimer interface [polypeptide binding]; other site 137722010031 phosphorylation site [posttranslational modification] 137722010032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722010033 ATP binding site [chemical binding]; other site 137722010034 Mg2+ binding site [ion binding]; other site 137722010035 G-X-G motif; other site 137722010036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010037 Response regulator receiver domain; Region: Response_reg; pfam00072 137722010038 active site 137722010039 phosphorylation site [posttranslational modification] 137722010040 intermolecular recognition site; other site 137722010041 dimerization interface [polypeptide binding]; other site 137722010042 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722010043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010044 active site 137722010045 phosphorylation site [posttranslational modification] 137722010046 intermolecular recognition site; other site 137722010047 dimerization interface [polypeptide binding]; other site 137722010048 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 137722010049 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 137722010050 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 137722010051 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722010052 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722010053 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 137722010054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722010055 Walker A/P-loop; other site 137722010056 ATP binding site [chemical binding]; other site 137722010057 Q-loop/lid; other site 137722010058 ABC transporter signature motif; other site 137722010059 Walker B; other site 137722010060 D-loop; other site 137722010061 H-loop/switch region; other site 137722010062 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 137722010063 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 137722010064 catalytic triad [active] 137722010065 dimer interface [polypeptide binding]; other site 137722010066 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 137722010067 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 137722010068 enolase; Provisional; Region: eno; PRK00077 137722010069 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 137722010070 dimer interface [polypeptide binding]; other site 137722010071 metal binding site [ion binding]; metal-binding site 137722010072 substrate binding pocket [chemical binding]; other site 137722010073 PGAP1-like protein; Region: PGAP1; pfam07819 137722010074 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 137722010075 integral membrane protein MviN; Region: mviN; TIGR01695 137722010076 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 137722010077 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 137722010078 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 137722010079 active site residue [active] 137722010080 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 137722010081 active site residue [active] 137722010082 flagellar motor switch protein FliN; Region: fliN; TIGR02480 137722010083 diaminopropionate ammonia-lyase; Provisional; Region: PRK08206 137722010084 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722010085 catalytic residue [active] 137722010086 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 137722010087 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 137722010088 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 137722010089 GatB domain; Region: GatB_Yqey; smart00845 137722010090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722010091 PAS fold; Region: PAS_3; pfam08447 137722010092 putative active site [active] 137722010093 heme pocket [chemical binding]; other site 137722010094 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722010095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722010096 putative active site [active] 137722010097 heme pocket [chemical binding]; other site 137722010098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722010099 dimer interface [polypeptide binding]; other site 137722010100 phosphorylation site [posttranslational modification] 137722010101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722010102 ATP binding site [chemical binding]; other site 137722010103 Mg2+ binding site [ion binding]; other site 137722010104 G-X-G motif; other site 137722010105 sensor protein PhoQ; Provisional; Region: PRK10815 137722010106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722010107 ATP binding site [chemical binding]; other site 137722010108 Mg2+ binding site [ion binding]; other site 137722010109 G-X-G motif; other site 137722010110 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722010111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010112 active site 137722010113 phosphorylation site [posttranslational modification] 137722010114 intermolecular recognition site; other site 137722010115 dimerization interface [polypeptide binding]; other site 137722010116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722010117 DNA binding site [nucleotide binding] 137722010118 Predicted membrane protein [Function unknown]; Region: COG3212 137722010119 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 137722010120 Dihaem cytochrome c; Region: DHC; pfam09626 137722010121 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 137722010122 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 137722010123 P-loop; other site 137722010124 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 137722010125 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 137722010126 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 137722010127 FHIPEP family; Region: FHIPEP; pfam00771 137722010128 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 137722010129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722010130 Walker A motif; other site 137722010131 ATP binding site [chemical binding]; other site 137722010132 Walker B motif; other site 137722010133 arginine finger; other site 137722010134 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722010135 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 137722010136 flagellar motor switch protein; Reviewed; Region: PRK08916 137722010137 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 137722010138 flagellar assembly protein H; Validated; Region: fliH; PRK06032 137722010139 Flagellar assembly protein FliH; Region: FliH; pfam02108 137722010140 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 137722010141 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 137722010142 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 137722010143 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722010144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722010145 non-specific DNA binding site [nucleotide binding]; other site 137722010146 salt bridge; other site 137722010147 sequence-specific DNA binding site [nucleotide binding]; other site 137722010148 HD domain; Region: HD_3; cl17350 137722010149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722010150 PAS domain; Region: PAS_9; pfam13426 137722010151 putative active site [active] 137722010152 heme pocket [chemical binding]; other site 137722010153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722010154 dimer interface [polypeptide binding]; other site 137722010155 phosphorylation site [posttranslational modification] 137722010156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722010157 ATP binding site [chemical binding]; other site 137722010158 Mg2+ binding site [ion binding]; other site 137722010159 G-X-G motif; other site 137722010160 Response regulator receiver domain; Region: Response_reg; pfam00072 137722010161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010162 active site 137722010163 phosphorylation site [posttranslational modification] 137722010164 intermolecular recognition site; other site 137722010165 dimerization interface [polypeptide binding]; other site 137722010166 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 137722010167 putative binding surface; other site 137722010168 active site 137722010169 Response regulator receiver domain; Region: Response_reg; pfam00072 137722010170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010171 active site 137722010172 phosphorylation site [posttranslational modification] 137722010173 intermolecular recognition site; other site 137722010174 dimerization interface [polypeptide binding]; other site 137722010175 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 137722010176 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 137722010177 Domain of unknown function DUF21; Region: DUF21; pfam01595 137722010178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 137722010179 Transporter associated domain; Region: CorC_HlyC; smart01091 137722010180 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 137722010181 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722010182 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 137722010183 Walker A/P-loop; other site 137722010184 ATP binding site [chemical binding]; other site 137722010185 Q-loop/lid; other site 137722010186 ABC transporter signature motif; other site 137722010187 Walker B; other site 137722010188 D-loop; other site 137722010189 H-loop/switch region; other site 137722010190 TOBE domain; Region: TOBE_2; pfam08402 137722010191 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 137722010192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722010193 dimer interface [polypeptide binding]; other site 137722010194 conserved gate region; other site 137722010195 ABC-ATPase subunit interface; other site 137722010196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722010197 dimer interface [polypeptide binding]; other site 137722010198 conserved gate region; other site 137722010199 putative PBP binding loops; other site 137722010200 ABC-ATPase subunit interface; other site 137722010201 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 137722010202 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 137722010203 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722010204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010205 active site 137722010206 phosphorylation site [posttranslational modification] 137722010207 intermolecular recognition site; other site 137722010208 dimerization interface [polypeptide binding]; other site 137722010209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722010210 DNA binding site [nucleotide binding] 137722010211 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 137722010212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722010213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722010214 dimer interface [polypeptide binding]; other site 137722010215 phosphorylation site [posttranslational modification] 137722010216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722010217 ATP binding site [chemical binding]; other site 137722010218 Mg2+ binding site [ion binding]; other site 137722010219 G-X-G motif; other site 137722010220 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 137722010221 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 137722010222 Mechanosensitive ion channel; Region: MS_channel; pfam00924 137722010223 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722010224 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722010225 ligand binding site [chemical binding]; other site 137722010226 flexible hinge region; other site 137722010227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722010228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722010229 dimer interface [polypeptide binding]; other site 137722010230 phosphorylation site [posttranslational modification] 137722010231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722010232 ATP binding site [chemical binding]; other site 137722010233 Mg2+ binding site [ion binding]; other site 137722010234 G-X-G motif; other site 137722010235 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722010236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010237 active site 137722010238 phosphorylation site [posttranslational modification] 137722010239 intermolecular recognition site; other site 137722010240 dimerization interface [polypeptide binding]; other site 137722010241 Response regulator receiver domain; Region: Response_reg; pfam00072 137722010242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010243 active site 137722010244 phosphorylation site [posttranslational modification] 137722010245 intermolecular recognition site; other site 137722010246 dimerization interface [polypeptide binding]; other site 137722010247 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 137722010248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010249 active site 137722010250 phosphorylation site [posttranslational modification] 137722010251 intermolecular recognition site; other site 137722010252 dimerization interface [polypeptide binding]; other site 137722010253 CheB methylesterase; Region: CheB_methylest; pfam01339 137722010254 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 137722010255 putative binding surface; other site 137722010256 active site 137722010257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722010258 ATP binding site [chemical binding]; other site 137722010259 Mg2+ binding site [ion binding]; other site 137722010260 G-X-G motif; other site 137722010261 CheW-like domain; Region: CheW; pfam01584 137722010262 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722010263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010264 active site 137722010265 phosphorylation site [posttranslational modification] 137722010266 intermolecular recognition site; other site 137722010267 dimerization interface [polypeptide binding]; other site 137722010268 HAMP domain; Region: HAMP; pfam00672 137722010269 dimerization interface [polypeptide binding]; other site 137722010270 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722010271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722010272 dimer interface [polypeptide binding]; other site 137722010273 putative CheW interface [polypeptide binding]; other site 137722010274 CheW-like domain; Region: CheW; pfam01584 137722010275 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 137722010276 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 137722010277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722010278 binding surface 137722010279 TPR motif; other site 137722010280 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 137722010281 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 137722010282 putative active site [active] 137722010283 putative catalytic site [active] 137722010284 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 137722010285 Response regulator receiver domain; Region: Response_reg; pfam00072 137722010286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010287 active site 137722010288 phosphorylation site [posttranslational modification] 137722010289 intermolecular recognition site; other site 137722010290 dimerization interface [polypeptide binding]; other site 137722010291 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722010292 DNA binding residues [nucleotide binding] 137722010293 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 137722010294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722010295 dimer interface [polypeptide binding]; other site 137722010296 phosphorylation site [posttranslational modification] 137722010297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722010298 ATP binding site [chemical binding]; other site 137722010299 Mg2+ binding site [ion binding]; other site 137722010300 G-X-G motif; other site 137722010301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010302 active site 137722010303 phosphorylation site [posttranslational modification] 137722010304 intermolecular recognition site; other site 137722010305 dimerization interface [polypeptide binding]; other site 137722010306 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 137722010307 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 137722010308 phosphate binding site [ion binding]; other site 137722010309 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722010310 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722010311 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722010312 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722010313 phosphoglycolate phosphatase; Provisional; Region: PRK13222 137722010314 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 137722010315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722010316 motif II; other site 137722010317 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 137722010318 pantoate--beta-alanine ligase; Region: panC; TIGR00018 137722010319 Pantoate-beta-alanine ligase; Region: PanC; cd00560 137722010320 active site 137722010321 ATP-binding site [chemical binding]; other site 137722010322 pantoate-binding site; other site 137722010323 HXXH motif; other site 137722010324 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 137722010325 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 137722010326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722010327 putative substrate translocation pore; other site 137722010328 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 137722010329 thiamine phosphate binding site [chemical binding]; other site 137722010330 active site 137722010331 pyrophosphate binding site [ion binding]; other site 137722010332 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722010333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722010334 DNA-binding site [nucleotide binding]; DNA binding site 137722010335 FCD domain; Region: FCD; pfam07729 137722010336 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 137722010337 pyruvate kinase; Provisional; Region: PRK06247 137722010338 domain interfaces; other site 137722010339 active site 137722010340 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 137722010341 nudix motif; other site 137722010342 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 137722010343 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 137722010344 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 137722010345 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 137722010346 putative active site [active] 137722010347 Zn binding site [ion binding]; other site 137722010348 FOG: CBS domain [General function prediction only]; Region: COG0517 137722010349 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 137722010350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722010351 Coenzyme A binding pocket [chemical binding]; other site 137722010352 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 137722010353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722010354 putative substrate translocation pore; other site 137722010355 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 137722010356 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 137722010357 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 137722010358 FOG: CBS domain [General function prediction only]; Region: COG0517 137722010359 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 137722010360 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 137722010361 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 137722010362 ligand binding site [chemical binding]; other site 137722010363 homodimer interface [polypeptide binding]; other site 137722010364 NAD(P) binding site [chemical binding]; other site 137722010365 trimer interface B [polypeptide binding]; other site 137722010366 trimer interface A [polypeptide binding]; other site 137722010367 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 137722010368 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 137722010369 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 137722010370 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 137722010371 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 137722010372 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 137722010373 active site 137722010374 catalytic site [active] 137722010375 tetramer interface [polypeptide binding]; other site 137722010376 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 137722010377 active site 137722010378 homotetramer interface [polypeptide binding]; other site 137722010379 glyoxylate carboligase; Provisional; Region: PRK11269 137722010380 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 137722010381 PYR/PP interface [polypeptide binding]; other site 137722010382 dimer interface [polypeptide binding]; other site 137722010383 TPP binding site [chemical binding]; other site 137722010384 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 137722010385 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 137722010386 TPP-binding site [chemical binding]; other site 137722010387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722010388 dimerization interface [polypeptide binding]; other site 137722010389 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722010390 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722010391 dimer interface [polypeptide binding]; other site 137722010392 putative CheW interface [polypeptide binding]; other site 137722010393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722010394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722010395 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 137722010396 putative effector binding pocket; other site 137722010397 dimerization interface [polypeptide binding]; other site 137722010398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722010399 PAS domain; Region: PAS_9; pfam13426 137722010400 putative active site [active] 137722010401 heme pocket [chemical binding]; other site 137722010402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722010403 PAS domain; Region: PAS_9; pfam13426 137722010404 putative active site [active] 137722010405 heme pocket [chemical binding]; other site 137722010406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722010407 PAS domain; Region: PAS_9; pfam13426 137722010408 putative active site [active] 137722010409 heme pocket [chemical binding]; other site 137722010410 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722010411 dimer interface [polypeptide binding]; other site 137722010412 putative CheW interface [polypeptide binding]; other site 137722010413 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 137722010414 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 137722010415 Bacterial transcriptional regulator; Region: IclR; pfam01614 137722010416 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722010417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722010418 DNA-binding site [nucleotide binding]; DNA binding site 137722010419 FCD domain; Region: FCD; pfam07729 137722010420 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 137722010421 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 137722010422 PYR/PP interface [polypeptide binding]; other site 137722010423 dimer interface [polypeptide binding]; other site 137722010424 TPP binding site [chemical binding]; other site 137722010425 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 137722010426 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 137722010427 TPP-binding site; other site 137722010428 dimer interface [polypeptide binding]; other site 137722010429 formyl-coenzyme A transferase; Provisional; Region: PRK05398 137722010430 CoA-transferase family III; Region: CoA_transf_3; pfam02515 137722010431 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 137722010432 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 137722010433 CoA-ligase; Region: Ligase_CoA; pfam00549 137722010434 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 137722010435 CoA binding domain; Region: CoA_binding; pfam02629 137722010436 CoA-ligase; Region: Ligase_CoA; pfam00549 137722010437 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 137722010438 Transcriptional regulator [Transcription]; Region: IclR; COG1414 137722010439 Bacterial transcriptional regulator; Region: IclR; pfam01614 137722010440 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 137722010441 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 137722010442 NAD(P) binding site [chemical binding]; other site 137722010443 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 137722010444 BON domain; Region: BON; pfam04972 137722010445 BON domain; Region: BON; pfam04972 137722010446 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 137722010447 active site 137722010448 metal binding site [ion binding]; metal-binding site 137722010449 Protein of unknown function (DUF1386); Region: DUF1386; pfam07138 137722010450 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 137722010451 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 137722010452 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 137722010453 putative active site [active] 137722010454 putative substrate binding site [chemical binding]; other site 137722010455 putative cosubstrate binding site; other site 137722010456 catalytic site [active] 137722010457 two-component response regulator; Provisional; Region: PRK09191 137722010458 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 137722010459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010460 active site 137722010461 phosphorylation site [posttranslational modification] 137722010462 intermolecular recognition site; other site 137722010463 dimerization interface [polypeptide binding]; other site 137722010464 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722010465 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 137722010466 acyl-activating enzyme (AAE) consensus motif; other site 137722010467 AMP binding site [chemical binding]; other site 137722010468 active site 137722010469 CoA binding site [chemical binding]; other site 137722010470 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 137722010471 putative active site [active] 137722010472 YdjC motif; other site 137722010473 Mg binding site [ion binding]; other site 137722010474 putative homodimer interface [polypeptide binding]; other site 137722010475 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 137722010476 EamA-like transporter family; Region: EamA; pfam00892 137722010477 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 137722010478 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 137722010479 peptide binding site [polypeptide binding]; other site 137722010480 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 137722010481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722010482 dimer interface [polypeptide binding]; other site 137722010483 conserved gate region; other site 137722010484 putative PBP binding loops; other site 137722010485 ABC-ATPase subunit interface; other site 137722010486 dipeptide transporter; Provisional; Region: PRK10913 137722010487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722010488 putative PBP binding loops; other site 137722010489 dimer interface [polypeptide binding]; other site 137722010490 ABC-ATPase subunit interface; other site 137722010491 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 137722010492 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722010493 Walker A/P-loop; other site 137722010494 ATP binding site [chemical binding]; other site 137722010495 Q-loop/lid; other site 137722010496 ABC transporter signature motif; other site 137722010497 Walker B; other site 137722010498 D-loop; other site 137722010499 H-loop/switch region; other site 137722010500 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722010501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722010502 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 137722010503 Walker A/P-loop; other site 137722010504 ATP binding site [chemical binding]; other site 137722010505 Q-loop/lid; other site 137722010506 ABC transporter signature motif; other site 137722010507 Walker B; other site 137722010508 D-loop; other site 137722010509 H-loop/switch region; other site 137722010510 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722010511 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 137722010512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 137722010513 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 137722010514 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 137722010515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722010516 putative substrate translocation pore; other site 137722010517 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 137722010518 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 137722010519 tandem repeat interface [polypeptide binding]; other site 137722010520 oligomer interface [polypeptide binding]; other site 137722010521 active site residues [active] 137722010522 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 137722010523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 137722010524 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 137722010525 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 137722010526 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 137722010527 substrate binding pocket [chemical binding]; other site 137722010528 chain length determination region; other site 137722010529 substrate-Mg2+ binding site; other site 137722010530 catalytic residues [active] 137722010531 aspartate-rich region 1; other site 137722010532 active site lid residues [active] 137722010533 aspartate-rich region 2; other site 137722010534 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 137722010535 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 137722010536 active site 137722010537 metal binding site [ion binding]; metal-binding site 137722010538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722010539 binding surface 137722010540 TPR motif; other site 137722010541 TPR repeat; Region: TPR_11; pfam13414 137722010542 TPR repeat; Region: TPR_11; pfam13414 137722010543 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 137722010544 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 137722010545 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 137722010546 Predicted membrane protein [Function unknown]; Region: COG2860 137722010547 UPF0126 domain; Region: UPF0126; pfam03458 137722010548 UPF0126 domain; Region: UPF0126; pfam03458 137722010549 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 137722010550 metal-binding site [ion binding] 137722010551 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 137722010552 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 137722010553 metal-binding site [ion binding] 137722010554 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 137722010555 Soluble P-type ATPase [General function prediction only]; Region: COG4087 137722010556 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 137722010557 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 137722010558 DNA binding residues [nucleotide binding] 137722010559 dimer interface [polypeptide binding]; other site 137722010560 copper binding site [ion binding]; other site 137722010561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722010562 putative substrate translocation pore; other site 137722010563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722010564 PRC-barrel domain; Region: PRC; pfam05239 137722010565 Methyltransferase domain; Region: Methyltransf_23; pfam13489 137722010566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722010567 S-adenosylmethionine binding site [chemical binding]; other site 137722010568 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 137722010569 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 137722010570 hypothetical protein; Provisional; Region: PRK06034 137722010571 Chorismate mutase type II; Region: CM_2; smart00830 137722010572 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 137722010573 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722010574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722010575 homodimer interface [polypeptide binding]; other site 137722010576 catalytic residue [active] 137722010577 cytosine deaminase; Validated; Region: PRK07572 137722010578 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 137722010579 active site 137722010580 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722010581 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 137722010582 TM-ABC transporter signature motif; other site 137722010583 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722010584 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 137722010585 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 137722010586 TM-ABC transporter signature motif; other site 137722010587 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 137722010588 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 137722010589 Walker A/P-loop; other site 137722010590 ATP binding site [chemical binding]; other site 137722010591 Q-loop/lid; other site 137722010592 ABC transporter signature motif; other site 137722010593 Walker B; other site 137722010594 D-loop; other site 137722010595 H-loop/switch region; other site 137722010596 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 137722010597 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 137722010598 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 137722010599 putative ligand binding site [chemical binding]; other site 137722010600 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 137722010601 Transcriptional regulator [Transcription]; Region: IclR; COG1414 137722010602 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722010603 putative DNA binding site [nucleotide binding]; other site 137722010604 putative Zn2+ binding site [ion binding]; other site 137722010605 Bacterial transcriptional regulator; Region: IclR; pfam01614 137722010606 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722010607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722010608 Walker A/P-loop; other site 137722010609 ATP binding site [chemical binding]; other site 137722010610 Q-loop/lid; other site 137722010611 ABC transporter signature motif; other site 137722010612 Walker B; other site 137722010613 D-loop; other site 137722010614 H-loop/switch region; other site 137722010615 TOBE domain; Region: TOBE_2; pfam08402 137722010616 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 137722010617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722010618 dimer interface [polypeptide binding]; other site 137722010619 conserved gate region; other site 137722010620 putative PBP binding loops; other site 137722010621 ABC-ATPase subunit interface; other site 137722010622 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722010623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722010624 dimer interface [polypeptide binding]; other site 137722010625 conserved gate region; other site 137722010626 putative PBP binding loops; other site 137722010627 ABC-ATPase subunit interface; other site 137722010628 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 137722010629 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 137722010630 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 137722010631 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 137722010632 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 137722010633 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 137722010634 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 137722010635 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 137722010636 muropeptide transporter; Validated; Region: ampG; cl17669 137722010637 muropeptide transporter; Reviewed; Region: ampG; PRK11902 137722010638 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 137722010639 dimanganese center [ion binding]; other site 137722010640 glutathione reductase; Validated; Region: PRK06116 137722010641 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 137722010642 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 137722010643 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 137722010644 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 137722010645 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 137722010646 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 137722010647 active site 137722010648 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 137722010649 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 137722010650 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 137722010651 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 137722010652 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 137722010653 intersubunit interface [polypeptide binding]; other site 137722010654 active site 137722010655 catalytic residue [active] 137722010656 purine nucleoside phosphorylase; Provisional; Region: PRK08202 137722010657 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 137722010658 active site 137722010659 catalytic motif [active] 137722010660 Zn binding site [ion binding]; other site 137722010661 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722010662 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 137722010663 TM-ABC transporter signature motif; other site 137722010664 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 137722010665 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722010666 TM-ABC transporter signature motif; other site 137722010667 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 137722010668 dimer interface [polypeptide binding]; other site 137722010669 [2Fe-2S] cluster binding site [ion binding]; other site 137722010670 EamA-like transporter family; Region: EamA; pfam00892 137722010671 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 137722010672 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 137722010673 ligand binding site [chemical binding]; other site 137722010674 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722010675 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722010676 TM-ABC transporter signature motif; other site 137722010677 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 137722010678 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722010679 TM-ABC transporter signature motif; other site 137722010680 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722010681 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722010682 Walker A/P-loop; other site 137722010683 ATP binding site [chemical binding]; other site 137722010684 Q-loop/lid; other site 137722010685 ABC transporter signature motif; other site 137722010686 Walker B; other site 137722010687 D-loop; other site 137722010688 H-loop/switch region; other site 137722010689 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722010690 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722010691 Walker A/P-loop; other site 137722010692 ATP binding site [chemical binding]; other site 137722010693 Q-loop/lid; other site 137722010694 ABC transporter signature motif; other site 137722010695 Walker B; other site 137722010696 D-loop; other site 137722010697 H-loop/switch region; other site 137722010698 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 137722010699 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 137722010700 Cl- selectivity filter; other site 137722010701 Cl- binding residues [ion binding]; other site 137722010702 pore gating glutamate residue; other site 137722010703 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 137722010704 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 137722010705 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 137722010706 Clp protease; Region: CLP_protease; pfam00574 137722010707 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 137722010708 oligomer interface [polypeptide binding]; other site 137722010709 active site residues [active] 137722010710 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 137722010711 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 137722010712 active site 137722010713 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 137722010714 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 137722010715 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722010716 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722010717 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 137722010718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722010719 Response regulator receiver domain; Region: Response_reg; pfam00072 137722010720 active site 137722010721 phosphorylation site [posttranslational modification] 137722010722 intermolecular recognition site; other site 137722010723 dimerization interface [polypeptide binding]; other site 137722010724 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 137722010725 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 137722010726 catalytic center binding site [active] 137722010727 ATP binding site [chemical binding]; other site 137722010728 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 137722010729 putative hydrophobic ligand binding site [chemical binding]; other site 137722010730 Cytochrome c2 [Energy production and conversion]; Region: COG3474 137722010731 aminopeptidase N; Provisional; Region: pepN; PRK14015 137722010732 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 137722010733 active site 137722010734 Zn binding site [ion binding]; other site 137722010735 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722010736 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 137722010737 putative effector binding pocket; other site 137722010738 dimerization interface [polypeptide binding]; other site 137722010739 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 137722010740 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 137722010741 putative NAD(P) binding site [chemical binding]; other site 137722010742 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 137722010743 putative catalytic site [active] 137722010744 putative phosphate binding site [ion binding]; other site 137722010745 active site 137722010746 metal binding site A [ion binding]; metal-binding site 137722010747 DNA binding site [nucleotide binding] 137722010748 putative AP binding site [nucleotide binding]; other site 137722010749 putative metal binding site B [ion binding]; other site 137722010750 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 137722010751 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 137722010752 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 137722010753 Zn2+ binding site [ion binding]; other site 137722010754 Mg2+ binding site [ion binding]; other site 137722010755 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 137722010756 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 137722010757 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 137722010758 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 137722010759 active site 137722010760 HIGH motif; other site 137722010761 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 137722010762 KMSK motif region; other site 137722010763 tRNA binding surface [nucleotide binding]; other site 137722010764 DALR anticodon binding domain; Region: DALR_1; smart00836 137722010765 anticodon binding site; other site 137722010766 Sporulation related domain; Region: SPOR; pfam05036 137722010767 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 137722010768 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 137722010769 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 137722010770 Peptidase family M50; Region: Peptidase_M50; pfam02163 137722010771 active site 137722010772 putative substrate binding region [chemical binding]; other site 137722010773 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 137722010774 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 137722010775 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 137722010776 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 137722010777 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 137722010778 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 137722010779 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 137722010780 motif 1; other site 137722010781 active site 137722010782 motif 2; other site 137722010783 motif 3; other site 137722010784 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 137722010785 DHHA1 domain; Region: DHHA1; pfam02272 137722010786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722010787 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 137722010788 Walker A motif; other site 137722010789 ATP binding site [chemical binding]; other site 137722010790 Walker B motif; other site 137722010791 arginine finger; other site 137722010792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722010793 Walker A/P-loop; other site 137722010794 ATP binding site [chemical binding]; other site 137722010795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 137722010796 Q-loop/lid; other site 137722010797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722010798 Q-loop/lid; other site 137722010799 ABC transporter signature motif; other site 137722010800 Walker B; other site 137722010801 D-loop; other site 137722010802 H-loop/switch region; other site 137722010803 exonuclease subunit SbcD; Provisional; Region: PRK10966 137722010804 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 137722010805 active site 137722010806 metal binding site [ion binding]; metal-binding site 137722010807 DNA binding site [nucleotide binding] 137722010808 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 137722010809 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 137722010810 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 137722010811 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 137722010812 DctM-like transporters; Region: DctM; pfam06808 137722010813 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 137722010814 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 137722010815 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 137722010816 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 137722010817 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 137722010818 PYR/PP interface [polypeptide binding]; other site 137722010819 dimer interface [polypeptide binding]; other site 137722010820 TPP binding site [chemical binding]; other site 137722010821 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 137722010822 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 137722010823 TPP-binding site [chemical binding]; other site 137722010824 dimer interface [polypeptide binding]; other site 137722010825 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 137722010826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722010827 NAD(P) binding site [chemical binding]; other site 137722010828 active site 137722010829 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 137722010830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722010831 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 137722010832 dimerization interface [polypeptide binding]; other site 137722010833 substrate binding pocket [chemical binding]; other site 137722010834 HAMP domain; Region: HAMP; pfam00672 137722010835 dimerization interface [polypeptide binding]; other site 137722010836 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722010837 dimer interface [polypeptide binding]; other site 137722010838 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 137722010839 putative CheW interface [polypeptide binding]; other site 137722010840 Integrase core domain; Region: rve; pfam00665 137722010841 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 137722010842 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 137722010843 active site 137722010844 tetramer interface [polypeptide binding]; other site 137722010845 galactarate dehydratase; Region: galactar-dH20; TIGR03248 137722010846 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 137722010847 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 137722010848 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 137722010849 tartronate semialdehyde reductase; Provisional; Region: PRK15059 137722010850 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 137722010851 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 137722010852 mannonate dehydratase; Region: uxuA; TIGR00695 137722010853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722010854 D-galactonate transporter; Region: 2A0114; TIGR00893 137722010855 putative substrate translocation pore; other site 137722010856 Transcriptional regulators [Transcription]; Region: PurR; COG1609 137722010857 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 137722010858 DNA binding site [nucleotide binding] 137722010859 domain linker motif; other site 137722010860 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 137722010861 putative dimerization interface [polypeptide binding]; other site 137722010862 putative ligand binding site [chemical binding]; other site 137722010863 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 137722010864 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 137722010865 active site 137722010866 dimer interface [polypeptide binding]; other site 137722010867 non-prolyl cis peptide bond; other site 137722010868 insertion regions; other site 137722010869 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 137722010870 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722010871 substrate binding pocket [chemical binding]; other site 137722010872 membrane-bound complex binding site; other site 137722010873 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 137722010874 Putative phosphatase (DUF442); Region: DUF442; cl17385 137722010875 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 137722010876 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 137722010877 active site 137722010878 non-prolyl cis peptide bond; other site 137722010879 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722010880 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722010881 Walker A/P-loop; other site 137722010882 ATP binding site [chemical binding]; other site 137722010883 Q-loop/lid; other site 137722010884 ABC transporter signature motif; other site 137722010885 Walker B; other site 137722010886 D-loop; other site 137722010887 H-loop/switch region; other site 137722010888 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722010889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722010890 dimer interface [polypeptide binding]; other site 137722010891 conserved gate region; other site 137722010892 putative PBP binding loops; other site 137722010893 ABC-ATPase subunit interface; other site 137722010894 NMT1/THI5 like; Region: NMT1; pfam09084 137722010895 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722010896 substrate binding pocket [chemical binding]; other site 137722010897 membrane-bound complex binding site; other site 137722010898 hinge residues; other site 137722010899 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722010900 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722010901 substrate binding pocket [chemical binding]; other site 137722010902 membrane-bound complex binding site; other site 137722010903 hinge residues; other site 137722010904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722010905 dimer interface [polypeptide binding]; other site 137722010906 conserved gate region; other site 137722010907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 137722010908 ABC-ATPase subunit interface; other site 137722010909 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 137722010910 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 137722010911 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 137722010912 Walker A/P-loop; other site 137722010913 ATP binding site [chemical binding]; other site 137722010914 Q-loop/lid; other site 137722010915 ABC transporter signature motif; other site 137722010916 Walker B; other site 137722010917 D-loop; other site 137722010918 H-loop/switch region; other site 137722010919 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 137722010920 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 137722010921 homodimer interface [polypeptide binding]; other site 137722010922 substrate-cofactor binding pocket; other site 137722010923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722010924 catalytic residue [active] 137722010925 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 137722010926 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 137722010927 dihydropyrimidinase; Provisional; Region: PRK13404 137722010928 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 137722010929 tetramer interface [polypeptide binding]; other site 137722010930 active site 137722010931 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 137722010932 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 137722010933 hydroxyglutarate oxidase; Provisional; Region: PRK11728 137722010934 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 137722010935 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 137722010936 Walker A/P-loop; other site 137722010937 ATP binding site [chemical binding]; other site 137722010938 Q-loop/lid; other site 137722010939 ABC transporter signature motif; other site 137722010940 Walker B; other site 137722010941 D-loop; other site 137722010942 H-loop/switch region; other site 137722010943 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722010944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722010945 DNA-binding site [nucleotide binding]; DNA binding site 137722010946 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 137722010947 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 137722010948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722010949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722010950 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 137722010951 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 137722010952 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722010953 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 137722010954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722010955 Walker A/P-loop; other site 137722010956 ATP binding site [chemical binding]; other site 137722010957 Q-loop/lid; other site 137722010958 ABC transporter signature motif; other site 137722010959 Walker B; other site 137722010960 D-loop; other site 137722010961 H-loop/switch region; other site 137722010962 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 137722010963 putative active site [active] 137722010964 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 137722010965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722010966 Walker A/P-loop; other site 137722010967 ATP binding site [chemical binding]; other site 137722010968 Q-loop/lid; other site 137722010969 ABC transporter signature motif; other site 137722010970 Walker B; other site 137722010971 D-loop; other site 137722010972 H-loop/switch region; other site 137722010973 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 137722010974 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 137722010975 Protein of unknown function (DUF770); Region: DUF770; pfam05591 137722010976 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 137722010977 Protein of unknown function (DUF877); Region: DUF877; pfam05943 137722010978 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 137722010979 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 137722010980 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 137722010981 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 137722010982 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 137722010983 anti sigma factor interaction site; other site 137722010984 regulatory phosphorylation site [posttranslational modification]; other site 137722010985 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 137722010986 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 137722010987 Catalytic domain of Protein Kinases; Region: PKc; cd00180 137722010988 active site 137722010989 ATP binding site [chemical binding]; other site 137722010990 substrate binding site [chemical binding]; other site 137722010991 activation loop (A-loop); other site 137722010992 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 137722010993 active site 137722010994 Protein phosphatase 2C; Region: PP2C; pfam00481 137722010995 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 137722010996 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 137722010997 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 137722010998 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 137722010999 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 137722011000 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 137722011001 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 137722011002 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 137722011003 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 137722011004 phosphopeptide binding site; other site 137722011005 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 137722011006 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 137722011007 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 137722011008 PAAR motif; Region: PAAR_motif; pfam05488 137722011009 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 137722011010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722011011 Walker A motif; other site 137722011012 ATP binding site [chemical binding]; other site 137722011013 Walker B motif; other site 137722011014 arginine finger; other site 137722011015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722011016 Walker A motif; other site 137722011017 ATP binding site [chemical binding]; other site 137722011018 Walker B motif; other site 137722011019 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 137722011020 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 137722011021 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 137722011022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722011023 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 137722011024 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 137722011025 DNA binding site [nucleotide binding] 137722011026 active site 137722011027 ABC-2 type transporter; Region: ABC2_membrane; cl17235 137722011028 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 137722011029 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 137722011030 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722011031 Walker A/P-loop; other site 137722011032 ATP binding site [chemical binding]; other site 137722011033 Q-loop/lid; other site 137722011034 ABC transporter signature motif; other site 137722011035 Walker B; other site 137722011036 D-loop; other site 137722011037 H-loop/switch region; other site 137722011038 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 137722011039 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 137722011040 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 137722011041 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 137722011042 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 137722011043 ligand binding site [chemical binding]; other site 137722011044 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722011045 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722011046 substrate binding pocket [chemical binding]; other site 137722011047 membrane-bound complex binding site; other site 137722011048 hinge residues; other site 137722011049 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 137722011050 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 137722011051 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 137722011052 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 137722011053 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 137722011054 dimer interface [polypeptide binding]; other site 137722011055 Trp docking motif [polypeptide binding]; other site 137722011056 active site 137722011057 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 137722011058 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 137722011059 Tetratricopeptide repeat; Region: TPR_16; pfam13432 137722011060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011061 TPR motif; other site 137722011062 binding surface 137722011063 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722011064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 137722011065 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 137722011066 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722011067 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722011068 TM-ABC transporter signature motif; other site 137722011069 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 137722011070 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722011071 TM-ABC transporter signature motif; other site 137722011072 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722011073 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722011074 Walker A/P-loop; other site 137722011075 ATP binding site [chemical binding]; other site 137722011076 Q-loop/lid; other site 137722011077 ABC transporter signature motif; other site 137722011078 Walker B; other site 137722011079 D-loop; other site 137722011080 H-loop/switch region; other site 137722011081 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 137722011082 active site 137722011083 catalytic residues [active] 137722011084 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 137722011085 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722011086 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722011087 metal binding site [ion binding]; metal-binding site 137722011088 active site 137722011089 I-site; other site 137722011090 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722011091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722011092 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 137722011093 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 137722011094 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722011095 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722011096 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 137722011097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722011098 putative substrate translocation pore; other site 137722011099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722011100 homoserine O-acetyltransferase; Provisional; Region: PRK06765 137722011101 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 137722011102 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 137722011103 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 137722011104 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 137722011105 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 137722011106 RNA binding site [nucleotide binding]; other site 137722011107 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722011108 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722011109 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722011110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722011111 Homeodomain-like domain; Region: HTH_23; cl17451 137722011112 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 137722011113 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722011114 dimer interface [polypeptide binding]; other site 137722011115 putative CheW interface [polypeptide binding]; other site 137722011116 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 137722011117 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 137722011118 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 137722011119 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 137722011120 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 137722011121 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 137722011122 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 137722011123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011124 binding surface 137722011125 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722011126 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 137722011127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722011128 putative active site [active] 137722011129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722011130 heme pocket [chemical binding]; other site 137722011131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722011132 ATP binding site [chemical binding]; other site 137722011133 Mg2+ binding site [ion binding]; other site 137722011134 G-X-G motif; other site 137722011135 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 137722011136 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 137722011137 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 137722011138 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 137722011139 C-terminal domain interface [polypeptide binding]; other site 137722011140 GSH binding site (G-site) [chemical binding]; other site 137722011141 dimer interface [polypeptide binding]; other site 137722011142 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 137722011143 N-terminal domain interface [polypeptide binding]; other site 137722011144 putative dimer interface [polypeptide binding]; other site 137722011145 active site 137722011146 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 137722011147 CoenzymeA binding site [chemical binding]; other site 137722011148 subunit interaction site [polypeptide binding]; other site 137722011149 PHB binding site; other site 137722011150 enoyl-CoA hydratase; Provisional; Region: PRK07511 137722011151 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722011152 substrate binding site [chemical binding]; other site 137722011153 oxyanion hole (OAH) forming residues; other site 137722011154 trimer interface [polypeptide binding]; other site 137722011155 Response regulator receiver domain; Region: Response_reg; pfam00072 137722011156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722011157 active site 137722011158 phosphorylation site [posttranslational modification] 137722011159 intermolecular recognition site; other site 137722011160 dimerization interface [polypeptide binding]; other site 137722011161 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 137722011162 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 137722011163 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 137722011164 active site 137722011165 catalytic site [active] 137722011166 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 137722011167 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 137722011168 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 137722011169 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 137722011170 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 137722011171 catalytic site [active] 137722011172 active site 137722011173 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 137722011174 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 137722011175 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 137722011176 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 137722011177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722011178 active site 137722011179 phosphorylation site [posttranslational modification] 137722011180 intermolecular recognition site; other site 137722011181 dimerization interface [polypeptide binding]; other site 137722011182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722011183 Walker A motif; other site 137722011184 ATP binding site [chemical binding]; other site 137722011185 Walker B motif; other site 137722011186 arginine finger; other site 137722011187 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 137722011188 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 137722011189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722011190 dimer interface [polypeptide binding]; other site 137722011191 phosphorylation site [posttranslational modification] 137722011192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722011193 ATP binding site [chemical binding]; other site 137722011194 Mg2+ binding site [ion binding]; other site 137722011195 G-X-G motif; other site 137722011196 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 137722011197 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 137722011198 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 137722011199 Malic enzyme, N-terminal domain; Region: malic; pfam00390 137722011200 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 137722011201 putative NAD(P) binding site [chemical binding]; other site 137722011202 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 137722011203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011204 TPR motif; other site 137722011205 binding surface 137722011206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011207 TPR motif; other site 137722011208 binding surface 137722011209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011210 binding surface 137722011211 TPR motif; other site 137722011212 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722011213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011214 binding surface 137722011215 TPR repeat; Region: TPR_11; pfam13414 137722011216 TPR motif; other site 137722011217 TPR repeat; Region: TPR_11; pfam13414 137722011218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011219 binding surface 137722011220 TPR motif; other site 137722011221 TPR repeat; Region: TPR_11; pfam13414 137722011222 TPR repeat; Region: TPR_11; pfam13414 137722011223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011224 binding surface 137722011225 TPR motif; other site 137722011226 TPR repeat; Region: TPR_11; pfam13414 137722011227 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 137722011228 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 137722011229 Substrate binding site; other site 137722011230 Mg++ binding site; other site 137722011231 metal-binding site 137722011232 Mg++ binding site; other site 137722011233 metal-binding site 137722011234 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 137722011235 Glycosyltransferase family 28 N-terminal domain; Region: Glyco_transf_28; pfam03033 137722011236 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 137722011237 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 137722011238 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 137722011239 active site 137722011240 acyl-activating enzyme (AAE) consensus motif; other site 137722011241 putative CoA binding site [chemical binding]; other site 137722011242 AMP binding site [chemical binding]; other site 137722011243 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 137722011244 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722011245 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722011246 Walker A/P-loop; other site 137722011247 ATP binding site [chemical binding]; other site 137722011248 Q-loop/lid; other site 137722011249 ABC transporter signature motif; other site 137722011250 Walker B; other site 137722011251 D-loop; other site 137722011252 H-loop/switch region; other site 137722011253 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722011254 substrate binding pocket [chemical binding]; other site 137722011255 membrane-bound complex binding site; other site 137722011256 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722011257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722011258 dimer interface [polypeptide binding]; other site 137722011259 conserved gate region; other site 137722011260 putative PBP binding loops; other site 137722011261 ABC-ATPase subunit interface; other site 137722011262 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722011263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722011264 Walker A/P-loop; other site 137722011265 ATP binding site [chemical binding]; other site 137722011266 Q-loop/lid; other site 137722011267 ABC transporter signature motif; other site 137722011268 Walker B; other site 137722011269 D-loop; other site 137722011270 H-loop/switch region; other site 137722011271 Protein of unknown function (DUF461); Region: DUF461; pfam04314 137722011272 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722011273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722011274 active site 137722011275 phosphorylation site [posttranslational modification] 137722011276 intermolecular recognition site; other site 137722011277 dimerization interface [polypeptide binding]; other site 137722011278 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722011279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722011280 active site 137722011281 phosphorylation site [posttranslational modification] 137722011282 intermolecular recognition site; other site 137722011283 dimerization interface [polypeptide binding]; other site 137722011284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722011285 putative active site [active] 137722011286 PAS fold; Region: PAS_3; pfam08447 137722011287 heme pocket [chemical binding]; other site 137722011288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 137722011289 HWE histidine kinase; Region: HWE_HK; pfam07536 137722011290 Response regulator receiver domain; Region: Response_reg; pfam00072 137722011291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722011292 active site 137722011293 phosphorylation site [posttranslational modification] 137722011294 intermolecular recognition site; other site 137722011295 dimerization interface [polypeptide binding]; other site 137722011296 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 137722011297 GAF domain; Region: GAF; pfam01590 137722011298 Phytochrome region; Region: PHY; pfam00360 137722011299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722011300 dimer interface [polypeptide binding]; other site 137722011301 phosphorylation site [posttranslational modification] 137722011302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722011303 ATP binding site [chemical binding]; other site 137722011304 Mg2+ binding site [ion binding]; other site 137722011305 G-X-G motif; other site 137722011306 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 137722011307 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722011308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 137722011309 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722011310 Winged helix-turn helix; Region: HTH_29; pfam13551 137722011311 Winged helix-turn helix; Region: HTH_33; pfam13592 137722011312 Homeodomain-like domain; Region: HTH_23; cl17451 137722011313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 137722011314 Homeodomain-like domain; Region: HTH_32; pfam13565 137722011315 Integrase core domain; Region: rve; pfam00665 137722011316 Integrase core domain; Region: rve_3; pfam13683 137722011317 Autoinducer synthetase; Region: Autoind_synth; cl17404 137722011318 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 137722011319 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 137722011320 homodimer interface [polypeptide binding]; other site 137722011321 substrate-cofactor binding pocket; other site 137722011322 catalytic residue [active] 137722011323 MbtH-like protein; Region: MbtH; cl01279 137722011324 Thioesterase domain; Region: Thioesterase; pfam00975 137722011325 Condensation domain; Region: Condensation; pfam00668 137722011326 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 137722011327 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722011328 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 137722011329 acyl-activating enzyme (AAE) consensus motif; other site 137722011330 AMP binding site [chemical binding]; other site 137722011331 active site 137722011332 CoA binding site [chemical binding]; other site 137722011333 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722011334 Condensation domain; Region: Condensation; pfam00668 137722011335 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 137722011336 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 137722011337 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 137722011338 acyl-activating enzyme (AAE) consensus motif; other site 137722011339 AMP binding site [chemical binding]; other site 137722011340 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722011341 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 137722011342 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 137722011343 active site 137722011344 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722011345 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722011346 Condensation domain; Region: Condensation; pfam00668 137722011347 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 137722011348 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 137722011349 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 137722011350 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 137722011351 dimer interface [polypeptide binding]; other site 137722011352 active site 137722011353 glycine-pyridoxal phosphate binding site [chemical binding]; other site 137722011354 folate binding site [chemical binding]; other site 137722011355 Condensation domain; Region: Condensation; pfam00668 137722011356 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 137722011357 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 137722011358 acyl-activating enzyme (AAE) consensus motif; other site 137722011359 AMP binding site [chemical binding]; other site 137722011360 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722011361 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 137722011362 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 137722011363 conserved cys residue [active] 137722011364 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722011365 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 137722011366 acyl-activating enzyme (AAE) consensus motif; other site 137722011367 AMP binding site [chemical binding]; other site 137722011368 active site 137722011369 CoA binding site [chemical binding]; other site 137722011370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722011371 NAD(P) binding site [chemical binding]; other site 137722011372 active site 137722011373 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 137722011374 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 137722011375 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 137722011376 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 137722011377 dimer interface [polypeptide binding]; other site 137722011378 motif 1; other site 137722011379 active site 137722011380 motif 2; other site 137722011381 motif 3; other site 137722011382 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 137722011383 B3/4 domain; Region: B3_4; pfam03483 137722011384 tRNA synthetase B5 domain; Region: B5; smart00874 137722011385 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 137722011386 motif 1; other site 137722011387 dimer interface [polypeptide binding]; other site 137722011388 active site 137722011389 motif 2; other site 137722011390 motif 3; other site 137722011391 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 137722011392 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_2; cd08822 137722011393 putative active site [active] 137722011394 putative substrate binding site [chemical binding]; other site 137722011395 putative cosubstrate binding site; other site 137722011396 catalytic site [active] 137722011397 Autoinducer binding domain; Region: Autoind_bind; pfam03472 137722011398 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722011399 DNA binding residues [nucleotide binding] 137722011400 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722011401 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 137722011402 catalytic residues [active] 137722011403 catalytic nucleophile [active] 137722011404 Presynaptic Site I dimer interface [polypeptide binding]; other site 137722011405 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 137722011406 Synaptic Flat tetramer interface [polypeptide binding]; other site 137722011407 Synaptic Site I dimer interface [polypeptide binding]; other site 137722011408 DNA binding site [nucleotide binding] 137722011409 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 137722011410 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 137722011411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722011412 Coenzyme A binding pocket [chemical binding]; other site 137722011413 Resolvase, N terminal domain; Region: Resolvase; smart00857 137722011414 catalytic nucleophile [active] 137722011415 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 137722011416 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 137722011417 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722011418 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722011419 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722011420 Benzoate membrane transport protein; Region: BenE; pfam03594 137722011421 benzoate transporter; Region: benE; TIGR00843 137722011422 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 137722011423 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 137722011424 active site 137722011425 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 137722011426 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 137722011427 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 137722011428 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 137722011429 homodimer interface [polypeptide binding]; other site 137722011430 substrate-cofactor binding pocket; other site 137722011431 catalytic residue [active] 137722011432 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 137722011433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722011434 NAD(P) binding site [chemical binding]; other site 137722011435 active site 137722011436 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 137722011437 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 137722011438 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 137722011439 Transposase; Region: HTH_Tnp_1; cl17663 137722011440 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722011441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722011442 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722011443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722011444 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722011445 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722011446 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722011447 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722011448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722011449 