-- dump date   	20140618_210037
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
438753000001	PEP synthetase regulatory protein; Provisional; Region: PRK05339
438753000002	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
438753000003	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
438753000004	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
438753000005	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
438753000006	shikimate binding site; other site
438753000007	NAD(P) binding site [chemical binding]; other site
438753000008	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
438753000009	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
438753000010	CoA-binding site [chemical binding]; other site
438753000011	ATP-binding [chemical binding]; other site
438753000012	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
438753000013	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
438753000014	active site
438753000015	catalytic site [active]
438753000016	substrate binding site [chemical binding]; other site
438753000017	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
438753000018	metal binding site 2 [ion binding]; metal-binding site
438753000019	putative DNA binding helix; other site
438753000020	metal binding site 1 [ion binding]; metal-binding site
438753000021	dimer interface [polypeptide binding]; other site
438753000022	structural Zn2+ binding site [ion binding]; other site
438753000023	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
438753000024	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
438753000025	putative acyl-acceptor binding pocket; other site
438753000026	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
438753000027	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
438753000028	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753000029	FeS/SAM binding site; other site
438753000030	TRAM domain; Region: TRAM; pfam01938
438753000031	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
438753000032	PhoH-like protein; Region: PhoH; pfam02562
438753000033	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
438753000034	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
438753000035	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
438753000036	Transporter associated domain; Region: CorC_HlyC; smart01091
438753000037	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
438753000038	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
438753000039	putative active site [active]
438753000040	catalytic triad [active]
438753000041	putative dimer interface [polypeptide binding]; other site
438753000042	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
438753000043	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753000044	sequence-specific DNA binding site [nucleotide binding]; other site
438753000045	salt bridge; other site
438753000046	S-adenosylmethionine synthetase; Validated; Region: PRK05250
438753000047	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
438753000048	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
438753000049	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
438753000050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753000051	S-adenosylmethionine binding site [chemical binding]; other site
438753000052	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753000053	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753000054	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
438753000055	dimerization interface [polypeptide binding]; other site
438753000056	ribosome maturation protein RimP; Reviewed; Region: PRK00092
438753000057	Sm and related proteins; Region: Sm_like; cl00259
438753000058	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
438753000059	putative oligomer interface [polypeptide binding]; other site
438753000060	putative RNA binding site [nucleotide binding]; other site
438753000061	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
438753000062	NusA N-terminal domain; Region: NusA_N; pfam08529
438753000063	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
438753000064	RNA binding site [nucleotide binding]; other site
438753000065	homodimer interface [polypeptide binding]; other site
438753000066	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
438753000067	G-X-X-G motif; other site
438753000068	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
438753000069	G-X-X-G motif; other site
438753000070	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
438753000071	hypothetical protein; Provisional; Region: PRK09190
438753000072	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
438753000073	putative RNA binding cleft [nucleotide binding]; other site
438753000074	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
438753000075	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
438753000076	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
438753000077	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
438753000078	G1 box; other site
438753000079	putative GEF interaction site [polypeptide binding]; other site
438753000080	GTP/Mg2+ binding site [chemical binding]; other site
438753000081	Switch I region; other site
438753000082	G2 box; other site
438753000083	G3 box; other site
438753000084	Switch II region; other site
438753000085	G4 box; other site
438753000086	G5 box; other site
438753000087	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
438753000088	Translation-initiation factor 2; Region: IF-2; pfam11987
438753000089	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
438753000090	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
438753000091	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
438753000092	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
438753000093	RNA binding site [nucleotide binding]; other site
438753000094	active site
438753000095	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
438753000096	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
438753000097	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753000098	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753000099	dimer interface [polypeptide binding]; other site
438753000100	conserved gate region; other site
438753000101	putative PBP binding loops; other site
438753000102	ABC-ATPase subunit interface; other site
438753000103	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753000104	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753000105	Walker A/P-loop; other site
438753000106	ATP binding site [chemical binding]; other site
438753000107	Q-loop/lid; other site
438753000108	ABC transporter signature motif; other site
438753000109	Walker B; other site
438753000110	D-loop; other site
438753000111	H-loop/switch region; other site
438753000112	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
438753000113	NMT1/THI5 like; Region: NMT1; pfam09084
438753000114	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
438753000115	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
438753000116	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
438753000117	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
438753000118	catalytic residue [active]
438753000119	Transcriptional regulators [Transcription]; Region: MarR; COG1846
438753000120	MarR family; Region: MarR_2; pfam12802
438753000121	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
438753000122	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
438753000123	NAD(P) binding site [chemical binding]; other site
438753000124	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
438753000125	CoenzymeA binding site [chemical binding]; other site
438753000126	subunit interaction site [polypeptide binding]; other site
438753000127	PHB binding site; other site
438753000128	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
438753000129	Proline dehydrogenase; Region: Pro_dh; pfam01619
438753000130	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
438753000131	Glutamate binding site [chemical binding]; other site
438753000132	NAD binding site [chemical binding]; other site
438753000133	catalytic residues [active]
438753000134	AsnC family; Region: AsnC_trans_reg; pfam01037
438753000135	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
438753000136	dimer interaction site [polypeptide binding]; other site
438753000137	substrate-binding tunnel; other site
438753000138	active site
438753000139	catalytic site [active]
438753000140	substrate binding site [chemical binding]; other site
438753000141	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
438753000142	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
438753000143	putative C-terminal domain interface [polypeptide binding]; other site
438753000144	putative GSH binding site (G-site) [chemical binding]; other site
438753000145	putative dimer interface [polypeptide binding]; other site
438753000146	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
438753000147	putative substrate binding pocket (H-site) [chemical binding]; other site
438753000148	putative N-terminal domain interface [polypeptide binding]; other site
438753000149	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
438753000150	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
438753000151	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
438753000152	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
438753000153	active site
438753000154	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
438753000155	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
438753000156	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753000157	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
438753000158	Enoylreductase; Region: PKS_ER; smart00829
438753000159	NAD(P) binding site [chemical binding]; other site
438753000160	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
438753000161	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
438753000162	putative NADP binding site [chemical binding]; other site
438753000163	active site
438753000164	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
438753000165	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
438753000166	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
438753000167	substrate-cofactor binding pocket; other site
438753000168	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753000169	catalytic residue [active]
438753000170	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753000171	NAD(P) binding site [chemical binding]; other site
438753000172	active site
438753000173	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
438753000174	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
438753000175	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
438753000176	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
438753000177	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
438753000178	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
438753000179	Walker A/P-loop; other site
438753000180	ATP binding site [chemical binding]; other site
438753000181	Q-loop/lid; other site
438753000182	ABC transporter signature motif; other site
438753000183	Walker B; other site
438753000184	D-loop; other site
438753000185	H-loop/switch region; other site
438753000186	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
438753000187	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
438753000188	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753000189	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
438753000190	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753000191	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
438753000192	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
438753000193	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753000194	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
438753000195	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753000196	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
438753000197	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
438753000198	Methyltransferase domain; Region: Methyltransf_23; pfam13489
438753000199	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
438753000200	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
438753000201	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753000202	NAD(P) binding site [chemical binding]; other site
438753000203	active site
438753000204	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
438753000205	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
438753000206	NADP-binding site; other site
438753000207	homotetramer interface [polypeptide binding]; other site
438753000208	substrate binding site [chemical binding]; other site
438753000209	homodimer interface [polypeptide binding]; other site
438753000210	active site
438753000211	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753000212	TPR motif; other site
438753000213	TPR repeat; Region: TPR_11; pfam13414
438753000214	binding surface
438753000215	TPR repeat; Region: TPR_11; pfam13414
438753000216	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
438753000217	binding surface
438753000218	TPR motif; other site
438753000219	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
438753000220	Cytochrome P450; Region: p450; cl12078
438753000221	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
438753000222	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
438753000223	Substrate binding site; other site
438753000224	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
438753000225	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
438753000226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753000227	putative substrate translocation pore; other site
438753000228	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753000229	dimerization interface [polypeptide binding]; other site
438753000230	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753000231	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753000232	dimer interface [polypeptide binding]; other site
438753000233	putative CheW interface [polypeptide binding]; other site
438753000234	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753000235	dimer interface [polypeptide binding]; other site
438753000236	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753000237	putative CheW interface [polypeptide binding]; other site
438753000238	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
438753000239	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
438753000240	RNase E interface [polypeptide binding]; other site
438753000241	trimer interface [polypeptide binding]; other site
438753000242	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
438753000243	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
438753000244	RNase E interface [polypeptide binding]; other site
438753000245	trimer interface [polypeptide binding]; other site
438753000246	active site
438753000247	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
438753000248	putative nucleic acid binding region [nucleotide binding]; other site
438753000249	G-X-X-G motif; other site
438753000250	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
438753000251	RNA binding site [nucleotide binding]; other site
438753000252	domain interface; other site
438753000253	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
438753000254	16S/18S rRNA binding site [nucleotide binding]; other site
438753000255	S13e-L30e interaction site [polypeptide binding]; other site
438753000256	25S rRNA binding site [nucleotide binding]; other site
438753000257	probable biosynthetic protein, Pnap_2097 family; Region: biosn_Pnap_2097; TIGR04099
438753000258	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
438753000259	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
438753000260	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
438753000261	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
438753000262	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
438753000263	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
438753000264	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
438753000265	dimerization interface [polypeptide binding]; other site
438753000266	putative ATP binding site [chemical binding]; other site
438753000267	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753000268	Coenzyme A binding pocket [chemical binding]; other site
438753000269	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
438753000270	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753000271	FeS/SAM binding site; other site
438753000272	Predicted amidohydrolase [General function prediction only]; Region: COG0388
438753000273	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
438753000274	putative active site [active]
438753000275	catalytic triad [active]
438753000276	putative dimer interface [polypeptide binding]; other site
438753000277	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
438753000278	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
438753000279	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753000280	DNA-binding site [nucleotide binding]; DNA binding site
438753000281	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753000282	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753000283	homodimer interface [polypeptide binding]; other site
438753000284	catalytic residue [active]
438753000285	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
438753000286	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
438753000287	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
438753000288	malate synthase A; Region: malate_syn_A; TIGR01344
438753000289	active site
438753000290	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
438753000291	thiamine phosphate binding site [chemical binding]; other site
438753000292	active site
438753000293	pyrophosphate binding site [ion binding]; other site
438753000294	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
438753000295	Cysteine-rich domain; Region: CCG; pfam02754
438753000296	Cysteine-rich domain; Region: CCG; pfam02754
438753000297	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
438753000298	putative active site [active]
438753000299	FAD binding domain; Region: FAD_binding_4; pfam01565
438753000300	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
438753000301	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
438753000302	FAD binding domain; Region: FAD_binding_4; pfam01565
438753000303	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753000304	transcriptional activator TtdR; Provisional; Region: PRK09801
438753000305	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
438753000306	putative effector binding pocket; other site
438753000307	dimerization interface [polypeptide binding]; other site
438753000308	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
438753000309	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
438753000310	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
438753000311	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
438753000312	nucleophilic elbow; other site
438753000313	catalytic triad; other site
438753000314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
438753000315	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753000316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753000317	active site
438753000318	phosphorylation site [posttranslational modification]
438753000319	intermolecular recognition site; other site
438753000320	dimerization interface [polypeptide binding]; other site
438753000321	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753000322	DNA binding site [nucleotide binding]
438753000323	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
438753000324	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
438753000325	ligand binding site [chemical binding]; other site
438753000326	flexible hinge region; other site
438753000327	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
438753000328	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
438753000329	putative catalytic site [active]
438753000330	putative phosphate binding site [ion binding]; other site
438753000331	active site
438753000332	metal binding site A [ion binding]; metal-binding site
438753000333	DNA binding site [nucleotide binding]
438753000334	putative AP binding site [nucleotide binding]; other site
438753000335	putative metal binding site B [ion binding]; other site
438753000336	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
438753000337	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
438753000338	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
438753000339	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
438753000340	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
438753000341	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
438753000342	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
438753000343	succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538
438753000344	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753000345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753000346	homodimer interface [polypeptide binding]; other site
438753000347	catalytic residue [active]
438753000348	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
438753000349	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
438753000350	active site
438753000351	Riboflavin kinase; Region: Flavokinase; smart00904
438753000352	Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460
438753000353	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
438753000354	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
438753000355	motif II; other site
438753000356	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
438753000357	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
438753000358	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
438753000359	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
438753000360	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
438753000361	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
438753000362	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
438753000363	RNA binding site [nucleotide binding]; other site
438753000364	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
438753000365	aspartate racemase; Region: asp_race; TIGR00035
438753000366	S-formylglutathione hydrolase; Region: PLN02442
438753000367	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
438753000368	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
438753000369	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
438753000370	substrate binding site [chemical binding]; other site
438753000371	catalytic Zn binding site [ion binding]; other site
438753000372	NAD binding site [chemical binding]; other site
438753000373	structural Zn binding site [ion binding]; other site
438753000374	dimer interface [polypeptide binding]; other site
438753000375	Domain of unknown function DUF87; Region: DUF87; pfam01935
438753000376	HerA helicase [Replication, recombination, and repair]; Region: COG0433
438753000377	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753000378	putative substrate translocation pore; other site
438753000379	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
438753000380	active site
438753000381	catalytic residues [active]
438753000382	metal binding site [ion binding]; metal-binding site
438753000383	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
438753000384	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
438753000385	ATP binding site [chemical binding]; other site
438753000386	putative Mg++ binding site [ion binding]; other site
438753000387	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
438753000388	nucleotide binding region [chemical binding]; other site
438753000389	ATP-binding site [chemical binding]; other site
438753000390	DEAD/H associated; Region: DEAD_assoc; pfam08494
438753000391	acetolactate synthase, catabolic; Region: acolac_catab; TIGR02418
438753000392	Methyltransferase domain; Region: Methyltransf_23; pfam13489
438753000393	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753000394	S-adenosylmethionine binding site [chemical binding]; other site
438753000395	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
438753000396	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
438753000397	active site
438753000398	FMN binding site [chemical binding]; other site
438753000399	substrate binding site [chemical binding]; other site
438753000400	homotetramer interface [polypeptide binding]; other site
438753000401	catalytic residue [active]
438753000402	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
438753000403	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
438753000404	putative active site [active]
438753000405	putative metal binding site [ion binding]; other site
438753000406	Transcriptional regulators [Transcription]; Region: MarR; COG1846
438753000407	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753000408	putative Zn2+ binding site [ion binding]; other site
438753000409	putative DNA binding site [nucleotide binding]; other site
438753000410	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
438753000411	Autotransporter beta-domain; Region: Autotransporter; pfam03797
438753000412	Response regulator receiver domain; Region: Response_reg; pfam00072
438753000413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753000414	active site
438753000415	phosphorylation site [posttranslational modification]
438753000416	intermolecular recognition site; other site
438753000417	dimerization interface [polypeptide binding]; other site
438753000418	malate dehydrogenase; Provisional; Region: PRK13529
438753000419	Malic enzyme, N-terminal domain; Region: malic; pfam00390
438753000420	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
438753000421	NAD(P) binding site [chemical binding]; other site
438753000422	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
438753000423	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
438753000424	TrkA-C domain; Region: TrkA_C; pfam02080
438753000425	TrkA-C domain; Region: TrkA_C; pfam02080
438753000426	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
438753000427	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
438753000428	SLBB domain; Region: SLBB; pfam10531
438753000429	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
438753000430	L-aspartate oxidase; Provisional; Region: PRK06175
438753000431	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
438753000432	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753000433	catalytic loop [active]
438753000434	iron binding site [ion binding]; other site
438753000435	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
438753000436	Predicted permeases [General function prediction only]; Region: COG0679
438753000437	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
438753000438	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753000439	dimer interface [polypeptide binding]; other site
438753000440	phosphorylation site [posttranslational modification]
438753000441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753000442	ATP binding site [chemical binding]; other site
438753000443	Mg2+ binding site [ion binding]; other site
438753000444	G-X-G motif; other site
438753000445	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
438753000446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753000447	active site
438753000448	phosphorylation site [posttranslational modification]
438753000449	intermolecular recognition site; other site
438753000450	dimerization interface [polypeptide binding]; other site
438753000451	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753000452	Walker A motif; other site
438753000453	ATP binding site [chemical binding]; other site
438753000454	Walker B motif; other site
438753000455	arginine finger; other site
438753000456	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
438753000457	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753000458	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753000459	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
438753000460	putative dimerization interface [polypeptide binding]; other site
438753000461	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
438753000462	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
438753000463	dimer interface [polypeptide binding]; other site
438753000464	ADP-ribose binding site [chemical binding]; other site
438753000465	active site
438753000466	nudix motif; other site
438753000467	metal binding site [ion binding]; metal-binding site
438753000468	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
438753000469	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753000470	Walker A/P-loop; other site
438753000471	ATP binding site [chemical binding]; other site
438753000472	Q-loop/lid; other site
438753000473	ABC transporter signature motif; other site
438753000474	Walker B; other site
438753000475	D-loop; other site
438753000476	H-loop/switch region; other site
438753000477	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753000478	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753000479	Walker A/P-loop; other site
438753000480	ATP binding site [chemical binding]; other site
438753000481	Q-loop/lid; other site
438753000482	ABC transporter signature motif; other site
438753000483	Walker B; other site
438753000484	D-loop; other site
438753000485	H-loop/switch region; other site
438753000486	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753000487	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
438753000488	putative active site [active]
438753000489	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
438753000490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753000491	ABC-ATPase subunit interface; other site
438753000492	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
438753000493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753000494	dimer interface [polypeptide binding]; other site
438753000495	conserved gate region; other site
438753000496	putative PBP binding loops; other site
438753000497	ABC-ATPase subunit interface; other site
438753000498	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
438753000499	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
438753000500	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
438753000501	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
438753000502	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
438753000503	Cytochrome c2 [Energy production and conversion]; Region: COG3474
438753000504	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
438753000505	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
438753000506	Ligand binding site; other site
438753000507	oligomer interface; other site
438753000508	prephenate dehydratase; Provisional; Region: PRK11899
438753000509	Prephenate dehydratase; Region: PDT; pfam00800
438753000510	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
438753000511	putative L-Phe binding site [chemical binding]; other site
438753000512	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
438753000513	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
438753000514	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
438753000515	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
438753000516	putative NADH binding site [chemical binding]; other site
438753000517	putative active site [active]
438753000518	nudix motif; other site
438753000519	putative metal binding site [ion binding]; other site
438753000520	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
438753000521	nucleotide binding site/active site [active]
438753000522	HIT family signature motif; other site
438753000523	catalytic residue [active]
438753000524	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
438753000525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753000526	Walker A motif; other site
438753000527	ATP binding site [chemical binding]; other site
438753000528	Walker B motif; other site
438753000529	arginine finger; other site
438753000530	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
438753000531	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
438753000532	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753000533	TPR motif; other site
438753000534	binding surface
438753000535	hypothetical protein; Validated; Region: PRK00153
438753000536	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
438753000537	apolar tunnel; other site
438753000538	heme binding site [chemical binding]; other site
438753000539	dimerization interface [polypeptide binding]; other site
438753000540	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
438753000541	HPP family; Region: HPP; pfam04982
438753000542	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
438753000543	recombination protein RecR; Reviewed; Region: recR; PRK00076
438753000544	RecR protein; Region: RecR; pfam02132
438753000545	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
438753000546	putative active site [active]
438753000547	putative metal-binding site [ion binding]; other site
438753000548	tetramer interface [polypeptide binding]; other site
438753000549	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
438753000550	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
438753000551	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
438753000552	nucleotide binding pocket [chemical binding]; other site
438753000553	K-X-D-G motif; other site
438753000554	catalytic site [active]
438753000555	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
438753000556	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
438753000557	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
438753000558	Dimer interface [polypeptide binding]; other site
438753000559	BRCT sequence motif; other site
438753000560	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
438753000561	Cytochrome c; Region: Cytochrom_C; pfam00034
438753000562	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
438753000563	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
438753000564	OpgC protein; Region: OpgC_C; pfam10129
438753000565	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
438753000566	active site
438753000567	oxyanion hole [active]
438753000568	catalytic triad [active]
438753000569	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
438753000570	catalytic core [active]
438753000571	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
438753000572	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
438753000573	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
438753000574	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
438753000575	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
438753000576	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
438753000577	active site
438753000578	dimer interface [polypeptide binding]; other site
438753000579	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
438753000580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753000581	S-adenosylmethionine binding site [chemical binding]; other site
438753000582	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
438753000583	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
438753000584	active site
438753000585	tetramer interface; other site
438753000586	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
438753000587	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
438753000588	NAD binding site [chemical binding]; other site
438753000589	homodimer interface [polypeptide binding]; other site
438753000590	active site
438753000591	substrate binding site [chemical binding]; other site
438753000592	Transglycosylase SLT domain; Region: SLT_2; pfam13406
438753000593	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
438753000594	N-acetyl-D-glucosamine binding site [chemical binding]; other site
438753000595	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
438753000596	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
438753000597	dimerization interface [polypeptide binding]; other site
438753000598	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
438753000599	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753000600	ATP binding site [chemical binding]; other site
438753000601	Mg2+ binding site [ion binding]; other site
438753000602	G-X-G motif; other site
438753000603	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753000604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753000605	active site
438753000606	phosphorylation site [posttranslational modification]
438753000607	intermolecular recognition site; other site
438753000608	dimerization interface [polypeptide binding]; other site
438753000609	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753000610	DNA binding site [nucleotide binding]
438753000611	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
438753000612	5-oxoprolinase; Region: PLN02666
438753000613	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
438753000614	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
438753000615	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
438753000616	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
438753000617	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
438753000618	DctM-like transporters; Region: DctM; pfam06808
438753000619	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
438753000620	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
438753000621	MarR family; Region: MarR_2; cl17246
438753000622	Protein of unknown function, DUF1537; Region: DUF1537; pfam07005
438753000623	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
438753000624	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
438753000625	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
438753000626	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
438753000627	putative active site [active]
438753000628	metal binding site [ion binding]; metal-binding site
438753000629	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
438753000630	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
438753000631	inhibitor site; inhibition site
438753000632	active site
438753000633	dimer interface [polypeptide binding]; other site
438753000634	catalytic residue [active]
438753000635	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753000636	D-galactonate transporter; Region: 2A0114; TIGR00893
438753000637	putative substrate translocation pore; other site
438753000638	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
438753000639	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
438753000640	ligand binding site [chemical binding]; other site
438753000641	NAD binding site [chemical binding]; other site
438753000642	dimerization interface [polypeptide binding]; other site
438753000643	catalytic site [active]
438753000644	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
438753000645	Predicted transcriptional regulators [Transcription]; Region: COG1733
438753000646	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
438753000647	NmrA-like family; Region: NmrA; pfam05368
438753000648	NAD(P) binding site [chemical binding]; other site
438753000649	active site lysine
438753000650	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
438753000651	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
438753000652	N-terminal plug; other site
438753000653	ligand-binding site [chemical binding]; other site
438753000654	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
438753000655	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
438753000656	Walker A/P-loop; other site
438753000657	ATP binding site [chemical binding]; other site
438753000658	Q-loop/lid; other site
438753000659	ABC transporter signature motif; other site
438753000660	Walker B; other site
438753000661	D-loop; other site
438753000662	H-loop/switch region; other site
438753000663	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
438753000664	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
438753000665	ABC-ATPase subunit  interface; other site
438753000666	dimer interface [polypeptide binding]; other site
438753000667	putative PBP binding regions; other site
438753000668	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
438753000669	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
438753000670	ABC-ATPase subunit  interface; other site
438753000671	dimer interface [polypeptide binding]; other site
438753000672	putative PBP binding regions; other site
438753000673	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
438753000674	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
438753000675	intersubunit interface [polypeptide binding]; other site
438753000676	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
438753000677	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
438753000678	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795
438753000679	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
438753000680	tellurite resistance protein terB; Region: terB; cd07176
438753000681	putative metal binding site [ion binding]; other site
438753000682	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
438753000683	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
438753000684	Acetokinase family; Region: Acetate_kinase; cl17229
438753000685	propionate/acetate kinase; Provisional; Region: PRK12379
438753000686	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
438753000687	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
438753000688	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
438753000689	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
438753000690	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
438753000691	magnesium-transporting ATPase; Provisional; Region: PRK15122
438753000692	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
438753000693	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
438753000694	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
438753000695	Soluble P-type ATPase [General function prediction only]; Region: COG4087
438753000696	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
438753000697	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753000698	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753000699	ATP binding site [chemical binding]; other site
438753000700	Mg2+ binding site [ion binding]; other site
438753000701	G-X-G motif; other site
438753000702	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
438753000703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753000704	active site
438753000705	phosphorylation site [posttranslational modification]
438753000706	intermolecular recognition site; other site
438753000707	dimerization interface [polypeptide binding]; other site
438753000708	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
438753000709	DNA binding residues [nucleotide binding]
438753000710	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
438753000711	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
438753000712	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
438753000713	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
438753000714	dimerization interface [polypeptide binding]; other site
438753000715	ligand binding site [chemical binding]; other site
438753000716	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753000717	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753000718	TM-ABC transporter signature motif; other site
438753000719	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753000720	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753000721	TM-ABC transporter signature motif; other site
438753000722	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753000723	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753000724	Walker A/P-loop; other site
438753000725	ATP binding site [chemical binding]; other site
438753000726	Q-loop/lid; other site
438753000727	ABC transporter signature motif; other site
438753000728	Walker B; other site
438753000729	D-loop; other site
438753000730	H-loop/switch region; other site
438753000731	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753000732	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753000733	Walker A/P-loop; other site
438753000734	ATP binding site [chemical binding]; other site
438753000735	Q-loop/lid; other site
438753000736	ABC transporter signature motif; other site
438753000737	Walker B; other site
438753000738	D-loop; other site
438753000739	H-loop/switch region; other site
438753000740	acetylornithine deacetylase; Provisional; Region: PRK07522
438753000741	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
438753000742	metal binding site [ion binding]; metal-binding site
438753000743	putative dimer interface [polypeptide binding]; other site
438753000744	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
438753000745	homotrimer interaction site [polypeptide binding]; other site
438753000746	putative active site [active]
438753000747	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
438753000748	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753000749	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753000750	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
438753000751	putative substrate binding pocket [chemical binding]; other site
438753000752	dimerization interface [polypeptide binding]; other site
438753000753	Predicted transcriptional regulators [Transcription]; Region: COG1733
438753000754	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
438753000755	short chain dehydrogenase; Provisional; Region: PRK06500
438753000756	classical (c) SDRs; Region: SDR_c; cd05233
438753000757	NAD(P) binding site [chemical binding]; other site
438753000758	active site
438753000759	Predicted transcriptional regulators [Transcription]; Region: COG1733
438753000760	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753000761	putative Zn2+ binding site [ion binding]; other site
438753000762	putative DNA binding site [nucleotide binding]; other site
438753000763	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
438753000764	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
438753000765	putative NAD(P) binding site [chemical binding]; other site
438753000766	dimer interface [polypeptide binding]; other site
438753000767	Isochorismatase family; Region: Isochorismatase; pfam00857
438753000768	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
438753000769	catalytic triad [active]
438753000770	conserved cis-peptide bond; other site
438753000771	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
438753000772	active site
438753000773	FRG domain; Region: FRG; pfam08867
438753000774	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
438753000775	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
438753000776	G1 box; other site
438753000777	putative GEF interaction site [polypeptide binding]; other site
438753000778	GTP/Mg2+ binding site [chemical binding]; other site
438753000779	Switch I region; other site
438753000780	G2 box; other site
438753000781	G3 box; other site
438753000782	Switch II region; other site
438753000783	G4 box; other site
438753000784	G5 box; other site
438753000785	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
438753000786	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
438753000787	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
438753000788	trimer interface [polypeptide binding]; other site
438753000789	active site
438753000790	substrate binding site [chemical binding]; other site
438753000791	CoA binding site [chemical binding]; other site
438753000792	HTH-like domain; Region: HTH_21; pfam13276
438753000793	Integrase core domain; Region: rve; pfam00665
438753000794	Integrase core domain; Region: rve_3; pfam13683
438753000795	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
438753000796	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
438753000797	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
438753000798	active site
438753000799	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
438753000800	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
438753000801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753000802	Walker A motif; other site
438753000803	ATP binding site [chemical binding]; other site
438753000804	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
438753000805	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
438753000806	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
438753000807	active site
438753000808	HslU subunit interaction site [polypeptide binding]; other site
438753000809	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
438753000810	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
438753000811	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
438753000812	Methyltransferase domain; Region: Methyltransf_23; pfam13489
438753000813	Methyltransferase domain; Region: Methyltransf_11; pfam08241
438753000814	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753000815	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753000816	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
438753000817	homotrimer interaction site [polypeptide binding]; other site
438753000818	putative active site [active]
438753000819	Methyltransferase domain; Region: Methyltransf_31; pfam13847
438753000820	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753000821	S-adenosylmethionine binding site [chemical binding]; other site
438753000822	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
438753000823	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
438753000824	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
438753000825	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
438753000826	ATP binding site [chemical binding]; other site
438753000827	putative Mg++ binding site [ion binding]; other site
438753000828	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
438753000829	nucleotide binding region [chemical binding]; other site
438753000830	ATP-binding site [chemical binding]; other site
438753000831	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
438753000832	RNA binding surface [nucleotide binding]; other site
438753000833	Ferredoxin [Energy production and conversion]; Region: COG1146
438753000834	4Fe-4S binding domain; Region: Fer4; cl02805
438753000835	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
438753000836	siroheme synthase; Provisional; Region: cysG; PRK10637
438753000837	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
438753000838	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
438753000839	active site
438753000840	SAM binding site [chemical binding]; other site
438753000841	homodimer interface [polypeptide binding]; other site
438753000842	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
438753000843	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
438753000844	ATP binding site [chemical binding]; other site
438753000845	substrate interface [chemical binding]; other site
438753000846	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
438753000847	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
438753000848	dimerization interface [polypeptide binding]; other site
438753000849	ligand binding site [chemical binding]; other site
438753000850	NADP binding site [chemical binding]; other site
438753000851	catalytic site [active]
438753000852	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
438753000853	Bacterial SH3 domain; Region: SH3_4; pfam06347
438753000854	Bacterial SH3 domain; Region: SH3_4; pfam06347
438753000855	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
438753000856	ABC-2 type transporter; Region: ABC2_membrane; cl17235
438753000857	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
438753000858	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
438753000859	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
438753000860	Walker A/P-loop; other site
438753000861	ATP binding site [chemical binding]; other site
438753000862	Q-loop/lid; other site
438753000863	ABC transporter signature motif; other site
438753000864	Walker B; other site
438753000865	D-loop; other site
438753000866	H-loop/switch region; other site
438753000867	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
438753000868	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753000869	putative DNA binding site [nucleotide binding]; other site
438753000870	putative Zn2+ binding site [ion binding]; other site
438753000871	AsnC family; Region: AsnC_trans_reg; pfam01037
438753000872	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753000873	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753000874	substrate binding pocket [chemical binding]; other site
438753000875	membrane-bound complex binding site; other site
438753000876	Predicted esterase [General function prediction only]; Region: COG0400
438753000877	putative hydrolase; Provisional; Region: PRK11460
438753000878	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
438753000879	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753000880	Zn binding site [ion binding]; other site
438753000881	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
438753000882	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753000883	Zn binding site [ion binding]; other site
438753000884	Predicted membrane protein [Function unknown]; Region: COG2259
438753000885	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753000886	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753000887	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753000888	dimerization interface [polypeptide binding]; other site
438753000889	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
438753000890	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
438753000891	C-terminal domain interface [polypeptide binding]; other site
438753000892	GSH binding site (G-site) [chemical binding]; other site
438753000893	dimer interface [polypeptide binding]; other site
438753000894	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
438753000895	N-terminal domain interface [polypeptide binding]; other site
438753000896	putative dimer interface [polypeptide binding]; other site
438753000897	active site
438753000898	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
438753000899	putative deacylase active site [active]
438753000900	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
438753000901	Protein of unknown function DUF72; Region: DUF72; pfam01904
438753000902	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
438753000903	Fe-S cluster binding site [ion binding]; other site
438753000904	active site
438753000905	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
438753000906	FAD binding domain; Region: FAD_binding_4; pfam01565
438753000907	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753000908	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753000909	dimer interface [polypeptide binding]; other site
438753000910	putative CheW interface [polypeptide binding]; other site
438753000911	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
438753000912	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
438753000913	transmembrane helices; other site
438753000914	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
438753000915	GTP-binding protein LepA; Provisional; Region: PRK05433
438753000916	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
438753000917	G1 box; other site
438753000918	putative GEF interaction site [polypeptide binding]; other site
438753000919	GTP/Mg2+ binding site [chemical binding]; other site
438753000920	Switch I region; other site
438753000921	G2 box; other site
438753000922	G3 box; other site
438753000923	Switch II region; other site
438753000924	G4 box; other site
438753000925	G5 box; other site
438753000926	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
438753000927	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
438753000928	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
438753000929	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
438753000930	HemY protein N-terminus; Region: HemY_N; pfam07219
438753000931	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
438753000932	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
438753000933	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
438753000934	active site
438753000935	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
438753000936	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
438753000937	domain interfaces; other site
438753000938	active site
438753000939	UGMP family protein; Validated; Region: PRK09604
438753000940	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
438753000941	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
438753000942	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
438753000943	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
438753000944	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
438753000945	EVE domain; Region: EVE; pfam01878
438753000946	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
438753000947	putative DNA binding site [nucleotide binding]; other site
438753000948	putative Zn2+ binding site [ion binding]; other site
438753000949	AsnC family; Region: AsnC_trans_reg; pfam01037
438753000950	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
438753000951	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
438753000952	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753000953	catalytic residue [active]
438753000954	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
438753000955	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753000956	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753000957	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
438753000958	substrate binding pocket [chemical binding]; other site
438753000959	dimerization interface [polypeptide binding]; other site
438753000960	lytic murein transglycosylase; Region: MltB_2; TIGR02283
438753000961	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
438753000962	N-acetyl-D-glucosamine binding site [chemical binding]; other site
438753000963	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
438753000964	Membrane transport protein; Region: Mem_trans; cl09117
438753000965	Protein of unknown function (DUF796); Region: DUF796; pfam05638
438753000966	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
438753000967	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
438753000968	catalytic residue [active]
438753000969	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753000970	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753000971	metal binding site [ion binding]; metal-binding site
438753000972	active site
438753000973	I-site; other site
438753000974	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
438753000975	NlpC/P60 family; Region: NLPC_P60; cl17555
438753000976	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
438753000977	interface (dimer of trimers) [polypeptide binding]; other site
438753000978	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
438753000979	Substrate-binding/catalytic site; other site
438753000980	Zn-binding sites [ion binding]; other site
438753000981	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
438753000982	transcriptional regulator; Provisional; Region: PRK10632
438753000983	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753000984	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753000985	dimerization interface [polypeptide binding]; other site
438753000986	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
438753000987	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753000988	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
438753000989	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
438753000990	active site
438753000991	substrate binding site [chemical binding]; other site
438753000992	metal binding site [ion binding]; metal-binding site
438753000993	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
438753000994	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
438753000995	putative Mg++ binding site [ion binding]; other site
438753000996	nucleotide binding region [chemical binding]; other site
438753000997	helicase superfamily c-terminal domain; Region: HELICc; smart00490
438753000998	Helicase associated domain (HA2); Region: HA2; pfam04408
438753000999	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
438753001000	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
438753001001	structural tetrad; other site
438753001002	FOG: WD40 repeat [General function prediction only]; Region: COG2319
438753001003	acetoacetate decarboxylase; Provisional; Region: PRK02265
438753001004	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
438753001005	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
438753001006	active site
438753001007	nucleophile elbow; other site
438753001008	Patatin phospholipase; Region: DUF3734; pfam12536
438753001009	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753001010	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753001011	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753001012	dimerization interface [polypeptide binding]; other site
438753001013	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
438753001014	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753001015	DNA-binding site [nucleotide binding]; DNA binding site
438753001016	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753001017	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753001018	homodimer interface [polypeptide binding]; other site
438753001019	catalytic residue [active]
438753001020	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
438753001021	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
438753001022	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
438753001023	putative C-terminal domain interface [polypeptide binding]; other site
438753001024	putative GSH binding site (G-site) [chemical binding]; other site
438753001025	putative dimer interface [polypeptide binding]; other site
438753001026	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
438753001027	putative N-terminal domain interface [polypeptide binding]; other site
438753001028	putative dimer interface [polypeptide binding]; other site
438753001029	putative substrate binding pocket (H-site) [chemical binding]; other site
438753001030	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
438753001031	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
438753001032	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
438753001033	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
438753001034	Predicted methyltransferase [General function prediction only]; Region: COG3897
438753001035	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
438753001036	NAD(P) binding site [chemical binding]; other site
438753001037	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
438753001038	Protein of unknown function (DUF423); Region: DUF423; cl01008
438753001039	acetyl-CoA synthetase; Provisional; Region: PRK00174
438753001040	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
438753001041	active site
438753001042	CoA binding site [chemical binding]; other site
438753001043	acyl-activating enzyme (AAE) consensus motif; other site
438753001044	AMP binding site [chemical binding]; other site
438753001045	acetate binding site [chemical binding]; other site
438753001046	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
438753001047	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
438753001048	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
438753001049	dimer interface [polypeptide binding]; other site
438753001050	[2Fe-2S] cluster binding site [ion binding]; other site
438753001051	tartrate dehydrogenase; Region: TTC; TIGR02089
438753001052	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
438753001053	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
438753001054	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
438753001055	NAD(P) binding site [chemical binding]; other site
438753001056	homotetramer interface [polypeptide binding]; other site
438753001057	homodimer interface [polypeptide binding]; other site
438753001058	active site
438753001059	putative acyltransferase; Provisional; Region: PRK05790
438753001060	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
438753001061	dimer interface [polypeptide binding]; other site
438753001062	active site
438753001063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
438753001064	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
438753001065	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
438753001066	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753001067	metal binding site [ion binding]; metal-binding site
438753001068	active site
438753001069	I-site; other site
438753001070	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753001071	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
438753001072	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
438753001073	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
438753001074	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753001075	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753001076	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
438753001077	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
438753001078	heterotetramer interface [polypeptide binding]; other site
438753001079	active site pocket [active]
438753001080	cleavage site
438753001081	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
438753001082	active site
438753001083	8-oxo-dGMP binding site [chemical binding]; other site
438753001084	nudix motif; other site
438753001085	metal binding site [ion binding]; metal-binding site
438753001086	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
438753001087	active site
438753001088	Methyltransferase domain; Region: Methyltransf_23; pfam13489
438753001089	Methyltransferase domain; Region: Methyltransf_11; pfam08241
438753001090	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
438753001091	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
438753001092	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
438753001093	NAD binding site [chemical binding]; other site
438753001094	substrate binding site [chemical binding]; other site
438753001095	catalytic Zn binding site [ion binding]; other site
438753001096	tetramer interface [polypeptide binding]; other site
438753001097	structural Zn binding site [ion binding]; other site
438753001098	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
438753001099	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
438753001100	NAD(P) binding site [chemical binding]; other site
438753001101	catalytic residues [active]
438753001102	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
438753001103	DctM-like transporters; Region: DctM; pfam06808
438753001104	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
438753001105	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
438753001106	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
438753001107	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
438753001108	MOFRL family; Region: MOFRL; pfam05161
438753001109	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
438753001110	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
438753001111	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
438753001112	TPP-binding site [chemical binding]; other site
438753001113	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
438753001114	PYR/PP interface [polypeptide binding]; other site
438753001115	dimer interface [polypeptide binding]; other site
438753001116	TPP binding site [chemical binding]; other site
438753001117	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
438753001118	Protein of unknown function DUF72; Region: DUF72; pfam01904
438753001119	Ion channel; Region: Ion_trans_2; pfam07885
438753001120	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
438753001121	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
438753001122	G1 box; other site
438753001123	putative GEF interaction site [polypeptide binding]; other site
438753001124	GTP/Mg2+ binding site [chemical binding]; other site
438753001125	Switch I region; other site
438753001126	G2 box; other site
438753001127	G3 box; other site
438753001128	Switch II region; other site
438753001129	G4 box; other site
438753001130	G5 box; other site
438753001131	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
438753001132	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
438753001133	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753001134	Coenzyme A binding pocket [chemical binding]; other site
438753001135	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
438753001136	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
438753001137	active site
438753001138	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
438753001139	dimer interface [polypeptide binding]; other site
438753001140	catalytic residues [active]
438753001141	substrate binding site [chemical binding]; other site
438753001142	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
438753001143	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
438753001144	substrate-cofactor binding pocket; other site
438753001145	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753001146	catalytic residue [active]
438753001147	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
438753001148	Transglycosylase; Region: Transgly; pfam00912
438753001149	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
438753001150	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
438753001151	PII uridylyl-transferase; Provisional; Region: PRK05092
438753001152	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
438753001153	metal binding triad; other site
438753001154	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
438753001155	HD domain; Region: HD; pfam01966
438753001156	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
438753001157	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
438753001158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
438753001159	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
438753001160	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
438753001161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753001162	putative substrate translocation pore; other site
438753001163	TM2 domain; Region: TM2; pfam05154
438753001164	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
438753001165	30S subunit binding site; other site
438753001166	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
438753001167	active site
438753001168	phosphorylation site [posttranslational modification]
438753001169	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
438753001170	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
438753001171	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
438753001172	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
438753001173	putative dimer interface [polypeptide binding]; other site
438753001174	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
438753001175	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
438753001176	active site
438753001177	FMN binding site [chemical binding]; other site
438753001178	substrate binding site [chemical binding]; other site
438753001179	3Fe-4S cluster binding site [ion binding]; other site
438753001180	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
438753001181	AP (apurinic/apyrimidinic) site pocket; other site
438753001182	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
438753001183	DNA interaction; other site
438753001184	Metal-binding active site; metal-binding site
438753001185	Response regulator receiver domain; Region: Response_reg; pfam00072
438753001186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753001187	active site
438753001188	phosphorylation site [posttranslational modification]
438753001189	intermolecular recognition site; other site
438753001190	dimerization interface [polypeptide binding]; other site
438753001191	CHASE3 domain; Region: CHASE3; pfam05227
438753001192	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
438753001193	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753001194	putative active site [active]
438753001195	heme pocket [chemical binding]; other site
438753001196	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753001197	dimer interface [polypeptide binding]; other site
438753001198	phosphorylation site [posttranslational modification]
438753001199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753001200	ATP binding site [chemical binding]; other site
438753001201	Mg2+ binding site [ion binding]; other site
438753001202	G-X-G motif; other site
438753001203	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
438753001204	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
438753001205	catalytic triad [active]
438753001206	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
438753001207	putative metal binding site [ion binding]; other site
438753001208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753001209	Response regulator receiver domain; Region: Response_reg; pfam00072
438753001210	active site
438753001211	phosphorylation site [posttranslational modification]
438753001212	intermolecular recognition site; other site
438753001213	dimerization interface [polypeptide binding]; other site
438753001214	two-component response regulator; Provisional; Region: PRK09191
438753001215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753001216	active site
438753001217	phosphorylation site [posttranslational modification]
438753001218	intermolecular recognition site; other site
438753001219	dimerization interface [polypeptide binding]; other site
438753001220	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
438753001221	biotin synthase; Region: bioB; TIGR00433
438753001222	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753001223	FeS/SAM binding site; other site
438753001224	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
438753001225	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
438753001226	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753001227	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753001228	DNA-binding site [nucleotide binding]; DNA binding site
438753001229	FCD domain; Region: FCD; pfam07729
438753001230	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753001231	non-specific DNA binding site [nucleotide binding]; other site
438753001232	salt bridge; other site
438753001233	sequence-specific DNA binding site [nucleotide binding]; other site
438753001234	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
438753001235	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
438753001236	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
438753001237	dimerization interface [polypeptide binding]; other site
438753001238	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753001239	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753001240	dimer interface [polypeptide binding]; other site
438753001241	putative CheW interface [polypeptide binding]; other site
438753001242	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
438753001243	metal binding site 2 [ion binding]; metal-binding site
438753001244	putative DNA binding helix; other site
438753001245	metal binding site 1 [ion binding]; metal-binding site
438753001246	dimer interface [polypeptide binding]; other site
438753001247	structural Zn2+ binding site [ion binding]; other site
438753001248	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
438753001249	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
438753001250	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
438753001251	active site
438753001252	Predicted esterase [General function prediction only]; Region: COG0400
438753001253	putative hydrolase; Provisional; Region: PRK11460
438753001254	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
438753001255	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
438753001256	minor groove reading motif; other site
438753001257	helix-hairpin-helix signature motif; other site
438753001258	substrate binding pocket [chemical binding]; other site
438753001259	active site
438753001260	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
438753001261	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
438753001262	active site
438753001263	HIGH motif; other site
438753001264	nucleotide binding site [chemical binding]; other site
438753001265	active site
438753001266	KMSKS motif; other site
438753001267	Predicted permeases [General function prediction only]; Region: COG0679
438753001268	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
438753001269	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
438753001270	Cu(I) binding site [ion binding]; other site
438753001271	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
438753001272	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
438753001273	DXD motif; other site
438753001274	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753001275	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753001276	substrate binding pocket [chemical binding]; other site
438753001277	membrane-bound complex binding site; other site
438753001278	hinge residues; other site
438753001279	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
438753001280	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
438753001281	active site
438753001282	nucleotide binding site [chemical binding]; other site
438753001283	HIGH motif; other site
438753001284	KMSKS motif; other site
438753001285	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-1; cd12808
438753001286	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
438753001287	catalytic site [active]
438753001288	Acyltransferase family; Region: Acyl_transf_3; pfam01757
438753001289	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
438753001290	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
438753001291	dimer interface [polypeptide binding]; other site
438753001292	decamer (pentamer of dimers) interface [polypeptide binding]; other site
438753001293	catalytic triad [active]
438753001294	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
438753001295	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
438753001296	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
438753001297	Predicted transcriptional regulator [Transcription]; Region: COG2932
438753001298	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
438753001299	Catalytic site [active]
438753001300	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
438753001301	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753001302	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
438753001303	Uncharacterized conserved protein [Function unknown]; Region: COG2128
438753001304	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
438753001305	Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364
438753001306	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
438753001307	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
438753001308	active site
438753001309	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
438753001310	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
438753001311	putative trimer interface [polypeptide binding]; other site
438753001312	putative CoA binding site [chemical binding]; other site
438753001313	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
438753001314	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
438753001315	active site
438753001316	DNA binding site [nucleotide binding]
438753001317	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
438753001318	DNA binding site [nucleotide binding]
438753001319	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
438753001320	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
438753001321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753001322	S-adenosylmethionine binding site [chemical binding]; other site
438753001323	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
438753001324	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
438753001325	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
438753001326	nudix motif; other site
438753001327	Protein of unknown function (DUF2385); Region: DUF2385; pfam09539
438753001328	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
438753001329	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
438753001330	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
438753001331	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
438753001332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753001333	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753001334	putative substrate translocation pore; other site
438753001335	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
438753001336	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
438753001337	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
438753001338	DNA-binding site [nucleotide binding]; DNA binding site
438753001339	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753001340	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753001341	homodimer interface [polypeptide binding]; other site
438753001342	catalytic residue [active]
438753001343	putative acetyltransferase; Provisional; Region: PRK03624
438753001344	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753001345	Coenzyme A binding pocket [chemical binding]; other site
438753001346	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
438753001347	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
438753001348	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
438753001349	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
438753001350	pyruvate phosphate dikinase; Provisional; Region: PRK09279
438753001351	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
438753001352	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
438753001353	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
438753001354	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
438753001355	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
438753001356	ligand binding site [chemical binding]; other site
438753001357	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
438753001358	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
438753001359	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
438753001360	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
438753001361	putative active site [active]
438753001362	Zn binding site [ion binding]; other site
438753001363	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
438753001364	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
438753001365	GAF domain; Region: GAF; pfam01590
438753001366	PAS domain S-box; Region: sensory_box; TIGR00229
438753001367	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753001368	putative active site [active]
438753001369	heme pocket [chemical binding]; other site
438753001370	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753001371	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753001372	metal binding site [ion binding]; metal-binding site
438753001373	active site
438753001374	I-site; other site
438753001375	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753001376	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
438753001377	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
438753001378	inhibitor binding site; inhibition site
438753001379	catalytic motif [active]
438753001380	Catalytic residue [active]
438753001381	Active site flap [active]
438753001382	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
438753001383	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753001384	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
438753001385	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753001386	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753001387	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
438753001388	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753001389	catalytic loop [active]
438753001390	iron binding site [ion binding]; other site
438753001391	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
438753001392	Predicted transcriptional regulators [Transcription]; Region: COG1733
438753001393	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753001394	dimerization interface [polypeptide binding]; other site
438753001395	putative DNA binding site [nucleotide binding]; other site
438753001396	putative Zn2+ binding site [ion binding]; other site
438753001397	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
438753001398	NADH(P)-binding; Region: NAD_binding_10; pfam13460
438753001399	NAD binding site [chemical binding]; other site
438753001400	putative active site [active]
438753001401	substrate binding site [chemical binding]; other site
438753001402	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
438753001403	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
438753001404	catalytic residues [active]
438753001405	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
438753001406	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
438753001407	ring oligomerisation interface [polypeptide binding]; other site
438753001408	ATP/Mg binding site [chemical binding]; other site
438753001409	stacking interactions; other site
438753001410	hinge regions; other site
438753001411	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
438753001412	oligomerisation interface [polypeptide binding]; other site
438753001413	mobile loop; other site
438753001414	roof hairpin; other site
438753001415	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753001416	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
438753001417	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
438753001418	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753001419	FeS/SAM binding site; other site
438753001420	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
438753001421	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
438753001422	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
438753001423	ligand binding site [chemical binding]; other site
438753001424	homodimer interface [polypeptide binding]; other site
438753001425	NAD(P) binding site [chemical binding]; other site
438753001426	trimer interface B [polypeptide binding]; other site
438753001427	trimer interface A [polypeptide binding]; other site
438753001428	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
438753001429	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
438753001430	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
438753001431	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
438753001432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753001433	putative substrate translocation pore; other site
438753001434	MarR family; Region: MarR_2; pfam12802
438753001435	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
438753001436	active site
438753001437	oxyanion hole [active]
438753001438	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
438753001439	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
438753001440	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
438753001441	active site
438753001442	Zn binding site [ion binding]; other site
438753001443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753001444	Response regulator receiver domain; Region: Response_reg; pfam00072
438753001445	active site
438753001446	phosphorylation site [posttranslational modification]
438753001447	intermolecular recognition site; other site
438753001448	dimerization interface [polypeptide binding]; other site
438753001449	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
438753001450	DNA-binding interface [nucleotide binding]; DNA binding site
438753001451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
438753001452	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
438753001453	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
438753001454	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
438753001455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
438753001456	Peptidase M15; Region: Peptidase_M15_3; cl01194
438753001457	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
438753001458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
438753001459	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
438753001460	EamA-like transporter family; Region: EamA; pfam00892
438753001461	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
438753001462	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753001463	TPR motif; other site
438753001464	binding surface
438753001465	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
438753001466	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
438753001467	Stanniocalcin family; Region: Stanniocalcin; pfam03298
438753001468	ABC1 family; Region: ABC1; pfam03109
438753001469	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
438753001470	Protein of unknown function (DUF461); Region: DUF461; pfam04314
438753001471	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753001472	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753001473	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753001474	dimerization interface [polypeptide binding]; other site
438753001475	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
438753001476	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
438753001477	DNA methylase; Region: N6_N4_Mtase; pfam01555
438753001478	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
438753001479	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
438753001480	minor groove reading motif; other site
438753001481	helix-hairpin-helix signature motif; other site
438753001482	substrate binding pocket [chemical binding]; other site
438753001483	active site
438753001484	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
438753001485	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
438753001486	DNA binding and oxoG recognition site [nucleotide binding]
438753001487	Protein of unknown function (DUF721); Region: DUF721; cl02324
438753001488	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
438753001489	Thioredoxin; Region: Thioredoxin_4; pfam13462
438753001490	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
438753001491	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
438753001492	active site
438753001493	dimer interface [polypeptide binding]; other site
438753001494	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
438753001495	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
438753001496	active site
438753001497	FMN binding site [chemical binding]; other site
438753001498	substrate binding site [chemical binding]; other site
438753001499	3Fe-4S cluster binding site [ion binding]; other site
438753001500	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
438753001501	domain interface; other site
438753001502	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
438753001503	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
438753001504	Predicted membrane protein [Function unknown]; Region: COG1238
438753001505	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
438753001506	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
438753001507	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
438753001508	transcriptional repressor IclR; Provisional; Region: PRK11569
438753001509	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
438753001510	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753001511	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
438753001512	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
438753001513	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753001514	DNA-binding site [nucleotide binding]; DNA binding site
438753001515	FCD domain; Region: FCD; pfam07729
438753001516	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
438753001517	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
438753001518	PYR/PP interface [polypeptide binding]; other site
438753001519	dimer interface [polypeptide binding]; other site
438753001520	TPP binding site [chemical binding]; other site
438753001521	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
438753001522	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
438753001523	TPP-binding site; other site
438753001524	dimer interface [polypeptide binding]; other site
438753001525	formyl-coenzyme A transferase; Provisional; Region: PRK05398
438753001526	CoA-transferase family III; Region: CoA_transf_3; pfam02515
438753001527	formyl-coenzyme A transferase; Provisional; Region: PRK05398
438753001528	CoA-transferase family III; Region: CoA_transf_3; pfam02515
438753001529	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
438753001530	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
438753001531	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
438753001532	ABC transporter ATPase component; Reviewed; Region: PRK11147
438753001533	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
438753001534	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
438753001535	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753001536	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753001537	DNA-binding site [nucleotide binding]; DNA binding site
438753001538	FCD domain; Region: FCD; pfam07729
438753001539	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
438753001540	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
438753001541	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753001542	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753001543	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753001544	Walker A/P-loop; other site
438753001545	ATP binding site [chemical binding]; other site
438753001546	Q-loop/lid; other site
438753001547	ABC transporter signature motif; other site
438753001548	Walker B; other site
438753001549	D-loop; other site
438753001550	H-loop/switch region; other site
438753001551	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753001552	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753001553	Walker A/P-loop; other site
438753001554	ATP binding site [chemical binding]; other site
438753001555	Q-loop/lid; other site
438753001556	ABC transporter signature motif; other site
438753001557	Walker B; other site
438753001558	D-loop; other site
438753001559	H-loop/switch region; other site
438753001560	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753001561	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753001562	TM-ABC transporter signature motif; other site
438753001563	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753001564	TM-ABC transporter signature motif; other site
438753001565	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
438753001566	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
438753001567	active site
438753001568	homotetramer interface [polypeptide binding]; other site
438753001569	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
438753001570	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
438753001571	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
438753001572	catalytic triad [active]
438753001573	dimer interface [polypeptide binding]; other site
438753001574	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
438753001575	hypothetical protein; Validated; Region: PRK00228
438753001576	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
438753001577	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753001578	PAS fold; Region: PAS_3; pfam08447
438753001579	putative active site [active]
438753001580	heme pocket [chemical binding]; other site
438753001581	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753001582	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753001583	metal binding site [ion binding]; metal-binding site
438753001584	active site
438753001585	I-site; other site
438753001586	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753001587	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
438753001588	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
438753001589	NAD(P) binding site [chemical binding]; other site
438753001590	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
438753001591	Protein of unknown function (DUF1465); Region: DUF1465; cl11562
438753001592	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
438753001593	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
438753001594	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
438753001595	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753001596	Walker A/P-loop; other site
438753001597	ATP binding site [chemical binding]; other site
438753001598	Q-loop/lid; other site
438753001599	ABC transporter signature motif; other site
438753001600	Walker B; other site
438753001601	D-loop; other site
438753001602	H-loop/switch region; other site
438753001603	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
438753001604	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753001605	Coenzyme A binding pocket [chemical binding]; other site
438753001606	hypothetical protein; Validated; Region: PRK09039
438753001607	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
438753001608	ligand binding site [chemical binding]; other site
438753001609	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
438753001610	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
438753001611	active site
438753001612	dimerization interface [polypeptide binding]; other site
438753001613	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
438753001614	Sel1-like repeats; Region: SEL1; smart00671
438753001615	Sel1-like repeats; Region: SEL1; smart00671
438753001616	Sel1-like repeats; Region: SEL1; smart00671
438753001617	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
438753001618	thiamine phosphate binding site [chemical binding]; other site
438753001619	active site
438753001620	pyrophosphate binding site [ion binding]; other site
438753001621	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
438753001622	active site
438753001623	intersubunit interface [polypeptide binding]; other site
438753001624	catalytic residue [active]
438753001625	Phosphoglycerate kinase; Region: PGK; pfam00162
438753001626	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
438753001627	substrate binding site [chemical binding]; other site
438753001628	hinge regions; other site
438753001629	ADP binding site [chemical binding]; other site
438753001630	catalytic site [active]
438753001631	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
438753001632	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
438753001633	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
438753001634	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
438753001635	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
438753001636	TPP-binding site [chemical binding]; other site
438753001637	dimer interface [polypeptide binding]; other site
438753001638	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
438753001639	PYR/PP interface [polypeptide binding]; other site
438753001640	dimer interface [polypeptide binding]; other site
438753001641	TPP binding site [chemical binding]; other site
438753001642	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
438753001643	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
438753001644	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
438753001645	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
438753001646	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
438753001647	putative active site [active]
438753001648	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
438753001649	metal binding site [ion binding]; metal-binding site
438753001650	homodimer binding site [polypeptide binding]; other site
438753001651	hypothetical protein; Validated; Region: PRK00110
438753001652	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
438753001653	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
438753001654	DNA binding residues [nucleotide binding]
438753001655	putative dimer interface [polypeptide binding]; other site
438753001656	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
438753001657	Sel1-like repeats; Region: SEL1; smart00671
438753001658	Sel1-like repeats; Region: SEL1; smart00671
438753001659	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
438753001660	active site
438753001661	putative DNA-binding cleft [nucleotide binding]; other site
438753001662	dimer interface [polypeptide binding]; other site
438753001663	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
438753001664	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
438753001665	RuvA N terminal domain; Region: RuvA_N; pfam01330
438753001666	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
438753001667	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
438753001668	GIY-YIG motif/motif A; other site
438753001669	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
438753001670	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753001671	Walker A motif; other site
438753001672	ATP binding site [chemical binding]; other site
438753001673	Walker B motif; other site
438753001674	arginine finger; other site
438753001675	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
438753001676	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
438753001677	active site
438753001678	TolQ protein; Region: tolQ; TIGR02796
438753001679	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
438753001680	TolR protein; Region: tolR; TIGR02801
438753001681	translocation protein TolB; Provisional; Region: tolB; PRK05137
438753001682	TolB amino-terminal domain; Region: TolB_N; pfam04052
438753001683	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
438753001684	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
438753001685	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
438753001686	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
438753001687	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
438753001688	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
438753001689	ligand binding site [chemical binding]; other site
438753001690	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
438753001691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753001692	binding surface
438753001693	TPR motif; other site
438753001694	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
438753001695	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
438753001696	Ligand Binding Site [chemical binding]; other site
438753001697	FtsH Extracellular; Region: FtsH_ext; pfam06480
438753001698	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
438753001699	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753001700	Walker A motif; other site
438753001701	ATP binding site [chemical binding]; other site
438753001702	Walker B motif; other site
438753001703	arginine finger; other site
438753001704	Peptidase family M41; Region: Peptidase_M41; pfam01434
438753001705	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
438753001706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753001707	S-adenosylmethionine binding site [chemical binding]; other site
438753001708	replicative DNA helicase; Provisional; Region: PRK09165
438753001709	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
438753001710	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
438753001711	Walker A motif; other site
438753001712	ATP binding site [chemical binding]; other site
438753001713	Walker B motif; other site
438753001714	DNA binding loops [nucleotide binding]
438753001715	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
438753001716	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
438753001717	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
438753001718	putative ligand binding site [chemical binding]; other site
438753001719	NAD binding site [chemical binding]; other site
438753001720	catalytic site [active]
438753001721	DNA repair protein RadA; Provisional; Region: PRK11823
438753001722	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
438753001723	Walker A motif/ATP binding site; other site
438753001724	ATP binding site [chemical binding]; other site
438753001725	Walker B motif; other site
438753001726	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
438753001727	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
438753001728	Colicin V production protein; Region: Colicin_V; pfam02674
438753001729	amidophosphoribosyltransferase; Provisional; Region: PRK09123
438753001730	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
438753001731	active site
438753001732	tetramer interface [polypeptide binding]; other site
438753001733	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
438753001734	active site
438753001735	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
438753001736	classical (c) SDRs; Region: SDR_c; cd05233
438753001737	NAD(P) binding site [chemical binding]; other site
438753001738	active site
438753001739	multifunctional aminopeptidase A; Provisional; Region: PRK00913
438753001740	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
438753001741	interface (dimer of trimers) [polypeptide binding]; other site
438753001742	Substrate-binding/catalytic site; other site
438753001743	Zn-binding sites [ion binding]; other site
438753001744	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
438753001745	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
438753001746	DNA polymerase III subunit chi; Validated; Region: PRK05728
438753001747	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
438753001748	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
438753001749	putative catalytic residue [active]
438753001750	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
438753001751	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
438753001752	Autotransporter beta-domain; Region: Autotransporter; pfam03797
438753001753	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
438753001754	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
438753001755	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
438753001756	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971
438753001757	active site
438753001758	acyl-activating enzyme (AAE) consensus motif; other site
438753001759	putative CoA binding site [chemical binding]; other site
438753001760	AMP binding site [chemical binding]; other site
438753001761	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
438753001762	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
438753001763	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
438753001764	Protein of unknown function (DUF1634); Region: DUF1634; cl01741
438753001765	Mechanosensitive ion channel; Region: MS_channel; pfam00924
438753001766	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
438753001767	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
438753001768	metal binding site [ion binding]; metal-binding site
438753001769	dimer interface [polypeptide binding]; other site
438753001770	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
438753001771	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
438753001772	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
438753001773	NADP binding site [chemical binding]; other site
438753001774	dimer interface [polypeptide binding]; other site
438753001775	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
438753001776	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
438753001777	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
438753001778	intracellular protease, PfpI family; Region: PfpI; TIGR01382
438753001779	proposed catalytic triad [active]
438753001780	conserved cys residue [active]
438753001781	aspartate aminotransferase; Provisional; Region: PRK05764
438753001782	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753001783	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753001784	homodimer interface [polypeptide binding]; other site
438753001785	catalytic residue [active]
438753001786	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
438753001787	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
438753001788	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
438753001789	substrate binding site [chemical binding]; other site
438753001790	ATP binding site [chemical binding]; other site
438753001791	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
438753001792	active site
438753001793	intersubunit interface [polypeptide binding]; other site
438753001794	catalytic residue [active]
438753001795	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
438753001796	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
438753001797	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
438753001798	ABC 3 transport family; Region: ABC-3; pfam00950
438753001799	ABC-ATPase subunit  interface; other site
438753001800	dimer interface [polypeptide binding]; other site
438753001801	putative PBP binding regions; other site
438753001802	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
438753001803	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
438753001804	metal binding site [ion binding]; metal-binding site
438753001805	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
438753001806	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
438753001807	P-loop, Walker A motif; other site
438753001808	Base recognition motif; other site
438753001809	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
438753001810	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
438753001811	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
438753001812	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
438753001813	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
438753001814	HIGH motif; other site
438753001815	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
438753001816	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
438753001817	active site
438753001818	KMSKS motif; other site
438753001819	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
438753001820	tRNA binding surface [nucleotide binding]; other site
438753001821	Lipopolysaccharide-assembly; Region: LptE; cl01125
438753001822	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
438753001823	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
438753001824	muropeptide transporter; Validated; Region: ampG; cl17669
438753001825	muropeptide transporter; Reviewed; Region: ampG; PRK11902
438753001826	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
438753001827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753001828	active site
438753001829	phosphorylation site [posttranslational modification]
438753001830	intermolecular recognition site; other site
438753001831	dimerization interface [polypeptide binding]; other site
438753001832	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
438753001833	DNA binding residues [nucleotide binding]
438753001834	dimerization interface [polypeptide binding]; other site
438753001835	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753001836	PAS domain; Region: PAS_9; pfam13426
438753001837	putative active site [active]
438753001838	heme pocket [chemical binding]; other site
438753001839	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753001840	PAS domain; Region: PAS_9; pfam13426
438753001841	putative active site [active]
438753001842	heme pocket [chemical binding]; other site
438753001843	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753001844	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753001845	dimer interface [polypeptide binding]; other site
438753001846	putative CheW interface [polypeptide binding]; other site
438753001847	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753001848	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753001849	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
438753001850	putative effector binding pocket; other site
438753001851	dimerization interface [polypeptide binding]; other site
438753001852	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
438753001853	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
438753001854	tetrameric interface [polypeptide binding]; other site
438753001855	NAD binding site [chemical binding]; other site
438753001856	catalytic residues [active]
438753001857	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
438753001858	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
438753001859	substrate binding pocket [chemical binding]; other site
438753001860	FAD binding site [chemical binding]; other site
438753001861	catalytic base [active]
438753001862	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
438753001863	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
438753001864	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
438753001865	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
438753001866	active site
438753001867	catalytic tetrad [active]
438753001868	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
438753001869	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
438753001870	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
438753001871	acyl-activating enzyme (AAE) consensus motif; other site
438753001872	acyl-activating enzyme (AAE) consensus motif; other site
438753001873	AMP binding site [chemical binding]; other site
438753001874	active site
438753001875	CoA binding site [chemical binding]; other site
438753001876	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753001877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753001878	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753001879	dimerization interface [polypeptide binding]; other site
438753001880	Predicted transcriptional regulators [Transcription]; Region: COG1510
438753001881	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753001882	dimerization interface [polypeptide binding]; other site
438753001883	putative DNA binding site [nucleotide binding]; other site
438753001884	putative Zn2+ binding site [ion binding]; other site
438753001885	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
438753001886	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
438753001887	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753001888	Walker A/P-loop; other site
438753001889	ATP binding site [chemical binding]; other site
438753001890	Q-loop/lid; other site
438753001891	ABC transporter signature motif; other site
438753001892	Walker B; other site
438753001893	D-loop; other site
438753001894	H-loop/switch region; other site
438753001895	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
438753001896	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753001897	Walker A/P-loop; other site
438753001898	ATP binding site [chemical binding]; other site
438753001899	Q-loop/lid; other site
438753001900	ABC transporter signature motif; other site
438753001901	Walker B; other site
438753001902	D-loop; other site
438753001903	H-loop/switch region; other site
438753001904	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
438753001905	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
438753001906	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
438753001907	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
438753001908	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
438753001909	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
438753001910	PhnA protein; Region: PhnA; pfam03831
438753001911	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
438753001912	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753001913	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
438753001914	putative ligand binding site [chemical binding]; other site
438753001915	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
438753001916	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
438753001917	Putative cyclase; Region: Cyclase; pfam04199
438753001918	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753001919	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753001920	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753001921	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
438753001922	putative active site [active]
438753001923	heme pocket [chemical binding]; other site
438753001924	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753001925	dimer interface [polypeptide binding]; other site
438753001926	phosphorylation site [posttranslational modification]
438753001927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753001928	ATP binding site [chemical binding]; other site
438753001929	Mg2+ binding site [ion binding]; other site
438753001930	G-X-G motif; other site
438753001931	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
438753001932	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
438753001933	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
438753001934	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
438753001935	Acylphosphatase; Region: Acylphosphatase; pfam00708
438753001936	HypF finger; Region: zf-HYPF; pfam07503
438753001937	HypF finger; Region: zf-HYPF; pfam07503
438753001938	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
438753001939	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
438753001940	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
438753001941	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
438753001942	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
438753001943	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
438753001944	Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125
438753001945	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
438753001946	putative substrate-binding site; other site
438753001947	nickel binding site [ion binding]; other site
438753001948	HupF/HypC family; Region: HupF_HypC; pfam01455
438753001949	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
438753001950	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
438753001951	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
438753001952	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
438753001953	Rubredoxin; Region: Rubredoxin; pfam00301
438753001954	iron binding site [ion binding]; other site
438753001955	Protein of unknown function (DUF3457); Region: DUF3457; pfam11939
438753001956	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
438753001957	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
438753001958	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
438753001959	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
438753001960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753001961	active site
438753001962	phosphorylation site [posttranslational modification]
438753001963	intermolecular recognition site; other site
438753001964	dimerization interface [polypeptide binding]; other site
438753001965	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753001966	Walker A motif; other site
438753001967	ATP binding site [chemical binding]; other site
438753001968	Walker B motif; other site
438753001969	arginine finger; other site
438753001970	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
438753001971	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298
438753001972	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
438753001973	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
438753001974	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
438753001975	dimerization interface [polypeptide binding]; other site
438753001976	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
438753001977	ATP binding site [chemical binding]; other site
438753001978	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
438753001979	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
438753001980	PAS domain; Region: PAS; smart00091
438753001981	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
438753001982	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753001983	dimer interface [polypeptide binding]; other site
438753001984	phosphorylation site [posttranslational modification]
438753001985	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753001986	ATP binding site [chemical binding]; other site
438753001987	Mg2+ binding site [ion binding]; other site
438753001988	G-X-G motif; other site
438753001989	Response regulator receiver domain; Region: Response_reg; pfam00072
438753001990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753001991	active site
438753001992	phosphorylation site [posttranslational modification]
438753001993	intermolecular recognition site; other site
438753001994	dimerization interface [polypeptide binding]; other site
438753001995	Response regulator receiver domain; Region: Response_reg; pfam00072
438753001996	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753001997	active site
438753001998	phosphorylation site [posttranslational modification]
438753001999	intermolecular recognition site; other site
438753002000	dimerization interface [polypeptide binding]; other site
438753002001	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753002002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753002003	active site
438753002004	phosphorylation site [posttranslational modification]
438753002005	intermolecular recognition site; other site
438753002006	dimerization interface [polypeptide binding]; other site
438753002007	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
438753002008	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
438753002009	DNA binding site [nucleotide binding]
438753002010	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
438753002011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753002012	active site
438753002013	phosphorylation site [posttranslational modification]
438753002014	intermolecular recognition site; other site
438753002015	dimerization interface [polypeptide binding]; other site
438753002016	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
438753002017	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
438753002018	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
438753002019	N-acetyl-D-glucosamine binding site [chemical binding]; other site
438753002020	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
438753002021	chemotaxis protein; Reviewed; Region: PRK12798
438753002022	flagellar motor protein MotB; Validated; Region: motB; PRK05996
438753002023	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
438753002024	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
438753002025	ligand binding site [chemical binding]; other site
438753002026	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
438753002027	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
438753002028	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
438753002029	FliP family; Region: FliP; cl00593
438753002030	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
438753002031	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
438753002032	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788
438753002033	Uncharacterized conserved protein [Function unknown]; Region: COG3334
438753002034	flagellar basal body P-ring protein; Reviewed; Region: flgI; PRK12789
438753002035	Flagellar P-ring protein; Region: FlgI; pfam02119
438753002036	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
438753002037	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
438753002038	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12692
438753002039	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
438753002040	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
438753002041	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
438753002042	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
438753002043	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
438753002044	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
438753002045	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK13109
438753002046	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
438753002047	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
438753002048	FliG C-terminal domain; Region: FliG_C; pfam01706
438753002049	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
438753002050	Flagellar motor switch protein FliM; Region: FliM; pfam02154
438753002051	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
438753002052	flagellar motor protein MotA; Validated; Region: PRK09110
438753002053	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
438753002054	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
438753002055	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
438753002056	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
438753002057	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
438753002058	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
438753002059	Walker A motif; other site
438753002060	ATP binding site [chemical binding]; other site
438753002061	Walker B motif; other site
438753002062	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
438753002063	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
438753002064	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
438753002065	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
438753002066	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
438753002067	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
438753002068	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
438753002069	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
438753002070	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
438753002071	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
438753002072	Flagellar protein FlaF; Region: FlaF; pfam07309
438753002073	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794
438753002074	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
438753002075	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
438753002076	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
438753002077	flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792
438753002078	FHIPEP family; Region: FHIPEP; pfam00771
438753002079	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK12780
438753002080	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753002081	dimerization interface [polypeptide binding]; other site
438753002082	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753002083	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753002084	dimer interface [polypeptide binding]; other site
438753002085	putative CheW interface [polypeptide binding]; other site
438753002086	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
438753002087	putative binding surface; other site
438753002088	active site
438753002089	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
438753002090	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
438753002091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753002092	ATP binding site [chemical binding]; other site
438753002093	Mg2+ binding site [ion binding]; other site
438753002094	G-X-G motif; other site
438753002095	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
438753002096	CheW-like domain; Region: CheW; pfam01584
438753002097	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
438753002098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753002099	active site
438753002100	phosphorylation site [posttranslational modification]
438753002101	intermolecular recognition site; other site
438753002102	dimerization interface [polypeptide binding]; other site
438753002103	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
438753002104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753002105	Response regulator receiver domain; Region: Response_reg; pfam00072
438753002106	active site
438753002107	phosphorylation site [posttranslational modification]
438753002108	intermolecular recognition site; other site
438753002109	dimerization interface [polypeptide binding]; other site
438753002110	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
438753002111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753002112	active site
438753002113	phosphorylation site [posttranslational modification]
438753002114	intermolecular recognition site; other site
438753002115	dimerization interface [polypeptide binding]; other site
438753002116	CheB methylesterase; Region: CheB_methylest; pfam01339
438753002117	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
438753002118	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
438753002119	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
438753002120	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
438753002121	heme-binding site [chemical binding]; other site
438753002122	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753002123	dimer interface [polypeptide binding]; other site
438753002124	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
438753002125	putative CheW interface [polypeptide binding]; other site
438753002126	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
438753002127	active site
438753002128	Predicted membrane protein [Function unknown]; Region: COG2855
438753002129	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
438753002130	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753002131	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
438753002132	putative dimerization interface [polypeptide binding]; other site
438753002133	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
438753002134	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
438753002135	methionine sulfoxide reductase A; Provisional; Region: PRK00058
438753002136	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
438753002137	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753002138	Coenzyme A binding pocket [chemical binding]; other site
438753002139	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
438753002140	dimer interface [polypeptide binding]; other site
438753002141	substrate binding site [chemical binding]; other site
438753002142	metal binding sites [ion binding]; metal-binding site
438753002143	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
438753002144	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
438753002145	[4Fe-4S] binding site [ion binding]; other site
438753002146	molybdopterin cofactor binding site; other site
438753002147	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
438753002148	molybdopterin cofactor binding site; other site
438753002149	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
438753002150	sulfite reductase; Provisional; Region: PRK06214
438753002151	Putative Fe-S cluster; Region: FeS; cl17515
438753002152	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
438753002153	FAD binding pocket [chemical binding]; other site
438753002154	FAD binding motif [chemical binding]; other site
438753002155	catalytic residues [active]
438753002156	NAD binding pocket [chemical binding]; other site
438753002157	phosphate binding motif [ion binding]; other site
438753002158	beta-alpha-beta structure motif; other site
438753002159	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567
438753002160	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
438753002161	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
438753002162	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
438753002163	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
438753002164	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
438753002165	heme-binding site [chemical binding]; other site
438753002166	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753002167	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753002168	Walker A/P-loop; other site
438753002169	ATP binding site [chemical binding]; other site
438753002170	Q-loop/lid; other site
438753002171	ABC transporter signature motif; other site
438753002172	Walker B; other site
438753002173	D-loop; other site
438753002174	H-loop/switch region; other site
438753002175	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753002176	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753002177	putative PBP binding loops; other site
438753002178	dimer interface [polypeptide binding]; other site
438753002179	ABC-ATPase subunit interface; other site
438753002180	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
438753002181	NMT1-like family; Region: NMT1_2; pfam13379
438753002182	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
438753002183	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
438753002184	tetramer interface [polypeptide binding]; other site
438753002185	active site
438753002186	Mg2+/Mn2+ binding site [ion binding]; other site
438753002187	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
438753002188	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
438753002189	chaperone protein DnaJ; Provisional; Region: PRK10767
438753002190	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
438753002191	HSP70 interaction site [polypeptide binding]; other site
438753002192	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
438753002193	substrate binding site [polypeptide binding]; other site
438753002194	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
438753002195	Zn binding sites [ion binding]; other site
438753002196	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
438753002197	dimer interface [polypeptide binding]; other site
438753002198	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
438753002199	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
438753002200	nucleotide binding site [chemical binding]; other site
438753002201	NEF interaction site [polypeptide binding]; other site
438753002202	SBD interface [polypeptide binding]; other site
438753002203	NMT1-like family; Region: NMT1_2; pfam13379
438753002204	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
438753002205	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
438753002206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
438753002207	active site
438753002208	phosphorylation site [posttranslational modification]
438753002209	intermolecular recognition site; other site
438753002210	ANTAR domain; Region: ANTAR; pfam03861
438753002211	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
438753002212	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
438753002213	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753002214	Coenzyme A binding pocket [chemical binding]; other site
438753002215	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753002216	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753002217	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
438753002218	putative effector binding pocket; other site
438753002219	dimerization interface [polypeptide binding]; other site
438753002220	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
438753002221	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
438753002222	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
438753002223	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
438753002224	dimer interface [polypeptide binding]; other site
438753002225	PYR/PP interface [polypeptide binding]; other site
438753002226	TPP binding site [chemical binding]; other site
438753002227	substrate binding site [chemical binding]; other site
438753002228	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
438753002229	TPP-binding site [chemical binding]; other site
438753002230	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
438753002231	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
438753002232	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
438753002233	active site
438753002234	motif I; other site
438753002235	motif II; other site
438753002236	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
438753002237	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
438753002238	feedback inhibition sensing region; other site
438753002239	homohexameric interface [polypeptide binding]; other site
438753002240	nucleotide binding site [chemical binding]; other site
438753002241	N-acetyl-L-glutamate binding site [chemical binding]; other site
438753002242	Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304
438753002243	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
438753002244	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753002245	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753002246	active site
438753002247	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
438753002248	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
438753002249	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
438753002250	trimer interface [polypeptide binding]; other site
438753002251	active site
438753002252	substrate binding site [chemical binding]; other site
438753002253	CoA binding site [chemical binding]; other site
438753002254	KpsF/GutQ family protein; Region: kpsF; TIGR00393
438753002255	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
438753002256	putative active site [active]
438753002257	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
438753002258	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
438753002259	trimer interface [polypeptide binding]; other site
438753002260	active site
438753002261	Rrf2 family protein; Region: rrf2_super; TIGR00738
438753002262	Transcriptional regulator; Region: Rrf2; pfam02082
438753002263	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
438753002264	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
438753002265	dimer interface [polypeptide binding]; other site
438753002266	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753002267	catalytic residue [active]
438753002268	PAS fold; Region: PAS_7; pfam12860
438753002269	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
438753002270	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753002271	dimer interface [polypeptide binding]; other site
438753002272	phosphorylation site [posttranslational modification]
438753002273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753002274	ATP binding site [chemical binding]; other site
438753002275	Mg2+ binding site [ion binding]; other site
438753002276	G-X-G motif; other site
438753002277	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
438753002278	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
438753002279	Phosphotransferase enzyme family; Region: APH; pfam01636
438753002280	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
438753002281	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
438753002282	Substrate binding site; other site
438753002283	metal-binding site
438753002284	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
438753002285	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
438753002286	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
438753002287	Part of AAA domain; Region: AAA_19; pfam13245
438753002288	Family description; Region: UvrD_C_2; pfam13538
438753002289	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
438753002290	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
438753002291	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
438753002292	catalytic residues [active]
438753002293	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
438753002294	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
438753002295	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
438753002296	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753002297	dimerization interface [polypeptide binding]; other site
438753002298	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753002299	dimer interface [polypeptide binding]; other site
438753002300	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
438753002301	putative CheW interface [polypeptide binding]; other site
438753002302	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753002303	Amidase; Region: Amidase; cl11426
438753002304	pyruvate dehydrogenase; Provisional; Region: PRK09124
438753002305	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
438753002306	PYR/PP interface [polypeptide binding]; other site
438753002307	dimer interface [polypeptide binding]; other site
438753002308	tetramer interface [polypeptide binding]; other site
438753002309	TPP binding site [chemical binding]; other site
438753002310	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
438753002311	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
438753002312	TPP-binding site [chemical binding]; other site
438753002313	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
438753002314	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753002315	dimerization interface [polypeptide binding]; other site
438753002316	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753002317	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753002318	dimer interface [polypeptide binding]; other site
438753002319	putative CheW interface [polypeptide binding]; other site
438753002320	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753002321	dimerization interface [polypeptide binding]; other site
438753002322	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
438753002323	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753002324	dimer interface [polypeptide binding]; other site
438753002325	putative CheW interface [polypeptide binding]; other site
438753002326	HAMP domain; Region: HAMP; pfam00672
438753002327	dimerization interface [polypeptide binding]; other site
438753002328	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753002329	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753002330	dimer interface [polypeptide binding]; other site
438753002331	putative CheW interface [polypeptide binding]; other site
438753002332	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753002333	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753002334	Walker A/P-loop; other site
438753002335	ATP binding site [chemical binding]; other site
438753002336	Q-loop/lid; other site
438753002337	ABC transporter signature motif; other site
438753002338	Walker B; other site
438753002339	D-loop; other site
438753002340	H-loop/switch region; other site
438753002341	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753002342	substrate binding pocket [chemical binding]; other site
438753002343	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753002344	membrane-bound complex binding site; other site
438753002345	hinge residues; other site
438753002346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753002347	dimer interface [polypeptide binding]; other site
438753002348	ABC-ATPase subunit interface; other site
438753002349	putative PBP binding loops; other site
438753002350	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
438753002351	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
438753002352	inhibitor-cofactor binding pocket; inhibition site
438753002353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753002354	catalytic residue [active]
438753002355	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
438753002356	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753002357	DNA-binding site [nucleotide binding]; DNA binding site
438753002358	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753002359	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753002360	homodimer interface [polypeptide binding]; other site
438753002361	catalytic residue [active]
438753002362	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
438753002363	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
438753002364	inhibitor site; inhibition site
438753002365	active site
438753002366	dimer interface [polypeptide binding]; other site
438753002367	catalytic residue [active]
438753002368	short chain dehydrogenase; Provisional; Region: PRK12937
438753002369	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
438753002370	NADP binding site [chemical binding]; other site
438753002371	homodimer interface [polypeptide binding]; other site
438753002372	active site
438753002373	substrate binding site [chemical binding]; other site
438753002374	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
438753002375	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
438753002376	dimer interface [polypeptide binding]; other site
438753002377	active site
438753002378	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
438753002379	substrate binding site [chemical binding]; other site
438753002380	catalytic residue [active]
438753002381	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
438753002382	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753002383	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753002384	hypothetical protein; Provisional; Region: PRK06184
438753002385	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
438753002386	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
438753002387	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
438753002388	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
438753002389	HAMP domain; Region: HAMP; pfam00672
438753002390	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753002391	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753002392	metal binding site [ion binding]; metal-binding site
438753002393	active site
438753002394	I-site; other site
438753002395	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
438753002396	MarR family; Region: MarR; pfam01047
438753002397	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753002398	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
438753002399	putative substrate translocation pore; other site
438753002400	argininosuccinate synthase; Provisional; Region: PRK13820
438753002401	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
438753002402	ANP binding site [chemical binding]; other site
438753002403	Substrate Binding Site II [chemical binding]; other site
438753002404	Substrate Binding Site I [chemical binding]; other site
438753002405	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
438753002406	active site
438753002407	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
438753002408	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
438753002409	putative catalytic residue [active]
438753002410	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
438753002411	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753002412	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
438753002413	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753002414	FeS/SAM binding site; other site
438753002415	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
438753002416	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
438753002417	NAD(P) binding site [chemical binding]; other site
438753002418	Uncharacterized conserved protein [Function unknown]; Region: COG3339
438753002419	Family of unknown function (DUF490); Region: DUF490; pfam04357
438753002420	Family of unknown function (DUF490); Region: DUF490; pfam04357
438753002421	Family of unknown function (DUF490); Region: DUF490; pfam04357
438753002422	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
438753002423	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
438753002424	Surface antigen; Region: Bac_surface_Ag; pfam01103
438753002425	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
438753002426	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
438753002427	NAD binding site [chemical binding]; other site
438753002428	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753002429	PAS domain; Region: PAS_9; pfam13426
438753002430	putative active site [active]
438753002431	heme pocket [chemical binding]; other site
438753002432	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753002433	PAS domain; Region: PAS_9; pfam13426
438753002434	putative active site [active]
438753002435	heme pocket [chemical binding]; other site
438753002436	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
438753002437	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753002438	Walker A motif; other site
438753002439	ATP binding site [chemical binding]; other site
438753002440	Walker B motif; other site
438753002441	arginine finger; other site
438753002442	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
438753002443	NMT1-like family; Region: NMT1_2; pfam13379
438753002444	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753002445	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753002446	dimer interface [polypeptide binding]; other site
438753002447	conserved gate region; other site
438753002448	putative PBP binding loops; other site
438753002449	ABC-ATPase subunit interface; other site
438753002450	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753002451	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753002452	Walker A/P-loop; other site
438753002453	ATP binding site [chemical binding]; other site
438753002454	Q-loop/lid; other site
438753002455	ABC transporter signature motif; other site
438753002456	Walker B; other site
438753002457	D-loop; other site
438753002458	H-loop/switch region; other site
438753002459	cyanate hydratase; Validated; Region: PRK02866
438753002460	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
438753002461	oligomer interface [polypeptide binding]; other site
438753002462	active site
438753002463	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
438753002464	Transcriptional regulator [Transcription]; Region: IclR; COG1414
438753002465	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753002466	succinic semialdehyde dehydrogenase; Region: PLN02278
438753002467	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
438753002468	tetramerization interface [polypeptide binding]; other site
438753002469	NAD(P) binding site [chemical binding]; other site
438753002470	catalytic residues [active]
438753002471	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
438753002472	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
438753002473	putative active site [active]
438753002474	metal binding site [ion binding]; metal-binding site
438753002475	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
438753002476	benzoate transport; Region: 2A0115; TIGR00895
438753002477	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753002478	putative substrate translocation pore; other site
438753002479	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753002480	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
438753002481	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
438753002482	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753002483	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753002484	DNA-binding site [nucleotide binding]; DNA binding site
438753002485	FCD domain; Region: FCD; pfam07729
438753002486	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
438753002487	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
438753002488	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
438753002489	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753002490	Walker A/P-loop; other site
438753002491	ATP binding site [chemical binding]; other site
438753002492	Q-loop/lid; other site
438753002493	ABC transporter signature motif; other site
438753002494	Walker B; other site
438753002495	D-loop; other site
438753002496	H-loop/switch region; other site
438753002497	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753002498	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
438753002499	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753002500	Walker A/P-loop; other site
438753002501	ATP binding site [chemical binding]; other site
438753002502	Q-loop/lid; other site
438753002503	ABC transporter signature motif; other site
438753002504	Walker B; other site
438753002505	D-loop; other site
438753002506	H-loop/switch region; other site
438753002507	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753002508	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
438753002509	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
438753002510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753002511	putative PBP binding loops; other site
438753002512	dimer interface [polypeptide binding]; other site
438753002513	ABC-ATPase subunit interface; other site
438753002514	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753002515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753002516	dimer interface [polypeptide binding]; other site
438753002517	conserved gate region; other site
438753002518	putative PBP binding loops; other site
438753002519	ABC-ATPase subunit interface; other site
438753002520	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511
438753002521	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
438753002522	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753002523	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511
438753002524	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
438753002525	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
438753002526	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
438753002527	ligand binding site [chemical binding]; other site
438753002528	Transcriptional regulators [Transcription]; Region: PurR; COG1609
438753002529	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
438753002530	DNA binding site [nucleotide binding]
438753002531	domain linker motif; other site
438753002532	Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282
438753002533	putative dimerization interface [polypeptide binding]; other site
438753002534	putative ligand binding site [chemical binding]; other site
438753002535	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
438753002536	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
438753002537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753002538	dimer interface [polypeptide binding]; other site
438753002539	conserved gate region; other site
438753002540	ABC-ATPase subunit interface; other site
438753002541	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
438753002542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753002543	putative PBP binding loops; other site
438753002544	dimer interface [polypeptide binding]; other site
438753002545	ABC-ATPase subunit interface; other site
438753002546	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
438753002547	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753002548	Walker A/P-loop; other site
438753002549	ATP binding site [chemical binding]; other site
438753002550	Q-loop/lid; other site
438753002551	ABC transporter signature motif; other site
438753002552	Walker B; other site
438753002553	D-loop; other site
438753002554	H-loop/switch region; other site
438753002555	TOBE domain; Region: TOBE_2; pfam08402
438753002556	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
438753002557	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
438753002558	active site
438753002559	metal binding site [ion binding]; metal-binding site
438753002560	hexamer interface [polypeptide binding]; other site
438753002561	allantoate amidohydrolase; Reviewed; Region: PRK09290
438753002562	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
438753002563	active site
438753002564	metal binding site [ion binding]; metal-binding site
438753002565	dimer interface [polypeptide binding]; other site
438753002566	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
438753002567	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
438753002568	active site
438753002569	catalytic site [active]
438753002570	tetramer interface [polypeptide binding]; other site
438753002571	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
438753002572	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
438753002573	active site
438753002574	homotetramer interface [polypeptide binding]; other site
438753002575	xanthine permease; Region: pbuX; TIGR03173
438753002576	transcriptional regulator; Provisional; Region: PRK10632
438753002577	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753002578	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
438753002579	putative effector binding pocket; other site
438753002580	dimerization interface [polypeptide binding]; other site
438753002581	Predicted membrane protein [Function unknown]; Region: COG3748
438753002582	Protein of unknown function (DUF989); Region: DUF989; pfam06181
438753002583	Cytochrome c; Region: Cytochrom_C; pfam00034
438753002584	M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697
438753002585	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
438753002586	putative metal binding site [ion binding]; other site
438753002587	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753002588	dimerization interface [polypeptide binding]; other site
438753002589	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753002590	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753002591	dimer interface [polypeptide binding]; other site
438753002592	putative CheW interface [polypeptide binding]; other site
438753002593	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
438753002594	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
438753002595	dimerization interface 3.5A [polypeptide binding]; other site
438753002596	active site
438753002597	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
438753002598	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
438753002599	putative active site [active]
438753002600	substrate binding site [chemical binding]; other site
438753002601	putative cosubstrate binding site; other site
438753002602	catalytic site [active]
438753002603	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
438753002604	substrate binding site [chemical binding]; other site
438753002605	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
438753002606	active site
438753002607	catalytic residues [active]
438753002608	metal binding site [ion binding]; metal-binding site
438753002609	RmuC family; Region: RmuC; pfam02646
438753002610	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
438753002611	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
438753002612	DNA binding site [nucleotide binding]
438753002613	catalytic residue [active]
438753002614	H2TH interface [polypeptide binding]; other site
438753002615	putative catalytic residues [active]
438753002616	turnover-facilitating residue; other site
438753002617	intercalation triad [nucleotide binding]; other site
438753002618	8OG recognition residue [nucleotide binding]; other site
438753002619	putative reading head residues; other site
438753002620	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
438753002621	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
438753002622	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
438753002623	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
438753002624	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
438753002625	putative acyl-acceptor binding pocket; other site
438753002626	enoyl-CoA hydratase; Provisional; Region: PRK05862
438753002627	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
438753002628	substrate binding site [chemical binding]; other site
438753002629	oxyanion hole (OAH) forming residues; other site
438753002630	trimer interface [polypeptide binding]; other site
438753002631	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
438753002632	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
438753002633	Uncharacterized conserved protein [Function unknown]; Region: COG1284
438753002634	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
438753002635	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
438753002636	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
438753002637	metal binding site [ion binding]; metal-binding site
438753002638	dimer interface [polypeptide binding]; other site
438753002639	hypothetical protein; Provisional; Region: PRK07079
438753002640	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
438753002641	metal binding site [ion binding]; metal-binding site
438753002642	putative dimer interface [polypeptide binding]; other site
438753002643	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
438753002644	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753002645	Walker A/P-loop; other site
438753002646	ATP binding site [chemical binding]; other site
438753002647	Q-loop/lid; other site
438753002648	ABC transporter signature motif; other site
438753002649	Walker B; other site
438753002650	D-loop; other site
438753002651	H-loop/switch region; other site
438753002652	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753002653	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
438753002654	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753002655	Walker A/P-loop; other site
438753002656	ATP binding site [chemical binding]; other site
438753002657	Q-loop/lid; other site
438753002658	ABC transporter signature motif; other site
438753002659	Walker B; other site
438753002660	D-loop; other site
438753002661	H-loop/switch region; other site
438753002662	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753002663	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
438753002664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753002665	dimer interface [polypeptide binding]; other site
438753002666	conserved gate region; other site
438753002667	putative PBP binding loops; other site
438753002668	ABC-ATPase subunit interface; other site
438753002669	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753002670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753002671	dimer interface [polypeptide binding]; other site
438753002672	conserved gate region; other site
438753002673	putative PBP binding loops; other site
438753002674	ABC-ATPase subunit interface; other site
438753002675	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753002676	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515
438753002677	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753002678	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753002679	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753002680	dimerization interface [polypeptide binding]; other site
438753002681	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
438753002682	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753002683	putative DNA binding site [nucleotide binding]; other site
438753002684	putative Zn2+ binding site [ion binding]; other site
438753002685	AsnC family; Region: AsnC_trans_reg; pfam01037
438753002686	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
438753002687	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
438753002688	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753002689	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753002690	substrate binding pocket [chemical binding]; other site
438753002691	membrane-bound complex binding site; other site
438753002692	hinge residues; other site
438753002693	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753002694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753002695	dimer interface [polypeptide binding]; other site
438753002696	conserved gate region; other site
438753002697	putative PBP binding loops; other site
438753002698	ABC-ATPase subunit interface; other site
438753002699	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753002700	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753002701	Walker A/P-loop; other site
438753002702	ATP binding site [chemical binding]; other site
438753002703	Q-loop/lid; other site
438753002704	ABC transporter signature motif; other site
438753002705	Walker B; other site
438753002706	D-loop; other site
438753002707	H-loop/switch region; other site
438753002708	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
438753002709	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
438753002710	metal binding site [ion binding]; metal-binding site
438753002711	substrate binding pocket [chemical binding]; other site
438753002712	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
438753002713	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
438753002714	hydroxyglutarate oxidase; Provisional; Region: PRK11728
438753002715	Cache domain; Region: Cache_1; pfam02743
438753002716	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753002717	dimerization interface [polypeptide binding]; other site
438753002718	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753002719	dimer interface [polypeptide binding]; other site
438753002720	putative CheW interface [polypeptide binding]; other site
438753002721	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
438753002722	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
438753002723	active site
438753002724	substrate binding site [chemical binding]; other site
438753002725	FMN binding site [chemical binding]; other site
438753002726	putative catalytic residues [active]