Walker A motif; other site 137722011450 ATP binding site [chemical binding]; other site 137722011451 Homeodomain-like domain; Region: HTH_23; cl17451 137722011452 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722011453 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722011454 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722011455 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722011456 MULE transposase domain; Region: MULE; pfam10551 137722011457 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722011458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722011459 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722011460 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722011461 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722011462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722011463 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722011464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722011465 Transposase; Region: HTH_Tnp_1; pfam01527 137722011466 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 137722011467 Transcriptional regulator [Transcription]; Region: IclR; COG1414 137722011468 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 137722011469 Bacterial transcriptional regulator; Region: IclR; pfam01614 137722011470 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 137722011471 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 137722011472 NAD binding site [chemical binding]; other site 137722011473 homotetramer interface [polypeptide binding]; other site 137722011474 homodimer interface [polypeptide binding]; other site 137722011475 active site 137722011476 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 137722011477 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 137722011478 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 137722011479 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 137722011480 Walker A/P-loop; other site 137722011481 ATP binding site [chemical binding]; other site 137722011482 Q-loop/lid; other site 137722011483 ABC transporter signature motif; other site 137722011484 Walker B; other site 137722011485 D-loop; other site 137722011486 H-loop/switch region; other site 137722011487 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 137722011488 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722011489 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 137722011490 TM-ABC transporter signature motif; other site 137722011491 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 137722011492 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 137722011493 putative ligand binding site [chemical binding]; other site 137722011494 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 137722011495 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 137722011496 active site 137722011497 catalytic tetrad [active] 137722011498 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 137722011499 Amidohydrolase; Region: Amidohydro_2; pfam04909 137722011500 active site 137722011501 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 137722011502 galactarate dehydratase; Region: galactar-dH20; TIGR03248 137722011503 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 137722011504 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 137722011505 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 137722011506 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 137722011507 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 137722011508 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 137722011509 active site 137722011510 catalytic site [active] 137722011511 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 137722011512 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 137722011513 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 137722011514 active site 137722011515 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 137722011516 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 137722011517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011518 TPR motif; other site 137722011519 binding surface 137722011520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 137722011521 binding surface 137722011522 TPR motif; other site 137722011523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011524 TPR motif; other site 137722011525 TPR repeat; Region: TPR_11; pfam13414 137722011526 binding surface 137722011527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011528 binding surface 137722011529 TPR motif; other site 137722011530 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 137722011531 Methyltransferase domain; Region: Methyltransf_11; pfam08241 137722011532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011533 binding surface 137722011534 TPR motif; other site 137722011535 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 137722011536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011537 binding surface 137722011538 TPR motif; other site 137722011539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011540 binding surface 137722011541 TPR motif; other site 137722011542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011543 binding surface 137722011544 TPR motif; other site 137722011545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011546 TPR repeat; Region: TPR_11; pfam13414 137722011547 binding surface 137722011548 TPR motif; other site 137722011549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011550 binding surface 137722011551 TPR motif; other site 137722011552 TPR repeat; Region: TPR_11; pfam13414 137722011553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011554 binding surface 137722011555 TPR motif; other site 137722011556 Tetratricopeptide repeat; Region: TPR_16; pfam13432 137722011557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011558 TPR motif; other site 137722011559 binding surface 137722011560 Protein of unknown function (DUF465); Region: DUF465; cl01070 137722011561 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011562 TPR motif; other site 137722011563 binding surface 137722011564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011565 binding surface 137722011566 TPR repeat; Region: TPR_11; pfam13414 137722011567 TPR motif; other site 137722011568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011569 binding surface 137722011570 TPR motif; other site 137722011571 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 137722011572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011573 binding surface 137722011574 TPR motif; other site 137722011575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011576 binding surface 137722011577 TPR motif; other site 137722011578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011579 TPR motif; other site 137722011580 binding surface 137722011581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011582 TPR repeat; Region: TPR_11; pfam13414 137722011583 binding surface 137722011584 TPR motif; other site 137722011585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011586 TPR motif; other site 137722011587 binding surface 137722011588 Tetratricopeptide repeat; Region: TPR_12; pfam13424 137722011589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722011590 TPR motif; other site 137722011591 binding surface 137722011592 Tetratricopeptide repeat; Region: TPR_12; pfam13424 137722011593 Flagellar protein FlbT; Region: FlbT; cl11455 137722011594 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 137722011595 hypothetical protein; Validated; Region: PRK06840 137722011596 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 137722011597 dimer interface [polypeptide binding]; other site 137722011598 active site 137722011599 CoA binding pocket [chemical binding]; other site 137722011600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722011601 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 137722011602 NAD(P) binding site [chemical binding]; other site 137722011603 active site 137722011604 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 137722011605 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722011606 active site 137722011607 CoA binding site [chemical binding]; other site 137722011608 AMP binding site [chemical binding]; other site 137722011609 Phosphopantetheine attachment site; Region: PP-binding; cl09936 137722011610 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 137722011611 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 137722011612 ligand binding site; other site 137722011613 pseudaminic acid synthase; Region: PseI; TIGR03586 137722011614 NeuB family; Region: NeuB; pfam03102 137722011615 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 137722011616 NeuB binding interface [polypeptide binding]; other site 137722011617 putative substrate binding site [chemical binding]; other site 137722011618 tellurium resistance terB-like protein; Region: terB_like; cl11965 137722011619 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722011620 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 137722011621 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722011622 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722011623 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 137722011624 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722011625 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722011626 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722011627 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722011628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722011629 dimer interface [polypeptide binding]; other site 137722011630 phosphorylation site [posttranslational modification] 137722011631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722011632 ATP binding site [chemical binding]; other site 137722011633 Mg2+ binding site [ion binding]; other site 137722011634 G-X-G motif; other site 137722011635 Response regulator receiver domain; Region: Response_reg; pfam00072 137722011636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722011637 active site 137722011638 phosphorylation site [posttranslational modification] 137722011639 intermolecular recognition site; other site 137722011640 dimerization interface [polypeptide binding]; other site 137722011641 Helix-turn-helix domain; Region: HTH_36; pfam13730 137722011642 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 137722011643 catalytic core [active] 137722011644 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 137722011645 DEAD-like helicases superfamily; Region: DEXDc; smart00487 137722011646 DEAD/DEAH box helicase; Region: DEAD; pfam00270 137722011647 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722011648 nucleotide binding region [chemical binding]; other site 137722011649 ATP-binding site [chemical binding]; other site 137722011650 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 137722011651 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 137722011652 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 137722011653 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 137722011654 Chain length determinant protein; Region: Wzz; pfam02706 137722011655 Chain length determinant protein; Region: Wzz; cl15801 137722011656 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 137722011657 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 137722011658 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 137722011659 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722011660 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722011661 dimerization interface [polypeptide binding]; other site 137722011662 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 137722011663 iron-sulfur cluster [ion binding]; other site 137722011664 [2Fe-2S] cluster binding site [ion binding]; other site 137722011665 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 137722011666 putative alpha subunit interface [polypeptide binding]; other site 137722011667 putative active site [active] 137722011668 putative substrate binding site [chemical binding]; other site 137722011669 Fe binding site [ion binding]; other site 137722011670 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 137722011671 inter-subunit interface; other site 137722011672 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 137722011673 [2Fe-2S] cluster binding site [ion binding]; other site 137722011674 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 137722011675 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 137722011676 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 137722011677 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 137722011678 putative ligand binding site [chemical binding]; other site 137722011679 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722011680 TM-ABC transporter signature motif; other site 137722011681 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 137722011682 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722011683 TM-ABC transporter signature motif; other site 137722011684 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722011685 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722011686 Walker A/P-loop; other site 137722011687 ATP binding site [chemical binding]; other site 137722011688 Q-loop/lid; other site 137722011689 ABC transporter signature motif; other site 137722011690 Walker B; other site 137722011691 D-loop; other site 137722011692 H-loop/switch region; other site 137722011693 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722011694 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722011695 Walker A/P-loop; other site 137722011696 ATP binding site [chemical binding]; other site 137722011697 Q-loop/lid; other site 137722011698 ABC transporter signature motif; other site 137722011699 Walker B; other site 137722011700 D-loop; other site 137722011701 H-loop/switch region; other site 137722011702 Helix-turn-helix domain; Region: HTH_18; pfam12833 137722011703 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 137722011704 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 137722011705 dimer interface [polypeptide binding]; other site 137722011706 active site 137722011707 Muconolactone delta-isomerase; Region: MIase; cl01992 137722011708 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 137722011709 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 137722011710 metal binding site [ion binding]; metal-binding site 137722011711 substrate binding pocket [chemical binding]; other site 137722011712 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 137722011713 benzoate transport; Region: 2A0115; TIGR00895 137722011714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 137722011715 Carboxylesterase family; Region: COesterase; pfam00135 137722011716 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 137722011717 substrate binding pocket [chemical binding]; other site 137722011718 catalytic triad [active] 137722011719 LysR family transcriptional regulator; Provisional; Region: PRK14997 137722011720 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722011721 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 137722011722 putative effector binding pocket; other site 137722011723 Methyltransferase domain; Region: Methyltransf_31; pfam13847 137722011724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722011725 S-adenosylmethionine binding site [chemical binding]; other site 137722011726 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 137722011727 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 137722011728 Calx-beta domain; Region: Calx-beta; pfam03160 137722011729 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 137722011730 trimer interface [polypeptide binding]; other site 137722011731 active site 137722011732 substrate binding site [chemical binding]; other site 137722011733 CoA binding site [chemical binding]; other site 137722011734 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 137722011735 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 137722011736 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 137722011737 Bacterial sugar transferase; Region: Bac_transf; pfam02397 137722011738 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 137722011739 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 137722011740 active site 137722011741 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 137722011742 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722011743 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722011744 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 137722011745 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 137722011746 putative active site [active] 137722011747 putative metal binding site [ion binding]; other site 137722011748 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 137722011749 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 137722011750 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722011751 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722011752 acyl-activating enzyme (AAE) consensus motif; other site 137722011753 AMP binding site [chemical binding]; other site 137722011754 active site 137722011755 CoA binding site [chemical binding]; other site 137722011756 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 137722011757 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 137722011758 active site 137722011759 dimer interface [polypeptide binding]; other site 137722011760 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 137722011761 Ligand Binding Site [chemical binding]; other site 137722011762 Molecular Tunnel; other site 137722011763 NAD synthetase; Reviewed; Region: nadE; PRK00876 137722011764 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 137722011765 Ligand Binding Site [chemical binding]; other site 137722011766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 137722011767 putative cation:proton antiport protein; Provisional; Region: PRK10669 137722011768 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 137722011769 TrkA-N domain; Region: TrkA_N; pfam02254 137722011770 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 137722011771 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 137722011772 Walker A/P-loop; other site 137722011773 ATP binding site [chemical binding]; other site 137722011774 Q-loop/lid; other site 137722011775 ABC transporter signature motif; other site 137722011776 Walker B; other site 137722011777 D-loop; other site 137722011778 H-loop/switch region; other site 137722011779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722011780 dimer interface [polypeptide binding]; other site 137722011781 conserved gate region; other site 137722011782 putative PBP binding loops; other site 137722011783 ABC-ATPase subunit interface; other site 137722011784 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 137722011785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722011786 dimer interface [polypeptide binding]; other site 137722011787 conserved gate region; other site 137722011788 putative PBP binding loops; other site 137722011789 ABC-ATPase subunit interface; other site 137722011790 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 137722011791 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 137722011792 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 137722011793 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 137722011794 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 137722011795 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722011796 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 137722011797 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722011798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722011799 S-adenosylmethionine binding site [chemical binding]; other site 137722011800 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 137722011801 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 137722011802 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722011803 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722011804 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 137722011805 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722011806 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722011807 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 137722011808 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 137722011809 Walker A/P-loop; other site 137722011810 ATP binding site [chemical binding]; other site 137722011811 Q-loop/lid; other site 137722011812 ABC transporter signature motif; other site 137722011813 Walker B; other site 137722011814 D-loop; other site 137722011815 H-loop/switch region; other site 137722011816 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 137722011817 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 137722011818 NAD binding site [chemical binding]; other site 137722011819 homodimer interface [polypeptide binding]; other site 137722011820 active site 137722011821 substrate binding site [chemical binding]; other site 137722011822 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722011823 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 137722011824 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 137722011825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722011826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722011827 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722011828 dimerization interface [polypeptide binding]; other site 137722011829 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 137722011830 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 137722011831 inhibitor-cofactor binding pocket; inhibition site 137722011832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722011833 catalytic residue [active] 137722011834 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 137722011835 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 137722011836 tetrameric interface [polypeptide binding]; other site 137722011837 NAD binding site [chemical binding]; other site 137722011838 catalytic residues [active] 137722011839 Nitrate and nitrite sensing; Region: NIT; pfam08376 137722011840 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 137722011841 ANTAR domain; Region: ANTAR; pfam03861 137722011842 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 137722011843 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 137722011844 Substrate binding site; other site 137722011845 Mg++ binding site; other site 137722011846 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 137722011847 active site 137722011848 substrate binding site [chemical binding]; other site 137722011849 CoA binding site [chemical binding]; other site 137722011850 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 137722011851 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 137722011852 glutaminase active site [active] 137722011853 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 137722011854 dimer interface [polypeptide binding]; other site 137722011855 active site 137722011856 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 137722011857 dimer interface [polypeptide binding]; other site 137722011858 active site 137722011859 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 137722011860 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722011861 Winged helix-turn helix; Region: HTH_29; pfam13551 137722011862 Winged helix-turn helix; Region: HTH_33; pfam13592 137722011863 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722011864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 137722011865 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 137722011866 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 137722011867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722011868 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722011869 dimerization interface [polypeptide binding]; other site 137722011870 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 137722011871 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 137722011872 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 137722011873 putative alpha subunit interface [polypeptide binding]; other site 137722011874 putative active site [active] 137722011875 putative substrate binding site [chemical binding]; other site 137722011876 Fe binding site [ion binding]; other site 137722011877 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 137722011878 inter-subunit interface; other site 137722011879 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 137722011880 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722011881 catalytic loop [active] 137722011882 iron binding site [ion binding]; other site 137722011883 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 137722011884 FAD binding pocket [chemical binding]; other site 137722011885 FAD binding motif [chemical binding]; other site 137722011886 phosphate binding motif [ion binding]; other site 137722011887 beta-alpha-beta structure motif; other site 137722011888 NAD binding pocket [chemical binding]; other site 137722011889 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 137722011890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722011891 NAD(P) binding site [chemical binding]; other site 137722011892 active site 137722011893 benzoate transport; Region: 2A0115; TIGR00895 137722011894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722011895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722011896 HTH-like domain; Region: HTH_21; pfam13276 137722011897 Integrase core domain; Region: rve; pfam00665 137722011898 Transposase domain (DUF772); Region: DUF772; pfam05598 137722011899 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722011900 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 137722011901 Transposase; Region: DEDD_Tnp_IS110; pfam01548 137722011902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 137722011903 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 137722011904 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 137722011905 DNA-binding interface [nucleotide binding]; DNA binding site 137722011906 Methyltransferase domain; Region: Methyltransf_23; pfam13489 137722011907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722011908 S-adenosylmethionine binding site [chemical binding]; other site 137722011909 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 137722011910 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722011911 Transposase domain (DUF772); Region: DUF772; pfam05598 137722011912 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722011913 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 137722011914 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722011915 Winged helix-turn helix; Region: HTH_29; pfam13551 137722011916 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722011917 Winged helix-turn helix; Region: HTH_33; pfam13592 137722011918 DDE superfamily endonuclease; Region: DDE_5; cl17874 137722011919 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722011920 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722011921 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722011922 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722011923 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722011924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722011925 Integrase core domain; Region: rve; pfam00665 137722011926 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722011927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722011928 Walker A motif; other site 137722011929 ATP binding site [chemical binding]; other site 137722011930 MobA/MobL family; Region: MobA_MobL; pfam03389 137722011931 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 137722011932 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722011933 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 137722011934 catalytic residues [active] 137722011935 catalytic nucleophile [active] 137722011936 Recombinase; Region: Recombinase; pfam07508 137722011937 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 137722011938 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 137722011939 TPP-binding site [chemical binding]; other site 137722011940 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 137722011941 PYR/PP interface [polypeptide binding]; other site 137722011942 dimer interface [polypeptide binding]; other site 137722011943 TPP binding site [chemical binding]; other site 137722011944 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 137722011945 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722011946 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722011947 putative DNA binding site [nucleotide binding]; other site 137722011948 putative Zn2+ binding site [ion binding]; other site 137722011949 AsnC family; Region: AsnC_trans_reg; pfam01037 137722011950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722011951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722011952 putative substrate translocation pore; other site 137722011953 short chain dehydrogenase; Provisional; Region: PRK06172 137722011954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722011955 NAD(P) binding site [chemical binding]; other site 137722011956 active site 137722011957 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 137722011958 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 137722011959 acyl-activating enzyme (AAE) consensus motif; other site 137722011960 AMP binding site [chemical binding]; other site 137722011961 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722011962 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 137722011963 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 137722011964 putative trimer interface [polypeptide binding]; other site 137722011965 putative CoA binding site [chemical binding]; other site 137722011966 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 137722011967 putative trimer interface [polypeptide binding]; other site 137722011968 putative CoA binding site [chemical binding]; other site 137722011969 fumarate hydratase; Provisional; Region: PRK15389 137722011970 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 137722011971 Fumarase C-terminus; Region: Fumerase_C; pfam05683 137722011972 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 137722011973 CcdB protein; Region: CcdB; cl03380 137722011974 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 137722011975 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 137722011976 active site 137722011977 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 137722011978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722011979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722011980 dimer interface [polypeptide binding]; other site 137722011981 phosphorylation site [posttranslational modification] 137722011982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722011983 ATP binding site [chemical binding]; other site 137722011984 Mg2+ binding site [ion binding]; other site 137722011985 G-X-G motif; other site 137722011986 Pirin-related protein [General function prediction only]; Region: COG1741 137722011987 Pirin; Region: Pirin; pfam02678 137722011988 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 137722011989 metal-binding site [ion binding] 137722011990 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 137722011991 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 137722011992 Soluble P-type ATPase [General function prediction only]; Region: COG4087 137722011993 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 137722011994 DNA binding residues [nucleotide binding] 137722011995 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 137722011996 dimer interface [polypeptide binding]; other site 137722011997 putative metal binding site [ion binding]; other site 137722011998 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 137722011999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722012000 DNA-binding site [nucleotide binding]; DNA binding site 137722012001 UTRA domain; Region: UTRA; cl17743 137722012002 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 137722012003 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 137722012004 Walker A/P-loop; other site 137722012005 ATP binding site [chemical binding]; other site 137722012006 Q-loop/lid; other site 137722012007 ABC transporter signature motif; other site 137722012008 Walker B; other site 137722012009 D-loop; other site 137722012010 H-loop/switch region; other site 137722012011 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 137722012012 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 137722012013 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 137722012014 N-terminal plug; other site 137722012015 ligand-binding site [chemical binding]; other site 137722012016 MbtH-like protein; Region: MbtH; cl01279 137722012017 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 137722012018 Condensation domain; Region: Condensation; pfam00668 137722012019 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 137722012020 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 137722012021 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 137722012022 acyl-activating enzyme (AAE) consensus motif; other site 137722012023 AMP binding site [chemical binding]; other site 137722012024 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722012025 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722012026 Condensation domain; Region: Condensation; pfam00668 137722012027 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 137722012028 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 137722012029 acyl-activating enzyme (AAE) consensus motif; other site 137722012030 AMP binding site [chemical binding]; other site 137722012031 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722012032 Condensation domain; Region: Condensation; pfam00668 137722012033 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 137722012034 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 137722012035 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 137722012036 acyl-activating enzyme (AAE) consensus motif; other site 137722012037 AMP binding site [chemical binding]; other site 137722012038 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722012039 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 137722012040 Condensation domain; Region: Condensation; pfam00668 137722012041 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 137722012042 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 137722012043 acyl-activating enzyme (AAE) consensus motif; other site 137722012044 AMP binding site [chemical binding]; other site 137722012045 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722012046 Condensation domain; Region: Condensation; pfam00668 137722012047 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 137722012048 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 137722012049 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 137722012050 acyl-activating enzyme (AAE) consensus motif; other site 137722012051 AMP binding site [chemical binding]; other site 137722012052 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722012053 Condensation domain; Region: Condensation; pfam00668 137722012054 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 137722012055 Condensation domain; Region: Condensation; pfam00668 137722012056 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 137722012057 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 137722012058 acyl-activating enzyme (AAE) consensus motif; other site 137722012059 AMP binding site [chemical binding]; other site 137722012060 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722012061 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722012062 Condensation domain; Region: Condensation; pfam00668 137722012063 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 137722012064 Condensation domain; Region: Condensation; pfam00668 137722012065 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 137722012066 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 137722012067 acyl-activating enzyme (AAE) consensus motif; other site 137722012068 AMP binding site [chemical binding]; other site 137722012069 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722012070 Thioesterase domain; Region: Thioesterase; pfam00975 137722012071 Transcriptional regulators [Transcription]; Region: PurR; COG1609 137722012072 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 137722012073 DNA binding site [nucleotide binding] 137722012074 domain linker motif; other site 137722012075 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 137722012076 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 137722012077 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 137722012078 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 137722012079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012080 dimer interface [polypeptide binding]; other site 137722012081 conserved gate region; other site 137722012082 putative PBP binding loops; other site 137722012083 ABC-ATPase subunit interface; other site 137722012084 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722012085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012086 dimer interface [polypeptide binding]; other site 137722012087 conserved gate region; other site 137722012088 putative PBP binding loops; other site 137722012089 ABC-ATPase subunit interface; other site 137722012090 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722012091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722012092 Walker A/P-loop; other site 137722012093 ATP binding site [chemical binding]; other site 137722012094 Q-loop/lid; other site 137722012095 ABC transporter signature motif; other site 137722012096 Walker B; other site 137722012097 D-loop; other site 137722012098 H-loop/switch region; other site 137722012099 TOBE domain; Region: TOBE_2; pfam08402 137722012100 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 137722012101 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 137722012102 active site 137722012103 metal binding site [ion binding]; metal-binding site 137722012104 hexamer interface [polypeptide binding]; other site 137722012105 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 137722012106 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 137722012107 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 137722012108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012109 dimer interface [polypeptide binding]; other site 137722012110 conserved gate region; other site 137722012111 putative PBP binding loops; other site 137722012112 ABC-ATPase subunit interface; other site 137722012113 putative oxidoreductase; Provisional; Region: PRK11579 137722012114 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 137722012115 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 137722012116 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722012117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012118 dimer interface [polypeptide binding]; other site 137722012119 conserved gate region; other site 137722012120 putative PBP binding loops; other site 137722012121 ABC-ATPase subunit interface; other site 137722012122 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 137722012123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012124 dimer interface [polypeptide binding]; other site 137722012125 conserved gate region; other site 137722012126 ABC-ATPase subunit interface; other site 137722012127 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 137722012128 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 137722012129 Walker A/P-loop; other site 137722012130 ATP binding site [chemical binding]; other site 137722012131 Q-loop/lid; other site 137722012132 ABC transporter signature motif; other site 137722012133 Walker B; other site 137722012134 D-loop; other site 137722012135 H-loop/switch region; other site 137722012136 TOBE domain; Region: TOBE; pfam03459 137722012137 CcdB protein; Region: CcdB; cl03380 137722012138 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 137722012139 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 137722012140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722012141 ATP binding site [chemical binding]; other site 137722012142 Mg2+ binding site [ion binding]; other site 137722012143 G-X-G motif; other site 137722012144 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722012145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722012146 active site 137722012147 phosphorylation site [posttranslational modification] 137722012148 intermolecular recognition site; other site 137722012149 dimerization interface [polypeptide binding]; other site 137722012150 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722012151 DNA binding site [nucleotide binding] 137722012152 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 137722012153 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 137722012154 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 137722012155 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 137722012156 tetramer interface [polypeptide binding]; other site 137722012157 catalytic Zn binding site [ion binding]; other site 137722012158 NADP binding site [chemical binding]; other site 137722012159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 137722012160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 137722012161 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722012162 dimerization interface [polypeptide binding]; other site 137722012163 putative DNA binding site [nucleotide binding]; other site 137722012164 putative Zn2+ binding site [ion binding]; other site 137722012165 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 137722012166 Low molecular weight phosphatase family; Region: LMWPc; cd00115 137722012167 active site 137722012168 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 137722012169 Sodium Bile acid symporter family; Region: SBF; cl17470 137722012170 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 137722012171 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 137722012172 putative catalytic cysteine [active] 137722012173 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 137722012174 putative active site [active] 137722012175 metal binding site [ion binding]; metal-binding site 137722012176 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 137722012177 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 137722012178 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 137722012179 GAF domain; Region: GAF; pfam01590 137722012180 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722012181 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 137722012182 nucleotidyl binding site; other site 137722012183 metal binding site [ion binding]; metal-binding site 137722012184 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722012185 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 137722012186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 137722012187 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 137722012188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722012189 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 137722012190 dimerization interface [polypeptide binding]; other site 137722012191 substrate binding pocket [chemical binding]; other site 137722012192 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 137722012193 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 137722012194 FOG: CBS domain [General function prediction only]; Region: COG0517 137722012195 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 137722012196 BON domain; Region: BON; pfam04972 137722012197 Transcriptional regulator [Transcription]; Region: IclR; COG1414 137722012198 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 137722012199 Bacterial transcriptional regulator; Region: IclR; pfam01614 137722012200 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 137722012201 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 137722012202 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 137722012203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012204 dimer interface [polypeptide binding]; other site 137722012205 conserved gate region; other site 137722012206 putative PBP binding loops; other site 137722012207 ABC-ATPase subunit interface; other site 137722012208 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722012209 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722012210 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722012211 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722012212 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 137722012213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012214 dimer interface [polypeptide binding]; other site 137722012215 conserved gate region; other site 137722012216 putative PBP binding loops; other site 137722012217 ABC-ATPase subunit interface; other site 137722012218 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 137722012219 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 137722012220 active site 137722012221 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 137722012222 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 137722012223 homotrimer interaction site [polypeptide binding]; other site 137722012224 putative active site [active] 137722012225 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 137722012226 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 137722012227 dimer interface [polypeptide binding]; other site 137722012228 active site 137722012229 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 137722012230 substrate binding site [chemical binding]; other site 137722012231 catalytic residue [active] 137722012232 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 137722012233 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722012234 Walker A/P-loop; other site 137722012235 ATP binding site [chemical binding]; other site 137722012236 Q-loop/lid; other site 137722012237 ABC transporter signature motif; other site 137722012238 Walker B; other site 137722012239 D-loop; other site 137722012240 H-loop/switch region; other site 137722012241 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722012242 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 137722012243 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722012244 Walker A/P-loop; other site 137722012245 ATP binding site [chemical binding]; other site 137722012246 Q-loop/lid; other site 137722012247 ABC transporter signature motif; other site 137722012248 Walker B; other site 137722012249 D-loop; other site 137722012250 H-loop/switch region; other site 137722012251 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722012252 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 137722012253 putative active site [active] 137722012254 putative NTP binding site [chemical binding]; other site 137722012255 putative nucleic acid binding site [nucleotide binding]; other site 137722012256 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 137722012257 dimer interface [polypeptide binding]; other site 137722012258 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 137722012259 catalytic nucleophile [active] 137722012260 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 137722012261 SxDxEG motif; other site 137722012262 active site 137722012263 metal binding site [ion binding]; metal-binding site 137722012264 homopentamer interface [polypeptide binding]; other site 137722012265 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 137722012266 homodimer interface [polypeptide binding]; other site 137722012267 homotetramer interface [polypeptide binding]; other site 137722012268 active site pocket [active] 137722012269 cleavage site 137722012270 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 137722012271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012272 dimer interface [polypeptide binding]; other site 137722012273 ABC-ATPase subunit interface; other site 137722012274 putative PBP binding loops; other site 137722012275 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 137722012276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012277 dimer interface [polypeptide binding]; other site 137722012278 conserved gate region; other site 137722012279 putative PBP binding loops; other site 137722012280 ABC-ATPase subunit interface; other site 137722012281 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 137722012282 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 137722012283 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 137722012284 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722012285 Walker A/P-loop; other site 137722012286 ATP binding site [chemical binding]; other site 137722012287 Q-loop/lid; other site 137722012288 ABC transporter signature motif; other site 137722012289 Walker B; other site 137722012290 D-loop; other site 137722012291 H-loop/switch region; other site 137722012292 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 137722012293 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722012294 Walker A/P-loop; other site 137722012295 ATP binding site [chemical binding]; other site 137722012296 Q-loop/lid; other site 137722012297 ABC transporter signature motif; other site 137722012298 Walker B; other site 137722012299 D-loop; other site 137722012300 H-loop/switch region; other site 137722012301 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722012302 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 137722012303 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 137722012304 homodimer interface [polypeptide binding]; other site 137722012305 substrate-cofactor binding pocket; other site 137722012306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722012307 catalytic residue [active] 137722012308 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 137722012309 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 137722012310 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 137722012311 putative active site [active] 137722012312 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 137722012313 FliG C-terminal domain; Region: FliG_C; pfam01706 137722012314 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722012315 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722012316 metal binding site [ion binding]; metal-binding site 137722012317 active site 137722012318 I-site; other site 137722012319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722012320 D-galactonate transporter; Region: 2A0114; TIGR00893 137722012321 putative substrate translocation pore; other site 137722012322 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 137722012323 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 137722012324 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 137722012325 mannonate dehydratase; Provisional; Region: PRK03906 137722012326 mannonate dehydratase; Region: uxuA; TIGR00695 137722012327 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 137722012328 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 137722012329 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 137722012330 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 137722012331 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 137722012332 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722012333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 137722012334 dimerization interface [polypeptide binding]; other site 137722012335 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722012336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722012337 dimer interface [polypeptide binding]; other site 137722012338 putative CheW interface [polypeptide binding]; other site 137722012339 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 137722012340 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722012341 substrate binding pocket [chemical binding]; other site 137722012342 membrane-bound complex binding site; other site 137722012343 hinge residues; other site 137722012344 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 137722012345 Serine hydrolase; Region: Ser_hydrolase; pfam06821 137722012346 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 137722012347 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 137722012348 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 137722012349 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 137722012350 Coenzyme A transferase; Region: CoA_trans; cl17247 137722012351 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 137722012352 citrate lyase subunit gamma; Provisional; Region: PRK13253 137722012353 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 137722012354 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 137722012355 active site 137722012356 nucleotide binding site [chemical binding]; other site 137722012357 HIGH motif; other site 137722012358 KMSKS motif; other site 137722012359 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 137722012360 Malic enzyme, N-terminal domain; Region: malic; pfam00390 137722012361 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 137722012362 putative NAD(P) binding site [chemical binding]; other site 137722012363 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 137722012364 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 137722012365 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722012366 HAMP domain; Region: HAMP; pfam00672 137722012367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722012368 dimer interface [polypeptide binding]; other site 137722012369 phosphorylation site [posttranslational modification] 137722012370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722012371 ATP binding site [chemical binding]; other site 137722012372 Mg2+ binding site [ion binding]; other site 137722012373 G-X-G motif; other site 137722012374 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 137722012375 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 137722012376 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722012377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722012378 active site 137722012379 phosphorylation site [posttranslational modification] 137722012380 intermolecular recognition site; other site 137722012381 dimerization interface [polypeptide binding]; other site 137722012382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722012383 DNA binding site [nucleotide binding] 137722012384 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 137722012385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722012386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722012387 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 137722012388 DctM-like transporters; Region: DctM; pfam06808 137722012389 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 137722012390 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 137722012391 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 137722012392 inhibitor site; inhibition site 137722012393 active site 137722012394 dimer interface [polypeptide binding]; other site 137722012395 catalytic residue [active] 137722012396 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 137722012397 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 137722012398 Transcriptional regulators [Transcription]; Region: PurR; COG1609 137722012399 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 137722012400 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 137722012401 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 137722012402 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 137722012403 N-terminal plug; other site 137722012404 ligand-binding site [chemical binding]; other site 137722012405 CHAT domain; Region: CHAT; pfam12770 137722012406 CHASE2 domain; Region: CHASE2; cl01732 137722012407 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 137722012408 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722012409 putative CheW interface [polypeptide binding]; other site 137722012410 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 137722012411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722012412 active site 137722012413 phosphorylation site [posttranslational modification] 137722012414 intermolecular recognition site; other site 137722012415 dimerization interface [polypeptide binding]; other site 137722012416 CheB methylesterase; Region: CheB_methylest; pfam01339 137722012417 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 137722012418 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 137722012419 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 137722012420 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722012421 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722012422 dimer interface [polypeptide binding]; other site 137722012423 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 137722012424 putative CheW interface [polypeptide binding]; other site 137722012425 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 137722012426 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 137722012427 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 137722012428 putative binding surface; other site 137722012429 active site 137722012430 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 137722012431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722012432 ATP binding site [chemical binding]; other site 137722012433 Mg2+ binding site [ion binding]; other site 137722012434 G-X-G motif; other site 137722012435 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 137722012436 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722012437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722012438 active site 137722012439 phosphorylation site [posttranslational modification] 137722012440 intermolecular recognition site; other site 137722012441 dimerization interface [polypeptide binding]; other site 137722012442 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 137722012443 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 137722012444 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 137722012445 homotrimer interaction site [polypeptide binding]; other site 137722012446 putative active site [active] 137722012447 ornithine cyclodeaminase; Validated; Region: PRK06199 137722012448 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 137722012449 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 137722012450 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 137722012451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722012452 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722012453 MarR family; Region: MarR; pfam01047 137722012454 Flavin Reductases; Region: FlaRed; cl00801 137722012455 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 137722012456 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 137722012457 FMN-binding pocket [chemical binding]; other site 137722012458 flavin binding motif; other site 137722012459 phosphate binding motif [ion binding]; other site 137722012460 beta-alpha-beta structure motif; other site 137722012461 NAD binding pocket [chemical binding]; other site 137722012462 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722012463 catalytic loop [active] 137722012464 iron binding site [ion binding]; other site 137722012465 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 137722012466 classical (c) SDRs; Region: SDR_c; cd05233 137722012467 NAD(P) binding site [chemical binding]; other site 137722012468 active site 137722012469 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 137722012470 inter-subunit interface; other site 137722012471 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 137722012472 [2Fe-2S] cluster binding site [ion binding]; other site 137722012473 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 137722012474 putative alpha subunit interface [polypeptide binding]; other site 137722012475 putative active site [active] 137722012476 putative substrate binding site [chemical binding]; other site 137722012477 Fe binding site [ion binding]; other site 137722012478 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722012479 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722012480 SnoaL-like domain; Region: SnoaL_4; pfam13577 137722012481 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722012482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722012483 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 137722012484 putative effector binding pocket; other site 137722012485 dimerization interface [polypeptide binding]; other site 137722012486 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 137722012487 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 137722012488 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 137722012489 active site 137722012490 dimer interface [polypeptide binding]; other site 137722012491 metal binding site [ion binding]; metal-binding site 137722012492 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 137722012493 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 137722012494 dimer interface [polypeptide binding]; other site 137722012495 active site 137722012496 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 137722012497 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 137722012498 NAD(P) binding site [chemical binding]; other site 137722012499 catalytic residues [active] 137722012500 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722012501 PAS domain; Region: PAS_9; pfam13426 137722012502 putative active site [active] 137722012503 heme pocket [chemical binding]; other site 137722012504 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722012505 putative CheW interface [polypeptide binding]; other site 137722012506 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 137722012507 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 137722012508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722012509 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 137722012510 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 137722012511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722012512 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722012513 putative substrate translocation pore; other site 137722012514 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 137722012515 Amidase; Region: Amidase; pfam01425 137722012516 transcriptional regulator EutR; Provisional; Region: PRK10130 137722012517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722012518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722012519 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 137722012520 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 137722012521 active site 137722012522 catalytic residues [active] 137722012523 pyruvate kinase; Provisional; Region: PRK06247 137722012524 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 137722012525 domain interfaces; other site 137722012526 active site 137722012527 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722012528 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722012529 putative DNA binding site [nucleotide binding]; other site 137722012530 putative Zn2+ binding site [ion binding]; other site 137722012531 AsnC family; Region: AsnC_trans_reg; pfam01037 137722012532 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 137722012533 allophanate hydrolase; Provisional; Region: PRK08186 137722012534 Amidase; Region: Amidase; cl11426 137722012535 amidase; Provisional; Region: PRK09201 137722012536 Amidase; Region: Amidase; cl11426 137722012537 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 137722012538 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722012539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722012540 DNA-binding site [nucleotide binding]; DNA binding site 137722012541 FCD domain; Region: FCD; pfam07729 137722012542 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 137722012543 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 137722012544 putative ligand binding site [chemical binding]; other site 137722012545 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 137722012546 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722012547 TM-ABC transporter signature motif; other site 137722012548 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722012549 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 137722012550 TM-ABC transporter signature motif; other site 137722012551 Isochorismatase family; Region: Isochorismatase; pfam00857 137722012552 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 137722012553 catalytic triad [active] 137722012554 conserved cis-peptide bond; other site 137722012555 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 137722012556 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 137722012557 Walker A/P-loop; other site 137722012558 ATP binding site [chemical binding]; other site 137722012559 Q-loop/lid; other site 137722012560 ABC transporter signature motif; other site 137722012561 Walker B; other site 137722012562 D-loop; other site 137722012563 H-loop/switch region; other site 137722012564 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 137722012565 Isochorismatase family; Region: Isochorismatase; pfam00857 137722012566 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 137722012567 catalytic triad [active] 137722012568 conserved cis-peptide bond; other site 137722012569 benzoate transport; Region: 2A0115; TIGR00895 137722012570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722012571 putative substrate translocation pore; other site 137722012572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722012573 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 137722012574 Cupin domain; Region: Cupin_2; pfam07883 137722012575 Cupin domain; Region: Cupin_2; cl17218 137722012576 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 137722012577 [2Fe-2S] cluster binding site [ion binding]; other site 137722012578 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 137722012579 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 137722012580 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 137722012581 iron-sulfur cluster [ion binding]; other site 137722012582 [2Fe-2S] cluster binding site [ion binding]; other site 137722012583 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 137722012584 putative alpha subunit interface [polypeptide binding]; other site 137722012585 putative active site [active] 137722012586 putative substrate binding site [chemical binding]; other site 137722012587 Fe binding site [ion binding]; other site 137722012588 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 137722012589 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 137722012590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 137722012591 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 137722012592 Transcriptional regulator [Transcription]; Region: IclR; COG1414 137722012593 Bacterial transcriptional regulator; Region: IclR; pfam01614 137722012594 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 137722012595 maleylacetoacetate isomerase; Region: maiA; TIGR01262 137722012596 C-terminal domain interface [polypeptide binding]; other site 137722012597 GSH binding site (G-site) [chemical binding]; other site 137722012598 putative dimer interface [polypeptide binding]; other site 137722012599 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 137722012600 dimer interface [polypeptide binding]; other site 137722012601 N-terminal domain interface [polypeptide binding]; other site 137722012602 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 137722012603 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 137722012604 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 137722012605 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722012606 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722012607 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 137722012608 PLD-like domain; Region: PLDc_2; pfam13091 137722012609 putative active site [active] 137722012610 catalytic site [active] 137722012611 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 137722012612 PLD-like domain; Region: PLDc_2; pfam13091 137722012613 putative active site [active] 137722012614 catalytic site [active] 137722012615 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 137722012616 hypothetical protein; Validated; Region: PRK06201 137722012617 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 137722012618 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 137722012619 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 137722012620 ligand binding site [chemical binding]; other site 137722012621 NAD binding site [chemical binding]; other site 137722012622 dimerization interface [polypeptide binding]; other site 137722012623 catalytic site [active] 137722012624 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 137722012625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722012626 putative substrate translocation pore; other site 137722012627 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 137722012628 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 137722012629 active site 137722012630 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 137722012631 Strictosidine synthase; Region: Str_synth; pfam03088 137722012632 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 137722012633 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 137722012634 active site 137722012635 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 137722012636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722012637 putative substrate translocation pore; other site 137722012638 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722012639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722012640 Walker A/P-loop; other site 137722012641 ATP binding site [chemical binding]; other site 137722012642 Q-loop/lid; other site 137722012643 ABC transporter signature motif; other site 137722012644 Walker B; other site 137722012645 D-loop; other site 137722012646 H-loop/switch region; other site 137722012647 TOBE domain; Region: TOBE_2; pfam08402 137722012648 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722012649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012650 dimer interface [polypeptide binding]; other site 137722012651 conserved gate region; other site 137722012652 putative PBP binding loops; other site 137722012653 ABC-ATPase subunit interface; other site 137722012654 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 137722012655 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 137722012656 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 137722012657 NIPSNAP; Region: NIPSNAP; pfam07978 137722012658 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 137722012659 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 137722012660 NAD(P) binding site [chemical binding]; other site 137722012661 catalytic residues [active] 137722012662 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 137722012663 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 137722012664 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 137722012665 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 137722012666 Amino acid synthesis; Region: AA_synth; pfam06684 137722012667 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722012668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722012669 DNA-binding site [nucleotide binding]; DNA binding site 137722012670 FCD domain; Region: FCD; pfam07729 137722012671 Integrase core domain; Region: rve_2; pfam13333 137722012672 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 137722012673 Cupin domain; Region: Cupin_2; pfam07883 137722012674 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 137722012675 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 137722012676 putative active site [active] 137722012677 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 137722012678 domain_subunit interface; other site 137722012679 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 137722012680 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 137722012681 active site 137722012682 FMN binding site [chemical binding]; other site 137722012683 substrate binding site [chemical binding]; other site 137722012684 3Fe-4S cluster binding site [ion binding]; other site 137722012685 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 137722012686 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 137722012687 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 137722012688 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 137722012689 hydroxyglutarate oxidase; Provisional; Region: PRK11728 137722012690 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 137722012691 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 137722012692 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 137722012693 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 137722012694 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 137722012695 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 137722012696 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 137722012697 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 137722012698 putative active site [active] 137722012699 putative substrate binding site [chemical binding]; other site 137722012700 putative cosubstrate binding site; other site 137722012701 catalytic site [active] 137722012702 Dihydroneopterin aldolase; Region: FolB; smart00905 137722012703 active site 137722012704 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 137722012705 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 137722012706 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 137722012707 homodimer interface [polypeptide binding]; other site 137722012708 NADP binding site [chemical binding]; other site 137722012709 substrate binding site [chemical binding]; other site 137722012710 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 137722012711 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 137722012712 PYR/PP interface [polypeptide binding]; other site 137722012713 dimer interface [polypeptide binding]; other site 137722012714 TPP binding site [chemical binding]; other site 137722012715 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 137722012716 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 137722012717 TPP-binding site [chemical binding]; other site 137722012718 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 137722012719 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 137722012720 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 137722012721 Walker A/P-loop; other site 137722012722 ATP binding site [chemical binding]; other site 137722012723 Q-loop/lid; other site 137722012724 ABC transporter signature motif; other site 137722012725 Walker B; other site 137722012726 D-loop; other site 137722012727 H-loop/switch region; other site 137722012728 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 137722012729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012730 dimer interface [polypeptide binding]; other site 137722012731 conserved gate region; other site 137722012732 putative PBP binding loops; other site 137722012733 ABC-ATPase subunit interface; other site 137722012734 hypothetical protein; Provisional; Region: PRK07475 137722012735 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722012736 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722012737 substrate binding pocket [chemical binding]; other site 137722012738 membrane-bound complex binding site; other site 137722012739 hinge residues; other site 137722012740 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 137722012741 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722012742 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722012743 dimerization interface [polypeptide binding]; other site 137722012744 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 137722012745 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 137722012746 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 137722012747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722012748 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 137722012749 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 137722012750 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 137722012751 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 137722012752 putative NAD(P) binding site [chemical binding]; other site 137722012753 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 137722012754 YcaO-like family; Region: YcaO; pfam02624 137722012755 Uncharacterized conserved protein [Function unknown]; Region: COG3482 137722012756 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 137722012757 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 137722012758 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722012759 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722012760 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 137722012761 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 137722012762 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 137722012763 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 137722012764 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 137722012765 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 137722012766 Cupin superfamily protein; Region: Cupin_4; pfam08007 137722012767 Cupin-like domain; Region: Cupin_8; pfam13621 137722012768 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 137722012769 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722012770 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722012771 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 137722012772 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 137722012773 putative active site [active] 137722012774 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 137722012775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722012776 Walker A/P-loop; other site 137722012777 ATP binding site [chemical binding]; other site 137722012778 Q-loop/lid; other site 137722012779 ABC transporter signature motif; other site 137722012780 Walker B; other site 137722012781 D-loop; other site 137722012782 H-loop/switch region; other site 137722012783 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 137722012784 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 137722012785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722012786 Walker A/P-loop; other site 137722012787 ATP binding site [chemical binding]; other site 137722012788 Q-loop/lid; other site 137722012789 ABC transporter signature motif; other site 137722012790 Walker B; other site 137722012791 D-loop; other site 137722012792 H-loop/switch region; other site 137722012793 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 137722012794 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 137722012795 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 137722012796 phosphogluconate dehydratase; Validated; Region: PRK09054 137722012797 6-phosphogluconate dehydratase; Region: edd; TIGR01196 137722012798 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 137722012799 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 137722012800 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 137722012801 putative active site [active] 137722012802 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 137722012803 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722012804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722012805 active site 137722012806 phosphorylation site [posttranslational modification] 137722012807 intermolecular recognition site; other site 137722012808 dimerization interface [polypeptide binding]; other site 137722012809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722012810 DNA binding residues [nucleotide binding] 137722012811 dimerization interface [polypeptide binding]; other site 137722012812 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 137722012813 active site residue [active] 137722012814 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 137722012815 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 137722012816 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 137722012817 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 137722012818 coenzyme PQQ biosynthesis enzyme PqqE; Region: PQQ_syn_pqqE; TIGR02109 137722012819 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722012820 FeS/SAM binding site; other site 137722012821 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 137722012822 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722012823 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722012824 putative DNA binding site [nucleotide binding]; other site 137722012825 putative Zn2+ binding site [ion binding]; other site 137722012826 AsnC family; Region: AsnC_trans_reg; pfam01037 137722012827 Isochorismatase family; Region: Isochorismatase; pfam00857 137722012828 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 137722012829 catalytic triad [active] 137722012830 conserved cis-peptide bond; other site 137722012831 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 137722012832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012833 dimer interface [polypeptide binding]; other site 137722012834 conserved gate region; other site 137722012835 ABC-ATPase subunit interface; other site 137722012836 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 137722012837 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 137722012838 Walker A/P-loop; other site 137722012839 ATP binding site [chemical binding]; other site 137722012840 Q-loop/lid; other site 137722012841 ABC transporter signature motif; other site 137722012842 Walker B; other site 137722012843 D-loop; other site 137722012844 H-loop/switch region; other site 137722012845 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 137722012846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012847 putative PBP binding loops; other site 137722012848 ABC-ATPase subunit interface; other site 137722012849 Protein of unknown function (DUF330); Region: DUF330; pfam03886 137722012850 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 137722012851 mce related protein; Region: MCE; pfam02470 137722012852 mce related protein; Region: MCE; pfam02470 137722012853 mce related protein; Region: MCE; pfam02470 137722012854 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 137722012855 Paraquat-inducible protein A; Region: PqiA; pfam04403 137722012856 