438753002727	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753002728	DNA-binding site [nucleotide binding]; DNA binding site
438753002729	FCD domain; Region: FCD; pfam07729
438753002730	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
438753002731	short chain dehydrogenase; Provisional; Region: PRK06701
438753002732	NAD binding site [chemical binding]; other site
438753002733	metal binding site [ion binding]; metal-binding site
438753002734	active site
438753002735	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
438753002736	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
438753002737	NAD binding site [chemical binding]; other site
438753002738	catalytic Zn binding site [ion binding]; other site
438753002739	structural Zn binding site [ion binding]; other site
438753002740	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
438753002741	active site
438753002742	DNA binding site [nucleotide binding]
438753002743	Int/Topo IB signature motif; other site
438753002744	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753002745	non-specific DNA binding site [nucleotide binding]; other site
438753002746	salt bridge; other site
438753002747	sequence-specific DNA binding site [nucleotide binding]; other site
438753002748	replicative DNA helicase; Region: DnaB; TIGR00665
438753002749	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
438753002750	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
438753002751	Walker A motif; other site
438753002752	ATP binding site [chemical binding]; other site
438753002753	Walker B motif; other site
438753002754	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
438753002755	Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565
438753002756	Terminase-like family; Region: Terminase_6; pfam03237
438753002757	Protein of unknown function (DUF4043); Region: DUF4043; pfam13252
438753002758	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
438753002759	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
438753002760	N-acetyl-D-glucosamine binding site [chemical binding]; other site
438753002761	catalytic residue [active]
438753002762	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
438753002763	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
438753002764	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
438753002765	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
438753002766	Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600
438753002767	Arc-like DNA binding domain; Region: Arc; pfam03869
438753002768	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
438753002769	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
438753002770	mannonate dehydratase; Provisional; Region: PRK03906
438753002771	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
438753002772	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753002773	non-specific DNA binding site [nucleotide binding]; other site
438753002774	salt bridge; other site
438753002775	sequence-specific DNA binding site [nucleotide binding]; other site
438753002776	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
438753002777	CsbD-like; Region: CsbD; pfam05532
438753002778	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
438753002779	active site
438753002780	Zn binding site [ion binding]; other site
438753002781	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753002782	putative substrate translocation pore; other site
438753002783	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
438753002784	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
438753002785	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
438753002786	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
438753002787	elongation factor Tu; Reviewed; Region: PRK00049
438753002788	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
438753002789	G1 box; other site
438753002790	GEF interaction site [polypeptide binding]; other site
438753002791	GTP/Mg2+ binding site [chemical binding]; other site
438753002792	Switch I region; other site
438753002793	G2 box; other site
438753002794	G3 box; other site
438753002795	Switch II region; other site
438753002796	G4 box; other site
438753002797	G5 box; other site
438753002798	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
438753002799	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
438753002800	Antibiotic Binding Site [chemical binding]; other site
438753002801	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
438753002802	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
438753002803	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
438753002804	putative homodimer interface [polypeptide binding]; other site
438753002805	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
438753002806	heterodimer interface [polypeptide binding]; other site
438753002807	homodimer interface [polypeptide binding]; other site
438753002808	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
438753002809	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
438753002810	23S rRNA interface [nucleotide binding]; other site
438753002811	L7/L12 interface [polypeptide binding]; other site
438753002812	putative thiostrepton binding site; other site
438753002813	L25 interface [polypeptide binding]; other site
438753002814	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
438753002815	mRNA/rRNA interface [nucleotide binding]; other site
438753002816	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
438753002817	23S rRNA interface [nucleotide binding]; other site
438753002818	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
438753002819	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
438753002820	L11 interface [polypeptide binding]; other site
438753002821	putative EF-Tu interaction site [polypeptide binding]; other site
438753002822	putative EF-G interaction site [polypeptide binding]; other site
438753002823	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
438753002824	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
438753002825	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
438753002826	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
438753002827	RPB11 interaction site [polypeptide binding]; other site
438753002828	RPB12 interaction site [polypeptide binding]; other site
438753002829	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
438753002830	RPB3 interaction site [polypeptide binding]; other site
438753002831	RPB1 interaction site [polypeptide binding]; other site
438753002832	RPB11 interaction site [polypeptide binding]; other site
438753002833	RPB10 interaction site [polypeptide binding]; other site
438753002834	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
438753002835	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
438753002836	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
438753002837	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
438753002838	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
438753002839	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
438753002840	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
438753002841	Peptidase family M23; Region: Peptidase_M23; pfam01551
438753002842	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
438753002843	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
438753002844	DNA binding site [nucleotide binding]
438753002845	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
438753002846	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
438753002847	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
438753002848	DNA binding residues [nucleotide binding]
438753002849	dimerization interface [polypeptide binding]; other site
438753002850	formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126
438753002851	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
438753002852	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
438753002853	putative active site [active]
438753002854	putative metal binding site [ion binding]; other site
438753002855	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
438753002856	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753002857	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753002858	putative substrate translocation pore; other site
438753002859	Glycosyltransferase WbsX; Region: Glyco_tran_WbsX; pfam14307
438753002860	Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754
438753002861	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
438753002862	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
438753002863	Potassium binding sites [ion binding]; other site
438753002864	Cesium cation binding sites [ion binding]; other site
438753002865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
438753002866	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
438753002867	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753002868	FeS/SAM binding site; other site
438753002869	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
438753002870	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
438753002871	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
438753002872	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
438753002873	tandem repeat interface [polypeptide binding]; other site
438753002874	oligomer interface [polypeptide binding]; other site
438753002875	active site residues [active]
438753002876	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
438753002877	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
438753002878	Methyltransferase domain; Region: Methyltransf_26; pfam13659
438753002879	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
438753002880	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
438753002881	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
438753002882	substrate binding pocket [chemical binding]; other site
438753002883	chain length determination region; other site
438753002884	substrate-Mg2+ binding site; other site
438753002885	catalytic residues [active]
438753002886	aspartate-rich region 1; other site
438753002887	active site lid residues [active]
438753002888	aspartate-rich region 2; other site
438753002889	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
438753002890	dimerization interface [polypeptide binding]; other site
438753002891	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753002892	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753002893	dimer interface [polypeptide binding]; other site
438753002894	putative CheW interface [polypeptide binding]; other site
438753002895	hypothetical protein; Provisional; Region: PRK02237
438753002896	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
438753002897	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
438753002898	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753002899	binding surface
438753002900	TPR motif; other site
438753002901	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753002902	binding surface
438753002903	TPR motif; other site
438753002904	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753002905	binding surface
438753002906	TPR motif; other site
438753002907	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753002908	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753002909	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753002910	dimerization interface [polypeptide binding]; other site
438753002911	NAD synthetase; Provisional; Region: PRK13981
438753002912	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
438753002913	multimer interface [polypeptide binding]; other site
438753002914	active site
438753002915	catalytic triad [active]
438753002916	protein interface 1 [polypeptide binding]; other site
438753002917	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
438753002918	homodimer interface [polypeptide binding]; other site
438753002919	NAD binding pocket [chemical binding]; other site
438753002920	ATP binding pocket [chemical binding]; other site
438753002921	Mg binding site [ion binding]; other site
438753002922	active-site loop [active]
438753002923	HD domain; Region: HD_5; pfam13487
438753002924	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
438753002925	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
438753002926	Zn2+ binding site [ion binding]; other site
438753002927	Mg2+ binding site [ion binding]; other site
438753002928	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
438753002929	GAF domain; Region: GAF; pfam01590
438753002930	Phytochrome region; Region: PHY; pfam00360
438753002931	HWE histidine kinase; Region: HWE_HK; pfam07536
438753002932	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
438753002933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753002934	phosphorylation site [posttranslational modification]
438753002935	intermolecular recognition site; other site
438753002936	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
438753002937	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
438753002938	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
438753002939	active site clefts [active]
438753002940	zinc binding site [ion binding]; other site
438753002941	dimer interface [polypeptide binding]; other site
438753002942	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
438753002943	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
438753002944	Walker A/P-loop; other site
438753002945	ATP binding site [chemical binding]; other site
438753002946	Q-loop/lid; other site
438753002947	ABC transporter signature motif; other site
438753002948	Walker B; other site
438753002949	D-loop; other site
438753002950	H-loop/switch region; other site
438753002951	TOBE-like domain; Region: TOBE_3; pfam12857
438753002952	sulfate transport protein; Provisional; Region: cysT; CHL00187
438753002953	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753002954	dimer interface [polypeptide binding]; other site
438753002955	conserved gate region; other site
438753002956	putative PBP binding loops; other site
438753002957	ABC-ATPase subunit interface; other site
438753002958	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
438753002959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753002960	dimer interface [polypeptide binding]; other site
438753002961	conserved gate region; other site
438753002962	putative PBP binding loops; other site
438753002963	ABC-ATPase subunit interface; other site
438753002964	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
438753002965	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753002966	membrane-bound complex binding site; other site
438753002967	hinge residues; other site
438753002968	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
438753002969	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
438753002970	Active Sites [active]
438753002971	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
438753002972	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
438753002973	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
438753002974	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
438753002975	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
438753002976	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
438753002977	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
438753002978	Active Sites [active]
438753002979	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
438753002980	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
438753002981	CysD dimerization site [polypeptide binding]; other site
438753002982	G1 box; other site
438753002983	putative GEF interaction site [polypeptide binding]; other site
438753002984	GTP/Mg2+ binding site [chemical binding]; other site
438753002985	Switch I region; other site
438753002986	G2 box; other site
438753002987	G3 box; other site
438753002988	Switch II region; other site
438753002989	G4 box; other site
438753002990	G5 box; other site
438753002991	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
438753002992	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
438753002993	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
438753002994	ligand-binding site [chemical binding]; other site
438753002995	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
438753002996	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
438753002997	NADP binding site [chemical binding]; other site
438753002998	dimer interface [polypeptide binding]; other site
438753002999	leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011
438753003000	Winged helix-turn helix; Region: HTH_29; pfam13551
438753003001	Integrase core domain; Region: rve; pfam00665
438753003002	Integrase core domain; Region: rve_3; pfam13683
438753003003	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
438753003004	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
438753003005	FMN binding site [chemical binding]; other site
438753003006	substrate binding site [chemical binding]; other site
438753003007	putative catalytic residue [active]
438753003008	enoyl-CoA hydratase; Provisional; Region: PRK06688
438753003009	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
438753003010	substrate binding site [chemical binding]; other site
438753003011	oxyanion hole (OAH) forming residues; other site
438753003012	trimer interface [polypeptide binding]; other site
438753003013	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753003014	NAD(P) binding site [chemical binding]; other site
438753003015	active site
438753003016	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
438753003017	malonic semialdehyde reductase; Provisional; Region: PRK10538
438753003018	putative NAD(P) binding site [chemical binding]; other site
438753003019	homodimer interface [polypeptide binding]; other site
438753003020	homotetramer interface [polypeptide binding]; other site
438753003021	active site
438753003022	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
438753003023	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
438753003024	Domain of unknown function DUF20; Region: UPF0118; pfam01594
438753003025	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
438753003026	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
438753003027	Walker A motif; other site
438753003028	ATP binding site [chemical binding]; other site
438753003029	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
438753003030	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
438753003031	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
438753003032	GTP cyclohydrolase I; Provisional; Region: PLN03044
438753003033	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
438753003034	active site
438753003035	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
438753003036	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
438753003037	trimerization site [polypeptide binding]; other site
438753003038	active site
438753003039	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
438753003040	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
438753003041	active site
438753003042	hypothetical protein; Validated; Region: PRK00041
438753003043	Secretory lipase; Region: LIP; pfam03583
438753003044	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
438753003045	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
438753003046	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
438753003047	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
438753003048	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
438753003049	active site
438753003050	dimer interface [polypeptide binding]; other site
438753003051	motif 1; other site
438753003052	motif 2; other site
438753003053	motif 3; other site
438753003054	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
438753003055	anticodon binding site; other site
438753003056	Autotransporter beta-domain; Region: Autotransporter; smart00869
438753003057	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
438753003058	putative FMN binding site [chemical binding]; other site
438753003059	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
438753003060	ATP-NAD kinase; Region: NAD_kinase; pfam01513
438753003061	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
438753003062	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
438753003063	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
438753003064	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
438753003065	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753003066	substrate binding pocket [chemical binding]; other site
438753003067	membrane-bound complex binding site; other site
438753003068	hinge residues; other site
438753003069	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
438753003070	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
438753003071	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
438753003072	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753003073	Coenzyme A binding pocket [chemical binding]; other site
438753003074	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
438753003075	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
438753003076	Cytochrome c; Region: Cytochrom_C; cl11414
438753003077	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753003078	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
438753003079	active site
438753003080	dimer interface [polypeptide binding]; other site
438753003081	metal binding site [ion binding]; metal-binding site
438753003082	glutathione binding site [chemical binding]; other site
438753003083	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
438753003084	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
438753003085	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
438753003086	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
438753003087	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753003088	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
438753003089	putative effector binding pocket; other site
438753003090	dimerization interface [polypeptide binding]; other site
438753003091	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
438753003092	Predicted membrane protein [Function unknown]; Region: COG4803
438753003093	Chromate transporter; Region: Chromate_transp; pfam02417
438753003094	Chromate transporter; Region: Chromate_transp; pfam02417
438753003095	Response regulator receiver domain; Region: Response_reg; pfam00072
438753003096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753003097	active site
438753003098	phosphorylation site [posttranslational modification]
438753003099	intermolecular recognition site; other site
438753003100	dimerization interface [polypeptide binding]; other site
438753003101	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
438753003102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753003103	active site
438753003104	phosphorylation site [posttranslational modification]
438753003105	intermolecular recognition site; other site
438753003106	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
438753003107	Beta-lactamase; Region: Beta-lactamase; pfam00144
438753003108	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
438753003109	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
438753003110	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
438753003111	active site
438753003112	substrate binding site [chemical binding]; other site
438753003113	metal binding site [ion binding]; metal-binding site
438753003114	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
438753003115	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
438753003116	substrate binding site [chemical binding]; other site
438753003117	ATP binding site [chemical binding]; other site
438753003118	AAA domain; Region: AAA_30; pfam13604
438753003119	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753003120	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753003121	substrate binding pocket [chemical binding]; other site
438753003122	membrane-bound complex binding site; other site
438753003123	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
438753003124	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
438753003125	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
438753003126	active site
438753003127	catalytic triad [active]
438753003128	calcium binding site [ion binding]; other site
438753003129	PRC-barrel domain; Region: PRC; pfam05239
438753003130	arginine:agmatin antiporter; Provisional; Region: PRK10644
438753003131	arginine decarboxylase; Provisional; Region: PRK15029
438753003132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753003133	active site
438753003134	phosphorylation site [posttranslational modification]
438753003135	intermolecular recognition site; other site
438753003136	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
438753003137	homodimer interface [polypeptide binding]; other site
438753003138	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753003139	catalytic residue [active]
438753003140	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
438753003141	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
438753003142	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
438753003143	catalytic residue [active]
438753003144	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
438753003145	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
438753003146	ligand binding site [chemical binding]; other site
438753003147	NAD binding site [chemical binding]; other site
438753003148	dimerization interface [polypeptide binding]; other site
438753003149	catalytic site [active]
438753003150	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
438753003151	putative L-serine binding site [chemical binding]; other site
438753003152	Tetratricopeptide repeat; Region: TPR_12; pfam13424
438753003153	CHAT domain; Region: CHAT; pfam12770
438753003154	EamA-like transporter family; Region: EamA; pfam00892
438753003155	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
438753003156	EamA-like transporter family; Region: EamA; pfam00892
438753003157	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
438753003158	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
438753003159	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
438753003160	Beta-lactamase; Region: Beta-lactamase; pfam00144
438753003161	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
438753003162	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
438753003163	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
438753003164	B12 binding site [chemical binding]; other site
438753003165	cobalt ligand [ion binding]; other site
438753003166	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
438753003167	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
438753003168	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753003169	Coenzyme A transferase; Region: CoA_trans; cl17247
438753003170	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
438753003171	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
438753003172	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
438753003173	dimer interface [polypeptide binding]; other site
438753003174	active site
438753003175	crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246
438753003176	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
438753003177	putative NAD(P) binding site [chemical binding]; other site
438753003178	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753003179	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753003180	metal binding site [ion binding]; metal-binding site
438753003181	active site
438753003182	I-site; other site
438753003183	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
438753003184	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
438753003185	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
438753003186	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
438753003187	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
438753003188	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
438753003189	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
438753003190	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
438753003191	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
438753003192	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
438753003193	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
438753003194	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
438753003195	Walker A/P-loop; other site
438753003196	ATP binding site [chemical binding]; other site
438753003197	Q-loop/lid; other site
438753003198	ABC transporter signature motif; other site
438753003199	Walker B; other site
438753003200	D-loop; other site
438753003201	H-loop/switch region; other site
438753003202	V-type ATP synthase subunit I; Validated; Region: PRK05771
438753003203	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
438753003204	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
438753003205	DNA binding site [nucleotide binding]
438753003206	heterodimer interface [polypeptide binding]; other site
438753003207	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
438753003208	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
438753003209	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
438753003210	active site
438753003211	DNA binding site [nucleotide binding]
438753003212	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
438753003213	DNA binding site [nucleotide binding]
438753003214	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
438753003215	nucleotide binding site [chemical binding]; other site
438753003216	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
438753003217	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
438753003218	putative DNA binding site [nucleotide binding]; other site
438753003219	putative homodimer interface [polypeptide binding]; other site
438753003220	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
438753003221	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
438753003222	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
438753003223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753003224	Mg2+ binding site [ion binding]; other site
438753003225	G-X-G motif; other site
438753003226	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
438753003227	anchoring element; other site
438753003228	dimer interface [polypeptide binding]; other site
438753003229	ATP binding site [chemical binding]; other site
438753003230	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
438753003231	active site
438753003232	putative metal-binding site [ion binding]; other site
438753003233	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
438753003234	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
438753003235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
438753003236	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
438753003237	recombination protein F; Reviewed; Region: recF; PRK00064
438753003238	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753003239	Walker A/P-loop; other site
438753003240	ATP binding site [chemical binding]; other site
438753003241	Q-loop/lid; other site
438753003242	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753003243	ABC transporter signature motif; other site
438753003244	Walker B; other site
438753003245	D-loop; other site
438753003246	H-loop/switch region; other site
438753003247	DNA polymerase III subunit beta; Validated; Region: PRK05643
438753003248	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
438753003249	putative DNA binding surface [nucleotide binding]; other site
438753003250	dimer interface [polypeptide binding]; other site
438753003251	beta-clamp/clamp loader binding surface; other site
438753003252	beta-clamp/translesion DNA polymerase binding surface; other site
438753003253	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
438753003254	DnaA N-terminal domain; Region: DnaA_N; pfam11638
438753003255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753003256	Walker A motif; other site
438753003257	ATP binding site [chemical binding]; other site
438753003258	Walker B motif; other site
438753003259	arginine finger; other site
438753003260	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
438753003261	DnaA box-binding interface [nucleotide binding]; other site
438753003262	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
438753003263	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
438753003264	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
438753003265	putative NAD(P) binding site [chemical binding]; other site
438753003266	active site
438753003267	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
438753003268	active site
438753003269	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
438753003270	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
438753003271	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753003272	catalytic residue [active]
438753003273	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
438753003274	substrate binding site [chemical binding]; other site
438753003275	active site
438753003276	catalytic residues [active]
438753003277	heterodimer interface [polypeptide binding]; other site
438753003278	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
438753003279	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
438753003280	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
438753003281	Na binding site [ion binding]; other site
438753003282	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
438753003283	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
438753003284	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
438753003285	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
438753003286	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753003287	PAS domain; Region: PAS_9; pfam13426
438753003288	putative active site [active]
438753003289	heme pocket [chemical binding]; other site
438753003290	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753003291	PAS domain; Region: PAS_9; pfam13426
438753003292	putative active site [active]
438753003293	heme pocket [chemical binding]; other site
438753003294	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753003295	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753003296	dimer interface [polypeptide binding]; other site
438753003297	putative CheW interface [polypeptide binding]; other site
438753003298	EamA-like transporter family; Region: EamA; pfam00892
438753003299	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
438753003300	dimer interface [polypeptide binding]; other site
438753003301	motif 1; other site
438753003302	active site
438753003303	motif 2; other site
438753003304	motif 3; other site
438753003305	metabolite-proton symporter; Region: 2A0106; TIGR00883
438753003306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753003307	putative substrate translocation pore; other site
438753003308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753003309	metabolite-proton symporter; Region: 2A0106; TIGR00883
438753003310	putative substrate translocation pore; other site
438753003311	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
438753003312	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
438753003313	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
438753003314	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
438753003315	4Fe-4S binding domain; Region: Fer4; cl02805
438753003316	probable nitrogen fixation protein; Region: TIGR02935
438753003317	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
438753003318	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
438753003319	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
438753003320	nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478
438753003321	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
438753003322	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
438753003323	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
438753003324	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
438753003325	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
438753003326	MoFe protein beta/alpha subunit interactions; other site
438753003327	Beta subunit P cluster binding residues; other site
438753003328	MoFe protein beta subunit/Fe protein contacts; other site
438753003329	MoFe protein dimer/ dimer interactions; other site
438753003330	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
438753003331	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
438753003332	MoFe protein alpha/beta subunit interactions; other site
438753003333	Alpha subunit P cluster binding residues; other site
438753003334	FeMoco binding residues [chemical binding]; other site
438753003335	MoFe protein alpha subunit/Fe protein contacts; other site
438753003336	MoFe protein dimer/ dimer interactions; other site
438753003337	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
438753003338	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
438753003339	Nucleotide-binding sites [chemical binding]; other site
438753003340	Walker A motif; other site
438753003341	Switch I region of nucleotide binding site; other site
438753003342	Fe4S4 binding sites [ion binding]; other site
438753003343	Switch II region of nucleotide binding site; other site
438753003344	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
438753003345	hypothetical protein; Provisional; Region: PRK13795
438753003346	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
438753003347	putative ABC transporter; Region: ycf24; CHL00085
438753003348	FeS assembly ATPase SufC; Region: sufC; TIGR01978
438753003349	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
438753003350	Walker A/P-loop; other site
438753003351	ATP binding site [chemical binding]; other site
438753003352	Q-loop/lid; other site
438753003353	ABC transporter signature motif; other site
438753003354	Walker B; other site
438753003355	D-loop; other site
438753003356	H-loop/switch region; other site
438753003357	FeS assembly protein SufD; Region: sufD; TIGR01981
438753003358	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
438753003359	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
438753003360	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
438753003361	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
438753003362	catalytic residue [active]
438753003363	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
438753003364	Nif-specific regulatory protein; Region: nifA; TIGR01817
438753003365	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
438753003366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753003367	Walker A motif; other site
438753003368	ATP binding site [chemical binding]; other site
438753003369	Walker B motif; other site
438753003370	arginine finger; other site
438753003371	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
438753003372	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
438753003373	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
438753003374	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
438753003375	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
438753003376	dimer interface [polypeptide binding]; other site
438753003377	decamer (pentamer of dimers) interface [polypeptide binding]; other site
438753003378	catalytic triad [active]
438753003379	peroxidatic and resolving cysteines [active]
438753003380	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
438753003381	molybdenum transport protein ModD; Provisional; Region: PRK06096
438753003382	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
438753003383	active site
438753003384	molybdenum-pterin binding domain; Region: Mop; TIGR00638
438753003385	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
438753003386	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
438753003387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753003388	dimer interface [polypeptide binding]; other site
438753003389	conserved gate region; other site
438753003390	ABC-ATPase subunit interface; other site
438753003391	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
438753003392	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753003393	membrane-bound complex binding site; other site
438753003394	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
438753003395	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
438753003396	Walker A/P-loop; other site
438753003397	ATP binding site [chemical binding]; other site
438753003398	Q-loop/lid; other site
438753003399	ABC transporter signature motif; other site
438753003400	Walker B; other site
438753003401	D-loop; other site
438753003402	H-loop/switch region; other site
438753003403	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753003404	Amidase; Region: Amidase; cl11426
438753003405	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
438753003406	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
438753003407	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753003408	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753003409	WHG domain; Region: WHG; pfam13305
438753003410	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
438753003411	classical (c) SDRs; Region: SDR_c; cd05233
438753003412	NAD(P) binding site [chemical binding]; other site
438753003413	active site
438753003414	pyridoxamine kinase; Validated; Region: PRK05756
438753003415	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
438753003416	dimer interface [polypeptide binding]; other site
438753003417	pyridoxal binding site [chemical binding]; other site
438753003418	ATP binding site [chemical binding]; other site
438753003419	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
438753003420	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
438753003421	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
438753003422	FMN binding site [chemical binding]; other site
438753003423	active site
438753003424	substrate binding site [chemical binding]; other site
438753003425	catalytic residue [active]
438753003426	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
438753003427	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
438753003428	Predicted flavoprotein [General function prediction only]; Region: COG0431
438753003429	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
438753003430	active site
438753003431	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
438753003432	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753003433	FeS/SAM binding site; other site
438753003434	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
438753003435	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753003436	Zn binding site [ion binding]; other site
438753003437	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
438753003438	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753003439	Zn binding site [ion binding]; other site
438753003440	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
438753003441	MarR family; Region: MarR; pfam01047
438753003442	Fusaric acid resistance protein family; Region: FUSC; pfam04632
438753003443	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
438753003444	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
438753003445	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753003446	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753003447	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753003448	dimerization interface [polypeptide binding]; other site
438753003449	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753003450	dimer interface [polypeptide binding]; other site
438753003451	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753003452	putative CheW interface [polypeptide binding]; other site
438753003453	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753003454	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753003455	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
438753003456	dimerization interface [polypeptide binding]; other site
438753003457	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
438753003458	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
438753003459	active site
438753003460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
438753003461	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
438753003462	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
438753003463	methionine sulfoxide reductase B; Provisional; Region: PRK00222
438753003464	SelR domain; Region: SelR; pfam01641
438753003465	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
438753003466	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
438753003467	DnaA box-binding interface [nucleotide binding]; other site
438753003468	Protein of unknown function (DUF805); Region: DUF805; pfam05656
438753003469	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
438753003470	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753003471	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753003472	dimer interface [polypeptide binding]; other site
438753003473	phosphorylation site [posttranslational modification]
438753003474	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753003475	ATP binding site [chemical binding]; other site
438753003476	Mg2+ binding site [ion binding]; other site
438753003477	G-X-G motif; other site
438753003478	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
438753003479	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
438753003480	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
438753003481	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
438753003482	Predicted dehydrogenase [General function prediction only]; Region: COG0579
438753003483	hydroxyglutarate oxidase; Provisional; Region: PRK11728
438753003484	Predicted integral membrane protein [Function unknown]; Region: COG5436
438753003485	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
438753003486	Transglycosylase; Region: Transgly; pfam00912
438753003487	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
438753003488	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
438753003489	hypothetical protein; Provisional; Region: PRK05170
438753003490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753003491	putative transporter; Provisional; Region: PRK10504
438753003492	putative substrate translocation pore; other site
438753003493	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753003494	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
438753003495	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
438753003496	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
438753003497	Uncharacterized conserved protein [Function unknown]; Region: COG5323
438753003498	Terminase-like family; Region: Terminase_6; pfam03237
438753003499	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
438753003500	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753003501	active site
438753003502	benzoate transport; Region: 2A0115; TIGR00895
438753003503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753003504	putative substrate translocation pore; other site
438753003505	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
438753003506	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753003507	DNA-binding site [nucleotide binding]; DNA binding site
438753003508	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
438753003509	Phage-related protein [Function unknown]; Region: COG4695
438753003510	Phage portal protein; Region: Phage_portal; pfam04860
438753003511	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
438753003512	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
438753003513	Phage capsid family; Region: Phage_capsid; pfam05065
438753003514	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
438753003515	cleavage site
438753003516	active site
438753003517	substrate binding sites [chemical binding]; other site
438753003518	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
438753003519	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
438753003520	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
438753003521	oligomerization interface [polypeptide binding]; other site
438753003522	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
438753003523	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
438753003524	Phage major tail protein 2; Region: Phage_tail_2; cl11463
438753003525	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
438753003526	Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550
438753003527	Phage-related minor tail protein [Function unknown]; Region: COG5281
438753003528	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
438753003529	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
438753003530	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
438753003531	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
438753003532	NlpC/P60 family; Region: NLPC_P60; cl17555
438753003533	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
438753003534	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
438753003535	Putative phage tail protein; Region: Phage-tail_3; pfam13550
438753003536	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
438753003537	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753003538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753003539	active site
438753003540	phosphorylation site [posttranslational modification]
438753003541	intermolecular recognition site; other site
438753003542	dimerization interface [polypeptide binding]; other site
438753003543	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753003544	DNA binding site [nucleotide binding]
438753003545	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753003546	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
438753003547	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753003548	ATP binding site [chemical binding]; other site
438753003549	Mg2+ binding site [ion binding]; other site
438753003550	G-X-G motif; other site
438753003551	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
438753003552	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
438753003553	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
438753003554	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
438753003555	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
438753003556	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
438753003557	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
438753003558	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
438753003559	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
438753003560	protein binding site [polypeptide binding]; other site
438753003561	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
438753003562	protein binding site [polypeptide binding]; other site
438753003563	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753003564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753003565	active site
438753003566	phosphorylation site [posttranslational modification]
438753003567	intermolecular recognition site; other site
438753003568	dimerization interface [polypeptide binding]; other site
438753003569	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753003570	DNA binding site [nucleotide binding]
438753003571	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
438753003572	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
438753003573	metal binding triad; other site
438753003574	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
438753003575	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
438753003576	metal binding triad; other site
438753003577	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
438753003578	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
438753003579	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
438753003580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753003581	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
438753003582	putative substrate translocation pore; other site
438753003583	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753003584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753003585	S-adenosylmethionine binding site [chemical binding]; other site
438753003586	Predicted membrane protein [Function unknown]; Region: COG2246
438753003587	GtrA-like protein; Region: GtrA; pfam04138
438753003588	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
438753003589	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
438753003590	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
438753003591	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
438753003592	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
438753003593	ATP-grasp domain; Region: ATP-grasp_4; cl17255
438753003594	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
438753003595	IMP binding site; other site
438753003596	dimer interface [polypeptide binding]; other site
438753003597	interdomain contacts; other site
438753003598	partial ornithine binding site; other site
438753003599	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
438753003600	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
438753003601	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
438753003602	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
438753003603	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753003604	putative DNA binding site [nucleotide binding]; other site
438753003605	putative Zn2+ binding site [ion binding]; other site
438753003606	AsnC family; Region: AsnC_trans_reg; pfam01037
438753003607	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
438753003608	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
438753003609	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
438753003610	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753003611	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753003612	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
438753003613	putative effector binding pocket; other site
438753003614	dimerization interface [polypeptide binding]; other site
438753003615	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
438753003616	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
438753003617	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
438753003618	G1 box; other site
438753003619	putative GEF interaction site [polypeptide binding]; other site
438753003620	GTP/Mg2+ binding site [chemical binding]; other site
438753003621	Switch I region; other site
438753003622	G2 box; other site
438753003623	G3 box; other site
438753003624	Switch II region; other site
438753003625	G4 box; other site
438753003626	G5 box; other site
438753003627	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
438753003628	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
438753003629	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
438753003630	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
438753003631	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
438753003632	Sel1-like repeats; Region: SEL1; smart00671
438753003633	Sel1-like repeats; Region: SEL1; smart00671
438753003634	selenocysteine synthase; Provisional; Region: PRK04311
438753003635	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
438753003636	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
438753003637	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
438753003638	catalytic residue [active]
438753003639	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
438753003640	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
438753003641	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
438753003642	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
438753003643	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
438753003644	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
438753003645	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
438753003646	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
438753003647	molybdopterin cofactor binding site; other site
438753003648	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
438753003649	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
438753003650	molybdopterin cofactor binding site; other site
438753003651	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
438753003652	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
438753003653	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
438753003654	catalytic residues [active]
438753003655	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
438753003656	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
438753003657	selenophosphate synthetase; Provisional; Region: PRK00943
438753003658	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
438753003659	dimerization interface [polypeptide binding]; other site
438753003660	putative ATP binding site [chemical binding]; other site
438753003661	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
438753003662	AAA domain; Region: AAA_33; pfam13671
438753003663	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753003664	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753003665	dimer interface [polypeptide binding]; other site
438753003666	phosphorylation site [posttranslational modification]
438753003667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753003668	ATP binding site [chemical binding]; other site
438753003669	Mg2+ binding site [ion binding]; other site
438753003670	G-X-G motif; other site
438753003671	Response regulator receiver domain; Region: Response_reg; pfam00072
438753003672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753003673	active site
438753003674	phosphorylation site [posttranslational modification]
438753003675	intermolecular recognition site; other site
438753003676	dimerization interface [polypeptide binding]; other site
438753003677	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
438753003678	putative deacylase active site [active]
438753003679	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
438753003680	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
438753003681	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
438753003682	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
438753003683	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
438753003684	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
438753003685	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
438753003686	hydroxyglutarate oxidase; Provisional; Region: PRK11728
438753003687	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
438753003688	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
438753003689	[2Fe-2S] cluster binding site [ion binding]; other site
438753003690	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
438753003691	putative alpha subunit interface [polypeptide binding]; other site
438753003692	putative active site [active]
438753003693	putative substrate binding site [chemical binding]; other site
438753003694	Fe binding site [ion binding]; other site
438753003695	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
438753003696	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
438753003697	FAD binding pocket [chemical binding]; other site
438753003698	FAD binding motif [chemical binding]; other site
438753003699	phosphate binding motif [ion binding]; other site
438753003700	beta-alpha-beta structure motif; other site
438753003701	NAD binding pocket [chemical binding]; other site
438753003702	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753003703	catalytic loop [active]
438753003704	iron binding site [ion binding]; other site
438753003705	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
438753003706	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
438753003707	conserved cys residue [active]
438753003708	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753003709	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753003710	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
438753003711	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
438753003712	putative active site [active]
438753003713	putative FMN binding site [chemical binding]; other site
438753003714	putative substrate binding site [chemical binding]; other site
438753003715	putative catalytic residue [active]
438753003716	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
438753003717	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
438753003718	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
438753003719	Cysteine-rich domain; Region: CCG; pfam02754
438753003720	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
438753003721	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
438753003722	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753003723	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753003724	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
438753003725	putative dimerization interface [polypeptide binding]; other site
438753003726	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-1; cd12808
438753003727	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
438753003728	catalytic site [active]
438753003729	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
438753003730	Citrate transporter; Region: CitMHS; pfam03600
438753003731	choline dehydrogenase; Validated; Region: PRK02106
438753003732	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
438753003733	transcriptional regulator BetI; Validated; Region: PRK00767
438753003734	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753003735	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
438753003736	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
438753003737	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
438753003738	NAD(P) binding site [chemical binding]; other site
438753003739	catalytic residues [active]
438753003740	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
438753003741	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
438753003742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753003743	dimer interface [polypeptide binding]; other site
438753003744	conserved gate region; other site
438753003745	putative PBP binding loops; other site
438753003746	ABC-ATPase subunit interface; other site
438753003747	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
438753003748	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753003749	Walker A/P-loop; other site
438753003750	ATP binding site [chemical binding]; other site
438753003751	Q-loop/lid; other site
438753003752	ABC transporter signature motif; other site
438753003753	Walker B; other site
438753003754	D-loop; other site
438753003755	H-loop/switch region; other site
438753003756	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
438753003757	CoA-transferase family III; Region: CoA_transf_3; pfam02515
438753003758	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
438753003759	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
438753003760	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753003761	putative DNA binding site [nucleotide binding]; other site
438753003762	putative Zn2+ binding site [ion binding]; other site
438753003763	AsnC family; Region: AsnC_trans_reg; pfam01037
438753003764	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
438753003765	EamA-like transporter family; Region: EamA; pfam00892
438753003766	EamA-like transporter family; Region: EamA; pfam00892
438753003767	threonine dehydratase; Reviewed; Region: PRK09224
438753003768	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
438753003769	tetramer interface [polypeptide binding]; other site
438753003770	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753003771	catalytic residue [active]
438753003772	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
438753003773	putative Ile/Val binding site [chemical binding]; other site
438753003774	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
438753003775	putative Ile/Val binding site [chemical binding]; other site
438753003776	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
438753003777	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
438753003778	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
438753003779	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
438753003780	Cl binding site [ion binding]; other site
438753003781	oligomer interface [polypeptide binding]; other site
438753003782	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
438753003783	classical (c) SDRs; Region: SDR_c; cd05233
438753003784	NAD(P) binding site [chemical binding]; other site
438753003785	active site
438753003786	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
438753003787	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
438753003788	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
438753003789	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
438753003790	HSP70 interaction site [polypeptide binding]; other site
438753003791	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
438753003792	substrate binding site [polypeptide binding]; other site
438753003793	dimer interface [polypeptide binding]; other site
438753003794	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753003795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753003796	active site
438753003797	phosphorylation site [posttranslational modification]
438753003798	intermolecular recognition site; other site
438753003799	dimerization interface [polypeptide binding]; other site
438753003800	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753003801	DNA binding site [nucleotide binding]
438753003802	RNA polymerase sigma factor; Provisional; Region: PRK12514
438753003803	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
438753003804	Anti-sigma-K factor rskA; Region: RskA; pfam10099
438753003805	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753003806	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753003807	metal binding site [ion binding]; metal-binding site
438753003808	active site
438753003809	I-site; other site
438753003810	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
438753003811	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
438753003812	Walker A/P-loop; other site
438753003813	ATP binding site [chemical binding]; other site
438753003814	Q-loop/lid; other site
438753003815	ABC transporter signature motif; other site
438753003816	Walker B; other site
438753003817	D-loop; other site
438753003818	H-loop/switch region; other site
438753003819	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
438753003820	agmatinase; Region: agmatinase; TIGR01230
438753003821	oligomer interface [polypeptide binding]; other site
438753003822	putative active site [active]
438753003823	Mn binding site [ion binding]; other site
438753003824	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
438753003825	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
438753003826	NADH dehydrogenase; Validated; Region: PRK08183
438753003827	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
438753003828	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753003829	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753003830	metal binding site [ion binding]; metal-binding site
438753003831	active site
438753003832	I-site; other site
438753003833	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753003834	AAA domain; Region: AAA_23; pfam13476
438753003835	Walker A/P-loop; other site
438753003836	ATP binding site [chemical binding]; other site
438753003837	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
438753003838	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
438753003839	active site
438753003840	metal binding site [ion binding]; metal-binding site
438753003841	DNA binding site [nucleotide binding]
438753003842	Porin subfamily; Region: Porin_2; pfam02530
438753003843	Uncharacterized conserved protein [Function unknown]; Region: COG3743
438753003844	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
438753003845	catalytic center binding site [active]
438753003846	ATP binding site [chemical binding]; other site
438753003847	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
438753003848	dihydropteroate synthase; Region: DHPS; TIGR01496
438753003849	substrate binding pocket [chemical binding]; other site
438753003850	dimer interface [polypeptide binding]; other site
438753003851	inhibitor binding site; inhibition site
438753003852	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
438753003853	Uncharacterized conserved protein [Function unknown]; Region: COG2938
438753003854	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
438753003855	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
438753003856	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
438753003857	ATP binding site [chemical binding]; other site
438753003858	putative Mg++ binding site [ion binding]; other site
438753003859	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
438753003860	nucleotide binding region [chemical binding]; other site
438753003861	ATP-binding site [chemical binding]; other site
438753003862	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
438753003863	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753003864	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
438753003865	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
438753003866	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
438753003867	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
438753003868	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753003869	dimerization interface [polypeptide binding]; other site
438753003870	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753003871	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753003872	dimer interface [polypeptide binding]; other site
438753003873	putative CheW interface [polypeptide binding]; other site
438753003874	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
438753003875	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
438753003876	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
438753003877	putative active site pocket [active]
438753003878	dimerization interface [polypeptide binding]; other site
438753003879	putative catalytic residue [active]
438753003880	Predicted permeases [General function prediction only]; Region: COG0679
438753003881	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
438753003882	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753003883	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
438753003884	putative dimerization interface [polypeptide binding]; other site
438753003885	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
438753003886	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
438753003887	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
438753003888	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753003889	Walker A/P-loop; other site
438753003890	ATP binding site [chemical binding]; other site
438753003891	Q-loop/lid; other site
438753003892	ABC transporter signature motif; other site
438753003893	Walker B; other site
438753003894	D-loop; other site
438753003895	H-loop/switch region; other site
438753003896	TOBE domain; Region: TOBE_2; pfam08402
438753003897	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
438753003898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753003899	dimer interface [polypeptide binding]; other site
438753003900	conserved gate region; other site
438753003901	putative PBP binding loops; other site
438753003902	ABC-ATPase subunit interface; other site
438753003903	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
438753003904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753003905	dimer interface [polypeptide binding]; other site
438753003906	conserved gate region; other site
438753003907	putative PBP binding loops; other site
438753003908	ABC-ATPase subunit interface; other site
438753003909	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
438753003910	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
438753003911	hydroxyglutarate oxidase; Provisional; Region: PRK11728
438753003912	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
438753003913	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
438753003914	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
438753003915	hydroxyglutarate oxidase; Provisional; Region: PRK11728
438753003916	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
438753003917	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
438753003918	dimer interface [polypeptide binding]; other site
438753003919	active site
438753003920	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
438753003921	substrate binding site [chemical binding]; other site
438753003922	catalytic residue [active]
438753003923	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
438753003924	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
438753003925	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
438753003926	putative C-terminal domain interface [polypeptide binding]; other site
438753003927	putative GSH binding site (G-site) [chemical binding]; other site
438753003928	putative dimer interface [polypeptide binding]; other site
438753003929	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
438753003930	N-terminal domain interface [polypeptide binding]; other site
438753003931	dimer interface [polypeptide binding]; other site
438753003932	substrate binding pocket (H-site) [chemical binding]; other site
438753003933	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
438753003934	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
438753003935	N-acetyl-D-glucosamine binding site [chemical binding]; other site
438753003936	catalytic residue [active]
438753003937	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
438753003938	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
438753003939	dimer interface [polypeptide binding]; other site
438753003940	active site
438753003941	catalytic residue [active]
438753003942	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
438753003943	SmpB-tmRNA interface; other site
438753003944	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753003945	Coenzyme A binding pocket [chemical binding]; other site
438753003946	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
438753003947	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
438753003948	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
438753003949	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
438753003950	catalytic triad [active]
438753003951	Cytochrome c; Region: Cytochrom_C; cl11414
438753003952	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
438753003953	Fe-S cluster binding site [ion binding]; other site
438753003954	DNA binding site [nucleotide binding]
438753003955	active site
438753003956	Uncharacterized conserved protein [Function unknown]; Region: COG1432
438753003957	LabA_like proteins; Region: LabA; cd10911
438753003958	putative metal binding site [ion binding]; other site
438753003959	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
438753003960	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
438753003961	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
438753003962	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753003963	FeS/SAM binding site; other site
438753003964	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
438753003965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753003966	putative substrate translocation pore; other site
438753003967	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753003968	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
438753003969	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
438753003970	N-terminal plug; other site
438753003971	ligand-binding site [chemical binding]; other site
438753003972	tonB-system energizer ExbB; Region: exbB; TIGR02797
438753003973	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
438753003974	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
438753003975	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
438753003976	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
438753003977	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
438753003978	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
438753003979	dimer interface [polypeptide binding]; other site
438753003980	active site
438753003981	glycine-pyridoxal phosphate binding site [chemical binding]; other site
438753003982	folate binding site [chemical binding]; other site
438753003983	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
438753003984	ATP cone domain; Region: ATP-cone; pfam03477
438753003985	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
438753003986	catalytic motif [active]
438753003987	Zn binding site [ion binding]; other site
438753003988	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
438753003989	RibD C-terminal domain; Region: RibD_C; cl17279
438753003990	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
438753003991	Lumazine binding domain; Region: Lum_binding; pfam00677
438753003992	Lumazine binding domain; Region: Lum_binding; pfam00677
438753003993	6,7-dimethyl-8-ribityllumazine synthase; Provisional; Region: ribH; PRK00061
438753003994	active site
438753003995	homopentamer interface [polypeptide binding]; other site
438753003996	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
438753003997	thiamine monophosphate kinase; Provisional; Region: PRK05731
438753003998	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
438753003999	ATP binding site [chemical binding]; other site
438753004000	dimerization interface [polypeptide binding]; other site
438753004001	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
438753004002	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
438753004003	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
438753004004	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
438753004005	active site
438753004006	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
438753004007	TSCPD domain; Region: TSCPD; pfam12637
438753004008	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753004009	putative DNA binding site [nucleotide binding]; other site
438753004010	putative Zn2+ binding site [ion binding]; other site
438753004011	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
438753004012	Low molecular weight phosphatase family; Region: LMWPc; cd00115
438753004013	active site
438753004014	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
438753004015	ArsC family; Region: ArsC; pfam03960
438753004016	catalytic residues [active]
438753004017	arsenical pump membrane protein; Provisional; Region: PRK15445
438753004018	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
438753004019	transmembrane helices; other site
438753004020	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
438753004021	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
438753004022	Predicted transcriptional regulators [Transcription]; Region: COG1695
438753004023	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
438753004024	short chain dehydrogenase; Provisional; Region: PRK06179
438753004025	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
438753004026	NADP binding site [chemical binding]; other site
438753004027	active site
438753004028	steroid binding site; other site
438753004029	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
438753004030	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
438753004031	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753004032	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753004033	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753004034	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753004035	4Fe-4S binding domain; Region: Fer4; pfam00037
438753004036	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
438753004037	SCP-2 sterol transfer family; Region: SCP2; pfam02036
438753004038	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
438753004039	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
438753004040	FAD binding pocket [chemical binding]; other site
438753004041	conserved FAD binding motif [chemical binding]; other site
438753004042	phosphate binding motif [ion binding]; other site
438753004043	beta-alpha-beta structure motif; other site
438753004044	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
438753004045	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753004046	catalytic loop [active]
438753004047	iron binding site [ion binding]; other site
438753004048	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
438753004049	Transposase; Region: HTH_Tnp_1; pfam01527
438753004050	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
438753004051	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
438753004052	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
438753004053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
438753004054	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
438753004055	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
438753004056	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
438753004057	Predicted transcriptional regulators [Transcription]; Region: COG1733
438753004058	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753004059	dimerization interface [polypeptide binding]; other site
438753004060	putative DNA binding site [nucleotide binding]; other site
438753004061	putative Zn2+ binding site [ion binding]; other site
438753004062	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
438753004063	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
438753004064	HTH-like domain; Region: HTH_21; pfam13276
438753004065	Integrase core domain; Region: rve; pfam00665
438753004066	Integrase core domain; Region: rve_3; pfam13683
438753004067	Cupin domain; Region: Cupin_2; pfam07883
438753004068	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
438753004069	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753004070	Protein of unknown function (DUF790); Region: DUF790; pfam05626
438753004071	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753004072	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753004073	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
438753004074	putative effector binding pocket; other site
438753004075	putative dimerization interface [polypeptide binding]; other site
438753004076	SnoaL-like domain; Region: SnoaL_2; pfam12680
438753004077	short chain dehydrogenase; Provisional; Region: PRK06523
438753004078	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753004079	NAD(P) binding site [chemical binding]; other site
438753004080	active site
438753004081	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753004082	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753004083	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
438753004084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753004085	active site
438753004086	phosphorylation site [posttranslational modification]
438753004087	intermolecular recognition site; other site
438753004088	dimerization interface [polypeptide binding]; other site
438753004089	LytTr DNA-binding domain; Region: LytTR; pfam04397
438753004090	Histidine kinase; Region: His_kinase; pfam06580
438753004091	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
438753004092	ATP binding site [chemical binding]; other site
438753004093	Mg2+ binding site [ion binding]; other site
438753004094	G-X-G motif; other site
438753004095	Calx-beta domain; Region: Calx-beta; pfam03160
438753004096	Calx-beta domain; Region: Calx-beta; cl02522
438753004097	Calx-beta domain; Region: Calx-beta; cl02522
438753004098	Calx-beta domain; Region: Calx-beta; pfam03160
438753004099	Cellulose binding domain; Region: CBM_2; pfam00553
438753004100	Calx-beta domain; Region: Calx-beta; cl02522
438753004101	Calx-beta domain; Region: Calx-beta; cl02522
438753004102	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
438753004103	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
438753004104	Calx-beta domain; Region: Calx-beta; cl02522
438753004105	CBD_II domain; Region: CBD_II; smart00637
438753004106	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
438753004107	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
438753004108	ligand binding site [chemical binding]; other site
438753004109	flexible hinge region; other site
438753004110	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
438753004111	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
438753004112	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
438753004113	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
438753004114	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
438753004115	active site
438753004116	nucleophile elbow; other site
438753004117	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
438753004118	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
438753004119	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
438753004120	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
438753004121	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753004122	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753004123	LysR substrate binding domain; Region: LysR_substrate; pfam03466
438753004124	dimerization interface [polypeptide binding]; other site
438753004125	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
438753004126	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
438753004127	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
438753004128	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
438753004129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
438753004130	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753004131	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753004132	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
438753004133	putative effector binding pocket; other site
438753004134	dimerization interface [polypeptide binding]; other site
438753004135	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
438753004136	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
438753004137	NAD(P) binding site [chemical binding]; other site
438753004138	transcriptional activator RhaR; Provisional; Region: PRK13502
438753004139	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753004140	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
438753004141	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753004142	short chain dehydrogenase; Provisional; Region: PRK12937
438753004143	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
438753004144	NADP binding site [chemical binding]; other site
438753004145	homodimer interface [polypeptide binding]; other site
438753004146	active site
438753004147	substrate binding site [chemical binding]; other site
438753004148	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753004149	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753004150	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
438753004151	putative effector binding pocket; other site
438753004152	dimerization interface [polypeptide binding]; other site
438753004153	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753004154	dimerization interface [polypeptide binding]; other site
438753004155	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753004156	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753004157	dimer interface [polypeptide binding]; other site
438753004158	putative CheW interface [polypeptide binding]; other site
438753004159	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
438753004160	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753004161	active site
438753004162	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
438753004163	classical (c) SDRs; Region: SDR_c; cd05233
438753004164	NAD(P) binding site [chemical binding]; other site
438753004165	active site
438753004166	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
438753004167	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
438753004168	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
438753004169	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
438753004170	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753004171	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753004172	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
438753004173	putative dimerization interface [polypeptide binding]; other site
438753004174	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
438753004175	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
438753004176	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
438753004177	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
438753004178	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753004179	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
438753004180	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
438753004181	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
438753004182	muropeptide transporter; Validated; Region: ampG; cl17669
438753004183	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
438753004184	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
438753004185	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
438753004186	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753004187	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
438753004188	FecR protein; Region: FecR; pfam04773
438753004189	Secretin and TonB N terminus short domain; Region: STN; smart00965
438753004190	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
438753004191	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
438753004192	N-terminal plug; other site
438753004193	ligand-binding site [chemical binding]; other site
438753004194	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
438753004195	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
438753004196	transcriptional regulator; Provisional; Region: PRK10632
438753004197	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753004198	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
438753004199	putative effector binding pocket; other site
438753004200	putative dimerization interface [polypeptide binding]; other site
438753004201	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
438753004202	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
438753004203	Cu(I) binding site [ion binding]; other site
438753004204	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
438753004205	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
438753004206	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
438753004207	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
438753004208	hypothetical protein; Provisional; Region: PRK07236
438753004209	FAD binding domain; Region: FAD_binding_3; pfam01494
438753004210	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
438753004211	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
438753004212	substrate binding site [chemical binding]; other site
438753004213	activation loop (A-loop); other site
438753004214	AAA ATPase domain; Region: AAA_16; pfam13191
438753004215	AAA domain; Region: AAA_22; pfam13401
438753004216	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
438753004217	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
438753004218	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753004219	dimer interface [polypeptide binding]; other site
438753004220	phosphorylation site [posttranslational modification]
438753004221	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753004222	ATP binding site [chemical binding]; other site
438753004223	Mg2+ binding site [ion binding]; other site
438753004224	G-X-G motif; other site
438753004225	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
438753004226	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753004227	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753004228	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
438753004229	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
438753004230	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
438753004231	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
438753004232	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
438753004233	Cupin; Region: Cupin_1; smart00835
438753004234	Cupin; Region: Cupin_1; smart00835
438753004235	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
438753004236	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
438753004237	dimer interface [polypeptide binding]; other site
438753004238	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
438753004239	catalytic triad [active]
438753004240	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
438753004241	Thioredoxin; Region: Thioredoxin_4; cl17273
438753004242	flagellin; Reviewed; Region: PRK12687
438753004243	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
438753004244	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
438753004245	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
438753004246	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
438753004247	pyruvate dehydrogenase; Provisional; Region: PRK09124
438753004248	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
438753004249	PYR/PP interface [polypeptide binding]; other site
438753004250	dimer interface [polypeptide binding]; other site
438753004251	tetramer interface [polypeptide binding]; other site
438753004252	TPP binding site [chemical binding]; other site
438753004253	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
438753004254	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
438753004255	TPP-binding site [chemical binding]; other site
438753004256	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
438753004257	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
438753004258	putative molybdopterin cofactor binding site [chemical binding]; other site
438753004259	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
438753004260	putative molybdopterin cofactor binding site; other site
438753004261	HlyD family secretion protein; Region: HlyD; pfam00529
438753004262	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753004263	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753004264	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
438753004265	Fusaric acid resistance protein family; Region: FUSC; pfam04632
438753004266	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
438753004267	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
438753004268	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753004269	putative active site [active]
438753004270	heme pocket [chemical binding]; other site
438753004271	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753004272	dimer interface [polypeptide binding]; other site
438753004273	phosphorylation site [posttranslational modification]
438753004274	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753004275	ATP binding site [chemical binding]; other site
438753004276	Mg2+ binding site [ion binding]; other site
438753004277	G-X-G motif; other site
438753004278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753004279	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
438753004280	active site
438753004281	phosphorylation site [posttranslational modification]
438753004282	intermolecular recognition site; other site
438753004283	dimerization interface [polypeptide binding]; other site
438753004284	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
438753004285	DNA binding residues [nucleotide binding]
438753004286	dimerization interface [polypeptide binding]; other site
438753004287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753004288	Response regulator receiver domain; Region: Response_reg; pfam00072
438753004289	active site
438753004290	phosphorylation site [posttranslational modification]
438753004291	intermolecular recognition site; other site
438753004292	dimerization interface [polypeptide binding]; other site
438753004293	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
438753004294	Protein export membrane protein; Region: SecD_SecF; cl14618
438753004295	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
438753004296	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753004297	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753004298	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
438753004299	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
438753004300	active site
438753004301	dimer interface [polypeptide binding]; other site
438753004302	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
438753004303	Ligand Binding Site [chemical binding]; other site
438753004304	Molecular Tunnel; other site
438753004305	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
438753004306	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
438753004307	putative active site [active]
438753004308	putative dimer interface [polypeptide binding]; other site
438753004309	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
438753004310	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753004311	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336
438753004312	putative ligand binding site [chemical binding]; other site
438753004313	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753004314	Transcriptional regulators [Transcription]; Region: FadR; COG2186
438753004315	DNA-binding site [nucleotide binding]; DNA binding site
438753004316	FCD domain; Region: FCD; pfam07729
438753004317	Amino acid permease; Region: AA_permease_2; pfam13520
438753004318	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
438753004319	NAD binding pocket [chemical binding]; other site
438753004320	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
438753004321	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
438753004322	FMN-binding pocket [chemical binding]; other site
438753004323	flavin binding motif; other site
438753004324	phosphate binding motif [ion binding]; other site
438753004325	beta-alpha-beta structure motif; other site
438753004326	NAD binding pocket [chemical binding]; other site
438753004327	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753004328	catalytic loop [active]
438753004329	iron binding site [ion binding]; other site
438753004330	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
438753004331	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
438753004332	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
438753004333	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
438753004334	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
438753004335	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
438753004336	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
438753004337	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
438753004338	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
438753004339	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
438753004340	putative active site [active]
438753004341	putative substrate binding site [chemical binding]; other site
438753004342	putative cosubstrate binding site; other site
438753004343	catalytic site [active]
438753004344	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
438753004345	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
438753004346	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753004347	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753004348	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
438753004349	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753004350	NAD(P) binding site [chemical binding]; other site
438753004351	active site
438753004352	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
438753004353	putative efflux protein, MATE family; Region: matE; TIGR00797
438753004354	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
438753004355	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
438753004356	MarR family; Region: MarR_2; pfam12802
438753004357	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
438753004358	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
438753004359	Fe-S metabolism associated domain; Region: SufE; cl00951
438753004360	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
438753004361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753004362	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753004363	putative substrate translocation pore; other site
438753004364	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
438753004365	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
438753004366	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
438753004367	conserved cys residue [active]
438753004368	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753004369	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
438753004370	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
438753004371	active site
438753004372	catalytic tetrad [active]
438753004373	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
438753004374	TAP-like protein; Region: Abhydrolase_4; pfam08386
438753004375	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
438753004376	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
438753004377	gating phenylalanine in ion channel; other site
438753004378	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
438753004379	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
438753004380	Cytochrome c; Region: Cytochrom_C; pfam00034
438753004381	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
438753004382	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753004383	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
438753004384	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753004385	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753004386	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753004387	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
438753004388	catalytic loop [active]
438753004389	iron binding site [ion binding]; other site
438753004390	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
438753004391	Uncharacterized conserved protein [Function unknown]; Region: COG0397
438753004392	hypothetical protein; Validated; Region: PRK00029
438753004393	haemagglutination activity domain; Region: Haemagg_act; smart00912
438753004394	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
438753004395	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
438753004396	putative catalytic site [active]
438753004397	putative phosphate binding site [ion binding]; other site
438753004398	active site
438753004399	metal binding site A [ion binding]; metal-binding site
438753004400	DNA binding site [nucleotide binding]
438753004401	putative AP binding site [nucleotide binding]; other site
438753004402	putative metal binding site B [ion binding]; other site
438753004403	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
438753004404	DNA-binding site [nucleotide binding]; DNA binding site
438753004405	RNA-binding motif; other site
438753004406	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
438753004407	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
438753004408	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753004409	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
438753004410	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
438753004411	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
438753004412	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753004413	catalytic loop [active]
438753004414	iron binding site [ion binding]; other site
438753004415	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
438753004416	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
438753004417	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
438753004418	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
438753004419	catalytic site [active]
438753004420	active site
438753004421	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
438753004422	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
438753004423	active site
438753004424	catalytic site [active]
438753004425	pyruvate kinase; Provisional; Region: PRK06247
438753004426	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
438753004427	domain interfaces; other site
438753004428	active site
438753004429	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753004430	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753004431	DNA-binding site [nucleotide binding]; DNA binding site
438753004432	FCD domain; Region: FCD; pfam07729
438753004433	dihydroxy-acid dehydratase; Validated; Region: PRK06131
438753004434	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753004435	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753004436	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
438753004437	putative effector binding pocket; other site
438753004438	dimerization interface [polypeptide binding]; other site
438753004439	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
438753004440	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
438753004441	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
438753004442	active site
438753004443	dimer interface [polypeptide binding]; other site
438753004444	metal binding site [ion binding]; metal-binding site
438753004445	hypothetical protein; Provisional; Region: PRK08204
438753004446	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753004447	active site
438753004448	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
438753004449	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
438753004450	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
438753004451	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
438753004452	dimer interface [polypeptide binding]; other site
438753004453	active site
438753004454	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
438753004455	FAD binding domain; Region: FAD_binding_4; pfam01565
438753004456	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
438753004457	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
438753004458	Walker A/P-loop; other site
438753004459	ATP binding site [chemical binding]; other site
438753004460	Q-loop/lid; other site
438753004461	ABC transporter signature motif; other site
438753004462	Walker B; other site
438753004463	D-loop; other site
438753004464	H-loop/switch region; other site
438753004465	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
438753004466	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
438753004467	TM-ABC transporter signature motif; other site
438753004468	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753004469	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
438753004470	TM-ABC transporter signature motif; other site
438753004471	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
438753004472	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
438753004473	ligand binding site [chemical binding]; other site
438753004474	YciI-like protein; Reviewed; Region: PRK12863
438753004475	PAS fold; Region: PAS_4; pfam08448
438753004476	PAS domain S-box; Region: sensory_box; TIGR00229
438753004477	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753004478	putative active site [active]
438753004479	heme pocket [chemical binding]; other site
438753004480	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753004481	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753004482	dimer interface [polypeptide binding]; other site
438753004483	phosphorylation site [posttranslational modification]
438753004484	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753004485	ATP binding site [chemical binding]; other site
438753004486	Mg2+ binding site [ion binding]; other site
438753004487	G-X-G motif; other site
438753004488	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
438753004489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753004490	active site
438753004491	phosphorylation site [posttranslational modification]
438753004492	intermolecular recognition site; other site
438753004493	dimerization interface [polypeptide binding]; other site
438753004494	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
438753004495	dimer interface [polypeptide binding]; other site
438753004496	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
438753004497	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
438753004498	ligand binding site [chemical binding]; other site
438753004499	flexible hinge region; other site
438753004500	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
438753004501	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
438753004502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753004503	putative substrate translocation pore; other site
438753004504	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
438753004505	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
438753004506	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
438753004507	[4Fe-4S] binding site [ion binding]; other site
438753004508	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
438753004509	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
438753004510	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
438753004511	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
438753004512	molybdopterin cofactor binding site; other site
438753004513	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
438753004514	4Fe-4S binding domain; Region: Fer4; cl02805
438753004515	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
438753004516	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
438753004517	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
438753004518	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
438753004519	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753004520	FeS/SAM binding site; other site
438753004521	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
438753004522	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
438753004523	MPT binding site; other site
438753004524	trimer interface [polypeptide binding]; other site
438753004525	Predicted integral membrane protein [Function unknown]; Region: COG5615
438753004526	NnrS protein; Region: NnrS; pfam05940
438753004527	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
438753004528	Multicopper oxidase; Region: Cu-oxidase; pfam00394
438753004529	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
438753004530	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
438753004531	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
438753004532	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
438753004533	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753004534	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753004535	Walker A/P-loop; other site
438753004536	ATP binding site [chemical binding]; other site
438753004537	Q-loop/lid; other site
438753004538	ABC transporter signature motif; other site
438753004539	Walker B; other site
438753004540	D-loop; other site
438753004541	H-loop/switch region; other site
438753004542	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753004543	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753004544	Walker A/P-loop; other site
438753004545	ATP binding site [chemical binding]; other site
438753004546	Q-loop/lid; other site
438753004547	ABC transporter signature motif; other site
438753004548	Walker B; other site
438753004549	D-loop; other site
438753004550	H-loop/switch region; other site
438753004551	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753004552	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753004553	TM-ABC transporter signature motif; other site
438753004554	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753004555	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753004556	TM-ABC transporter signature motif; other site
438753004557	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
438753004558	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
438753004559	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975
438753004560	tetramer interface [polypeptide binding]; other site
438753004561	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
438753004562	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
438753004563	heterodimer interface [polypeptide binding]; other site
438753004564	active site
438753004565	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
438753004566	heterodimer interface [polypeptide binding]; other site
438753004567	multimer interface [polypeptide binding]; other site
438753004568	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
438753004569	active site
438753004570	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
438753004571	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
438753004572	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
438753004573	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753004574	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753004575	dimerization interface [polypeptide binding]; other site
438753004576	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
438753004577	Dehydroquinase class II; Region: DHquinase_II; pfam01220
438753004578	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
438753004579	active site
438753004580	trimer interface [polypeptide binding]; other site
438753004581	dimer interface [polypeptide binding]; other site
438753004582	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
438753004583	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753004584	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753004585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753004586	dimer interface [polypeptide binding]; other site
438753004587	conserved gate region; other site
438753004588	putative PBP binding loops; other site
438753004589	ABC-ATPase subunit interface; other site
438753004590	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753004591	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753004592	dimer interface [polypeptide binding]; other site
438753004593	conserved gate region; other site
438753004594	putative PBP binding loops; other site
438753004595	ABC-ATPase subunit interface; other site
438753004596	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753004597	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753004598	substrate binding pocket [chemical binding]; other site
438753004599	membrane-bound complex binding site; other site
438753004600	hinge residues; other site
438753004601	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753004602	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753004603	Walker A/P-loop; other site
438753004604	ATP binding site [chemical binding]; other site
438753004605	Q-loop/lid; other site
438753004606	ABC transporter signature motif; other site
438753004607	Walker B; other site
438753004608	D-loop; other site
438753004609	H-loop/switch region; other site
438753004610	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
438753004611	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
438753004612	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
438753004613	shikimate binding site; other site
438753004614	NAD(P) binding site [chemical binding]; other site
438753004615	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
438753004616	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
438753004617	DNA interaction; other site
438753004618	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
438753004619	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
438753004620	dimer interface [polypeptide binding]; other site
438753004621	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
438753004622	active site
438753004623	Fe binding site [ion binding]; other site
438753004624	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
438753004625	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
438753004626	metal-binding site [ion binding]
438753004627	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
438753004628	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
438753004629	Soluble P-type ATPase [General function prediction only]; Region: COG4087
438753004630	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
438753004631	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
438753004632	DNA binding residues [nucleotide binding]
438753004633	dimer interface [polypeptide binding]; other site
438753004634	putative metal binding site [ion binding]; other site
438753004635	Predicted acetyltransferase [General function prediction only]; Region: COG2388
438753004636	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
438753004637	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
438753004638	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
438753004639	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
438753004640	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
438753004641	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
438753004642	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
438753004643	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
438753004644	RNA/DNA hybrid binding site [nucleotide binding]; other site
438753004645	active site
438753004646	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
438753004647	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
438753004648	putative active site [active]
438753004649	putative substrate binding site [chemical binding]; other site
438753004650	ATP binding site [chemical binding]; other site
438753004651	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
438753004652	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
438753004653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
438753004654	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
438753004655	Ligand Binding Site [chemical binding]; other site
438753004656	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
438753004657	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
438753004658	Ligand binding site; other site
438753004659	Putative Catalytic site; other site
438753004660	DXD motif; other site
438753004661	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
438753004662	putative active site [active]
438753004663	YdjC motif; other site
438753004664	Mg binding site [ion binding]; other site
438753004665	putative homodimer interface [polypeptide binding]; other site
438753004666	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
438753004667	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
438753004668	putative ion selectivity filter; other site
438753004669	putative pore gating glutamate residue; other site
438753004670	putative H+/Cl- coupling transport residue; other site
438753004671	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
438753004672	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
438753004673	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
438753004674	acyl-CoA synthetase; Validated; Region: PRK08162
438753004675	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
438753004676	acyl-activating enzyme (AAE) consensus motif; other site
438753004677	putative active site [active]
438753004678	AMP binding site [chemical binding]; other site
438753004679	putative CoA binding site [chemical binding]; other site
438753004680	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
438753004681	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
438753004682	acyl-activating enzyme (AAE) consensus motif; other site
438753004683	putative AMP binding site [chemical binding]; other site
438753004684	putative active site [active]
438753004685	putative CoA binding site [chemical binding]; other site
438753004686	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
438753004687	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
438753004688	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
438753004689	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
438753004690	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
438753004691	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
438753004692	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
438753004693	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
438753004694	Transcriptional regulator [Transcription]; Region: IclR; COG1414
438753004695	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753004696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753004697	metabolite-proton symporter; Region: 2A0106; TIGR00883
438753004698	putative substrate translocation pore; other site
438753004699	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
438753004700	classical (c) SDRs; Region: SDR_c; cd05233
438753004701	NAD(P) binding site [chemical binding]; other site
438753004702	active site
438753004703	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
438753004704	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
438753004705	active site
438753004706	catalytic site [active]
438753004707	Zn binding site [ion binding]; other site
438753004708	tetramer interface [polypeptide binding]; other site
438753004709	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
438753004710	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
438753004711	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
438753004712	putative active site [active]
438753004713	putative substrate binding site [chemical binding]; other site
438753004714	putative cosubstrate binding site; other site
438753004715	catalytic site [active]
438753004716	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
438753004717	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
438753004718	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
438753004719	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
438753004720	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
438753004721	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
438753004722	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
438753004723	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
438753004724	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
438753004725	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
438753004726	conserved cys residue [active]
438753004727	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753004728	Cupin domain; Region: Cupin_2; cl17218
438753004729	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
438753004730	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
438753004731	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
438753004732	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
438753004733	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
438753004734	active site
438753004735	FMN binding site [chemical binding]; other site
438753004736	substrate binding site [chemical binding]; other site
438753004737	3Fe-4S cluster binding site [ion binding]; other site
438753004738	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
438753004739	domain_subunit interface; other site
438753004740	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
438753004741	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
438753004742	putative active site [active]
438753004743	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753004744	non-specific DNA binding site [nucleotide binding]; other site
438753004745	salt bridge; other site
438753004746	sequence-specific DNA binding site [nucleotide binding]; other site
438753004747	Cupin domain; Region: Cupin_2; pfam07883
438753004748	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
438753004749	catalytic triad [active]
438753004750	putative active site [active]
438753004751	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
438753004752	catalytic residues [active]
438753004753	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753004754	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753004755	Autotransporter beta-domain; Region: Autotransporter; smart00869
438753004756	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
438753004757	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753004758	dimerization interface [polypeptide binding]; other site
438753004759	putative DNA binding site [nucleotide binding]; other site
438753004760	putative Zn2+ binding site [ion binding]; other site
438753004761	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
438753004762	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
438753004763	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
438753004764	Walker A/P-loop; other site
438753004765	ATP binding site [chemical binding]; other site
438753004766	Q-loop/lid; other site
438753004767	ABC transporter signature motif; other site
438753004768	Walker B; other site
438753004769	D-loop; other site
438753004770	H-loop/switch region; other site
438753004771	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
438753004772	active site
438753004773	cosubstrate binding site; other site
438753004774	substrate binding site [chemical binding]; other site
438753004775	catalytic site [active]
438753004776	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
438753004777	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
438753004778	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
438753004779	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
438753004780	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
438753004781	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753004782	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753004783	dimer interface [polypeptide binding]; other site
438753004784	conserved gate region; other site
438753004785	putative PBP binding loops; other site
438753004786	ABC-ATPase subunit interface; other site
438753004787	D-ala-D-ala transporter subunit; Provisional; Region: PRK09881
438753004788	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753004789	dimer interface [polypeptide binding]; other site
438753004790	conserved gate region; other site
438753004791	putative PBP binding loops; other site
438753004792	ABC-ATPase subunit interface; other site
438753004793	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
438753004794	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753004795	Walker A/P-loop; other site
438753004796	ATP binding site [chemical binding]; other site
438753004797	Q-loop/lid; other site
438753004798	ABC transporter signature motif; other site
438753004799	Walker B; other site
438753004800	D-loop; other site
438753004801	H-loop/switch region; other site
438753004802	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
438753004803	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753004804	Walker A/P-loop; other site
438753004805	ATP binding site [chemical binding]; other site
438753004806	Q-loop/lid; other site
438753004807	ABC transporter signature motif; other site
438753004808	Walker B; other site
438753004809	D-loop; other site
438753004810	H-loop/switch region; other site
438753004811	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753004812	amidase; Provisional; Region: PRK09201
438753004813	Amidase; Region: Amidase; cl11426
438753004814	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
438753004815	Transcriptional regulators [Transcription]; Region: FadR; COG2186
438753004816	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753004817	DNA-binding site [nucleotide binding]; DNA binding site
438753004818	FCD domain; Region: FCD; pfam07729
438753004819	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
438753004820	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753004821	S-adenosylmethionine binding site [chemical binding]; other site
438753004822	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
438753004823	Methyltransferase domain; Region: Methyltransf_24; pfam13578
438753004824	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753004825	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
438753004826	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
438753004827	active site
438753004828	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
438753004829	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753004830	NAD(P) binding site [chemical binding]; other site
438753004831	active site
438753004832	allophanate hydrolase; Provisional; Region: PRK08186
438753004833	Amidase; Region: Amidase; cl11426
438753004834	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
438753004835	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
438753004836	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
438753004837	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
438753004838	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
438753004839	Moco binding site; other site
438753004840	metal coordination site [ion binding]; other site
438753004841	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
438753004842	dimer interface [polypeptide binding]; other site
438753004843	active site
438753004844	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
438753004845	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
438753004846	active site
438753004847	DNA binding site [nucleotide binding]
438753004848	Int/Topo IB signature motif; other site
438753004849	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
438753004850	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
438753004851	catalytic residues [active]
438753004852	catalytic nucleophile [active]
438753004853	Recombinase; Region: Recombinase; pfam07508
438753004854	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
438753004855	active site
438753004856	RNA/DNA hybrid binding site [nucleotide binding]; other site
438753004857	enoyl-CoA hydratase; Provisional; Region: PRK06127
438753004858	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
438753004859	substrate binding site [chemical binding]; other site
438753004860	oxyanion hole (OAH) forming residues; other site
438753004861	trimer interface [polypeptide binding]; other site
438753004862	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
438753004863	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
438753004864	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
438753004865	putative substrate binding pocket [chemical binding]; other site
438753004866	AC domain interface; other site
438753004867	catalytic triad [active]
438753004868	AB domain interface; other site
438753004869	membrane ATPase/protein kinase; Provisional; Region: PRK09435
438753004870	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
438753004871	Walker A; other site
438753004872	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
438753004873	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
438753004874	MarC family integral membrane protein; Region: MarC; cl00919
438753004875	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
438753004876	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
438753004877	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
438753004878	RDD family; Region: RDD; pfam06271
438753004879	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753004880	TM-ABC transporter signature motif; other site
438753004881	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
438753004882	dimer interface [polypeptide binding]; other site
438753004883	active site
438753004884	aspartate-rich active site metal binding site; other site
438753004885	allosteric magnesium binding site [ion binding]; other site
438753004886	Schiff base residues; other site
438753004887	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
438753004888	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
438753004889	substrate binding site [chemical binding]; other site
438753004890	oxyanion hole (OAH) forming residues; other site
438753004891	trimer interface [polypeptide binding]; other site
438753004892	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
438753004893	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753004894	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753004895	dimer interface [polypeptide binding]; other site
438753004896	putative CheW interface [polypeptide binding]; other site
438753004897	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
438753004898	allantoate amidohydrolase; Reviewed; Region: PRK09290
438753004899	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
438753004900	active site
438753004901	metal binding site [ion binding]; metal-binding site
438753004902	dimer interface [polypeptide binding]; other site
438753004903	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
438753004904	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753004905	Walker A/P-loop; other site
438753004906	ATP binding site [chemical binding]; other site
438753004907	Q-loop/lid; other site
438753004908	ABC transporter signature motif; other site
438753004909	Walker B; other site
438753004910	D-loop; other site
438753004911	H-loop/switch region; other site
438753004912	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753004913	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753004914	Amidase; Region: Amidase; cl11426
438753004915	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
438753004916	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753004917	Walker A/P-loop; other site
438753004918	ATP binding site [chemical binding]; other site
438753004919	Q-loop/lid; other site
438753004920	ABC transporter signature motif; other site
438753004921	Walker B; other site
438753004922	D-loop; other site
438753004923	H-loop/switch region; other site
438753004924	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
438753004925	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
438753004926	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753004927	dimer interface [polypeptide binding]; other site
438753004928	conserved gate region; other site
438753004929	putative PBP binding loops; other site
438753004930	ABC-ATPase subunit interface; other site
438753004931	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753004932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753004933	dimer interface [polypeptide binding]; other site
438753004934	conserved gate region; other site
438753004935	putative PBP binding loops; other site
438753004936	ABC-ATPase subunit interface; other site
438753004937	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753004938	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
438753004939	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
438753004940	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
438753004941	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
438753004942	active site
438753004943	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
438753004944	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753004945	dimerization interface [polypeptide binding]; other site
438753004946	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753004947	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753004948	dimer interface [polypeptide binding]; other site
438753004949	putative CheW interface [polypeptide binding]; other site
438753004950	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
438753004951	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
438753004952	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
438753004953	Soluble P-type ATPase [General function prediction only]; Region: COG4087
438753004954	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
438753004955	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
438753004956	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
438753004957	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
438753004958	Ligand Binding Site [chemical binding]; other site
438753004959	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
438753004960	GAF domain; Region: GAF_3; pfam13492
438753004961	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753004962	dimer interface [polypeptide binding]; other site
438753004963	phosphorylation site [posttranslational modification]
438753004964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753004965	ATP binding site [chemical binding]; other site
438753004966	Mg2+ binding site [ion binding]; other site
438753004967	G-X-G motif; other site
438753004968	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753004969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753004970	active site
438753004971	phosphorylation site [posttranslational modification]
438753004972	intermolecular recognition site; other site
438753004973	dimerization interface [polypeptide binding]; other site
438753004974	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753004975	DNA binding site [nucleotide binding]
438753004976	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
438753004977	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
438753004978	nucleotide binding site [chemical binding]; other site
438753004979	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
438753004980	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
438753004981	NAD binding site [chemical binding]; other site
438753004982	putative substrate binding site 2 [chemical binding]; other site
438753004983	putative substrate binding site 1 [chemical binding]; other site
438753004984	active site
438753004985	potassium/proton antiporter; Reviewed; Region: PRK05326
438753004986	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
438753004987	Transporter associated domain; Region: CorC_HlyC; cl08393
438753004988	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
438753004989	hypothetical protein; Provisional; Region: PRK08912
438753004990	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753004991	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753004992	homodimer interface [polypeptide binding]; other site
438753004993	catalytic residue [active]
438753004994	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
438753004995	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753004996	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753004997	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
438753004998	Protein export membrane protein; Region: SecD_SecF; cl14618
438753004999	Hemin uptake protein hemP; Region: hemP; pfam10636
438753005000	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753005001	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
438753005002	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
438753005003	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
438753005004	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
438753005005	active site
438753005006	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
438753005007	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
438753005008	active site
438753005009	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
438753005010	cystathionine beta-lyase; Provisional; Region: PRK05967
438753005011	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
438753005012	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
438753005013	catalytic residue [active]
438753005014	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
438753005015	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753005016	substrate binding pocket [chemical binding]; other site
438753005017	membrane-bound complex binding site; other site
438753005018	hinge residues; other site
438753005019	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
438753005020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753005021	conserved gate region; other site
438753005022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753005023	putative PBP binding loops; other site
438753005024	dimer interface [polypeptide binding]; other site
438753005025	ABC-ATPase subunit interface; other site
438753005026	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753005027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753005028	dimer interface [polypeptide binding]; other site
438753005029	conserved gate region; other site
438753005030	putative PBP binding loops; other site
438753005031	ABC-ATPase subunit interface; other site
438753005032	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753005033	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753005034	Walker A/P-loop; other site
438753005035	ATP binding site [chemical binding]; other site
438753005036	Q-loop/lid; other site
438753005037	ABC transporter signature motif; other site
438753005038	Walker B; other site
438753005039	D-loop; other site
438753005040	H-loop/switch region; other site
438753005041	Pantoate-beta-alanine ligase; Region: PanC; cd00560
438753005042	pantoate--beta-alanine ligase; Region: panC; TIGR00018
438753005043	active site
438753005044	ATP-binding site [chemical binding]; other site
438753005045	pantoate-binding site; other site
438753005046	HXXH motif; other site
438753005047	von Willebrand factor type A domain; Region: VWA_2; pfam13519
438753005048	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
438753005049	HSP70 interaction site [polypeptide binding]; other site
438753005050	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
438753005051	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
438753005052	Sporulation related domain; Region: SPOR; pfam05036
438753005053	Phasin protein; Region: Phasin_2; pfam09361
438753005054	Uncharacterized conserved protein [Function unknown]; Region: COG2127
438753005055	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
438753005056	Clp amino terminal domain; Region: Clp_N; pfam02861
438753005057	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753005058	Walker A motif; other site
438753005059	ATP binding site [chemical binding]; other site
438753005060	Walker B motif; other site
438753005061	arginine finger; other site
438753005062	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753005063	Walker A motif; other site
438753005064	ATP binding site [chemical binding]; other site
438753005065	Walker B motif; other site
438753005066	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
438753005067	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
438753005068	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
438753005069	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
438753005070	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
438753005071	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753005072	catalytic residue [active]
438753005073	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
438753005074	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
438753005075	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
438753005076	glutamine synthetase; Provisional; Region: glnA; PRK09469
438753005077	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
438753005078	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
438753005079	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
438753005080	Nitrogen regulatory protein P-II; Region: P-II; smart00938
438753005081	Uncharacterized conserved protein [Function unknown]; Region: COG0062
438753005082	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
438753005083	putative substrate binding site [chemical binding]; other site
438753005084	putative ATP binding site [chemical binding]; other site
438753005085	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
438753005086	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
438753005087	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
438753005088	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
438753005089	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
438753005090	active site
438753005091	catalytic tetrad [active]
438753005092	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753005093	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753005094	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
438753005095	putative effector binding pocket; other site
438753005096	putative dimerization interface [polypeptide binding]; other site
438753005097	trigger factor; Provisional; Region: tig; PRK01490
438753005098	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
438753005099	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
438753005100	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
438753005101	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
438753005102	oligomer interface [polypeptide binding]; other site
438753005103	active site residues [active]
438753005104	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
438753005105	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
438753005106	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753005107	Walker A motif; other site
438753005108	ATP binding site [chemical binding]; other site
438753005109	Walker B motif; other site
438753005110	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
438753005111	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
438753005112	Found in ATP-dependent protease La (LON); Region: LON; smart00464
438753005113	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753005114	Walker A motif; other site
438753005115	ATP binding site [chemical binding]; other site
438753005116	Walker B motif; other site
438753005117	arginine finger; other site
438753005118	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
438753005119	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
438753005120	IHF dimer interface [polypeptide binding]; other site
438753005121	IHF - DNA interface [nucleotide binding]; other site
438753005122	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
438753005123	benzoate transport; Region: 2A0115; TIGR00895
438753005124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753005125	putative substrate translocation pore; other site
438753005126	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
438753005127	active site
438753005128	substrate binding pocket [chemical binding]; other site
438753005129	dimer interface [polypeptide binding]; other site
438753005130	PilZ domain; Region: PilZ; pfam07238
438753005131	Domain of unknown function (DUF892); Region: DUF892; pfam05974
438753005132	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
438753005133	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
438753005134	active site
438753005135	substrate binding site [chemical binding]; other site
438753005136	FMN binding site [chemical binding]; other site
438753005137	putative catalytic residues [active]
438753005138	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
438753005139	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
438753005140	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
438753005141	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
438753005142	Walker A/P-loop; other site
438753005143	ATP binding site [chemical binding]; other site
438753005144	Q-loop/lid; other site
438753005145	ABC transporter signature motif; other site
438753005146	Walker B; other site
438753005147	D-loop; other site
438753005148	H-loop/switch region; other site
438753005149	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
438753005150	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
438753005151	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
438753005152	FAD binding pocket [chemical binding]; other site
438753005153	FAD binding motif [chemical binding]; other site
438753005154	phosphate binding motif [ion binding]; other site
438753005155	NAD binding pocket [chemical binding]; other site
438753005156	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
438753005157	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
438753005158	ABC-ATPase subunit  interface; other site
438753005159	dimer interface [polypeptide binding]; other site
438753005160	putative PBP binding regions; other site
438753005161	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
438753005162	ABC-ATPase subunit  interface; other site
438753005163	putative PBP binding regions; other site
438753005164	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
438753005165	intersubunit interface [polypeptide binding]; other site
438753005166	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
438753005167	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
438753005168	Walker A/P-loop; other site
438753005169	ATP binding site [chemical binding]; other site
438753005170	Q-loop/lid; other site
438753005171	ABC transporter signature motif; other site
438753005172	Walker B; other site
438753005173	D-loop; other site
438753005174	H-loop/switch region; other site
438753005175	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
438753005176	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
438753005177	N-terminal plug; other site
438753005178	ligand-binding site [chemical binding]; other site
438753005179	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
438753005180	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753005181	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
438753005182	Protein of unknown function (DUF815); Region: DUF815; pfam05673
438753005183	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
438753005184	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
438753005185	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
438753005186	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
438753005187	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
438753005188	N-terminal plug; other site
438753005189	ligand-binding site [chemical binding]; other site
438753005190	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
438753005191	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
438753005192	FMN binding site [chemical binding]; other site
438753005193	active site
438753005194	catalytic residues [active]
438753005195	substrate binding site [chemical binding]; other site
438753005196	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
438753005197	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
438753005198	active site
438753005199	catalytic site [active]
438753005200	tetramer interface [polypeptide binding]; other site
438753005201	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753005202	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753005203	DNA-binding site [nucleotide binding]; DNA binding site
438753005204	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
438753005205	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
438753005206	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
438753005207	Predicted integral membrane protein [Function unknown]; Region: COG5616
438753005208	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753005209	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
438753005210	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
438753005211	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
438753005212	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
438753005213	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
438753005214	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753005215	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753005216	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
438753005217	Mechanosensitive ion channel; Region: MS_channel; pfam00924
438753005218	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
438753005219	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
438753005220	ligand binding site [chemical binding]; other site
438753005221	flexible hinge region; other site
438753005222	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
438753005223	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
438753005224	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
438753005225	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
438753005226	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
438753005227	inhibitor-cofactor binding pocket; inhibition site
438753005228	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753005229	catalytic residue [active]
438753005230	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
438753005231	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
438753005232	Esterase/lipase [General function prediction only]; Region: COG1647
438753005233	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
438753005234	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
438753005235	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
438753005236	HAMP domain; Region: HAMP; pfam00672
438753005237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753005238	dimer interface [polypeptide binding]; other site
438753005239	phosphorylation site [posttranslational modification]
438753005240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753005241	ATP binding site [chemical binding]; other site
438753005242	G-X-G motif; other site
438753005243	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
438753005244	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753005245	active site
438753005246	phosphorylation site [posttranslational modification]
438753005247	intermolecular recognition site; other site
438753005248	dimerization interface [polypeptide binding]; other site
438753005249	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753005250	Walker A motif; other site
438753005251	ATP binding site [chemical binding]; other site
438753005252	Walker B motif; other site
438753005253	arginine finger; other site
438753005254	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
438753005255	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
438753005256	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
438753005257	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
438753005258	phosphate binding site [ion binding]; other site
438753005259	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
438753005260	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
438753005261	homodimer interface [polypeptide binding]; other site
438753005262	metal binding site [ion binding]; metal-binding site
438753005263	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
438753005264	homodimer interface [polypeptide binding]; other site
438753005265	active site
438753005266	putative chemical substrate binding site [chemical binding]; other site
438753005267	metal binding site [ion binding]; metal-binding site
438753005268	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
438753005269	homodimer interaction site [polypeptide binding]; other site
438753005270	cofactor binding site; other site
438753005271	hypothetical protein; Provisional; Region: PRK05415
438753005272	Domain of unknown function (DUF697); Region: DUF697; cl12064
438753005273	YcjX-like family, DUF463; Region: DUF463; pfam04317
438753005274	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
438753005275	catalytic core [active]
438753005276	FAD dependent oxidoreductase; Region: DAO; pfam01266
438753005277	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
438753005278	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
438753005279	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
438753005280	PAS domain S-box; Region: sensory_box; TIGR00229
438753005281	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753005282	dimer interface [polypeptide binding]; other site
438753005283	phosphorylation site [posttranslational modification]
438753005284	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753005285	ATP binding site [chemical binding]; other site
438753005286	Mg2+ binding site [ion binding]; other site
438753005287	G-X-G motif; other site
438753005288	Response regulator receiver domain; Region: Response_reg; pfam00072
438753005289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753005290	active site
438753005291	phosphorylation site [posttranslational modification]
438753005292	intermolecular recognition site; other site
438753005293	dimerization interface [polypeptide binding]; other site
438753005294	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
438753005295	NADH dehydrogenase subunit B; Validated; Region: PRK06411
438753005296	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
438753005297	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
438753005298	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
438753005299	NADH dehydrogenase subunit D; Validated; Region: PRK06075
438753005300	NADH dehydrogenase subunit E; Validated; Region: PRK07539
438753005301	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
438753005302	putative dimer interface [polypeptide binding]; other site
438753005303	[2Fe-2S] cluster binding site [ion binding]; other site
438753005304	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
438753005305	SLBB domain; Region: SLBB; pfam10531
438753005306	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
438753005307	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
438753005308	NADH dehydrogenase subunit G; Validated; Region: PRK09130
438753005309	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753005310	catalytic loop [active]
438753005311	iron binding site [ion binding]; other site
438753005312	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
438753005313	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
438753005314	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
438753005315	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
438753005316	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
438753005317	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
438753005318	4Fe-4S binding domain; Region: Fer4; cl02805
438753005319	4Fe-4S binding domain; Region: Fer4; pfam00037
438753005320	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
438753005321	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
438753005322	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
438753005323	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
438753005324	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
438753005325	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
438753005326	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
438753005327	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
438753005328	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
438753005329	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
438753005330	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
438753005331	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
438753005332	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
438753005333	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
438753005334	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
438753005335	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
438753005336	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
438753005337	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753005338	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
438753005339	dimer interface [polypeptide binding]; other site
438753005340	substrate binding site [chemical binding]; other site
438753005341	metal binding site [ion binding]; metal-binding site
438753005342	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
438753005343	prolyl-tRNA synthetase; Provisional; Region: PRK12325
438753005344	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
438753005345	dimer interface [polypeptide binding]; other site
438753005346	motif 1; other site
438753005347	active site
438753005348	motif 2; other site
438753005349	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
438753005350	active site
438753005351	motif 3; other site
438753005352	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
438753005353	anticodon binding site; other site
438753005354	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
438753005355	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
438753005356	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
438753005357	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
438753005358	Walker A/P-loop; other site
438753005359	ATP binding site [chemical binding]; other site
438753005360	Q-loop/lid; other site
438753005361	ABC transporter signature motif; other site
438753005362	Walker B; other site
438753005363	D-loop; other site
438753005364	H-loop/switch region; other site
438753005365	Predicted membrane protein [Function unknown]; Region: COG2510
438753005366	Protein of unknown function (DUF3620); Region: DUF3620; pfam12281
438753005367	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
438753005368	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
438753005369	putative active site [active]
438753005370	putative PHP Thumb interface [polypeptide binding]; other site
438753005371	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
438753005372	generic binding surface II; other site
438753005373	generic binding surface I; other site
438753005374	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
438753005375	active site
438753005376	catalytic triad [active]
438753005377	calcium binding site [ion binding]; other site
438753005378	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
438753005379	30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311
438753005380	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
438753005381	rRNA interaction site [nucleotide binding]; other site
438753005382	S8 interaction site; other site
438753005383	putative laminin-1 binding site; other site
438753005384	Uncharacterized conserved protein [Function unknown]; Region: COG3743
438753005385	elongation factor Ts; Provisional; Region: tsf; PRK09377
438753005386	UBA/TS-N domain; Region: UBA; pfam00627
438753005387	Elongation factor TS; Region: EF_TS; pfam00889
438753005388	Elongation factor TS; Region: EF_TS; pfam00889
438753005389	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
438753005390	putative nucleotide binding site [chemical binding]; other site
438753005391	uridine monophosphate binding site [chemical binding]; other site
438753005392	homohexameric interface [polypeptide binding]; other site
438753005393	ribosome recycling factor; Reviewed; Region: frr; PRK00083
438753005394	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
438753005395	hinge region; other site
438753005396	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
438753005397	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
438753005398	catalytic residue [active]
438753005399	putative FPP diphosphate  binding site; other site
438753005400	putative FPP binding hydrophobic cleft; other site
438753005401	dimer interface [polypeptide binding]; other site
438753005402	putative IPP diphosphate binding site; other site
438753005403	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
438753005404	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
438753005405	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
438753005406	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
438753005407	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
438753005408	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
438753005409	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
438753005410	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
438753005411	active site
438753005412	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
438753005413	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
438753005414	putative substrate binding region [chemical binding]; other site
438753005415	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
438753005416	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
438753005417	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
438753005418	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
438753005419	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
438753005420	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
438753005421	Surface antigen; Region: Bac_surface_Ag; pfam01103
438753005422	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
438753005423	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
438753005424	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
438753005425	trimer interface [polypeptide binding]; other site
438753005426	active site
438753005427	UDP-GlcNAc binding site [chemical binding]; other site
438753005428	lipid binding site [chemical binding]; lipid-binding site
438753005429	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
438753005430	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
438753005431	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
438753005432	active site
438753005433	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
438753005434	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
438753005435	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
438753005436	LysR family transcriptional regulator; Provisional; Region: PRK14997
438753005437	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753005438	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
438753005439	putative effector binding pocket; other site
438753005440	putative dimerization interface [polypeptide binding]; other site
438753005441	short chain dehydrogenase; Provisional; Region: PRK06500
438753005442	classical (c) SDRs; Region: SDR_c; cd05233
438753005443	NAD(P) binding site [chemical binding]; other site
438753005444	active site