Paraquat-inducible protein A; Region: PqiA; pfam04403 137722012857 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 137722012858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722012859 DNA-binding site [nucleotide binding]; DNA binding site 137722012860 UTRA domain; Region: UTRA; pfam07702 137722012861 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722012862 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722012863 substrate binding pocket [chemical binding]; other site 137722012864 membrane-bound complex binding site; other site 137722012865 hinge residues; other site 137722012866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 137722012867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012868 dimer interface [polypeptide binding]; other site 137722012869 ABC-ATPase subunit interface; other site 137722012870 putative PBP binding loops; other site 137722012871 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 137722012872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012873 dimer interface [polypeptide binding]; other site 137722012874 conserved gate region; other site 137722012875 putative PBP binding loops; other site 137722012876 ABC-ATPase subunit interface; other site 137722012877 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 137722012878 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 137722012879 Walker A/P-loop; other site 137722012880 ATP binding site [chemical binding]; other site 137722012881 Q-loop/lid; other site 137722012882 ABC transporter signature motif; other site 137722012883 Walker B; other site 137722012884 D-loop; other site 137722012885 H-loop/switch region; other site 137722012886 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722012887 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722012888 dimer interface [polypeptide binding]; other site 137722012889 putative CheW interface [polypeptide binding]; other site 137722012890 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 137722012891 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722012892 metal binding site [ion binding]; metal-binding site 137722012893 active site 137722012894 I-site; other site 137722012895 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722012896 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 137722012897 dimerization interface [polypeptide binding]; other site 137722012898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722012899 ATP binding site [chemical binding]; other site 137722012900 Mg2+ binding site [ion binding]; other site 137722012901 G-X-G motif; other site 137722012902 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 137722012903 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 137722012904 ligand binding site [chemical binding]; other site 137722012905 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722012906 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722012907 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722012908 dimer interface [polypeptide binding]; other site 137722012909 putative CheW interface [polypeptide binding]; other site 137722012910 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 137722012911 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 137722012912 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 137722012913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012914 putative PBP binding loops; other site 137722012915 ABC-ATPase subunit interface; other site 137722012916 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722012917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722012918 Walker A/P-loop; other site 137722012919 ATP binding site [chemical binding]; other site 137722012920 Q-loop/lid; other site 137722012921 ABC transporter signature motif; other site 137722012922 Walker B; other site 137722012923 D-loop; other site 137722012924 H-loop/switch region; other site 137722012925 TOBE domain; Region: TOBE_2; pfam08402 137722012926 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 137722012927 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 137722012928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012929 conserved gate region; other site 137722012930 putative PBP binding loops; other site 137722012931 ABC-ATPase subunit interface; other site 137722012932 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 137722012933 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 137722012934 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722012935 Walker A/P-loop; other site 137722012936 ATP binding site [chemical binding]; other site 137722012937 Q-loop/lid; other site 137722012938 ABC transporter signature motif; other site 137722012939 Walker B; other site 137722012940 D-loop; other site 137722012941 H-loop/switch region; other site 137722012942 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 137722012943 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 137722012944 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722012945 Walker A/P-loop; other site 137722012946 ATP binding site [chemical binding]; other site 137722012947 Q-loop/lid; other site 137722012948 ABC transporter signature motif; other site 137722012949 Walker B; other site 137722012950 D-loop; other site 137722012951 H-loop/switch region; other site 137722012952 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722012953 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 137722012954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012955 dimer interface [polypeptide binding]; other site 137722012956 conserved gate region; other site 137722012957 putative PBP binding loops; other site 137722012958 ABC-ATPase subunit interface; other site 137722012959 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 137722012960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722012961 dimer interface [polypeptide binding]; other site 137722012962 conserved gate region; other site 137722012963 putative PBP binding loops; other site 137722012964 ABC-ATPase subunit interface; other site 137722012965 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 137722012966 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 137722012967 Sulfatase; Region: Sulfatase; cl17466 137722012968 Sulfatase; Region: Sulfatase; cl17466 137722012969 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 137722012970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722012971 active site 137722012972 phosphorylation site [posttranslational modification] 137722012973 intermolecular recognition site; other site 137722012974 dimerization interface [polypeptide binding]; other site 137722012975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722012976 Walker A motif; other site 137722012977 ATP binding site [chemical binding]; other site 137722012978 Walker B motif; other site 137722012979 arginine finger; other site 137722012980 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722012981 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722012982 dimerization interface [polypeptide binding]; other site 137722012983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722012984 dimer interface [polypeptide binding]; other site 137722012985 phosphorylation site [posttranslational modification] 137722012986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722012987 ATP binding site [chemical binding]; other site 137722012988 Mg2+ binding site [ion binding]; other site 137722012989 G-X-G motif; other site 137722012990 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 137722012991 Esterase/lipase [General function prediction only]; Region: COG1647 137722012992 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 137722012993 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 137722012994 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 137722012995 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 137722012996 inhibitor-cofactor binding pocket; inhibition site 137722012997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722012998 catalytic residue [active] 137722012999 MltA-interacting protein MipA; Region: MipA; cl01504 137722013000 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 137722013001 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 137722013002 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 137722013003 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722013004 catalytic residue [active] 137722013005 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 137722013006 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 137722013007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722013008 motif II; other site 137722013009 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 137722013010 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722013011 catalytic residue [active] 137722013012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722013013 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 137722013014 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722013015 dimerization interface [polypeptide binding]; other site 137722013016 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 137722013017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 137722013018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722013019 dimer interface [polypeptide binding]; other site 137722013020 conserved gate region; other site 137722013021 putative PBP binding loops; other site 137722013022 ABC-ATPase subunit interface; other site 137722013023 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 137722013024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722013025 Walker A/P-loop; other site 137722013026 ATP binding site [chemical binding]; other site 137722013027 Q-loop/lid; other site 137722013028 ABC transporter signature motif; other site 137722013029 Walker B; other site 137722013030 D-loop; other site 137722013031 H-loop/switch region; other site 137722013032 TOBE domain; Region: TOBE_2; pfam08402 137722013033 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 137722013034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722013035 PAS fold; Region: PAS_3; pfam08447 137722013036 putative active site [active] 137722013037 heme pocket [chemical binding]; other site 137722013038 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722013039 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722013040 metal binding site [ion binding]; metal-binding site 137722013041 active site 137722013042 I-site; other site 137722013043 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722013044 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 137722013045 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722013046 dimer interface [polypeptide binding]; other site 137722013047 putative CheW interface [polypeptide binding]; other site 137722013048 Predicted membrane protein [Function unknown]; Region: COG2259 137722013049 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 137722013050 hypothetical protein; Provisional; Region: PRK05409 137722013051 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 137722013052 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 137722013053 putative catalytic residues [active] 137722013054 LysR family transcriptional regulator; Provisional; Region: PRK14997 137722013055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722013056 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 137722013057 putative effector binding pocket; other site 137722013058 dimerization interface [polypeptide binding]; other site 137722013059 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 137722013060 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 137722013061 active site 137722013062 catalytic tetrad [active] 137722013063 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722013064 MarR family; Region: MarR_2; pfam12802 137722013065 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 137722013066 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722013067 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722013068 Fusaric acid resistance protein family; Region: FUSC; pfam04632 137722013069 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 137722013070 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 137722013071 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 137722013072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722013073 putative active site [active] 137722013074 heme pocket [chemical binding]; other site 137722013075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722013076 dimer interface [polypeptide binding]; other site 137722013077 phosphorylation site [posttranslational modification] 137722013078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722013079 ATP binding site [chemical binding]; other site 137722013080 Mg2+ binding site [ion binding]; other site 137722013081 G-X-G motif; other site 137722013082 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 137722013083 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 137722013084 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 137722013085 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722013086 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013087 DDE superfamily endonuclease; Region: DDE_5; cl17874 137722013088 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 137722013089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 137722013090 Transposase; Region: DDE_Tnp_ISL3; pfam01610 137722013091 Transposase; Region: DDE_Tnp_ISL3; pfam01610 137722013092 Predicted transcriptional regulators [Transcription]; Region: COG1733 137722013093 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 137722013094 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722013095 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013096 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 137722013097 putative NAD(P) binding site [chemical binding]; other site 137722013098 dimer interface [polypeptide binding]; other site 137722013099 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722013100 short chain dehydrogenase; Provisional; Region: PRK06179 137722013101 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 137722013102 NADP binding site [chemical binding]; other site 137722013103 active site 137722013104 steroid binding site; other site 137722013105 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 137722013106 Prostaglandin dehydrogenases; Region: PGDH; cd05288 137722013107 NAD(P) binding site [chemical binding]; other site 137722013108 substrate binding site [chemical binding]; other site 137722013109 dimer interface [polypeptide binding]; other site 137722013110 acyl-CoA synthetase; Validated; Region: PRK06188 137722013111 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 137722013112 acyl-activating enzyme (AAE) consensus motif; other site 137722013113 putative AMP binding site [chemical binding]; other site 137722013114 putative active site [active] 137722013115 putative CoA binding site [chemical binding]; other site 137722013116 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 137722013117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013118 substrate binding site [chemical binding]; other site 137722013119 oxyanion hole (OAH) forming residues; other site 137722013120 trimer interface [polypeptide binding]; other site 137722013121 Uncharacterized conserved protein [Function unknown]; Region: COG3268 137722013122 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722013123 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 137722013124 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 137722013125 active site 137722013126 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 137722013127 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722013128 active site 137722013129 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 137722013130 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 137722013131 Ligand binding site [chemical binding]; other site 137722013132 Electron transfer flavoprotein domain; Region: ETF; pfam01012 137722013133 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 137722013134 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 137722013135 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 137722013136 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013137 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 137722013138 substrate binding site [chemical binding]; other site 137722013139 oxyanion hole (OAH) forming residues; other site 137722013140 trimer interface [polypeptide binding]; other site 137722013141 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 137722013142 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722013143 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722013144 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 137722013145 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 137722013146 dimer interface [polypeptide binding]; other site 137722013147 active site 137722013148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722013149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722013150 DNA binding residues [nucleotide binding] 137722013151 dimerization interface [polypeptide binding]; other site 137722013152 lipid-transfer protein; Provisional; Region: PRK08256 137722013153 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 137722013154 active site 137722013155 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 137722013156 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 137722013157 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 137722013158 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 137722013159 classical (c) SDRs; Region: SDR_c; cd05233 137722013160 NAD(P) binding site [chemical binding]; other site 137722013161 active site 137722013162 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722013163 dimerization interface [polypeptide binding]; other site 137722013164 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722013165 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722013166 dimer interface [polypeptide binding]; other site 137722013167 putative CheW interface [polypeptide binding]; other site 137722013168 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722013169 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722013170 dimer interface [polypeptide binding]; other site 137722013171 putative CheW interface [polypeptide binding]; other site 137722013172 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013173 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 137722013174 substrate binding site [chemical binding]; other site 137722013175 oxyanion hole (OAH) forming residues; other site 137722013176 trimer interface [polypeptide binding]; other site 137722013177 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 137722013178 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722013179 acyl-activating enzyme (AAE) consensus motif; other site 137722013180 AMP binding site [chemical binding]; other site 137722013181 active site 137722013182 CoA binding site [chemical binding]; other site 137722013183 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 137722013184 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722013185 catalytic loop [active] 137722013186 iron binding site [ion binding]; other site 137722013187 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 137722013188 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 137722013189 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 137722013190 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 137722013191 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 137722013192 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 137722013193 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 137722013194 putative hydrophobic ligand binding site [chemical binding]; other site 137722013195 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 137722013196 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 137722013197 Na binding site [ion binding]; other site 137722013198 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 137722013199 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 137722013200 phosphate binding site [ion binding]; other site 137722013201 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 137722013202 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 137722013203 PYR/PP interface [polypeptide binding]; other site 137722013204 dimer interface [polypeptide binding]; other site 137722013205 TPP binding site [chemical binding]; other site 137722013206 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 137722013207 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 137722013208 dimer interface [polypeptide binding]; other site 137722013209 TPP-binding site [chemical binding]; other site 137722013210 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 137722013211 Flavoprotein; Region: Flavoprotein; pfam02441 137722013212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722013213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722013214 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722013215 dimerization interface [polypeptide binding]; other site 137722013216 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 137722013217 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 137722013218 NAD(P) binding site [chemical binding]; other site 137722013219 catalytic residues [active] 137722013220 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 137722013221 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013222 substrate binding site [chemical binding]; other site 137722013223 oxyanion hole (OAH) forming residues; other site 137722013224 trimer interface [polypeptide binding]; other site 137722013225 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 137722013226 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722013227 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722013228 lipid-transfer protein; Provisional; Region: PRK08256 137722013229 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 137722013230 active site 137722013231 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 137722013232 Ligand Binding Site [chemical binding]; other site 137722013233 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 137722013234 Ligand Binding Site [chemical binding]; other site 137722013235 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 137722013236 Ligand binding site [chemical binding]; other site 137722013237 Electron transfer flavoprotein domain; Region: ETF; pfam01012 137722013238 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 137722013239 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 137722013240 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 137722013241 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 137722013242 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 137722013243 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 137722013244 catalytic site [active] 137722013245 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 137722013246 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 137722013247 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013248 substrate binding site [chemical binding]; other site 137722013249 oxyanion hole (OAH) forming residues; other site 137722013250 trimer interface [polypeptide binding]; other site 137722013251 Transcriptional regulators [Transcription]; Region: FadR; COG2186 137722013252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722013253 DNA-binding site [nucleotide binding]; DNA binding site 137722013254 FCD domain; Region: FCD; pfam07729 137722013255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722013256 dimerization interface [polypeptide binding]; other site 137722013257 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722013258 dimer interface [polypeptide binding]; other site 137722013259 putative CheW interface [polypeptide binding]; other site 137722013260 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 137722013261 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 137722013262 FMN binding site [chemical binding]; other site 137722013263 substrate binding site [chemical binding]; other site 137722013264 putative catalytic residue [active] 137722013265 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722013266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722013267 active site 137722013268 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722013269 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722013270 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013271 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 137722013272 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013273 substrate binding site [chemical binding]; other site 137722013274 oxyanion hole (OAH) forming residues; other site 137722013275 trimer interface [polypeptide binding]; other site 137722013276 short chain dehydrogenase; Provisional; Region: PRK07791 137722013277 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 137722013278 homodimer interface [polypeptide binding]; other site 137722013279 NAD binding site [chemical binding]; other site 137722013280 active site 137722013281 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722013282 Transposase; Region: HTH_Tnp_1; pfam01527 137722013283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722013284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722013285 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 137722013286 putative dimerization interface [polypeptide binding]; other site 137722013287 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 137722013288 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 137722013289 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722013290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722013291 binding surface 137722013292 Tetratricopeptide repeat; Region: TPR_16; pfam13432 137722013293 TPR motif; other site 137722013294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722013295 binding surface 137722013296 TPR motif; other site 137722013297 TPR repeat; Region: TPR_11; pfam13414 137722013298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722013299 TPR motif; other site 137722013300 Tetratricopeptide repeat; Region: TPR_12; pfam13424 137722013301 binding surface 137722013302 PAS fold; Region: PAS; pfam00989 137722013303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722013304 putative active site [active] 137722013305 heme pocket [chemical binding]; other site 137722013306 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 137722013307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722013308 putative active site [active] 137722013309 heme pocket [chemical binding]; other site 137722013310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722013311 dimer interface [polypeptide binding]; other site 137722013312 phosphorylation site [posttranslational modification] 137722013313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722013314 ATP binding site [chemical binding]; other site 137722013315 Mg2+ binding site [ion binding]; other site 137722013316 G-X-G motif; other site 137722013317 Helix-turn-helix domain; Region: HTH_36; pfam13730 137722013318 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722013319 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 137722013320 Walker A/P-loop; other site 137722013321 ATP binding site [chemical binding]; other site 137722013322 Q-loop/lid; other site 137722013323 ABC transporter signature motif; other site 137722013324 Walker B; other site 137722013325 D-loop; other site 137722013326 H-loop/switch region; other site 137722013327 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 137722013328 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722013329 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 137722013330 TM-ABC transporter signature motif; other site 137722013331 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 137722013332 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 137722013333 putative ligand binding site [chemical binding]; other site 137722013334 xylose isomerase; Provisional; Region: PRK05474 137722013335 xylose isomerase; Region: xylose_isom_A; TIGR02630 137722013336 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 137722013337 N- and C-terminal domain interface [polypeptide binding]; other site 137722013338 D-xylulose kinase; Region: XylB; TIGR01312 137722013339 active site 137722013340 MgATP binding site [chemical binding]; other site 137722013341 catalytic site [active] 137722013342 metal binding site [ion binding]; metal-binding site 137722013343 xylulose binding site [chemical binding]; other site 137722013344 homodimer interface [polypeptide binding]; other site 137722013345 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 137722013346 DNA binding site [nucleotide binding] 137722013347 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 137722013348 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 137722013349 putative ligand binding site [chemical binding]; other site 137722013350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722013351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722013352 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722013353 dimerization interface [polypeptide binding]; other site 137722013354 Uncharacterized conserved protein [Function unknown]; Region: COG2353 137722013355 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 137722013356 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 137722013357 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 137722013358 putative dimer interface [polypeptide binding]; other site 137722013359 N-terminal domain interface [polypeptide binding]; other site 137722013360 putative substrate binding pocket (H-site) [chemical binding]; other site 137722013361 putative hydrolase; Provisional; Region: PRK11460 137722013362 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 137722013363 Beta-lactamase; Region: Beta-lactamase; pfam00144 137722013364 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 137722013365 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 137722013366 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 137722013367 putative metal binding site [ion binding]; other site 137722013368 Integrase core domain; Region: rve; pfam00665 137722013369 Integrase core domain; Region: rve_2; pfam13333 137722013370 SCP-2 sterol transfer family; Region: SCP2; cl01225 137722013371 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 137722013372 Peptidase family U32; Region: Peptidase_U32; pfam01136 137722013373 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 137722013374 putative protease; Provisional; Region: PRK15447 137722013375 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 137722013376 ParB-like nuclease domain; Region: ParBc; pfam02195 137722013377 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722013378 non-specific DNA binding site [nucleotide binding]; other site 137722013379 salt bridge; other site 137722013380 sequence-specific DNA binding site [nucleotide binding]; other site 137722013381 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 137722013382 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722013383 P-loop; other site 137722013384 Magnesium ion binding site [ion binding]; other site 137722013385 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722013386 Magnesium ion binding site [ion binding]; other site 137722013387 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 137722013388 ATP-binding site [chemical binding]; other site 137722013389 Gluconate-6-phosphate binding site [chemical binding]; other site 137722013390 Shikimate kinase; Region: SKI; pfam01202 137722013391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722013392 D-galactonate transporter; Region: 2A0114; TIGR00893 137722013393 putative substrate translocation pore; other site 137722013394 Domain of unknown function (DUF386); Region: DUF386; pfam04074 137722013395 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 137722013396 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 137722013397 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 137722013398 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 137722013399 putative ligand binding site [chemical binding]; other site 137722013400 NAD binding site [chemical binding]; other site 137722013401 catalytic site [active] 137722013402 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 137722013403 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 137722013404 putative NAD(P) binding site [chemical binding]; other site 137722013405 catalytic Zn binding site [ion binding]; other site 137722013406 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 137722013407 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 137722013408 NADP binding site [chemical binding]; other site 137722013409 homodimer interface [polypeptide binding]; other site 137722013410 active site 137722013411 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 137722013412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722013413 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 137722013414 dimerization interface [polypeptide binding]; other site 137722013415 substrate binding pocket [chemical binding]; other site 137722013416 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 137722013417 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 137722013418 Mechanosensitive ion channel; Region: MS_channel; pfam00924 137722013419 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722013420 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722013421 ligand binding site [chemical binding]; other site 137722013422 flexible hinge region; other site 137722013423 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722013424 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722013425 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722013426 dimer interface [polypeptide binding]; other site 137722013427 putative CheW interface [polypeptide binding]; other site 137722013428 VacJ like lipoprotein; Region: VacJ; cl01073 137722013429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 137722013430 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722013431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722013432 Walker A/P-loop; other site 137722013433 ATP binding site [chemical binding]; other site 137722013434 Q-loop/lid; other site 137722013435 ABC transporter signature motif; other site 137722013436 Walker B; other site 137722013437 D-loop; other site 137722013438 H-loop/switch region; other site 137722013439 isocitrate lyase; Region: PLN02892 137722013440 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 137722013441 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 137722013442 ligand binding site [chemical binding]; other site 137722013443 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 137722013444 Mechanosensitive ion channel; Region: MS_channel; pfam00924 137722013445 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722013446 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722013447 ligand binding site [chemical binding]; other site 137722013448 flexible hinge region; other site 137722013449 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 137722013450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722013451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722013452 putative substrate translocation pore; other site 137722013453 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 137722013454 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 137722013455 catalytic residue [active] 137722013456 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 137722013457 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 137722013458 TPR repeat; Region: TPR_11; pfam13414 137722013459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722013460 TPR motif; other site 137722013461 binding surface 137722013462 TPR repeat; Region: TPR_11; pfam13414 137722013463 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 137722013464 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 137722013465 peptide binding site [polypeptide binding]; other site 137722013466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 137722013467 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 137722013468 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722013469 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 137722013470 Protein export membrane protein; Region: SecD_SecF; cl14618 137722013471 Protein export membrane protein; Region: SecD_SecF; cl14618 137722013472 Bacterial SH3 domain; Region: SH3_3; pfam08239 137722013473 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 137722013474 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 137722013475 ligand binding site [chemical binding]; other site 137722013476 NAD binding site [chemical binding]; other site 137722013477 catalytic site [active] 137722013478 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722013479 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013480 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 137722013481 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 137722013482 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 137722013483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722013484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722013485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722013486 dimerization interface [polypeptide binding]; other site 137722013487 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 137722013488 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 137722013489 trimer interface [polypeptide binding]; other site 137722013490 putative metal binding site [ion binding]; other site 137722013491 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 137722013492 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 137722013493 E3 interaction surface; other site 137722013494 lipoyl attachment site [posttranslational modification]; other site 137722013495 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722013496 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722013497 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013498 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722013499 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722013500 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013501 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722013502 MULE transposase domain; Region: MULE; pfam10551 137722013503 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013504 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722013505 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013506 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722013508 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722013509 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013510 Integrase core domain; Region: rve; pfam00665 137722013511 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722013512 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722013513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 137722013514 Homeodomain-like domain; Region: HTH_32; pfam13565 137722013515 Integrase core domain; Region: rve; pfam00665 137722013516 Integrase core domain; Region: rve_3; pfam13683 137722013517 HTH-like domain; Region: HTH_21; pfam13276 137722013518 Transposase; Region: HTH_Tnp_1; cl17663 137722013519 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722013520 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722013521 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013522 HD domain; Region: HD_4; pfam13328 137722013523 Transposase; Region: HTH_Tnp_IS630; pfam01710 137722013524 MULE transposase domain; Region: MULE; pfam10551 137722013525 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722013526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722013527 Walker A motif; other site 137722013528 ATP binding site [chemical binding]; other site 137722013529 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722013530 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722013531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722013532 Integrase core domain; Region: rve; pfam00665 137722013533 Homeodomain-like domain; Region: HTH_32; pfam13565 137722013534 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 137722013535 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722013536 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722013537 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 137722013538 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 137722013539 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 137722013540 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 137722013541 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 137722013542 putative active site [active] 137722013543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722013544 dimerization interface [polypeptide binding]; other site 137722013545 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722013546 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722013547 dimer interface [polypeptide binding]; other site 137722013548 putative CheW interface [polypeptide binding]; other site 137722013549 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 137722013550 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 137722013551 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 137722013552 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 137722013553 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 137722013554 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 137722013555 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722013556 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 137722013557 TM-ABC transporter signature motif; other site 137722013558 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 137722013559 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 137722013560 Walker A/P-loop; other site 137722013561 ATP binding site [chemical binding]; other site 137722013562 Q-loop/lid; other site 137722013563 ABC transporter signature motif; other site 137722013564 Walker B; other site 137722013565 D-loop; other site 137722013566 H-loop/switch region; other site 137722013567 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 137722013568 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 137722013569 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 137722013570 ligand binding site [chemical binding]; other site 137722013571 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 137722013572 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 137722013573 tetrameric interface [polypeptide binding]; other site 137722013574 NAD binding site [chemical binding]; other site 137722013575 catalytic residues [active] 137722013576 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 137722013577 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 137722013578 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 137722013579 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 137722013580 PYR/PP interface [polypeptide binding]; other site 137722013581 dimer interface [polypeptide binding]; other site 137722013582 TPP binding site [chemical binding]; other site 137722013583 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 137722013584 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 137722013585 TPP-binding site [chemical binding]; other site 137722013586 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 137722013587 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 137722013588 substrate binding site [chemical binding]; other site 137722013589 ATP binding site [chemical binding]; other site 137722013590 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 137722013591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 137722013592 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 137722013593 Outer membrane efflux protein; Region: OEP; pfam02321 137722013594 Outer membrane efflux protein; Region: OEP; pfam02321 137722013595 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 137722013596 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722013597 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722013598 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 137722013599 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 137722013600 Walker A/P-loop; other site 137722013601 ATP binding site [chemical binding]; other site 137722013602 Q-loop/lid; other site 137722013603 ABC transporter signature motif; other site 137722013604 Walker B; other site 137722013605 D-loop; other site 137722013606 H-loop/switch region; other site 137722013607 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 137722013608 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 137722013609 ligand binding site [chemical binding]; other site 137722013610 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 137722013611 Mechanosensitive ion channel; Region: MS_channel; pfam00924 137722013612 VCBS repeat; Region: VCBS_repeat; TIGR01965 137722013613 VCBS repeat; Region: VCBS_repeat; TIGR01965 137722013614 VCBS repeat; Region: VCBS_repeat; TIGR01965 137722013615 VCBS repeat; Region: VCBS_repeat; TIGR01965 137722013616 VCBS repeat; Region: VCBS_repeat; TIGR01965 137722013617 VCBS repeat; Region: VCBS_repeat; TIGR01965 137722013618 VCBS repeat; Region: VCBS_repeat; TIGR01965 137722013619 VCBS repeat; Region: VCBS_repeat; TIGR01965 137722013620 Transposase; Region: HTH_Tnp_1; cl17663 137722013621 MULE transposase domain; Region: MULE; pfam10551 137722013622 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 137722013623 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722013624 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722013625 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722013626 MULE transposase domain; Region: MULE; pfam10551 137722013627 DDE superfamily endonuclease; Region: DDE_5; cl17874 137722013628 DDE superfamily endonuclease; Region: DDE_5; cl17874 137722013629 Transcriptional regulator [Transcription]; Region: IclR; COG1414 137722013630 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 137722013631 Bacterial transcriptional regulator; Region: IclR; pfam01614 137722013632 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013633 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013634 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722013635 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013636 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722013637 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722013638 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013639 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722013640 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722013641 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722013642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722013643 Walker A motif; other site 137722013644 ATP binding site [chemical binding]; other site 137722013645 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722013646 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722013647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722013648 Integrase core domain; Region: rve; pfam00665 137722013649 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722013650 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722013651 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722013652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722013653 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722013654 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722013655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722013656 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722013657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722013658 Transposase; Region: HTH_Tnp_1; pfam01527 137722013659 Homeodomain-like domain; Region: HTH_32; pfam13565 137722013660 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722013661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 137722013662 Homeodomain-like domain; Region: HTH_32; pfam13565 137722013663 Integrase core domain; Region: rve; pfam00665 137722013664 Integrase core domain; Region: rve_3; pfam13683 137722013665 HTH-like domain; Region: HTH_21; pfam13276 137722013666 Integrase core domain; Region: rve; pfam00665 137722013667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722013668 Transposase; Region: HTH_Tnp_1; pfam01527 137722013669 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 137722013670 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 137722013671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722013672 NAD(P) binding site [chemical binding]; other site 137722013673 active site 137722013674 classical (c) SDRs; Region: SDR_c; cd05233 137722013675 NAD(P) binding site [chemical binding]; other site 137722013676 active site 137722013677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722013678 NAD(P) binding site [chemical binding]; other site 137722013679 active site 137722013680 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 137722013681 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 137722013682 putative active site [active] 137722013683 putative FMN binding site [chemical binding]; other site 137722013684 putative substrate binding site [chemical binding]; other site 137722013685 putative catalytic residue [active] 137722013686 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 137722013687 Predicted oxidoreductase [General function prediction only]; Region: COG3573 137722013688 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 137722013689 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722013690 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 137722013691 acyl-activating enzyme (AAE) consensus motif; other site 137722013692 acyl-activating enzyme (AAE) consensus motif; other site 137722013693 putative AMP binding site [chemical binding]; other site 137722013694 putative active site [active] 137722013695 putative CoA binding site [chemical binding]; other site 137722013696 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 137722013697 E3 interaction surface; other site 137722013698 lipoyl attachment site [posttranslational modification]; other site 137722013699 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 137722013700 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 137722013701 alpha subunit interface [polypeptide binding]; other site 137722013702 TPP binding site [chemical binding]; other site 137722013703 heterodimer interface [polypeptide binding]; other site 137722013704 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 137722013705 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 137722013706 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 137722013707 tetramer interface [polypeptide binding]; other site 137722013708 TPP-binding site [chemical binding]; other site 137722013709 heterodimer interface [polypeptide binding]; other site 137722013710 phosphorylation loop region [posttranslational modification] 137722013711 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 137722013712 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 137722013713 [2Fe-2S] cluster binding site [ion binding]; other site 137722013714 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 137722013715 putative alpha subunit interface [polypeptide binding]; other site 137722013716 putative active site [active] 137722013717 putative substrate binding site [chemical binding]; other site 137722013718 Fe binding site [ion binding]; other site 137722013719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722013720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722013721 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 137722013722 Rubredoxin [Energy production and conversion]; Region: COG1773 137722013723 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 137722013724 iron binding site [ion binding]; other site 137722013725 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 137722013726 Beta-lactamase; Region: Beta-lactamase; pfam00144 137722013727 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 137722013728 Cytochrome P450; Region: p450; cl12078 137722013729 choline dehydrogenase; Validated; Region: PRK02106 137722013730 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 137722013731 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 137722013732 classical (c) SDRs; Region: SDR_c; cd05233 137722013733 NAD(P) binding site [chemical binding]; other site 137722013734 active site 137722013735 HTH-like domain; Region: HTH_21; pfam13276 137722013736 Integrase core domain; Region: rve; pfam00665 137722013737 Integrase core domain; Region: rve_3; pfam13683 137722013738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722013739 Transposase; Region: HTH_Tnp_1; cl17663 137722013740 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722013741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 137722013742 Integrase core domain; Region: rve; pfam00665 137722013743 Integrase core domain; Region: rve_3; pfam13683 137722013744 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 137722013745 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 137722013746 FMN binding site [chemical binding]; other site 137722013747 substrate binding site [chemical binding]; other site 137722013748 putative catalytic residue [active] 137722013749 enoyl-CoA hydratase; Provisional; Region: PRK08260 137722013750 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013751 substrate binding site [chemical binding]; other site 137722013752 oxyanion hole (OAH) forming residues; other site 137722013753 trimer interface [polypeptide binding]; other site 137722013754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 137722013755 enoyl-CoA hydratase; Provisional; Region: PRK05864 137722013756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013757 substrate binding site [chemical binding]; other site 137722013758 oxyanion hole (OAH) forming residues; other site 137722013759 trimer interface [polypeptide binding]; other site 137722013760 enoyl-CoA hydratase; Provisional; Region: PRK12478 137722013761 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013762 substrate binding site [chemical binding]; other site 137722013763 oxyanion hole (OAH) forming residues; other site 137722013764 trimer interface [polypeptide binding]; other site 137722013765 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722013766 MULE transposase domain; Region: MULE; pfam10551 137722013767 Transposase; Region: DEDD_Tnp_IS110; pfam01548 137722013768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 137722013769 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 137722013770 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 137722013771 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 137722013772 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 137722013773 active site 137722013774 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 137722013775 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722013776 active site 137722013777 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 137722013778 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 137722013779 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 137722013780 catalytic site [active] 137722013781 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 137722013782 Ligand Binding Site [chemical binding]; other site 137722013783 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 137722013784 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722013785 catalytic loop [active] 137722013786 iron binding site [ion binding]; other site 137722013787 Electron transfer flavoprotein domain; Region: ETF; pfam01012 137722013788 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 137722013789 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 137722013790 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 137722013791 Ligand binding site [chemical binding]; other site 137722013792 Electron transfer flavoprotein domain; Region: ETF; pfam01012 137722013793 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 137722013794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 137722013795 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 137722013796 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 137722013797 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722013798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722013799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722013800 dimerization interface [polypeptide binding]; other site 137722013801 classical (c) SDRs; Region: SDR_c; cd05233 137722013802 NAD(P) binding site [chemical binding]; other site 137722013803 active site 137722013804 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 137722013805 Cytochrome P450; Region: p450; cl12078 137722013806 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722013807 MULE transposase domain; Region: MULE; pfam10551 137722013808 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013809 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722013810 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722013811 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013812 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722013813 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722013814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722013815 Walker A motif; other site 137722013816 ATP binding site [chemical binding]; other site 137722013817 Walker B motif; other site 137722013818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722013819 Homeodomain-like domain; Region: HTH_23; pfam13384 137722013820 Integrase core domain; Region: rve; pfam00665 137722013821 Integrase core domain; Region: rve_3; cl15866 137722013822 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722013823 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722013824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722013825 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722013826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722013827 Transposase; Region: HTH_Tnp_1; pfam01527 137722013828 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722013829 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722013830 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722013831 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722013832 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722013833 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722013834 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722013835 Integrase core domain; Region: rve_3; pfam13683 137722013836 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 137722013837 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 137722013838 active site 137722013839 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 137722013840 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722013841 active site 137722013842 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 137722013843 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722013844 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722013845 active site 137722013846 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722013847 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722013848 active site 137722013849 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 137722013850 DUF35 OB-fold domain; Region: DUF35; pfam01796 137722013851 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 137722013852 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722013853 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 137722013854 acyl-activating enzyme (AAE) consensus motif; other site 137722013855 acyl-activating enzyme (AAE) consensus motif; other site 137722013856 putative AMP binding site [chemical binding]; other site 137722013857 putative active site [active] 137722013858 putative CoA binding site [chemical binding]; other site 137722013859 Transposase; Region: DEDD_Tnp_IS110; pfam01548 137722013860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 137722013861 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 137722013862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722013863 enoyl-CoA hydratase; Region: PLN02864 137722013864 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 137722013865 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 137722013866 dimer interaction site [polypeptide binding]; other site 137722013867 substrate-binding tunnel; other site 137722013868 active site 137722013869 catalytic site [active] 137722013870 substrate binding site [chemical binding]; other site 137722013871 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 137722013872 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 137722013873 dimer interface [polypeptide binding]; other site 137722013874 active site 137722013875 thiolase; Provisional; Region: PRK06158 137722013876 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 137722013877 active site 137722013878 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722013879 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722013880 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722013881 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 137722013882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722013883 NAD(P) binding site [chemical binding]; other site 137722013884 active site 137722013885 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 137722013886 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722013887 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722013888 active site 137722013889 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 137722013890 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722013891 active site 137722013892 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 137722013893 CoA-transferase family III; Region: CoA_transf_3; pfam02515 137722013894 Transcriptional regulator [Transcription]; Region: IclR; COG1414 137722013895 Bacterial transcriptional regulator; Region: IclR; pfam01614 137722013896 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 137722013897 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013898 substrate binding site [chemical binding]; other site 137722013899 oxyanion hole (OAH) forming residues; other site 137722013900 trimer interface [polypeptide binding]; other site 137722013901 enoyl-CoA hydratase; Provisional; Region: PRK06688 137722013902 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013903 substrate binding site [chemical binding]; other site 137722013904 oxyanion hole (OAH) forming residues; other site 137722013905 trimer interface [polypeptide binding]; other site 137722013906 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 137722013907 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 137722013908 FMN binding site [chemical binding]; other site 137722013909 substrate binding site [chemical binding]; other site 137722013910 putative catalytic residue [active] 137722013911 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 137722013912 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 137722013913 dimer interface [polypeptide binding]; other site 137722013914 active site 137722013915 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 137722013916 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 137722013917 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722013918 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722013919 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 137722013920 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013921 substrate binding site [chemical binding]; other site 137722013922 oxyanion hole (OAH) forming residues; other site 137722013923 trimer interface [polypeptide binding]; other site 137722013924 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 137722013925 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 137722013926 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 137722013927 active site 2 [active] 137722013928 active site 1 [active] 137722013929 enoyl-CoA hydratase; Provisional; Region: PRK06688 137722013930 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013931 substrate binding site [chemical binding]; other site 137722013932 oxyanion hole (OAH) forming residues; other site 137722013933 trimer interface [polypeptide binding]; other site 137722013934 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 137722013935 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013936 substrate binding site [chemical binding]; other site 137722013937 oxyanion hole (OAH) forming residues; other site 137722013938 trimer interface [polypeptide binding]; other site 137722013939 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 137722013940 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722013941 substrate binding site [chemical binding]; other site 137722013942 oxyanion hole (OAH) forming residues; other site 137722013943 trimer interface [polypeptide binding]; other site 137722013944 Integrase core domain; Region: rve_3; cl15866 137722013945 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 137722013946 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 137722013947 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722013948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722013949 Walker A motif; other site 137722013950 ATP binding site [chemical binding]; other site 137722013951 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722013952 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722013953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722013954 Integrase core domain; Region: rve; pfam00665 137722013955 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 137722013956 putative active site [active] 137722013957 putative substrate binding site [chemical binding]; other site 137722013958 ATP binding site [chemical binding]; other site 137722013959 Phosphotransferase enzyme family; Region: APH; pfam01636 137722013960 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722013961 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722013962 active site 137722013963 short chain dehydrogenase; Provisional; Region: PRK06949 137722013964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722013965 NAD(P) binding site [chemical binding]; other site 137722013966 active site 137722013967 Ferritin-like; Region: Ferritin-like; pfam12902 137722013968 Integrase core domain; Region: rve_2; pfam13333 137722013969 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722013970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722013971 The C-terminal substrate binding domain of LysR-type transcriptional regulator PnbR, which is involved in regulating the pnb genes encoding enzymes for 4-nitrobenzoate catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_PnbR; cd08469 137722013972 putative substrate binding pocket [chemical binding]; other site 137722013973 putative dimerization interface [polypeptide binding]; other site 137722013974 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 137722013975 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 137722013976 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722013977 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 137722013978 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 137722013979 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 137722013980 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 137722013981 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 137722013982 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 137722013983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722013984 DNA-binding site [nucleotide binding]; DNA binding site 137722013985 UTRA domain; Region: UTRA; pfam07702 137722013986 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 137722013987 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 137722013988 substrate binding site [chemical binding]; other site 137722013989 dimer interface [polypeptide binding]; other site 137722013990 ATP binding site [chemical binding]; other site 137722013991 threonine synthase; Validated; Region: PRK08197 137722013992 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 137722013993 homodimer interface [polypeptide binding]; other site 137722013994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722013995 catalytic residue [active] 137722013996 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722013997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722013998 putative PBP binding loops; other site 137722013999 ABC-ATPase subunit interface; other site 137722014000 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722014001 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722014002 Walker A/P-loop; other site 137722014003 ATP binding site [chemical binding]; other site 137722014004 Q-loop/lid; other site 137722014005 ABC transporter signature motif; other site 137722014006 Walker B; other site 137722014007 D-loop; other site 137722014008 H-loop/switch region; other site 137722014009 NMT1-like family; Region: NMT1_2; pfam13379 137722014010 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 137722014011 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722014012 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 137722014013 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 137722014014 hypothetical protein; Provisional; Region: PRK06208 137722014015 intersubunit interface [polypeptide binding]; other site 137722014016 active site 137722014017 Zn2+ binding site [ion binding]; other site 137722014018 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180 137722014019 putative ligand binding site [chemical binding]; other site 137722014020 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 137722014021 putative NAD binding site [chemical binding]; other site 137722014022 catalytic site [active] 137722014023 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 137722014024 active site 137722014025 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 137722014026 dimer interface [polypeptide binding]; other site 137722014027 non-prolyl cis peptide bond; other site 137722014028 insertion regions; other site 137722014029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722014030 substrate binding pocket [chemical binding]; other site 137722014031 membrane-bound complex binding site; other site 137722014032 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722014033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722014034 Walker A/P-loop; other site 137722014035 ATP binding site [chemical binding]; other site 137722014036 Q-loop/lid; other site 137722014037 ABC transporter signature motif; other site 137722014038 Walker B; other site 137722014039 D-loop; other site 137722014040 H-loop/switch region; other site 137722014041 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722014042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014043 dimer interface [polypeptide binding]; other site 137722014044 conserved gate region; other site 137722014045 putative PBP binding loops; other site 137722014046 ABC-ATPase subunit interface; other site 137722014047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722014048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722014049 dimerization interface [polypeptide binding]; other site 137722014050 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 137722014051 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722014052 membrane-bound complex binding site; other site 137722014053 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 137722014054 active site residue [active] 137722014055 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 137722014056 active site residue [active] 137722014057 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 137722014058 active site residue [active] 137722014059 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 137722014060 active site residue [active] 137722014061 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 137722014062 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722014063 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722014064 Walker A/P-loop; other site 137722014065 ATP binding site [chemical binding]; other site 137722014066 Q-loop/lid; other site 137722014067 ABC transporter signature motif; other site 137722014068 Walker B; other site 137722014069 D-loop; other site 137722014070 H-loop/switch region; other site 137722014071 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722014072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014073 dimer interface [polypeptide binding]; other site 137722014074 conserved gate region; other site 137722014075 putative PBP binding loops; other site 137722014076 ABC-ATPase subunit interface; other site 137722014077 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 137722014078 putative FMN binding site [chemical binding]; other site 137722014079 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 137722014080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722014081 substrate binding pocket [chemical binding]; other site 137722014082 membrane-bound complex binding site; other site 137722014083 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 137722014084 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722014085 Walker A/P-loop; other site 137722014086 ATP binding site [chemical binding]; other site 137722014087 Q-loop/lid; other site 137722014088 ABC transporter signature motif; other site 137722014089 Walker B; other site 137722014090 D-loop; other site 137722014091 H-loop/switch region; other site 137722014092 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722014093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014094 ABC-ATPase subunit interface; other site 137722014095 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 137722014096 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 137722014097 active site 137722014098 iron coordination sites [ion binding]; other site 137722014099 substrate binding pocket [chemical binding]; other site 137722014100 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722014101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722014102 active site 137722014103 phosphorylation site [posttranslational modification] 137722014104 intermolecular recognition site; other site 137722014105 dimerization interface [polypeptide binding]; other site 137722014106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722014107 DNA binding site [nucleotide binding] 137722014108 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 137722014109 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 137722014110 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 137722014111 Ligand Binding Site [chemical binding]; other site 137722014112 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 137722014113 GAF domain; Region: GAF_3; pfam13492 137722014114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722014115 phosphorylation site [posttranslational modification] 137722014116 dimer interface [polypeptide binding]; other site 137722014117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722014118 ATP binding site [chemical binding]; other site 137722014119 Mg2+ binding site [ion binding]; other site 137722014120 G-X-G motif; other site 137722014121 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 137722014122 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 137722014123 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 137722014124 Soluble P-type ATPase [General function prediction only]; Region: COG4087 137722014125 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 137722014126 tricarballylate dehydrogenase; Validated; Region: PRK08274 137722014127 CitB domain protein; Region: CitB; TIGR02484 137722014128 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 137722014129 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 137722014130 dimer interface [polypeptide binding]; other site 137722014131 NADP binding site [chemical binding]; other site 137722014132 catalytic residues [active] 137722014133 Transcriptional regulators [Transcription]; Region: FadR; COG2186 137722014134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722014135 DNA-binding site [nucleotide binding]; DNA binding site 137722014136 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 137722014137 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 137722014138 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 137722014139 putative active site [active] 137722014140 catalytic residue [active] 137722014141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722014142 D-galactonate transporter; Region: 2A0114; TIGR00893 137722014143 putative substrate translocation pore; other site 137722014144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722014145 galactarate dehydratase; Region: galactar-dH20; TIGR03248 137722014146 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 137722014147 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 137722014148 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 137722014149 HAMP domain; Region: HAMP; pfam00672 137722014150 dimerization interface [polypeptide binding]; other site 137722014151 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722014152 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722014153 dimer interface [polypeptide binding]; other site 137722014154 putative CheW interface [polypeptide binding]; other site 137722014155 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 137722014156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722014157 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 137722014158 putative dimerization interface [polypeptide binding]; other site 137722014159 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 137722014160 Citrate transporter; Region: CitMHS; pfam03600 137722014161 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 137722014162 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 137722014163 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722014164 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722014165 putative DNA binding site [nucleotide binding]; other site 137722014166 putative Zn2+ binding site [ion binding]; other site 137722014167 AsnC family; Region: AsnC_trans_reg; pfam01037 137722014168 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 137722014169 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 137722014170 AAA domain; Region: AAA_30; pfam13604 137722014171 Family description; Region: UvrD_C_2; pfam13538 137722014172 Predicted membrane protein [Function unknown]; Region: COG2855 137722014173 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 137722014174 30S subunit binding site; other site 137722014175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722014176 non-specific DNA binding site [nucleotide binding]; other site 137722014177 salt bridge; other site 137722014178 sequence-specific DNA binding site [nucleotide binding]; other site 137722014179 Cupin domain; Region: Cupin_2; pfam07883 137722014180 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 137722014181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722014182 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 137722014183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722014184 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 137722014185 substrate binding site [chemical binding]; other site 137722014186 activation loop (A-loop); other site 137722014187 Predicted ATPase [General function prediction only]; Region: COG3899 137722014188 AAA ATPase domain; Region: AAA_16; pfam13191 137722014189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 137722014190 Histidine kinase; Region: HisKA_2; pfam07568 137722014191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722014192 ATP binding site [chemical binding]; other site 137722014193 Mg2+ binding site [ion binding]; other site 137722014194 G-X-G motif; other site 137722014195 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722014196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722014197 active site 137722014198 phosphorylation site [posttranslational modification] 137722014199 intermolecular recognition site; other site 137722014200 dimerization interface [polypeptide binding]; other site 137722014201 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722014202 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722014203 putative active site [active] 137722014204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722014205 dimer interface [polypeptide binding]; other site 137722014206 phosphorylation site [posttranslational modification] 137722014207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722014208 ATP binding site [chemical binding]; other site 137722014209 Mg2+ binding site [ion binding]; other site 137722014210 G-X-G motif; other site 137722014211 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 137722014212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722014213 active site 137722014214 phosphorylation site [posttranslational modification] 137722014215 intermolecular recognition site; other site 137722014216 dimerization interface [polypeptide binding]; other site 137722014217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722014218 DNA binding residues [nucleotide binding] 137722014219 dimerization interface [polypeptide binding]; other site 137722014220 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722014221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722014222 dimer interface [polypeptide binding]; other site 137722014223 putative CheW interface [polypeptide binding]; other site 137722014224 Predicted membrane protein [Function unknown]; Region: COG2510 137722014225 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 137722014226 active site 137722014227 homodimer interface [polypeptide binding]; other site 137722014228 homotetramer interface [polypeptide binding]; other site 137722014229 Caspase domain; Region: Peptidase_C14; pfam00656 137722014230 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 137722014231 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 137722014232 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 137722014233 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 137722014234 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 137722014235 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 137722014236 hinge regions; other site 137722014237 ADP binding site [chemical binding]; other site 137722014238 catalytic site [active] 137722014239 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 137722014240 EamA-like transporter family; Region: EamA; pfam00892 137722014241 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 137722014242 propionate/acetate kinase; Provisional; Region: PRK12379 137722014243 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 137722014244 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 137722014245 dimer interaction site [polypeptide binding]; other site 137722014246 substrate-binding tunnel; other site 137722014247 active site 137722014248 catalytic site [active] 137722014249 substrate binding site [chemical binding]; other site 137722014250 phosphate acetyltransferase; Provisional; Region: PRK11890 137722014251 enolase; Provisional; Region: eno; PRK00077 137722014252 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 137722014253 dimer interface [polypeptide binding]; other site 137722014254 metal binding site [ion binding]; metal-binding site 137722014255 substrate binding pocket [chemical binding]; other site 137722014256 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 137722014257 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722014258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722014259 DNA-binding site [nucleotide binding]; DNA binding site 137722014260 FCD domain; Region: FCD; pfam07729 137722014261 Malonate transporter MadL subunit; Region: MadL; cl04273 137722014262 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 137722014263 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 137722014264 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 137722014265 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 137722014266 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 137722014267 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 137722014268 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 137722014269 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 137722014270 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 137722014271 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 137722014272 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 137722014273 EamA-like transporter family; Region: EamA; pfam00892 137722014274 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 137722014275 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 137722014276 active site 137722014277 Zn binding site [ion binding]; other site 137722014278 allantoate amidohydrolase; Reviewed; Region: PRK12893 137722014279 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 137722014280 active site 137722014281 metal binding site [ion binding]; metal-binding site 137722014282 dimer interface [polypeptide binding]; other site 137722014283 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 137722014284 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 137722014285 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 137722014286 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 137722014287 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722014288 Walker A/P-loop; other site 137722014289 ATP binding site [chemical binding]; other site 137722014290 Q-loop/lid; other site 137722014291 ABC transporter signature motif; other site 137722014292 Walker B; other site 137722014293 D-loop; other site 137722014294 H-loop/switch region; other site 137722014295 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 137722014296 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722014297 Walker A/P-loop; other site 137722014298 ATP binding site [chemical binding]; other site 137722014299 Q-loop/lid; other site 137722014300 ABC transporter signature motif; other site 137722014301 Walker B; other site 137722014302 D-loop; other site 137722014303 H-loop/switch region; other site 137722014304 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722014305 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 137722014306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014307 dimer interface [polypeptide binding]; other site 137722014308 conserved gate region; other site 137722014309 putative PBP binding loops; other site 137722014310 ABC-ATPase subunit interface; other site 137722014311 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 137722014312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014313 dimer interface [polypeptide binding]; other site 137722014314 conserved gate region; other site 137722014315 putative PBP binding loops; other site 137722014316 ABC-ATPase subunit interface; other site 137722014317 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 137722014318 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 137722014319 aldolase II superfamily protein; Provisional; Region: PRK07044 137722014320 intersubunit interface [polypeptide binding]; other site 137722014321 active site 137722014322 Zn2+ binding site [ion binding]; other site 137722014323 acetylornithine deacetylase; Provisional; Region: PRK06837 137722014324 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 137722014325 metal binding site [ion binding]; metal-binding site 137722014326 dimer interface [polypeptide binding]; other site 137722014327 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722014328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722014329 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722014330 dimerization interface [polypeptide binding]; other site 137722014331 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 137722014332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722014333 NAD(P) binding site [chemical binding]; other site 137722014334 active site 137722014335 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 137722014336 classical (c) SDRs; Region: SDR_c; cd05233 137722014337 NAD(P) binding site [chemical binding]; other site 137722014338 active site 137722014339 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 137722014340 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 137722014341 BNR repeat-like domain; Region: BNR_2; pfam13088 137722014342 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 137722014343 Na binding site [ion binding]; other site 137722014344 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 137722014345 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 137722014346 inhibitor site; inhibition site 137722014347 active site 137722014348 dimer interface [polypeptide binding]; other site 137722014349 catalytic residue [active] 137722014350 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 137722014351 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 137722014352 putative active site [active] 137722014353 metal binding site [ion binding]; metal-binding site 137722014354 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 137722014355 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 137722014356 Protein of unknown function, DUF1537; Region: DUF1537; pfam07005 137722014357 Transcriptional regulators [Transcription]; Region: FadR; COG2186 137722014358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722014359 DNA-binding site [nucleotide binding]; DNA binding site 137722014360 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 137722014361 threonine dehydratase; Reviewed; Region: PRK09224 137722014362 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 137722014363 tetramer interface [polypeptide binding]; other site 137722014364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722014365 catalytic residue [active] 137722014366 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 137722014367 putative Ile/Val binding site [chemical binding]; other site 137722014368 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 137722014369 putative Ile/Val binding site [chemical binding]; other site 137722014370 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722014371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722014372 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 137722014373 putative effector binding pocket; other site 137722014374 dimerization interface [polypeptide binding]; other site 137722014375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722014376 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 137722014377 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 137722014378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722014379 DNA-binding site [nucleotide binding]; DNA binding site 137722014380 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 137722014381 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 137722014382 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 137722014383 active site 137722014384 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 137722014385 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 137722014386 Predicted helicase [General function prediction only]; Region: COG4889 137722014387 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 137722014388 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 137722014389 substrate binding site [chemical binding]; other site 137722014390 dimer interface [polypeptide binding]; other site 137722014391 ATP binding site [chemical binding]; other site 137722014392 Transcriptional regulators [Transcription]; Region: PurR; COG1609 137722014393 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 137722014394 DNA binding site [nucleotide binding] 137722014395 domain linker motif; other site 137722014396 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 137722014397 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 137722014398 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 137722014399 ligand binding site [chemical binding]; other site 137722014400 dimerization interface [polypeptide binding]; other site 137722014401 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722014402 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 137722014403 TM-ABC transporter signature motif; other site 137722014404 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 137722014405 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 137722014406 Walker A/P-loop; other site 137722014407 ATP binding site [chemical binding]; other site 137722014408 Q-loop/lid; other site 137722014409 ABC transporter signature motif; other site 137722014410 Walker B; other site 137722014411 D-loop; other site 137722014412 H-loop/switch region; other site 137722014413 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 137722014414 D-ribose pyranase; Provisional; Region: PRK11797 137722014415 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 137722014416 agmatinase; Region: agmatinase; TIGR01230 137722014417 oligomer interface [polypeptide binding]; other site 137722014418 putative active site [active] 137722014419 Mn binding site [ion binding]; other site 137722014420 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 137722014421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 137722014422 hydroxyglutarate oxidase; Provisional; Region: PRK11728 137722014423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722014424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722014425 amidase; Provisional; Region: PRK07487 137722014426 Amidase; Region: Amidase; cl11426 137722014427 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 137722014428 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 137722014429 NAD binding site [chemical binding]; other site 137722014430 catalytic residues [active] 137722014431 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 137722014432 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 137722014433 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 137722014434 FMN-binding pocket [chemical binding]; other site 137722014435 flavin binding motif; other site 137722014436 phosphate binding motif [ion binding]; other site 137722014437 beta-alpha-beta structure motif; other site 137722014438 NAD binding pocket [chemical binding]; other site 137722014439 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722014440 catalytic loop [active] 137722014441 iron binding site [ion binding]; other site 137722014442 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722014443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722014444 DNA-binding site [nucleotide binding]; DNA binding site 137722014445 FCD domain; Region: FCD; pfam07729 137722014446 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 137722014447 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 137722014448 iron-sulfur cluster [ion binding]; other site 137722014449 [2Fe-2S] cluster binding site [ion binding]; other site 137722014450 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 137722014451 alpha subunit interface [polypeptide binding]; other site 137722014452 active site 137722014453 substrate binding site [chemical binding]; other site 137722014454 Fe binding site [ion binding]; other site 137722014455 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722014456 MarR family; Region: MarR_2; cl17246 137722014457 benzoate transport; Region: 2A0115; TIGR00895 137722014458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722014459 putative substrate translocation pore; other site 137722014460 acyl-CoA synthetase; Validated; Region: PRK09088 137722014461 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722014462 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 137722014463 acyl-activating enzyme (AAE) consensus motif; other site 137722014464 acyl-activating enzyme (AAE) consensus motif; other site 137722014465 putative AMP binding site [chemical binding]; other site 137722014466 putative active site [active] 137722014467 putative CoA binding site [chemical binding]; other site 137722014468 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 137722014469 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722014470 substrate binding site [chemical binding]; other site 137722014471 oxyanion hole (OAH) forming residues; other site 137722014472 trimer interface [polypeptide binding]; other site 137722014473 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 137722014474 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 137722014475 NAD(P) binding site [chemical binding]; other site 137722014476 catalytic residues [active] 137722014477 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 137722014478 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 137722014479 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 137722014480 aminotransferase; Provisional; Region: PRK06105 137722014481 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 137722014482 inhibitor-cofactor binding pocket; inhibition site 137722014483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722014484 catalytic residue [active] 137722014485 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 137722014486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722014487 Walker A/P-loop; other site 137722014488 ATP binding site [chemical binding]; other site 137722014489 Q-loop/lid; other site 137722014490 ABC transporter signature motif; other site 137722014491 Walker B; other site 137722014492 D-loop; other site 137722014493 H-loop/switch region; other site 137722014494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014495 dimer interface [polypeptide binding]; other site 137722014496 conserved gate region; other site 137722014497 putative PBP binding loops; other site 137722014498 ABC-ATPase subunit interface; other site 137722014499 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 137722014500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014501 dimer interface [polypeptide binding]; other site 137722014502 conserved gate region; other site 137722014503 putative PBP binding loops; other site 137722014504 ABC-ATPase subunit interface; other site 137722014505 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 137722014506 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722014507 substrate binding pocket [chemical binding]; other site 137722014508 membrane-bound complex binding site; other site 137722014509 hinge residues; other site 137722014510 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 137722014511 agmatinase; Region: agmatinase; TIGR01230 137722014512 oligomer interface [polypeptide binding]; other site 137722014513 putative active site [active] 137722014514 Mn binding site [ion binding]; other site 137722014515 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722014516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722014517 DNA-binding site [nucleotide binding]; DNA binding site 137722014518 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 137722014519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722014520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722014521 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722014522 dimerization interface [polypeptide binding]; other site 137722014523 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 137722014524 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 137722014525 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722014526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722014527 Walker A/P-loop; other site 137722014528 ATP binding site [chemical binding]; other site 137722014529 Q-loop/lid; other site 137722014530 ABC transporter signature motif; other site 137722014531 Walker B; other site 137722014532 D-loop; other site 137722014533 H-loop/switch region; other site 137722014534 TOBE domain; Region: TOBE_2; pfam08402 137722014535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014536 putative PBP binding loops; other site 137722014537 ABC-ATPase subunit interface; other site 137722014538 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722014539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014540 dimer interface [polypeptide binding]; other site 137722014541 conserved gate region; other site 137722014542 putative PBP binding loops; other site 137722014543 ABC-ATPase subunit interface; other site 137722014544 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 137722014545 agmatinase; Region: agmatinase; TIGR01230 137722014546 oligomer interface [polypeptide binding]; other site 137722014547 putative active site [active] 137722014548 Mn binding site [ion binding]; other site 137722014549 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 137722014550 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722014551 Walker A/P-loop; other site 137722014552 ATP binding site [chemical binding]; other site 137722014553 Q-loop/lid; other site 137722014554 ABC transporter signature motif; other site 137722014555 Walker B; other site 137722014556 D-loop; other site 137722014557 H-loop/switch region; other site 137722014558 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722014559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014560 dimer interface [polypeptide binding]; other site 137722014561 conserved gate region; other site 137722014562 putative PBP binding loops; other site 137722014563 ABC-ATPase subunit interface; other site 137722014564 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 137722014565 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 137722014566 allophanate hydrolase; Provisional; Region: PRK08186 137722014567 Amidase; Region: Amidase; cl11426 137722014568 urea carboxylase; Region: urea_carbox; TIGR02712 137722014569 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 137722014570 ATP-grasp domain; Region: ATP-grasp_4; cl17255 137722014571 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 137722014572 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 137722014573 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 137722014574 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 137722014575 carboxyltransferase (CT) interaction site; other site 137722014576 biotinylation site [posttranslational modification]; other site 137722014577 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 137722014578 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 137722014579 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 137722014580 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 137722014581 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 137722014582 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 137722014583 inhibitor-cofactor binding pocket; inhibition site 137722014584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722014585 catalytic residue [active] 137722014586 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 137722014587 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 137722014588 active site 137722014589 ATP binding site [chemical binding]; other site 137722014590 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722014591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722014592 DNA-binding site [nucleotide binding]; DNA binding site 137722014593 FCD domain; Region: FCD; pfam07729 137722014594 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 137722014595 Homeodomain-like domain; Region: HTH_23; pfam13384 137722014596 Winged helix-turn helix; Region: HTH_29; pfam13551 137722014597 Homeodomain-like domain; Region: HTH_32; pfam13565 137722014598 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722014599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 137722014600 HTH-like domain; Region: HTH_21; pfam13276 137722014601 Integrase core domain; Region: rve; pfam00665 137722014602 Integrase core domain; Region: rve_3; pfam13683 137722014603 Transposase; Region: HTH_Tnp_1; cl17663 137722014604 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722014605 Transposase; Region: DEDD_Tnp_IS110; pfam01548 137722014606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 137722014607 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 137722014608 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722014609 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722014610 Cytochrome c2 [Energy production and conversion]; Region: COG3474 137722014611 Transposase; Region: DEDD_Tnp_IS110; pfam01548 137722014612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 137722014613 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 137722014614 active site 2 [active] 137722014615 active site 1 [active] 137722014616 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 137722014617 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 137722014618 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 137722014619 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 137722014620 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 137722014621 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 137722014622 serine transporter; Region: stp; TIGR00814 137722014623 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 137722014624 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 137722014625 Histidine kinase; Region: His_kinase; pfam06580 137722014626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722014627 ATP binding site [chemical binding]; other site 137722014628 Mg2+ binding site [ion binding]; other site 137722014629 G-X-G motif; other site 137722014630 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 137722014631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722014632 active site 137722014633 phosphorylation site [posttranslational modification] 137722014634 intermolecular recognition site; other site 137722014635 dimerization interface [polypeptide binding]; other site 137722014636 LytTr DNA-binding domain; Region: LytTR; pfam04397 137722014637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722014638 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722014639 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722014640 dimerization interface [polypeptide binding]; other site 137722014641 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 137722014642 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 137722014643 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 137722014644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014645 dimer interface [polypeptide binding]; other site 137722014646 conserved gate region; other site 137722014647 putative PBP binding loops; other site 137722014648 ABC-ATPase subunit interface; other site 137722014649 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 137722014650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014651 dimer interface [polypeptide binding]; other site 137722014652 conserved gate region; other site 137722014653 putative PBP binding loops; other site 137722014654 ABC-ATPase subunit interface; other site 137722014655 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 137722014656 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722014657 Walker A/P-loop; other site 137722014658 ATP binding site [chemical binding]; other site 137722014659 Q-loop/lid; other site 137722014660 ABC transporter signature motif; other site 137722014661 Walker B; other site 137722014662 D-loop; other site 137722014663 H-loop/switch region; other site 137722014664 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722014665 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 137722014666 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722014667 Walker A/P-loop; other site 137722014668 ATP binding site [chemical binding]; other site 137722014669 Q-loop/lid; other site 137722014670 ABC transporter signature motif; other site 137722014671 Walker B; other site 137722014672 D-loop; other site 137722014673 H-loop/switch region; other site 137722014674 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722014675 hypothetical protein; Provisional; Region: PRK07079 137722014676 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 137722014677 metal binding site [ion binding]; metal-binding site 137722014678 putative dimer interface [polypeptide binding]; other site 137722014679 hypothetical protein; Provisional; Region: PRK07338 137722014680 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 137722014681 metal binding site [ion binding]; metal-binding site 137722014682 dimer interface [polypeptide binding]; other site 137722014683 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 137722014684 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 137722014685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722014686 catalytic residue [active] 137722014687 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722014688 putative DNA binding site [nucleotide binding]; other site 137722014689 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722014690 putative Zn2+ binding site [ion binding]; other site 137722014691 AsnC family; Region: AsnC_trans_reg; pfam01037 137722014692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722014693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722014694 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 137722014695 homotrimer interaction site [polypeptide binding]; other site 137722014696 putative active site [active] 137722014697 Hemerythrin-like domain; Region: Hr-like; cd12108 137722014698 Fe binding site [ion binding]; other site 137722014699 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 137722014700 Amidase; Region: Amidase; cl11426 137722014701 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 137722014702 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 137722014703 putative ligand binding site [chemical binding]; other site 137722014704 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722014705 TM-ABC transporter signature motif; other site 137722014706 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 137722014707 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722014708 TM-ABC transporter signature motif; other site 137722014709 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722014710 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722014711 Walker A/P-loop; other site 137722014712 ATP binding site [chemical binding]; other site 137722014713 Q-loop/lid; other site 137722014714 ABC transporter signature motif; other site 137722014715 Walker B; other site 137722014716 D-loop; other site 137722014717 H-loop/switch region; other site 137722014718 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722014719 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722014720 Walker A/P-loop; other site 137722014721 ATP binding site [chemical binding]; other site 137722014722 Q-loop/lid; other site 137722014723 ABC transporter signature motif; other site 137722014724 Walker B; other site 137722014725 D-loop; other site 137722014726 H-loop/switch region; other site 137722014727 Transcriptional regulators [Transcription]; Region: MarR; COG1846 137722014728 MarR family; Region: MarR_2; cl17246 137722014729 PAS domain S-box; Region: sensory_box; TIGR00229 137722014730 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722014731 putative active site [active] 137722014732 heme pocket [chemical binding]; other site 137722014733 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722014734 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722014735 metal binding site [ion binding]; metal-binding site 137722014736 active site 137722014737 I-site; other site 137722014738 HupF/HypC family; Region: HupF_HypC; pfam01455 137722014739 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 137722014740 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 137722014741 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 137722014742 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 137722014743 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 137722014744 nickel binding site [ion binding]; other site 137722014745 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 137722014746 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 137722014747 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 137722014748 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 137722014749 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 137722014750 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 137722014751 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 137722014752 hydrogenase 4 subunit F; Validated; Region: PRK06458 137722014753 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 137722014754 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 137722014755 hydrogenase 4 subunit D; Validated; Region: PRK06525 137722014756 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 137722014757 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 137722014758 NADH dehydrogenase; Region: NADHdh; cl00469 137722014759 hydrogenase 4 subunit B; Validated; Region: PRK06521 137722014760 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 137722014761 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 137722014762 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 137722014763 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 137722014764 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 137722014765 [4Fe-4S] binding site [ion binding]; other site 137722014766 molybdopterin cofactor binding site; other site 137722014767 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 137722014768 molybdopterin cofactor binding site; other site 137722014769 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 137722014770 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722014771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722014772 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722014773 dimerization interface [polypeptide binding]; other site 137722014774 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 137722014775 HD domain; Region: HD_4; pfam13328 137722014776 manganese transport protein MntH; Reviewed; Region: PRK00701 137722014777 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 137722014778 manganese transport regulator MntR; Provisional; Region: PRK11050 137722014779 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 137722014780 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 137722014781 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722014782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722014783 active site 137722014784 phosphorylation site [posttranslational modification] 137722014785 intermolecular recognition site; other site 137722014786 dimerization interface [polypeptide binding]; other site 137722014787 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722014788 DNA binding residues [nucleotide binding] 137722014789 dimerization interface [polypeptide binding]; other site 137722014790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 137722014791 Histidine kinase; Region: HisKA_3; pfam07730 137722014792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722014793 ATP binding site [chemical binding]; other site 137722014794 Mg2+ binding site [ion binding]; other site 137722014795 G-X-G motif; other site 137722014796 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 137722014797 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 137722014798 dimer interface [polypeptide binding]; other site 137722014799 Trp docking motif [polypeptide binding]; other site 137722014800 active site 137722014801 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722014802 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722014803 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722014804 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 137722014805 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722014806 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 137722014807 ferrous iron transporter FeoB; Region: feoB; TIGR00437 137722014808 G1 box; other site 137722014809 GTP/Mg2+ binding site [chemical binding]; other site 137722014810 Switch I region; other site 137722014811 G2 box; other site 137722014812 G3 box; other site 137722014813 Switch II region; other site 137722014814 G4 box; other site 137722014815 G5 box; other site 137722014816 Nucleoside recognition; Region: Gate; pfam07670 137722014817 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 137722014818 Nucleoside recognition; Region: Gate; pfam07670 137722014819 FeoA domain; Region: FeoA; pfam04023 137722014820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722014821 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722014822 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 137722014823 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 137722014824 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 137722014825 catalytic core [active] 137722014826 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 137722014827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722014828 dimerization interface [polypeptide binding]; other site 137722014829 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722014830 dimer interface [polypeptide binding]; other site 137722014831 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722014832 putative CheW interface [polypeptide binding]; other site 137722014833 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 137722014834 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722014835 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 137722014836 DNA binding residues [nucleotide binding] 137722014837 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 137722014838 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 137722014839 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 137722014840 4Fe-4S binding domain; Region: Fer4; cl02805 137722014841 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 137722014842 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 137722014843 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 137722014844 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 137722014845 MoaE interaction surface [polypeptide binding]; other site 137722014846 MoeB interaction surface [polypeptide binding]; other site 137722014847 thiocarboxylated glycine; other site 137722014848 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 137722014849 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 137722014850 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 137722014851 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 137722014852 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 137722014853 NADH dehydrogenase; Region: NADHdh; cl00469 137722014854 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 137722014855 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 137722014856 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 137722014857 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 137722014858 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 137722014859 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 137722014860 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 137722014861 putative substrate binding site [chemical binding]; other site 137722014862 putative ATP binding site [chemical binding]; other site 137722014863 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 137722014864 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 137722014865 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 137722014866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722014867 sorbitol dehydrogenase; Provisional; Region: PRK07067 137722014868 NAD(P) binding site [chemical binding]; other site 137722014869 active site 137722014870 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 137722014871 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 137722014872 Walker A/P-loop; other site 137722014873 ATP binding site [chemical binding]; other site 137722014874 Q-loop/lid; other site 137722014875 ABC transporter signature motif; other site 137722014876 Walker B; other site 137722014877 D-loop; other site 137722014878 H-loop/switch region; other site 137722014879 TOBE domain; Region: TOBE_2; pfam08402 137722014880 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 137722014881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014882 dimer interface [polypeptide binding]; other site 137722014883 conserved gate region; other site 137722014884 putative PBP binding loops; other site 137722014885 ABC-ATPase subunit interface; other site 137722014886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722014887 dimer interface [polypeptide binding]; other site 137722014888 conserved gate region; other site 137722014889 putative PBP binding loops; other site 137722014890 ABC-ATPase subunit interface; other site 137722014891 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 137722014892 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 137722014893 MarR family; Region: MarR_2; pfam12802 137722014894 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 137722014895 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 137722014896 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 137722014897 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722014898 DNA-binding site [nucleotide binding]; DNA binding site 137722014899 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722014900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722014901 homodimer interface [polypeptide binding]; other site 137722014902 catalytic residue [active] 137722014903 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 137722014904 4Fe-4S binding domain; Region: Fer4_5; pfam12801 137722014905 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 137722014906 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 137722014907 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722014908 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722014909 putative DNA binding site [nucleotide binding]; other site 137722014910 putative Zn2+ binding site [ion binding]; other site 137722014911 AsnC family; Region: AsnC_trans_reg; pfam01037 137722014912 Arginase family; Region: Arginase; cd09989 137722014913 agmatinase; Region: agmatinase; TIGR01230 137722014914 active site 137722014915 Mn binding site [ion binding]; other site 137722014916 oligomer interface [polypeptide binding]; other site 137722014917 ornithine cyclodeaminase; Validated; Region: PRK07589 137722014918 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 137722014919 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 137722014920 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 137722014921 Predicted membrane protein [Function unknown]; Region: COG2259 137722014922 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 137722014923 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 137722014924 active site 137722014925 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 137722014926 Isochorismatase family; Region: Isochorismatase; pfam00857 137722014927 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 137722014928 catalytic triad [active] 137722014929 dimer interface [polypeptide binding]; other site 137722014930 conserved cis-peptide bond; other site 137722014931 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 137722014932 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 137722014933 TAP-like protein; Region: Abhydrolase_4; pfam08386 137722014934 VacJ like lipoprotein; Region: VacJ; cl01073 137722014935 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 137722014936 HPr interaction site; other site 137722014937 glycerol kinase (GK) interaction site [polypeptide binding]; other site 137722014938 active site 137722014939 phosphorylation site [posttranslational modification] 137722014940 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 137722014941 dimerization domain swap beta strand [polypeptide binding]; other site 137722014942 regulatory protein interface [polypeptide binding]; other site 137722014943 active site 137722014944 regulatory phosphorylation site [posttranslational modification]; other site 137722014945 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 137722014946 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 137722014947 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 137722014948 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 137722014949 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 137722014950 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 137722014951 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 137722014952 active site turn [active] 137722014953 phosphorylation site [posttranslational modification] 137722014954 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 137722014955 active site turn [active] 137722014956 phosphorylation site [posttranslational modification] 137722014957 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 137722014958 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 137722014959 dimer interface [polypeptide binding]; other site 137722014960 active site 137722014961 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 137722014962 dimer interface [polypeptide binding]; other site 137722014963 active site 137722014964 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 137722014965 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 137722014966 active site 137722014967 dimer interface [polypeptide binding]; other site 137722014968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722014969 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 137722014970 active site 137722014971 motif I; other site 137722014972 motif II; other site 137722014973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722014974 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 137722014975 DNA-binding site [nucleotide binding]; DNA binding site 137722014976 UTRA domain; Region: UTRA; pfam07702 137722014977 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 137722014978 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 137722014979 putative active site [active] 137722014980 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 137722014981 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 137722014982 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 137722014983 active site turn [active] 137722014984 phosphorylation site [posttranslational modification] 137722014985 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722014986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722014987 DNA-binding site [nucleotide binding]; DNA binding site 137722014988 FCD domain; Region: FCD; pfam07729 137722014989 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722014990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722014991 Walker A/P-loop; other site 137722014992 ATP binding site [chemical binding]; other site 137722014993 Q-loop/lid; other site 137722014994 ABC transporter signature motif; other site 137722014995 Walker B; other site 137722014996 D-loop; other site 137722014997 H-loop/switch region; other site 137722014998 TOBE domain; Region: TOBE_2; pfam08402 137722014999 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 137722015000 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 137722015001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722015002 dimer interface [polypeptide binding]; other site 137722015003 conserved gate region; other site 137722015004 putative PBP binding loops; other site 137722015005 ABC-ATPase subunit interface; other site 137722015006 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722015007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 137722015008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722015009 dimer interface [polypeptide binding]; other site 137722015010 ABC-ATPase subunit interface; other site 137722015011 putative PBP binding loops; other site 137722015012 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 137722015013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 137722015014 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 137722015015 amidase; Provisional; Region: PRK07056 137722015016 Amidase; Region: Amidase; cl11426 137722015017 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 137722015018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722015019 active site 137722015020 phosphorylation site [posttranslational modification] 137722015021 intermolecular recognition site; other site 137722015022 dimerization interface [polypeptide binding]; other site 137722015023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722015024 Walker A motif; other site 137722015025 ATP binding site [chemical binding]; other site 137722015026 Walker B motif; other site 137722015027 arginine finger; other site 137722015028 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722015029 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 137722015030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722015031 dimer interface [polypeptide binding]; other site 137722015032 phosphorylation site [posttranslational modification] 137722015033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722015034 ATP binding site [chemical binding]; other site 137722015035 G-X-G motif; other site 137722015036 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 137722015037 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 137722015038 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 137722015039 Aspartase; Region: Aspartase; cd01357 137722015040 active sites [active] 137722015041 tetramer interface [polypeptide binding]; other site 137722015042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 137722015043 MOSC domain; Region: MOSC; pfam03473 137722015044 3-alpha domain; Region: 3-alpha; pfam03475 137722015045 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722015046 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 137722015047 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015048 dimerization interface [polypeptide binding]; other site 137722015049 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722015050 dimer interface [polypeptide binding]; other site 137722015051 putative CheW interface [polypeptide binding]; other site 137722015052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722015053 Coenzyme A binding pocket [chemical binding]; other site 137722015054 Cache domain; Region: Cache_1; pfam02743 137722015055 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722015056 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722015057 dimer interface [polypeptide binding]; other site 137722015058 putative CheW interface [polypeptide binding]; other site 137722015059 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722015060 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722015061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722015062 Transposase; Region: HTH_Tnp_1; cl17663 137722015063 HTH-like domain; Region: HTH_21; pfam13276 137722015064 Integrase core domain; Region: rve; pfam00665 137722015065 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722015066 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722015067 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722015068 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722015069 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722015070 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722015071 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722015072 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722015073 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722015074 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722015075 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722015076 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722015077 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722015078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722015079 Integrase core domain; Region: rve; pfam00665 137722015080 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722015081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722015082 Walker A motif; other site 137722015083 ATP binding site [chemical binding]; other site 137722015084 Phage minor tail protein; Region: Phage_min_tail; cl01940 137722015085 Phage minor tail protein L; Region: Phage_tail_L; cl01908 137722015086 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 137722015087 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 137722015088 MPN+ (JAMM) motif; other site 137722015089 Zinc-binding site [ion binding]; other site 137722015090 NlpC/P60 family; Region: NLPC_P60; cl17555 137722015091 Phage-related protein, tail component [Function unknown]; Region: COG4723 137722015092 Phage-related protein, tail component [Function unknown]; Region: COG4733 137722015093 Putative phage tail protein; Region: Phage-tail_3; pfam13550 137722015094 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 137722015095 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 137722015096 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 137722015097 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 137722015098 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 137722015099 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 137722015100 catalytic residues [active] 137722015101 Transcriptional regulators [Transcription]; Region: PurR; COG1609 137722015102 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 137722015103 DNA binding site [nucleotide binding] 137722015104 domain linker motif; other site 137722015105 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 137722015106 putative dimerization interface [polypeptide binding]; other site 137722015107 putative ligand binding site [chemical binding]; other site 137722015108 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722015109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722015110 Walker A/P-loop; other site 137722015111 ATP binding site [chemical binding]; other site 137722015112 Q-loop/lid; other site 137722015113 ABC transporter signature motif; other site 137722015114 Walker B; other site 137722015115 D-loop; other site 137722015116 H-loop/switch region; other site 137722015117 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 137722015118 hypothetical protein; Provisional; Region: PRK11622 137722015119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722015120 dimer interface [polypeptide binding]; other site 137722015121 conserved gate region; other site 137722015122 putative PBP binding loops; other site 137722015123 ABC-ATPase subunit interface; other site 137722015124 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722015125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722015126 dimer interface [polypeptide binding]; other site 137722015127 conserved gate region; other site 137722015128 putative PBP binding loops; other site 137722015129 ABC-ATPase subunit interface; other site 137722015130 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 137722015131 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 137722015132 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722015133 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 137722015134 active site 137722015135 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 137722015136 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 137722015137 active site 137722015138 dimer interface [polypeptide binding]; other site 137722015139 non-prolyl cis peptide bond; other site 137722015140 insertion regions; other site 137722015141 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 137722015142 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 137722015143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722015144 Walker A motif; other site 137722015145 ATP binding site [chemical binding]; other site 137722015146 Walker B motif; other site 137722015147 arginine finger; other site 137722015148 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 137722015149 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722015150 substrate binding pocket [chemical binding]; other site 137722015151 membrane-bound complex binding site; other site 137722015152 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 137722015153 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 137722015154 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 137722015155 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 137722015156 active site 137722015157 dimer interface [polypeptide binding]; other site 137722015158 non-prolyl cis peptide bond; other site 137722015159 insertion regions; other site 137722015160 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722015161 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722015162 Walker A/P-loop; other site 137722015163 ATP binding site [chemical binding]; other site 137722015164 Q-loop/lid; other site 137722015165 ABC transporter signature motif; other site 137722015166 Walker B; other site 137722015167 D-loop; other site 137722015168 H-loop/switch region; other site 137722015169 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722015170 TM-ABC transporter signature motif; other site 137722015171 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 137722015172 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722015173 TM-ABC transporter signature motif; other site 137722015174 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 137722015175 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 137722015176 putative ligand binding site [chemical binding]; other site 137722015177 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722015178 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722015179 Walker A/P-loop; other site 137722015180 ATP binding site [chemical binding]; other site 137722015181 Q-loop/lid; other site 137722015182 ABC transporter signature motif; other site 137722015183 Walker B; other site 137722015184 D-loop; other site 137722015185 H-loop/switch region; other site 137722015186 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 137722015187 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 137722015188 Flavin binding site [chemical binding]; other site 137722015189 Helix-turn-helix domain; Region: HTH_18; pfam12833 137722015190 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 137722015191 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 137722015192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015193 dimerization interface [polypeptide binding]; other site 137722015194 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722015195 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722015196 dimer interface [polypeptide binding]; other site 137722015197 putative CheW interface [polypeptide binding]; other site 137722015198 Cupin domain; Region: Cupin_2; pfam07883 137722015199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722015200 putative substrate translocation pore; other site 137722015201 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722015202 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 137722015203 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 137722015204 dimer interface [polypeptide binding]; other site 137722015205 tetramer interface [polypeptide binding]; other site 137722015206 PYR/PP interface [polypeptide binding]; other site 137722015207 TPP binding site [chemical binding]; other site 137722015208 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 137722015209 TPP-binding site; other site 137722015210 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 137722015211 Low molecular weight phosphatase family; Region: LMWPc; cd00115 137722015212 active site 137722015213 Domain of unknown function (DUF697); Region: DUF697; cl12064 137722015214 hypothetical protein; Provisional; Region: PRK05415 137722015215 YcjX-like family, DUF463; Region: DUF463; pfam04317 137722015216 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 137722015217 TatD related DNase; Region: TatD_DNase; pfam01026 137722015218 active site 137722015219 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 137722015220 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 137722015221 active site 137722015222 metal binding site [ion binding]; metal-binding site 137722015223 UbiA prenyltransferase family; Region: UbiA; pfam01040 137722015224 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 137722015225 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 137722015226 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 137722015227 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 137722015228 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 137722015229 intersubunit interface [polypeptide binding]; other site 137722015230 active site 137722015231 catalytic residue [active] 137722015232 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 137722015233 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 137722015234 ligand binding site [chemical binding]; other site 137722015235 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 137722015236 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 137722015237 Walker A/P-loop; other site 137722015238 ATP binding site [chemical binding]; other site 137722015239 Q-loop/lid; other site 137722015240 ABC transporter signature motif; other site 137722015241 Walker B; other site 137722015242 D-loop; other site 137722015243 H-loop/switch region; other site 137722015244 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 137722015245 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722015246 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 137722015247 TM-ABC transporter signature motif; other site 137722015248 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722015249 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 137722015250 TM-ABC transporter signature motif; other site 137722015251 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 137722015252 active site 137722015253 catalytic residues [active] 137722015254 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 137722015255 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 137722015256 substrate binding site [chemical binding]; other site 137722015257 dimer interface [polypeptide binding]; other site 137722015258 ATP binding site [chemical binding]; other site 137722015259 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 137722015260 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 137722015261 N- and C-terminal domain interface [polypeptide binding]; other site 137722015262 active site 137722015263 MgATP binding site [chemical binding]; other site 137722015264 catalytic site [active] 137722015265 metal binding site [ion binding]; metal-binding site 137722015266 carbohydrate binding site [chemical binding]; other site 137722015267 putative homodimer interface [polypeptide binding]; other site 137722015268 transcriptional regulator; Provisional; Region: PRK10632 137722015269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722015270 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 137722015271 putative effector binding pocket; other site 137722015272 putative dimerization interface [polypeptide binding]; other site 137722015273 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 137722015274 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722015275 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 137722015276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722015277 Transposase; Region: HTH_Tnp_1; pfam01527 137722015278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722015279 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722015280 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722015281 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 137722015282 catalytic residues [active] 137722015283 catalytic nucleophile [active] 137722015284 Recombinase; Region: Recombinase; pfam07508 137722015285 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 137722015286 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722015287 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722015288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722015289 Walker A motif; other site 137722015290 ATP binding site [chemical binding]; other site 137722015291 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722015292 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722015293 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722015294 Integrase core domain; Region: rve; pfam00665 137722015295 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722015296 MULE transposase domain; Region: MULE; pfam10551 137722015297 MULE transposase domain; Region: MULE; pfam10551 137722015298 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722015299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015300 dimerization interface [polypeptide binding]; other site 137722015301 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722015302 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722015303 dimer interface [polypeptide binding]; other site 137722015304 putative CheW interface [polypeptide binding]; other site 137722015305 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722015306 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722015307 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722015308 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722015309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722015310 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722015311 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722015312 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722015313 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 137722015314 catalytic residues [active] 137722015315 catalytic nucleophile [active] 137722015316 Recombinase; Region: Recombinase; pfam07508 137722015317 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 137722015318 Helix-turn-helix domain; Region: HTH_17; pfam12728 137722015319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722015320 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722015321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722015322 Transposase; Region: HTH_Tnp_1; pfam01527 137722015323 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722015324 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722015325 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722015326 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 137722015327 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 137722015328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722015329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722015330 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 137722015331 Cytochrome P450; Region: p450; cl12078 137722015332 classical (c) SDRs; Region: SDR_c; cd05233 137722015333 NAD(P) binding site [chemical binding]; other site 137722015334 active site 137722015335 choline dehydrogenase; Validated; Region: PRK02106 137722015336 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 137722015337 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 137722015338 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 137722015339 NAD(P) binding site [chemical binding]; other site 137722015340 catalytic residues [active] 137722015341 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 137722015342 classical (c) SDRs; Region: SDR_c; cd05233 137722015343 NAD(P) binding site [chemical binding]; other site 137722015344 active site 137722015345 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722015346 MULE transposase domain; Region: MULE; pfam10551 137722015347 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722015348 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722015349 Homeodomain-like domain; Region: HTH_32; pfam13565 137722015350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 137722015351 Integrase core domain; Region: rve; pfam00665 137722015352 Integrase core domain; Region: rve_3; pfam13683 137722015353 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722015354 MULE transposase domain; Region: MULE; pfam10551 137722015355 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 137722015356 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 137722015357 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722015358 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722015359 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 137722015360 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722015361 ligand binding site [chemical binding]; other site 137722015362 flexible hinge region; other site 137722015363 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 137722015364 non-specific DNA interactions [nucleotide binding]; other site 137722015365 DNA binding site [nucleotide binding] 137722015366 sequence specific DNA binding site [nucleotide binding]; other site 137722015367 putative cAMP binding site [chemical binding]; other site 137722015368 Response regulator receiver domain; Region: Response_reg; pfam00072 137722015369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722015370 active site 137722015371 phosphorylation site [posttranslational modification] 137722015372 intermolecular recognition site; other site 137722015373 dimerization interface [polypeptide binding]; other site 137722015374 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 137722015375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722015376 active site 137722015377 phosphorylation site [posttranslational modification] 137722015378 intermolecular recognition site; other site 137722015379 dimerization interface [polypeptide binding]; other site 137722015380 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722015381 DNA binding residues [nucleotide binding] 137722015382 dimerization interface [polypeptide binding]; other site 137722015383 Helix-turn-helix domain; Region: HTH_36; pfam13730 137722015384 Predicted amidohydrolase [General function prediction only]; Region: COG0388 137722015385 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 137722015386 active site 137722015387 catalytic triad [active] 137722015388 dimer interface [polypeptide binding]; other site 137722015389 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 137722015390 active site 137722015391 N-formylglutamate amidohydrolase; Region: FGase; cl01522 137722015392 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 137722015393 active sites [active] 137722015394 tetramer interface [polypeptide binding]; other site 137722015395 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 137722015396 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 137722015397 active site 137722015398 imidazolonepropionase; Validated; Region: PRK09356 137722015399 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 137722015400 active site 137722015401 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 137722015402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722015403 DNA-binding site [nucleotide binding]; DNA binding site 137722015404 UTRA domain; Region: UTRA; pfam07702 137722015405 urocanate hydratase; Provisional; Region: PRK05414 137722015406 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 137722015407 beta-galactosidase; Region: BGL; TIGR03356 137722015408 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 137722015409 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722015410 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722015411 catalytic residue [active] 137722015412 Sporulation related domain; Region: SPOR; pfam05036 137722015413 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 137722015414 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 137722015415 tetramer interface [polypeptide binding]; other site 137722015416 heme binding pocket [chemical binding]; other site 137722015417 NADPH binding site [chemical binding]; other site 137722015418 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 137722015419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722015420 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 137722015421 dimerization interface [polypeptide binding]; other site 137722015422 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 137722015423 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 137722015424 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 137722015425 active site 137722015426 catalytic site [active] 137722015427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 137722015428 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 137722015429 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 137722015430 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 137722015431 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722015432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722015433 Walker A/P-loop; other site 137722015434 ATP binding site [chemical binding]; other site 137722015435 Q-loop/lid; other site 137722015436 ABC transporter signature motif; other site 137722015437 Walker B; other site 137722015438 D-loop; other site 137722015439 H-loop/switch region; other site 137722015440 TOBE domain; Region: TOBE_2; pfam08402 137722015441 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 137722015442 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 137722015443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722015444 dimer interface [polypeptide binding]; other site 137722015445 conserved gate region; other site 137722015446 putative PBP binding loops; other site 137722015447 ABC-ATPase subunit interface; other site 137722015448 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722015449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722015450 dimer interface [polypeptide binding]; other site 137722015451 conserved gate region; other site 137722015452 putative PBP binding loops; other site 137722015453 ABC-ATPase subunit interface; other site 137722015454 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 137722015455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722015456 non-specific DNA binding site [nucleotide binding]; other site 137722015457 salt bridge; other site 137722015458 sequence-specific DNA binding site [nucleotide binding]; other site 137722015459 Cupin domain; Region: Cupin_2; pfam07883 137722015460 succinic semialdehyde dehydrogenase; Region: PLN02278 137722015461 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 137722015462 tetramerization interface [polypeptide binding]; other site 137722015463 NAD(P) binding site [chemical binding]; other site 137722015464 catalytic residues [active] 137722015465 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 137722015466 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 137722015467 inhibitor-cofactor binding pocket; inhibition site 137722015468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722015469 catalytic residue [active] 137722015470 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 137722015471 CoA-transferase family III; Region: CoA_transf_3; pfam02515 137722015472 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 137722015473 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 137722015474 putative NAD(P) binding site [chemical binding]; other site 137722015475 catalytic Zn binding site [ion binding]; other site 137722015476 structural Zn binding site [ion binding]; other site 137722015477 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722015478 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 137722015479 putative DNA binding site [nucleotide binding]; other site 137722015480 putative Zn2+ binding site [ion binding]; other site 137722015481 AsnC family; Region: AsnC_trans_reg; pfam01037 137722015482 CHASE3 domain; Region: CHASE3; pfam05227 137722015483 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 137722015484 HAMP domain; Region: HAMP; pfam00672 137722015485 dimerization interface [polypeptide binding]; other site 137722015486 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722015487 dimer interface [polypeptide binding]; other site 137722015488 putative CheW interface [polypeptide binding]; other site 137722015489 CHASE3 domain; Region: CHASE3; pfam05227 137722015490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015491 dimerization interface [polypeptide binding]; other site 137722015492 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722015493 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722015494 dimer interface [polypeptide binding]; other site 137722015495 putative CheW interface [polypeptide binding]; other site 137722015496 EamA-like transporter family; Region: EamA; pfam00892 137722015497 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 137722015498 AsmA family; Region: AsmA; pfam05170 137722015499 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 137722015500 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 137722015501 transmembrane helices; other site 137722015502 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 137722015503 TrkA-C domain; Region: TrkA_C; pfam02080 137722015504 TrkA-C domain; Region: TrkA_C; pfam02080 137722015505 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 137722015506 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 137722015507 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722015508 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722015509 dimer interface [polypeptide binding]; other site 137722015510 putative CheW interface [polypeptide binding]; other site 137722015511 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722015512 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722015513 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722015514 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722015515 hypothetical protein; Provisional; Region: PRK08912 137722015516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722015517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722015518 homodimer interface [polypeptide binding]; other site 137722015519 catalytic residue [active] 137722015520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722015521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722015522 dimer interface [polypeptide binding]; other site 137722015523 phosphorylation site [posttranslational modification] 137722015524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722015525 ATP binding site [chemical binding]; other site 137722015526 Mg2+ binding site [ion binding]; other site 137722015527 G-X-G motif; other site 137722015528 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 137722015529 MG2 domain; Region: A2M_N; pfam01835 137722015530 Alpha-2-macroglobulin family; Region: A2M; pfam00207 137722015531 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 137722015532 surface patch; other site 137722015533 thioester region; other site 137722015534 specificity defining residues; other site 137722015535 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 137722015536 DNA binding residues [nucleotide binding] 137722015537 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 137722015538 putative dimer interface [polypeptide binding]; other site 137722015539 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 137722015540 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 137722015541 dimer interface [polypeptide binding]; other site 137722015542 active site 137722015543 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 137722015544 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 137722015545 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722015546 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722015547 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 137722015548 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722015549 substrate binding site [chemical binding]; other site 137722015550 oxyanion hole (OAH) forming residues; other site 137722015551 trimer interface [polypeptide binding]; other site 137722015552 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 137722015553 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 137722015554 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722015555 active site 137722015556 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 137722015557 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722015558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722015559 active site 137722015560 phosphorylation site [posttranslational modification] 137722015561 intermolecular recognition site; other site 137722015562 dimerization interface [polypeptide binding]; other site 137722015563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722015564 dimerization interface [polypeptide binding]; other site 137722015565 DNA binding residues [nucleotide binding] 137722015566 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 137722015567 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 137722015568 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 137722015569 hydroxyglutarate oxidase; Provisional; Region: PRK11728 137722015570 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 137722015571 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 137722015572 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 137722015573 minor groove reading motif; other site 137722015574 helix-hairpin-helix signature motif; other site 137722015575 substrate binding pocket [chemical binding]; other site 137722015576 active site 137722015577 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 137722015578 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 137722015579 DNA binding and oxoG recognition site [nucleotide binding] 137722015580 Protein of unknown function (DUF721); Region: DUF721; cl02324 137722015581 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 137722015582 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 137722015583 catalytic residues [active] 137722015584 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 137722015585 AAA domain; Region: AAA_23; pfam13476 137722015586 Walker A/P-loop; other site 137722015587 ATP binding site [chemical binding]; other site 137722015588 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 137722015589 ABC transporter signature motif; other site 137722015590 Walker B; other site 137722015591 D-loop; other site 137722015592 H-loop/switch region; other site 137722015593 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722015594 Walker A/P-loop; other site 137722015595 ATP binding site [chemical binding]; other site 137722015596 AAA domain; Region: AAA_21; pfam13304 137722015597 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 137722015598 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 137722015599 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 137722015600 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 137722015601 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 137722015602 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 137722015603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722015604 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722015605 substrate binding pocket [chemical binding]; other site 137722015606 membrane-bound complex binding site; other site 137722015607 hinge residues; other site 137722015608 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 137722015609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722015610 putative PBP binding loops; other site 137722015611 dimer interface [polypeptide binding]; other site 137722015612 ABC-ATPase subunit interface; other site 137722015613 Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913 137722015614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722015615 FeS/SAM binding site; other site 137722015616 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 137722015617 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 137722015618 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 137722015619 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 137722015620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722015621 Walker A/P-loop; other site 137722015622 ATP binding site [chemical binding]; other site 137722015623 Q-loop/lid; other site 137722015624 ABC transporter signature motif; other site 137722015625 Walker B; other site 137722015626 D-loop; other site 137722015627 H-loop/switch region; other site 137722015628 TOBE domain; Region: TOBE_2; pfam08402 137722015629 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 137722015630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722015631 dimer interface [polypeptide binding]; other site 137722015632 conserved gate region; other site 137722015633 putative PBP binding loops; other site 137722015634 ABC-ATPase subunit interface; other site 137722015635 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722015636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722015637 