438753005445	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
438753005446	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
438753005447	dimer interface [polypeptide binding]; other site
438753005448	active site
438753005449	citrylCoA binding site [chemical binding]; other site
438753005450	NADH binding [chemical binding]; other site
438753005451	cationic pore residues; other site
438753005452	oxalacetate/citrate binding site [chemical binding]; other site
438753005453	coenzyme A binding site [chemical binding]; other site
438753005454	catalytic triad [active]
438753005455	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
438753005456	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
438753005457	GTP binding site; other site
438753005458	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
438753005459	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
438753005460	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
438753005461	active site
438753005462	hypothetical protein; Provisional; Region: PRK09133
438753005463	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
438753005464	TonB C terminal; Region: TonB_2; pfam13103
438753005465	Gram-negative bacterial tonB protein; Region: TonB; cl10048
438753005466	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
438753005467	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
438753005468	Substrate binding site; other site
438753005469	Mg++ binding site; other site
438753005470	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
438753005471	active site
438753005472	substrate binding site [chemical binding]; other site
438753005473	CoA binding site [chemical binding]; other site
438753005474	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
438753005475	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
438753005476	glutaminase active site [active]
438753005477	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
438753005478	dimer interface [polypeptide binding]; other site
438753005479	active site
438753005480	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
438753005481	dimer interface [polypeptide binding]; other site
438753005482	active site
438753005483	YcxB-like protein; Region: YcxB; pfam14317
438753005484	CHASE3 domain; Region: CHASE3; pfam05227
438753005485	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
438753005486	dimerization interface [polypeptide binding]; other site
438753005487	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753005488	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753005489	dimer interface [polypeptide binding]; other site
438753005490	putative CheW interface [polypeptide binding]; other site
438753005491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
438753005492	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
438753005493	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
438753005494	generic binding surface II; other site
438753005495	ssDNA binding site; other site
438753005496	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
438753005497	ATP binding site [chemical binding]; other site
438753005498	putative Mg++ binding site [ion binding]; other site
438753005499	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
438753005500	nucleotide binding region [chemical binding]; other site
438753005501	ATP-binding site [chemical binding]; other site
438753005502	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
438753005503	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
438753005504	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
438753005505	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
438753005506	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
438753005507	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753005508	S-adenosylmethionine binding site [chemical binding]; other site
438753005509	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
438753005510	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
438753005511	N-terminal plug; other site
438753005512	ligand-binding site [chemical binding]; other site
438753005513	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
438753005514	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
438753005515	Peptidase family M23; Region: Peptidase_M23; pfam01551
438753005516	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
438753005517	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
438753005518	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
438753005519	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
438753005520	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
438753005521	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
438753005522	Walker A/P-loop; other site
438753005523	ATP binding site [chemical binding]; other site
438753005524	Q-loop/lid; other site
438753005525	ABC transporter signature motif; other site
438753005526	Walker B; other site
438753005527	D-loop; other site
438753005528	H-loop/switch region; other site
438753005529	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
438753005530	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
438753005531	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
438753005532	seryl-tRNA synthetase; Provisional; Region: PRK05431
438753005533	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
438753005534	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
438753005535	dimer interface [polypeptide binding]; other site
438753005536	active site
438753005537	motif 1; other site
438753005538	motif 2; other site
438753005539	motif 3; other site
438753005540	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
438753005541	Septum formation initiator; Region: DivIC; pfam04977
438753005542	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
438753005543	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
438753005544	tetramer interface [polypeptide binding]; other site
438753005545	TPP-binding site [chemical binding]; other site
438753005546	heterodimer interface [polypeptide binding]; other site
438753005547	phosphorylation loop region [posttranslational modification]
438753005548	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
438753005549	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
438753005550	E3 interaction surface; other site
438753005551	lipoyl attachment site [posttranslational modification]; other site
438753005552	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
438753005553	alpha subunit interface [polypeptide binding]; other site
438753005554	TPP binding site [chemical binding]; other site
438753005555	heterodimer interface [polypeptide binding]; other site
438753005556	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
438753005557	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
438753005558	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
438753005559	E3 interaction surface; other site
438753005560	lipoyl attachment site [posttranslational modification]; other site
438753005561	e3 binding domain; Region: E3_binding; pfam02817
438753005562	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
438753005563	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
438753005564	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
438753005565	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
438753005566	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
438753005567	lipoyl synthase; Provisional; Region: PRK05481
438753005568	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753005569	FeS/SAM binding site; other site
438753005570	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
438753005571	putative coenzyme Q binding site [chemical binding]; other site
438753005572	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
438753005573	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
438753005574	Tetramer interface [polypeptide binding]; other site
438753005575	active site
438753005576	FMN-binding site [chemical binding]; other site
438753005577	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
438753005578	Domain of unknown function DUF21; Region: DUF21; pfam01595
438753005579	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
438753005580	Transporter associated domain; Region: CorC_HlyC; smart01091
438753005581	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
438753005582	catalytic core [active]
438753005583	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
438753005584	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
438753005585	NAD binding site [chemical binding]; other site
438753005586	homotetramer interface [polypeptide binding]; other site
438753005587	homodimer interface [polypeptide binding]; other site
438753005588	substrate binding site [chemical binding]; other site
438753005589	active site
438753005590	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
438753005591	MgtE intracellular N domain; Region: MgtE_N; pfam03448
438753005592	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
438753005593	Divalent cation transporter; Region: MgtE; pfam01769
438753005594	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
438753005595	active site
438753005596	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753005597	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
438753005598	putative ligand binding site [chemical binding]; other site
438753005599	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753005600	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753005601	TM-ABC transporter signature motif; other site
438753005602	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753005603	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753005604	TM-ABC transporter signature motif; other site
438753005605	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
438753005606	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753005607	Walker A/P-loop; other site
438753005608	ATP binding site [chemical binding]; other site
438753005609	Q-loop/lid; other site
438753005610	ABC transporter signature motif; other site
438753005611	Walker B; other site
438753005612	D-loop; other site
438753005613	H-loop/switch region; other site
438753005614	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
438753005615	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753005616	Walker A/P-loop; other site
438753005617	ATP binding site [chemical binding]; other site
438753005618	Q-loop/lid; other site
438753005619	ABC transporter signature motif; other site
438753005620	Walker B; other site
438753005621	D-loop; other site
438753005622	H-loop/switch region; other site
438753005623	UreD urease accessory protein; Region: UreD; pfam01774
438753005624	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
438753005625	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
438753005626	alpha-gamma subunit interface [polypeptide binding]; other site
438753005627	beta-gamma subunit interface [polypeptide binding]; other site
438753005628	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
438753005629	alpha-beta subunit interface [polypeptide binding]; other site
438753005630	Uncharacterized conserved protein [Function unknown]; Region: COG3791
438753005631	urease subunit alpha; Reviewed; Region: ureC; PRK13207
438753005632	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
438753005633	subunit interactions [polypeptide binding]; other site
438753005634	active site
438753005635	flap region; other site
438753005636	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
438753005637	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
438753005638	dimer interface [polypeptide binding]; other site
438753005639	catalytic residues [active]
438753005640	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
438753005641	UreF; Region: UreF; pfam01730
438753005642	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
438753005643	Protein of unknown function (DUF938); Region: DUF938; pfam06080
438753005644	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
438753005645	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
438753005646	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
438753005647	active site
438753005648	substrate binding site [chemical binding]; other site
438753005649	coenzyme B12 binding site [chemical binding]; other site
438753005650	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
438753005651	B12 binding site [chemical binding]; other site
438753005652	cobalt ligand [ion binding]; other site
438753005653	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
438753005654	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
438753005655	heterodimer interface [polypeptide binding]; other site
438753005656	substrate interaction site [chemical binding]; other site
438753005657	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
438753005658	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
438753005659	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
438753005660	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
438753005661	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
438753005662	carboxyltransferase (CT) interaction site; other site
438753005663	biotinylation site [posttranslational modification]; other site
438753005664	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
438753005665	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
438753005666	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
438753005667	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
438753005668	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753005669	non-specific DNA binding site [nucleotide binding]; other site
438753005670	salt bridge; other site
438753005671	sequence-specific DNA binding site [nucleotide binding]; other site
438753005672	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
438753005673	Domain of unknown function (DUF955); Region: DUF955; pfam06114
438753005674	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
438753005675	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753005676	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
438753005677	Bacterial SH3 domain; Region: SH3_3; pfam08239
438753005678	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
438753005679	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
438753005680	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
438753005681	CreA protein; Region: CreA; pfam05981
438753005682	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
438753005683	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
438753005684	active site
438753005685	HIGH motif; other site
438753005686	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
438753005687	KMSKS motif; other site
438753005688	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
438753005689	tRNA binding surface [nucleotide binding]; other site
438753005690	anticodon binding site; other site
438753005691	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
438753005692	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753005693	Coenzyme A binding pocket [chemical binding]; other site
438753005694	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
438753005695	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
438753005696	active site
438753005697	catalytic residues [active]
438753005698	metal binding site [ion binding]; metal-binding site
438753005699	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
438753005700	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
438753005701	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
438753005702	NAD binding site [chemical binding]; other site
438753005703	catalytic residues [active]
438753005704	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
438753005705	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
438753005706	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
438753005707	TOBE domain; Region: TOBE; cl01440
438753005708	TOBE domain; Region: TOBE; cl01440
438753005709	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
438753005710	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
438753005711	active site clefts [active]
438753005712	zinc binding site [ion binding]; other site
438753005713	dimer interface [polypeptide binding]; other site
438753005714	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
438753005715	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
438753005716	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
438753005717	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
438753005718	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
438753005719	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
438753005720	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
438753005721	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
438753005722	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
438753005723	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753005724	dimer interface [polypeptide binding]; other site
438753005725	conserved gate region; other site
438753005726	putative PBP binding loops; other site
438753005727	ABC-ATPase subunit interface; other site
438753005728	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
438753005729	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753005730	dimer interface [polypeptide binding]; other site
438753005731	conserved gate region; other site
438753005732	putative PBP binding loops; other site
438753005733	ABC-ATPase subunit interface; other site
438753005734	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
438753005735	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753005736	Walker A/P-loop; other site
438753005737	ATP binding site [chemical binding]; other site
438753005738	Q-loop/lid; other site
438753005739	ABC transporter signature motif; other site
438753005740	Walker B; other site
438753005741	D-loop; other site
438753005742	H-loop/switch region; other site
438753005743	TOBE domain; Region: TOBE_2; pfam08402
438753005744	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
438753005745	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
438753005746	hypothetical protein; Validated; Region: PRK06201
438753005747	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
438753005748	nitrilase; Region: PLN02798
438753005749	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
438753005750	putative active site [active]
438753005751	catalytic triad [active]
438753005752	dimer interface [polypeptide binding]; other site
438753005753	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753005754	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753005755	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
438753005756	dimerization interface [polypeptide binding]; other site
438753005757	putative hydrolase; Provisional; Region: PRK11460
438753005758	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
438753005759	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
438753005760	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
438753005761	enoyl-CoA hydratase; Provisional; Region: PRK06144
438753005762	substrate binding site [chemical binding]; other site
438753005763	oxyanion hole (OAH) forming residues; other site
438753005764	trimer interface [polypeptide binding]; other site
438753005765	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
438753005766	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971
438753005767	active site
438753005768	acyl-activating enzyme (AAE) consensus motif; other site
438753005769	putative CoA binding site [chemical binding]; other site
438753005770	AMP binding site [chemical binding]; other site
438753005771	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
438753005772	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
438753005773	substrate binding site [chemical binding]; other site
438753005774	hexamer interface [polypeptide binding]; other site
438753005775	metal binding site [ion binding]; metal-binding site
438753005776	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
438753005777	AMP binding site [chemical binding]; other site
438753005778	metal binding site [ion binding]; metal-binding site
438753005779	active site
438753005780	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
438753005781	homooctamer interface [polypeptide binding]; other site
438753005782	active site
438753005783	ATP-grasp domain; Region: ATP-grasp_4; cl17255
438753005784	Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232
438753005785	ATP-grasp domain; Region: ATP-grasp_4; cl17255
438753005786	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
438753005787	HIT family signature motif; other site
438753005788	catalytic residue [active]
438753005789	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
438753005790	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
438753005791	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
438753005792	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
438753005793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
438753005794	Uncharacterized conserved protein [Function unknown]; Region: COG2308
438753005795	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
438753005796	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
438753005797	putative MPT binding site; other site
438753005798	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
438753005799	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
438753005800	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753005801	Cytochrome C' Region: Cytochrom_C_2; pfam01322
438753005802	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
438753005803	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
438753005804	Ligand Binding Site [chemical binding]; other site
438753005805	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
438753005806	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
438753005807	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
438753005808	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
438753005809	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
438753005810	motif II; other site
438753005811	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
438753005812	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
438753005813	AsnC family; Region: AsnC_trans_reg; pfam01037
438753005814	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
438753005815	dimer interface [polypeptide binding]; other site
438753005816	substrate binding site [chemical binding]; other site
438753005817	ATP binding site [chemical binding]; other site
438753005818	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
438753005819	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753005820	non-specific DNA binding site [nucleotide binding]; other site
438753005821	salt bridge; other site
438753005822	sequence-specific DNA binding site [nucleotide binding]; other site
438753005823	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
438753005824	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
438753005825	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
438753005826	Flavodoxin; Region: Flavodoxin_1; pfam00258
438753005827	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
438753005828	FAD binding pocket [chemical binding]; other site
438753005829	FAD binding motif [chemical binding]; other site
438753005830	catalytic residues [active]
438753005831	NAD binding pocket [chemical binding]; other site
438753005832	phosphate binding motif [ion binding]; other site
438753005833	beta-alpha-beta structure motif; other site
438753005834	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
438753005835	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
438753005836	FAD binding pocket [chemical binding]; other site
438753005837	FAD binding motif [chemical binding]; other site
438753005838	phosphate binding motif [ion binding]; other site
438753005839	beta-alpha-beta structure motif; other site
438753005840	NAD binding pocket [chemical binding]; other site
438753005841	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
438753005842	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
438753005843	active site
438753005844	motif I; other site
438753005845	motif II; other site
438753005846	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
438753005847	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
438753005848	substrate binding site; other site
438753005849	tetramer interface; other site
438753005850	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
438753005851	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
438753005852	NADP binding site [chemical binding]; other site
438753005853	active site
438753005854	putative substrate binding site [chemical binding]; other site
438753005855	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
438753005856	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
438753005857	NAD binding site [chemical binding]; other site
438753005858	substrate binding site [chemical binding]; other site
438753005859	homodimer interface [polypeptide binding]; other site
438753005860	active site
438753005861	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
438753005862	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753005863	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753005864	substrate binding pocket [chemical binding]; other site
438753005865	membrane-bound complex binding site; other site
438753005866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753005867	dimer interface [polypeptide binding]; other site
438753005868	conserved gate region; other site
438753005869	ABC-ATPase subunit interface; other site
438753005870	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753005871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753005872	dimer interface [polypeptide binding]; other site
438753005873	conserved gate region; other site
438753005874	putative PBP binding loops; other site
438753005875	ABC-ATPase subunit interface; other site
438753005876	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753005877	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753005878	Walker A/P-loop; other site
438753005879	ATP binding site [chemical binding]; other site
438753005880	Q-loop/lid; other site
438753005881	ABC transporter signature motif; other site
438753005882	Walker B; other site
438753005883	D-loop; other site
438753005884	H-loop/switch region; other site
438753005885	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
438753005886	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
438753005887	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
438753005888	CoA-transferase family III; Region: CoA_transf_3; pfam02515
438753005889	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753005890	S-adenosylmethionine binding site [chemical binding]; other site
438753005891	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
438753005892	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753005893	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
438753005894	putative dimerization interface [polypeptide binding]; other site
438753005895	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
438753005896	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
438753005897	aminotransferase; Validated; Region: PRK09148
438753005898	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753005899	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753005900	homodimer interface [polypeptide binding]; other site
438753005901	catalytic residue [active]
438753005902	homoserine dehydrogenase; Provisional; Region: PRK06349
438753005903	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
438753005904	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
438753005905	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
438753005906	fructose 1,6-bisphosphatase II; Reviewed; Region: glpX; PRK09479
438753005907	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
438753005908	active site
438753005909	FAD binding domain; Region: FAD_binding_3; pfam01494
438753005910	hypothetical protein; Provisional; Region: PRK07236
438753005911	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
438753005912	DHH family; Region: DHH; pfam01368
438753005913	DHHA1 domain; Region: DHHA1; pfam02272
438753005914	DNA polymerase IV; Provisional; Region: PRK02794
438753005915	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
438753005916	active site
438753005917	DNA binding site [nucleotide binding]
438753005918	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
438753005919	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
438753005920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753005921	active site
438753005922	phosphorylation site [posttranslational modification]
438753005923	intermolecular recognition site; other site
438753005924	dimerization interface [polypeptide binding]; other site
438753005925	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
438753005926	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753005927	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753005928	putative substrate translocation pore; other site
438753005929	NUDIX domain; Region: NUDIX; pfam00293
438753005930	Protein of unknown function (DUF983); Region: DUF983; cl02211
438753005931	ribonuclease R; Region: RNase_R; TIGR02063
438753005932	RNB domain; Region: RNB; pfam00773
438753005933	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
438753005934	RNA binding site [nucleotide binding]; other site
438753005935	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753005936	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753005937	putative substrate translocation pore; other site
438753005938	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
438753005939	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
438753005940	active site
438753005941	interdomain interaction site; other site
438753005942	putative metal-binding site [ion binding]; other site
438753005943	nucleotide binding site [chemical binding]; other site
438753005944	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
438753005945	DNA binding groove [nucleotide binding]
438753005946	domain I; other site
438753005947	phosphate binding site [ion binding]; other site
438753005948	domain II; other site
438753005949	domain III; other site
438753005950	nucleotide binding site [chemical binding]; other site
438753005951	catalytic site [active]
438753005952	domain IV; other site
438753005953	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
438753005954	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
438753005955	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
438753005956	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
438753005957	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753005958	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753005959	Ion transport protein; Region: Ion_trans; pfam00520
438753005960	Ion channel; Region: Ion_trans_2; pfam07885
438753005961	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
438753005962	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
438753005963	ligand binding site [chemical binding]; other site
438753005964	flexible hinge region; other site
438753005965	isocitrate dehydrogenase; Validated; Region: PRK08299
438753005966	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
438753005967	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
438753005968	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
438753005969	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753005970	Walker A/P-loop; other site
438753005971	ATP binding site [chemical binding]; other site
438753005972	Q-loop/lid; other site
438753005973	ABC transporter signature motif; other site
438753005974	Walker B; other site
438753005975	D-loop; other site
438753005976	H-loop/switch region; other site
438753005977	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
438753005978	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753005979	Walker A/P-loop; other site
438753005980	ATP binding site [chemical binding]; other site
438753005981	Q-loop/lid; other site
438753005982	ABC transporter signature motif; other site
438753005983	Walker B; other site
438753005984	D-loop; other site
438753005985	H-loop/switch region; other site
438753005986	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753005987	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
438753005988	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753005989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753005990	dimer interface [polypeptide binding]; other site
438753005991	conserved gate region; other site
438753005992	putative PBP binding loops; other site
438753005993	ABC-ATPase subunit interface; other site
438753005994	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753005995	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
438753005996	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
438753005997	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
438753005998	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
438753005999	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753006000	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
438753006001	dimerization interface [polypeptide binding]; other site
438753006002	substrate binding pocket [chemical binding]; other site
438753006003	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
438753006004	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
438753006005	molybdopterin cofactor binding site [chemical binding]; other site
438753006006	substrate binding site [chemical binding]; other site
438753006007	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
438753006008	molybdopterin cofactor binding site; other site
438753006009	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
438753006010	CoA-transferase family III; Region: CoA_transf_3; pfam02515
438753006011	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
438753006012	putative active site [active]
438753006013	putative catalytic site [active]
438753006014	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
438753006015	Putative transcription activator [Transcription]; Region: TenA; COG0819
438753006016	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753006017	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753006018	DNA-binding site [nucleotide binding]; DNA binding site
438753006019	FCD domain; Region: FCD; pfam07729
438753006020	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
438753006021	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
438753006022	active site
438753006023	C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343
438753006024	active site
438753006025	metal binding site [ion binding]; metal-binding site
438753006026	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
438753006027	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
438753006028	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
438753006029	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
438753006030	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
438753006031	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
438753006032	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
438753006033	putative ligand binding site [chemical binding]; other site
438753006034	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753006035	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753006036	TM-ABC transporter signature motif; other site
438753006037	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753006038	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753006039	TM-ABC transporter signature motif; other site
438753006040	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753006041	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753006042	Walker A/P-loop; other site
438753006043	ATP binding site [chemical binding]; other site
438753006044	Q-loop/lid; other site
438753006045	ABC transporter signature motif; other site
438753006046	Walker B; other site
438753006047	D-loop; other site
438753006048	H-loop/switch region; other site
438753006049	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753006050	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753006051	Walker A/P-loop; other site
438753006052	ATP binding site [chemical binding]; other site
438753006053	Q-loop/lid; other site
438753006054	ABC transporter signature motif; other site
438753006055	Walker B; other site
438753006056	D-loop; other site
438753006057	H-loop/switch region; other site
438753006058	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
438753006059	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
438753006060	putative NAD(P) binding site [chemical binding]; other site
438753006061	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
438753006062	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
438753006063	active site
438753006064	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
438753006065	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
438753006066	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
438753006067	Uncharacterized conserved protein [Function unknown]; Region: COG1359
438753006068	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
438753006069	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
438753006070	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
438753006071	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
438753006072	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753006073	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
438753006074	dimerization interface [polypeptide binding]; other site
438753006075	substrate binding pocket [chemical binding]; other site
438753006076	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
438753006077	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
438753006078	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
438753006079	DctM-like transporters; Region: DctM; pfam06808
438753006080	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
438753006081	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
438753006082	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
438753006083	malate:quinone oxidoreductase; Validated; Region: PRK05257
438753006084	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
438753006085	Cupin domain; Region: Cupin_2; pfam07883
438753006086	fumarate hydratase; Reviewed; Region: fumC; PRK00485
438753006087	Class II fumarases; Region: Fumarase_classII; cd01362
438753006088	active site
438753006089	tetramer interface [polypeptide binding]; other site
438753006090	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
438753006091	benzoate transport; Region: 2A0115; TIGR00895
438753006092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753006093	putative substrate translocation pore; other site
438753006094	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753006095	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
438753006096	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
438753006097	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
438753006098	putative active site [active]
438753006099	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753006100	NAD(P) binding site [chemical binding]; other site
438753006101	active site
438753006102	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
438753006103	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
438753006104	E3 interaction surface; other site
438753006105	lipoyl attachment site [posttranslational modification]; other site
438753006106	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
438753006107	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
438753006108	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
438753006109	alpha subunit interface [polypeptide binding]; other site
438753006110	TPP binding site [chemical binding]; other site
438753006111	heterodimer interface [polypeptide binding]; other site
438753006112	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
438753006113	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
438753006114	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
438753006115	tetramer interface [polypeptide binding]; other site
438753006116	TPP-binding site [chemical binding]; other site
438753006117	heterodimer interface [polypeptide binding]; other site
438753006118	phosphorylation loop region [posttranslational modification]
438753006119	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
438753006120	ATP-NAD kinase; Region: NAD_kinase; pfam01513
438753006121	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
438753006122	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753006123	Walker A motif; other site
438753006124	ATP binding site [chemical binding]; other site
438753006125	Walker B motif; other site
438753006126	arginine finger; other site
438753006127	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
438753006128	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
438753006129	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
438753006130	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
438753006131	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
438753006132	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
438753006133	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
438753006134	N-terminal plug; other site
438753006135	ligand-binding site [chemical binding]; other site
438753006136	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753006137	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753006138	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753006139	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753006140	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753006141	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753006142	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753006143	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753006144	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753006145	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753006146	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753006147	Autotransporter beta-domain; Region: Autotransporter; pfam03797
438753006148	Protein of unknown function (DUF779); Region: DUF779; cl01432
438753006149	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
438753006150	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
438753006151	NAD(P) binding site [chemical binding]; other site
438753006152	catalytic residues [active]
438753006153	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
438753006154	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
438753006155	Cupin domain; Region: Cupin_2; pfam07883
438753006156	haemagglutination activity domain; Region: Haemagg_act; smart00912
438753006157	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
438753006158	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
438753006159	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
438753006160	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
438753006161	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
438753006162	tetramer interface [polypeptide binding]; other site
438753006163	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753006164	catalytic residue [active]
438753006165	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753006166	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753006167	Walker A/P-loop; other site
438753006168	ATP binding site [chemical binding]; other site
438753006169	Q-loop/lid; other site
438753006170	ABC transporter signature motif; other site
438753006171	Walker B; other site
438753006172	D-loop; other site
438753006173	H-loop/switch region; other site
438753006174	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006175	dimer interface [polypeptide binding]; other site
438753006176	conserved gate region; other site
438753006177	putative PBP binding loops; other site
438753006178	ABC-ATPase subunit interface; other site
438753006179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006180	dimer interface [polypeptide binding]; other site
438753006181	conserved gate region; other site
438753006182	putative PBP binding loops; other site
438753006183	ABC-ATPase subunit interface; other site
438753006184	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
438753006185	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753006186	substrate binding pocket [chemical binding]; other site
438753006187	membrane-bound complex binding site; other site
438753006188	hinge residues; other site
438753006189	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
438753006190	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753006191	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
438753006192	putative dimerization interface [polypeptide binding]; other site
438753006193	HTH-like domain; Region: HTH_21; pfam13276
438753006194	Integrase core domain; Region: rve; pfam00665
438753006195	Integrase core domain; Region: rve_3; pfam13683
438753006196	Transposase; Region: HTH_Tnp_1; pfam01527
438753006197	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753006198	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
438753006199	dimer interface [polypeptide binding]; other site
438753006200	active site
438753006201	metal binding site [ion binding]; metal-binding site
438753006202	glutathione binding site [chemical binding]; other site
438753006203	NAD-dependent deacetylase; Provisional; Region: PRK00481
438753006204	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
438753006205	NAD+ binding site [chemical binding]; other site
438753006206	substrate binding site [chemical binding]; other site
438753006207	Zn binding site [ion binding]; other site
438753006208	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
438753006209	DNA-binding site [nucleotide binding]; DNA binding site
438753006210	RNA-binding motif; other site
438753006211	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
438753006212	DNA-binding site [nucleotide binding]; DNA binding site
438753006213	RNA-binding motif; other site
438753006214	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
438753006215	PAS fold; Region: PAS_4; pfam08448
438753006216	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
438753006217	HWE histidine kinase; Region: HWE_HK; pfam07536
438753006218	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
438753006219	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
438753006220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753006221	active site
438753006222	phosphorylation site [posttranslational modification]
438753006223	intermolecular recognition site; other site
438753006224	dimerization interface [polypeptide binding]; other site
438753006225	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753006226	DNA binding site [nucleotide binding]
438753006227	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
438753006228	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753006229	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753006230	dimer interface [polypeptide binding]; other site
438753006231	phosphorylation site [posttranslational modification]
438753006232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753006233	ATP binding site [chemical binding]; other site
438753006234	Mg2+ binding site [ion binding]; other site
438753006235	G-X-G motif; other site
438753006236	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753006237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
438753006238	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753006239	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753006240	Walker A/P-loop; other site
438753006241	ATP binding site [chemical binding]; other site
438753006242	Q-loop/lid; other site
438753006243	ABC transporter signature motif; other site
438753006244	Walker B; other site
438753006245	D-loop; other site
438753006246	H-loop/switch region; other site
438753006247	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
438753006248	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
438753006249	cytosine deaminase; Provisional; Region: PRK05985
438753006250	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
438753006251	active site
438753006252	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
438753006253	homotrimer interaction site [polypeptide binding]; other site
438753006254	putative active site [active]
438753006255	allantoate amidohydrolase; Reviewed; Region: PRK12893
438753006256	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
438753006257	active site
438753006258	metal binding site [ion binding]; metal-binding site
438753006259	dimer interface [polypeptide binding]; other site
438753006260	metabolite-proton symporter; Region: 2A0106; TIGR00883
438753006261	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753006262	putative substrate translocation pore; other site
438753006263	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753006264	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753006265	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
438753006266	dimerization interface [polypeptide binding]; other site
438753006267	NMT1-like family; Region: NMT1_2; pfam13379
438753006268	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
438753006269	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753006270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
438753006271	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753006272	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753006273	Walker A/P-loop; other site
438753006274	ATP binding site [chemical binding]; other site
438753006275	Q-loop/lid; other site
438753006276	ABC transporter signature motif; other site
438753006277	Walker B; other site
438753006278	D-loop; other site
438753006279	H-loop/switch region; other site
438753006280	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753006281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753006282	active site
438753006283	phosphorylation site [posttranslational modification]
438753006284	intermolecular recognition site; other site
438753006285	dimerization interface [polypeptide binding]; other site
438753006286	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753006287	DNA binding site [nucleotide binding]
438753006288	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
438753006289	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753006290	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753006291	dimer interface [polypeptide binding]; other site
438753006292	phosphorylation site [posttranslational modification]
438753006293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753006294	ATP binding site [chemical binding]; other site
438753006295	Mg2+ binding site [ion binding]; other site
438753006296	G-X-G motif; other site
438753006297	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
438753006298	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
438753006299	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753006300	Walker A/P-loop; other site
438753006301	ATP binding site [chemical binding]; other site
438753006302	Q-loop/lid; other site
438753006303	ABC transporter signature motif; other site
438753006304	Walker B; other site
438753006305	D-loop; other site
438753006306	H-loop/switch region; other site
438753006307	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753006308	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753006309	Walker A/P-loop; other site
438753006310	ATP binding site [chemical binding]; other site
438753006311	Q-loop/lid; other site
438753006312	ABC transporter signature motif; other site
438753006313	Walker B; other site
438753006314	D-loop; other site
438753006315	H-loop/switch region; other site
438753006316	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753006317	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
438753006318	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
438753006319	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006320	dimer interface [polypeptide binding]; other site
438753006321	conserved gate region; other site
438753006322	putative PBP binding loops; other site
438753006323	ABC-ATPase subunit interface; other site
438753006324	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753006325	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006326	dimer interface [polypeptide binding]; other site
438753006327	conserved gate region; other site
438753006328	putative PBP binding loops; other site
438753006329	ABC-ATPase subunit interface; other site
438753006330	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
438753006331	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
438753006332	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
438753006333	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
438753006334	short chain dehydrogenase; Provisional; Region: PRK06138
438753006335	classical (c) SDRs; Region: SDR_c; cd05233
438753006336	NAD(P) binding site [chemical binding]; other site
438753006337	active site
438753006338	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
438753006339	extended (e) SDRs; Region: SDR_e; cd08946
438753006340	NAD(P) binding site [chemical binding]; other site
438753006341	active site
438753006342	substrate binding site [chemical binding]; other site
438753006343	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
438753006344	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
438753006345	homodimer interface [polypeptide binding]; other site
438753006346	substrate-cofactor binding pocket; other site
438753006347	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753006348	catalytic residue [active]
438753006349	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753006350	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753006351	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753006352	dimerization interface [polypeptide binding]; other site
438753006353	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
438753006354	dihydropyrimidinase; Provisional; Region: PRK13404
438753006355	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
438753006356	tetramer interface [polypeptide binding]; other site
438753006357	active site
438753006358	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753006359	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753006360	DNA-binding site [nucleotide binding]; DNA binding site
438753006361	FCD domain; Region: FCD; pfam07729
438753006362	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
438753006363	active site
438753006364	homotetramer interface [polypeptide binding]; other site
438753006365	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
438753006366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006367	dimer interface [polypeptide binding]; other site
438753006368	conserved gate region; other site
438753006369	putative PBP binding loops; other site
438753006370	ABC-ATPase subunit interface; other site
438753006371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006372	dimer interface [polypeptide binding]; other site
438753006373	conserved gate region; other site
438753006374	putative PBP binding loops; other site
438753006375	ABC-ATPase subunit interface; other site
438753006376	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
438753006377	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
438753006378	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
438753006379	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753006380	Walker A/P-loop; other site
438753006381	ATP binding site [chemical binding]; other site
438753006382	Q-loop/lid; other site
438753006383	ABC transporter signature motif; other site
438753006384	Walker B; other site
438753006385	D-loop; other site
438753006386	H-loop/switch region; other site
438753006387	TOBE domain; Region: TOBE_2; pfam08402
438753006388	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753006389	Amidase; Region: Amidase; cl11426
438753006390	Transcriptional regulators [Transcription]; Region: FadR; COG2186
438753006391	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753006392	DNA-binding site [nucleotide binding]; DNA binding site
438753006393	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
438753006394	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
438753006395	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
438753006396	active site
438753006397	NAD binding site [chemical binding]; other site
438753006398	metal binding site [ion binding]; metal-binding site
438753006399	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
438753006400	BNR repeat-like domain; Region: BNR_2; pfam13088
438753006401	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753006402	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753006403	Walker A/P-loop; other site
438753006404	ATP binding site [chemical binding]; other site
438753006405	Q-loop/lid; other site
438753006406	ABC transporter signature motif; other site
438753006407	Walker B; other site
438753006408	D-loop; other site
438753006409	H-loop/switch region; other site
438753006410	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753006411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006412	dimer interface [polypeptide binding]; other site
438753006413	conserved gate region; other site
438753006414	putative PBP binding loops; other site
438753006415	ABC-ATPase subunit interface; other site
438753006416	NMT1/THI5 like; Region: NMT1; pfam09084
438753006417	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
438753006418	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
438753006419	classical (c) SDRs; Region: SDR_c; cd05233
438753006420	NAD(P) binding site [chemical binding]; other site
438753006421	active site
438753006422	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
438753006423	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
438753006424	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753006425	Walker A/P-loop; other site
438753006426	ATP binding site [chemical binding]; other site
438753006427	Q-loop/lid; other site
438753006428	ABC transporter signature motif; other site
438753006429	Walker B; other site
438753006430	D-loop; other site
438753006431	H-loop/switch region; other site
438753006432	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753006433	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
438753006434	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753006435	Walker A/P-loop; other site
438753006436	ATP binding site [chemical binding]; other site
438753006437	Q-loop/lid; other site
438753006438	ABC transporter signature motif; other site
438753006439	Walker B; other site
438753006440	D-loop; other site
438753006441	H-loop/switch region; other site
438753006442	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753006443	D-ala-D-ala transporter subunit; Provisional; Region: PRK09881
438753006444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006445	dimer interface [polypeptide binding]; other site
438753006446	conserved gate region; other site
438753006447	putative PBP binding loops; other site
438753006448	ABC-ATPase subunit interface; other site
438753006449	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753006450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006451	dimer interface [polypeptide binding]; other site
438753006452	conserved gate region; other site
438753006453	putative PBP binding loops; other site
438753006454	ABC-ATPase subunit interface; other site
438753006455	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753006456	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
438753006457	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
438753006458	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
438753006459	metal binding site [ion binding]; metal-binding site
438753006460	putative dimer interface [polypeptide binding]; other site
438753006461	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
438753006462	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
438753006463	active site
438753006464	catalytic site [active]
438753006465	tetramer interface [polypeptide binding]; other site
438753006466	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
438753006467	Domain of unknown function (DUF1850); Region: DUF1850; cl01950
438753006468	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006469	dimer interface [polypeptide binding]; other site
438753006470	conserved gate region; other site
438753006471	putative PBP binding loops; other site
438753006472	ABC-ATPase subunit interface; other site
438753006473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006474	putative PBP binding loops; other site
438753006475	ABC-ATPase subunit interface; other site
438753006476	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
438753006477	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753006478	Walker A/P-loop; other site
438753006479	ATP binding site [chemical binding]; other site
438753006480	Q-loop/lid; other site
438753006481	ABC transporter signature motif; other site
438753006482	Walker B; other site
438753006483	D-loop; other site
438753006484	H-loop/switch region; other site
438753006485	TOBE domain; Region: TOBE_2; pfam08402
438753006486	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
438753006487	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
438753006488	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753006489	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753006490	DNA-binding site [nucleotide binding]; DNA binding site
438753006491	FCD domain; Region: FCD; pfam07729
438753006492	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
438753006493	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753006494	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
438753006495	active site
438753006496	catalytic residues [active]
438753006497	metal binding site [ion binding]; metal-binding site
438753006498	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753006499	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753006500	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
438753006501	putative effector binding pocket; other site
438753006502	putative dimerization interface [polypeptide binding]; other site
438753006503	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
438753006504	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
438753006505	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
438753006506	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
438753006507	NADP binding site [chemical binding]; other site
438753006508	dimer interface [polypeptide binding]; other site
438753006509	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
438753006510	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
438753006511	Zn2+ binding site [ion binding]; other site
438753006512	Mg2+ binding site [ion binding]; other site
438753006513	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
438753006514	synthetase active site [active]
438753006515	NTP binding site [chemical binding]; other site
438753006516	metal binding site [ion binding]; metal-binding site
438753006517	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
438753006518	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
438753006519	pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265
438753006520	active site
438753006521	hydrophilic channel; other site
438753006522	dimerization interface [polypeptide binding]; other site
438753006523	catalytic residues [active]
438753006524	active site lid [active]
438753006525	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
438753006526	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
438753006527	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
438753006528	Catalytic site [active]
438753006529	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
438753006530	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
438753006531	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
438753006532	dimerization interface [polypeptide binding]; other site
438753006533	active site
438753006534	metal binding site [ion binding]; metal-binding site
438753006535	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
438753006536	GTPase Era; Reviewed; Region: era; PRK00089
438753006537	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
438753006538	G1 box; other site
438753006539	GTP/Mg2+ binding site [chemical binding]; other site
438753006540	Switch I region; other site
438753006541	G2 box; other site
438753006542	Switch II region; other site
438753006543	G3 box; other site
438753006544	G4 box; other site
438753006545	G5 box; other site
438753006546	KH domain; Region: KH_2; pfam07650
438753006547	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
438753006548	Recombination protein O N terminal; Region: RecO_N; pfam11967
438753006549	Recombination protein O C terminal; Region: RecO_C; pfam02565
438753006550	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
438753006551	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
438753006552	CAP-like domain; other site
438753006553	active site
438753006554	primary dimer interface [polypeptide binding]; other site
438753006555	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
438753006556	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
438753006557	Cl- selectivity filter; other site
438753006558	Cl- binding residues [ion binding]; other site
438753006559	pore gating glutamate residue; other site
438753006560	dimer interface [polypeptide binding]; other site
438753006561	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
438753006562	hypothetical protein; Provisional; Region: PRK06486
438753006563	intersubunit interface [polypeptide binding]; other site
438753006564	active site
438753006565	Zn2+ binding site [ion binding]; other site
438753006566	ornithine cyclodeaminase; Validated; Region: PRK06141
438753006567	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
438753006568	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
438753006569	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753006570	Walker A/P-loop; other site
438753006571	ATP binding site [chemical binding]; other site
438753006572	Q-loop/lid; other site
438753006573	ABC transporter signature motif; other site
438753006574	Walker B; other site
438753006575	D-loop; other site
438753006576	H-loop/switch region; other site
438753006577	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
438753006578	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
438753006579	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753006580	Walker A/P-loop; other site
438753006581	ATP binding site [chemical binding]; other site
438753006582	Q-loop/lid; other site
438753006583	ABC transporter signature motif; other site
438753006584	Walker B; other site
438753006585	D-loop; other site
438753006586	H-loop/switch region; other site
438753006587	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
438753006588	D-ala-D-ala transporter subunit; Provisional; Region: PRK09881
438753006589	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006590	dimer interface [polypeptide binding]; other site
438753006591	conserved gate region; other site
438753006592	putative PBP binding loops; other site
438753006593	ABC-ATPase subunit interface; other site
438753006594	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753006595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006596	dimer interface [polypeptide binding]; other site
438753006597	conserved gate region; other site
438753006598	ABC-ATPase subunit interface; other site
438753006599	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753006600	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
438753006601	dihydroorotase; Provisional; Region: PRK09237
438753006602	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753006603	active site
438753006604	N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569
438753006605	Predicted amidohydrolase [General function prediction only]; Region: COG0388
438753006606	tetramer interface [polypeptide binding]; other site
438753006607	active site
438753006608	catalytic triad [active]
438753006609	dimer interface [polypeptide binding]; other site
438753006610	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
438753006611	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
438753006612	tetramer interface [polypeptide binding]; other site
438753006613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753006614	catalytic residue [active]
438753006615	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
438753006616	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753006617	non-specific DNA binding site [nucleotide binding]; other site
438753006618	salt bridge; other site
438753006619	sequence-specific DNA binding site [nucleotide binding]; other site
438753006620	Cupin domain; Region: Cupin_2; pfam07883
438753006621	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753006622	Amidase; Region: Amidase; pfam01425
438753006623	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753006624	D-galactonate transporter; Region: 2A0114; TIGR00893
438753006625	putative substrate translocation pore; other site
438753006626	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
438753006627	homotrimer interaction site [polypeptide binding]; other site
438753006628	putative active site [active]
438753006629	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
438753006630	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
438753006631	hydroxyglutarate oxidase; Provisional; Region: PRK11728
438753006632	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
438753006633	hydroxyglutarate oxidase; Provisional; Region: PRK11728
438753006634	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
438753006635	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753006636	putative DNA binding site [nucleotide binding]; other site
438753006637	putative Zn2+ binding site [ion binding]; other site
438753006638	AsnC family; Region: AsnC_trans_reg; pfam01037
438753006639	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
438753006640	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753006641	Walker A/P-loop; other site
438753006642	ATP binding site [chemical binding]; other site
438753006643	Q-loop/lid; other site
438753006644	ABC transporter signature motif; other site
438753006645	Walker B; other site
438753006646	D-loop; other site
438753006647	H-loop/switch region; other site
438753006648	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753006649	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753006650	Walker A/P-loop; other site
438753006651	ATP binding site [chemical binding]; other site
438753006652	Q-loop/lid; other site
438753006653	ABC transporter signature motif; other site
438753006654	Walker B; other site
438753006655	D-loop; other site
438753006656	H-loop/switch region; other site
438753006657	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753006658	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
438753006659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006660	dimer interface [polypeptide binding]; other site
438753006661	conserved gate region; other site
438753006662	ABC-ATPase subunit interface; other site
438753006663	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753006664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006665	dimer interface [polypeptide binding]; other site
438753006666	conserved gate region; other site
438753006667	putative PBP binding loops; other site
438753006668	ABC-ATPase subunit interface; other site
438753006669	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753006670	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
438753006671	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
438753006672	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
438753006673	hypothetical protein; Provisional; Region: PRK05965
438753006674	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
438753006675	inhibitor-cofactor binding pocket; inhibition site
438753006676	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753006677	catalytic residue [active]
438753006678	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
438753006679	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
438753006680	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
438753006681	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
438753006682	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
438753006683	succinic semialdehyde dehydrogenase; Region: PLN02278
438753006684	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
438753006685	tetramerization interface [polypeptide binding]; other site
438753006686	NAD(P) binding site [chemical binding]; other site
438753006687	catalytic residues [active]
438753006688	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
438753006689	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
438753006690	NAD(P) binding site [chemical binding]; other site
438753006691	catalytic residues [active]
438753006692	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
438753006693	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
438753006694	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
438753006695	putative ligand binding site [chemical binding]; other site
438753006696	NAD binding site [chemical binding]; other site
438753006697	dimerization interface [polypeptide binding]; other site
438753006698	catalytic site [active]
438753006699	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
438753006700	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
438753006701	heme binding pocket [chemical binding]; other site
438753006702	heme ligand [chemical binding]; other site
438753006703	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753006704	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753006705	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753006706	dimerization interface [polypeptide binding]; other site
438753006707	putative amidase; Provisional; Region: PRK06169
438753006708	Amidase; Region: Amidase; cl11426
438753006709	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753006710	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753006711	DNA-binding site [nucleotide binding]; DNA binding site
438753006712	FCD domain; Region: FCD; pfam07729
438753006713	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
438753006714	intersubunit interface [polypeptide binding]; other site
438753006715	active site
438753006716	Zn2+ binding site [ion binding]; other site
438753006717	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753006718	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
438753006719	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753006720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006721	dimer interface [polypeptide binding]; other site
438753006722	conserved gate region; other site
438753006723	putative PBP binding loops; other site
438753006724	ABC-ATPase subunit interface; other site
438753006725	dipeptide transporter; Provisional; Region: PRK10913
438753006726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006727	dimer interface [polypeptide binding]; other site
438753006728	conserved gate region; other site
438753006729	putative PBP binding loops; other site
438753006730	ABC-ATPase subunit interface; other site
438753006731	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
438753006732	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753006733	Walker A/P-loop; other site
438753006734	ATP binding site [chemical binding]; other site
438753006735	Q-loop/lid; other site
438753006736	ABC transporter signature motif; other site
438753006737	Walker B; other site
438753006738	D-loop; other site
438753006739	H-loop/switch region; other site
438753006740	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753006741	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753006742	Walker A/P-loop; other site
438753006743	ATP binding site [chemical binding]; other site
438753006744	Q-loop/lid; other site
438753006745	ABC transporter signature motif; other site
438753006746	Walker B; other site
438753006747	D-loop; other site
438753006748	H-loop/switch region; other site
438753006749	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753006750	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
438753006751	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
438753006752	active site
438753006753	Zn binding site [ion binding]; other site
438753006754	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
438753006755	classical (c) SDRs; Region: SDR_c; cd05233
438753006756	NAD(P) binding site [chemical binding]; other site
438753006757	active site
438753006758	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753006759	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753006760	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
438753006761	putative effector binding pocket; other site
438753006762	dimerization interface [polypeptide binding]; other site
438753006763	Predicted membrane protein [Function unknown]; Region: COG2259
438753006764	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
438753006765	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
438753006766	putative metal binding site [ion binding]; other site
438753006767	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
438753006768	active site
438753006769	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
438753006770	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
438753006771	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
438753006772	putative dimer interface [polypeptide binding]; other site
438753006773	N-terminal domain interface [polypeptide binding]; other site
438753006774	putative substrate binding pocket (H-site) [chemical binding]; other site
438753006775	Fusaric acid resistance protein family; Region: FUSC; pfam04632
438753006776	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
438753006777	NMT1/THI5 like; Region: NMT1; pfam09084
438753006778	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753006779	substrate binding pocket [chemical binding]; other site
438753006780	membrane-bound complex binding site; other site
438753006781	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753006782	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006783	dimer interface [polypeptide binding]; other site
438753006784	conserved gate region; other site
438753006785	putative PBP binding loops; other site
438753006786	ABC-ATPase subunit interface; other site
438753006787	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753006788	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753006789	Walker A/P-loop; other site
438753006790	ATP binding site [chemical binding]; other site
438753006791	Q-loop/lid; other site
438753006792	ABC transporter signature motif; other site
438753006793	Walker B; other site
438753006794	D-loop; other site
438753006795	H-loop/switch region; other site
438753006796	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
438753006797	Phosphopantetheine attachment site; Region: PP-binding; cl09936
438753006798	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
438753006799	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753006800	NAD(P) binding site [chemical binding]; other site
438753006801	active site
438753006802	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
438753006803	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
438753006804	active site
438753006805	CoA binding site [chemical binding]; other site
438753006806	AMP binding site [chemical binding]; other site
438753006807	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
438753006808	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
438753006809	NAD(P) binding site [chemical binding]; other site
438753006810	catalytic residues [active]
438753006811	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
438753006812	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
438753006813	active site
438753006814	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
438753006815	dimer interface [polypeptide binding]; other site
438753006816	substrate binding site [chemical binding]; other site
438753006817	catalytic residues [active]
438753006818	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
438753006819	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
438753006820	hydroxyglutarate oxidase; Provisional; Region: PRK11728
438753006821	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
438753006822	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753006823	putative DNA binding site [nucleotide binding]; other site
438753006824	putative Zn2+ binding site [ion binding]; other site
438753006825	AsnC family; Region: AsnC_trans_reg; pfam01037
438753006826	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
438753006827	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
438753006828	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
438753006829	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753006830	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753006831	Walker A/P-loop; other site
438753006832	ATP binding site [chemical binding]; other site
438753006833	Q-loop/lid; other site
438753006834	ABC transporter signature motif; other site
438753006835	Walker B; other site
438753006836	D-loop; other site
438753006837	H-loop/switch region; other site
438753006838	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753006839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006840	dimer interface [polypeptide binding]; other site
438753006841	conserved gate region; other site
438753006842	putative PBP binding loops; other site
438753006843	ABC-ATPase subunit interface; other site
438753006844	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
438753006845	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753006846	substrate binding pocket [chemical binding]; other site
438753006847	membrane-bound complex binding site; other site
438753006848	hinge residues; other site
438753006849	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
438753006850	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753006851	non-specific DNA binding site [nucleotide binding]; other site