dimer interface [polypeptide binding]; other site 137722015638 conserved gate region; other site 137722015639 putative PBP binding loops; other site 137722015640 ABC-ATPase subunit interface; other site 137722015641 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 137722015642 agmatine deiminase; Region: agmatine_aguA; TIGR03380 137722015643 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 137722015644 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 137722015645 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 137722015646 alpha subunit interaction interface [polypeptide binding]; other site 137722015647 Walker A motif; other site 137722015648 ATP binding site [chemical binding]; other site 137722015649 Walker B motif; other site 137722015650 inhibitor binding site; inhibition site 137722015651 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 137722015652 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 137722015653 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 137722015654 gamma subunit interface [polypeptide binding]; other site 137722015655 epsilon subunit interface [polypeptide binding]; other site 137722015656 LBP interface [polypeptide binding]; other site 137722015657 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 137722015658 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 137722015659 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 137722015660 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 137722015661 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 137722015662 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 137722015663 Walker A motif; other site 137722015664 ATP binding site [chemical binding]; other site 137722015665 Walker B motif; other site 137722015666 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 137722015667 core domain interface [polypeptide binding]; other site 137722015668 delta subunit interface [polypeptide binding]; other site 137722015669 epsilon subunit interface [polypeptide binding]; other site 137722015670 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 137722015671 aldehyde dehydrogenase family 7 member; Region: PLN02315 137722015672 tetrameric interface [polypeptide binding]; other site 137722015673 NAD binding site [chemical binding]; other site 137722015674 catalytic residues [active] 137722015675 thiamine pyrophosphate protein; Validated; Region: PRK08199 137722015676 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 137722015677 PYR/PP interface [polypeptide binding]; other site 137722015678 dimer interface [polypeptide binding]; other site 137722015679 TPP binding site [chemical binding]; other site 137722015680 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 137722015681 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 137722015682 TPP-binding site [chemical binding]; other site 137722015683 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 137722015684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722015685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722015686 dimerization interface [polypeptide binding]; other site 137722015687 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 137722015688 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 137722015689 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 137722015690 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 137722015691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722015692 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 137722015693 NAD(P) binding site [chemical binding]; other site 137722015694 active site 137722015695 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 137722015696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722015697 catalytic residue [active] 137722015698 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722015699 putative active site [active] 137722015700 heme pocket [chemical binding]; other site 137722015701 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722015702 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 137722015703 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 137722015704 active site 137722015705 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 137722015706 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722015707 dimerization interface [polypeptide binding]; other site 137722015708 putative DNA binding site [nucleotide binding]; other site 137722015709 putative Zn2+ binding site [ion binding]; other site 137722015710 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 137722015711 CPxP motif; other site 137722015712 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 137722015713 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 137722015714 putative active site [active] 137722015715 Zn binding site [ion binding]; other site 137722015716 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 137722015717 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 137722015718 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 137722015719 substrate binding pocket [chemical binding]; other site 137722015720 chain length determination region; other site 137722015721 substrate-Mg2+ binding site; other site 137722015722 catalytic residues [active] 137722015723 aspartate-rich region 1; other site 137722015724 active site lid residues [active] 137722015725 aspartate-rich region 2; other site 137722015726 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 137722015727 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 137722015728 TPP-binding site; other site 137722015729 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 137722015730 PYR/PP interface [polypeptide binding]; other site 137722015731 dimer interface [polypeptide binding]; other site 137722015732 TPP binding site [chemical binding]; other site 137722015733 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 137722015734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 137722015735 Histidine kinase; Region: HisKA_2; pfam07568 137722015736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722015737 ATP binding site [chemical binding]; other site 137722015738 Mg2+ binding site [ion binding]; other site 137722015739 G-X-G motif; other site 137722015740 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 137722015741 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 137722015742 RNA binding surface [nucleotide binding]; other site 137722015743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722015744 S-adenosylmethionine binding site [chemical binding]; other site 137722015745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722015746 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722015747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722015748 transcriptional regulator; Provisional; Region: PRK10632 137722015749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722015750 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 137722015751 putative effector binding pocket; other site 137722015752 putative dimerization interface [polypeptide binding]; other site 137722015753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 137722015754 SnoaL-like domain; Region: SnoaL_2; pfam12680 137722015755 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 137722015756 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 137722015757 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 137722015758 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 137722015759 putative C-terminal domain interface [polypeptide binding]; other site 137722015760 putative GSH binding site (G-site) [chemical binding]; other site 137722015761 putative dimer interface [polypeptide binding]; other site 137722015762 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 137722015763 putative N-terminal domain interface [polypeptide binding]; other site 137722015764 putative dimer interface [polypeptide binding]; other site 137722015765 putative substrate binding pocket (H-site) [chemical binding]; other site 137722015766 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 137722015767 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 137722015768 NAD(P) binding site [chemical binding]; other site 137722015769 catalytic residues [active] 137722015770 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 137722015771 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 137722015772 catalytic Zn binding site [ion binding]; other site 137722015773 NAD binding site [chemical binding]; other site 137722015774 structural Zn binding site [ion binding]; other site 137722015775 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 137722015776 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 137722015777 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 137722015778 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 137722015779 Activator of aromatic catabolism; Region: XylR_N; pfam06505 137722015780 V4R domain; Region: V4R; pfam02830 137722015781 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 137722015782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722015783 Walker A motif; other site 137722015784 ATP binding site [chemical binding]; other site 137722015785 Walker B motif; other site 137722015786 Beta-lactamase; Region: Beta-lactamase; pfam00144 137722015787 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 137722015788 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 137722015789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722015790 active site 137722015791 phosphorylation site [posttranslational modification] 137722015792 intermolecular recognition site; other site 137722015793 dimerization interface [polypeptide binding]; other site 137722015794 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722015795 DNA binding residues [nucleotide binding] 137722015796 dimerization interface [polypeptide binding]; other site 137722015797 MASE1; Region: MASE1; cl17823 137722015798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722015799 dimer interface [polypeptide binding]; other site 137722015800 phosphorylation site [posttranslational modification] 137722015801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722015802 ATP binding site [chemical binding]; other site 137722015803 Mg2+ binding site [ion binding]; other site 137722015804 G-X-G motif; other site 137722015805 universal stress protein UspE; Provisional; Region: PRK11175 137722015806 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 137722015807 Ligand Binding Site [chemical binding]; other site 137722015808 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 137722015809 Ligand Binding Site [chemical binding]; other site 137722015810 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 137722015811 active site 137722015812 phosphorylation site [posttranslational modification] 137722015813 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 137722015814 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 137722015815 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 137722015816 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 137722015817 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 137722015818 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 137722015819 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 137722015820 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 137722015821 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 137722015822 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 137722015823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722015824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015825 dimerization interface [polypeptide binding]; other site 137722015826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722015827 dimer interface [polypeptide binding]; other site 137722015828 phosphorylation site [posttranslational modification] 137722015829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722015830 ATP binding site [chemical binding]; other site 137722015831 Mg2+ binding site [ion binding]; other site 137722015832 G-X-G motif; other site 137722015833 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722015834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722015835 active site 137722015836 phosphorylation site [posttranslational modification] 137722015837 intermolecular recognition site; other site 137722015838 dimerization interface [polypeptide binding]; other site 137722015839 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722015840 DNA binding site [nucleotide binding] 137722015841 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 137722015842 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722015843 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 137722015844 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 137722015845 Walker A/P-loop; other site 137722015846 ATP binding site [chemical binding]; other site 137722015847 Q-loop/lid; other site 137722015848 ABC transporter signature motif; other site 137722015849 Walker B; other site 137722015850 D-loop; other site 137722015851 H-loop/switch region; other site 137722015852 DevC protein; Region: devC; TIGR01185 137722015853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722015854 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 137722015855 NAD(P) binding site [chemical binding]; other site 137722015856 active site 137722015857 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 137722015858 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 137722015859 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 137722015860 Walker A/P-loop; other site 137722015861 ATP binding site [chemical binding]; other site 137722015862 Q-loop/lid; other site 137722015863 ABC transporter signature motif; other site 137722015864 Walker B; other site 137722015865 D-loop; other site 137722015866 H-loop/switch region; other site 137722015867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722015868 dimer interface [polypeptide binding]; other site 137722015869 conserved gate region; other site 137722015870 putative PBP binding loops; other site 137722015871 ABC-ATPase subunit interface; other site 137722015872 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722015873 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722015874 substrate binding pocket [chemical binding]; other site 137722015875 membrane-bound complex binding site; other site 137722015876 hinge residues; other site 137722015877 acetylglutamate kinase; Provisional; Region: PRK04531 137722015878 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 137722015879 nucleotide binding site [chemical binding]; other site 137722015880 substrate binding site [chemical binding]; other site 137722015881 DUF619 domain of various N-acetylglutamate Synthases of the fungal arginine-biosynthetic pathway and urea cycle found in humans and fish; Region: DUF619-NAGS; cd04264 137722015882 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 137722015883 MgtC family; Region: MgtC; pfam02308 137722015884 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 137722015885 Cation efflux family; Region: Cation_efflux; cl00316 137722015886 Cation efflux family; Region: Cation_efflux; cl00316 137722015887 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722015888 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722015889 Walker A/P-loop; other site 137722015890 ATP binding site [chemical binding]; other site 137722015891 Q-loop/lid; other site 137722015892 ABC transporter signature motif; other site 137722015893 Walker B; other site 137722015894 D-loop; other site 137722015895 H-loop/switch region; other site 137722015896 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 137722015897 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 137722015898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722015899 dimer interface [polypeptide binding]; other site 137722015900 conserved gate region; other site 137722015901 putative PBP binding loops; other site 137722015902 ABC-ATPase subunit interface; other site 137722015903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722015904 dimer interface [polypeptide binding]; other site 137722015905 conserved gate region; other site 137722015906 putative PBP binding loops; other site 137722015907 ABC-ATPase subunit interface; other site 137722015908 HAMP domain; Region: HAMP; pfam00672 137722015909 dimerization interface [polypeptide binding]; other site 137722015910 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722015911 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722015912 dimer interface [polypeptide binding]; other site 137722015913 putative CheW interface [polypeptide binding]; other site 137722015914 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 137722015915 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 137722015916 TMAO/DMSO reductase; Reviewed; Region: PRK05363 137722015917 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 137722015918 Moco binding site; other site 137722015919 metal coordination site [ion binding]; other site 137722015920 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 137722015921 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015922 dimerization interface [polypeptide binding]; other site 137722015923 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 137722015924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015925 dimerization interface [polypeptide binding]; other site 137722015926 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015927 dimerization interface [polypeptide binding]; other site 137722015928 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015929 dimerization interface [polypeptide binding]; other site 137722015930 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015931 dimerization interface [polypeptide binding]; other site 137722015932 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 137722015933 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015934 dimerization interface [polypeptide binding]; other site 137722015935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015936 dimerization interface [polypeptide binding]; other site 137722015937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015938 dimerization interface [polypeptide binding]; other site 137722015939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722015940 dimerization interface [polypeptide binding]; other site 137722015941 GAF domain; Region: GAF_2; pfam13185 137722015942 GAF domain; Region: GAF; pfam01590 137722015943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722015944 dimer interface [polypeptide binding]; other site 137722015945 phosphorylation site [posttranslational modification] 137722015946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722015947 ATP binding site [chemical binding]; other site 137722015948 Mg2+ binding site [ion binding]; other site 137722015949 G-X-G motif; other site 137722015950 Response regulator receiver domain; Region: Response_reg; pfam00072 137722015951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722015952 active site 137722015953 phosphorylation site [posttranslational modification] 137722015954 intermolecular recognition site; other site 137722015955 dimerization interface [polypeptide binding]; other site 137722015956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722015957 active site 137722015958 phosphorylation site [posttranslational modification] 137722015959 intermolecular recognition site; other site 137722015960 Response regulator receiver domain; Region: Response_reg; pfam00072 137722015961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722015962 active site 137722015963 phosphorylation site [posttranslational modification] 137722015964 intermolecular recognition site; other site 137722015965 dimerization interface [polypeptide binding]; other site 137722015966 Response regulator receiver domain; Region: Response_reg; pfam00072 137722015967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722015968 active site 137722015969 phosphorylation site [posttranslational modification] 137722015970 intermolecular recognition site; other site 137722015971 dimerization interface [polypeptide binding]; other site 137722015972 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722015973 PAS fold; Region: PAS_3; pfam08447 137722015974 putative active site [active] 137722015975 heme pocket [chemical binding]; other site 137722015976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 137722015977 dimer interface [polypeptide binding]; other site 137722015978 phosphorylation site [posttranslational modification] 137722015979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722015980 ATP binding site [chemical binding]; other site 137722015981 Mg2+ binding site [ion binding]; other site 137722015982 G-X-G motif; other site 137722015983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 137722015984 active site 137722015985 phosphorylation site [posttranslational modification] 137722015986 intermolecular recognition site; other site 137722015987 dimerization interface [polypeptide binding]; other site 137722015988 phosphoribosylglycinamide formyltransferase 2; Region: purT; TIGR01142 137722015989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722015990 ATP-grasp domain; Region: ATP-grasp; pfam02222 137722015991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722015992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722015993 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 137722015994 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 137722015995 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 137722015996 DctM-like transporters; Region: DctM; pfam06808 137722015997 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 137722015998 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 137722015999 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 137722016000 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 137722016001 shikimate binding site; other site 137722016002 NAD(P) binding site [chemical binding]; other site 137722016003 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 137722016004 Dehydroquinase class II; Region: DHquinase_II; pfam01220 137722016005 active site 137722016006 trimer interface [polypeptide binding]; other site 137722016007 dimer interface [polypeptide binding]; other site 137722016008 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 137722016009 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 137722016010 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 137722016011 dimer interface [polypeptide binding]; other site 137722016012 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 137722016013 active site 137722016014 Fe binding site [ion binding]; other site 137722016015 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 137722016016 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 137722016017 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 137722016018 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 137722016019 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722016020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722016021 dimer interface [polypeptide binding]; other site 137722016022 putative CheW interface [polypeptide binding]; other site 137722016023 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 137722016024 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 137722016025 homodimer interface [polypeptide binding]; other site 137722016026 metal binding site [ion binding]; metal-binding site 137722016027 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 137722016028 homodimer interface [polypeptide binding]; other site 137722016029 active site 137722016030 putative chemical substrate binding site [chemical binding]; other site 137722016031 metal binding site [ion binding]; metal-binding site 137722016032 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722016033 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722016034 metal binding site [ion binding]; metal-binding site 137722016035 active site 137722016036 I-site; other site 137722016037 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 137722016038 Helix-turn-helix domain; Region: HTH_38; pfam13936 137722016039 Homeodomain-like domain; Region: HTH_32; pfam13565 137722016040 Integrase core domain; Region: rve; pfam00665 137722016041 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 137722016042 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 137722016043 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 137722016044 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 137722016045 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 137722016046 dimer interface [polypeptide binding]; other site 137722016047 active site 137722016048 glycine-pyridoxal phosphate binding site [chemical binding]; other site 137722016049 folate binding site [chemical binding]; other site 137722016050 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 137722016051 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 137722016052 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 137722016053 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 137722016054 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 137722016055 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 137722016056 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 137722016057 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 137722016058 conserved cys residue [active] 137722016059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722016060 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 137722016061 putative deacylase active site [active] 137722016062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722016063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722016064 putative substrate translocation pore; other site 137722016065 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 137722016066 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 137722016067 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 137722016068 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 137722016069 [2Fe-2S] cluster binding site [ion binding]; other site 137722016070 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 137722016071 putative alpha subunit interface [polypeptide binding]; other site 137722016072 putative active site [active] 137722016073 putative substrate binding site [chemical binding]; other site 137722016074 Fe binding site [ion binding]; other site 137722016075 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 137722016076 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 137722016077 FAD binding pocket [chemical binding]; other site 137722016078 FAD binding motif [chemical binding]; other site 137722016079 phosphate binding motif [ion binding]; other site 137722016080 beta-alpha-beta structure motif; other site 137722016081 NAD binding pocket [chemical binding]; other site 137722016082 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722016083 catalytic loop [active] 137722016084 iron binding site [ion binding]; other site 137722016085 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 137722016086 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 137722016087 conserved cys residue [active] 137722016088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722016089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722016090 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 137722016091 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 137722016092 putative active site [active] 137722016093 putative FMN binding site [chemical binding]; other site 137722016094 putative substrate binding site [chemical binding]; other site 137722016095 putative catalytic residue [active] 137722016096 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 137722016097 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 137722016098 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 137722016099 4Fe-4S binding domain; Region: Fer4; cl02805 137722016100 Cysteine-rich domain; Region: CCG; pfam02754 137722016101 Cysteine-rich domain; Region: CCG; pfam02754 137722016102 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 137722016103 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 137722016104 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 137722016105 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 137722016106 Electron transfer flavoprotein domain; Region: ETF; pfam01012 137722016107 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 137722016108 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 137722016109 Walker A/P-loop; other site 137722016110 ATP binding site [chemical binding]; other site 137722016111 Q-loop/lid; other site 137722016112 ABC transporter signature motif; other site 137722016113 Walker B; other site 137722016114 D-loop; other site 137722016115 H-loop/switch region; other site 137722016116 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 137722016117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722016118 dimer interface [polypeptide binding]; other site 137722016119 conserved gate region; other site 137722016120 putative PBP binding loops; other site 137722016121 ABC-ATPase subunit interface; other site 137722016122 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 137722016123 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 137722016124 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 137722016125 conserved cys residue [active] 137722016126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722016127 Dihydroneopterin aldolase; Region: FolB; smart00905 137722016128 active site 137722016129 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 137722016130 nucleotide binding site [chemical binding]; other site 137722016131 substrate binding site [chemical binding]; other site 137722016132 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 137722016133 nickel binding site [ion binding]; other site 137722016134 putative substrate-binding site; other site 137722016135 HupF/HypC family; Region: HupF_HypC; pfam01455 137722016136 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 137722016137 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 137722016138 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 137722016139 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 137722016140 Rubredoxin; Region: Rubredoxin; pfam00301 137722016141 iron binding site [ion binding]; other site 137722016142 Protein of unknown function (DUF3457); Region: DUF3457; pfam11939 137722016143 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 137722016144 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 137722016145 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 137722016146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722016147 active site 137722016148 phosphorylation site [posttranslational modification] 137722016149 intermolecular recognition site; other site 137722016150 dimerization interface [polypeptide binding]; other site 137722016151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722016152 Walker A motif; other site 137722016153 ATP binding site [chemical binding]; other site 137722016154 Walker B motif; other site 137722016155 arginine finger; other site 137722016156 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722016157 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 137722016158 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 137722016159 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 137722016160 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 137722016161 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 137722016162 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 137722016163 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 137722016164 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 137722016165 Acylphosphatase; Region: Acylphosphatase; pfam00708 137722016166 HypF finger; Region: zf-HYPF; pfam07503 137722016167 HypF finger; Region: zf-HYPF; pfam07503 137722016168 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 137722016169 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 137722016170 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 137722016171 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 137722016172 MPT binding site; other site 137722016173 trimer interface [polypeptide binding]; other site 137722016174 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 137722016175 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 137722016176 metal ion-dependent adhesion site (MIDAS); other site 137722016177 MoxR-like ATPases [General function prediction only]; Region: COG0714 137722016178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722016179 Walker A motif; other site 137722016180 ATP binding site [chemical binding]; other site 137722016181 Walker B motif; other site 137722016182 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 137722016183 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 137722016184 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 137722016185 Low-spin heme binding site [chemical binding]; other site 137722016186 D-pathway; other site 137722016187 K-pathway; other site 137722016188 Binuclear center (active site) [active] 137722016189 Putative proton exit pathway; other site 137722016190 Cytochrome c; Region: Cytochrom_C; pfam00034 137722016191 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 137722016192 Subunit I/III interface [polypeptide binding]; other site 137722016193 AAA domain; Region: AAA_17; pfam13207 137722016194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 137722016195 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 137722016196 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 137722016197 kynureninase; Region: kynureninase; TIGR01814 137722016198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722016199 catalytic residue [active] 137722016200 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 137722016201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722016202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722016203 homodimer interface [polypeptide binding]; other site 137722016204 catalytic residue [active] 137722016205 Uncharacterized conserved protein [Function unknown]; Region: COG1284 137722016206 hypothetical protein; Provisional; Region: PRK01617 137722016207 SEC-C motif; Region: SEC-C; pfam02810 137722016208 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 137722016209 Zn2+ binding site [ion binding]; other site 137722016210 Mg2+ binding site [ion binding]; other site 137722016211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722016212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722016213 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 137722016214 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 137722016215 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722016216 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722016217 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 137722016218 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 137722016219 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 137722016220 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 137722016221 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 137722016222 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 137722016223 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 137722016224 DctM-like transporters; Region: DctM; pfam06808 137722016225 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 137722016226 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 137722016227 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 137722016228 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722016229 catalytic loop [active] 137722016230 iron binding site [ion binding]; other site 137722016231 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 137722016232 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 137722016233 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 137722016234 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 137722016235 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 137722016236 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 137722016237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722016238 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 137722016239 Walker A motif; other site 137722016240 ATP binding site [chemical binding]; other site 137722016241 Walker B motif; other site 137722016242 arginine finger; other site 137722016243 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 137722016244 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 137722016245 metal ion-dependent adhesion site (MIDAS); other site 137722016246 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 137722016247 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 137722016248 XdhC Rossmann domain; Region: XdhC_C; pfam13478 137722016249 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 137722016250 putative MPT binding site; other site 137722016251 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 137722016252 Ligand binding site; other site 137722016253 metal-binding site 137722016254 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 137722016255 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 137722016256 catalytic triad [active] 137722016257 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 137722016258 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 137722016259 active site 137722016260 metal binding site [ion binding]; metal-binding site 137722016261 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 137722016262 Putative phosphatase (DUF442); Region: DUF442; cl17385 137722016263 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 137722016264 Uncharacterized conserved protein [Function unknown]; Region: COG1284 137722016265 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 137722016266 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 137722016267 tetramer interface [polypeptide binding]; other site 137722016268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722016269 catalytic residue [active] 137722016270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722016271 active site 137722016272 phosphorylation site [posttranslational modification] 137722016273 intermolecular recognition site; other site 137722016274 PAS fold; Region: PAS; pfam00989 137722016275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 137722016276 putative active site [active] 137722016277 heme pocket [chemical binding]; other site 137722016278 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722016279 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722016280 metal binding site [ion binding]; metal-binding site 137722016281 active site 137722016282 I-site; other site 137722016283 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 137722016284 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 137722016285 peptide binding site [polypeptide binding]; other site 137722016286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722016287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722016288 ATP binding site [chemical binding]; other site 137722016289 Mg2+ binding site [ion binding]; other site 137722016290 G-X-G motif; other site 137722016291 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722016292 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722016293 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722016294 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722016295 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 137722016296 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 137722016297 transcriptional regulator BetI; Validated; Region: PRK00767 137722016298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722016299 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 137722016300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722016301 dimer interface [polypeptide binding]; other site 137722016302 conserved gate region; other site 137722016303 putative PBP binding loops; other site 137722016304 ABC-ATPase subunit interface; other site 137722016305 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 137722016306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722016307 Walker A/P-loop; other site 137722016308 ATP binding site [chemical binding]; other site 137722016309 Q-loop/lid; other site 137722016310 ABC transporter signature motif; other site 137722016311 Walker B; other site 137722016312 D-loop; other site 137722016313 H-loop/switch region; other site 137722016314 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 137722016315 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 137722016316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722016317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722016318 DNA binding residues [nucleotide binding] 137722016319 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 137722016320 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 137722016321 Predicted acetyltransferase [General function prediction only]; Region: COG2388 137722016322 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 137722016323 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 137722016324 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722016325 catalytic residue [active] 137722016326 Imelysin; Region: Peptidase_M75; cl09159 137722016327 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 137722016328 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 137722016329 Multicopper oxidase; Region: Cu-oxidase; pfam00394 137722016330 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 137722016331 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 137722016332 Imelysin; Region: Peptidase_M75; pfam09375 137722016333 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 137722016334 S-formylglutathione hydrolase; Region: PLN02442 137722016335 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 137722016336 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 137722016337 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 137722016338 substrate binding site [chemical binding]; other site 137722016339 catalytic Zn binding site [ion binding]; other site 137722016340 NAD binding site [chemical binding]; other site 137722016341 structural Zn binding site [ion binding]; other site 137722016342 dimer interface [polypeptide binding]; other site 137722016343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722016344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722016345 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722016346 dimerization interface [polypeptide binding]; other site 137722016347 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 137722016348 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 137722016349 active site 137722016350 P-loop; other site 137722016351 phosphorylation site [posttranslational modification] 137722016352 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 137722016353 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 137722016354 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 137722016355 putative substrate binding site [chemical binding]; other site 137722016356 putative ATP binding site [chemical binding]; other site 137722016357 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 137722016358 active site 137722016359 phosphorylation site [posttranslational modification] 137722016360 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 137722016361 dimerization domain swap beta strand [polypeptide binding]; other site 137722016362 regulatory protein interface [polypeptide binding]; other site 137722016363 active site 137722016364 regulatory phosphorylation site [posttranslational modification]; other site 137722016365 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 137722016366 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 137722016367 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 137722016368 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 137722016369 Transcriptional regulators [Transcription]; Region: PurR; COG1609 137722016370 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 137722016371 DNA binding site [nucleotide binding] 137722016372 domain linker motif; other site 137722016373 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 137722016374 putative dimerization interface [polypeptide binding]; other site 137722016375 putative ligand binding site [chemical binding]; other site 137722016376 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 137722016377 Chain length determinant protein; Region: Wzz; pfam02706 137722016378 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 137722016379 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 137722016380 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 137722016381 Nucleotide binding site [chemical binding]; other site 137722016382 P loop; other site 137722016383 DTAP/Switch II; other site 137722016384 Switch I; other site 137722016385 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722016386 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 137722016387 putative ADP-binding pocket [chemical binding]; other site 137722016388 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 137722016389 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 137722016390 active site 137722016391 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 137722016392 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722016393 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 137722016394 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 137722016395 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722016396 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 137722016397 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 137722016398 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 137722016399 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722016400 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722016401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722016402 DNA binding residues [nucleotide binding] 137722016403 dimerization interface [polypeptide binding]; other site 137722016404 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 137722016405 Transcriptional regulator [Transcription]; Region: IclR; COG1414 137722016406 Bacterial transcriptional regulator; Region: IclR; pfam01614 137722016407 PAS domain S-box; Region: sensory_box; TIGR00229 137722016408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722016409 putative active site [active] 137722016410 heme pocket [chemical binding]; other site 137722016411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722016412 PAS domain; Region: PAS_9; pfam13426 137722016413 putative active site [active] 137722016414 heme pocket [chemical binding]; other site 137722016415 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722016416 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722016417 metal binding site [ion binding]; metal-binding site 137722016418 active site 137722016419 I-site; other site 137722016420 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722016421 Zinc-finger domain; Region: zf-CHCC; pfam10276 137722016422 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 137722016423 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 137722016424 Walker A/P-loop; other site 137722016425 ATP binding site [chemical binding]; other site 137722016426 Q-loop/lid; other site 137722016427 ABC transporter signature motif; other site 137722016428 Walker B; other site 137722016429 D-loop; other site 137722016430 H-loop/switch region; other site 137722016431 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 137722016432 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 137722016433 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 137722016434 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 137722016435 active site 137722016436 catalytic site [active] 137722016437 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 137722016438 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 137722016439 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 137722016440 active site 137722016441 homodimer interface [polypeptide binding]; other site 137722016442 catalytic site [active] 137722016443 acceptor binding site [chemical binding]; other site 137722016444 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 137722016445 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 137722016446 GAF domain; Region: GAF; pfam01590 137722016447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722016448 Walker A motif; other site 137722016449 ATP binding site [chemical binding]; other site 137722016450 Walker B motif; other site 137722016451 arginine finger; other site 137722016452 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722016453 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 137722016454 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 137722016455 ring oligomerisation interface [polypeptide binding]; other site 137722016456 ATP/Mg binding site [chemical binding]; other site 137722016457 stacking interactions; other site 137722016458 hinge regions; other site 137722016459 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 137722016460 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 137722016461 dimerization interface [polypeptide binding]; other site 137722016462 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 137722016463 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722016464 catalytic loop [active] 137722016465 iron binding site [ion binding]; other site 137722016466 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 137722016467 FAD binding pocket [chemical binding]; other site 137722016468 FAD binding motif [chemical binding]; other site 137722016469 phosphate binding motif [ion binding]; other site 137722016470 beta-alpha-beta structure motif; other site 137722016471 NAD binding pocket [chemical binding]; other site 137722016472 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 137722016473 dimerization interface [polypeptide binding]; other site 137722016474 putative path to active site cavity [active] 137722016475 diiron center [ion binding]; other site 137722016476 Cytochrome c; Region: Cytochrom_C; cl11414 137722016477 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 137722016478 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 137722016479 dimer interface [polypeptide binding]; other site 137722016480 active site 137722016481 metal binding site [ion binding]; metal-binding site 137722016482 glutathione binding site [chemical binding]; other site 137722016483 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 137722016484 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 137722016485 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 137722016486 citrate-proton symporter; Provisional; Region: PRK15075 137722016487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722016488 putative substrate translocation pore; other site 137722016489 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 137722016490 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 137722016491 Response regulator receiver domain; Region: Response_reg; pfam00072 137722016492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722016493 active site 137722016494 phosphorylation site [posttranslational modification] 137722016495 intermolecular recognition site; other site 137722016496 dimerization interface [polypeptide binding]; other site 137722016497 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 137722016498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722016499 active site 137722016500 phosphorylation site [posttranslational modification] 137722016501 intermolecular recognition site; other site 137722016502 dimerization interface [polypeptide binding]; other site 137722016503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722016504 DNA binding residues [nucleotide binding] 137722016505 dimerization interface [polypeptide binding]; other site 137722016506 PAS domain; Region: PAS_9; pfam13426 137722016507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 137722016508 dimer interface [polypeptide binding]; other site 137722016509 phosphorylation site [posttranslational modification] 137722016510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722016511 ATP binding site [chemical binding]; other site 137722016512 Mg2+ binding site [ion binding]; other site 137722016513 G-X-G motif; other site 137722016514 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722016515 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 137722016516 catalytic loop [active] 137722016517 iron binding site [ion binding]; other site 137722016518 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 137722016519 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 137722016520 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 137722016521 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 137722016522 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 137722016523 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 137722016524 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 137722016525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722016526 putative substrate translocation pore; other site 137722016527 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 137722016528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722016529 NAD(P) binding site [chemical binding]; other site 137722016530 active site 137722016531 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 137722016532 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 137722016533 conserved cys residue [active] 137722016534 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722016535 Uncharacterized conserved protein [Function unknown]; Region: COG1359 137722016536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722016537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722016538 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 137722016539 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 137722016540 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722016541 LysR family transcriptional regulator; Provisional; Region: PRK14997 137722016542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722016543 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 137722016544 putative effector binding pocket; other site 137722016545 dimerization interface [polypeptide binding]; other site 137722016546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722016547 short chain dehydrogenase; Provisional; Region: PRK07041 137722016548 NAD(P) binding site [chemical binding]; other site 137722016549 active site 137722016550 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 137722016551 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 137722016552 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 137722016553 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 137722016554 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 137722016555 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 137722016556 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 137722016557 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 137722016558 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 137722016559 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 137722016560 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 137722016561 acetylornithine deacetylase; Provisional; Region: PRK07522 137722016562 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 137722016563 metal binding site [ion binding]; metal-binding site 137722016564 putative dimer interface [polypeptide binding]; other site 137722016565 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 137722016566 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 137722016567 putative ligand binding site [chemical binding]; other site 137722016568 NAD binding site [chemical binding]; other site 137722016569 dimerization interface [polypeptide binding]; other site 137722016570 catalytic site [active] 137722016571 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 137722016572 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 137722016573 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 137722016574 NAD(P) binding site [chemical binding]; other site 137722016575 catalytic residues [active] 137722016576 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 137722016577 tartrate dehydrogenase; Region: TTC; TIGR02089 137722016578 succinic semialdehyde dehydrogenase; Region: PLN02278 137722016579 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 137722016580 tetramerization interface [polypeptide binding]; other site 137722016581 NAD(P) binding site [chemical binding]; other site 137722016582 catalytic residues [active] 137722016583 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 137722016584 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 137722016585 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 137722016586 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 137722016587 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 137722016588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722016589 Coenzyme A binding pocket [chemical binding]; other site 137722016590 hypothetical protein; Provisional; Region: PRK05965 137722016591 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 137722016592 inhibitor-cofactor binding pocket; inhibition site 137722016593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722016594 catalytic residue [active] 137722016595 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 137722016596 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 137722016597 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 137722016598 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 137722016599 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 137722016600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722016601 dimer interface [polypeptide binding]; other site 137722016602 conserved gate region; other site 137722016603 putative PBP binding loops; other site 137722016604 ABC-ATPase subunit interface; other site 137722016605 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 137722016606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722016607 dimer interface [polypeptide binding]; other site 137722016608 conserved gate region; other site 137722016609 ABC-ATPase subunit interface; other site 137722016610 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 137722016611 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722016612 Walker A/P-loop; other site 137722016613 ATP binding site [chemical binding]; other site 137722016614 Q-loop/lid; other site 137722016615 ABC transporter signature motif; other site 137722016616 Walker B; other site 137722016617 D-loop; other site 137722016618 H-loop/switch region; other site 137722016619 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722016620 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722016621 Walker A/P-loop; other site 137722016622 ATP binding site [chemical binding]; other site 137722016623 Q-loop/lid; other site 137722016624 ABC transporter signature motif; other site 137722016625 Walker B; other site 137722016626 D-loop; other site 137722016627 H-loop/switch region; other site 137722016628 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722016629 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722016630 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722016631 putative DNA binding site [nucleotide binding]; other site 137722016632 putative Zn2+ binding site [ion binding]; other site 137722016633 AsnC family; Region: AsnC_trans_reg; pfam01037 137722016634 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 137722016635 hydroxyglutarate oxidase; Provisional; Region: PRK11728 137722016636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722016637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722016638 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 137722016639 putative dimerization interface [polypeptide binding]; other site 137722016640 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 137722016641 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 137722016642 Walker A/P-loop; other site 137722016643 ATP binding site [chemical binding]; other site 137722016644 Q-loop/lid; other site 137722016645 ABC transporter signature motif; other site 137722016646 Walker B; other site 137722016647 D-loop; other site 137722016648 H-loop/switch region; other site 137722016649 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 137722016650 BioY family; Region: BioY; pfam02632 137722016651 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 137722016652 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722016653 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722016654 acyl-activating enzyme (AAE) consensus motif; other site 137722016655 acyl-activating enzyme (AAE) consensus motif; other site 137722016656 AMP binding site [chemical binding]; other site 137722016657 active site 137722016658 CoA binding site [chemical binding]; other site 137722016659 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 137722016660 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 137722016661 dimer interface [polypeptide binding]; other site 137722016662 active site 137722016663 H+ Antiporter protein; Region: 2A0121; TIGR00900 137722016664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722016665 putative substrate translocation pore; other site 137722016666 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 137722016667 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 137722016668 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 137722016669 Walker A/P-loop; other site 137722016670 ATP binding site [chemical binding]; other site 137722016671 Q-loop/lid; other site 137722016672 ABC transporter signature motif; other site 137722016673 Walker B; other site 137722016674 D-loop; other site 137722016675 H-loop/switch region; other site 137722016676 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 137722016677 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 137722016678 FtsX-like permease family; Region: FtsX; pfam02687 137722016679 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722016680 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722016681 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 137722016682 dimer interface [polypeptide binding]; other site 137722016683 Alkaline phosphatase homologues; Region: alkPPc; smart00098 137722016684 active site 137722016685 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 137722016686 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 137722016687 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 137722016688 Walker A/P-loop; other site 137722016689 ATP binding site [chemical binding]; other site 137722016690 Q-loop/lid; other site 137722016691 ABC transporter signature motif; other site 137722016692 Walker B; other site 137722016693 D-loop; other site 137722016694 H-loop/switch region; other site 137722016695 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 137722016696 FtsX-like permease family; Region: FtsX; pfam02687 137722016697 Transcriptional regulators [Transcription]; Region: PurR; COG1609 137722016698 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 137722016699 DNA binding site [nucleotide binding] 137722016700 domain linker motif; other site 137722016701 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 137722016702 putative dimerization interface [polypeptide binding]; other site 137722016703 putative ligand binding site [chemical binding]; other site 137722016704 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722016705 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722016706 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 137722016707 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 137722016708 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722016709 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722016710 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722016711 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722016712 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 137722016713 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 137722016714 active site pocket [active] 137722016715 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 137722016716 inner membrane protein; Provisional; Region: PRK11715 137722016717 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722016718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722016719 active site 137722016720 phosphorylation site [posttranslational modification] 137722016721 intermolecular recognition site; other site 137722016722 dimerization interface [polypeptide binding]; other site 137722016723 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722016724 DNA binding site [nucleotide binding] 137722016725 sensory histidine kinase CreC; Provisional; Region: PRK11100 137722016726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722016727 dimer interface [polypeptide binding]; other site 137722016728 phosphorylation site [posttranslational modification] 137722016729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722016730 ATP binding site [chemical binding]; other site 137722016731 Mg2+ binding site [ion binding]; other site 137722016732 G-X-G motif; other site 137722016733 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 137722016734 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 137722016735 Walker A/P-loop; other site 137722016736 ATP binding site [chemical binding]; other site 137722016737 Q-loop/lid; other site 137722016738 ABC transporter signature motif; other site 137722016739 Walker B; other site 137722016740 D-loop; other site 137722016741 H-loop/switch region; other site 137722016742 ABC-2 type transporter; Region: ABC2_membrane; cl17235 137722016743 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 137722016744 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722016745 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 137722016746 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722016747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722016748 active site 137722016749 phosphorylation site [posttranslational modification] 137722016750 intermolecular recognition site; other site 137722016751 dimerization interface [polypeptide binding]; other site 137722016752 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 137722016753 DNA binding site [nucleotide binding] 137722016754 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 137722016755 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 137722016756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722016757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722016758 dimer interface [polypeptide binding]; other site 137722016759 phosphorylation site [posttranslational modification] 137722016760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722016761 ATP binding site [chemical binding]; other site 137722016762 Mg2+ binding site [ion binding]; other site 137722016763 G-X-G motif; other site 137722016764 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 137722016765 Sulfatase; Region: Sulfatase; cl17466 137722016766 Sulfatase; Region: Sulfatase; cl17466 137722016767 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722016768 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722016769 dimer interface [polypeptide binding]; other site 137722016770 putative CheW interface [polypeptide binding]; other site 137722016771 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 137722016772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722016773 NAD(P) binding site [chemical binding]; other site 137722016774 active site 137722016775 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 137722016776 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 137722016777 FMN-binding pocket [chemical binding]; other site 137722016778 flavin binding motif; other site 137722016779 phosphate binding motif [ion binding]; other site 137722016780 beta-alpha-beta structure motif; other site 137722016781 NAD binding pocket [chemical binding]; other site 137722016782 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722016783 catalytic loop [active] 137722016784 iron binding site [ion binding]; other site 137722016785 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 137722016786 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 137722016787 iron-sulfur cluster [ion binding]; other site 137722016788 [2Fe-2S] cluster binding site [ion binding]; other site 137722016789 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 137722016790 alpha subunit interface [polypeptide binding]; other site 137722016791 active site 137722016792 substrate binding site [chemical binding]; other site 137722016793 Fe binding site [ion binding]; other site 137722016794 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 137722016795 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 137722016796 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 137722016797 Putative cyclase; Region: Cyclase; pfam04199 137722016798 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 137722016799 hypothetical protein; Provisional; Region: PRK06847 137722016800 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 137722016801 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 137722016802 iron-sulfur cluster [ion binding]; other site 137722016803 [2Fe-2S] cluster binding site [ion binding]; other site 137722016804 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 137722016805 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 137722016806 putative active site [active] 137722016807 putative metal binding site [ion binding]; other site 137722016808 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 137722016809 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 137722016810 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 137722016811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722016812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722016813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722016814 dimerization interface [polypeptide binding]; other site 137722016815 Transposase; Region: HTH_Tnp_1; cl17663 137722016816 Winged helix-turn helix; Region: HTH_29; pfam13551 137722016817 Integrase core domain; Region: rve; pfam00665 137722016818 Integrase core domain; Region: rve_3; pfam13683 137722016819 HTH-like domain; Region: HTH_21; pfam13276 137722016820 Transposase; Region: HTH_Tnp_1; cl17663 137722016821 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722016822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722016823 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722016824 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722016825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722016826 Integrase core domain; Region: rve; pfam00665 137722016827 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722016828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722016829 Walker A motif; other site 137722016830 ATP binding site [chemical binding]; other site 137722016831 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722016832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722016833 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722016834 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722016835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722016836 Transposase; Region: HTH_Tnp_1; pfam01527 137722016837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722016838 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722016839 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722016840 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 137722016841 catalytic residues [active] 137722016842 catalytic nucleophile [active] 137722016843 Recombinase; Region: Recombinase; pfam07508 137722016844 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 137722016845 Helix-turn-helix domain; Region: HTH_17; pfam12728 137722016846 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722016847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722016848 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722016849 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722016850 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722016851 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722016852 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722016853 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722016854 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722016855 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722016856 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722016857 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722016858 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722016859 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722016860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722016861 Transposase; Region: HTH_Tnp_1; pfam01527 137722016862 Right handed beta helix region; Region: Beta_helix; pfam13229 137722016863 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 137722016864 DNA-binding site [nucleotide binding]; DNA binding site 137722016865 RNA-binding motif; other site 137722016866 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 137722016867 RNA binding site [nucleotide binding]; other site 137722016868 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 137722016869 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 137722016870 Surface antigen; Region: Bac_surface_Ag; pfam01103 137722016871 CHASE2 domain; Region: CHASE2; pfam05226 137722016872 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 137722016873 cyclase homology domain; Region: CHD; cd07302 137722016874 nucleotidyl binding site; other site 137722016875 metal binding site [ion binding]; metal-binding site 137722016876 dimer interface [polypeptide binding]; other site 137722016877 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722016878 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722016879 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722016880 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722016881 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 137722016882 PhoU domain; Region: PhoU; pfam01895 137722016883 PhoU domain; Region: PhoU; pfam01895 137722016884 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 137722016885 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 137722016886 motif 1; other site 137722016887 dimer interface [polypeptide binding]; other site 137722016888 active site 137722016889 motif 2; other site 137722016890 motif 3; other site 137722016891 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 137722016892 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 137722016893 GDP-binding site [chemical binding]; other site 137722016894 ACT binding site; other site 137722016895 IMP binding site; other site 137722016896 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 137722016897 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 137722016898 putative NAD(P) binding site [chemical binding]; other site 137722016899 putative active site [active] 137722016900 Rrf2 family protein; Region: rrf2_super; TIGR00738 137722016901 Transcriptional regulator; Region: Rrf2; pfam02082 137722016902 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 137722016903 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 137722016904 ParB-like nuclease domain; Region: ParB; smart00470 137722016905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722016906 S-adenosylmethionine binding site [chemical binding]; other site 137722016907 Methyltransferase domain; Region: Methyltransf_24; pfam13578 137722016908 Transcriptional regulators [Transcription]; Region: FadR; COG2186 137722016909 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722016910 DNA-binding site [nucleotide binding]; DNA binding site 137722016911 FCD domain; Region: FCD; pfam07729 137722016912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722016913 putative substrate translocation pore; other site 137722016914 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722016915 malate synthase G; Provisional; Region: PRK02999 137722016916 active site 137722016917 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 137722016918 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 137722016919 Transcriptional regulator; Region: Rrf2; pfam02082 137722016920 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 137722016921 putative ABC transporter; Region: ycf24; CHL00085 137722016922 FeS assembly ATPase SufC; Region: sufC; TIGR01978 137722016923 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 137722016924 Walker A/P-loop; other site 137722016925 ATP binding site [chemical binding]; other site 137722016926 Q-loop/lid; other site 137722016927 ABC transporter signature motif; other site 137722016928 Walker B; other site 137722016929 D-loop; other site 137722016930 H-loop/switch region; other site 137722016931 FeS assembly protein SufD; Region: sufD; TIGR01981 137722016932 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 137722016933 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 137722016934 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 137722016935 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722016936 catalytic residue [active] 137722016937 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 137722016938 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 137722016939 trimerization site [polypeptide binding]; other site 137722016940 active site 137722016941 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 137722016942 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 137722016943 Pirin-related protein [General function prediction only]; Region: COG1741 137722016944 Pirin; Region: Pirin; pfam02678 137722016945 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 137722016946 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 137722016947 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 137722016948 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 137722016949 dimerization interface [polypeptide binding]; other site 137722016950 ligand binding site [chemical binding]; other site 137722016951 Transcriptional regulator [Transcription]; Region: IclR; COG1414 137722016952 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 137722016953 Bacterial transcriptional regulator; Region: IclR; pfam01614 137722016954 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 137722016955 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 137722016956 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 137722016957 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 137722016958 active site 137722016959 intersubunit interface [polypeptide binding]; other site 137722016960 catalytic residue [active] 137722016961 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 137722016962 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 137722016963 substrate binding site [chemical binding]; other site 137722016964 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 137722016965 substrate binding site [chemical binding]; other site 137722016966 ligand binding site [chemical binding]; other site 137722016967 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 137722016968 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 137722016969 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 137722016970 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 137722016971 putative active site [active] 137722016972 Pyruvate formate lyase 1; Region: PFL1; cd01678 137722016973 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 137722016974 coenzyme A binding site [chemical binding]; other site 137722016975 active site 137722016976 catalytic residues [active] 137722016977 glycine loop; other site 137722016978 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 137722016979 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722016980 FeS/SAM binding site; other site 137722016981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 137722016982 Autotransporter beta-domain; Region: Autotransporter; smart00869 137722016983 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722016984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722016985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722016986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722016987 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 137722016988 putative effector binding pocket; other site 137722016989 putative dimerization interface [polypeptide binding]; other site 137722016990 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 137722016991 FAD binding domain; Region: FAD_binding_4; pfam01565 137722016992 Berberine and berberine like; Region: BBE; pfam08031 137722016993 Transcriptional regulators [Transcription]; Region: PurR; COG1609 137722016994 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 137722016995 DNA binding site [nucleotide binding] 137722016996 domain linker motif; other site 137722016997 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 137722016998 putative dimerization interface [polypeptide binding]; other site 137722016999 putative ligand binding site [chemical binding]; other site 137722017000 altronate oxidoreductase; Provisional; Region: PRK03643 137722017001 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 137722017002 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 137722017003 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 137722017004 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 137722017005 dimer interface [polypeptide binding]; other site 137722017006 PYR/PP interface [polypeptide binding]; other site 137722017007 TPP binding site [chemical binding]; other site 137722017008 substrate binding site [chemical binding]; other site 137722017009 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 137722017010 Domain of unknown function; Region: EKR; pfam10371 137722017011 4Fe-4S binding domain; Region: Fer4; pfam00037 137722017012 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 137722017013 TPP-binding site [chemical binding]; other site 137722017014 dimer interface [polypeptide binding]; other site 137722017015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722017016 D-galactonate transporter; Region: 2A0114; TIGR00893 137722017017 putative substrate translocation pore; other site 137722017018 HAMP domain; Region: HAMP; pfam00672 137722017019 dimerization interface [polypeptide binding]; other site 137722017020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722017021 dimer interface [polypeptide binding]; other site 137722017022 putative CheW interface [polypeptide binding]; other site 137722017023 MarR family; Region: MarR_2; cl17246 137722017024 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 137722017025 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 137722017026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722017027 Walker A/P-loop; other site 137722017028 ATP binding site [chemical binding]; other site 137722017029 Q-loop/lid; other site 137722017030 ABC transporter signature motif; other site 137722017031 Walker B; other site 137722017032 D-loop; other site 137722017033 H-loop/switch region; other site 137722017034 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 137722017035 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 137722017036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722017037 Walker A/P-loop; other site 137722017038 ATP binding site [chemical binding]; other site 137722017039 Q-loop/lid; other site 137722017040 ABC transporter signature motif; other site 137722017041 Walker B; other site 137722017042 D-loop; other site 137722017043 H-loop/switch region; other site 137722017044 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 137722017045 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 137722017046 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722017047 DNA polymerase I; Provisional; Region: PRK05755 137722017048 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 137722017049 active site 137722017050 metal binding site 1 [ion binding]; metal-binding site 137722017051 putative 5' ssDNA interaction site; other site 137722017052 metal binding site 3; metal-binding site 137722017053 metal binding site 2 [ion binding]; metal-binding site 137722017054 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 137722017055 putative DNA binding site [nucleotide binding]; other site 137722017056 putative metal binding site [ion binding]; other site 137722017057 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 137722017058 active site 137722017059 catalytic site [active] 137722017060 substrate binding site [chemical binding]; other site 137722017061 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 137722017062 active site 137722017063 DNA binding site [nucleotide binding] 137722017064 catalytic site [active] 137722017065 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722017066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722017067 active site 137722017068 phosphorylation site [posttranslational modification] 137722017069 intermolecular recognition site; other site 137722017070 dimerization interface [polypeptide binding]; other site 137722017071 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722017072 DNA binding site [nucleotide binding] 137722017073 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722017074 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722017075 substrate binding pocket [chemical binding]; other site 137722017076 membrane-bound complex binding site; other site 137722017077 hinge residues; other site 137722017078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722017079 dimerization interface [polypeptide binding]; other site 137722017080 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 137722017081 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 137722017082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722017083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722017084 dimer interface [polypeptide binding]; other site 137722017085 phosphorylation site [posttranslational modification] 137722017086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722017087 ATP binding site [chemical binding]; other site 137722017088 Mg2+ binding site [ion binding]; other site 137722017089 G-X-G motif; other site 137722017090 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722017091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722017092 metal binding site [ion binding]; metal-binding site 137722017093 active site 137722017094 I-site; other site 137722017095 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 137722017096 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 137722017097 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 137722017098 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 137722017099 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 137722017100 XdhC Rossmann domain; Region: XdhC_C; pfam13478 137722017101 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 137722017102 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 137722017103 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 137722017104 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 137722017105 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 137722017106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 137722017107 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 137722017108 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722017109 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722017110 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722017111 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722017112 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 137722017113 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 137722017114 active site 137722017115 substrate binding site [chemical binding]; other site 137722017116 coenzyme B12 binding site [chemical binding]; other site 137722017117 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 137722017118 B12 binding site [chemical binding]; other site 137722017119 cobalt ligand [ion binding]; other site 137722017120 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 137722017121 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 137722017122 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 137722017123 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 137722017124 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 137722017125 carboxyltransferase (CT) interaction site; other site 137722017126 biotinylation site [posttranslational modification]; other site 137722017127 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 137722017128 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 137722017129 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 137722017130 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722017131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722017132 non-specific DNA binding site [nucleotide binding]; other site 137722017133 salt bridge; other site 137722017134 sequence-specific DNA binding site [nucleotide binding]; other site 137722017135 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 137722017136 Domain of unknown function (DUF955); Region: DUF955; pfam06114 137722017137 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 137722017138 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722017139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722017140 active site 137722017141 phosphorylation site [posttranslational modification] 137722017142 intermolecular recognition site; other site 137722017143 dimerization interface [polypeptide binding]; other site 137722017144 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 137722017145 active site 137722017146 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 137722017147 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 137722017148 Autotransporter beta-domain; Region: Autotransporter; pfam03797 137722017149 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 137722017150 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 137722017151 cytochrome b; Provisional; Region: CYTB; MTH00191 137722017152 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 137722017153 interchain domain interface [polypeptide binding]; other site 137722017154 intrachain domain interface; other site 137722017155 heme bH binding site [chemical binding]; other site 137722017156 Qi binding site; other site 137722017157 heme bL binding site [chemical binding]; other site 137722017158 Qo binding site; other site 137722017159 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 137722017160 interchain domain interface [polypeptide binding]; other site 137722017161 intrachain domain interface; other site 137722017162 Qi binding site; other site 137722017163 Qo binding site; other site 137722017164 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 137722017165 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 137722017166 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 137722017167 [2Fe-2S] cluster binding site [ion binding]; other site 137722017168 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 137722017169 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 137722017170 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 137722017171 HAMP domain; Region: HAMP; pfam00672 137722017172 dimerization interface [polypeptide binding]; other site 137722017173 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 137722017174 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722017175 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722017176 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722017177 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722017178 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 137722017179 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 137722017180 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 137722017181 putative dimer interface [polypeptide binding]; other site 137722017182 N-terminal domain interface [polypeptide binding]; other site 137722017183 putative substrate binding pocket (H-site) [chemical binding]; other site 137722017184 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 137722017185 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 137722017186 LysR family transcriptional regulator; Provisional; Region: PRK14997 137722017187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722017188 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 137722017189 putative effector binding pocket; other site 137722017190 dimerization interface [polypeptide binding]; other site 137722017191 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 137722017192 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 137722017193 homodimer interface [polypeptide binding]; other site 137722017194 substrate-cofactor binding pocket; other site 137722017195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722017196 catalytic residue [active] 137722017197 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 137722017198 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 137722017199 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 137722017200 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 137722017201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722017202 NAD(P) binding site [chemical binding]; other site 137722017203 active site 137722017204 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 137722017205 Clp amino terminal domain; Region: Clp_N; pfam02861 137722017206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722017207 Walker A motif; other site 137722017208 ATP binding site [chemical binding]; other site 137722017209 Walker B motif; other site 137722017210 arginine finger; other site 137722017211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722017212 Walker A motif; other site 137722017213 ATP binding site [chemical binding]; other site 137722017214 Walker B motif; other site 137722017215 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 137722017216 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 137722017217 active site clefts [active] 137722017218 zinc binding site [ion binding]; other site 137722017219 dimer interface [polypeptide binding]; other site 137722017220 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 137722017221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722017222 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 137722017223 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 137722017224 putative dimerization interface [polypeptide binding]; other site 137722017225 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 137722017226 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722017227 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722017228 ligand binding site [chemical binding]; other site 137722017229 flexible hinge region; other site 137722017230 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 137722017231 EamA-like transporter family; Region: EamA; pfam00892 137722017232 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 137722017233 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 137722017234 choline dehydrogenase; Validated; Region: PRK02106 137722017235 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 137722017236 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 137722017237 dimer interface [polypeptide binding]; other site 137722017238 PYR/PP interface [polypeptide binding]; other site 137722017239 TPP binding site [chemical binding]; other site 137722017240 substrate binding site [chemical binding]; other site 137722017241 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 137722017242 TPP-binding site [chemical binding]; other site 137722017243 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 137722017244 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 137722017245 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722017246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722017247 Walker A motif; other site 137722017248 ATP binding site [chemical binding]; other site 137722017249 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722017250 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722017251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722017252 Integrase core domain; Region: rve; pfam00665 137722017253 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 137722017254 TPR repeat; Region: TPR_11; pfam13414 137722017255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722017256 binding surface 137722017257 TPR motif; other site 137722017258 TPR repeat; Region: TPR_11; pfam13414 137722017259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722017260 binding surface 137722017261 TPR motif; other site 137722017262 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 137722017263 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 137722017264 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 137722017265 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 137722017266 DXD motif; other site 137722017267 PilZ domain; Region: PilZ; pfam07238 137722017268 Predicted permeases [General function prediction only]; Region: COG0679 137722017269 OsmC-like protein; Region: OsmC; cl00767 137722017270 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 137722017271 putative FMN binding site [chemical binding]; other site 137722017272 Response regulator receiver domain; Region: Response_reg; pfam00072 137722017273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722017274 active site 137722017275 phosphorylation site [posttranslational modification] 137722017276 intermolecular recognition site; other site 137722017277 dimerization interface [polypeptide binding]; other site 137722017278 CHASE3 domain; Region: CHASE3; pfam05227 137722017279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 137722017280 Histidine kinase; Region: HisKA_2; pfam07568 137722017281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722017282 ATP binding site [chemical binding]; other site 137722017283 Mg2+ binding site [ion binding]; other site 137722017284 G-X-G motif; other site 137722017285 PAS domain; Region: PAS_9; pfam13426 137722017286 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722017287 heme pocket [chemical binding]; other site 137722017288 putative active site [active] 137722017289 PAS fold; Region: PAS; pfam00989 137722017290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722017291 putative active site [active] 137722017292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722017293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 137722017294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722017295 ATP binding site [chemical binding]; other site 137722017296 G-X-G motif; other site 137722017297 Response regulator receiver domain; Region: Response_reg; pfam00072 137722017298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722017299 active site 137722017300 phosphorylation site [posttranslational modification] 137722017301 intermolecular recognition site; other site 137722017302 dimerization interface [polypeptide binding]; other site 137722017303 CheB methylesterase; Region: CheB_methylest; pfam01339 137722017304 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 137722017305 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 137722017306 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 137722017307 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 137722017308 PAS domain; Region: PAS_10; pfam13596 137722017309 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722017310 putative active site [active] 137722017311 heme pocket [chemical binding]; other site 137722017312 PAS fold; Region: PAS_4; pfam08448 137722017313 NAD synthetase; Reviewed; Region: nadE; PRK02628 137722017314 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 137722017315 multimer interface [polypeptide binding]; other site 137722017316 active site 137722017317 catalytic triad [active] 137722017318 protein interface 1 [polypeptide binding]; other site 137722017319 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 137722017320 homodimer interface [polypeptide binding]; other site 137722017321 NAD binding pocket [chemical binding]; other site 137722017322 ATP binding pocket [chemical binding]; other site 137722017323 Mg binding site [ion binding]; other site 137722017324 active-site loop [active] 137722017325 Flagellar protein FlaF; Region: FlaF; pfam07309 137722017326 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 137722017327 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 137722017328 putative active site [active] 137722017329 Predicted permeases [General function prediction only]; Region: COG0795 137722017330 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 137722017331 TPR repeat; Region: TPR_11; pfam13414 137722017332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722017333 TPR motif; other site 137722017334 binding surface 137722017335 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 137722017336 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 137722017337 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 137722017338 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 137722017339 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722017340 catalytic residue [active] 137722017341 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722017342 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 137722017343 P-loop; other site 137722017344 Magnesium ion binding site [ion binding]; other site 137722017345 Initiator Replication protein; Region: Rep_3; pfam01051 137722017346 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 137722017347 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722017348 MarR family; Region: MarR_2; pfam12802 137722017349 Predicted membrane protein [Function unknown]; Region: COG3766 137722017350 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 137722017351 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 137722017352 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 137722017353 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 137722017354 putative acyl-acceptor binding pocket; other site 137722017355 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 137722017356 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 137722017357 Walker A/P-loop; other site 137722017358 ATP binding site [chemical binding]; other site 137722017359 Q-loop/lid; other site 137722017360 ABC transporter signature motif; other site 137722017361 Walker B; other site 137722017362 D-loop; other site 137722017363 H-loop/switch region; other site 137722017364 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 137722017365 Uncharacterized conserved protein [Function unknown]; Region: COG1434 137722017366 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 137722017367 putative active site [active] 137722017368 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 137722017369 metal-binding site [ion binding] 137722017370 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 137722017371 Coenzyme A transferase; Region: CoA_trans; cl17247 137722017372 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 137722017373 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 137722017374 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 137722017375 NAD binding site [chemical binding]; other site 137722017376 homotetramer interface [polypeptide binding]; other site 137722017377 homodimer interface [polypeptide binding]; other site 137722017378 substrate binding site [chemical binding]; other site 137722017379 active site 137722017380 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722017381 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722017382 ligand binding site [chemical binding]; other site 137722017383 flexible hinge region; other site 137722017384 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 137722017385 non-specific DNA interactions [nucleotide binding]; other site 137722017386 DNA binding site [nucleotide binding] 137722017387 sequence specific DNA binding site [nucleotide binding]; other site 137722017388 putative cAMP binding site [chemical binding]; other site 137722017389 TfuA-like protein; Region: TfuA; pfam07812 137722017390 Uncharacterized conserved protein [Function unknown]; Region: COG1944 137722017391 YcaO-like family; Region: YcaO; pfam02624 137722017392 cyclase homology domain; Region: CHD; cd07302 137722017393 nucleotidyl binding site; other site 137722017394 metal binding site [ion binding]; metal-binding site 137722017395 dimer interface [polypeptide binding]; other site 137722017396 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 137722017397 AAA ATPase domain; Region: AAA_16; pfam13191 137722017398 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 137722017399 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722017400 MarR family; Region: MarR; pfam01047 137722017401 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 137722017402 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722017403 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722017404 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 137722017405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722017406 putative substrate translocation pore; other site 137722017407 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 137722017408 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 137722017409 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 137722017410 putative active site [active] 137722017411 O-Antigen ligase; Region: Wzy_C; pfam04932 137722017412 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 137722017413 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 137722017414 Predicted acetyltransferase [General function prediction only]; Region: COG2388 137722017415 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 137722017416 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 137722017417 active site 137722017418 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 137722017419 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 137722017420 active site 137722017421 tetramer interface; other site 137722017422 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 137722017423 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 137722017424 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 137722017425 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 137722017426 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 137722017427 active site 137722017428 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 137722017429 substrate binding site [chemical binding]; other site 137722017430 metal binding site [ion binding]; metal-binding site 137722017431 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 137722017432 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 137722017433 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 137722017434 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 137722017435 Walker A/P-loop; other site 137722017436 ATP binding site [chemical binding]; other site 137722017437 Q-loop/lid; other site 137722017438 ABC transporter signature motif; other site 137722017439 Walker B; other site 137722017440 D-loop; other site 137722017441 H-loop/switch region; other site 137722017442 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 137722017443 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 137722017444 Walker A/P-loop; other site 137722017445 ATP binding site [chemical binding]; other site 137722017446 Q-loop/lid; other site 137722017447 ABC transporter signature motif; other site 137722017448 Walker B; other site 137722017449 D-loop; other site 137722017450 H-loop/switch region; other site 137722017451 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 137722017452 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 137722017453 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722017454 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722017455 Transcriptional regulators [Transcription]; Region: PurR; COG1609 137722017456 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 137722017457 DNA binding site [nucleotide binding] 137722017458 domain linker motif; other site 137722017459 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 137722017460 putative dimerization interface [polypeptide binding]; other site 137722017461 putative ligand binding site [chemical binding]; other site 137722017462 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 137722017463 AAA domain; Region: AAA_33; pfam13671 137722017464 ATP-binding site [chemical binding]; other site 137722017465 Gluconate-6-phosphate binding site [chemical binding]; other site 137722017466 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 137722017467 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 137722017468 DctM-like transporters; Region: DctM; pfam06808 137722017469 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 137722017470 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 137722017471 Cache domain; Region: Cache_1; pfam02743 137722017472 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722017473 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722017474 dimer interface [polypeptide binding]; other site 137722017475 putative CheW interface [polypeptide binding]; other site 137722017476 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 137722017477 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 137722017478 heterodimer interface [polypeptide binding]; other site 137722017479 active site 137722017480 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 137722017481 heterodimer interface [polypeptide binding]; other site 137722017482 multimer interface [polypeptide binding]; other site 137722017483 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 137722017484 active site 137722017485 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 137722017486 active site 137722017487 tetramer interface [polypeptide binding]; other site 137722017488 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 137722017489 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 137722017490 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 137722017491 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 137722017492 dimer interface [polypeptide binding]; other site 137722017493 active site 137722017494 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 137722017495 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 137722017496 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 137722017497 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 137722017498 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722017499 TM-ABC transporter signature motif; other site 137722017500 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 137722017501 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722017502 TM-ABC transporter signature motif; other site 137722017503 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722017504 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722017505 Walker A/P-loop; other site 137722017506 ATP binding site [chemical binding]; other site 137722017507 Q-loop/lid; other site 137722017508 ABC transporter signature motif; other site 137722017509 Walker B; other site 137722017510 D-loop; other site 137722017511 H-loop/switch region; other site 137722017512 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722017513 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722017514 Walker A/P-loop; other site 137722017515 ATP binding site [chemical binding]; other site 137722017516 Q-loop/lid; other site 137722017517 ABC transporter signature motif; other site 137722017518 Walker B; other site 137722017519 D-loop; other site 137722017520 H-loop/switch region; other site 137722017521 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 137722017522 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722017523 substrate binding pocket [chemical binding]; other site 137722017524 membrane-bound complex binding site; other site 137722017525 hinge residues; other site 137722017526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722017527 dimerization interface [polypeptide binding]; other site 137722017528 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722017529 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722017530 dimer interface [polypeptide binding]; other site 137722017531 putative CheW interface [polypeptide binding]; other site 137722017532 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 137722017533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722017534 active site 137722017535 phosphorylation site [posttranslational modification] 137722017536 intermolecular recognition site; other site 137722017537 dimerization interface [polypeptide binding]; other site 137722017538 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722017539 DNA binding site [nucleotide binding] 137722017540 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 137722017541 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 137722017542 Walker A/P-loop; other site 137722017543 ATP binding site [chemical binding]; other site 137722017544 Q-loop/lid; other site 137722017545 ABC transporter signature motif; other site 137722017546 Walker B; other site 137722017547 D-loop; other site 137722017548 H-loop/switch region; other site 137722017549 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 137722017550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722017551 dimer interface [polypeptide binding]; other site 137722017552 conserved gate region; other site 137722017553 putative PBP binding loops; other site 137722017554 ABC-ATPase subunit interface; other site 137722017555 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 137722017556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 137722017557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722017558 putative PBP binding loops; other site 137722017559 dimer interface [polypeptide binding]; other site 137722017560 ABC-ATPase subunit interface; other site 137722017561 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 137722017562 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722017563 substrate binding pocket [chemical binding]; other site 137722017564 membrane-bound complex binding site; other site 137722017565 hinge residues; other site 137722017566 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 137722017567 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 137722017568 HAMP domain; Region: HAMP; pfam00672 137722017569 dimerization interface [polypeptide binding]; other site 137722017570 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722017571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722017572 dimer interface [polypeptide binding]; other site 137722017573 putative CheW interface [polypeptide binding]; other site 137722017574 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 137722017575 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 137722017576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722017577 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 137722017578 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 137722017579 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 137722017580 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 137722017581 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 137722017582 Nitrogen regulatory protein P-II; Region: P-II; smart00938 137722017583 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 137722017584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722017585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722017586 homodimer interface [polypeptide binding]; other site 137722017587 catalytic residue [active] 137722017588 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 137722017589 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 137722017590 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 137722017591 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 137722017592 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 137722017593 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 137722017594 putative PBP binding regions; other site 137722017595 ABC-ATPase subunit interface; other site 137722017596 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 137722017597 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 137722017598 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 137722017599 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 137722017600 metal binding site [ion binding]; metal-binding site 137722017601 dihydrodipicolinate reductase; Provisional; Region: PRK00048 137722017602 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 137722017603 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 137722017604 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722017605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722017606 active site 137722017607 phosphorylation site [posttranslational modification] 137722017608 intermolecular recognition site; other site 137722017609 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 137722017610 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 137722017611 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 137722017612 Zn2+ binding site [ion binding]; other site 137722017613 Mg2+ binding site [ion binding]; other site 137722017614 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 137722017615 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 137722017616 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 137722017617 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 137722017618 FAD binding pocket [chemical binding]; other site 137722017619 FAD binding motif [chemical binding]; other site 137722017620 phosphate binding motif [ion binding]; other site 137722017621 beta-alpha-beta structure motif; other site 137722017622 NAD binding pocket [chemical binding]; other site 137722017623 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722017624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722017625 non-specific DNA binding site [nucleotide binding]; other site 137722017626 salt bridge; other site 137722017627 sequence-specific DNA binding site [nucleotide binding]; other site 137722017628 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 137722017629 Domain of unknown function (DUF955); Region: DUF955; pfam06114 137722017630 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 137722017631 isocitrate lyase; Provisional; Region: PRK15063 137722017632 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 137722017633 tetramer interface [polypeptide binding]; other site 137722017634 active site 137722017635 Mg2+/Mn2+ binding site [ion binding]; other site 137722017636 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 137722017637 intracellular protease, PfpI family; Region: PfpI; TIGR01382 137722017638 conserved cys residue [active] 137722017639 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722017640 HAMP domain; Region: HAMP; pfam00672 137722017641 dimerization interface [polypeptide binding]; other site 137722017642 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722017643 dimer interface [polypeptide binding]; other site 137722017644 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722017645 putative CheW interface [polypeptide binding]; other site 137722017646 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 137722017647 prephenate dehydrogenase; Validated; Region: PRK08507 137722017648 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 137722017649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722017650 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 137722017651 dimerization interface [polypeptide binding]; other site 137722017652 peroxiredoxin; Region: AhpC; TIGR03137 137722017653 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 137722017654 dimer interface [polypeptide binding]; other site 137722017655 decamer (pentamer of dimers) interface [polypeptide binding]; other site 137722017656 catalytic triad [active] 137722017657 peroxidatic and resolving cysteines [active] 137722017658 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 137722017659 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 137722017660 catalytic residue [active] 137722017661 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 137722017662 catalytic residues [active] 137722017663 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 137722017664 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 137722017665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722017666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722017667 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 137722017668 putative effector binding pocket; other site 137722017669 putative dimerization interface [polypeptide binding]; other site 137722017670 SnoaL-like domain; Region: SnoaL_2; pfam12680 137722017671 short chain dehydrogenase; Provisional; Region: PRK06523 137722017672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722017673 NAD(P) binding site [chemical binding]; other site 137722017674 active site 137722017675 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 137722017676 putative catalytic site [active] 137722017677 putative metal binding site [ion binding]; other site 137722017678 putative phosphate binding site [ion binding]; other site 137722017679 CheD chemotactic sensory transduction; Region: CheD; cl00810 137722017680 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 137722017681 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 137722017682 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 137722017683 phosphopeptide binding site; other site 137722017684 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 137722017685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722017686 putative substrate translocation pore; other site 137722017687 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 137722017688 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 137722017689 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 137722017690 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 137722017691 Cupin domain; Region: Cupin_2; cl17218 137722017692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722017693 serine acetyltransferase; Provisional; Region: cysE; PRK11132 137722017694 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 137722017695 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 137722017696 trimer interface [polypeptide binding]; other site 137722017697 active site 137722017698 substrate binding site [chemical binding]; other site 137722017699 CoA binding site [chemical binding]; other site 137722017700 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 137722017701 DNA polymerase IV; Provisional; Region: PRK02794 137722017702 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 137722017703 active site 137722017704 DNA binding site [nucleotide binding] 137722017705 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 137722017706 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 137722017707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722017708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722017709 dimer interface [polypeptide binding]; other site 137722017710 phosphorylation site [posttranslational modification] 137722017711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722017712 ATP binding site [chemical binding]; other site 137722017713 Mg2+ binding site [ion binding]; other site 137722017714 G-X-G motif; other site 137722017715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722017716 Response regulator receiver domain; Region: Response_reg; pfam00072 137722017717 active site 137722017718 phosphorylation site [posttranslational modification] 137722017719 intermolecular recognition site; other site 137722017720 dimerization interface [polypeptide binding]; other site 137722017721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722017722 Response regulator receiver domain; Region: Response_reg; pfam00072 137722017723 active site 137722017724 phosphorylation site [posttranslational modification] 137722017725 intermolecular recognition site; other site 137722017726 dimerization interface [polypeptide binding]; other site 137722017727 tellurium resistance terB-like protein; Region: terB_like; cd07177 137722017728 metal binding site [ion binding]; metal-binding site 137722017729 diaminopimelate decarboxylase; Region: lysA; TIGR01048 137722017730 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 137722017731 active site 137722017732 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 137722017733 substrate binding site [chemical binding]; other site 137722017734 catalytic residues [active] 137722017735 dimer interface [polypeptide binding]; other site 137722017736 argininosuccinate lyase; Provisional; Region: PRK00855 137722017737 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 137722017738 active sites [active] 137722017739 tetramer interface [polypeptide binding]; other site 137722017740 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 137722017741 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 137722017742 catalytic residues [active] 137722017743 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722017744 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722017745 ligand binding site [chemical binding]; other site 137722017746 flexible hinge region; other site 137722017747 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722017748 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722017749 ligand binding site [chemical binding]; other site 137722017750 flexible hinge region; other site 137722017751 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722017752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 137722017753 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722017754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722017755 dimer interface [polypeptide binding]; other site 137722017756 putative CheW interface [polypeptide binding]; other site 137722017757 tartronate semialdehyde reductase; Provisional; Region: PRK15059 137722017758 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 137722017759 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 137722017760 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 137722017761 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 137722017762 active site 137722017763 FMN binding site [chemical binding]; other site 137722017764 2,4-decadienoyl-CoA binding site; other site 137722017765 catalytic residue [active] 137722017766 4Fe-4S cluster binding site [ion binding]; other site 137722017767 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 137722017768 HipA N-terminal domain; Region: Couple_hipA; pfam13657 137722017769 HipA-like N-terminal domain; Region: HipA_N; pfam07805 137722017770 HipA-like C-terminal domain; Region: HipA_C; pfam07804 137722017771 Uncharacterized conserved protein [Function unknown]; Region: COG1479 137722017772 Protein of unknown function DUF262; Region: DUF262; pfam03235 137722017773 Uncharacterized conserved protein [Function unknown]; Region: COG3472 137722017774 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722017775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722017776 DNA-binding site [nucleotide binding]; DNA binding site 137722017777 FCD domain; Region: FCD; pfam07729 137722017778 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 137722017779 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 137722017780 phenylhydantoinase; Validated; Region: PRK08323 137722017781 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 137722017782 tetramer interface [polypeptide binding]; other site 137722017783 active site 137722017784 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 137722017785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722017786 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 137722017787 allantoate amidohydrolase; Reviewed; Region: PRK12893 137722017788 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 137722017789 active site 137722017790 metal binding site [ion binding]; metal-binding site 137722017791 dimer interface [polypeptide binding]; other site 137722017792 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 137722017793 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 137722017794 homodimer interface [polypeptide binding]; other site 137722017795 active site 137722017796 FMN binding site [chemical binding]; other site 137722017797 substrate binding site [chemical binding]; other site 137722017798 4Fe-4S binding domain; Region: Fer4_6; pfam12837 137722017799 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 137722017800 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 137722017801 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 137722017802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 137722017803 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 137722017804 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 137722017805 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 137722017806 DNA binding site [nucleotide binding] 137722017807 active site 137722017808 oxidoreductase; Provisional; Region: PRK12742 137722017809 classical (c) SDRs; Region: SDR_c; cd05233 137722017810 NAD(P) binding site [chemical binding]; other site 137722017811 active site 137722017812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722017813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722017814 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 137722017815 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 137722017816 substrate binding site [chemical binding]; other site 137722017817 ATP binding site [chemical binding]; other site 137722017818 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 137722017819 EamA-like transporter family; Region: EamA; pfam00892 137722017820 galactarate dehydratase; Region: galactar-dH20; TIGR03248 137722017821 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 137722017822 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 137722017823 glucuronate isomerase; Reviewed; Region: PRK02925 137722017824 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 137722017825 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722017826 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722017827 DNA-binding site [nucleotide binding]; DNA binding site 137722017828 FCD domain; Region: FCD; pfam07729 137722017829 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 137722017830 active site 1 [active] 137722017831 dimer interface [polypeptide binding]; other site 137722017832 hexamer interface [polypeptide binding]; other site 137722017833 active site 2 [active] 137722017834 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 137722017835 SnoaL-like domain; Region: SnoaL_3; pfam13474 137722017836 glutathionine S-transferase; Provisional; Region: PRK10542 137722017837 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 137722017838 C-terminal domain interface [polypeptide binding]; other site 137722017839 GSH binding site (G-site) [chemical binding]; other site 137722017840 dimer interface [polypeptide binding]; other site 137722017841 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 137722017842 N-terminal domain interface [polypeptide binding]; other site 137722017843 dimer interface [polypeptide binding]; other site 137722017844 substrate binding pocket (H-site) [chemical binding]; other site 137722017845 Predicted transcriptional regulators [Transcription]; Region: COG1733 137722017846 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 137722017847 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 137722017848 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 137722017849 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 137722017850 NADP binding site [chemical binding]; other site 137722017851 homodimer interface [polypeptide binding]; other site 137722017852 active site 137722017853 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 137722017854 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 137722017855 active site 137722017856 dimer interfaces [polypeptide binding]; other site 137722017857 catalytic residues [active] 137722017858 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722017859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722017860 DNA-binding site [nucleotide binding]; DNA binding site 137722017861 FCD domain; Region: FCD; pfam07729 137722017862 NMT1/THI5 like; Region: NMT1; pfam09084 137722017863 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722017864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722017865 dimer interface [polypeptide binding]; other site 137722017866 conserved gate region; other site 137722017867 putative PBP binding loops; other site 137722017868 ABC-ATPase subunit interface; other site 137722017869 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722017870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722017871 dimer interface [polypeptide binding]; other site 137722017872 conserved gate region; other site 137722017873 ABC-ATPase subunit interface; other site 137722017874 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722017875 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722017876 Walker A/P-loop; other site 137722017877 ATP binding site [chemical binding]; other site 137722017878 Q-loop/lid; other site 137722017879 ABC transporter signature motif; other site 137722017880 Walker B; other site 137722017881 D-loop; other site 137722017882 H-loop/switch region; other site 137722017883 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 137722017884 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722017885 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 137722017886 acyl-activating enzyme (AAE) consensus motif; other site 137722017887 AMP binding site [chemical binding]; other site 137722017888 active site 137722017889 CoA binding site [chemical binding]; other site 137722017890 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 137722017891 CoenzymeA binding site [chemical binding]; other site 137722017892 subunit interaction site [polypeptide binding]; other site 137722017893 PHB binding site; other site 137722017894 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 137722017895 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 137722017896 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722017897 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722017898 enoyl-CoA hydratase; Provisional; Region: PRK08140 137722017899 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 137722017900 substrate binding site [chemical binding]; other site 137722017901 oxyanion hole (OAH) forming residues; other site 137722017902 trimer interface [polypeptide binding]; other site 137722017903 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 137722017904 Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Region: ALDH_PAD-PaaZ; cd07127 137722017905 NADP binding site [chemical binding]; other site 137722017906 catalytic residues [active] 137722017907 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 137722017908 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 137722017909 FAD binding pocket [chemical binding]; other site 137722017910 FAD binding motif [chemical binding]; other site 137722017911 phosphate binding motif [ion binding]; other site 137722017912 beta-alpha-beta structure motif; other site 137722017913 NAD(p) ribose binding residues [chemical binding]; other site 137722017914 NAD binding pocket [chemical binding]; other site 137722017915 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 137722017916 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722017917 catalytic loop [active] 137722017918 iron binding site [ion binding]; other site 137722017919 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 137722017920 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 137722017921 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 137722017922 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 137722017923 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 137722017924 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 137722017925 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722017926 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722017927 ligand binding site [chemical binding]; other site 137722017928 flexible hinge region; other site 137722017929 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 137722017930 putative switch regulator; other site 137722017931 non-specific DNA interactions [nucleotide binding]; other site 137722017932 DNA binding site [nucleotide binding] 137722017933 sequence specific DNA binding site [nucleotide binding]; other site 137722017934 putative cAMP binding site [chemical binding]; other site 137722017935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722017936 dimerization interface [polypeptide binding]; other site 137722017937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722017938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722017939 dimer interface [polypeptide binding]; other site 137722017940 phosphorylation site [posttranslational modification] 137722017941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722017942 ATP binding site [chemical binding]; other site 137722017943 Mg2+ binding site [ion binding]; other site 137722017944 G-X-G motif; other site 137722017945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722017946 Response regulator receiver domain; Region: Response_reg; pfam00072 137722017947 active site 137722017948 phosphorylation site [posttranslational modification] 137722017949 intermolecular recognition site; other site 137722017950 dimerization interface [polypeptide binding]; other site 137722017951 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 137722017952 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 137722017953 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 137722017954 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 137722017955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722017956 FeS/SAM binding site; other site 137722017957 Transcriptional regulators [Transcription]; Region: MarR; COG1846 137722017958 MarR family; Region: MarR_2; pfam12802 137722017959 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 137722017960 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 137722017961 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 137722017962 putative active site [active] 137722017963 putative PHP Thumb interface [polypeptide binding]; other site 137722017964 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 137722017965 generic binding surface II; other site 137722017966 generic binding surface I; other site 137722017967 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 137722017968 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 137722017969 EamA-like transporter family; Region: EamA; pfam00892 137722017970 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 137722017971 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 137722017972 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 137722017973 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 137722017974 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 137722017975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722017976 active site 137722017977 phosphorylation site [posttranslational modification] 137722017978 intermolecular recognition site; other site 137722017979 dimerization interface [polypeptide binding]; other site 137722017980 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 137722017981 Zn2+ binding site [ion binding]; other site 137722017982 Mg2+ binding site [ion binding]; other site 137722017983 Response regulator receiver domain; Region: Response_reg; pfam00072 137722017984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722017985 active site 137722017986 phosphorylation site [posttranslational modification] 137722017987 intermolecular recognition site; other site 137722017988 dimerization interface [polypeptide binding]; other site 137722017989 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722017990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722017991 active site 137722017992 phosphorylation site [posttranslational modification] 137722017993 intermolecular recognition site; other site 137722017994 dimerization interface [polypeptide binding]; other site 137722017995 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722017996 DNA binding residues [nucleotide binding] 137722017997 dimerization interface [polypeptide binding]; other site 137722017998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722017999 dimer interface [polypeptide binding]; other site 137722018000 phosphorylation site [posttranslational modification] 137722018001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018002 active site 137722018003 phosphorylation site [posttranslational modification] 137722018004 intermolecular recognition site; other site 137722018005 PAS domain S-box; Region: sensory_box; TIGR00229 137722018006 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722018007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722018008 putative active site [active] 137722018009 heme pocket [chemical binding]; other site 137722018010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722018011 dimer interface [polypeptide binding]; other site 137722018012 phosphorylation site [posttranslational modification] 137722018013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722018014 ATP binding site [chemical binding]; other site 137722018015 Mg2+ binding site [ion binding]; other site 137722018016 G-X-G motif; other site 137722018017 Response regulator receiver domain; Region: Response_reg; pfam00072 137722018018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018019 active site 137722018020 phosphorylation site [posttranslational modification] 137722018021 intermolecular recognition site; other site 137722018022 dimerization interface [polypeptide binding]; other site 137722018023 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 137722018024 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 137722018025 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 137722018026 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722018027 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722018028 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722018029 DNA binding residues [nucleotide binding] 137722018030 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 137722018031 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 137722018032 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 137722018033 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 137722018034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722018035 S-adenosylmethionine binding site [chemical binding]; other site 137722018036 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 137722018037 SnoaL-like domain; Region: SnoaL_2; pfam12680 137722018038 short chain dehydrogenase; Provisional; Region: PRK06101 137722018039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722018040 NAD(P) binding site [chemical binding]; other site 137722018041 active site 137722018042 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 137722018043 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 137722018044 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 137722018045 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 137722018046 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 137722018047 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 137722018048 active site 137722018049 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 137722018050 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 137722018051 dimerization interface [polypeptide binding]; other site 137722018052 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 137722018053 NAD binding site [chemical binding]; other site 137722018054 ligand binding site [chemical binding]; other site 137722018055 catalytic site [active] 137722018056 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 137722018057 ATP binding site [chemical binding]; other site 137722018058 active site 137722018059 substrate binding site [chemical binding]; other site 137722018060 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 137722018061 C-terminal peptidase (prc); Region: prc; TIGR00225 137722018062 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 137722018063 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 137722018064 protein binding site [polypeptide binding]; other site 137722018065 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 137722018066 Catalytic dyad [active] 137722018067 Bacterial sugar transferase; Region: Bac_transf; pfam02397 137722018068 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 137722018069 dimerization interface [polypeptide binding]; other site 137722018070 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 137722018071 ATP binding site [chemical binding]; other site 137722018072 HupF/HypC family; Region: HupF_HypC; pfam01455 137722018073 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 137722018074 G1 box; other site 137722018075 GTP/Mg2+ binding site [chemical binding]; other site 137722018076 G2 box; other site 137722018077 Switch I region; other site 137722018078 Switch II region; other site 137722018079 G4 box; other site 137722018080 G5 box; other site 137722018081 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 137722018082 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 137722018083 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 137722018084 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 137722018085 HutD; Region: HutD; pfam05962 137722018086 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 137722018087 beta-galactosidase; Region: BGL; TIGR03356 137722018088 xanthine permease; Region: pbuX; TIGR03173 137722018089 aromatic amino acid exporter; Provisional; Region: PRK11689 137722018090 biofilm formation regulator HmsP; Provisional; Region: PRK11829 137722018091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722018092 metal binding site [ion binding]; metal-binding site 137722018093 active site 137722018094 I-site; other site 137722018095 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722018096 LysE type translocator; Region: LysE; cl00565 137722018097 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 137722018098 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 137722018099 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 137722018100 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 137722018101 ethanolamine permease; Region: 2A0305; TIGR00908 137722018102 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 137722018103 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 137722018104 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 137722018105 putative catalytic site [active] 137722018106 putative metal binding site [ion binding]; other site 137722018107 putative phosphate binding site [ion binding]; other site 137722018108 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 137722018109 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 137722018110 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 137722018111 putative active site [active] 137722018112 putative active site [active] 137722018113 catalytic site [active] 137722018114 catalytic site [active] 137722018115 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 137722018116 putative active site [active] 137722018117 catalytic site [active] 137722018118 Uncharacterized conserved protein [Function unknown]; Region: COG0398 137722018119 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 137722018120 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 137722018121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722018122 Walker A/P-loop; other site 137722018123 ATP binding site [chemical binding]; other site 137722018124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 137722018125 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722018126 Walker A/P-loop; other site 137722018127 ATP binding site [chemical binding]; other site 137722018128 Q-loop/lid; other site 137722018129 ABC transporter signature motif; other site 137722018130 Walker B; other site 137722018131 D-loop; other site 137722018132 H-loop/switch region; other site 137722018133 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722018134 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722018135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722018136 dimer interface [polypeptide binding]; other site 137722018137 phosphorylation site [posttranslational modification] 137722018138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722018139 ATP binding site [chemical binding]; other site 137722018140 Mg2+ binding site [ion binding]; other site 137722018141 G-X-G motif; other site 137722018142 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 137722018143 DNA-binding site [nucleotide binding]; DNA binding site 137722018144 RNA-binding motif; other site 137722018145 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 137722018146 DNA-binding site [nucleotide binding]; DNA binding site 137722018147 RNA-binding motif; other site 137722018148 hypothetical protein; Provisional; Region: PRK00183 137722018149 SEC-C motif; Region: SEC-C; pfam02810 137722018150 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 137722018151 RNA/DNA hybrid binding site [nucleotide binding]; other site 137722018152 active site 137722018153 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 137722018154 DNA methylase; Region: N6_N4_Mtase; pfam01555 137722018155 Dihydroneopterin aldolase; Region: FolB; smart00905 137722018156 active site 137722018157 ornithine cyclodeaminase; Validated; Region: PRK07340 137722018158 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 137722018159 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 137722018160 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 137722018161 putative NAD(P) binding site [chemical binding]; other site 137722018162 active site 137722018163 Phytochelatin synthase; Region: Phytochelatin; pfam05023 137722018164 Right handed beta helix region; Region: Beta_helix; pfam13229 137722018165 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722018166 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722018167 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 137722018168 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 137722018169 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 137722018170 dimer interface [polypeptide binding]; other site 137722018171 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 137722018172 active site 137722018173 Fe binding site [ion binding]; other site 137722018174 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722018175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722018176 putative DNA binding site [nucleotide binding]; other site 137722018177 putative Zn2+ binding site [ion binding]; other site 137722018178 AsnC family; Region: AsnC_trans_reg; pfam01037 137722018179 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 137722018180 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722018181 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 137722018182 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722018183 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722018184 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 137722018185 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722018186 putative glycosyl transferase; Provisional; Region: PRK10307 137722018187 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 137722018188 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 137722018189 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 137722018190 NADP binding site [chemical binding]; other site 137722018191 active site 137722018192 putative substrate binding site [chemical binding]; other site 137722018193 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 137722018194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722018195 NAD(P) binding site [chemical binding]; other site 137722018196 active site 137722018197 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 137722018198 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 137722018199 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 137722018200 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 137722018201 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 137722018202 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 137722018203 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 137722018204 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 137722018205 Chain length determinant protein; Region: Wzz; pfam02706 137722018206 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 137722018207 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 137722018208 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 137722018209 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 137722018210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018211 active site 137722018212 phosphorylation site [posttranslational modification] 137722018213 intermolecular recognition site; other site 137722018214 dimerization interface [polypeptide binding]; other site 137722018215 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 137722018216 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722018217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722018218 ATP binding site [chemical binding]; other site 137722018219 Mg2+ binding site [ion binding]; other site 137722018220 G-X-G motif; other site 137722018221 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 137722018222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722018223 Walker A/P-loop; other site 137722018224 ATP binding site [chemical binding]; other site 137722018225 Q-loop/lid; other site 137722018226 ABC transporter signature motif; other site 137722018227 Walker B; other site 137722018228 D-loop; other site 137722018229 H-loop/switch region; other site 137722018230 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 137722018231 ABC-2 type transporter; Region: ABC2_membrane; cl17235 137722018232 Putative transcription activator [Transcription]; Region: TenA; COG0819 137722018233 Helix-turn-helix domain; Region: HTH_17; pfam12728 137722018234 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 137722018235 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 137722018236 dimer interface [polypeptide binding]; other site 137722018237 active site 137722018238 oxalacetate/citrate binding site [chemical binding]; other site 137722018239 citrylCoA binding site [chemical binding]; other site 137722018240 coenzyme A binding site [chemical binding]; other site 137722018241 catalytic triad [active] 137722018242 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 137722018243 CoA-transferase family III; Region: CoA_transf_3; pfam02515 137722018244 Predicted membrane protein [Function unknown]; Region: COG1971 137722018245 Domain of unknown function DUF; Region: DUF204; pfam02659 137722018246 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722018247 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722018248 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722018249 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722018250 guanine deaminase; Provisional; Region: PRK09228 137722018251 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 137722018252 active site 137722018253 Predicted membrane protein [Function unknown]; Region: COG3748 137722018254 Protein of unknown function (DUF989); Region: DUF989; pfam06181 137722018255 Cytochrome c; Region: Cytochrom_C; pfam00034 137722018256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722018257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722018258 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 137722018259 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722018260 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722018261 multidrug efflux protein; Reviewed; Region: PRK09579 137722018262 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 137722018263 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722018264 PAS domain; Region: PAS; smart00091 137722018265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722018266 dimer interface [polypeptide binding]; other site 137722018267 phosphorylation site [posttranslational modification] 137722018268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722018269 ATP binding site [chemical binding]; other site 137722018270 Mg2+ binding site [ion binding]; other site 137722018271 G-X-G motif; other site 137722018272 Response regulator receiver domain; Region: Response_reg; pfam00072 137722018273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018274 active site 137722018275 phosphorylation site [posttranslational modification] 137722018276 intermolecular recognition site; other site 137722018277 dimerization interface [polypeptide binding]; other site 137722018278 Response regulator receiver domain; Region: Response_reg; pfam00072 137722018279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018280 active site 137722018281 phosphorylation site [posttranslational modification] 137722018282 intermolecular recognition site; other site 137722018283 dimerization interface [polypeptide binding]; other site 137722018284 NnrS protein; Region: NnrS; pfam05940 137722018285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 137722018286 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 137722018287 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 137722018288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722018289 Coenzyme A binding pocket [chemical binding]; other site 137722018290 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722018291 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722018292 putative DNA binding site [nucleotide binding]; other site 137722018293 putative Zn2+ binding site [ion binding]; other site 137722018294 AsnC family; Region: AsnC_trans_reg; pfam01037 137722018295 Serine hydrolase; Region: Ser_hydrolase; cl17834 137722018296 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 137722018297 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 137722018298 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 137722018299 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 137722018300 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722018301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722018302 dimer interface [polypeptide binding]; other site 137722018303 phosphorylation site [posttranslational modification] 137722018304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722018305 ATP binding site [chemical binding]; other site 137722018306 Mg2+ binding site [ion binding]; other site 137722018307 G-X-G motif; other site 137722018308 Response regulator receiver domain; Region: Response_reg; pfam00072 137722018309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018310 active site 137722018311 phosphorylation site [posttranslational modification] 137722018312 intermolecular recognition site; other site 137722018313 dimerization interface [polypeptide binding]; other site 137722018314 Uncharacterized conserved protein [Function unknown]; Region: COG3287 137722018315 FIST N domain; Region: FIST; pfam08495 137722018316 FIST C domain; Region: FIST_C; pfam10442 137722018317 Protein of unknown function (DUF779); Region: DUF779; pfam05610 137722018318 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 137722018319 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 137722018320 NAD(P) binding site [chemical binding]; other site 137722018321 catalytic residues [active] 137722018322 quinolinate synthetase; Provisional; Region: PRK09375 137722018323 L-aspartate oxidase; Provisional; Region: PRK06175 137722018324 FAD binding domain; Region: FAD_binding_2; pfam00890 137722018325 L-aspartate oxidase; Provisional; Region: PRK06175 137722018326 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 137722018327 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 137722018328 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 137722018329 dimerization interface [polypeptide binding]; other site 137722018330 active site 137722018331 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 137722018332 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 137722018333 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 137722018334 putative active site pocket [active] 137722018335 metal binding site [ion binding]; metal-binding site 137722018336 cell density-dependent motility repressor; Provisional; Region: PRK10082 137722018337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722018338 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722018339 dimerization interface [polypeptide binding]; other site 137722018340 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 137722018341 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 137722018342 Walker A motif/ATP binding site; other site 137722018343 Walker B motif; other site 137722018344 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722018345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018346 active site 137722018347 phosphorylation site [posttranslational modification] 137722018348 intermolecular recognition site; other site 137722018349 dimerization interface [polypeptide binding]; other site 137722018350 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722018351 DNA binding site [nucleotide binding] 137722018352 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 137722018353 DNA-binding site [nucleotide binding]; DNA binding site 137722018354 RNA-binding motif; other site 137722018355 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 137722018356 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 137722018357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722018358 S-adenosylmethionine binding site [chemical binding]; other site 137722018359 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 137722018360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018361 active site 137722018362 phosphorylation site [posttranslational modification] 137722018363 intermolecular recognition site; other site 137722018364 dimerization interface [polypeptide binding]; other site 137722018365 CheB methylesterase; Region: CheB_methylest; pfam01339 137722018366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018367 Response regulator receiver domain; Region: Response_reg; pfam00072 137722018368 active site 137722018369 phosphorylation site [posttranslational modification] 137722018370 intermolecular recognition site; other site 137722018371 dimerization interface [polypeptide binding]; other site 137722018372 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 137722018373 putative CheA interaction surface; other site 137722018374 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 137722018375 putative binding surface; other site 137722018376 active site 137722018377 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 137722018378 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 137722018379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722018380 ATP binding site [chemical binding]; other site 137722018381 Mg2+ binding site [ion binding]; other site 137722018382 G-X-G motif; other site 137722018383 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 137722018384 CheW-like domain; Region: CheW; pfam01584 137722018385 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 137722018386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018387 active site 137722018388 phosphorylation site [posttranslational modification] 137722018389 intermolecular recognition site; other site 137722018390 dimerization interface [polypeptide binding]; other site 137722018391 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 137722018392 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 137722018393 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 137722018394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 137722018395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 137722018396 Histidine kinase; Region: HisKA_2; pfam07568 137722018397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722018398 ATP binding site [chemical binding]; other site 137722018399 Mg2+ binding site [ion binding]; other site 