438753006852	salt bridge; other site
438753006853	sequence-specific DNA binding site [nucleotide binding]; other site
438753006854	Cupin domain; Region: Cupin_2; pfam07883
438753006855	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
438753006856	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
438753006857	metal binding site [ion binding]; metal-binding site
438753006858	dimer interface [polypeptide binding]; other site
438753006859	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
438753006860	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
438753006861	metal binding site [ion binding]; metal-binding site
438753006862	putative dimer interface [polypeptide binding]; other site
438753006863	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
438753006864	Uncharacterized conserved protein [Function unknown]; Region: COG5476
438753006865	MlrC C-terminus; Region: MlrC_C; pfam07171
438753006866	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
438753006867	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753006868	Walker A/P-loop; other site
438753006869	ATP binding site [chemical binding]; other site
438753006870	Q-loop/lid; other site
438753006871	ABC transporter signature motif; other site
438753006872	Walker B; other site
438753006873	D-loop; other site
438753006874	H-loop/switch region; other site
438753006875	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753006876	Walker A/P-loop; other site
438753006877	ATP binding site [chemical binding]; other site
438753006878	Q-loop/lid; other site
438753006879	ABC transporter signature motif; other site
438753006880	Walker B; other site
438753006881	D-loop; other site
438753006882	H-loop/switch region; other site
438753006883	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753006884	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
438753006885	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006886	dimer interface [polypeptide binding]; other site
438753006887	conserved gate region; other site
438753006888	putative PBP binding loops; other site
438753006889	ABC-ATPase subunit interface; other site
438753006890	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753006891	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006892	dimer interface [polypeptide binding]; other site
438753006893	conserved gate region; other site
438753006894	putative PBP binding loops; other site
438753006895	ABC-ATPase subunit interface; other site
438753006896	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753006897	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
438753006898	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
438753006899	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
438753006900	Predicted transporter component [General function prediction only]; Region: COG2391
438753006901	Sulphur transport; Region: Sulf_transp; pfam04143
438753006902	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
438753006903	Predicted transporter component [General function prediction only]; Region: COG2391
438753006904	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
438753006905	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753006906	dimerization interface [polypeptide binding]; other site
438753006907	putative DNA binding site [nucleotide binding]; other site
438753006908	putative Zn2+ binding site [ion binding]; other site
438753006909	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
438753006910	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753006911	putative substrate translocation pore; other site
438753006912	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
438753006913	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
438753006914	FMN binding site [chemical binding]; other site
438753006915	substrate binding site [chemical binding]; other site
438753006916	putative catalytic residue [active]
438753006917	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
438753006918	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
438753006919	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
438753006920	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
438753006921	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
438753006922	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
438753006923	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
438753006924	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
438753006925	dimer interface [polypeptide binding]; other site
438753006926	conserved gate region; other site
438753006927	putative PBP binding loops; other site
438753006928	ABC-ATPase subunit interface; other site
438753006929	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
438753006930	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753006931	Walker A/P-loop; other site
438753006932	ATP binding site [chemical binding]; other site
438753006933	Q-loop/lid; other site
438753006934	ABC transporter signature motif; other site
438753006935	Walker B; other site
438753006936	D-loop; other site
438753006937	H-loop/switch region; other site
438753006938	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
438753006939	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
438753006940	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753006941	dimer interface [polypeptide binding]; other site
438753006942	conserved gate region; other site
438753006943	putative PBP binding loops; other site
438753006944	ABC-ATPase subunit interface; other site
438753006945	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
438753006946	active site
438753006947	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
438753006948	Autotransporter beta-domain; Region: Autotransporter; pfam03797
438753006949	metabolite-proton symporter; Region: 2A0106; TIGR00883
438753006950	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
438753006951	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
438753006952	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
438753006953	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
438753006954	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
438753006955	D-pathway; other site
438753006956	Putative ubiquinol binding site [chemical binding]; other site
438753006957	Low-spin heme (heme b) binding site [chemical binding]; other site
438753006958	Putative water exit pathway; other site
438753006959	Binuclear center (heme o3/CuB) [ion binding]; other site
438753006960	K-pathway; other site
438753006961	Putative proton exit pathway; other site
438753006962	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
438753006963	Subunit I/III interface [polypeptide binding]; other site
438753006964	Subunit III/IV interface [polypeptide binding]; other site
438753006965	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
438753006966	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
438753006967	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753006968	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
438753006969	dimer interface [polypeptide binding]; other site
438753006970	phosphorylation site [posttranslational modification]
438753006971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753006972	ATP binding site [chemical binding]; other site
438753006973	Mg2+ binding site [ion binding]; other site
438753006974	G-X-G motif; other site
438753006975	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
438753006976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753006977	active site
438753006978	phosphorylation site [posttranslational modification]
438753006979	intermolecular recognition site; other site
438753006980	dimerization interface [polypeptide binding]; other site
438753006981	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
438753006982	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
438753006983	isopropylmalate isomerase large subunit; Provisional; Region: PRK12466
438753006984	substrate binding site [chemical binding]; other site
438753006985	ligand binding site [chemical binding]; other site
438753006986	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
438753006987	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
438753006988	substrate binding site [chemical binding]; other site
438753006989	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
438753006990	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753006991	DNA-binding site [nucleotide binding]; DNA binding site
438753006992	UTRA domain; Region: UTRA; pfam07702
438753006993	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753006994	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340
438753006995	putative ligand binding site [chemical binding]; other site
438753006996	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753006997	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753006998	TM-ABC transporter signature motif; other site
438753006999	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753007000	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753007001	TM-ABC transporter signature motif; other site
438753007002	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753007003	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753007004	Walker A/P-loop; other site
438753007005	ATP binding site [chemical binding]; other site
438753007006	Q-loop/lid; other site
438753007007	ABC transporter signature motif; other site
438753007008	Walker B; other site
438753007009	D-loop; other site
438753007010	H-loop/switch region; other site
438753007011	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753007012	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753007013	Walker A/P-loop; other site
438753007014	ATP binding site [chemical binding]; other site
438753007015	Q-loop/lid; other site
438753007016	ABC transporter signature motif; other site
438753007017	Walker B; other site
438753007018	D-loop; other site
438753007019	H-loop/switch region; other site
438753007020	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
438753007021	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
438753007022	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
438753007023	tetramer interface [polypeptide binding]; other site
438753007024	active site
438753007025	Mg2+/Mn2+ binding site [ion binding]; other site
438753007026	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
438753007027	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
438753007028	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
438753007029	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
438753007030	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
438753007031	Isochorismatase family; Region: Isochorismatase; pfam00857
438753007032	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
438753007033	catalytic triad [active]
438753007034	conserved cis-peptide bond; other site
438753007035	hypothetical protein; Provisional; Region: PRK06185
438753007036	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
438753007037	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
438753007038	Isochorismatase family; Region: Isochorismatase; pfam00857
438753007039	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
438753007040	catalytic triad [active]
438753007041	dimer interface [polypeptide binding]; other site
438753007042	conserved cis-peptide bond; other site
438753007043	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
438753007044	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
438753007045	DDE superfamily endonuclease; Region: DDE_3; pfam13358
438753007046	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
438753007047	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
438753007048	non-specific DNA binding site [nucleotide binding]; other site
438753007049	salt bridge; other site
438753007050	sequence-specific DNA binding site [nucleotide binding]; other site
438753007051	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
438753007052	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
438753007053	Integrase core domain; Region: rve; pfam00665
438753007054	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
438753007055	AAA domain; Region: AAA_22; pfam13401
438753007056	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
438753007057	DnaA box-binding interface [nucleotide binding]; other site
438753007058	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
438753007059	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
438753007060	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
438753007061	catalytic residues [active]
438753007062	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
438753007063	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
438753007064	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
438753007065	Terminase-like family; Region: Terminase_6; pfam03237
438753007066	Protein of unknown function (DUF935); Region: DUF935; pfam06074
438753007067	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
438753007068	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
438753007069	sporadically distributed protein, TIGR04141 family; Region: TIGR04141
438753007070	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
438753007071	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
438753007072	Protein of unknown function (DUF1320); Region: DUF1320; cl01818
438753007073	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
438753007074	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
438753007075	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
438753007076	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
438753007077	Baseplate J-like protein; Region: Baseplate_J; cl01294
438753007078	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
438753007079	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
438753007080	Phage tail tube protein FII; Region: Phage_tube; cl01390
438753007081	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
438753007082	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
438753007083	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
438753007084	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
438753007085	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
438753007086	DNA methylase; Region: N6_N4_Mtase; cl17433
438753007087	DNA methylase; Region: N6_N4_Mtase; pfam01555
438753007088	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
438753007089	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
438753007090	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
438753007091	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
438753007092	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
438753007093	thymidylate kinase; Validated; Region: tmk; PRK00698
438753007094	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
438753007095	TMP-binding site; other site
438753007096	ATP-binding site [chemical binding]; other site
438753007097	DNA polymerase III subunit delta'; Validated; Region: PRK07471
438753007098	DNA polymerase III subunit delta'; Validated; Region: PRK08485
438753007099	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
438753007100	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
438753007101	active site
438753007102	HIGH motif; other site
438753007103	KMSKS motif; other site
438753007104	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
438753007105	tRNA binding surface [nucleotide binding]; other site
438753007106	anticodon binding site; other site
438753007107	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
438753007108	BioY family; Region: BioY; pfam02632
438753007109	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
438753007110	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
438753007111	active site
438753007112	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
438753007113	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
438753007114	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
438753007115	homodimer interface [polypeptide binding]; other site
438753007116	substrate-cofactor binding pocket; other site
438753007117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753007118	catalytic residue [active]
438753007119	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
438753007120	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753007121	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
438753007122	putative dimerization interface [polypeptide binding]; other site
438753007123	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
438753007124	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
438753007125	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
438753007126	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
438753007127	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
438753007128	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
438753007129	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
438753007130	enoyl-CoA hydratase; Validated; Region: PRK08139
438753007131	substrate binding site [chemical binding]; other site
438753007132	oxyanion hole (OAH) forming residues; other site
438753007133	trimer interface [polypeptide binding]; other site
438753007134	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
438753007135	CoenzymeA binding site [chemical binding]; other site
438753007136	subunit interaction site [polypeptide binding]; other site
438753007137	PHB binding site; other site
438753007138	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
438753007139	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
438753007140	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
438753007141	23S rRNA interface [nucleotide binding]; other site
438753007142	L3 interface [polypeptide binding]; other site
438753007143	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
438753007144	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
438753007145	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
438753007146	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
438753007147	active site
438753007148	catalytic tetrad [active]
438753007149	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
438753007150	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
438753007151	metal binding site [ion binding]; metal-binding site
438753007152	putative dimer interface [polypeptide binding]; other site
438753007153	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
438753007154	CPxP  motif; other site
438753007155	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
438753007156	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
438753007157	active site
438753007158	HIGH motif; other site
438753007159	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
438753007160	active site
438753007161	KMSKS motif; other site
438753007162	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
438753007163	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
438753007164	Competence protein; Region: Competence; pfam03772
438753007165	LexA repressor; Validated; Region: PRK00215
438753007166	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
438753007167	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
438753007168	Catalytic site [active]
438753007169	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
438753007170	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
438753007171	dimer interface [polypeptide binding]; other site
438753007172	putative functional site; other site
438753007173	putative MPT binding site; other site
438753007174	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
438753007175	trimer interface [polypeptide binding]; other site
438753007176	dimer interface [polypeptide binding]; other site
438753007177	putative active site [active]
438753007178	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
438753007179	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
438753007180	active site
438753007181	ribulose/triose binding site [chemical binding]; other site
438753007182	phosphate binding site [ion binding]; other site
438753007183	substrate (anthranilate) binding pocket [chemical binding]; other site
438753007184	product (indole) binding pocket [chemical binding]; other site
438753007185	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
438753007186	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
438753007187	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
438753007188	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
438753007189	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
438753007190	glutamine binding [chemical binding]; other site
438753007191	catalytic triad [active]
438753007192	anthranilate synthase component I; Provisional; Region: PRK13573
438753007193	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
438753007194	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
438753007195	SurA N-terminal domain; Region: SurA_N_3; cl07813
438753007196	periplasmic folding chaperone; Provisional; Region: PRK10788
438753007197	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
438753007198	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
438753007199	triosephosphate isomerase; Provisional; Region: PRK14565
438753007200	substrate binding site [chemical binding]; other site
438753007201	dimer interface [polypeptide binding]; other site
438753007202	catalytic triad [active]
438753007203	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
438753007204	MFS_1 like family; Region: MFS_1_like; pfam12832
438753007205	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
438753007206	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
438753007207	active site
438753007208	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
438753007209	anti sigma factor interaction site; other site
438753007210	regulatory phosphorylation site [posttranslational modification]; other site
438753007211	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
438753007212	Permease; Region: Permease; pfam02405
438753007213	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
438753007214	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
438753007215	Walker A/P-loop; other site
438753007216	ATP binding site [chemical binding]; other site
438753007217	Q-loop/lid; other site
438753007218	ABC transporter signature motif; other site
438753007219	Walker B; other site
438753007220	D-loop; other site
438753007221	H-loop/switch region; other site
438753007222	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
438753007223	mce related protein; Region: MCE; pfam02470
438753007224	Protein of unknown function (DUF330); Region: DUF330; cl01135
438753007225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
438753007226	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
438753007227	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
438753007228	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753007229	catalytic loop [active]
438753007230	iron binding site [ion binding]; other site
438753007231	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
438753007232	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
438753007233	Ligand binding site; other site
438753007234	Putative Catalytic site; other site
438753007235	DXD motif; other site
438753007236	glutamate racemase; Provisional; Region: PRK00865
438753007237	Transglycosylase SLT domain; Region: SLT_2; pfam13406
438753007238	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
438753007239	N-acetyl-D-glucosamine binding site [chemical binding]; other site
438753007240	catalytic residue [active]
438753007241	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
438753007242	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
438753007243	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
438753007244	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
438753007245	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
438753007246	RNA binding surface [nucleotide binding]; other site
438753007247	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
438753007248	MgtC family; Region: MgtC; pfam02308
438753007249	Bacterial SH3 domain; Region: SH3_3; pfam08239
438753007250	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
438753007251	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
438753007252	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
438753007253	ATP binding site [chemical binding]; other site
438753007254	active site
438753007255	substrate binding site [chemical binding]; other site
438753007256	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
438753007257	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
438753007258	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
438753007259	putative active site [active]
438753007260	catalytic triad [active]
438753007261	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
438753007262	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
438753007263	dimerization interface [polypeptide binding]; other site
438753007264	ATP binding site [chemical binding]; other site
438753007265	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
438753007266	dimerization interface [polypeptide binding]; other site
438753007267	ATP binding site [chemical binding]; other site
438753007268	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
438753007269	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
438753007270	active site
438753007271	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
438753007272	putative GSH binding site [chemical binding]; other site
438753007273	catalytic residues [active]
438753007274	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
438753007275	RelB antitoxin; Region: RelB; cl01171
438753007276	adenylosuccinate lyase; Provisional; Region: PRK07492
438753007277	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
438753007278	tetramer interface [polypeptide binding]; other site
438753007279	active site
438753007280	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
438753007281	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
438753007282	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
438753007283	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753007284	catalytic residue [active]
438753007285	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
438753007286	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
438753007287	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
438753007288	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
438753007289	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
438753007290	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
438753007291	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
438753007292	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
438753007293	acyl-activating enzyme (AAE) consensus motif; other site
438753007294	putative AMP binding site [chemical binding]; other site
438753007295	putative active site [active]
438753007296	putative CoA binding site [chemical binding]; other site
438753007297	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
438753007298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753007299	ABC-ATPase subunit interface; other site
438753007300	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
438753007301	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
438753007302	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
438753007303	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
438753007304	heme binding site [chemical binding]; other site
438753007305	ferroxidase pore; other site
438753007306	ferroxidase diiron center [ion binding]; other site
438753007307	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
438753007308	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753007309	PAS domain; Region: PAS_9; pfam13426
438753007310	putative active site [active]
438753007311	heme pocket [chemical binding]; other site
438753007312	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753007313	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753007314	dimer interface [polypeptide binding]; other site
438753007315	phosphorylation site [posttranslational modification]
438753007316	Phasin protein; Region: Phasin_2; cl11491
438753007317	Phasin protein; Region: Phasin_2; cl11491
438753007318	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
438753007319	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
438753007320	putative active site [active]
438753007321	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
438753007322	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
438753007323	putative active site [active]
438753007324	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
438753007325	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
438753007326	NADP binding site [chemical binding]; other site
438753007327	homopentamer interface [polypeptide binding]; other site
438753007328	substrate binding site [chemical binding]; other site
438753007329	active site
438753007330	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
438753007331	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
438753007332	substrate binding site [chemical binding]; other site
438753007333	ATP binding site [chemical binding]; other site
438753007334	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
438753007335	active site
438753007336	nucleotide binding site [chemical binding]; other site
438753007337	HIGH motif; other site
438753007338	KMSKS motif; other site
438753007339	acetylornithine deacetylase; Provisional; Region: PRK07522
438753007340	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
438753007341	metal binding site [ion binding]; metal-binding site
438753007342	putative dimer interface [polypeptide binding]; other site
438753007343	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
438753007344	homotrimer interface [polypeptide binding]; other site
438753007345	Walker A motif; other site
438753007346	GTP binding site [chemical binding]; other site
438753007347	Walker B motif; other site
438753007348	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
438753007349	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
438753007350	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
438753007351	homodimer interface [polypeptide binding]; other site
438753007352	Walker A motif; other site
438753007353	ATP binding site [chemical binding]; other site
438753007354	hydroxycobalamin binding site [chemical binding]; other site
438753007355	Walker B motif; other site
438753007356	Cobyric acid synthase [Coenzyme metabolism]; Region: CobQ; COG1492
438753007357	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
438753007358	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
438753007359	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
438753007360	catalytic triad [active]
438753007361	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
438753007362	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
438753007363	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
438753007364	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
438753007365	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
438753007366	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
438753007367	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
438753007368	putative NAD(P) binding site [chemical binding]; other site
438753007369	active site
438753007370	putative substrate binding site [chemical binding]; other site
438753007371	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
438753007372	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
438753007373	active site
438753007374	Predicted membrane protein [Function unknown]; Region: COG1238
438753007375	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
438753007376	putative hydrolase; Provisional; Region: PRK02113
438753007377	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
438753007378	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
438753007379	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
438753007380	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
438753007381	phosphate binding site [ion binding]; other site
438753007382	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
438753007383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753007384	putative substrate translocation pore; other site
438753007385	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
438753007386	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753007387	NAD(P) binding site [chemical binding]; other site
438753007388	active site
438753007389	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
438753007390	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
438753007391	L-rhamnonate dehydratase; Provisional; Region: PRK15440
438753007392	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
438753007393	putative active site pocket [active]
438753007394	putative metal binding site [ion binding]; other site
438753007395	D-galactonate transporter; Region: 2A0114; TIGR00893
438753007396	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753007397	Transcriptional regulator [Transcription]; Region: IclR; COG1414
438753007398	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
438753007399	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753007400	Uncharacterized conserved protein [Function unknown]; Region: COG2128
438753007401	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
438753007402	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
438753007403	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
438753007404	active site
438753007405	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753007406	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753007407	Walker A/P-loop; other site
438753007408	ATP binding site [chemical binding]; other site
438753007409	Q-loop/lid; other site
438753007410	ABC transporter signature motif; other site
438753007411	Walker B; other site
438753007412	D-loop; other site
438753007413	H-loop/switch region; other site
438753007414	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
438753007415	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753007416	substrate binding pocket [chemical binding]; other site
438753007417	membrane-bound complex binding site; other site
438753007418	hinge residues; other site
438753007419	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753007420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753007421	dimer interface [polypeptide binding]; other site
438753007422	conserved gate region; other site
438753007423	putative PBP binding loops; other site
438753007424	ABC-ATPase subunit interface; other site
438753007425	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
438753007426	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753007427	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
438753007428	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753007429	putative active site [active]
438753007430	heme pocket [chemical binding]; other site
438753007431	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753007432	dimer interface [polypeptide binding]; other site
438753007433	phosphorylation site [posttranslational modification]
438753007434	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753007435	ATP binding site [chemical binding]; other site
438753007436	G-X-G motif; other site
438753007437	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
438753007438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753007439	active site
438753007440	phosphorylation site [posttranslational modification]
438753007441	intermolecular recognition site; other site
438753007442	dimerization interface [polypeptide binding]; other site
438753007443	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
438753007444	DNA binding residues [nucleotide binding]
438753007445	dimerization interface [polypeptide binding]; other site
438753007446	Response regulator receiver domain; Region: Response_reg; pfam00072
438753007447	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753007448	active site
438753007449	phosphorylation site [posttranslational modification]
438753007450	intermolecular recognition site; other site
438753007451	dimerization interface [polypeptide binding]; other site
438753007452	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
438753007453	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
438753007454	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
438753007455	active site
438753007456	DNA binding site [nucleotide binding]
438753007457	Int/Topo IB signature motif; other site
438753007458	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
438753007459	dimerization interface [polypeptide binding]; other site
438753007460	metal binding site [ion binding]; metal-binding site
438753007461	Isochorismatase family; Region: Isochorismatase; pfam00857
438753007462	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
438753007463	catalytic triad [active]
438753007464	conserved cis-peptide bond; other site
438753007465	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753007466	non-specific DNA binding site [nucleotide binding]; other site
438753007467	salt bridge; other site
438753007468	sequence-specific DNA binding site [nucleotide binding]; other site
438753007469	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
438753007470	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
438753007471	Beta-lactamase; Region: Beta-lactamase; pfam00144
438753007472	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
438753007473	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
438753007474	PhoU domain; Region: PhoU; pfam01895
438753007475	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
438753007476	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
438753007477	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
438753007478	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
438753007479	DNA binding residues [nucleotide binding]
438753007480	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
438753007481	IHF dimer interface [polypeptide binding]; other site
438753007482	IHF - DNA interface [nucleotide binding]; other site
438753007483	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
438753007484	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
438753007485	dimer interface [polypeptide binding]; other site
438753007486	active site
438753007487	CoA binding pocket [chemical binding]; other site
438753007488	putative phosphate acyltransferase; Provisional; Region: PRK05331
438753007489	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
438753007490	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
438753007491	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
438753007492	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
438753007493	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
438753007494	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
438753007495	tetramer interface [polypeptide binding]; other site
438753007496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753007497	catalytic residue [active]
438753007498	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753007499	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
438753007500	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
438753007501	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
438753007502	putative active site [active]
438753007503	putative metal binding site [ion binding]; other site
438753007504	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
438753007505	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
438753007506	carboxylate-amine ligase; Provisional; Region: PRK13515
438753007507	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
438753007508	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
438753007509	RNA methyltransferase, RsmE family; Region: TIGR00046
438753007510	Cytochrome c; Region: Cytochrom_C; cl11414
438753007511	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
438753007512	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
438753007513	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
438753007514	homodimer interface [polypeptide binding]; other site
438753007515	NADP binding site [chemical binding]; other site
438753007516	substrate binding site [chemical binding]; other site
438753007517	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
438753007518	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
438753007519	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
438753007520	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
438753007521	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
438753007522	Usg-like family; Region: Usg; pfam06233
438753007523	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
438753007524	oligomerisation interface [polypeptide binding]; other site
438753007525	mobile loop; other site
438753007526	roof hairpin; other site
438753007527	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
438753007528	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
438753007529	ring oligomerisation interface [polypeptide binding]; other site
438753007530	ATP/Mg binding site [chemical binding]; other site
438753007531	stacking interactions; other site
438753007532	hinge regions; other site
438753007533	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
438753007534	MgtC family; Region: MgtC; pfam02308
438753007535	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
438753007536	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
438753007537	Acylphosphatase; Region: Acylphosphatase; pfam00708
438753007538	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
438753007539	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
438753007540	homotrimer interaction site [polypeptide binding]; other site
438753007541	putative active site [active]
438753007542	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
438753007543	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
438753007544	active site
438753007545	catalytic site [active]
438753007546	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
438753007547	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
438753007548	Protein of unknown function, DUF482; Region: DUF482; pfam04339
438753007549	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
438753007550	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
438753007551	active site
438753007552	hypothetical protein; Validated; Region: PRK06217
438753007553	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
438753007554	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
438753007555	active site
438753007556	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
438753007557	active site
438753007558	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
438753007559	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
438753007560	active site
438753007561	(T/H)XGH motif; other site
438753007562	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
438753007563	DNA gyrase subunit A; Validated; Region: PRK05560
438753007564	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
438753007565	CAP-like domain; other site
438753007566	active site
438753007567	primary dimer interface [polypeptide binding]; other site
438753007568	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
438753007569	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
438753007570	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
438753007571	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
438753007572	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
438753007573	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
438753007574	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
438753007575	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
438753007576	homoserine O-acetyltransferase; Provisional; Region: PRK06765
438753007577	Predicted acetyltransferase [General function prediction only]; Region: COG3153
438753007578	Coenzyme A binding pocket [chemical binding]; other site
438753007579	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
438753007580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753007581	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
438753007582	putative substrate translocation pore; other site
438753007583	glutathione reductase; Validated; Region: PRK06116
438753007584	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
438753007585	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
438753007586	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
438753007587	active site
438753007588	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
438753007589	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
438753007590	Probable Catalytic site; other site
438753007591	metal-binding site
438753007592	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
438753007593	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
438753007594	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753007595	3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129
438753007596	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
438753007597	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
438753007598	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753007599	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
438753007600	putative ligand binding site [chemical binding]; other site
438753007601	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
438753007602	YciI-like protein; Reviewed; Region: PRK12863
438753007603	short chain dehydrogenase; Provisional; Region: PRK07577
438753007604	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753007605	NAD(P) binding site [chemical binding]; other site
438753007606	active site
438753007607	Putative cyclase; Region: Cyclase; cl00814
438753007608	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
438753007609	Uncharacterized conserved protein [Function unknown]; Region: COG5649
438753007610	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753007611	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753007612	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
438753007613	Protein of unknown function (DUF993); Region: DUF993; pfam06187
438753007614	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
438753007615	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
438753007616	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
438753007617	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753007618	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753007619	Walker A/P-loop; other site
438753007620	ATP binding site [chemical binding]; other site
438753007621	Q-loop/lid; other site
438753007622	ABC transporter signature motif; other site
438753007623	Walker B; other site
438753007624	D-loop; other site
438753007625	H-loop/switch region; other site
438753007626	NMT1/THI5 like; Region: NMT1; pfam09084
438753007627	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753007628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753007629	dimer interface [polypeptide binding]; other site
438753007630	conserved gate region; other site
438753007631	ABC-ATPase subunit interface; other site
438753007632	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
438753007633	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753007634	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753007635	dimerization interface [polypeptide binding]; other site
438753007636	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
438753007637	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
438753007638	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
438753007639	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
438753007640	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
438753007641	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
438753007642	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
438753007643	putative active site [active]
438753007644	catalytic site [active]
438753007645	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
438753007646	putative active site [active]
438753007647	catalytic site [active]
438753007648	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
438753007649	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
438753007650	tetramer (dimer of dimers) interface [polypeptide binding]; other site
438753007651	active site
438753007652	dimer interface [polypeptide binding]; other site
438753007653	phosphoglycolate phosphatase; Provisional; Region: PRK13222
438753007654	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
438753007655	motif II; other site
438753007656	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
438753007657	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
438753007658	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
438753007659	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753007660	substrate binding pocket [chemical binding]; other site
438753007661	membrane-bound complex binding site; other site
438753007662	hinge residues; other site
438753007663	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753007664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753007665	dimer interface [polypeptide binding]; other site
438753007666	conserved gate region; other site
438753007667	putative PBP binding loops; other site
438753007668	ABC-ATPase subunit interface; other site
438753007669	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753007670	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753007671	Walker A/P-loop; other site
438753007672	ATP binding site [chemical binding]; other site
438753007673	Q-loop/lid; other site
438753007674	ABC transporter signature motif; other site
438753007675	Walker B; other site
438753007676	D-loop; other site
438753007677	H-loop/switch region; other site
438753007678	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
438753007679	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
438753007680	rRNA binding site [nucleotide binding]; other site
438753007681	predicted 30S ribosome binding site; other site
438753007682	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
438753007683	DEAD-like helicases superfamily; Region: DEXDc; smart00487
438753007684	ATP binding site [chemical binding]; other site
438753007685	Mg++ binding site [ion binding]; other site
438753007686	motif III; other site
438753007687	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
438753007688	nucleotide binding region [chemical binding]; other site
438753007689	ATP-binding site [chemical binding]; other site
438753007690	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
438753007691	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
438753007692	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
438753007693	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753007694	substrate binding pocket [chemical binding]; other site
438753007695	membrane-bound complex binding site; other site
438753007696	hinge residues; other site
438753007697	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
438753007698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753007699	dimer interface [polypeptide binding]; other site
438753007700	conserved gate region; other site
438753007701	putative PBP binding loops; other site
438753007702	ABC-ATPase subunit interface; other site
438753007703	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
438753007704	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753007705	Walker A/P-loop; other site
438753007706	ATP binding site [chemical binding]; other site
438753007707	Q-loop/lid; other site
438753007708	ABC transporter signature motif; other site
438753007709	Walker B; other site
438753007710	D-loop; other site
438753007711	H-loop/switch region; other site
438753007712	TOBE domain; Region: TOBE; pfam03459
438753007713	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
438753007714	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
438753007715	flavodoxin FldA; Validated; Region: PRK09267
438753007716	ketol-acid reductoisomerase; Provisional; Region: PRK05479
438753007717	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
438753007718	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
438753007719	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
438753007720	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
438753007721	putative valine binding site [chemical binding]; other site
438753007722	dimer interface [polypeptide binding]; other site
438753007723	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
438753007724	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
438753007725	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
438753007726	PYR/PP interface [polypeptide binding]; other site
438753007727	dimer interface [polypeptide binding]; other site
438753007728	TPP binding site [chemical binding]; other site
438753007729	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
438753007730	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
438753007731	TPP-binding site [chemical binding]; other site
438753007732	dimer interface [polypeptide binding]; other site
438753007733	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
438753007734	UbiA prenyltransferase family; Region: UbiA; pfam01040
438753007735	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
438753007736	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
438753007737	active site
438753007738	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
438753007739	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
438753007740	putative acyl-acceptor binding pocket; other site
438753007741	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
438753007742	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
438753007743	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
438753007744	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
438753007745	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
438753007746	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
438753007747	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
438753007748	generic binding surface II; other site
438753007749	generic binding surface I; other site
438753007750	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
438753007751	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
438753007752	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
438753007753	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
438753007754	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
438753007755	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
438753007756	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
438753007757	nucleoside/Zn binding site; other site
438753007758	dimer interface [polypeptide binding]; other site
438753007759	catalytic motif [active]
438753007760	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
438753007761	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
438753007762	RNA binding surface [nucleotide binding]; other site
438753007763	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
438753007764	active site
438753007765	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
438753007766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753007767	S-adenosylmethionine binding site [chemical binding]; other site
438753007768	putative mechanosensitive channel protein; Provisional; Region: PRK11465
438753007769	Mechanosensitive ion channel; Region: MS_channel; pfam00924
438753007770	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
438753007771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753007772	ATP binding site [chemical binding]; other site
438753007773	Mg2+ binding site [ion binding]; other site
438753007774	G-X-G motif; other site
438753007775	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
438753007776	ATP binding site [chemical binding]; other site
438753007777	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
438753007778	Response regulator receiver domain; Region: Response_reg; pfam00072
438753007779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753007780	active site
438753007781	phosphorylation site [posttranslational modification]
438753007782	intermolecular recognition site; other site
438753007783	dimerization interface [polypeptide binding]; other site
438753007784	elongation factor P; Validated; Region: PRK00529
438753007785	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
438753007786	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
438753007787	RNA binding site [nucleotide binding]; other site
438753007788	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
438753007789	RNA binding site [nucleotide binding]; other site
438753007790	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
438753007791	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
438753007792	dimer interface [polypeptide binding]; other site
438753007793	motif 1; other site
438753007794	active site
438753007795	motif 2; other site
438753007796	motif 3; other site
438753007797	Predicted membrane protein [Function unknown]; Region: COG2259
438753007798	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
438753007799	RNA/DNA hybrid binding site [nucleotide binding]; other site
438753007800	active site
438753007801	Predicted metalloprotease [General function prediction only]; Region: COG2321
438753007802	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
438753007803	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
438753007804	MPT binding site; other site
438753007805	trimer interface [polypeptide binding]; other site
438753007806	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
438753007807	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
438753007808	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
438753007809	active site
438753007810	acyl carrier protein; Provisional; Region: PRK06508
438753007811	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
438753007812	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
438753007813	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
438753007814	active site
438753007815	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
438753007816	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
438753007817	dimer interface [polypeptide binding]; other site
438753007818	active site
438753007819	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753007820	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
438753007821	NAD(P) binding site [chemical binding]; other site
438753007822	active site
438753007823	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
438753007824	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
438753007825	NAD(P) binding site [chemical binding]; other site
438753007826	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
438753007827	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
438753007828	putative acyl-acceptor binding pocket; other site
438753007829	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753007830	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753007831	substrate binding pocket [chemical binding]; other site
438753007832	membrane-bound complex binding site; other site
438753007833	hinge residues; other site
438753007834	Response regulator receiver domain; Region: Response_reg; pfam00072
438753007835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753007836	active site
438753007837	phosphorylation site [posttranslational modification]
438753007838	intermolecular recognition site; other site
438753007839	dimerization interface [polypeptide binding]; other site
438753007840	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753007841	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753007842	metal binding site [ion binding]; metal-binding site
438753007843	active site
438753007844	I-site; other site
438753007845	Response regulator receiver domain; Region: Response_reg; pfam00072
438753007846	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753007847	active site
438753007848	phosphorylation site [posttranslational modification]
438753007849	intermolecular recognition site; other site
438753007850	dimerization interface [polypeptide binding]; other site
438753007851	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753007852	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753007853	metal binding site [ion binding]; metal-binding site
438753007854	active site
438753007855	I-site; other site
438753007856	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
438753007857	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
438753007858	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
438753007859	NAD binding site [chemical binding]; other site
438753007860	ATP-grasp domain; Region: ATP-grasp; pfam02222
438753007861	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
438753007862	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753007863	dimerization interface [polypeptide binding]; other site
438753007864	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753007865	dimer interface [polypeptide binding]; other site
438753007866	putative CheW interface [polypeptide binding]; other site
438753007867	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
438753007868	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
438753007869	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
438753007870	DctM-like transporters; Region: DctM; pfam06808
438753007871	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
438753007872	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
438753007873	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
438753007874	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
438753007875	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
438753007876	dimer interaction site [polypeptide binding]; other site
438753007877	substrate-binding tunnel; other site
438753007878	active site
438753007879	catalytic site [active]
438753007880	substrate binding site [chemical binding]; other site
438753007881	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
438753007882	acetate kinase; Provisional; Region: PRK07058
438753007883	propionate/acetate kinase; Provisional; Region: PRK12379
438753007884	phosphogluconate dehydratase; Validated; Region: PRK09054
438753007885	6-phosphogluconate dehydratase; Region: edd; TIGR01196
438753007886	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
438753007887	Protein export membrane protein; Region: SecD_SecF; cl14618
438753007888	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
438753007889	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753007890	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753007891	RNA polymerase sigma factor; Reviewed; Region: PRK05602
438753007892	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753007893	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
438753007894	DNA binding residues [nucleotide binding]
438753007895	Heavy-metal resistance; Region: Metal_resist; pfam13801
438753007896	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
438753007897	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753007898	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753007899	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
438753007900	Protein export membrane protein; Region: SecD_SecF; cl14618
438753007901	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
438753007902	TspO/MBR family; Region: TspO_MBR; pfam03073
438753007903	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
438753007904	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
438753007905	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
438753007906	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
438753007907	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
438753007908	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
438753007909	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
438753007910	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
438753007911	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753007912	S-adenosylmethionine binding site [chemical binding]; other site
438753007913	Cupin domain; Region: Cupin_2; pfam07883
438753007914	allantoate amidohydrolase; Reviewed; Region: PRK12893
438753007915	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
438753007916	active site
438753007917	metal binding site [ion binding]; metal-binding site
438753007918	dimer interface [polypeptide binding]; other site
438753007919	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
438753007920	aspartate aminotransferase; Provisional; Region: PRK06225
438753007921	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753007922	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753007923	homodimer interface [polypeptide binding]; other site
438753007924	catalytic residue [active]
438753007925	short chain dehydrogenase; Provisional; Region: PRK06125
438753007926	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753007927	NAD(P) binding site [chemical binding]; other site
438753007928	active site
438753007929	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
438753007930	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753007931	DNA-binding site [nucleotide binding]; DNA binding site
438753007932	FCD domain; Region: FCD; pfam07729
438753007933	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753007934	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753007935	Walker A/P-loop; other site
438753007936	ATP binding site [chemical binding]; other site
438753007937	Q-loop/lid; other site
438753007938	ABC transporter signature motif; other site
438753007939	Walker B; other site
438753007940	D-loop; other site
438753007941	H-loop/switch region; other site
438753007942	aldolase II superfamily protein; Provisional; Region: PRK07044
438753007943	intersubunit interface [polypeptide binding]; other site
438753007944	active site
438753007945	Zn2+ binding site [ion binding]; other site
438753007946	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753007947	NMT1/THI5 like; Region: NMT1; pfam09084
438753007948	substrate binding pocket [chemical binding]; other site
438753007949	membrane-bound complex binding site; other site
438753007950	hinge residues; other site
438753007951	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753007952	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
438753007953	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753007954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
438753007955	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
438753007956	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
438753007957	active site
438753007958	non-prolyl cis peptide bond; other site
438753007959	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
438753007960	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753007961	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
438753007962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
438753007963	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
438753007964	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753007965	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
438753007966	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753007967	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753007968	DNA-binding site [nucleotide binding]; DNA binding site
438753007969	FCD domain; Region: FCD; pfam07729
438753007970	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
438753007971	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753007972	dimer interface [polypeptide binding]; other site
438753007973	conserved gate region; other site
438753007974	putative PBP binding loops; other site
438753007975	ABC-ATPase subunit interface; other site
438753007976	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
438753007977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753007978	dimer interface [polypeptide binding]; other site
438753007979	conserved gate region; other site
438753007980	putative PBP binding loops; other site
438753007981	ABC-ATPase subunit interface; other site
438753007982	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
438753007983	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
438753007984	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
438753007985	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
438753007986	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
438753007987	active site
438753007988	dimer interface [polypeptide binding]; other site
438753007989	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
438753007990	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753007991	Walker A/P-loop; other site
438753007992	ATP binding site [chemical binding]; other site
438753007993	Q-loop/lid; other site
438753007994	ABC transporter signature motif; other site
438753007995	Walker B; other site
438753007996	D-loop; other site
438753007997	H-loop/switch region; other site
438753007998	TOBE domain; Region: TOBE_2; pfam08402
438753007999	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
438753008000	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008001	dimer interface [polypeptide binding]; other site
438753008002	conserved gate region; other site
438753008003	putative PBP binding loops; other site
438753008004	ABC-ATPase subunit interface; other site
438753008005	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
438753008006	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008007	dimer interface [polypeptide binding]; other site
438753008008	conserved gate region; other site
438753008009	putative PBP binding loops; other site
438753008010	ABC-ATPase subunit interface; other site
438753008011	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
438753008012	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
438753008013	Isochorismatase family; Region: Isochorismatase; pfam00857
438753008014	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
438753008015	catalytic triad [active]
438753008016	conserved cis-peptide bond; other site
438753008017	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
438753008018	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753008019	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
438753008020	dimerization interface [polypeptide binding]; other site
438753008021	substrate binding pocket [chemical binding]; other site
438753008022	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753008023	dimerization interface [polypeptide binding]; other site
438753008024	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
438753008025	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753008026	dimer interface [polypeptide binding]; other site
438753008027	putative CheW interface [polypeptide binding]; other site
438753008028	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
438753008029	AAA domain; Region: AAA_33; pfam13671
438753008030	active site
438753008031	thymidine phosphorylase; Provisional; Region: PRK04350
438753008032	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
438753008033	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
438753008034	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
438753008035	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
438753008036	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
438753008037	dimerization interface [polypeptide binding]; other site
438753008038	active site
438753008039	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753008040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008041	dimer interface [polypeptide binding]; other site
438753008042	conserved gate region; other site
438753008043	putative PBP binding loops; other site
438753008044	ABC-ATPase subunit interface; other site
438753008045	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753008046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
438753008047	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753008048	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753008049	Walker A/P-loop; other site
438753008050	ATP binding site [chemical binding]; other site
438753008051	Q-loop/lid; other site
438753008052	ABC transporter signature motif; other site
438753008053	Walker B; other site
438753008054	D-loop; other site
438753008055	H-loop/switch region; other site
438753008056	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
438753008057	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
438753008058	MarR family; Region: MarR_2; cl17246
438753008059	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
438753008060	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
438753008061	FAD binding domain; Region: FAD_binding_4; pfam01565
438753008062	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
438753008063	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
438753008064	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
438753008065	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753008066	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
438753008067	Walker A/P-loop; other site
438753008068	ATP binding site [chemical binding]; other site
438753008069	Q-loop/lid; other site
438753008070	ABC transporter signature motif; other site
438753008071	Walker B; other site
438753008072	D-loop; other site
438753008073	H-loop/switch region; other site
438753008074	TOBE domain; Region: TOBE_2; pfam08402
438753008075	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
438753008076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008077	dimer interface [polypeptide binding]; other site
438753008078	conserved gate region; other site
438753008079	putative PBP binding loops; other site
438753008080	ABC-ATPase subunit interface; other site
438753008081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008082	dimer interface [polypeptide binding]; other site
438753008083	conserved gate region; other site
438753008084	putative PBP binding loops; other site
438753008085	ABC-ATPase subunit interface; other site
438753008086	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
438753008087	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
438753008088	inhibitor site; inhibition site
438753008089	active site
438753008090	dimer interface [polypeptide binding]; other site
438753008091	catalytic residue [active]
438753008092	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
438753008093	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
438753008094	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753008095	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
438753008096	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
438753008097	active site
438753008098	catalytic site [active]
438753008099	substrate binding site [chemical binding]; other site
438753008100	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
438753008101	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753008102	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753008103	DNA-binding site [nucleotide binding]; DNA binding site
438753008104	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
438753008105	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753008106	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753008107	substrate binding pocket [chemical binding]; other site
438753008108	membrane-bound complex binding site; other site
438753008109	hinge residues; other site
438753008110	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753008111	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753008112	Walker A/P-loop; other site
438753008113	ATP binding site [chemical binding]; other site
438753008114	Q-loop/lid; other site
438753008115	ABC transporter signature motif; other site
438753008116	Walker B; other site
438753008117	D-loop; other site
438753008118	H-loop/switch region; other site
438753008119	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753008120	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008121	dimer interface [polypeptide binding]; other site
438753008122	conserved gate region; other site
438753008123	putative PBP binding loops; other site
438753008124	ABC-ATPase subunit interface; other site
438753008125	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008126	dimer interface [polypeptide binding]; other site
438753008127	conserved gate region; other site
438753008128	putative PBP binding loops; other site
438753008129	ABC-ATPase subunit interface; other site
438753008130	N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569
438753008131	Predicted amidohydrolase [General function prediction only]; Region: COG0388
438753008132	tetramer interface [polypeptide binding]; other site
438753008133	active site
438753008134	catalytic triad [active]
438753008135	dimer interface [polypeptide binding]; other site
438753008136	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
438753008137	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
438753008138	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753008139	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753008140	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
438753008141	putative dimerization interface [polypeptide binding]; other site
438753008142	NMT1/THI5 like; Region: NMT1; pfam09084
438753008143	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753008144	membrane-bound complex binding site; other site
438753008145	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
438753008146	catalytic triad [active]
438753008147	Isochorismatase family; Region: Isochorismatase; pfam00857
438753008148	conserved cis-peptide bond; other site
438753008149	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
438753008150	homotrimer interaction site [polypeptide binding]; other site
438753008151	putative active site [active]
438753008152	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753008153	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008154	dimer interface [polypeptide binding]; other site
438753008155	conserved gate region; other site
438753008156	putative PBP binding loops; other site
438753008157	ABC-ATPase subunit interface; other site
438753008158	pyrimidine utilization protein D; Region: RutD; TIGR03611
438753008159	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753008160	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753008161	Walker A/P-loop; other site
438753008162	ATP binding site [chemical binding]; other site
438753008163	Q-loop/lid; other site
438753008164	ABC transporter signature motif; other site
438753008165	Walker B; other site
438753008166	D-loop; other site
438753008167	H-loop/switch region; other site
438753008168	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753008169	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753008170	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
438753008171	putative dimerization interface [polypeptide binding]; other site
438753008172	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753008173	Amidase; Region: Amidase; cl11426
438753008174	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
438753008175	CoA-transferase family III; Region: CoA_transf_3; pfam02515
438753008176	enoyl-CoA hydratase; Provisional; Region: PRK06127
438753008177	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
438753008178	substrate binding site [chemical binding]; other site
438753008179	oxyanion hole (OAH) forming residues; other site
438753008180	trimer interface [polypeptide binding]; other site
438753008181	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
438753008182	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
438753008183	substrate binding pocket [chemical binding]; other site
438753008184	membrane-bound complex binding site; other site
438753008185	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753008186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008187	dimer interface [polypeptide binding]; other site
438753008188	conserved gate region; other site
438753008189	putative PBP binding loops; other site
438753008190	ABC-ATPase subunit interface; other site
438753008191	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753008192	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753008193	Walker A/P-loop; other site
438753008194	ATP binding site [chemical binding]; other site
438753008195	Q-loop/lid; other site
438753008196	ABC transporter signature motif; other site
438753008197	Walker B; other site
438753008198	D-loop; other site
438753008199	H-loop/switch region; other site
438753008200	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
438753008201	putative active site [active]
438753008202	putative catalytic site [active]
438753008203	short chain dehydrogenase; Provisional; Region: PRK06125
438753008204	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753008205	NAD(P) binding site [chemical binding]; other site
438753008206	active site
438753008207	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753008208	Uncharacterized conserved protein [Function unknown]; Region: COG3777
438753008209	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
438753008210	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
438753008211	active site 2 [active]
438753008212	active site 1 [active]
438753008213	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
438753008214	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
438753008215	active site
438753008216	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
438753008217	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
438753008218	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
438753008219	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753008220	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753008221	metal binding site [ion binding]; metal-binding site
438753008222	active site
438753008223	I-site; other site
438753008224	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
438753008225	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753008226	Mg2+ binding site [ion binding]; other site
438753008227	G-X-G motif; other site
438753008228	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
438753008229	anchoring element; other site
438753008230	dimer interface [polypeptide binding]; other site
438753008231	ATP binding site [chemical binding]; other site
438753008232	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
438753008233	active site
438753008234	metal binding site [ion binding]; metal-binding site
438753008235	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
438753008236	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
438753008237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753008238	putative substrate translocation pore; other site
438753008239	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
438753008240	DEAD-like helicases superfamily; Region: DEXDc; smart00487
438753008241	ATP binding site [chemical binding]; other site
438753008242	Mg++ binding site [ion binding]; other site
438753008243	motif III; other site
438753008244	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
438753008245	nucleotide binding region [chemical binding]; other site
438753008246	ATP-binding site [chemical binding]; other site
438753008247	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753008248	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753008249	metal binding site [ion binding]; metal-binding site
438753008250	active site
438753008251	I-site; other site
438753008252	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753008253	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753008254	metal binding site [ion binding]; metal-binding site
438753008255	active site
438753008256	I-site; other site
438753008257	TfoX N-terminal domain; Region: TfoX_N; pfam04993
438753008258	ATP12 chaperone protein; Region: ATP12; cl02228
438753008259	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
438753008260	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
438753008261	motif II; other site
438753008262	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
438753008263	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
438753008264	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
438753008265	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
438753008266	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
438753008267	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
438753008268	RNA binding surface [nucleotide binding]; other site
438753008269	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
438753008270	active site
438753008271	CrcB-like protein; Region: CRCB; cl09114
438753008272	recombination factor protein RarA; Reviewed; Region: PRK13342
438753008273	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753008274	Walker A motif; other site
438753008275	ATP binding site [chemical binding]; other site
438753008276	Walker B motif; other site
438753008277	arginine finger; other site
438753008278	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
438753008279	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
438753008280	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
438753008281	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
438753008282	protein binding site [polypeptide binding]; other site
438753008283	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
438753008284	protein binding site [polypeptide binding]; other site
438753008285	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
438753008286	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
438753008287	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
438753008288	alphaNTD - beta interaction site [polypeptide binding]; other site
438753008289	alphaNTD homodimer interface [polypeptide binding]; other site
438753008290	alphaNTD - beta' interaction site [polypeptide binding]; other site
438753008291	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
438753008292	30S ribosomal protein S11; Validated; Region: PRK05309
438753008293	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
438753008294	30S ribosomal protein S13; Region: bact_S13; TIGR03631
438753008295	adenylate kinase; Reviewed; Region: adk; PRK00279
438753008296	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
438753008297	AMP-binding site [chemical binding]; other site
438753008298	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
438753008299	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
438753008300	SecY translocase; Region: SecY; pfam00344
438753008301	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
438753008302	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
438753008303	23S rRNA binding site [nucleotide binding]; other site
438753008304	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
438753008305	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
438753008306	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
438753008307	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
438753008308	5S rRNA interface [nucleotide binding]; other site
438753008309	23S rRNA interface [nucleotide binding]; other site
438753008310	L5 interface [polypeptide binding]; other site
438753008311	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
438753008312	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
438753008313	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
438753008314	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
438753008315	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
438753008316	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
438753008317	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
438753008318	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
438753008319	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
438753008320	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
438753008321	RNA binding site [nucleotide binding]; other site
438753008322	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
438753008323	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
438753008324	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
438753008325	putative translocon interaction site; other site
438753008326	23S rRNA interface [nucleotide binding]; other site
438753008327	signal recognition particle (SRP54) interaction site; other site
438753008328	L23 interface [polypeptide binding]; other site
438753008329	trigger factor interaction site; other site
438753008330	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
438753008331	23S rRNA interface [nucleotide binding]; other site
438753008332	5S rRNA interface [nucleotide binding]; other site
438753008333	putative antibiotic binding site [chemical binding]; other site
438753008334	L25 interface [polypeptide binding]; other site
438753008335	L27 interface [polypeptide binding]; other site
438753008336	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
438753008337	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
438753008338	G-X-X-G motif; other site
438753008339	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
438753008340	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
438753008341	putative translocon binding site; other site
438753008342	protein-rRNA interface [nucleotide binding]; other site
438753008343	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
438753008344	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
438753008345	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
438753008346	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
438753008347	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
438753008348	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
438753008349	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
438753008350	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
438753008351	elongation factor Tu; Reviewed; Region: PRK00049
438753008352	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
438753008353	G1 box; other site
438753008354	GEF interaction site [polypeptide binding]; other site
438753008355	GTP/Mg2+ binding site [chemical binding]; other site
438753008356	Switch I region; other site
438753008357	G2 box; other site
438753008358	G3 box; other site
438753008359	Switch II region; other site
438753008360	G4 box; other site
438753008361	G5 box; other site
438753008362	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
438753008363	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
438753008364	Antibiotic Binding Site [chemical binding]; other site
438753008365	elongation factor G; Reviewed; Region: PRK00007
438753008366	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
438753008367	G1 box; other site
438753008368	putative GEF interaction site [polypeptide binding]; other site
438753008369	GTP/Mg2+ binding site [chemical binding]; other site
438753008370	Switch I region; other site
438753008371	G2 box; other site
438753008372	G3 box; other site
438753008373	Switch II region; other site
438753008374	G4 box; other site
438753008375	G5 box; other site
438753008376	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
438753008377	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
438753008378	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
438753008379	30S ribosomal protein S7; Validated; Region: PRK05302
438753008380	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
438753008381	S17 interaction site [polypeptide binding]; other site
438753008382	S8 interaction site; other site
438753008383	16S rRNA interaction site [nucleotide binding]; other site
438753008384	streptomycin interaction site [chemical binding]; other site
438753008385	23S rRNA interaction site [nucleotide binding]; other site
438753008386	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
438753008387	Repair protein; Region: Repair_PSII; cl01535
438753008388	Repair protein; Region: Repair_PSII; cl01535
438753008389	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
438753008390	Repair protein; Region: Repair_PSII; pfam04536
438753008391	LemA family; Region: LemA; pfam04011
438753008392	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
438753008393	GIY-YIG motif/motif A; other site
438753008394	putative active site [active]
438753008395	putative metal binding site [ion binding]; other site
438753008396	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753008397	dimerization interface [polypeptide binding]; other site
438753008398	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753008399	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753008400	dimer interface [polypeptide binding]; other site
438753008401	putative CheW interface [polypeptide binding]; other site
438753008402	Putative ParB-like nuclease; Region: ParBc_2; cl17538
438753008403	fumarate hydratase; Reviewed; Region: fumC; PRK00485
438753008404	Class II fumarases; Region: Fumarase_classII; cd01362
438753008405	active site
438753008406	tetramer interface [polypeptide binding]; other site
438753008407	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
438753008408	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
438753008409	HflK protein; Region: hflK; TIGR01933
438753008410	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
438753008411	HflC protein; Region: hflC; TIGR01932
438753008412	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
438753008413	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
438753008414	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
438753008415	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
438753008416	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
438753008417	protein binding site [polypeptide binding]; other site
438753008418	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
438753008419	protein binding site [polypeptide binding]; other site
438753008420	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753008421	dimerization interface [polypeptide binding]; other site
438753008422	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753008423	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753008424	dimer interface [polypeptide binding]; other site
438753008425	putative CheW interface [polypeptide binding]; other site
438753008426	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
438753008427	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
438753008428	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
438753008429	motif II; other site
438753008430	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
438753008431	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
438753008432	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
438753008433	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
438753008434	amidase; Provisional; Region: PRK06170
438753008435	Amidase; Region: Amidase; cl11426
438753008436	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753008437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008438	dimer interface [polypeptide binding]; other site
438753008439	conserved gate region; other site
438753008440	putative PBP binding loops; other site
438753008441	ABC-ATPase subunit interface; other site
438753008442	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753008443	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753008444	Walker A/P-loop; other site
438753008445	ATP binding site [chemical binding]; other site
438753008446	Q-loop/lid; other site
438753008447	ABC transporter signature motif; other site
438753008448	Walker B; other site
438753008449	D-loop; other site
438753008450	H-loop/switch region; other site
438753008451	NMT1/THI5 like; Region: NMT1; pfam09084
438753008452	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
438753008453	membrane-bound complex binding site; other site
438753008454	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
438753008455	Catalytic domain of Protein Kinases; Region: PKc; cd00180
438753008456	active site
438753008457	ATP binding site [chemical binding]; other site
438753008458	substrate binding site [chemical binding]; other site
438753008459	activation loop (A-loop); other site
438753008460	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
438753008461	active site
438753008462	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
438753008463	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
438753008464	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
438753008465	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
438753008466	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
438753008467	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753008468	Walker A motif; other site
438753008469	ATP binding site [chemical binding]; other site
438753008470	Walker B motif; other site
438753008471	arginine finger; other site
438753008472	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753008473	Walker A motif; other site
438753008474	ATP binding site [chemical binding]; other site
438753008475	Walker B motif; other site
438753008476	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
438753008477	Trm112p-like protein; Region: Trm112p; cl01066
438753008478	Methyltransferase domain; Region: Methyltransf_31; pfam13847
438753008479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753008480	S-adenosylmethionine binding site [chemical binding]; other site
438753008481	Protein of unknown function (DUF796); Region: DUF796; pfam05638
438753008482	Protein of unknown function (DUF796); Region: DUF796; pfam05638
438753008483	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
438753008484	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
438753008485	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
438753008486	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
438753008487	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
438753008488	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
438753008489	phosphopeptide binding site; other site
438753008490	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
438753008491	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
438753008492	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
438753008493	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
438753008494	ligand binding site [chemical binding]; other site
438753008495	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
438753008496	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
438753008497	G1 box; other site
438753008498	GTP/Mg2+ binding site [chemical binding]; other site
438753008499	Switch I region; other site
438753008500	G3 box; other site
438753008501	Switch II region; other site
438753008502	G4 box; other site
438753008503	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
438753008504	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
438753008505	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
438753008506	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
438753008507	Protein of unknown function (DUF770); Region: DUF770; pfam05591
438753008508	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
438753008509	Protein of unknown function (DUF877); Region: DUF877; pfam05943
438753008510	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
438753008511	Protein of unknown function (DUF877); Region: DUF877; pfam05943
438753008512	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
438753008513	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753008514	TPR motif; other site
438753008515	ImpE protein; Region: ImpE; pfam07024
438753008516	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
438753008517	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
438753008518	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
438753008519	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
438753008520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753008521	S-adenosylmethionine binding site [chemical binding]; other site
438753008522	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
438753008523	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
438753008524	ThiC-associated domain; Region: ThiC-associated; pfam13667
438753008525	ThiC family; Region: ThiC; pfam01964
438753008526	Cupin domain; Region: Cupin_2; cl17218
438753008527	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
438753008528	homotrimer interaction site [polypeptide binding]; other site
438753008529	putative active site [active]
438753008530	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
438753008531	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
438753008532	Transcriptional regulators [Transcription]; Region: PurR; COG1609
438753008533	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
438753008534	DNA binding site [nucleotide binding]
438753008535	domain linker motif; other site
438753008536	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
438753008537	putative dimerization interface [polypeptide binding]; other site
438753008538	putative ligand binding site [chemical binding]; other site
438753008539	EthD domain; Region: EthD; cl17553
438753008540	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
438753008541	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
438753008542	putative NAD(P) binding site [chemical binding]; other site
438753008543	catalytic Zn binding site [ion binding]; other site
438753008544	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
438753008545	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
438753008546	NADP binding site [chemical binding]; other site
438753008547	homodimer interface [polypeptide binding]; other site
438753008548	active site
438753008549	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753008550	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753008551	substrate binding pocket [chemical binding]; other site
438753008552	membrane-bound complex binding site; other site
438753008553	hinge residues; other site
438753008554	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008555	dimer interface [polypeptide binding]; other site
438753008556	conserved gate region; other site
438753008557	putative PBP binding loops; other site
438753008558	ABC-ATPase subunit interface; other site
438753008559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008560	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753008561	dimer interface [polypeptide binding]; other site
438753008562	conserved gate region; other site
438753008563	putative PBP binding loops; other site
438753008564	ABC-ATPase subunit interface; other site
438753008565	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753008566	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753008567	Walker A/P-loop; other site
438753008568	ATP binding site [chemical binding]; other site
438753008569	Q-loop/lid; other site
438753008570	ABC transporter signature motif; other site
438753008571	Walker B; other site
438753008572	D-loop; other site
438753008573	H-loop/switch region; other site
438753008574	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
438753008575	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
438753008576	putative ligand binding site [chemical binding]; other site
438753008577	NAD binding site [chemical binding]; other site
438753008578	catalytic site [active]
438753008579	6-phosphogluconolactonase; Provisional; Region: PRK11028
438753008580	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753008581	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753008582	DNA-binding site [nucleotide binding]; DNA binding site
438753008583	FCD domain; Region: FCD; pfam07729
438753008584	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753008585	Amidase; Region: Amidase; cl11426
438753008586	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753008587	Amidase; Region: Amidase; cl11426
438753008588	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753008589	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
438753008590	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753008591	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
438753008592	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753008593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008594	dimer interface [polypeptide binding]; other site
438753008595	conserved gate region; other site
438753008596	putative PBP binding loops; other site
438753008597	ABC-ATPase subunit interface; other site
438753008598	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
438753008599	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
438753008600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008601	dimer interface [polypeptide binding]; other site
438753008602	conserved gate region; other site
438753008603	putative PBP binding loops; other site
438753008604	ABC-ATPase subunit interface; other site
438753008605	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
438753008606	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753008607	Walker A/P-loop; other site
438753008608	ATP binding site [chemical binding]; other site
438753008609	Q-loop/lid; other site
438753008610	ABC transporter signature motif; other site
438753008611	Walker B; other site
438753008612	D-loop; other site
438753008613	H-loop/switch region; other site
438753008614	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
438753008615	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
438753008616	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753008617	Walker A/P-loop; other site
438753008618	ATP binding site [chemical binding]; other site
438753008619	Q-loop/lid; other site
438753008620	ABC transporter signature motif; other site
438753008621	Walker B; other site
438753008622	D-loop; other site
438753008623	H-loop/switch region; other site
438753008624	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753008625	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
438753008626	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
438753008627	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
438753008628	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753008629	Amidase; Region: Amidase; pfam01425
438753008630	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753008631	Amidase; Region: Amidase; cl11426
438753008632	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753008633	Amidase; Region: Amidase; pfam01425
438753008634	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753008635	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753008636	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753008637	Autotransporter beta-domain; Region: Autotransporter; pfam03797
438753008638	galactarate dehydratase; Region: galactar-dH20; TIGR03248
438753008639	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
438753008640	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
438753008641	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
438753008642	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
438753008643	NAD(P) binding site [chemical binding]; other site
438753008644	catalytic residues [active]
438753008645	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
438753008646	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
438753008647	putative active site [active]
438753008648	catalytic residue [active]
438753008649	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
438753008650	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753008651	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
438753008652	putative dimerization interface [polypeptide binding]; other site
438753008653	putative substrate binding pocket [chemical binding]; other site
438753008654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753008655	D-galactonate transporter; Region: 2A0114; TIGR00893
438753008656	putative substrate translocation pore; other site
438753008657	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
438753008658	Domain of unknown function DUF20; Region: UPF0118; pfam01594
438753008659	hypothetical protein; Validated; Region: PRK08245
438753008660	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
438753008661	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753008662	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008663	putative PBP binding loops; other site
438753008664	ABC-ATPase subunit interface; other site
438753008665	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753008666	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753008667	Walker A/P-loop; other site
438753008668	ATP binding site [chemical binding]; other site
438753008669	Q-loop/lid; other site
438753008670	ABC transporter signature motif; other site
438753008671	Walker B; other site
438753008672	D-loop; other site
438753008673	H-loop/switch region; other site
438753008674	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
438753008675	NMT1-like family; Region: NMT1_2; pfam13379
438753008676	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753008677	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753008678	DNA-binding site [nucleotide binding]; DNA binding site
438753008679	FCD domain; Region: FCD; pfam07729
438753008680	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
438753008681	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
438753008682	molybdopterin cofactor binding site [chemical binding]; other site
438753008683	substrate binding site [chemical binding]; other site
438753008684	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
438753008685	molybdopterin cofactor binding site; other site
438753008686	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
438753008687	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
438753008688	dimer interface [polypeptide binding]; other site
438753008689	active site
438753008690	catalytic residue [active]
438753008691	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
438753008692	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
438753008693	putative NAD(P) binding site [chemical binding]; other site
438753008694	putative active site [active]
438753008695	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753008696	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008697	dimer interface [polypeptide binding]; other site
438753008698	conserved gate region; other site
438753008699	putative PBP binding loops; other site
438753008700	ABC-ATPase subunit interface; other site
438753008701	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
438753008702	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
438753008703	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008704	dimer interface [polypeptide binding]; other site
438753008705	conserved gate region; other site
438753008706	putative PBP binding loops; other site
438753008707	ABC-ATPase subunit interface; other site
438753008708	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753008709	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
438753008710	Walker A/P-loop; other site
438753008711	ATP binding site [chemical binding]; other site
438753008712	Q-loop/lid; other site
438753008713	ABC transporter signature motif; other site
438753008714	Walker B; other site
438753008715	D-loop; other site
438753008716	H-loop/switch region; other site
438753008717	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
438753008718	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753008719	ABC transporter; Region: ABC_tran; pfam00005
438753008720	Q-loop/lid; other site
438753008721	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
438753008722	ABC transporter signature motif; other site
438753008723	Walker B; other site
438753008724	D-loop; other site
438753008725	H-loop/switch region; other site
438753008726	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753008727	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753008728	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
438753008729	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
438753008730	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
438753008731	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
438753008732	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753008733	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753008734	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
438753008735	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
438753008736	active site
438753008737	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753008738	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
438753008739	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753008740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008741	dimer interface [polypeptide binding]; other site
438753008742	conserved gate region; other site
438753008743	putative PBP binding loops; other site
438753008744	ABC-ATPase subunit interface; other site
438753008745	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
438753008746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008747	dimer interface [polypeptide binding]; other site
438753008748	conserved gate region; other site
438753008749	putative PBP binding loops; other site
438753008750	ABC-ATPase subunit interface; other site
438753008751	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
438753008752	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753008753	Walker A/P-loop; other site
438753008754	ATP binding site [chemical binding]; other site
438753008755	Q-loop/lid; other site
438753008756	ABC transporter signature motif; other site
438753008757	Walker B; other site
438753008758	D-loop; other site
438753008759	H-loop/switch region; other site
438753008760	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753008761	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
438753008762	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753008763	Walker A/P-loop; other site
438753008764	ATP binding site [chemical binding]; other site
438753008765	Q-loop/lid; other site
438753008766	ABC transporter signature motif; other site
438753008767	Walker B; other site
438753008768	D-loop; other site
438753008769	H-loop/switch region; other site
438753008770	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
438753008771	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
438753008772	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
438753008773	active site
438753008774	catalytic tetrad [active]
438753008775	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
438753008776	active site
438753008777	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
438753008778	dimer interface [polypeptide binding]; other site
438753008779	non-prolyl cis peptide bond; other site
438753008780	insertion regions; other site
438753008781	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
438753008782	active site
438753008783	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
438753008784	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
438753008785	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
438753008786	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753008787	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753008788	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
438753008789	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753008790	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753008791	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
438753008792	putative effector binding pocket; other site
438753008793	putative dimerization interface [polypeptide binding]; other site
438753008794	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753008795	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753008796	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
438753008797	putative dimerization interface [polypeptide binding]; other site
438753008798	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
438753008799	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
438753008800	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
438753008801	dihydropyrimidinase; Provisional; Region: PRK13404
438753008802	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
438753008803	tetramer interface [polypeptide binding]; other site
438753008804	active site
438753008805	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753008806	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753008807	DNA-binding site [nucleotide binding]; DNA binding site
438753008808	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
438753008809	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
438753008810	DNA-binding site [nucleotide binding]; DNA binding site
438753008811	RNA-binding motif; other site
438753008812	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
438753008813	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753008814	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753008815	Walker A/P-loop; other site
438753008816	ATP binding site [chemical binding]; other site
438753008817	Q-loop/lid; other site
438753008818	ABC transporter signature motif; other site
438753008819	Walker B; other site
438753008820	D-loop; other site
438753008821	H-loop/switch region; other site
438753008822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008823	dimer interface [polypeptide binding]; other site
438753008824	conserved gate region; other site
438753008825	putative PBP binding loops; other site
438753008826	ABC-ATPase subunit interface; other site
438753008827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008828	dimer interface [polypeptide binding]; other site
438753008829	conserved gate region; other site
438753008830	putative PBP binding loops; other site
438753008831	ABC-ATPase subunit interface; other site
438753008832	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753008833	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753008834	substrate binding pocket [chemical binding]; other site
438753008835	membrane-bound complex binding site; other site
438753008836	hinge residues; other site
438753008837	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
438753008838	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
438753008839	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
438753008840	hydroxyglutarate oxidase; Provisional; Region: PRK11728
438753008841	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
438753008842	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
438753008843	inhibitor site; inhibition site
438753008844	active site
438753008845	dimer interface [polypeptide binding]; other site
438753008846	catalytic residue [active]
438753008847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
438753008848	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
438753008849	Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207
438753008850	dimer interface [polypeptide binding]; other site
438753008851	active site
438753008852	catalytic residue [active]
438753008853	metal binding site [ion binding]; metal-binding site
438753008854	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
438753008855	dimer interface [polypeptide binding]; other site
438753008856	substrate binding site [chemical binding]; other site
438753008857	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753008858	metal binding site [ion binding]; metal-binding site
438753008859	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
438753008860	DctM-like transporters; Region: DctM; pfam06808
438753008861	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
438753008862	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
438753008863	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
438753008864	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
438753008865	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
438753008866	DNA binding site [nucleotide binding]
438753008867	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
438753008868	putative ligand binding site [chemical binding]; other site
438753008869	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
438753008870	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
438753008871	inhibitor site; inhibition site
438753008872	active site
438753008873	dimer interface [polypeptide binding]; other site
438753008874	catalytic residue [active]
438753008875	amidase; Provisional; Region: PRK07042
438753008876	Amidase; Region: Amidase; cl11426
438753008877	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
438753008878	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753008879	Walker A/P-loop; other site
438753008880	ATP binding site [chemical binding]; other site
438753008881	Q-loop/lid; other site
438753008882	ABC transporter signature motif; other site
438753008883	Walker B; other site
438753008884	D-loop; other site
438753008885	H-loop/switch region; other site
438753008886	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753008887	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
438753008888	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753008889	Walker A/P-loop; other site
438753008890	ATP binding site [chemical binding]; other site
438753008891	Q-loop/lid; other site
438753008892	ABC transporter signature motif; other site
438753008893	Walker B; other site
438753008894	D-loop; other site
438753008895	H-loop/switch region; other site
438753008896	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753008897	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
438753008898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008899	dimer interface [polypeptide binding]; other site
438753008900	conserved gate region; other site
438753008901	putative PBP binding loops; other site
438753008902	ABC-ATPase subunit interface; other site
438753008903	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753008904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008905	dimer interface [polypeptide binding]; other site
438753008906	conserved gate region; other site
438753008907	putative PBP binding loops; other site
438753008908	ABC-ATPase subunit interface; other site
438753008909	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753008910	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
438753008911	flagellin; Reviewed; Region: PRK12687
438753008912	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
438753008913	Isochorismatase family; Region: Isochorismatase; pfam00857
438753008914	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
438753008915	catalytic triad [active]
438753008916	conserved cis-peptide bond; other site
438753008917	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
438753008918	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
438753008919	conserved cys residue [active]
438753008920	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753008921	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
438753008922	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
438753008923	N-terminal plug; other site
438753008924	ligand-binding site [chemical binding]; other site
438753008925	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
438753008926	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
438753008927	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
438753008928	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
438753008929	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
438753008930	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
438753008931	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
438753008932	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753008933	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
438753008934	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753008935	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
438753008936	Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954
438753008937	NodB motif; other site
438753008938	active site
438753008939	catalytic site [active]
438753008940	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
438753008941	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
438753008942	active site
438753008943	ATP binding site [chemical binding]; other site
438753008944	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
438753008945	glycerol kinase; Provisional; Region: glpK; PRK00047
438753008946	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
438753008947	N- and C-terminal domain interface [polypeptide binding]; other site
438753008948	active site
438753008949	MgATP binding site [chemical binding]; other site
438753008950	catalytic site [active]
438753008951	metal binding site [ion binding]; metal-binding site
438753008952	putative homotetramer interface [polypeptide binding]; other site
438753008953	glycerol binding site [chemical binding]; other site
438753008954	homodimer interface [polypeptide binding]; other site
438753008955	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
438753008956	amphipathic channel; other site
438753008957	Asn-Pro-Ala signature motifs; other site
438753008958	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753008959	dimerization interface [polypeptide binding]; other site
438753008960	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753008961	dimer interface [polypeptide binding]; other site
438753008962	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
438753008963	putative CheW interface [polypeptide binding]; other site
438753008964	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
438753008965	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
438753008966	active site
438753008967	dimer interface [polypeptide binding]; other site
438753008968	non-prolyl cis peptide bond; other site
438753008969	insertion regions; other site
438753008970	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
438753008971	NMT1-like family; Region: NMT1_2; pfam13379
438753008972	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753008973	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753008974	Walker A/P-loop; other site
438753008975	ATP binding site [chemical binding]; other site
438753008976	Q-loop/lid; other site
438753008977	ABC transporter signature motif; other site
438753008978	Walker B; other site
438753008979	D-loop; other site
438753008980	H-loop/switch region; other site
438753008981	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753008982	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753008983	dimer interface [polypeptide binding]; other site
438753008984	ABC-ATPase subunit interface; other site
438753008985	putative PBP binding loops; other site
438753008986	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753008987	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753008988	metal binding site [ion binding]; metal-binding site
438753008989	active site
438753008990	I-site; other site
438753008991	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
438753008992	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
438753008993	TrkA-N domain; Region: TrkA_N; pfam02254
438753008994	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
438753008995	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
438753008996	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
438753008997	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
438753008998	Transcriptional regulator [Transcription]; Region: IclR; COG1414
438753008999	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753009000	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
438753009001	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753009002	dimer interface [polypeptide binding]; other site
438753009003	conserved gate region; other site
438753009004	putative PBP binding loops; other site
438753009005	ABC-ATPase subunit interface; other site
438753009006	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
438753009007	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753009008	dimer interface [polypeptide binding]; other site
438753009009	conserved gate region; other site
438753009010	putative PBP binding loops; other site
438753009011	ABC-ATPase subunit interface; other site
438753009012	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
438753009013	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
438753009014	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
438753009015	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
438753009016	Walker A/P-loop; other site
438753009017	ATP binding site [chemical binding]; other site
438753009018	Q-loop/lid; other site
438753009019	ABC transporter signature motif; other site
438753009020	Walker B; other site
438753009021	D-loop; other site
438753009022	H-loop/switch region; other site
438753009023	TOBE domain; Region: TOBE_2; pfam08402
438753009024	hypothetical protein; Provisional; Region: PRK10481
438753009025	Protein of unknown function (DUF917); Region: DUF917; pfam06032
438753009026	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
438753009027	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
438753009028	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
438753009029	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
438753009030	putative deacylase active site [active]
438753009031	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
438753009032	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753009033	active site
438753009034	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753009035	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753009036	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753009037	dimerization interface [polypeptide binding]; other site
438753009038	N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569
438753009039	Predicted amidohydrolase [General function prediction only]; Region: COG0388
438753009040	tetramer interface [polypeptide binding]; other site
438753009041	active site
438753009042	catalytic triad [active]
438753009043	dimer interface [polypeptide binding]; other site
438753009044	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753009045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753009046	dimer interface [polypeptide binding]; other site
438753009047	conserved gate region; other site
438753009048	putative PBP binding loops; other site
438753009049	ABC-ATPase subunit interface; other site
438753009050	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753009051	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753009052	Walker A/P-loop; other site
438753009053	ATP binding site [chemical binding]; other site
438753009054	Q-loop/lid; other site
438753009055	ABC transporter signature motif; other site
438753009056	Walker B; other site
438753009057	D-loop; other site
438753009058	H-loop/switch region; other site
438753009059	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753009060	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753009061	substrate binding pocket [chemical binding]; other site
438753009062	membrane-bound complex binding site; other site
438753009063	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
438753009064	active site
438753009065	catalytic site [active]
438753009066	Zn binding site [ion binding]; other site
438753009067	tetramer interface [polypeptide binding]; other site
438753009068	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
438753009069	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
438753009070	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
438753009071	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
438753009072	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
438753009073	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
438753009074	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753009075	dimerization interface [polypeptide binding]; other site
438753009076	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753009077	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753009078	dimer interface [polypeptide binding]; other site
438753009079	putative CheW interface [polypeptide binding]; other site
438753009080	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
438753009081	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
438753009082	conserved cys residue [active]
438753009083	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753009084	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
438753009085	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
438753009086	conserved cys residue [active]
438753009087	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
438753009088	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
438753009089	Iron permease FTR1 family; Region: FTR1; cl00475
438753009090	Imelysin; Region: Peptidase_M75; cl09159
438753009091	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
438753009092	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
438753009093	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
438753009094	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
438753009095	Imelysin; Region: Peptidase_M75; cl09159
438753009096	Protein of unknown function (DUF1513); Region: DUF1513; pfam07433
438753009097	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
438753009098	active site
438753009099	catalytic nucleophile [active]
438753009100	dimer interface [polypeptide binding]; other site
438753009101	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
438753009102	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
438753009103	active site
438753009104	Zn binding site [ion binding]; other site
438753009105	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
438753009106	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
438753009107	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
438753009108	active site
438753009109	catalytic site [active]
438753009110	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
438753009111	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
438753009112	FAD binding pocket [chemical binding]; other site
438753009113	FAD binding motif [chemical binding]; other site
438753009114	phosphate binding motif [ion binding]; other site
438753009115	beta-alpha-beta structure motif; other site
438753009116	NAD binding pocket [chemical binding]; other site
438753009117	Heme binding  pocket [chemical binding]; other site
438753009118	PAS domain S-box; Region: sensory_box; TIGR00229
438753009119	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753009120	putative active site [active]
438753009121	heme pocket [chemical binding]; other site
438753009122	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753009123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753009124	active site
438753009125	phosphorylation site [posttranslational modification]
438753009126	intermolecular recognition site; other site
438753009127	dimerization interface [polypeptide binding]; other site
438753009128	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753009129	DNA binding site [nucleotide binding]
438753009130	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
438753009131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753009132	ATP binding site [chemical binding]; other site
438753009133	Mg2+ binding site [ion binding]; other site
438753009134	G-X-G motif; other site
438753009135	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
438753009136	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
438753009137	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753009138	Walker A/P-loop; other site
438753009139	ATP binding site [chemical binding]; other site
438753009140	Q-loop/lid; other site
438753009141	ABC transporter signature motif; other site
438753009142	Walker B; other site
438753009143	D-loop; other site
438753009144	H-loop/switch region; other site
438753009145	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
438753009146	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753009147	putative ADP-binding pocket [chemical binding]; other site
438753009148	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753009149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753009150	putative substrate translocation pore; other site
438753009151	PRC-barrel domain; Region: PRC; pfam05239
438753009152	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
438753009153	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
438753009154	pyruvate phosphate dikinase; Provisional; Region: PRK09279
438753009155	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
438753009156	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
438753009157	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
438753009158	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753009159	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753009160	metal binding site [ion binding]; metal-binding site
438753009161	active site
438753009162	I-site; other site
438753009163	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
438753009164	active site clefts [active]
438753009165	zinc binding site [ion binding]; other site
438753009166	dimer interface [polypeptide binding]; other site
438753009167	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753009168	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753009169	DNA-binding site [nucleotide binding]; DNA binding site
438753009170	FCD domain; Region: FCD; pfam07729
438753009171	mannonate dehydratase; Provisional; Region: PRK03906
438753009172	mannonate dehydratase; Region: uxuA; TIGR00695
438753009173	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
438753009174	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
438753009175	NAD binding site [chemical binding]; other site
438753009176	homotetramer interface [polypeptide binding]; other site
438753009177	homodimer interface [polypeptide binding]; other site
438753009178	substrate binding site [chemical binding]; other site
438753009179	active site
438753009180	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
438753009181	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
438753009182	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
438753009183	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
438753009184	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
438753009185	acyl-activating enzyme (AAE) consensus motif; other site
438753009186	AMP binding site [chemical binding]; other site
438753009187	active site
438753009188	CoA binding site [chemical binding]; other site
438753009189	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
438753009190	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753009191	putative DNA binding site [nucleotide binding]; other site
438753009192	putative Zn2+ binding site [ion binding]; other site
438753009193	AsnC family; Region: AsnC_trans_reg; pfam01037
438753009194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
438753009195	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
438753009196	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
438753009197	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
438753009198	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
438753009199	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
438753009200	DNA binding site [nucleotide binding]
438753009201	domain linker motif; other site
438753009202	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
438753009203	putative dimerization interface [polypeptide binding]; other site
438753009204	putative ligand binding site [chemical binding]; other site
438753009205	putative aldolase; Validated; Region: PRK08130
438753009206	intersubunit interface [polypeptide binding]; other site
438753009207	active site
438753009208	Zn2+ binding site [ion binding]; other site
438753009209	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
438753009210	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
438753009211	active site
438753009212	catalytic tetrad [active]
438753009213	Uncharacterized conserved protein [Function unknown]; Region: COG1359
438753009214	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
438753009215	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
438753009216	potential catalytic triad [active]
438753009217	conserved cys residue [active]
438753009218	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
438753009219	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753009220	The C-terminal substrate binding of LysR-type symbiotic regulator SyrM, which activates expression of nodulation gene NodD3, contains the type 2 periplasmic binding fold; Region: PBP2_SyrM; cd08467
438753009221	putative substrate binding pocket [chemical binding]; other site
438753009222	putative dimerization interface [polypeptide binding]; other site
438753009223	Uncharacterized conserved protein [Function unknown]; Region: COG5361
438753009224	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
438753009225	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
438753009226	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
438753009227	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
438753009228	FMN-binding pocket [chemical binding]; other site
438753009229	flavin binding motif; other site
438753009230	phosphate binding motif [ion binding]; other site
438753009231	beta-alpha-beta structure motif; other site
438753009232	NAD binding pocket [chemical binding]; other site
438753009233	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753009234	catalytic loop [active]
438753009235	iron binding site [ion binding]; other site
438753009236	MOSC domain; Region: MOSC; pfam03473
438753009237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753009238	metabolite-proton symporter; Region: 2A0106; TIGR00883
438753009239	putative substrate translocation pore; other site
438753009240	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
438753009241	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753009242	non-specific DNA binding site [nucleotide binding]; other site
438753009243	salt bridge; other site
438753009244	sequence-specific DNA binding site [nucleotide binding]; other site
438753009245	Cupin domain; Region: Cupin_2; pfam07883
438753009246	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
438753009247	MarR family; Region: MarR_2; pfam12802
438753009248	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753009249	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753009250	Walker A/P-loop; other site
438753009251	ATP binding site [chemical binding]; other site
438753009252	Q-loop/lid; other site
438753009253	ABC transporter signature motif; other site
438753009254	Walker B; other site
438753009255	D-loop; other site
438753009256	H-loop/switch region; other site
438753009257	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753009258	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753009259	Walker A/P-loop; other site
438753009260	ATP binding site [chemical binding]; other site
438753009261	Q-loop/lid; other site
438753009262	ABC transporter signature motif; other site
438753009263	Walker B; other site
438753009264	D-loop; other site
438753009265	H-loop/switch region; other site
438753009266	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753009267	TM-ABC transporter signature motif; other site
438753009268	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753009269	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753009270	TM-ABC transporter signature motif; other site
438753009271	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753009272	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
438753009273	putative ligand binding site [chemical binding]; other site
438753009274	Amino acid synthesis; Region: AA_synth; pfam06684
438753009275	Amino acid synthesis; Region: AA_synth; pfam06684
438753009276	hypothetical protein; Provisional; Region: PRK04334
438753009277	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
438753009278	CoA-transferase family III; Region: CoA_transf_3; pfam02515
438753009279	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
438753009280	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753009281	catalytic loop [active]
438753009282	iron binding site [ion binding]; other site
438753009283	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
438753009284	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753009285	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
438753009286	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
438753009287	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753009288	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
438753009289	Cytochrome c; Region: Cytochrom_C; pfam00034
438753009290	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
438753009291	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
438753009292	4Fe-4S binding domain; Region: Fer4; cl02805
438753009293	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
438753009294	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
438753009295	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
438753009296	FAD binding pocket [chemical binding]; other site
438753009297	FAD binding motif [chemical binding]; other site
438753009298	phosphate binding motif [ion binding]; other site
438753009299	beta-alpha-beta structure motif; other site
438753009300	NAD binding pocket [chemical binding]; other site
438753009301	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
438753009302	Amidohydrolase; Region: Amidohydro_5; pfam13594
438753009303	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
438753009304	active site
438753009305	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753009306	Sporulation related domain; Region: SPOR; pfam05036
438753009307	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
438753009308	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
438753009309	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
438753009310	active site
438753009311	HIGH motif; other site
438753009312	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
438753009313	KMSK motif region; other site
438753009314	tRNA binding surface [nucleotide binding]; other site
438753009315	DALR anticodon binding domain; Region: DALR_1; smart00836
438753009316	anticodon binding site; other site
438753009317	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
438753009318	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
438753009319	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
438753009320	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
438753009321	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
438753009322	putative catalytic site [active]
438753009323	putative phosphate binding site [ion binding]; other site
438753009324	active site
438753009325	metal binding site A [ion binding]; metal-binding site
438753009326	DNA binding site [nucleotide binding]
438753009327	putative AP binding site [nucleotide binding]; other site
438753009328	putative metal binding site B [ion binding]; other site
438753009329	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
438753009330	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
438753009331	Sel1-like repeats; Region: SEL1; smart00671
438753009332	Sel1-like repeats; Region: SEL1; smart00671
438753009333	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
438753009334	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
438753009335	HIGH motif; other site
438753009336	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
438753009337	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
438753009338	active site
438753009339	KMSKS motif; other site
438753009340	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
438753009341	tRNA binding surface [nucleotide binding]; other site
438753009342	anticodon binding site; other site
438753009343	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
438753009344	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
438753009345	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
438753009346	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
438753009347	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
438753009348	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
438753009349	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
438753009350	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
438753009351	Walker A/P-loop; other site
438753009352	ATP binding site [chemical binding]; other site
438753009353	Q-loop/lid; other site
438753009354	ABC transporter signature motif; other site
438753009355	Walker B; other site
438753009356	D-loop; other site
438753009357	H-loop/switch region; other site
438753009358	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
438753009359	DNA photolyase; Region: DNA_photolyase; pfam00875
438753009360	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
438753009361	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
438753009362	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
438753009363	dimer interface [polypeptide binding]; other site
438753009364	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753009365	catalytic residue [active]
438753009366	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
438753009367	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
438753009368	active site residue [active]
438753009369	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
438753009370	active site residue [active]
438753009371	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
438753009372	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753009373	dimerization interface [polypeptide binding]; other site
438753009374	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753009375	dimer interface [polypeptide binding]; other site
438753009376	putative CheW interface [polypeptide binding]; other site
438753009377	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753009378	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753009379	dimer interface [polypeptide binding]; other site
438753009380	putative CheW interface [polypeptide binding]; other site
438753009381	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
438753009382	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
438753009383	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
438753009384	putative C-terminal domain interface [polypeptide binding]; other site
438753009385	putative GSH binding site (G-site) [chemical binding]; other site
438753009386	putative dimer interface [polypeptide binding]; other site
438753009387	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
438753009388	putative N-terminal domain interface [polypeptide binding]; other site
438753009389	putative dimer interface [polypeptide binding]; other site
438753009390	putative substrate binding pocket (H-site) [chemical binding]; other site
438753009391	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
438753009392	Uncharacterized conserved protein [Function unknown]; Region: COG1434
438753009393	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
438753009394	putative active site [active]
438753009395	isovaleryl-CoA dehydrogenase; Region: PLN02519
438753009396	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
438753009397	substrate binding site [chemical binding]; other site
438753009398	FAD binding site [chemical binding]; other site
438753009399	catalytic base [active]
438753009400	CHASE4 domain; Region: CHASE4; cl01308
438753009401	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753009402	metal binding site [ion binding]; metal-binding site
438753009403	active site
438753009404	I-site; other site
438753009405	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753009406	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
438753009407	MgtE intracellular N domain; Region: MgtE_N; smart00924
438753009408	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
438753009409	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
438753009410	Divalent cation transporter; Region: MgtE; cl00786
438753009411	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
438753009412	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
438753009413	NodB motif; other site
438753009414	active site
438753009415	catalytic site [active]
438753009416	metal binding site [ion binding]; metal-binding site
438753009417	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
438753009418	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
438753009419	NodB motif; other site
438753009420	active site
438753009421	catalytic site [active]
438753009422	metal binding site [ion binding]; metal-binding site
438753009423	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
438753009424	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753009425	Coenzyme A binding pocket [chemical binding]; other site
438753009426	lipoate-protein ligase B; Provisional; Region: PRK14341
438753009427	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
438753009428	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
438753009429	metal-dependent hydrolase; Provisional; Region: PRK00685
438753009430	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
438753009431	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
438753009432	ATP binding site [chemical binding]; other site
438753009433	putative Mg++ binding site [ion binding]; other site
438753009434	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
438753009435	nucleotide binding region [chemical binding]; other site
438753009436	ATP-binding site [chemical binding]; other site
438753009437	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
438753009438	HRDC domain; Region: HRDC; pfam00570
438753009439	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
438753009440	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753009441	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
438753009442	Chorismate mutase type II; Region: CM_2; smart00830
438753009443	active site
438753009444	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
438753009445	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
438753009446	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
438753009447	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
438753009448	GatB domain; Region: GatB_Yqey; smart00845
438753009449	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
438753009450	DNA protecting protein DprA; Region: dprA; TIGR00732
438753009451	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
438753009452	dihydroorotase; Validated; Region: PRK09059
438753009453	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753009454	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
438753009455	active site
438753009456	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
438753009457	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
438753009458	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
438753009459	Membrane transport protein; Region: Mem_trans; cl09117
438753009460	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
438753009461	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
438753009462	motif 1; other site
438753009463	active site
438753009464	motif 2; other site
438753009465	motif 3; other site
438753009466	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
438753009467	recombinase A; Provisional; Region: recA; PRK09354
438753009468	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
438753009469	hexamer interface [polypeptide binding]; other site
438753009470	Walker A motif; other site
438753009471	ATP binding site [chemical binding]; other site
438753009472	Walker B motif; other site
438753009473	Transcriptional regulators [Transcription]; Region: PurR; COG1609
438753009474	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
438753009475	DNA binding site [nucleotide binding]
438753009476	domain linker motif; other site
438753009477	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285
438753009478	putative dimerization interface [polypeptide binding]; other site
438753009479	putative ligand binding site [chemical binding]; other site
438753009480	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
438753009481	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
438753009482	inhibitor site; inhibition site
438753009483	active site
438753009484	dimer interface [polypeptide binding]; other site
438753009485	catalytic residue [active]
438753009486	benzoate transport; Region: 2A0115; TIGR00895
438753009487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753009488	putative substrate translocation pore; other site
438753009489	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753009490	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
438753009491	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
438753009492	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753009493	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
438753009494	Uncharacterized conserved protein [Function unknown]; Region: COG1262
438753009495	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
438753009496	Sulfatase; Region: Sulfatase; pfam00884
438753009497	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
438753009498	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
438753009499	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
438753009500	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
438753009501	catalytic residue [active]
438753009502	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
438753009503	CoA-transferase family III; Region: CoA_transf_3; pfam02515
438753009504	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
438753009505	Transcriptional regulator [Transcription]; Region: IclR; COG1414
438753009506	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753009507	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
438753009508	substrate binding site [chemical binding]; other site
438753009509	oxyanion hole (OAH) forming residues; other site
438753009510	trimer interface [polypeptide binding]; other site
438753009511	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
438753009512	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
438753009513	FMN binding site [chemical binding]; other site
438753009514	substrate binding site [chemical binding]; other site
438753009515	putative catalytic residue [active]
438753009516	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753009517	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753009518	Walker A/P-loop; other site
438753009519	ATP binding site [chemical binding]; other site
438753009520	Q-loop/lid; other site
438753009521	ABC transporter signature motif; other site
438753009522	Walker B; other site
438753009523	D-loop; other site
438753009524	H-loop/switch region; other site
438753009525	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753009526	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753009527	Walker A/P-loop; other site
438753009528	ATP binding site [chemical binding]; other site
438753009529	Q-loop/lid; other site
438753009530	ABC transporter signature motif; other site
438753009531	Walker B; other site
438753009532	D-loop; other site
438753009533	H-loop/switch region; other site
438753009534	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753009535	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753009536	TM-ABC transporter signature motif; other site
438753009537	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753009538	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753009539	TM-ABC transporter signature motif; other site
438753009540	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
438753009541	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
438753009542	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
438753009543	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
438753009544	substrate binding site [chemical binding]; other site
438753009545	oxyanion hole (OAH) forming residues; other site
438753009546	trimer interface [polypeptide binding]; other site
438753009547	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
438753009548	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
438753009549	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
438753009550	dicarboxylate--CoA ligase PimA; Region: pimA; TIGR03205
438753009551	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
438753009552	acyl-activating enzyme (AAE) consensus motif; other site
438753009553	AMP binding site [chemical binding]; other site
438753009554	active site
438753009555	CoA binding site [chemical binding]; other site
438753009556	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
438753009557	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
438753009558	dimer interface [polypeptide binding]; other site
438753009559	active site
438753009560	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
438753009561	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
438753009562	active site
438753009563	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
438753009564	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
438753009565	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
438753009566	active site
438753009567	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
438753009568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753009569	putative substrate translocation pore; other site
438753009570	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753009571	metabolite-proton symporter; Region: 2A0106; TIGR00883
438753009572	putative substrate translocation pore; other site
438753009573	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
438753009574	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
438753009575	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
438753009576	active site
438753009577	Fe binding site [ion binding]; other site
438753009578	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
438753009579	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
438753009580	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
438753009581	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
438753009582	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
438753009583	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
438753009584	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753009585	putative DNA binding site [nucleotide binding]; other site
438753009586	putative Zn2+ binding site [ion binding]; other site
438753009587	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753009588	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753009589	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753009590	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
438753009591	Autotransporter beta-domain; Region: Autotransporter; smart00869
438753009592	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
438753009593	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
438753009594	dimer interface [polypeptide binding]; other site
438753009595	ssDNA binding site [nucleotide binding]; other site
438753009596	tetramer (dimer of dimers) interface [polypeptide binding]; other site
438753009597	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
438753009598	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
438753009599	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
438753009600	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
438753009601	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
438753009602	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
438753009603	Glucose inhibited division protein A; Region: GIDA; pfam01134
438753009604	serine/threonine protein kinase; Provisional; Region: PRK09188
438753009605	serine/threonine protein kinase; Provisional; Region: PRK12274
438753009606	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
438753009607	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
438753009608	substrate binding pocket [chemical binding]; other site
438753009609	substrate-Mg2+ binding site; other site
438753009610	aspartate-rich region 1; other site
438753009611	aspartate-rich region 2; other site
438753009612	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
438753009613	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
438753009614	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
438753009615	Protein export membrane protein; Region: SecD_SecF; pfam02355
438753009616	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
438753009617	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
438753009618	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
438753009619	Preprotein translocase subunit; Region: YajC; pfam02699
438753009620	cobalamin synthase; Reviewed; Region: cobS; PRK00235
438753009621	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
438753009622	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
438753009623	Predicted aspartyl protease [General function prediction only]; Region: COG3577
438753009624	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
438753009625	catalytic motif [active]
438753009626	Catalytic residue [active]
438753009627	Cation efflux family; Region: Cation_efflux; pfam01545