137722018400 G-X-G motif; other site 137722018401 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 137722018402 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 137722018403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722018404 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722018405 DNA binding residues [nucleotide binding] 137722018406 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 137722018407 putative substrate binding pocket [chemical binding]; other site 137722018408 AC domain interface; other site 137722018409 catalytic triad [active] 137722018410 AB domain interface; other site 137722018411 interchain disulfide; other site 137722018412 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 137722018413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722018414 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 137722018415 dimerization interface [polypeptide binding]; other site 137722018416 substrate binding pocket [chemical binding]; other site 137722018417 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 137722018418 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 137722018419 putative metal binding site [ion binding]; other site 137722018420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722018421 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 137722018422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722018423 Walker A/P-loop; other site 137722018424 ATP binding site [chemical binding]; other site 137722018425 Q-loop/lid; other site 137722018426 ABC transporter signature motif; other site 137722018427 Walker B; other site 137722018428 D-loop; other site 137722018429 H-loop/switch region; other site 137722018430 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 137722018431 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 137722018432 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 137722018433 ligand binding site [chemical binding]; other site 137722018434 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 137722018435 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 137722018436 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 137722018437 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 137722018438 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722018439 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722018440 dimer interface [polypeptide binding]; other site 137722018441 putative CheW interface [polypeptide binding]; other site 137722018442 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 137722018443 Transcriptional regulator [Transcription]; Region: IclR; COG1414 137722018444 Bacterial transcriptional regulator; Region: IclR; pfam01614 137722018445 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 137722018446 EamA-like transporter family; Region: EamA; pfam00892 137722018447 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722018448 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722018449 Walker A/P-loop; other site 137722018450 ATP binding site [chemical binding]; other site 137722018451 Q-loop/lid; other site 137722018452 ABC transporter signature motif; other site 137722018453 Walker B; other site 137722018454 D-loop; other site 137722018455 H-loop/switch region; other site 137722018456 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722018457 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722018458 Walker A/P-loop; other site 137722018459 ATP binding site [chemical binding]; other site 137722018460 Q-loop/lid; other site 137722018461 ABC transporter signature motif; other site 137722018462 Walker B; other site 137722018463 D-loop; other site 137722018464 H-loop/switch region; other site 137722018465 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 137722018466 Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490 137722018467 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 137722018468 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 137722018469 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 137722018470 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 137722018471 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 137722018472 precorrin-3B synthase; Region: CobG; TIGR02435 137722018473 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 137722018474 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 137722018475 Precorrin-8X methylmutase; Region: CbiC; pfam02570 137722018476 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 137722018477 active site 137722018478 SAM binding site [chemical binding]; other site 137722018479 homodimer interface [polypeptide binding]; other site 137722018480 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 137722018481 active site 137722018482 SAM binding site [chemical binding]; other site 137722018483 homodimer interface [polypeptide binding]; other site 137722018484 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 137722018485 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 137722018486 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 137722018487 active site 137722018488 putative homodimer interface [polypeptide binding]; other site 137722018489 SAM binding site [chemical binding]; other site 137722018490 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 137722018491 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 137722018492 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 137722018493 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 137722018494 active site 137722018495 SAM binding site [chemical binding]; other site 137722018496 homodimer interface [polypeptide binding]; other site 137722018497 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 137722018498 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 137722018499 active site 137722018500 SAM binding site [chemical binding]; other site 137722018501 homodimer interface [polypeptide binding]; other site 137722018502 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 137722018503 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 137722018504 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 137722018505 putative FMN binding site [chemical binding]; other site 137722018506 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 137722018507 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 137722018508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 137722018509 short chain dehydrogenase; Provisional; Region: PRK06180 137722018510 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 137722018511 NADP binding site [chemical binding]; other site 137722018512 active site 137722018513 steroid binding site; other site 137722018514 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 137722018515 putative binding surface; other site 137722018516 active site 137722018517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722018518 ATP binding site [chemical binding]; other site 137722018519 Mg2+ binding site [ion binding]; other site 137722018520 G-X-G motif; other site 137722018521 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 137722018522 Response regulator receiver domain; Region: Response_reg; pfam00072 137722018523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018524 active site 137722018525 phosphorylation site [posttranslational modification] 137722018526 intermolecular recognition site; other site 137722018527 dimerization interface [polypeptide binding]; other site 137722018528 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 137722018529 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 137722018530 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 137722018531 HEAT repeats; Region: HEAT_2; pfam13646 137722018532 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 137722018533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018534 active site 137722018535 phosphorylation site [posttranslational modification] 137722018536 intermolecular recognition site; other site 137722018537 dimerization interface [polypeptide binding]; other site 137722018538 CheB methylesterase; Region: CheB_methylest; pfam01339 137722018539 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 137722018540 CheW-like domain; Region: CheW; pfam01584 137722018541 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 137722018542 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722018543 dimer interface [polypeptide binding]; other site 137722018544 putative CheW interface [polypeptide binding]; other site 137722018545 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722018546 dimer interface [polypeptide binding]; other site 137722018547 putative CheW interface [polypeptide binding]; other site 137722018548 CheC-like family; Region: CheC; pfam04509 137722018549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018550 Response regulator receiver domain; Region: Response_reg; pfam00072 137722018551 active site 137722018552 phosphorylation site [posttranslational modification] 137722018553 intermolecular recognition site; other site 137722018554 dimerization interface [polypeptide binding]; other site 137722018555 TPR repeat; Region: TPR_11; pfam13414 137722018556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722018557 binding surface 137722018558 TPR motif; other site 137722018559 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 137722018560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722018561 binding surface 137722018562 TPR motif; other site 137722018563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722018564 TPR motif; other site 137722018565 binding surface 137722018566 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 137722018567 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 137722018568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722018569 dimer interface [polypeptide binding]; other site 137722018570 conserved gate region; other site 137722018571 ABC-ATPase subunit interface; other site 137722018572 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 137722018573 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 137722018574 Walker A/P-loop; other site 137722018575 ATP binding site [chemical binding]; other site 137722018576 Q-loop/lid; other site 137722018577 ABC transporter signature motif; other site 137722018578 Walker B; other site 137722018579 D-loop; other site 137722018580 H-loop/switch region; other site 137722018581 NIL domain; Region: NIL; pfam09383 137722018582 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 137722018583 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 137722018584 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 137722018585 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 137722018586 active site 137722018587 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 137722018588 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 137722018589 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 137722018590 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 137722018591 NAD binding site [chemical binding]; other site 137722018592 dimerization interface [polypeptide binding]; other site 137722018593 product binding site; other site 137722018594 substrate binding site [chemical binding]; other site 137722018595 zinc binding site [ion binding]; other site 137722018596 catalytic residues [active] 137722018597 hypothetical protein; Provisional; Region: PRK02853 137722018598 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 137722018599 Low molecular weight phosphatase family; Region: LMWPc; cd00115 137722018600 active site 137722018601 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 137722018602 Cache domain; Region: Cache_1; pfam02743 137722018603 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722018604 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722018605 dimer interface [polypeptide binding]; other site 137722018606 phosphorylation site [posttranslational modification] 137722018607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722018608 ATP binding site [chemical binding]; other site 137722018609 Mg2+ binding site [ion binding]; other site 137722018610 G-X-G motif; other site 137722018611 Response regulator receiver domain; Region: Response_reg; pfam00072 137722018612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018613 active site 137722018614 phosphorylation site [posttranslational modification] 137722018615 intermolecular recognition site; other site 137722018616 dimerization interface [polypeptide binding]; other site 137722018617 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722018618 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722018619 catalytic residue [active] 137722018620 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 137722018621 rRNA binding site [nucleotide binding]; other site 137722018622 predicted 30S ribosome binding site; other site 137722018623 Maf-like protein; Region: Maf; pfam02545 137722018624 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 137722018625 active site 137722018626 dimer interface [polypeptide binding]; other site 137722018627 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 137722018628 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 137722018629 homodimer interface [polypeptide binding]; other site 137722018630 oligonucleotide binding site [chemical binding]; other site 137722018631 Domain of unknown function (DUF329); Region: DUF329; pfam03884 137722018632 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 137722018633 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 137722018634 active site 137722018635 catalytic residues [active] 137722018636 DNA binding site [nucleotide binding] 137722018637 Int/Topo IB signature motif; other site 137722018638 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722018639 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722018640 MASE1; Region: MASE1; cl17823 137722018641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722018642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722018643 dimer interface [polypeptide binding]; other site 137722018644 phosphorylation site [posttranslational modification] 137722018645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722018646 ATP binding site [chemical binding]; other site 137722018647 Mg2+ binding site [ion binding]; other site 137722018648 G-X-G motif; other site 137722018649 Response regulator receiver domain; Region: Response_reg; pfam00072 137722018650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018651 active site 137722018652 phosphorylation site [posttranslational modification] 137722018653 intermolecular recognition site; other site 137722018654 dimerization interface [polypeptide binding]; other site 137722018655 CHAT domain; Region: CHAT; cl17868 137722018656 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722018657 MarR family; Region: MarR_2; pfam12802 137722018658 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 137722018659 active site 137722018660 catalytic residues [active] 137722018661 DNA binding site [nucleotide binding] 137722018662 Int/Topo IB signature motif; other site 137722018663 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 137722018664 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722018665 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722018666 Transcriptional regulators [Transcription]; Region: PurR; COG1609 137722018667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 137722018668 DNA binding site [nucleotide binding] 137722018669 domain linker motif; other site 137722018670 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 137722018671 putative dimerization interface [polypeptide binding]; other site 137722018672 putative ligand binding site [chemical binding]; other site 137722018673 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 137722018674 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 137722018675 inhibitor site; inhibition site 137722018676 active site 137722018677 dimer interface [polypeptide binding]; other site 137722018678 catalytic residue [active] 137722018679 benzoate transport; Region: 2A0115; TIGR00895 137722018680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722018681 putative substrate translocation pore; other site 137722018682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722018683 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 137722018684 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 137722018685 NAD binding site [chemical binding]; other site 137722018686 catalytic residues [active] 137722018687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 137722018688 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722018689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722018690 Walker A/P-loop; other site 137722018691 ATP binding site [chemical binding]; other site 137722018692 Q-loop/lid; other site 137722018693 ABC transporter signature motif; other site 137722018694 Walker B; other site 137722018695 D-loop; other site 137722018696 H-loop/switch region; other site 137722018697 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722018698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 137722018699 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722018700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722018701 dimer interface [polypeptide binding]; other site 137722018702 conserved gate region; other site 137722018703 putative PBP binding loops; other site 137722018704 ABC-ATPase subunit interface; other site 137722018705 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 137722018706 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 137722018707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722018708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722018709 Patatin-like phospholipase; Region: Patatin; pfam01734 137722018710 active site 137722018711 nucleophile elbow; other site 137722018712 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 137722018713 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 137722018714 active site 137722018715 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 137722018716 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 137722018717 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 137722018718 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 137722018719 putative NADP binding site [chemical binding]; other site 137722018720 active site 137722018721 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 137722018722 Thioesterase domain; Region: Thioesterase; pfam00975 137722018723 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 137722018724 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722018725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722018726 putative CheW interface [polypeptide binding]; other site 137722018727 Hemerythrin; Region: Hemerythrin; cd12107 137722018728 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 137722018729 AMP-binding domain protein; Validated; Region: PRK08315 137722018730 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722018731 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 137722018732 acyl-activating enzyme (AAE) consensus motif; other site 137722018733 acyl-activating enzyme (AAE) consensus motif; other site 137722018734 putative AMP binding site [chemical binding]; other site 137722018735 putative active site [active] 137722018736 putative CoA binding site [chemical binding]; other site 137722018737 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722018738 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722018739 non-specific DNA binding site [nucleotide binding]; other site 137722018740 salt bridge; other site 137722018741 sequence-specific DNA binding site [nucleotide binding]; other site 137722018742 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 137722018743 Fusaric acid resistance protein family; Region: FUSC; pfam04632 137722018744 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 137722018745 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722018746 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 137722018747 putative DNA binding site [nucleotide binding]; other site 137722018748 putative Zn2+ binding site [ion binding]; other site 137722018749 AsnC family; Region: AsnC_trans_reg; pfam01037 137722018750 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 137722018751 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 137722018752 hexamer interface [polypeptide binding]; other site 137722018753 ligand binding site [chemical binding]; other site 137722018754 putative active site [active] 137722018755 NAD(P) binding site [chemical binding]; other site 137722018756 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722018757 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722018758 TM-ABC transporter signature motif; other site 137722018759 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722018760 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722018761 TM-ABC transporter signature motif; other site 137722018762 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722018763 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722018764 Walker A/P-loop; other site 137722018765 ATP binding site [chemical binding]; other site 137722018766 Q-loop/lid; other site 137722018767 ABC transporter signature motif; other site 137722018768 Walker B; other site 137722018769 D-loop; other site 137722018770 H-loop/switch region; other site 137722018771 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722018772 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722018773 Walker A/P-loop; other site 137722018774 ATP binding site [chemical binding]; other site 137722018775 Q-loop/lid; other site 137722018776 ABC transporter signature motif; other site 137722018777 Walker B; other site 137722018778 D-loop; other site 137722018779 H-loop/switch region; other site 137722018780 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722018781 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722018782 dimer interface [polypeptide binding]; other site 137722018783 putative CheW interface [polypeptide binding]; other site 137722018784 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722018785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018786 active site 137722018787 phosphorylation site [posttranslational modification] 137722018788 intermolecular recognition site; other site 137722018789 dimerization interface [polypeptide binding]; other site 137722018790 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722018791 DNA binding site [nucleotide binding] 137722018792 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722018793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722018794 dimer interface [polypeptide binding]; other site 137722018795 phosphorylation site [posttranslational modification] 137722018796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722018797 ATP binding site [chemical binding]; other site 137722018798 Mg2+ binding site [ion binding]; other site 137722018799 G-X-G motif; other site 137722018800 Response regulator receiver domain; Region: Response_reg; pfam00072 137722018801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722018802 active site 137722018803 phosphorylation site [posttranslational modification] 137722018804 intermolecular recognition site; other site 137722018805 dimerization interface [polypeptide binding]; other site 137722018806 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 137722018807 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722018808 FAD binding site [chemical binding]; other site 137722018809 substrate binding pocket [chemical binding]; other site 137722018810 catalytic base [active] 137722018811 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 137722018812 ATP-grasp domain; Region: ATP-grasp_4; cl17255 137722018813 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 137722018814 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 137722018815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722018816 Walker A/P-loop; other site 137722018817 ATP binding site [chemical binding]; other site 137722018818 Q-loop/lid; other site 137722018819 ABC transporter signature motif; other site 137722018820 Walker B; other site 137722018821 D-loop; other site 137722018822 H-loop/switch region; other site 137722018823 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 137722018824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722018825 Walker A/P-loop; other site 137722018826 ATP binding site [chemical binding]; other site 137722018827 Q-loop/lid; other site 137722018828 ABC transporter signature motif; other site 137722018829 Walker B; other site 137722018830 D-loop; other site 137722018831 H-loop/switch region; other site 137722018832 Predicted membrane protein [Function unknown]; Region: COG2259 137722018833 NifQ; Region: NifQ; pfam04891 137722018834 formate dehydrogenase; Provisional; Region: PRK07574 137722018835 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 137722018836 dimerization interface [polypeptide binding]; other site 137722018837 ligand binding site [chemical binding]; other site 137722018838 NAD binding site [chemical binding]; other site 137722018839 catalytic site [active] 137722018840 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722018841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722018842 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 137722018843 dimerization interface [polypeptide binding]; other site 137722018844 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 137722018845 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 137722018846 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 137722018847 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 137722018848 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 137722018849 active site 137722018850 nucleotide binding site [chemical binding]; other site 137722018851 HIGH motif; other site 137722018852 KMSKS motif; other site 137722018853 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 137722018854 nudix motif; other site 137722018855 NAD synthetase; Provisional; Region: PRK13981 137722018856 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 137722018857 multimer interface [polypeptide binding]; other site 137722018858 active site 137722018859 catalytic triad [active] 137722018860 protein interface 1 [polypeptide binding]; other site 137722018861 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 137722018862 homodimer interface [polypeptide binding]; other site 137722018863 NAD binding pocket [chemical binding]; other site 137722018864 ATP binding pocket [chemical binding]; other site 137722018865 Mg binding site [ion binding]; other site 137722018866 active-site loop [active] 137722018867 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 137722018868 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 137722018869 active site 137722018870 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 137722018871 catalytic triad [active] 137722018872 conserved cis-peptide bond; other site 137722018873 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 137722018874 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 137722018875 Predicted membrane protein [Function unknown]; Region: COG3766 137722018876 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 137722018877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722018878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722018879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722018880 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 137722018881 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 137722018882 putative acyl-acceptor binding pocket; other site 137722018883 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722018884 acyl-activating enzyme (AAE) consensus motif; other site 137722018885 AMP binding site [chemical binding]; other site 137722018886 active site 137722018887 CoA binding site [chemical binding]; other site 137722018888 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 137722018889 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 137722018890 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 137722018891 putative acyl-acceptor binding pocket; other site 137722018892 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 137722018893 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 137722018894 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 137722018895 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 137722018896 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 137722018897 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 137722018898 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 137722018899 N-terminal plug; other site 137722018900 ligand-binding site [chemical binding]; other site 137722018901 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 137722018902 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722018903 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722018904 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 137722018905 Protein export membrane protein; Region: SecD_SecF; cl14618 137722018906 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 137722018907 RNA polymerase sigma factor; Reviewed; Region: PRK05602 137722018908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722018909 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722018910 Heavy-metal resistance; Region: Metal_resist; pfam13801 137722018911 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722018912 dimerization interface [polypeptide binding]; other site 137722018913 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722018914 dimer interface [polypeptide binding]; other site 137722018915 putative CheW interface [polypeptide binding]; other site 137722018916 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 137722018917 classical (c) SDRs; Region: SDR_c; cd05233 137722018918 NAD(P) binding site [chemical binding]; other site 137722018919 active site 137722018920 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 137722018921 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 137722018922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 137722018923 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 137722018924 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 137722018925 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 137722018926 tetramer interface [polypeptide binding]; other site 137722018927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722018928 catalytic residue [active] 137722018929 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 137722018930 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 137722018931 RNA binding surface [nucleotide binding]; other site 137722018932 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 137722018933 active site 137722018934 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 137722018935 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 137722018936 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 137722018937 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 137722018938 DNA binding residues [nucleotide binding] 137722018939 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 137722018940 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 137722018941 MarR family; Region: MarR_2; pfam12802 137722018942 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 137722018943 serine racemase; Region: PLN02970 137722018944 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 137722018945 tetramer interface [polypeptide binding]; other site 137722018946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722018947 catalytic residue [active] 137722018948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722018949 Coenzyme A binding pocket [chemical binding]; other site 137722018950 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 137722018951 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 137722018952 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 137722018953 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722018954 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722018955 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722018956 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722018957 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 137722018958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722018959 DNA-binding site [nucleotide binding]; DNA binding site 137722018960 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722018961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722018962 homodimer interface [polypeptide binding]; other site 137722018963 catalytic residue [active] 137722018964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722018965 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 137722018966 putative substrate binding pocket [chemical binding]; other site 137722018967 putative dimerization interface [polypeptide binding]; other site 137722018968 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 137722018969 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 137722018970 active site 137722018971 catalytic tetrad [active] 137722018972 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 137722018973 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 137722018974 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 137722018975 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 137722018976 active site 137722018977 FMN binding site [chemical binding]; other site 137722018978 substrate binding site [chemical binding]; other site 137722018979 homotetramer interface [polypeptide binding]; other site 137722018980 catalytic residue [active] 137722018981 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 137722018982 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722018983 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 137722018984 P-loop; other site 137722018985 Magnesium ion binding site [ion binding]; other site 137722018986 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 137722018987 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 137722018988 tetrameric interface [polypeptide binding]; other site 137722018989 NAD binding site [chemical binding]; other site 137722018990 catalytic residues [active] 137722018991 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722018992 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 137722018993 substrate binding pocket [chemical binding]; other site 137722018994 FAD binding site [chemical binding]; other site 137722018995 catalytic base [active] 137722018996 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 137722018997 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 137722018998 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722018999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722019000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722019001 dimerization interface [polypeptide binding]; other site 137722019002 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 137722019003 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722019004 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 137722019005 P-loop; other site 137722019006 Magnesium ion binding site [ion binding]; other site 137722019007 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 137722019008 Caspase domain; Region: Peptidase_C14; pfam00656 137722019009 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 137722019010 S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692 137722019011 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 137722019012 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 137722019013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722019014 Walker A/P-loop; other site 137722019015 ATP binding site [chemical binding]; other site 137722019016 Q-loop/lid; other site 137722019017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722019018 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 137722019019 Q-loop/lid; other site 137722019020 ABC transporter signature motif; other site 137722019021 Walker B; other site 137722019022 D-loop; other site 137722019023 H-loop/switch region; other site 137722019024 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722019025 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722019026 ligand binding site [chemical binding]; other site 137722019027 flexible hinge region; other site 137722019028 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 137722019029 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722019030 Walker A/P-loop; other site 137722019031 ATP binding site [chemical binding]; other site 137722019032 Q-loop/lid; other site 137722019033 ABC transporter signature motif; other site 137722019034 Walker B; other site 137722019035 D-loop; other site 137722019036 H-loop/switch region; other site 137722019037 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722019038 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 137722019039 Walker A/P-loop; other site 137722019040 ATP binding site [chemical binding]; other site 137722019041 Q-loop/lid; other site 137722019042 ABC transporter signature motif; other site 137722019043 Walker B; other site 137722019044 D-loop; other site 137722019045 H-loop/switch region; other site 137722019046 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 137722019047 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 137722019048 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 137722019049 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 137722019050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722019051 dimer interface [polypeptide binding]; other site 137722019052 conserved gate region; other site 137722019053 ABC-ATPase subunit interface; other site 137722019054 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 137722019055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722019056 dimer interface [polypeptide binding]; other site 137722019057 conserved gate region; other site 137722019058 putative PBP binding loops; other site 137722019059 ABC-ATPase subunit interface; other site 137722019060 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 137722019061 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 137722019062 putative ADP-binding pocket [chemical binding]; other site 137722019063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722019064 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722019065 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 137722019066 catalytic core [active] 137722019067 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 137722019068 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722019069 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 137722019070 NodB motif; other site 137722019071 putative active site [active] 137722019072 putative catalytic site [active] 137722019073 putative Zn binding site [ion binding]; other site 137722019074 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 137722019075 Fic/DOC family; Region: Fic; cl00960 137722019076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722019077 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 137722019078 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 137722019079 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 137722019080 Calx-beta domain; Region: Calx-beta; pfam03160 137722019081 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 137722019082 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 137722019083 Walker A/P-loop; other site 137722019084 ATP binding site [chemical binding]; other site 137722019085 Q-loop/lid; other site 137722019086 ABC transporter signature motif; other site 137722019087 Walker B; other site 137722019088 D-loop; other site 137722019089 H-loop/switch region; other site 137722019090 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 137722019091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722019092 dimer interface [polypeptide binding]; other site 137722019093 conserved gate region; other site 137722019094 putative PBP binding loops; other site 137722019095 ABC-ATPase subunit interface; other site 137722019096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722019097 dimer interface [polypeptide binding]; other site 137722019098 conserved gate region; other site 137722019099 ABC-ATPase subunit interface; other site 137722019100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722019101 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 137722019102 substrate binding pocket [chemical binding]; other site 137722019103 membrane-bound complex binding site; other site 137722019104 hinge residues; other site 137722019105 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 137722019106 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 137722019107 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 137722019108 pyruvate kinase; Provisional; Region: PRK06247 137722019109 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 137722019110 domain interfaces; other site 137722019111 active site 137722019112 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 137722019113 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 137722019114 AsnC family; Region: AsnC_trans_reg; pfam01037 137722019115 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 137722019116 active site 137722019117 Right handed beta helix region; Region: Beta_helix; pfam13229 137722019118 Right handed beta helix region; Region: Beta_helix; pfam13229 137722019119 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 137722019120 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 137722019121 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 137722019122 putative ion selectivity filter; other site 137722019123 putative pore gating glutamate residue; other site 137722019124 putative H+/Cl- coupling transport residue; other site 137722019125 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 137722019126 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 137722019127 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 137722019128 active site 137722019129 catalytic tetrad [active] 137722019130 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 137722019131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 137722019132 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 137722019133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722019134 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 137722019135 dimerization interface [polypeptide binding]; other site 137722019136 substrate binding pocket [chemical binding]; other site 137722019137 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 137722019138 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 137722019139 HPP family; Region: HPP; pfam04982 137722019140 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 137722019141 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 137722019142 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 137722019143 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 137722019144 DNA binding residues [nucleotide binding] 137722019145 dimer interface [polypeptide binding]; other site 137722019146 [2Fe-2S] cluster binding site [ion binding]; other site 137722019147 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 137722019148 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 137722019149 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 137722019150 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 137722019151 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 137722019152 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 137722019153 putative ligand binding site [chemical binding]; other site 137722019154 NAD binding site [chemical binding]; other site 137722019155 catalytic site [active] 137722019156 benzoate transport; Region: 2A0115; TIGR00895 137722019157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722019158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722019159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722019160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722019161 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 137722019162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 137722019163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 137722019164 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 137722019165 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 137722019166 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722019167 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722019168 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 137722019169 Protein export membrane protein; Region: SecD_SecF; cl14618 137722019170 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 137722019171 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 137722019172 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722019173 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 137722019174 catalytic residues [active] 137722019175 catalytic nucleophile [active] 137722019176 Recombinase; Region: Recombinase; pfam07508 137722019177 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 137722019178 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722019179 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722019180 DNA binding residues [nucleotide binding] 137722019181 dimerization interface [polypeptide binding]; other site 137722019182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722019183 sequence-specific DNA binding site [nucleotide binding]; other site 137722019184 salt bridge; other site 137722019185 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 137722019186 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 137722019187 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 137722019188 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 137722019189 active site residue [active] 137722019190 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722019191 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722019192 MarR family; Region: MarR_2; pfam12802 137722019193 Transcriptional regulators [Transcription]; Region: MarR; COG1846 137722019194 Part of AAA domain; Region: AAA_19; pfam13245 137722019195 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 137722019196 AAA domain; Region: AAA_12; pfam13087 137722019197 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 137722019198 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 137722019199 tellurite resistance protein terB; Region: terB; cd07176 137722019200 putative metal binding site [ion binding]; other site 137722019201 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 137722019202 AAA ATPase domain; Region: AAA_16; pfam13191 137722019203 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 137722019204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 137722019205 ATP binding site [chemical binding]; other site 137722019206 putative Mg++ binding site [ion binding]; other site 137722019207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722019208 nucleotide binding region [chemical binding]; other site 137722019209 ATP-binding site [chemical binding]; other site 137722019210 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722019211 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722019212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722019213 Integrase core domain; Region: rve; pfam00665 137722019214 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722019215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722019216 Walker A motif; other site 137722019217 ATP binding site [chemical binding]; other site 137722019218 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 137722019219 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 137722019220 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722019221 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 137722019222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722019223 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722019224 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722019225 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722019226 Integrase core domain; Region: rve_3; pfam13683 137722019227 HTH-like domain; Region: HTH_21; pfam13276 137722019228 Integrase core domain; Region: rve; pfam00665 137722019229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722019230 Transposase; Region: HTH_Tnp_1; cl17663 137722019231 putative transposase OrfB; Reviewed; Region: PHA02517 137722019232 Putative glucoamylase; Region: Glycoamylase; pfam10091 137722019233 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 137722019234 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 137722019235 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 137722019236 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 137722019237 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 137722019238 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 137722019239 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 137722019240 Soluble P-type ATPase [General function prediction only]; Region: COG4087 137722019241 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 137722019242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722019243 active site 137722019244 phosphorylation site [posttranslational modification] 137722019245 intermolecular recognition site; other site 137722019246 response regulator; Provisional; Region: PRK13435 137722019247 CheB methylesterase; Region: CheB_methylest; pfam01339 137722019248 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 137722019249 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 137722019250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722019251 S-adenosylmethionine binding site [chemical binding]; other site 137722019252 Prefoldin subunit; Region: Prefoldin_2; pfam01920 137722019253 PAS domain; Region: PAS_10; pfam13596 137722019254 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722019255 putative active site [active] 137722019256 heme pocket [chemical binding]; other site 137722019257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 137722019258 HWE histidine kinase; Region: HWE_HK; smart00911 137722019259 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 137722019260 PAS domain; Region: PAS_9; pfam13426 137722019261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722019262 putative active site [active] 137722019263 heme pocket [chemical binding]; other site 137722019264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 137722019265 Histidine kinase; Region: HisKA_2; pfam07568 137722019266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722019267 ATP binding site [chemical binding]; other site 137722019268 Mg2+ binding site [ion binding]; other site 137722019269 G-X-G motif; other site 137722019270 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 137722019271 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 137722019272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722019273 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722019274 active site 137722019275 phosphorylation site [posttranslational modification] 137722019276 dimerization interface [polypeptide binding]; other site 137722019277 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722019278 DNA binding residues [nucleotide binding] 137722019279 dimerization interface [polypeptide binding]; other site 137722019280 CheB methylesterase; Region: CheB_methylest; pfam01339 137722019281 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 137722019282 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 137722019283 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 137722019284 PAS domain; Region: PAS_10; pfam13596 137722019285 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 137722019286 GAF domain; Region: GAF; pfam01590 137722019287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722019288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722019289 dimer interface [polypeptide binding]; other site 137722019290 phosphorylation site [posttranslational modification] 137722019291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722019292 ATP binding site [chemical binding]; other site 137722019293 Mg2+ binding site [ion binding]; other site 137722019294 G-X-G motif; other site 137722019295 Response regulator receiver domain; Region: Response_reg; pfam00072 137722019296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722019297 active site 137722019298 phosphorylation site [posttranslational modification] 137722019299 intermolecular recognition site; other site 137722019300 dimerization interface [polypeptide binding]; other site 137722019301 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 137722019302 Transglutaminase/protease-like homologues; Region: TGc; smart00460 137722019303 WYL domain; Region: WYL; pfam13280 137722019304 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 137722019305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722019306 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722019307 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722019308 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722019309 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722019310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722019311 Transposase; Region: HTH_Tnp_1; cl17663 137722019312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 137722019313 Histidine kinase; Region: HisKA_3; pfam07730 137722019314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722019315 ATP binding site [chemical binding]; other site 137722019316 Mg2+ binding site [ion binding]; other site 137722019317 G-X-G motif; other site 137722019318 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722019319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722019320 active site 137722019321 phosphorylation site [posttranslational modification] 137722019322 intermolecular recognition site; other site 137722019323 dimerization interface [polypeptide binding]; other site 137722019324 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722019325 DNA binding residues [nucleotide binding] 137722019326 dimerization interface [polypeptide binding]; other site 137722019327 haemagglutination activity domain; Region: Haemagg_act; smart00912 137722019328 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 137722019329 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722019330 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 137722019331 ornithine decarboxylase; Provisional; Region: PRK13578 137722019332 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 137722019333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 137722019334 catalytic residue [active] 137722019335 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 137722019336 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 137722019337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 137722019338 Coenzyme A binding pocket [chemical binding]; other site 137722019339 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 137722019340 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 137722019341 oligomer interface [polypeptide binding]; other site 137722019342 Rod binding protein; Region: Rod-binding; pfam10135 137722019343 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 137722019344 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 137722019345 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 137722019346 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 137722019347 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 137722019348 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 137722019349 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 137722019350 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 137722019351 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 137722019352 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 137722019353 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 137722019354 ligand binding site [chemical binding]; other site 137722019355 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 137722019356 flagellar motor protein MotA; Validated; Region: PRK09110 137722019357 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 137722019358 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 137722019359 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 137722019360 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 137722019361 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 137722019362 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 137722019363 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 137722019364 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 137722019365 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 137722019366 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 137722019367 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 137722019368 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 137722019369 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 137722019370 Uncharacterized conserved protein [Function unknown]; Region: COG3334 137722019371 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 137722019372 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 137722019373 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 137722019374 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 137722019375 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 137722019376 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 137722019377 flagellar assembly protein H; Validated; Region: fliH; PRK06032 137722019378 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 137722019379 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 137722019380 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 137722019381 FliG C-terminal domain; Region: FliG_C; pfam01706 137722019382 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722019383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722019384 DNA binding site [nucleotide binding] 137722019385 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 137722019386 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 137722019387 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 137722019388 Flagellar protein FlaF; Region: FlaF; pfam07309 137722019389 Flagellar protein FlbT; Region: FlbT; pfam07378 137722019390 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 137722019391 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 137722019392 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 137722019393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722019394 DNA-binding site [nucleotide binding]; DNA binding site 137722019395 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722019396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722019397 homodimer interface [polypeptide binding]; other site 137722019398 catalytic residue [active] 137722019399 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 137722019400 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 137722019401 Walker A motif/ATP binding site; other site 137722019402 Walker B motif; other site 137722019403 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 137722019404 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 137722019405 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 137722019406 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 137722019407 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 137722019408 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 137722019409 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722019410 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722019411 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 137722019412 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 137722019413 Walker A/P-loop; other site 137722019414 ATP binding site [chemical binding]; other site 137722019415 Q-loop/lid; other site 137722019416 ABC transporter signature motif; other site 137722019417 Walker B; other site 137722019418 D-loop; other site 137722019419 H-loop/switch region; other site 137722019420 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 137722019421 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 137722019422 ABC-ATPase subunit interface; other site 137722019423 dimer interface [polypeptide binding]; other site 137722019424 putative PBP binding regions; other site 137722019425 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 137722019426 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 137722019427 ABC-ATPase subunit interface; other site 137722019428 dimer interface [polypeptide binding]; other site 137722019429 putative PBP binding regions; other site 137722019430 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 137722019431 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 137722019432 intersubunit interface [polypeptide binding]; other site 137722019433 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 137722019434 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 137722019435 cation binding site [ion binding]; other site 137722019436 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 137722019437 FHIPEP family; Region: FHIPEP; pfam00771 137722019438 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 137722019439 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 137722019440 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 137722019441 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 137722019442 dihydropteroate synthase; Region: DHPS; TIGR01496 137722019443 substrate binding pocket [chemical binding]; other site 137722019444 dimer interface [polypeptide binding]; other site 137722019445 inhibitor binding site; inhibition site 137722019446 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 137722019447 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 137722019448 active site 137722019449 substrate binding site [chemical binding]; other site 137722019450 metal binding site [ion binding]; metal-binding site 137722019451 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 137722019452 dimer interface [polypeptide binding]; other site 137722019453 substrate binding site [chemical binding]; other site 137722019454 ATP binding site [chemical binding]; other site 137722019455 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 137722019456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722019457 active site 137722019458 phosphorylation site [posttranslational modification] 137722019459 intermolecular recognition site; other site 137722019460 dimerization interface [polypeptide binding]; other site 137722019461 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722019462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722019463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 137722019464 dimer interface [polypeptide binding]; other site 137722019465 phosphorylation site [posttranslational modification] 137722019466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722019467 ATP binding site [chemical binding]; other site 137722019468 Mg2+ binding site [ion binding]; other site 137722019469 G-X-G motif; other site 137722019470 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 137722019471 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 137722019472 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 137722019473 Subunit I/III interface [polypeptide binding]; other site 137722019474 Subunit III/IV interface [polypeptide binding]; other site 137722019475 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 137722019476 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 137722019477 D-pathway; other site 137722019478 Putative ubiquinol binding site [chemical binding]; other site 137722019479 Low-spin heme (heme b) binding site [chemical binding]; other site 137722019480 Putative water exit pathway; other site 137722019481 Binuclear center (heme o3/CuB) [ion binding]; other site 137722019482 K-pathway; other site 137722019483 Putative proton exit pathway; other site 137722019484 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 137722019485 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 137722019486 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 137722019487 metabolite-proton symporter; Region: 2A0106; TIGR00883 137722019488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722019489 putative substrate translocation pore; other site 137722019490 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 137722019491 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 137722019492 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 137722019493 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 137722019494 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 137722019495 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 137722019496 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 137722019497 Glutamate binding site [chemical binding]; other site 137722019498 NAD binding site [chemical binding]; other site 137722019499 catalytic residues [active] 137722019500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722019501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722019502 putative substrate translocation pore; other site 137722019503 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 137722019504 alpha-galactosidase; Provisional; Region: PRK15076 137722019505 NAD(P) binding site [chemical binding]; other site 137722019506 LDH/MDH dimer interface [polypeptide binding]; other site 137722019507 substrate binding site [chemical binding]; other site 137722019508 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 137722019509 beta-galactosidase; Region: BGL; TIGR03356 137722019510 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 137722019511 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 137722019512 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 137722019513 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 137722019514 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 137722019515 ligand binding site [chemical binding]; other site 137722019516 flexible hinge region; other site 137722019517 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 137722019518 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722019519 dimerization interface [polypeptide binding]; other site 137722019520 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722019521 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722019522 dimer interface [polypeptide binding]; other site 137722019523 putative CheW interface [polypeptide binding]; other site 137722019524 acyl carrier protein; Provisional; Region: PRK07081 137722019525 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 137722019526 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 137722019527 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 137722019528 active site 137722019529 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 137722019530 dimer interface [polypeptide binding]; other site 137722019531 motif 1; other site 137722019532 active site 137722019533 motif 2; other site 137722019534 motif 3; other site 137722019535 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 137722019536 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 137722019537 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 137722019538 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 137722019539 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 137722019540 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722019541 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722019542 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 137722019543 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 137722019544 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 137722019545 metal binding site [ion binding]; metal-binding site 137722019546 allantoate amidohydrolase; Reviewed; Region: PRK09290 137722019547 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 137722019548 active site 137722019549 metal binding site [ion binding]; metal-binding site 137722019550 dimer interface [polypeptide binding]; other site 137722019551 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 137722019552 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 137722019553 Trp docking motif [polypeptide binding]; other site 137722019554 putative active site [active] 137722019555 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 137722019556 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 137722019557 putative C-terminal domain interface [polypeptide binding]; other site 137722019558 putative GSH binding site (G-site) [chemical binding]; other site 137722019559 putative dimer interface [polypeptide binding]; other site 137722019560 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 137722019561 N-terminal domain interface [polypeptide binding]; other site 137722019562 dimer interface [polypeptide binding]; other site 137722019563 substrate binding pocket (H-site) [chemical binding]; other site 137722019564 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 137722019565 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 137722019566 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722019567 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 137722019568 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 137722019569 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 137722019570 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 137722019571 Ligand binding site [chemical binding]; other site 137722019572 Electron transfer flavoprotein domain; Region: ETF; pfam01012 137722019573 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 137722019574 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 137722019575 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 137722019576 beta-galactosidase; Region: BGL; TIGR03356 137722019577 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 137722019578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722019579 dimerization interface [polypeptide binding]; other site 137722019580 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722019581 dimer interface [polypeptide binding]; other site 137722019582 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722019583 putative CheW interface [polypeptide binding]; other site 137722019584 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 137722019585 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 137722019586 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 137722019587 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 137722019588 Walker A/P-loop; other site 137722019589 ATP binding site [chemical binding]; other site 137722019590 Q-loop/lid; other site 137722019591 ABC transporter signature motif; other site 137722019592 Walker B; other site 137722019593 D-loop; other site 137722019594 H-loop/switch region; other site 137722019595 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 137722019596 Permease; Region: Permease; pfam02405 137722019597 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 137722019598 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 137722019599 active site 137722019600 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 137722019601 dimer interface [polypeptide binding]; other site 137722019602 substrate binding site [chemical binding]; other site 137722019603 catalytic residues [active] 137722019604 replicative DNA helicase; Provisional; Region: PRK09165 137722019605 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 137722019606 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 137722019607 Walker A motif; other site 137722019608 ATP binding site [chemical binding]; other site 137722019609 Walker B motif; other site 137722019610 DNA binding loops [nucleotide binding] 137722019611 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 137722019612 Cytochrome C' Region: Cytochrom_C_2; pfam01322 137722019613 Cytochrome c; Region: Cytochrom_C; pfam00034 137722019614 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 137722019615 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 137722019616 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 137722019617 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 137722019618 oligomer interface [polypeptide binding]; other site 137722019619 metal binding site [ion binding]; metal-binding site 137722019620 metal binding site [ion binding]; metal-binding site 137722019621 putative Cl binding site [ion binding]; other site 137722019622 basic sphincter; other site 137722019623 hydrophobic gate; other site 137722019624 periplasmic entrance; other site 137722019625 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 137722019626 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 137722019627 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 137722019628 active site 137722019629 CHASE domain; Region: CHASE; pfam03924 137722019630 PAS fold; Region: PAS_4; pfam08448 137722019631 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 137722019632 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 137722019633 metal binding site [ion binding]; metal-binding site 137722019634 active site 137722019635 I-site; other site 137722019636 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 137722019637 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013 137722019638 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 137722019639 metal binding site [ion binding]; metal-binding site 137722019640 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722019641 Winged helix-turn helix; Region: HTH_29; pfam13551 137722019642 Winged helix-turn helix; Region: HTH_33; pfam13592 137722019643 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722019644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 137722019645 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 137722019646 EamA-like transporter family; Region: EamA; pfam00892 137722019647 EamA-like transporter family; Region: EamA; pfam00892 137722019648 Predicted membrane protein [Function unknown]; Region: COG2259 137722019649 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 137722019650 active site 137722019651 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 137722019652 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 137722019653 Permease; Region: Permease; pfam02405 137722019654 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 137722019655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722019656 Walker A/P-loop; other site 137722019657 ATP binding site [chemical binding]; other site 137722019658 Q-loop/lid; other site 137722019659 ABC transporter signature motif; other site 137722019660 Walker B; other site 137722019661 D-loop; other site 137722019662 H-loop/switch region; other site 137722019663 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 137722019664 mce related protein; Region: MCE; pfam02470 137722019665 Protein of unknown function (DUF330); Region: DUF330; cl01135 137722019666 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 137722019667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722019668 putative active site [active] 137722019669 heme pocket [chemical binding]; other site 137722019670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722019671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722019672 dimer interface [polypeptide binding]; other site 137722019673 phosphorylation site [posttranslational modification] 137722019674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722019675 ATP binding site [chemical binding]; other site 137722019676 Mg2+ binding site [ion binding]; other site 137722019677 G-X-G motif; other site 137722019678 HNH endonuclease; Region: HNH_2; pfam13391 137722019679 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 137722019680 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 137722019681 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 137722019682 active site 137722019683 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 137722019684 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 137722019685 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 137722019686 Fic/DOC family; Region: Fic; pfam02661 137722019687 Hemerythrin; Region: Hemerythrin; cd12107 137722019688 Fe binding site [ion binding]; other site 137722019689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722019690 TPR motif; other site 137722019691 binding surface 137722019692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722019693 binding surface 137722019694 TPR motif; other site 137722019695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722019696 binding surface 137722019697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722019698 TPR repeat; Region: TPR_11; pfam13414 137722019699 binding surface 137722019700 TPR motif; other site 137722019701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722019702 binding surface 137722019703 TPR repeat; Region: TPR_11; pfam13414 137722019704 TPR motif; other site 137722019705 Tetratricopeptide repeat; Region: TPR_16; pfam13432 137722019706 PBP superfamily domain; Region: PBP_like_2; pfam12849 137722019707 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 137722019708 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 137722019709 MPT binding site; other site 137722019710 trimer interface [polypeptide binding]; other site 137722019711 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 137722019712 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 137722019713 N-acetyl-D-glucosamine binding site [chemical binding]; other site 137722019714 catalytic residue [active] 137722019715 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 137722019716 Fe-S cluster binding site [ion binding]; other site 137722019717 active site 137722019718 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 137722019719 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 137722019720 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 137722019721 mannonate dehydratase; Provisional; Region: PRK03906 137722019722 mannonate dehydratase; Region: uxuA; TIGR00695 137722019723 DctM-like transporters; Region: DctM; pfam06808 137722019724 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 137722019725 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 137722019726 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 137722019727 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 137722019728 putative oxidoreductase; Provisional; Region: PRK10083 137722019729 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 137722019730 putative NAD(P) binding site [chemical binding]; other site 137722019731 catalytic Zn binding site [ion binding]; other site 137722019732 structural Zn binding site [ion binding]; other site 137722019733 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 137722019734 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 137722019735 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 137722019736 Transcriptional regulators [Transcription]; Region: GntR; COG1802 137722019737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722019738 DNA-binding site [nucleotide binding]; DNA binding site 137722019739 FCD domain; Region: FCD; pfam07729 137722019740 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722019741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722019742 dimer interface [polypeptide binding]; other site 137722019743 conserved gate region; other site 137722019744 putative PBP binding loops; other site 137722019745 ABC-ATPase subunit interface; other site 137722019746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 137722019747 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 137722019748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722019749 Walker A/P-loop; other site 137722019750 ATP binding site [chemical binding]; other site 137722019751 Q-loop/lid; other site 137722019752 ABC transporter signature motif; other site 137722019753 Walker B; other site 137722019754 D-loop; other site 137722019755 H-loop/switch region; other site 137722019756 TOBE domain; Region: TOBE_2; pfam08402 137722019757 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 137722019758 hypothetical protein; Provisional; Region: PRK11622 137722019759 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 137722019760 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 137722019761 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 137722019762 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722019763 dimerization interface [polypeptide binding]; other site 137722019764 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722019765 dimer interface [polypeptide binding]; other site 137722019766 putative CheW interface [polypeptide binding]; other site 137722019767 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 137722019768 CheC-like family; Region: CheC; pfam04509 137722019769 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 137722019770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722019771 PAS domain; Region: PAS_9; pfam13426 137722019772 putative active site [active] 137722019773 heme pocket [chemical binding]; other site 137722019774 PAS fold; Region: PAS_4; pfam08448 137722019775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 137722019776 Histidine kinase; Region: HisKA_2; pfam07568 137722019777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722019778 ATP binding site [chemical binding]; other site 137722019779 Mg2+ binding site [ion binding]; other site 137722019780 G-X-G motif; other site 137722019781 Response regulator receiver domain; Region: Response_reg; pfam00072 137722019782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722019783 active site 137722019784 phosphorylation site [posttranslational modification] 137722019785 intermolecular recognition site; other site 137722019786 dimerization interface [polypeptide binding]; other site 137722019787 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 137722019788 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 137722019789 Walker A/P-loop; other site 137722019790 ATP binding site [chemical binding]; other site 137722019791 Q-loop/lid; other site 137722019792 ABC transporter signature motif; other site 137722019793 Walker B; other site 137722019794 D-loop; other site 137722019795 H-loop/switch region; other site 137722019796 hypothetical protein; Provisional; Region: PRK01254 137722019797 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 137722019798 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 137722019799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722019800 Major Facilitator Superfamily; Region: MFS_1; pfam07690 137722019801 putative substrate translocation pore; other site 137722019802 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 137722019803 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 137722019804 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722019805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722019806 non-specific DNA binding site [nucleotide binding]; other site 137722019807 salt bridge; other site 137722019808 sequence-specific DNA binding site [nucleotide binding]; other site 137722019809 Cupin domain; Region: Cupin_2; pfam07883 137722019810 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 137722019811 Amidase; Region: Amidase; pfam01425 137722019812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722019813 D-galactonate transporter; Region: 2A0114; TIGR00893 137722019814 putative substrate translocation pore; other site 137722019815 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 137722019816 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 137722019817 hydroxyglutarate oxidase; Provisional; Region: PRK11728 137722019818 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 137722019819 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 137722019820 Walker A/P-loop; other site 137722019821 ATP binding site [chemical binding]; other site 137722019822 Q-loop/lid; other site 137722019823 ABC transporter signature motif; other site 137722019824 Walker B; other site 137722019825 D-loop; other site 137722019826 H-loop/switch region; other site 137722019827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722019828 dimer interface [polypeptide binding]; other site 137722019829 conserved gate region; other site 137722019830 putative PBP binding loops; other site 137722019831 ABC-ATPase subunit interface; other site 137722019832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722019833 dimer interface [polypeptide binding]; other site 137722019834 conserved gate region; other site 137722019835 putative PBP binding loops; other site 137722019836 ABC-ATPase subunit interface; other site 137722019837 PBP superfamily domain; Region: PBP_like_2; cl17296 137722019838 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 137722019839 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722019840 dimerization interface [polypeptide binding]; other site 137722019841 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722019842 dimer interface [polypeptide binding]; other site 137722019843 putative CheW interface [polypeptide binding]; other site 137722019844 putative glutathione S-transferase; Provisional; Region: PRK10357 137722019845 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 137722019846 putative C-terminal domain interface [polypeptide binding]; other site 137722019847 putative GSH binding site (G-site) [chemical binding]; other site 137722019848 putative dimer interface [polypeptide binding]; other site 137722019849 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 137722019850 dimer interface [polypeptide binding]; other site 137722019851 N-terminal domain interface [polypeptide binding]; other site 137722019852 putative substrate binding pocket (H-site) [chemical binding]; other site 137722019853 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 137722019854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 137722019855 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 137722019856 DsrE/DsrF-like family; Region: DrsE; cl00672 137722019857 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 137722019858 NMT1-like family; Region: NMT1_2; pfam13379 137722019859 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 137722019860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722019861 putative substrate translocation pore; other site 137722019862 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 137722019863 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 137722019864 ligand binding site [chemical binding]; other site 137722019865 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 137722019866 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722019867 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722019868 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 137722019869 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722019870 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 137722019871 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 137722019872 SelR domain; Region: SelR; pfam01641 137722019873 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722019874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722019875 dimer interface [polypeptide binding]; other site 137722019876 phosphorylation site [posttranslational modification] 137722019877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722019878 ATP binding site [chemical binding]; other site 137722019879 Mg2+ binding site [ion binding]; other site 137722019880 G-X-G motif; other site 137722019881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 137722019882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722019883 active site 137722019884 phosphorylation site [posttranslational modification] 137722019885 intermolecular recognition site; other site 137722019886 dimerization interface [polypeptide binding]; other site 137722019887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722019888 DNA binding site [nucleotide binding] 137722019889 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 137722019890 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722019891 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722019892 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 137722019893 H+ Antiporter protein; Region: 2A0121; TIGR00900 137722019894 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 137722019895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722019896 active site 137722019897 phosphorylation site [posttranslational modification] 137722019898 intermolecular recognition site; other site 137722019899 dimerization interface [polypeptide binding]; other site 137722019900 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 137722019901 DNA binding site [nucleotide binding] 137722019902 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 137722019903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722019904 DNA-binding site [nucleotide binding]; DNA binding site 137722019905 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 137722019906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722019907 homodimer interface [polypeptide binding]; other site 137722019908 catalytic residue [active] 137722019909 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722019910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722019911 active site 137722019912 phosphorylation site [posttranslational modification] 137722019913 intermolecular recognition site; other site 137722019914 dimerization interface [polypeptide binding]; other site 137722019915 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722019916 DNA binding residues [nucleotide binding] 137722019917 dimerization interface [polypeptide binding]; other site 137722019918 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 137722019919 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 137722019920 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 137722019921 ligand binding site [chemical binding]; other site 137722019922 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 137722019923 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 137722019924 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 137722019925 dimerization interface [polypeptide binding]; other site 137722019926 ligand binding site [chemical binding]; other site 137722019927 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 137722019928 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 137722019929 Walker A/P-loop; other site 137722019930 ATP binding site [chemical binding]; other site 137722019931 Q-loop/lid; other site 137722019932 ABC transporter signature motif; other site 137722019933 Walker B; other site 137722019934 D-loop; other site 137722019935 H-loop/switch region; other site 137722019936 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 137722019937 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 137722019938 Walker A/P-loop; other site 137722019939 ATP binding site [chemical binding]; other site 137722019940 Q-loop/lid; other site 137722019941 ABC transporter signature motif; other site 137722019942 Walker B; other site 137722019943 D-loop; other site 137722019944 H-loop/switch region; other site 137722019945 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722019946 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 137722019947 TM-ABC transporter signature motif; other site 137722019948 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722019949 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 137722019950 TM-ABC transporter signature motif; other site 137722019951 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722019952 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722019953 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722019954 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722019955 fructokinase; Reviewed; Region: PRK09557 137722019956 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 137722019957 nucleotide binding site [chemical binding]; other site 137722019958 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 137722019959 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 137722019960 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 137722019961 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 137722019962 Ligand binding site; other site 137722019963 Putative Catalytic site; other site 137722019964 DXD motif; other site 137722019965 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 137722019966 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 137722019967 protein binding site [polypeptide binding]; other site 137722019968 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 137722019969 protein binding site [polypeptide binding]; other site 137722019970 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 137722019971 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 137722019972 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722019973 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 137722019974 dimerization interface [polypeptide binding]; other site 137722019975 PAS fold; Region: PAS_7; pfam12860 137722019976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722019977 PAS fold; Region: PAS_3; pfam08447 137722019978 putative active site [active] 137722019979 heme pocket [chemical binding]; other site 137722019980 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722019981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 137722019982 dimer interface [polypeptide binding]; other site 137722019983 phosphorylation site [posttranslational modification] 137722019984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722019985 ATP binding site [chemical binding]; other site 137722019986 Mg2+ binding site [ion binding]; other site 137722019987 G-X-G motif; other site 137722019988 Predicted membrane protein [Function unknown]; Region: COG1238 137722019989 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 137722019990 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 137722019991 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 137722019992 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 137722019993 active site 137722019994 Acyltransferase family; Region: Acyl_transf_3; pfam01757 137722019995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722019996 S-adenosylmethionine binding site [chemical binding]; other site 137722019997 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 137722019998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722019999 dimer interface [polypeptide binding]; other site 137722020000 phosphorylation site [posttranslational modification] 137722020001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722020002 ATP binding site [chemical binding]; other site 137722020003 Mg2+ binding site [ion binding]; other site 137722020004 G-X-G motif; other site 137722020005 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 137722020006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722020007 active site 137722020008 phosphorylation site [posttranslational modification] 137722020009 intermolecular recognition site; other site 137722020010 dimerization interface [polypeptide binding]; other site 137722020011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722020012 Walker A motif; other site 137722020013 ATP binding site [chemical binding]; other site 137722020014 Walker B motif; other site 137722020015 arginine finger; other site 137722020016 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722020017 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 137722020018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722020019 dimerization interface [polypeptide binding]; other site 137722020020 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722020021 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722020022 dimer interface [polypeptide binding]; other site 137722020023 putative CheW interface [polypeptide binding]; other site 137722020024 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 137722020025 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 137722020026 DNA binding residues [nucleotide binding] 137722020027 putative dimer interface [polypeptide binding]; other site 137722020028 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 137722020029 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 137722020030 dimer interface [polypeptide binding]; other site 137722020031 acyl-activating enzyme (AAE) consensus motif; other site 137722020032 putative active site [active] 137722020033 AMP binding site [chemical binding]; other site 137722020034 putative CoA binding site [chemical binding]; other site 137722020035 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 137722020036 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 137722020037 N- and C-terminal domain interface [polypeptide binding]; other site 137722020038 active site 137722020039 MgATP binding site [chemical binding]; other site 137722020040 catalytic site [active] 137722020041 metal binding site [ion binding]; metal-binding site 137722020042 glycerol binding site [chemical binding]; other site 137722020043 homotetramer interface [polypeptide binding]; other site 137722020044 homodimer interface [polypeptide binding]; other site 137722020045 FBP binding site [chemical binding]; other site 137722020046 protein IIAGlc interface [polypeptide binding]; other site 137722020047 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 137722020048 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 137722020049 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 137722020050 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 137722020051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722020052 dimer interface [polypeptide binding]; other site 137722020053 conserved gate region; other site 137722020054 putative PBP binding loops; other site 137722020055 ABC-ATPase subunit interface; other site 137722020056 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 137722020057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722020058 dimer interface [polypeptide binding]; other site 137722020059 conserved gate region; other site 137722020060 putative PBP binding loops; other site 137722020061 ABC-ATPase subunit interface; other site 137722020062 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 137722020063 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 137722020064 Walker A/P-loop; other site 137722020065 ATP binding site [chemical binding]; other site 137722020066 Q-loop/lid; other site 137722020067 ABC transporter signature motif; other site 137722020068 Walker B; other site 137722020069 D-loop; other site 137722020070 H-loop/switch region; other site 137722020071 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 137722020072 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 137722020073 Walker A/P-loop; other site 137722020074 ATP binding site [chemical binding]; other site 137722020075 Q-loop/lid; other site 137722020076 ABC transporter signature motif; other site 137722020077 Walker B; other site 137722020078 D-loop; other site 137722020079 H-loop/switch region; other site 137722020080 TOBE domain; Region: TOBE_2; pfam08402 137722020081 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 137722020082 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722020083 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722020084 dimer interface [polypeptide binding]; other site 137722020085 putative CheW interface [polypeptide binding]; other site 137722020086 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 137722020087 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 137722020088 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 137722020089 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 137722020090 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 137722020091 active site 137722020092 Hemerythrin-like domain; Region: Hr-like; cd12108 137722020093 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 137722020094 Ligand Binding Site [chemical binding]; other site 137722020095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 137722020096 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 137722020097 substrate binding site [chemical binding]; other site 137722020098 AAA domain; Region: AAA_33; pfam13671 137722020099 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 137722020100 Flagellar protein FlaF; Region: FlaF; cl11454 137722020101 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 137722020102 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 137722020103 EamA-like transporter family; Region: EamA; pfam00892 137722020104 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 137722020105 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 137722020106 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 137722020107 PRC-barrel domain; Region: PRC; pfam05239 137722020108 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 137722020109 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 137722020110 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 137722020111 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 137722020112 active site 137722020113 SUMO-1 interface [polypeptide binding]; other site 137722020114 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 137722020115 catalytic core [active] 137722020116 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 137722020117 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 137722020118 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 137722020119 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 137722020120 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 137722020121 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 137722020122 catalytic loop [active] 137722020123 iron binding site [ion binding]; other site 137722020124 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 137722020125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722020126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722020127 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 137722020128 putative substrate binding pocket [chemical binding]; other site 137722020129 putative dimerization interface [polypeptide binding]; other site 137722020130 Ferritin-like; Region: Ferritin-like; pfam12902 137722020131 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722020132 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722020133 Walker A/P-loop; other site 137722020134 ATP binding site [chemical binding]; other site 137722020135 Q-loop/lid; other site 137722020136 ABC transporter signature motif; other site 137722020137 Walker B; other site 137722020138 D-loop; other site 137722020139 H-loop/switch region; other site 137722020140 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722020141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722020142 putative PBP binding loops; other site 137722020143 dimer interface [polypeptide binding]; other site 137722020144 ABC-ATPase subunit interface; other site 137722020145 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 137722020146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722020147 membrane-bound complex binding site; other site 137722020148 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 137722020149 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 137722020150 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 137722020151 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 137722020152 Transcriptional regulators [Transcription]; Region: FadR; COG2186 137722020153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722020154 DNA-binding site [nucleotide binding]; DNA binding site 137722020155 FCD domain; Region: FCD; pfam07729 137722020156 mannonate dehydratase; Provisional; Region: PRK03906 137722020157 mannonate dehydratase; Region: uxuA; TIGR00695 137722020158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722020159 NAD(P) binding site [chemical binding]; other site 137722020160 short chain dehydrogenase; Provisional; Region: PRK07577 137722020161 active site 137722020162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722020163 D-galactonate transporter; Region: 2A0114; TIGR00893 137722020164 putative substrate translocation pore; other site 137722020165 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 137722020166 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 137722020167 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 137722020168 putative active site [active] 137722020169 putative catalytic site [active] 137722020170 Transcriptional regulators [Transcription]; Region: PurR; COG1609 137722020171 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 137722020172 DNA binding site [nucleotide binding] 137722020173 domain linker motif; other site 137722020174 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 137722020175 dimerization interface [polypeptide binding]; other site 137722020176 ligand binding site [chemical binding]; other site 137722020177 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 137722020178 TrkA-N domain; Region: TrkA_N; pfam02254 137722020179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722020180 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722020181 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 137722020182 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722020183 Src Homology 3 domain superfamily; Region: SH3; cl17036 137722020184 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 137722020185 NlpC/P60 family; Region: NLPC_P60; cl17555 137722020186 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 137722020187 active site 137722020188 SAM binding site [chemical binding]; other site 137722020189 homodimer interface [polypeptide binding]; other site 137722020190 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 137722020191 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 137722020192 [4Fe-4S] binding site [ion binding]; other site 137722020193 molybdopterin cofactor binding site; other site 137722020194 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 137722020195 molybdopterin cofactor binding site; other site 137722020196 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 137722020197 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 137722020198 [2Fe-2S] cluster binding site [ion binding]; other site 137722020199 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 137722020200 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 137722020201 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 137722020202 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 137722020203 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 137722020204 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 137722020205 NMT1-like family; Region: NMT1_2; pfam13379 137722020206 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 137722020207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 137722020208 dimer interface [polypeptide binding]; other site 137722020209 conserved gate region; other site 137722020210 putative PBP binding loops; other site 137722020211 ABC-ATPase subunit interface; other site 137722020212 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 137722020213 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722020214 Walker A/P-loop; other site 137722020215 ATP binding site [chemical binding]; other site 137722020216 Q-loop/lid; other site 137722020217 ABC transporter signature motif; other site 137722020218 Walker B; other site 137722020219 D-loop; other site 137722020220 H-loop/switch region; other site 137722020221 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 137722020222 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 137722020223 Walker A/P-loop; other site 137722020224 ATP binding site [chemical binding]; other site 137722020225 Q-loop/lid; other site 137722020226 ABC transporter signature motif; other site 137722020227 Walker B; other site 137722020228 D-loop; other site 137722020229 H-loop/switch region; other site 137722020230 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 137722020231 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 137722020232 active site 137722020233 catalytic tetrad [active] 137722020234 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 137722020235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 137722020236 ATP binding site [chemical binding]; other site 137722020237 putative Mg++ binding site [ion binding]; other site 137722020238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 137722020239 nucleotide binding region [chemical binding]; other site 137722020240 ATP-binding site [chemical binding]; other site 137722020241 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 137722020242 active site 137722020243 catalytic residues [active] 137722020244 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722020245 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 137722020246 TM-ABC transporter signature motif; other site 137722020247 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722020248 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 137722020249 TM-ABC transporter signature motif; other site 137722020250 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 137722020251 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 137722020252 Walker A/P-loop; other site 137722020253 ATP binding site [chemical binding]; other site 137722020254 Q-loop/lid; other site 137722020255 ABC transporter signature motif; other site 137722020256 Walker B; other site 137722020257 D-loop; other site 137722020258 H-loop/switch region; other site 137722020259 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 137722020260 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 137722020261 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 137722020262 putative ligand binding site [chemical binding]; other site 137722020263 Gram-negative porin; Region: Porin_4; pfam13609 137722020264 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 137722020265 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 137722020266 dimer interface [polypeptide binding]; other site 137722020267 NADP binding site [chemical binding]; other site 137722020268 catalytic residues [active] 137722020269 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 137722020270 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 137722020271 inhibitor site; inhibition site 137722020272 active site 137722020273 dimer interface [polypeptide binding]; other site 137722020274 catalytic residue [active] 137722020275 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 137722020276 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 137722020277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722020278 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 137722020279 putative dimerization interface [polypeptide binding]; other site 137722020280 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 137722020281 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 137722020282 putative ligand binding site [chemical binding]; other site 137722020283 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 137722020284 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 137722020285 Walker A/P-loop; other site 137722020286 ATP binding site [chemical binding]; other site 137722020287 Q-loop/lid; other site 137722020288 ABC transporter signature motif; other site 137722020289 Walker B; other site 137722020290 D-loop; other site 137722020291 H-loop/switch region; other site 137722020292 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 137722020293 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722020294 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 137722020295 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 137722020296 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 137722020297 TM-ABC transporter signature motif; other site 137722020298 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 137722020299 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 137722020300 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 137722020301 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722020302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722020303 dimer interface [polypeptide binding]; other site 137722020304 phosphorylation site [posttranslational modification] 137722020305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722020306 ATP binding site [chemical binding]; other site 137722020307 Mg2+ binding site [ion binding]; other site 137722020308 G-X-G motif; other site 137722020309 Response regulator receiver domain; Region: Response_reg; pfam00072 137722020310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722020311 active site 137722020312 phosphorylation site [posttranslational modification] 137722020313 intermolecular recognition site; other site 137722020314 dimerization interface [polypeptide binding]; other site 137722020315 Hpt domain; Region: Hpt; pfam01627 137722020316 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 137722020317 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 137722020318 substrate binding pocket [chemical binding]; other site 137722020319 membrane-bound complex binding site; other site 137722020320 hinge residues; other site 137722020321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 137722020322 putative substrate translocation pore; other site 137722020323 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 137722020324 Na binding site [ion binding]; other site 137722020325 PAS fold; Region: PAS_7; pfam12860 137722020326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 137722020327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722020328 dimer interface [polypeptide binding]; other site 137722020329 phosphorylation site [posttranslational modification] 137722020330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722020331 ATP binding site [chemical binding]; other site 137722020332 Mg2+ binding site [ion binding]; other site 137722020333 G-X-G motif; other site 137722020334 Response regulator receiver domain; Region: Response_reg; pfam00072 137722020335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722020336 active site 137722020337 phosphorylation site [posttranslational modification] 137722020338 intermolecular recognition site; other site 137722020339 dimerization interface [polypeptide binding]; other site 137722020340 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255 137722020341 putative nucleotide binding site [chemical binding]; other site 137722020342 putative substrate binding site [chemical binding]; other site 137722020343 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 137722020344 nucleotide binding site [chemical binding]; other site 137722020345 substrate binding site [chemical binding]; other site 137722020346 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 137722020347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722020348 active site 137722020349 phosphorylation site [posttranslational modification] 137722020350 intermolecular recognition site; other site 137722020351 dimerization interface [polypeptide binding]; other site 137722020352 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 137722020353 DNA binding residues [nucleotide binding] 137722020354 dimerization interface [polypeptide binding]; other site 137722020355 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 137722020356 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 137722020357 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 137722020358 dimer interface [polypeptide binding]; other site 137722020359 active site 137722020360 citrylCoA binding site [chemical binding]; other site 137722020361 NADH binding [chemical binding]; other site 137722020362 cationic pore residues; other site 137722020363 oxalacetate/citrate binding site [chemical binding]; other site 137722020364 coenzyme A binding site [chemical binding]; other site 137722020365 catalytic triad [active] 137722020366 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 137722020367 GAF domain; Region: GAF; pfam01590 137722020368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722020369 PAS fold; Region: PAS_3; pfam08447 137722020370 putative active site [active] 137722020371 heme pocket [chemical binding]; other site 137722020372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722020373 PAS fold; Region: PAS_3; pfam08447 137722020374 putative active site [active] 137722020375 heme pocket [chemical binding]; other site 137722020376 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722020377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722020378 dimer interface [polypeptide binding]; other site 137722020379 phosphorylation site [posttranslational modification] 137722020380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722020381 ATP binding site [chemical binding]; other site 137722020382 Mg2+ binding site [ion binding]; other site 137722020383 G-X-G motif; other site 137722020384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722020385 active site 137722020386 phosphorylation site [posttranslational modification] 137722020387 intermolecular recognition site; other site 137722020388 Response regulator receiver domain; Region: Response_reg; pfam00072 137722020389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722020390 active site 137722020391 phosphorylation site [posttranslational modification] 137722020392 intermolecular recognition site; other site 137722020393 dimerization interface [polypeptide binding]; other site 137722020394 Hpt domain; Region: Hpt; pfam01627 137722020395 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 137722020396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722020397 active site 137722020398 phosphorylation site [posttranslational modification] 137722020399 intermolecular recognition site; other site 137722020400 dimerization interface [polypeptide binding]; other site 137722020401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722020402 Walker A motif; other site 137722020403 ATP binding site [chemical binding]; other site 137722020404 Walker B motif; other site 137722020405 arginine finger; other site 137722020406 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722020407 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 137722020408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 137722020409 DNA-binding site [nucleotide binding]; DNA binding site 137722020410 FCD domain; Region: FCD; pfam07729 137722020411 L-lactate permease; Region: Lactate_perm; cl00701 137722020412 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 137722020413 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 137722020414 FAD binding domain; Region: FAD_binding_4; pfam01565 137722020415 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 137722020416 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 137722020417 Cysteine-rich domain; Region: CCG; pfam02754 137722020418 Cysteine-rich domain; Region: CCG; pfam02754 137722020419 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 137722020420 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 137722020421 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 137722020422 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 137722020423 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 137722020424 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 137722020425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 137722020426 hydroxyglutarate oxidase; Provisional; Region: PRK11728 137722020427 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 137722020428 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 137722020429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722020430 Walker A motif; other site 137722020431 ATP binding site [chemical binding]; other site 137722020432 Walker B motif; other site 137722020433 arginine finger; other site 137722020434 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 137722020435 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 137722020436 PAS fold; Region: PAS_4; pfam08448 137722020437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 137722020438 putative active site [active] 137722020439 heme pocket [chemical binding]; other site 137722020440 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 137722020441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722020442 Walker A motif; other site 137722020443 ATP binding site [chemical binding]; other site 137722020444 Walker B motif; other site 137722020445 arginine finger; other site 137722020446 General stress protein [General function prediction only]; Region: GsiB; COG3729 137722020447 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 137722020448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 137722020449 dimer interface [polypeptide binding]; other site 137722020450 phosphorylation site [posttranslational modification] 137722020451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722020452 ATP binding site [chemical binding]; other site 137722020453 Mg2+ binding site [ion binding]; other site 137722020454 G-X-G motif; other site 137722020455 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 137722020456 DctM-like transporters; Region: DctM; pfam06808 137722020457 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 137722020458 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 137722020459 GAF domain; Region: GAF; pfam01590 137722020460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722020461 Walker B motif; other site 137722020462 arginine finger; other site 137722020463 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 137722020464 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 137722020465 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 137722020466 heme-binding site [chemical binding]; other site 137722020467 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 137722020468 FAD binding pocket [chemical binding]; other site 137722020469 FAD binding motif [chemical binding]; other site 137722020470 phosphate binding motif [ion binding]; other site 137722020471 beta-alpha-beta structure motif; other site 137722020472 NAD binding pocket [chemical binding]; other site 137722020473 Heme binding pocket [chemical binding]; other site 137722020474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 137722020475 dimerization interface [polypeptide binding]; other site 137722020476 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 137722020477 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 137722020478 dimer interface [polypeptide binding]; other site 137722020479 putative CheW interface [polypeptide binding]; other site 137722020480 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 137722020481 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 137722020482 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 137722020483 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 137722020484 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 137722020485 putative active site [active] 137722020486 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 137722020487 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 137722020488 active site 137722020489 intersubunit interface [polypeptide binding]; other site 137722020490 catalytic residue [active] 137722020491 conserved hypothetical protein; Region: MG423; TIGR00649 137722020492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 137722020493 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 137722020494 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 137722020495 Carbon starvation protein CstA; Region: CstA; pfam02554 137722020496 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 137722020497 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 137722020498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 137722020499 active site 137722020500 phosphorylation site [posttranslational modification] 137722020501 intermolecular recognition site; other site 137722020502 dimerization interface [polypeptide binding]; other site 137722020503 LytTr DNA-binding domain; Region: LytTR; pfam04397 137722020504 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 137722020505 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 137722020506 Histidine kinase; Region: His_kinase; pfam06580 137722020507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 137722020508 ATP binding site [chemical binding]; other site 137722020509 Mg2+ binding site [ion binding]; other site 137722020510 G-X-G motif; other site 137722020511 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 137722020512 NodB motif; other site 137722020513 active site 137722020514 catalytic site [active] 137722020515 metal binding site [ion binding]; metal-binding site 137722020516 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 137722020517 malonyl-CoA synthase; Validated; Region: PRK07514 137722020518 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 137722020519 acyl-activating enzyme (AAE) consensus motif; other site 137722020520 active site 137722020521 AMP binding site [chemical binding]; other site 137722020522 CoA binding site [chemical binding]; other site 137722020523 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 137722020524 heme binding pocket [chemical binding]; other site 137722020525 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 137722020526 Transcriptional regulator [Transcription]; Region: LysR; COG0583 137722020527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 137722020528 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 137722020529 putative effector binding pocket; other site 137722020530 putative dimerization interface [polypeptide binding]; other site 137722020531 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 137722020532 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 137722020533 NAD binding site [chemical binding]; other site 137722020534 catalytic residues [active] 137722020535 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 137722020536 ParB-like nuclease domain; Region: ParB; smart00470 137722020537 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 137722020538 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722020539 P-loop; other site 137722020540 Magnesium ion binding site [ion binding]; other site 137722020541 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722020542 Magnesium ion binding site [ion binding]; other site 137722020543 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 137722020544 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 137722020545 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 137722020546 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 137722020547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722020548 Walker A/P-loop; other site 137722020549 ATP binding site [chemical binding]; other site 137722020550 Q-loop/lid; other site 137722020551 ABC transporter signature motif; other site 137722020552 Walker B; other site 137722020553 D-loop; other site 137722020554 H-loop/switch region; other site 137722020555 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722020556 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 137722020557 putative ADP-binding pocket [chemical binding]; other site 137722020558 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 137722020559 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 137722020560 NAD(P) binding site [chemical binding]; other site 137722020561 homodimer interface [polypeptide binding]; other site 137722020562 substrate binding site [chemical binding]; other site 137722020563 active site 137722020564 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 137722020565 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 137722020566 inhibitor-cofactor binding pocket; inhibition site 137722020567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 137722020568 catalytic residue [active] 137722020569 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 137722020570 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 137722020571 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 137722020572 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 137722020573 Uncharacterized conserved protein [Function unknown]; Region: COG1739 137722020574 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 137722020575 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 137722020576 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 137722020577 Peptidase family M23; Region: Peptidase_M23; pfam01551 137722020578 Right handed beta helix region; Region: Beta_helix; pfam13229 137722020579 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722020580 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722020581 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722020582 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722020583 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 137722020584 Methyltransferase domain; Region: Methyltransf_23; pfam13489 137722020585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722020586 S-adenosylmethionine binding site [chemical binding]; other site 137722020587 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 137722020588 Ligand binding site; other site 137722020589 Putative Catalytic site; other site 137722020590 DXD motif; other site 137722020591 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 137722020592 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 137722020593 dimer interface [polypeptide binding]; other site 137722020594 ADP-ribose binding site [chemical binding]; other site 137722020595 active site 137722020596 nudix motif; other site 137722020597 metal binding site [ion binding]; metal-binding site 137722020598 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 137722020599 putative active site [active] 137722020600 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 137722020601 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 137722020602 PemK-like protein; Region: PemK; pfam02452 137722020603 BNR repeat-like domain; Region: BNR_2; pfam13088 137722020604 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 137722020605 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 137722020606 iron-sulfur cluster [ion binding]; other site 137722020607 [2Fe-2S] cluster binding site [ion binding]; other site 137722020608 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 137722020609 alpha subunit interface [polypeptide binding]; other site 137722020610 active site 137722020611 substrate binding site [chemical binding]; other site 137722020612 Fe binding site [ion binding]; other site 137722020613 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 137722020614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 137722020615 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 137722020616 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 137722020617 classical (c) SDRs; Region: SDR_c; cd05233 137722020618 NAD(P) binding site [chemical binding]; other site 137722020619 active site 137722020620 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 137722020621 HipA N-terminal domain; Region: Couple_hipA; cl11853 137722020622 HipA-like N-terminal domain; Region: HipA_N; pfam07805 137722020623 HipA-like C-terminal domain; Region: HipA_C; pfam07804 137722020624 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 137722020625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 137722020626 non-specific DNA binding site [nucleotide binding]; other site 137722020627 salt bridge; other site 137722020628 sequence-specific DNA binding site [nucleotide binding]; other site 137722020629 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 137722020630 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 137722020631 dimer interface [polypeptide binding]; other site 137722020632 active site 137722020633 CoA binding pocket [chemical binding]; other site 137722020634 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 137722020635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722020636 TPR motif; other site 137722020637 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 137722020638 binding surface 137722020639 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722020640 binding surface 137722020641 TPR motif; other site 137722020642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722020643 binding surface 137722020644 TPR motif; other site 137722020645 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 137722020646 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 137722020647 FeS/SAM binding site; other site 137722020648 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 137722020649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722020650 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 137722020651 binding surface 137722020652 TPR motif; other site 137722020653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722020654 TPR motif; other site 137722020655 binding surface 137722020656 TPR repeat; Region: TPR_11; pfam13414 137722020657 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 137722020658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 137722020659 Homeodomain-like domain; Region: HTH_32; pfam13565 137722020660 Integrase core domain; Region: rve; pfam00665 137722020661 Integrase core domain; Region: rve_3; pfam13683 137722020662 Homeodomain-like domain; Region: HTH_23; cl17451 137722020663 Methyltransferase domain; Region: Methyltransf_18; pfam12847 137722020664 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722020665 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722020666 Methyltransferase domain; Region: Methyltransf_24; pfam13578 137722020667 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 137722020668 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 137722020669 active site 137722020670 catalytic tetrad [active] 137722020671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722020672 NAD(P) binding site [chemical binding]; other site 137722020673 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 137722020674 active site 137722020675 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 137722020676 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 137722020677 PYR/PP interface [polypeptide binding]; other site 137722020678 dimer interface [polypeptide binding]; other site 137722020679 TPP binding site [chemical binding]; other site 137722020680 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 137722020681 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 137722020682 TPP-binding site [chemical binding]; other site 137722020683 dimer interface [polypeptide binding]; other site 137722020684 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 137722020685 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 137722020686 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 137722020687 dimer interface [polypeptide binding]; other site 137722020688 ADP-ribose binding site [chemical binding]; other site 137722020689 active site 137722020690 nudix motif; other site 137722020691 metal binding site [ion binding]; metal-binding site 137722020692 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 137722020693 extended (e) SDRs; Region: SDR_e; cd08946 137722020694 NAD(P) binding site [chemical binding]; other site 137722020695 active site 137722020696 substrate binding site [chemical binding]; other site 137722020697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722020698 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 137722020699 Transposase domain (DUF772); Region: DUF772; pfam05598 137722020700 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722020701 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 137722020702 Integrase core domain; Region: rve; pfam00665 137722020703 HTH-like domain; Region: HTH_21; pfam13276 137722020704 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 137722020705 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722020706 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722020707 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722020708 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722020709 Integrase core domain; Region: rve; pfam00665 137722020710 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722020711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722020712 Walker A motif; other site 137722020713 ATP binding site [chemical binding]; other site 137722020714 Transposase; Region: DEDD_Tnp_IS110; pfam01548 137722020715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 137722020716 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 137722020717 Transposase; Region: HTH_Tnp_1; cl17663 137722020718 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722020719 High-affinity nickel-transport protein; Region: NicO; cl00964 137722020720 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 137722020721 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 137722020722 Substrate binding site; other site 137722020723 Mg++ binding site; other site 137722020724 metal-binding site 137722020725 Mg++ binding site; other site 137722020726 metal-binding site 137722020727 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 137722020728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722020729 motif I; other site 137722020730 motif II; other site 137722020731 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722020732 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722020733 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722020734 Transposase domain (DUF772); Region: DUF772; pfam05598 137722020735 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722020736 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 137722020737 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 137722020738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 137722020739 Integrase core domain; Region: rve; pfam00665 137722020740 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722020741 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 137722020742 catalytic residues [active] 137722020743 catalytic nucleophile [active] 137722020744 Presynaptic Site I dimer interface [polypeptide binding]; other site 137722020745 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 137722020746 Synaptic Flat tetramer interface [polypeptide binding]; other site 137722020747 Synaptic Site I dimer interface [polypeptide binding]; other site 137722020748 DNA binding site [nucleotide binding] 137722020749 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 137722020750 DNA-binding interface [nucleotide binding]; DNA binding site 137722020751 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 137722020752 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 137722020753 oligomeric interface; other site 137722020754 putative active site [active] 137722020755 homodimer interface [polypeptide binding]; other site 137722020756 Cytochrome P450; Region: p450; pfam00067 137722020757 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 137722020758 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 137722020759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722020760 S-adenosylmethionine binding site [chemical binding]; other site 137722020761 Condensation domain; Region: Condensation; pfam00668 137722020762 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 137722020763 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 137722020764 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 137722020765 acyl-activating enzyme (AAE) consensus motif; other site 137722020766 AMP binding site [chemical binding]; other site 137722020767 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722020768 thioester reductase domain; Region: Thioester-redct; TIGR01746 137722020769 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 137722020770 putative NAD(P) binding site [chemical binding]; other site 137722020771 active site 137722020772 putative substrate binding site [chemical binding]; other site 137722020773 Condensation domain; Region: Condensation; pfam00668 137722020774 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 137722020775 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 137722020776 acyl-activating enzyme (AAE) consensus motif; other site 137722020777 AMP binding site [chemical binding]; other site 137722020778 active site 137722020779 CoA binding site [chemical binding]; other site 137722020780 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722020781 acyl-CoA synthetase; Validated; Region: PRK05850 137722020782 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 137722020783 acyl-activating enzyme (AAE) consensus motif; other site 137722020784 active site 137722020785 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722020786 Condensation domain; Region: Condensation; pfam00668 137722020787 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 137722020788 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 137722020789 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 137722020790 acyl-activating enzyme (AAE) consensus motif; other site 137722020791 AMP binding site [chemical binding]; other site 137722020792 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722020793 Condensation domain; Region: Condensation; pfam00668 137722020794 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 137722020795 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 137722020796 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 137722020797 acyl-activating enzyme (AAE) consensus motif; other site 137722020798 AMP binding site [chemical binding]; other site 137722020799 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 137722020800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722020801 S-adenosylmethionine binding site [chemical binding]; other site 137722020802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 137722020803 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 137722020804 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 137722020805 folate binding site [chemical binding]; other site 137722020806 NADP+ binding site [chemical binding]; other site 137722020807 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 137722020808 Peptidase family M28; Region: Peptidase_M28; pfam04389 137722020809 metal binding site [ion binding]; metal-binding site 137722020810 MbtH-like protein; Region: MbtH; cl01279 137722020811 Transposase domain (DUF772); Region: DUF772; pfam05598 137722020812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 137722020813 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722020814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 137722020815 Helix-turn-helix domain; Region: HTH_28; pfam13518 137722020816 Winged helix-turn helix; Region: HTH_29; pfam13551 137722020817 Winged helix-turn helix; Region: HTH_33; pfam13592 137722020818 Transposase, Mutator family; Region: Transposase_mut; pfam00872 137722020819 MULE transposase domain; Region: MULE; pfam10551 137722020820 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722020821 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 137722020822 Transposase; Region: HTH_Tnp_1; cl17663 137722020823 putative transposase OrfB; Reviewed; Region: PHA02517 137722020824 HTH-like domain; Region: HTH_21; pfam13276 137722020825 Integrase core domain; Region: rve; pfam00665 137722020826 Integrase core domain; Region: rve_3; pfam13683 137722020827 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 137722020828 Integrase core domain; Region: rve; pfam00665 137722020829 multiple promoter invertase; Provisional; Region: mpi; PRK13413 137722020830 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 137722020831 catalytic residues [active] 137722020832 catalytic nucleophile [active] 137722020833 Presynaptic Site I dimer interface [polypeptide binding]; other site 137722020834 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 137722020835 Synaptic Flat tetramer interface [polypeptide binding]; other site 137722020836 Synaptic Site I dimer interface [polypeptide binding]; other site 137722020837 DNA binding site [nucleotide binding] 137722020838 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 137722020839 DNA-binding interface [nucleotide binding]; DNA binding site 137722020840 putative addiction module antidote; Region: doc_partner; TIGR02609 137722020841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 137722020842 Homeodomain-like domain; Region: HTH_32; pfam13565 137722020843 DDE superfamily endonuclease; Region: DDE_3; pfam13358 137722020844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 137722020845 Fic/DOC family; Region: Fic; cl00960 137722020846 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722020847 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722020848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722020849 Integrase core domain; Region: rve; pfam00665 137722020850 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722020851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722020852 Walker A motif; other site 137722020853 ATP binding site [chemical binding]; other site 137722020854 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722020855 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 137722020856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722020857 binding surface 137722020858 TPR motif; other site 137722020859 TPR repeat; Region: TPR_11; pfam13414 137722020860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722020861 TPR motif; other site 137722020862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722020863 TPR motif; other site 137722020864 binding surface 137722020865 TPR repeat; Region: TPR_11; pfam13414 137722020866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722020867 binding surface 137722020868 TPR motif; other site 137722020869 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722020870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722020871 TPR motif; other site 137722020872 TPR repeat; Region: TPR_11; pfam13414 137722020873 binding surface 137722020874 TPR repeat; Region: TPR_11; pfam13414 137722020875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722020876 binding surface 137722020877 TPR motif; other site 137722020878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722020879 Tetratricopeptide repeat; Region: TPR_12; pfam13424 137722020880 binding surface 137722020881 TPR motif; other site 137722020882 TPR repeat; Region: TPR_11; pfam13414 137722020883 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 137722020884 GDP-Fucose binding site [chemical binding]; other site 137722020885 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 137722020886 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 137722020887 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 137722020888 Walker A/P-loop; other site 137722020889 ATP binding site [chemical binding]; other site 137722020890 Q-loop/lid; other site 137722020891 ABC transporter signature motif; other site 137722020892 Walker B; other site 137722020893 D-loop; other site 137722020894 H-loop/switch region; other site 137722020895 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 137722020896 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 137722020897 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 137722020898 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 137722020899 NADP-binding site; other site 137722020900 homotetramer interface [polypeptide binding]; other site 137722020901 substrate binding site [chemical binding]; other site 137722020902 homodimer interface [polypeptide binding]; other site 137722020903 active site 137722020904 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 137722020905 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 137722020906 NADP-binding site; other site 137722020907 homotetramer interface [polypeptide binding]; other site 137722020908 substrate binding site [chemical binding]; other site 137722020909 homodimer interface [polypeptide binding]; other site 137722020910 active site 137722020911 Uncharacterized conserved protein [Function unknown]; Region: COG1262 137722020912 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 137722020913 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 137722020914 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 137722020915 Methyltransferase domain; Region: Methyltransf_23; pfam13489 137722020916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722020917 S-adenosylmethionine binding site [chemical binding]; other site 137722020918 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722020919 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 137722020920 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 137722020921 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 137722020922 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 137722020923 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 137722020924 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722020925 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 137722020926 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 137722020927 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 137722020928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722020929 NAD(P) binding site [chemical binding]; other site 137722020930 active site 137722020931 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722020932 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 137722020933 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 137722020934 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 137722020935 active site 137722020936 putative substrate binding region [chemical binding]; other site 137722020937 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 137722020938 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722020939 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 137722020940 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 137722020941 Active Sites [active] 137722020942 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 137722020943 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 137722020944 CysD dimerization site [polypeptide binding]; other site 137722020945 G1 box; other site 137722020946 putative GEF interaction site [polypeptide binding]; other site 137722020947 GTP/Mg2+ binding site [chemical binding]; other site 137722020948 Switch I region; other site 137722020949 G2 box; other site 137722020950 G3 box; other site 137722020951 Switch II region; other site 137722020952 G4 box; other site 137722020953 G5 box; other site 137722020954 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 137722020955 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 137722020956 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 137722020957 ligand-binding site [chemical binding]; other site 137722020958 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 137722020959 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 137722020960 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 137722020961 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 137722020962 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 137722020963 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 137722020964 translation initiation factor IF-3; Region: infC; TIGR00168 137722020965 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 137722020966 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 137722020967 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 137722020968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 137722020969 active site 137722020970 motif I; other site 137722020971 motif II; other site 137722020972 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 137722020973 Phage Tail Collar Domain; Region: Collar; pfam07484 137722020974 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 137722020975 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 137722020976 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 137722020977 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 137722020978 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 137722020979 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 137722020980 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 137722020981 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 137722020982 Outer membrane efflux protein; Region: OEP; pfam02321 137722020983 Outer membrane efflux protein; Region: OEP; pfam02321 137722020984 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722020985 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722020986 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722020987 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722020988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722020989 Transposase; Region: HTH_Tnp_1; pfam01527 137722020990 Integrase core domain; Region: rve; pfam00665 137722020991 Integrase core domain; Region: rve_2; pfam13333 137722020992 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 137722020993 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722020994 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722020995 Transposase [DNA replication, recombination, and repair]; Region: COG5433 137722020996 Methyltransferase domain; Region: Methyltransf_23; pfam13489 137722020997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722020998 S-adenosylmethionine binding site [chemical binding]; other site 137722020999 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 137722021000 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 137722021001 substrate binding site; other site 137722021002 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 137722021003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722021004 NAD(P) binding site [chemical binding]; other site 137722021005 active site 137722021006 WxcM-like, C-terminal; Region: FdtA; pfam05523 137722021007 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 137722021008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 137722021009 NAD(P) binding site [chemical binding]; other site 137722021010 active site 137722021011 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 137722021012 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 137722021013 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 137722021014 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 137722021015 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 137722021016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722021017 Transposase; Region: HTH_Tnp_1; pfam01527 137722021018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722021019 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722021020 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 137722021021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 137722021022 Walker A motif; other site 137722021023 ATP binding site [chemical binding]; other site 137722021024 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 137722021025 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 137722021026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 137722021027 Integrase core domain; Region: rve; pfam00665 137722021028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722021029 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 137722021030 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722021031 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 137722021032 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 137722021033 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 137722021034 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 137722021035 catalytic residues [active] 137722021036 catalytic nucleophile [active] 137722021037 Recombinase; Region: Recombinase; pfam07508 137722021038 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 137722021039 Helix-turn-helix domain; Region: HTH_17; pfam12728 137722021040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 137722021041 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 137722021042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 137722021043 Transposase; Region: HTH_Tnp_1; pfam01527 137722021044 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 137722021045 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722021046 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722021047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021048 Tetratricopeptide repeat; Region: TPR_16; pfam13432 137722021049 TPR motif; other site 137722021050 binding surface 137722021051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021052 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 137722021053 TPR motif; other site 137722021054 binding surface 137722021055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021056 binding surface 137722021057 TPR motif; other site 137722021058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021059 binding surface 137722021060 TPR motif; other site 137722021061 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 137722021062 Sel1-like repeats; Region: SEL1; smart00671 137722021063 Sel1-like repeats; Region: SEL1; smart00671 137722021064 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 137722021065 Sel1-like repeats; Region: SEL1; smart00671 137722021066 Sel1-like repeats; Region: SEL1; smart00671 137722021067 Sel1-like repeats; Region: SEL1; smart00671 137722021068 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 137722021069 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 137722021070 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722021071 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 137722021072 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 137722021073 putative active site [active] 137722021074 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 137722021075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722021076 Walker A/P-loop; other site 137722021077 ATP binding site [chemical binding]; other site 137722021078 Q-loop/lid; other site 137722021079 ABC transporter signature motif; other site 137722021080 Walker B; other site 137722021081 D-loop; other site 137722021082 H-loop/switch region; other site 137722021083 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 137722021084 Tetratricopeptide repeat; Region: TPR_16; pfam13432 137722021085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021086 TPR motif; other site 137722021087 binding surface 137722021088 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 137722021089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021090 binding surface 137722021091 TPR motif; other site 137722021092 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722021093 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 137722021094 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 137722021095 dimer interface [polypeptide binding]; other site 137722021096 active site 137722021097 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 137722021098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021099 binding surface 137722021100 TPR motif; other site 137722021101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021102 binding surface 137722021103 TPR motif; other site 137722021104 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722021105 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 137722021106 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 137722021107 NADP binding site [chemical binding]; other site 137722021108 active site 137722021109 putative substrate binding site [chemical binding]; other site 137722021110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021111 Tetratricopeptide repeat; Region: TPR_16; pfam13432 137722021112 binding surface 137722021113 TPR motif; other site 137722021114 TPR repeat; Region: TPR_11; pfam13414 137722021115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021116 binding surface 137722021117 TPR motif; other site 137722021118 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 137722021119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 137722021120 TPR motif; other site 137722021121 binding surface 137722021122 TPR repeat; Region: TPR_11; pfam13414 137722021123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021124 binding surface 137722021125 TPR repeat; Region: TPR_11; pfam13414 137722021126 TPR motif; other site 137722021127 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 137722021128 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722021129 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 137722021130 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 137722021131 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722021132 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021133 TPR motif; other site 137722021134 binding surface 137722021135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722021136 Methyltransferase domain; Region: Methyltransf_31; pfam13847 137722021137 S-adenosylmethionine binding site [chemical binding]; other site 137722021138 TPR repeat; Region: TPR_11; pfam13414 137722021139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021140 TPR motif; other site 137722021141 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 137722021142 TPR repeat; Region: TPR_11; pfam13414 137722021143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021144 binding surface 137722021145 TPR motif; other site 137722021146 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722021147 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 137722021148 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 137722021149 P-loop; other site 137722021150 Magnesium ion binding site [ion binding]; other site 137722021151 TPR repeat; Region: TPR_11; pfam13414 137722021152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 137722021153 binding surface 137722021154 TPR motif; other site 137722021155 Tetratricopeptide repeat; Region: TPR_12; pfam13424 137722021156 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722021157 Methyltransferase domain; Region: Methyltransf_23; pfam13489 137722021158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 137722021159 S-adenosylmethionine binding site [chemical binding]; other site 137722021160 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 137722021161 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 137722021162 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 137722021163 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 137722021164 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 137722021165 NAD binding site [chemical binding]; other site 137722021166 substrate binding site [chemical binding]; other site 137722021167 homodimer interface [polypeptide binding]; other site 137722021168 active site 137722021169 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 137722021170 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 137722021171 NADP binding site [chemical binding]; other site 137722021172 active site 137722021173 putative substrate binding site [chemical binding]; other site 137722021174 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 137722021175 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 137722021176 substrate binding site; other site 137722021177 tetramer interface; other site 137722021178 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 137722021179 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 137722021180 NAD binding site [chemical binding]; other site 137722021181 putative substrate binding site 2 [chemical binding]; other site 137722021182 putative substrate binding site 1 [chemical binding]; other site 137722021183 active site 137722021184 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 137722021185 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 137722021186 NAD binding site [chemical binding]; other site 137722021187 homodimer interface [polypeptide binding]; other site 137722021188 active site 137722021189 substrate binding site [chemical binding]; other site 137722021190 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 137722021191 HlyD family secretion protein; Region: HlyD_3; pfam13437 137722021192 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 137722021193 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 137722021194 putative active site [active] 137722021195 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 137722021196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 137722021197 Walker A/P-loop; other site 137722021198 ATP binding site [chemical binding]; other site 137722021199 Q-loop/lid; other site 137722021200 ABC transporter signature motif; other site 137722021201 Walker B; other site 137722021202 D-loop; other site 137722021203 H-loop/switch region; other site 137722021204 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 137722021205 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 137722021206 Substrate binding site; other site 137722021207 Cupin domain; Region: Cupin_2; cl17218