438753009628	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
438753009629	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
438753009630	active site
438753009631	catalytic tetrad [active]
438753009632	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
438753009633	aromatic chitin/cellulose binding site residues [chemical binding]; other site
438753009634	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
438753009635	Interdomain contacts; other site
438753009636	Cytokine receptor motif; other site
438753009637	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
438753009638	active site
438753009639	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753009640	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753009641	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
438753009642	dimerization interface [polypeptide binding]; other site
438753009643	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
438753009644	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
438753009645	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
438753009646	NAD(P) binding site [chemical binding]; other site
438753009647	catalytic residues [active]
438753009648	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
438753009649	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
438753009650	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753009651	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753009652	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753009653	dimerization interface [polypeptide binding]; other site
438753009654	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
438753009655	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753009656	Walker A/P-loop; other site
438753009657	ATP binding site [chemical binding]; other site
438753009658	Q-loop/lid; other site
438753009659	ABC transporter signature motif; other site
438753009660	Walker B; other site
438753009661	D-loop; other site
438753009662	H-loop/switch region; other site
438753009663	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753009664	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
438753009665	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753009666	Walker A/P-loop; other site
438753009667	ATP binding site [chemical binding]; other site
438753009668	Q-loop/lid; other site
438753009669	ABC transporter signature motif; other site
438753009670	Walker B; other site
438753009671	D-loop; other site
438753009672	H-loop/switch region; other site
438753009673	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
438753009674	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
438753009675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753009676	dimer interface [polypeptide binding]; other site
438753009677	conserved gate region; other site
438753009678	putative PBP binding loops; other site
438753009679	ABC-ATPase subunit interface; other site
438753009680	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753009681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753009682	dimer interface [polypeptide binding]; other site
438753009683	conserved gate region; other site
438753009684	putative PBP binding loops; other site
438753009685	ABC-ATPase subunit interface; other site
438753009686	Creatinine amidohydrolase; Region: Creatininase; pfam02633
438753009687	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
438753009688	MarR family; Region: MarR_2; pfam12802
438753009689	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
438753009690	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
438753009691	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
438753009692	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635
438753009693	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753009694	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
438753009695	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753009696	binding surface
438753009697	TPR motif; other site
438753009698	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753009699	binding surface
438753009700	TPR motif; other site
438753009701	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
438753009702	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
438753009703	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
438753009704	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
438753009705	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
438753009706	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
438753009707	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
438753009708	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
438753009709	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
438753009710	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753009711	Walker A motif; other site
438753009712	ATP binding site [chemical binding]; other site
438753009713	Walker B motif; other site
438753009714	arginine finger; other site
438753009715	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
438753009716	TPR repeat; Region: TPR_11; pfam13414
438753009717	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753009718	binding surface
438753009719	TPR motif; other site
438753009720	TPR repeat; Region: TPR_11; pfam13414
438753009721	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753009722	binding surface
438753009723	TPR motif; other site
438753009724	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
438753009725	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
438753009726	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
438753009727	C-terminal domain interface [polypeptide binding]; other site
438753009728	GSH binding site (G-site) [chemical binding]; other site
438753009729	dimer interface [polypeptide binding]; other site
438753009730	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
438753009731	N-terminal domain interface [polypeptide binding]; other site
438753009732	putative dimer interface [polypeptide binding]; other site
438753009733	active site
438753009734	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
438753009735	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753009736	FeS/SAM binding site; other site
438753009737	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
438753009738	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
438753009739	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
438753009740	XdhC Rossmann domain; Region: XdhC_C; pfam13478
438753009741	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
438753009742	putative MPT binding site; other site
438753009743	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
438753009744	Ligand binding site; other site
438753009745	metal-binding site
438753009746	major facilitator superfamily transporter; Provisional; Region: PRK05122
438753009747	Protein of unknown function, DUF488; Region: DUF488; pfam04343
438753009748	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
438753009749	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
438753009750	metal ion-dependent adhesion site (MIDAS); other site
438753009751	MoxR-like ATPases [General function prediction only]; Region: COG0714
438753009752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753009753	Walker A motif; other site
438753009754	ATP binding site [chemical binding]; other site
438753009755	Walker B motif; other site
438753009756	arginine finger; other site
438753009757	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
438753009758	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
438753009759	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
438753009760	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
438753009761	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753009762	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
438753009763	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753009764	catalytic loop [active]
438753009765	iron binding site [ion binding]; other site
438753009766	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
438753009767	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
438753009768	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
438753009769	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
438753009770	putative hydrophobic ligand binding site [chemical binding]; other site
438753009771	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753009772	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753009773	TM-ABC transporter signature motif; other site
438753009774	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753009775	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753009776	TM-ABC transporter signature motif; other site
438753009777	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753009778	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753009779	Walker A/P-loop; other site
438753009780	ATP binding site [chemical binding]; other site
438753009781	Q-loop/lid; other site
438753009782	ABC transporter signature motif; other site
438753009783	Walker B; other site
438753009784	D-loop; other site
438753009785	H-loop/switch region; other site
438753009786	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753009787	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753009788	Walker A/P-loop; other site
438753009789	ATP binding site [chemical binding]; other site
438753009790	Q-loop/lid; other site
438753009791	ABC transporter signature motif; other site
438753009792	Walker B; other site
438753009793	D-loop; other site
438753009794	H-loop/switch region; other site
438753009795	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
438753009796	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
438753009797	dimerization interface [polypeptide binding]; other site
438753009798	ligand binding site [chemical binding]; other site
438753009799	Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672
438753009800	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
438753009801	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
438753009802	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
438753009803	putative active site pocket [active]
438753009804	DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603
438753009805	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
438753009806	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
438753009807	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
438753009808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
438753009809	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
438753009810	Subunit III/VIIa interface [polypeptide binding]; other site
438753009811	Phospholipid binding site [chemical binding]; other site
438753009812	Subunit I/III interface [polypeptide binding]; other site
438753009813	Subunit III/VIb interface [polypeptide binding]; other site
438753009814	Subunit III/VIa interface; other site
438753009815	Subunit III/Vb interface [polypeptide binding]; other site
438753009816	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
438753009817	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
438753009818	UbiA prenyltransferase family; Region: UbiA; pfam01040
438753009819	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
438753009820	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
438753009821	Subunit I/III interface [polypeptide binding]; other site
438753009822	D-pathway; other site
438753009823	Subunit I/VIIc interface [polypeptide binding]; other site
438753009824	Subunit I/IV interface [polypeptide binding]; other site
438753009825	Subunit I/II interface [polypeptide binding]; other site
438753009826	Low-spin heme (heme a) binding site [chemical binding]; other site
438753009827	Subunit I/VIIa interface [polypeptide binding]; other site
438753009828	Subunit I/VIa interface [polypeptide binding]; other site
438753009829	Dimer interface; other site
438753009830	Putative water exit pathway; other site
438753009831	Binuclear center (heme a3/CuB) [ion binding]; other site
438753009832	K-pathway; other site
438753009833	Subunit I/Vb interface [polypeptide binding]; other site
438753009834	Putative proton exit pathway; other site
438753009835	Subunit I/VIb interface; other site
438753009836	Subunit I/VIc interface [polypeptide binding]; other site
438753009837	Electron transfer pathway; other site
438753009838	Subunit I/VIIIb interface [polypeptide binding]; other site
438753009839	Subunit I/VIIb interface [polypeptide binding]; other site
438753009840	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
438753009841	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
438753009842	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
438753009843	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
438753009844	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
438753009845	TrkA-N domain; Region: TrkA_N; pfam02254
438753009846	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
438753009847	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
438753009848	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
438753009849	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
438753009850	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753009851	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753009852	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753009853	dimerization interface [polypeptide binding]; other site
438753009854	glutamate--cysteine ligase; Region: PLN02611
438753009855	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
438753009856	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
438753009857	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
438753009858	acyl-activating enzyme (AAE) consensus motif; other site
438753009859	putative AMP binding site [chemical binding]; other site
438753009860	putative active site [active]
438753009861	putative CoA binding site [chemical binding]; other site
438753009862	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
438753009863	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
438753009864	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
438753009865	DNA binding residues [nucleotide binding]
438753009866	putative dimer interface [polypeptide binding]; other site
438753009867	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
438753009868	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
438753009869	dimer interface [polypeptide binding]; other site
438753009870	active site
438753009871	3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545
438753009872	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
438753009873	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
438753009874	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
438753009875	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
438753009876	substrate binding site [chemical binding]; other site
438753009877	oxyanion hole (OAH) forming residues; other site
438753009878	trimer interface [polypeptide binding]; other site
438753009879	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
438753009880	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
438753009881	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
438753009882	active site
438753009883	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
438753009884	SCP-2 sterol transfer family; Region: SCP2; pfam02036
438753009885	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
438753009886	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
438753009887	citrate-proton symporter; Provisional; Region: PRK15075
438753009888	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753009889	putative substrate translocation pore; other site
438753009890	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753009891	dimerization interface [polypeptide binding]; other site
438753009892	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753009893	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753009894	dimer interface [polypeptide binding]; other site
438753009895	putative CheW interface [polypeptide binding]; other site
438753009896	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
438753009897	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
438753009898	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
438753009899	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
438753009900	Soluble P-type ATPase [General function prediction only]; Region: COG4087
438753009901	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
438753009902	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
438753009903	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
438753009904	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
438753009905	dimer interface [polypeptide binding]; other site
438753009906	active site
438753009907	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
438753009908	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
438753009909	Walker A/P-loop; other site
438753009910	ATP binding site [chemical binding]; other site
438753009911	Q-loop/lid; other site
438753009912	ABC transporter signature motif; other site
438753009913	Walker B; other site
438753009914	D-loop; other site
438753009915	H-loop/switch region; other site
438753009916	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
438753009917	FtsX-like permease family; Region: FtsX; pfam02687
438753009918	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
438753009919	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
438753009920	active site
438753009921	catalytic tetrad [active]
438753009922	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
438753009923	catalytic nucleophile [active]
438753009924	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
438753009925	SxDxEG motif; other site
438753009926	active site
438753009927	metal binding site [ion binding]; metal-binding site
438753009928	homopentamer interface [polypeptide binding]; other site
438753009929	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
438753009930	homodimer interface [polypeptide binding]; other site
438753009931	homotetramer interface [polypeptide binding]; other site
438753009932	active site pocket [active]
438753009933	cleavage site
438753009934	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
438753009935	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
438753009936	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753009937	dimer interface [polypeptide binding]; other site
438753009938	ABC-ATPase subunit interface; other site
438753009939	putative PBP binding loops; other site
438753009940	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
438753009941	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753009942	dimer interface [polypeptide binding]; other site
438753009943	conserved gate region; other site
438753009944	putative PBP binding loops; other site
438753009945	ABC-ATPase subunit interface; other site
438753009946	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
438753009947	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
438753009948	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753009949	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
438753009950	Walker A/P-loop; other site
438753009951	ATP binding site [chemical binding]; other site
438753009952	Q-loop/lid; other site
438753009953	ABC transporter signature motif; other site
438753009954	Walker B; other site
438753009955	D-loop; other site
438753009956	H-loop/switch region; other site
438753009957	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
438753009958	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753009959	Walker A/P-loop; other site
438753009960	ATP binding site [chemical binding]; other site
438753009961	Q-loop/lid; other site
438753009962	ABC transporter signature motif; other site
438753009963	Walker B; other site
438753009964	D-loop; other site
438753009965	H-loop/switch region; other site
438753009966	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753009967	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
438753009968	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
438753009969	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
438753009970	putative active site [active]
438753009971	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753009972	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753009973	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753009974	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
438753009975	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
438753009976	active site
438753009977	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753009978	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
438753009979	ligand binding site [chemical binding]; other site
438753009980	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753009981	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753009982	TM-ABC transporter signature motif; other site
438753009983	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753009984	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753009985	TM-ABC transporter signature motif; other site
438753009986	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753009987	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753009988	Walker A/P-loop; other site
438753009989	ATP binding site [chemical binding]; other site
438753009990	Q-loop/lid; other site
438753009991	ABC transporter signature motif; other site
438753009992	Walker B; other site
438753009993	D-loop; other site
438753009994	H-loop/switch region; other site
438753009995	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
438753009996	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753009997	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753009998	Walker A/P-loop; other site
438753009999	ATP binding site [chemical binding]; other site
438753010000	Q-loop/lid; other site
438753010001	ABC transporter signature motif; other site
438753010002	Walker B; other site
438753010003	D-loop; other site
438753010004	H-loop/switch region; other site
438753010005	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
438753010006	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
438753010007	Fe-S cluster binding site [ion binding]; other site
438753010008	active site
438753010009	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
438753010010	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753010011	FeS/SAM binding site; other site
438753010012	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
438753010013	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
438753010014	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
438753010015	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753010016	NAD(P) binding site [chemical binding]; other site
438753010017	active site
438753010018	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753010019	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753010020	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753010021	dimerization interface [polypeptide binding]; other site
438753010022	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
438753010023	ArsC family; Region: ArsC; pfam03960
438753010024	putative catalytic residues [active]
438753010025	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
438753010026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753010027	active site
438753010028	phosphorylation site [posttranslational modification]
438753010029	intermolecular recognition site; other site
438753010030	dimerization interface [polypeptide binding]; other site
438753010031	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753010032	Walker A motif; other site
438753010033	ATP binding site [chemical binding]; other site
438753010034	Walker B motif; other site
438753010035	arginine finger; other site
438753010036	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
438753010037	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
438753010038	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753010039	dimer interface [polypeptide binding]; other site
438753010040	phosphorylation site [posttranslational modification]
438753010041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753010042	ATP binding site [chemical binding]; other site
438753010043	Mg2+ binding site [ion binding]; other site
438753010044	G-X-G motif; other site
438753010045	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
438753010046	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
438753010047	Domain of unknown function (DUF897); Region: DUF897; cl01312
438753010048	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
438753010049	Protein of unknown function (DUF465); Region: DUF465; cl01070
438753010050	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
438753010051	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753010052	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
438753010053	dimerization interface [polypeptide binding]; other site
438753010054	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
438753010055	ornithine decarboxylase; Provisional; Region: PRK13578
438753010056	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
438753010057	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
438753010058	catalytic residue [active]
438753010059	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
438753010060	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
438753010061	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753010062	Coenzyme A binding pocket [chemical binding]; other site
438753010063	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
438753010064	nucleotide binding site [chemical binding]; other site
438753010065	substrate binding site [chemical binding]; other site
438753010066	AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255
438753010067	putative nucleotide binding site [chemical binding]; other site
438753010068	putative substrate binding site [chemical binding]; other site
438753010069	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
438753010070	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
438753010071	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
438753010072	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
438753010073	ligand binding site [chemical binding]; other site
438753010074	NAD binding site [chemical binding]; other site
438753010075	tetramer interface [polypeptide binding]; other site
438753010076	catalytic site [active]
438753010077	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
438753010078	L-serine binding site [chemical binding]; other site
438753010079	ACT domain interface; other site
438753010080	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
438753010081	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
438753010082	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753010083	S-adenosylmethionine binding site [chemical binding]; other site
438753010084	hypothetical protein; Provisional; Region: PRK06489
438753010085	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
438753010086	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
438753010087	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
438753010088	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
438753010089	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753010090	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
438753010091	putative dimerization interface [polypeptide binding]; other site
438753010092	putative substrate binding pocket [chemical binding]; other site
438753010093	Chromate transporter; Region: Chromate_transp; pfam02417
438753010094	Chromate transporter; Region: Chromate_transp; pfam02417
438753010095	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
438753010096	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
438753010097	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
438753010098	Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165
438753010099	active sites [active]
438753010100	tetramer interface [polypeptide binding]; other site
438753010101	Transcriptional regulator [Transcription]; Region: IclR; COG1414
438753010102	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
438753010103	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753010104	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
438753010105	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
438753010106	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
438753010107	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
438753010108	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
438753010109	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753010110	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516
438753010111	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753010112	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753010113	dimer interface [polypeptide binding]; other site
438753010114	conserved gate region; other site
438753010115	putative PBP binding loops; other site
438753010116	ABC-ATPase subunit interface; other site
438753010117	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
438753010118	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753010119	ABC-ATPase subunit interface; other site
438753010120	putative PBP binding loops; other site
438753010121	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
438753010122	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753010123	Walker A/P-loop; other site
438753010124	ATP binding site [chemical binding]; other site
438753010125	Q-loop/lid; other site
438753010126	ABC transporter signature motif; other site
438753010127	Walker B; other site
438753010128	D-loop; other site
438753010129	H-loop/switch region; other site
438753010130	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753010131	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
438753010132	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753010133	Walker A/P-loop; other site
438753010134	ATP binding site [chemical binding]; other site
438753010135	Q-loop/lid; other site
438753010136	ABC transporter signature motif; other site
438753010137	Walker B; other site
438753010138	D-loop; other site
438753010139	H-loop/switch region; other site
438753010140	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
438753010141	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
438753010142	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753010143	NAD(P) binding site [chemical binding]; other site
438753010144	active site
438753010145	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
438753010146	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
438753010147	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
438753010148	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
438753010149	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
438753010150	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
438753010151	conserved cys residue [active]
438753010152	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753010153	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753010154	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
438753010155	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
438753010156	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
438753010157	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
438753010158	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
438753010159	dimer interface [polypeptide binding]; other site
438753010160	active site
438753010161	glycine-pyridoxal phosphate binding site [chemical binding]; other site
438753010162	folate binding site [chemical binding]; other site
438753010163	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
438753010164	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
438753010165	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
438753010166	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
438753010167	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
438753010168	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
438753010169	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
438753010170	Cl binding site [ion binding]; other site
438753010171	oligomer interface [polypeptide binding]; other site
438753010172	hypothetical protein; Validated; Region: PRK09104
438753010173	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
438753010174	metal binding site [ion binding]; metal-binding site
438753010175	putative dimer interface [polypeptide binding]; other site
438753010176	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
438753010177	enolase; Provisional; Region: eno; PRK00077
438753010178	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
438753010179	dimer interface [polypeptide binding]; other site
438753010180	metal binding site [ion binding]; metal-binding site
438753010181	substrate binding pocket [chemical binding]; other site
438753010182	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
438753010183	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
438753010184	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
438753010185	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
438753010186	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
438753010187	CTP synthetase; Validated; Region: pyrG; PRK05380
438753010188	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
438753010189	Catalytic site [active]
438753010190	active site
438753010191	UTP binding site [chemical binding]; other site
438753010192	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
438753010193	active site
438753010194	putative oxyanion hole; other site
438753010195	catalytic triad [active]
438753010196	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
438753010197	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
438753010198	aspartate aminotransferase; Provisional; Region: PRK05764
438753010199	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753010200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753010201	homodimer interface [polypeptide binding]; other site
438753010202	catalytic residue [active]
438753010203	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
438753010204	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
438753010205	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
438753010206	TPR motif; other site
438753010207	binding surface
438753010208	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
438753010209	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
438753010210	catalytic residues [active]
438753010211	Dehydroquinase class II; Region: DHquinase_II; pfam01220
438753010212	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
438753010213	trimer interface [polypeptide binding]; other site
438753010214	active site
438753010215	dimer interface [polypeptide binding]; other site
438753010216	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
438753010217	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
438753010218	carboxyltransferase (CT) interaction site; other site
438753010219	biotinylation site [posttranslational modification]; other site
438753010220	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
438753010221	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
438753010222	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
438753010223	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
438753010224	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753010225	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753010226	Walker A/P-loop; other site
438753010227	ATP binding site [chemical binding]; other site
438753010228	Q-loop/lid; other site
438753010229	ABC transporter signature motif; other site
438753010230	Walker B; other site
438753010231	D-loop; other site
438753010232	H-loop/switch region; other site
438753010233	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
438753010234	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
438753010235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753010236	dimer interface [polypeptide binding]; other site
438753010237	conserved gate region; other site
438753010238	putative PBP binding loops; other site
438753010239	ABC-ATPase subunit interface; other site
438753010240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753010241	dimer interface [polypeptide binding]; other site
438753010242	conserved gate region; other site
438753010243	putative PBP binding loops; other site
438753010244	ABC-ATPase subunit interface; other site
438753010245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753010246	S-adenosylmethionine binding site [chemical binding]; other site
438753010247	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
438753010248	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
438753010249	HflX GTPase family; Region: HflX; cd01878
438753010250	G1 box; other site
438753010251	GTP/Mg2+ binding site [chemical binding]; other site
438753010252	Switch I region; other site
438753010253	G2 box; other site
438753010254	G3 box; other site
438753010255	Switch II region; other site
438753010256	G4 box; other site
438753010257	G5 box; other site
438753010258	bacterial Hfq-like; Region: Hfq; cd01716
438753010259	hexamer interface [polypeptide binding]; other site
438753010260	Sm1 motif; other site
438753010261	RNA binding site [nucleotide binding]; other site
438753010262	Sm2 motif; other site
438753010263	Cation transport protein; Region: TrkH; cl17365
438753010264	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
438753010265	TrkA-N domain; Region: TrkA_N; pfam02254
438753010266	TrkA-C domain; Region: TrkA_C; pfam02080
438753010267	TrkA-N domain; Region: TrkA_N; pfam02254
438753010268	TrkA-C domain; Region: TrkA_C; pfam02080
438753010269	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
438753010270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753010271	active site
438753010272	phosphorylation site [posttranslational modification]
438753010273	intermolecular recognition site; other site
438753010274	dimerization interface [polypeptide binding]; other site
438753010275	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753010276	Walker A motif; other site
438753010277	ATP binding site [chemical binding]; other site
438753010278	Walker B motif; other site
438753010279	arginine finger; other site
438753010280	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
438753010281	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
438753010282	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753010283	dimerization interface [polypeptide binding]; other site
438753010284	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753010285	putative active site [active]
438753010286	heme pocket [chemical binding]; other site
438753010287	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753010288	dimer interface [polypeptide binding]; other site
438753010289	phosphorylation site [posttranslational modification]
438753010290	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753010291	ATP binding site [chemical binding]; other site
438753010292	Mg2+ binding site [ion binding]; other site
438753010293	G-X-G motif; other site
438753010294	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
438753010295	PAS domain S-box; Region: sensory_box; TIGR00229
438753010296	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753010297	putative active site [active]
438753010298	heme pocket [chemical binding]; other site
438753010299	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753010300	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753010301	metal binding site [ion binding]; metal-binding site
438753010302	active site
438753010303	I-site; other site
438753010304	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753010305	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
438753010306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753010307	active site
438753010308	phosphorylation site [posttranslational modification]
438753010309	intermolecular recognition site; other site
438753010310	dimerization interface [polypeptide binding]; other site
438753010311	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753010312	Walker A motif; other site
438753010313	ATP binding site [chemical binding]; other site
438753010314	Walker B motif; other site
438753010315	arginine finger; other site
438753010316	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
438753010317	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
438753010318	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753010319	putative active site [active]
438753010320	heme pocket [chemical binding]; other site
438753010321	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753010322	dimer interface [polypeptide binding]; other site
438753010323	phosphorylation site [posttranslational modification]
438753010324	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753010325	ATP binding site [chemical binding]; other site
438753010326	Mg2+ binding site [ion binding]; other site
438753010327	G-X-G motif; other site
438753010328	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
438753010329	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
438753010330	FMN binding site [chemical binding]; other site
438753010331	active site
438753010332	catalytic residues [active]
438753010333	substrate binding site [chemical binding]; other site
438753010334	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
438753010335	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
438753010336	substrate binding site; other site
438753010337	dimer interface; other site
438753010338	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
438753010339	homotrimer interaction site [polypeptide binding]; other site
438753010340	zinc binding site [ion binding]; other site
438753010341	CDP-binding sites; other site
438753010342	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
438753010343	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
438753010344	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
438753010345	active site
438753010346	DoxX; Region: DoxX; pfam07681
438753010347	Transmembrane secretion effector; Region: MFS_3; pfam05977
438753010348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753010349	putative substrate translocation pore; other site
438753010350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753010351	Response regulator receiver domain; Region: Response_reg; pfam00072
438753010352	active site
438753010353	phosphorylation site [posttranslational modification]
438753010354	intermolecular recognition site; other site
438753010355	dimerization interface [polypeptide binding]; other site
438753010356	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753010357	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753010358	DNA binding site [nucleotide binding]
438753010359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753010360	active site
438753010361	phosphorylation site [posttranslational modification]
438753010362	intermolecular recognition site; other site
438753010363	dimerization interface [polypeptide binding]; other site
438753010364	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753010365	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
438753010366	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753010367	benzoate transport; Region: 2A0115; TIGR00895
438753010368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753010369	putative substrate translocation pore; other site
438753010370	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
438753010371	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
438753010372	substrate binding site [chemical binding]; other site
438753010373	activation loop (A-loop); other site
438753010374	Predicted ATPase [General function prediction only]; Region: COG3899
438753010375	AAA ATPase domain; Region: AAA_16; pfam13191
438753010376	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
438753010377	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
438753010378	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753010379	putative active site [active]
438753010380	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753010381	heme pocket [chemical binding]; other site
438753010382	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753010383	dimer interface [polypeptide binding]; other site
438753010384	phosphorylation site [posttranslational modification]
438753010385	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753010386	ATP binding site [chemical binding]; other site
438753010387	Mg2+ binding site [ion binding]; other site
438753010388	G-X-G motif; other site
438753010389	Protein of unknown function (DUF1427); Region: DUF1427; cl01771
438753010390	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
438753010391	Isochorismatase family; Region: Isochorismatase; pfam00857
438753010392	catalytic triad [active]
438753010393	dimer interface [polypeptide binding]; other site
438753010394	conserved cis-peptide bond; other site
438753010395	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
438753010396	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
438753010397	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
438753010398	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
438753010399	dimerization interface [polypeptide binding]; other site
438753010400	active site
438753010401	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753010402	dimer interface [polypeptide binding]; other site
438753010403	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753010404	putative CheW interface [polypeptide binding]; other site
438753010405	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
438753010406	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
438753010407	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
438753010408	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
438753010409	Walker A/P-loop; other site
438753010410	ATP binding site [chemical binding]; other site
438753010411	Q-loop/lid; other site
438753010412	ABC transporter signature motif; other site
438753010413	Walker B; other site
438753010414	D-loop; other site
438753010415	H-loop/switch region; other site
438753010416	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
438753010417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753010418	S-adenosylmethionine binding site [chemical binding]; other site
438753010419	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
438753010420	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
438753010421	RNA binding surface [nucleotide binding]; other site
438753010422	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753010423	S-adenosylmethionine binding site [chemical binding]; other site
438753010424	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
438753010425	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
438753010426	TPP-binding site; other site
438753010427	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
438753010428	PYR/PP interface [polypeptide binding]; other site
438753010429	dimer interface [polypeptide binding]; other site
438753010430	TPP binding site [chemical binding]; other site
438753010431	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
438753010432	Rhamnan synthesis protein F; Region: RgpF; pfam05045
438753010433	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
438753010434	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
438753010435	Probable Catalytic site; other site
438753010436	metal-binding site
438753010437	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
438753010438	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
438753010439	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
438753010440	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
438753010441	motif 1; other site
438753010442	dimer interface [polypeptide binding]; other site
438753010443	active site
438753010444	motif 2; other site
438753010445	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
438753010446	active site
438753010447	motif 3; other site
438753010448	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
438753010449	ATP phosphoribosyltransferase; Region: HisG; cl15266
438753010450	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
438753010451	aminopeptidase N; Provisional; Region: pepN; PRK14015
438753010452	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
438753010453	active site
438753010454	Zn binding site [ion binding]; other site
438753010455	LysR family transcriptional regulator; Provisional; Region: PRK14997
438753010456	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753010457	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
438753010458	putative effector binding pocket; other site
438753010459	dimerization interface [polypeptide binding]; other site
438753010460	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753010461	PAS fold; Region: PAS_3; pfam08447
438753010462	putative active site [active]
438753010463	heme pocket [chemical binding]; other site
438753010464	PAS fold; Region: PAS_7; pfam12860
438753010465	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753010466	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753010467	dimer interface [polypeptide binding]; other site
438753010468	phosphorylation site [posttranslational modification]
438753010469	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753010470	ATP binding site [chemical binding]; other site
438753010471	Mg2+ binding site [ion binding]; other site
438753010472	G-X-G motif; other site
438753010473	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
438753010474	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
438753010475	ATP binding site [chemical binding]; other site
438753010476	Mg++ binding site [ion binding]; other site
438753010477	motif III; other site
438753010478	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
438753010479	nucleotide binding region [chemical binding]; other site
438753010480	ATP-binding site [chemical binding]; other site
438753010481	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
438753010482	RNA binding site [nucleotide binding]; other site
438753010483	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
438753010484	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
438753010485	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753010486	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753010487	metal binding site [ion binding]; metal-binding site
438753010488	active site
438753010489	I-site; other site
438753010490	excinuclease ABC subunit B; Provisional; Region: PRK05298
438753010491	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
438753010492	ATP binding site [chemical binding]; other site
438753010493	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
438753010494	nucleotide binding region [chemical binding]; other site
438753010495	ATP-binding site [chemical binding]; other site
438753010496	Ultra-violet resistance protein B; Region: UvrB; pfam12344
438753010497	Ectoine synthase; Region: Ectoine_synth; cl17598
438753010498	Protein of unknown function, DUF486; Region: DUF486; cl01236
438753010499	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
438753010500	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
438753010501	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
438753010502	N-terminal domain interface [polypeptide binding]; other site
438753010503	dimer interface [polypeptide binding]; other site
438753010504	substrate binding pocket (H-site) [chemical binding]; other site
438753010505	aspartate aminotransferase; Provisional; Region: PRK05764
438753010506	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753010507	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753010508	homodimer interface [polypeptide binding]; other site
438753010509	catalytic residue [active]
438753010510	Protein of unknown function (DUF992); Region: DUF992; pfam06186
438753010511	Protein of unknown function (DUF992); Region: DUF992; pfam06186
438753010512	Protein of unknown function (DUF992); Region: DUF992; pfam06186
438753010513	TMAO/DMSO reductase; Reviewed; Region: PRK05363
438753010514	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
438753010515	Moco binding site; other site
438753010516	metal coordination site [ion binding]; other site
438753010517	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
438753010518	B1 nucleotide binding pocket [chemical binding]; other site
438753010519	B2 nucleotide binding pocket [chemical binding]; other site
438753010520	CAS motifs; other site
438753010521	active site
438753010522	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
438753010523	putative glutathione S-transferase; Provisional; Region: PRK10357
438753010524	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
438753010525	putative C-terminal domain interface [polypeptide binding]; other site
438753010526	putative GSH binding site (G-site) [chemical binding]; other site
438753010527	putative dimer interface [polypeptide binding]; other site
438753010528	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
438753010529	N-terminal domain interface [polypeptide binding]; other site
438753010530	dimer interface [polypeptide binding]; other site
438753010531	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
438753010532	putative aminotransferase; Validated; Region: PRK07480
438753010533	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
438753010534	inhibitor-cofactor binding pocket; inhibition site
438753010535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753010536	catalytic residue [active]
438753010537	Domain of unknown function (DUF329); Region: DUF329; cl01144
438753010538	Maf-like protein; Region: Maf; pfam02545
438753010539	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
438753010540	active site
438753010541	dimer interface [polypeptide binding]; other site
438753010542	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
438753010543	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
438753010544	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
438753010545	Low molecular weight phosphatase family; Region: LMWPc; cl00105
438753010546	active site
438753010547	hypothetical protein; Provisional; Region: PRK02853
438753010548	histidinol dehydrogenase; Region: hisD; TIGR00069
438753010549	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
438753010550	NAD binding site [chemical binding]; other site
438753010551	dimerization interface [polypeptide binding]; other site
438753010552	product binding site; other site
438753010553	substrate binding site [chemical binding]; other site
438753010554	zinc binding site [ion binding]; other site
438753010555	catalytic residues [active]
438753010556	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
438753010557	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
438753010558	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
438753010559	hinge; other site
438753010560	active site
438753010561	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
438753010562	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753010563	putative active site [active]
438753010564	heme pocket [chemical binding]; other site
438753010565	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753010566	putative active site [active]
438753010567	heme pocket [chemical binding]; other site
438753010568	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753010569	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753010570	dimer interface [polypeptide binding]; other site
438753010571	putative CheW interface [polypeptide binding]; other site
438753010572	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753010573	dimerization interface [polypeptide binding]; other site
438753010574	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753010575	dimer interface [polypeptide binding]; other site
438753010576	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753010577	putative CheW interface [polypeptide binding]; other site
438753010578	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
438753010579	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
438753010580	active site
438753010581	dimer interface [polypeptide binding]; other site
438753010582	non-prolyl cis peptide bond; other site
438753010583	insertion regions; other site
438753010584	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
438753010585	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
438753010586	active site
438753010587	non-prolyl cis peptide bond; other site
438753010588	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
438753010589	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
438753010590	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753010591	substrate binding pocket [chemical binding]; other site
438753010592	membrane-bound complex binding site; other site
438753010593	hinge residues; other site
438753010594	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753010595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753010596	dimer interface [polypeptide binding]; other site
438753010597	conserved gate region; other site
438753010598	putative PBP binding loops; other site
438753010599	ABC-ATPase subunit interface; other site
438753010600	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
438753010601	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753010602	Walker A/P-loop; other site
438753010603	ATP binding site [chemical binding]; other site
438753010604	Q-loop/lid; other site
438753010605	ABC transporter signature motif; other site
438753010606	Walker B; other site
438753010607	D-loop; other site
438753010608	H-loop/switch region; other site
438753010609	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
438753010610	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753010611	substrate binding pocket [chemical binding]; other site
438753010612	membrane-bound complex binding site; other site
438753010613	hinge residues; other site
438753010614	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753010615	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753010616	dimer interface [polypeptide binding]; other site
438753010617	conserved gate region; other site
438753010618	putative PBP binding loops; other site
438753010619	ABC-ATPase subunit interface; other site
438753010620	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
438753010621	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
438753010622	active site
438753010623	Cytochrome c; Region: Cytochrom_C; pfam00034
438753010624	bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113
438753010625	Moco binding site; other site
438753010626	metal coordination site [ion binding]; other site
438753010627	dimerization interface [polypeptide binding]; other site
438753010628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
438753010629	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753010630	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753010631	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753010632	ABC-ATPase subunit interface; other site
438753010633	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
438753010634	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
438753010635	membrane-bound complex binding site; other site
438753010636	hinge residues; other site
438753010637	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
438753010638	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
438753010639	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
438753010640	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
438753010641	active site
438753010642	non-prolyl cis peptide bond; other site
438753010643	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753010644	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753010645	Walker A/P-loop; other site
438753010646	ATP binding site [chemical binding]; other site
438753010647	Q-loop/lid; other site
438753010648	ABC transporter signature motif; other site
438753010649	Walker B; other site
438753010650	D-loop; other site
438753010651	H-loop/switch region; other site
438753010652	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
438753010653	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
438753010654	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
438753010655	active site
438753010656	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
438753010657	dimer interface [polypeptide binding]; other site
438753010658	FMN binding site [chemical binding]; other site
438753010659	NADPH bind site [chemical binding]; other site
438753010660	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
438753010661	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753010662	membrane-bound complex binding site; other site
438753010663	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
438753010664	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
438753010665	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
438753010666	Predicted transcriptional regulator [Transcription]; Region: COG1959
438753010667	Transcriptional regulator; Region: Rrf2; pfam02082
438753010668	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
438753010669	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
438753010670	active site
438753010671	non-prolyl cis peptide bond; other site
438753010672	hypothetical protein; Provisional; Region: PRK01254
438753010673	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
438753010674	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
438753010675	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
438753010676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753010677	S-adenosylmethionine binding site [chemical binding]; other site
438753010678	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
438753010679	MarR family; Region: MarR; pfam01047
438753010680	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
438753010681	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
438753010682	acyl-activating enzyme (AAE) consensus motif; other site
438753010683	AMP binding site [chemical binding]; other site
438753010684	active site
438753010685	CoA binding site [chemical binding]; other site
438753010686	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
438753010687	homotrimer interaction site [polypeptide binding]; other site
438753010688	putative active site [active]
438753010689	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
438753010690	active site
438753010691	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
438753010692	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
438753010693	active site
438753010694	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
438753010695	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
438753010696	substrate binding site [chemical binding]; other site
438753010697	oxyanion hole (OAH) forming residues; other site
438753010698	trimer interface [polypeptide binding]; other site
438753010699	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
438753010700	classical (c) SDRs; Region: SDR_c; cd05233
438753010701	NAD(P) binding site [chemical binding]; other site
438753010702	active site
438753010703	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
438753010704	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
438753010705	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
438753010706	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
438753010707	active site
438753010708	FMN binding site [chemical binding]; other site
438753010709	substrate binding site [chemical binding]; other site
438753010710	homotetramer interface [polypeptide binding]; other site
438753010711	catalytic residue [active]
438753010712	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753010713	Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359
438753010714	putative ligand binding site [chemical binding]; other site
438753010715	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753010716	TM-ABC transporter signature motif; other site
438753010717	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753010718	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753010719	TM-ABC transporter signature motif; other site
438753010720	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753010721	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753010722	Walker A/P-loop; other site
438753010723	ATP binding site [chemical binding]; other site
438753010724	Q-loop/lid; other site
438753010725	ABC transporter signature motif; other site
438753010726	Walker B; other site
438753010727	D-loop; other site
438753010728	H-loop/switch region; other site
438753010729	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753010730	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753010731	Walker A/P-loop; other site
438753010732	ATP binding site [chemical binding]; other site
438753010733	Q-loop/lid; other site
438753010734	ABC transporter signature motif; other site
438753010735	Walker B; other site
438753010736	D-loop; other site
438753010737	H-loop/switch region; other site
438753010738	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
438753010739	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753010740	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
438753010741	dimer interface [polypeptide binding]; other site
438753010742	putative metal binding site [ion binding]; other site
438753010743	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
438753010744	Transcriptional regulator [Transcription]; Region: IclR; COG1414
438753010745	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753010746	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
438753010747	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
438753010748	putative ligand binding site [chemical binding]; other site
438753010749	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
438753010750	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
438753010751	Walker A/P-loop; other site
438753010752	ATP binding site [chemical binding]; other site
438753010753	Q-loop/lid; other site
438753010754	ABC transporter signature motif; other site
438753010755	Walker B; other site
438753010756	D-loop; other site
438753010757	H-loop/switch region; other site
438753010758	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
438753010759	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4603
438753010760	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
438753010761	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753010762	TM-ABC transporter signature motif; other site
438753010763	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
438753010764	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753010765	TM-ABC transporter signature motif; other site
438753010766	Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663
438753010767	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753010768	Amidase; Region: Amidase; cl11426
438753010769	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
438753010770	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753010771	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
438753010772	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
438753010773	putative active site [active]
438753010774	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
438753010775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753010776	Walker A/P-loop; other site
438753010777	ATP binding site [chemical binding]; other site
438753010778	Q-loop/lid; other site
438753010779	ABC transporter signature motif; other site
438753010780	Walker B; other site
438753010781	D-loop; other site
438753010782	H-loop/switch region; other site
438753010783	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
438753010784	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
438753010785	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753010786	Walker A/P-loop; other site
438753010787	ATP binding site [chemical binding]; other site
438753010788	Q-loop/lid; other site
438753010789	ABC transporter signature motif; other site
438753010790	Walker B; other site
438753010791	D-loop; other site
438753010792	H-loop/switch region; other site
438753010793	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
438753010794	Domain of unknown function (DUF4135); Region: DUF4135; pfam13575
438753010795	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
438753010796	active site
438753010797	zinc binding site [ion binding]; other site
438753010798	Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family [General function prediction only]; Region: COG4015
438753010799	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753010800	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
438753010801	putative ligand binding site [chemical binding]; other site
438753010802	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753010803	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
438753010804	NAD(P) binding site [chemical binding]; other site
438753010805	active site
438753010806	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
438753010807	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
438753010808	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
438753010809	PAS fold; Region: PAS; pfam00989
438753010810	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
438753010811	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753010812	Walker A motif; other site
438753010813	ATP binding site [chemical binding]; other site
438753010814	Walker B motif; other site
438753010815	arginine finger; other site
438753010816	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
438753010817	hypothetical protein; Provisional; Region: PRK09936
438753010818	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
438753010819	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
438753010820	active site
438753010821	homodimer interface [polypeptide binding]; other site
438753010822	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
438753010823	active site
438753010824	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
438753010825	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
438753010826	Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182
438753010827	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
438753010828	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
438753010829	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753010830	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
438753010831	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753010832	benzoate transport; Region: 2A0115; TIGR00895
438753010833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753010834	putative substrate translocation pore; other site
438753010835	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
438753010836	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753010837	active site
438753010838	GAF domain; Region: GAF; pfam01590
438753010839	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
438753010840	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753010841	metal binding site [ion binding]; metal-binding site
438753010842	active site
438753010843	I-site; other site
438753010844	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753010845	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
438753010846	catalytic triad [active]
438753010847	putative active site [active]
438753010848	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
438753010849	Autotransporter beta-domain; Region: Autotransporter; pfam03797
438753010850	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
438753010851	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753010852	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753010853	binding surface
438753010854	TPR motif; other site
438753010855	TPR repeat; Region: TPR_11; pfam13414
438753010856	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
438753010857	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753010858	binding surface
438753010859	TPR motif; other site
438753010860	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
438753010861	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
438753010862	Autotransporter beta-domain; Region: Autotransporter; pfam03797
438753010863	Autotransporter beta-domain; Region: Autotransporter; smart00869
438753010864	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
438753010865	DNA-binding site [nucleotide binding]; DNA binding site
438753010866	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
438753010867	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
438753010868	Walker A/P-loop; other site
438753010869	ATP binding site [chemical binding]; other site
438753010870	Q-loop/lid; other site
438753010871	ABC transporter signature motif; other site
438753010872	Walker B; other site
438753010873	D-loop; other site
438753010874	H-loop/switch region; other site
438753010875	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753010876	RNA polymerase sigma factor; Reviewed; Region: PRK12527
438753010877	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
438753010878	DNA binding residues [nucleotide binding]
438753010879	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
438753010880	FecR protein; Region: FecR; pfam04773
438753010881	ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049
438753010882	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
438753010883	N-terminal plug; other site
438753010884	ligand-binding site [chemical binding]; other site
438753010885	Protein of unknown function (DUF418); Region: DUF418; cl12135
438753010886	Protein of unknown function (DUF418); Region: DUF418; cl12135
438753010887	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
438753010888	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753010889	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
438753010890	hypothetical protein; Provisional; Region: PRK05968
438753010891	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
438753010892	homodimer interface [polypeptide binding]; other site
438753010893	substrate-cofactor binding pocket; other site
438753010894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753010895	catalytic residue [active]
438753010896	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
438753010897	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
438753010898	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
438753010899	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
438753010900	Condensation domain; Region: Condensation; pfam00668
438753010901	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
438753010902	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
438753010903	acyl-activating enzyme (AAE) consensus motif; other site
438753010904	AMP binding site [chemical binding]; other site
438753010905	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
438753010906	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
438753010907	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
438753010908	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
438753010909	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
438753010910	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
438753010911	siderophore binding site; other site
438753010912	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
438753010913	FecCD transport family; Region: FecCD; pfam01032
438753010914	ABC-ATPase subunit  interface; other site
438753010915	dimer interface [polypeptide binding]; other site
438753010916	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
438753010917	ABC-ATPase subunit  interface; other site
438753010918	dimer interface [polypeptide binding]; other site
438753010919	putative PBP binding regions; other site
438753010920	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
438753010921	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
438753010922	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
438753010923	Integrase core domain; Region: rve; pfam00665
438753010924	DDE superfamily endonuclease; Region: DDE_3; pfam13358
438753010925	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
438753010926	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
438753010927	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
438753010928	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
438753010929	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753010930	sequence-specific DNA binding site [nucleotide binding]; other site
438753010931	salt bridge; other site
438753010932	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
438753010933	DNA methylase; Region: N6_N4_Mtase; cl17433
438753010934	DNA methylase; Region: N6_N4_Mtase; cl17433
438753010935	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
438753010936	AAA domain; Region: AAA_23; pfam13476
438753010937	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753010938	Walker A/P-loop; other site
438753010939	ATP binding site [chemical binding]; other site
438753010940	HTH-like domain; Region: HTH_21; pfam13276
438753010941	Integrase core domain; Region: rve; pfam00665
438753010942	Integrase core domain; Region: rve_3; pfam13683
438753010943	Transposase; Region: HTH_Tnp_1; pfam01527
438753010944	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
438753010945	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
438753010946	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
438753010947	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753010948	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753010949	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
438753010950	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
438753010951	putative C-terminal domain interface [polypeptide binding]; other site
438753010952	putative GSH binding site (G-site) [chemical binding]; other site
438753010953	putative dimer interface [polypeptide binding]; other site
438753010954	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
438753010955	putative N-terminal domain interface [polypeptide binding]; other site
438753010956	putative dimer interface [polypeptide binding]; other site
438753010957	putative substrate binding pocket (H-site) [chemical binding]; other site
438753010958	choline dehydrogenase; Validated; Region: PRK02106
438753010959	lycopene cyclase; Region: lycopene_cycl; TIGR01789
438753010960	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
438753010961	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
438753010962	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753010963	dimer interface [polypeptide binding]; other site
438753010964	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753010965	putative CheW interface [polypeptide binding]; other site
438753010966	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
438753010967	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
438753010968	catalytic Zn binding site [ion binding]; other site
438753010969	NAD(P) binding site [chemical binding]; other site
438753010970	structural Zn binding site [ion binding]; other site
438753010971	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753010972	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753010973	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
438753010974	putative effector binding pocket; other site
438753010975	putative dimerization interface [polypeptide binding]; other site
438753010976	Uncharacterized conserved protein [Function unknown]; Region: COG4925
438753010977	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
438753010978	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753010979	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
438753010980	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753010981	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753010982	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753010983	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
438753010984	catalytic loop [active]
438753010985	iron binding site [ion binding]; other site
438753010986	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
438753010987	Cytochrome c; Region: Cytochrom_C; cl11414
438753010988	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753010989	putative substrate translocation pore; other site
438753010990	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753010991	galactarate dehydratase; Region: galactar-dH20; TIGR03248
438753010992	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
438753010993	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
438753010994	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
438753010995	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
438753010996	putative NAD(P) binding site [chemical binding]; other site
438753010997	catalytic Zn binding site [ion binding]; other site
438753010998	structural Zn binding site [ion binding]; other site
438753010999	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753011000	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753011001	substrate binding pocket [chemical binding]; other site
438753011002	membrane-bound complex binding site; other site
438753011003	hinge residues; other site
438753011004	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753011005	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753011006	Walker A/P-loop; other site
438753011007	ATP binding site [chemical binding]; other site
438753011008	Q-loop/lid; other site
438753011009	ABC transporter signature motif; other site
438753011010	Walker B; other site
438753011011	D-loop; other site
438753011012	H-loop/switch region; other site
438753011013	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753011014	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753011015	dimer interface [polypeptide binding]; other site
438753011016	conserved gate region; other site
438753011017	putative PBP binding loops; other site
438753011018	ABC-ATPase subunit interface; other site
438753011019	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753011020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753011021	dimer interface [polypeptide binding]; other site
438753011022	conserved gate region; other site
438753011023	putative PBP binding loops; other site
438753011024	ABC-ATPase subunit interface; other site
438753011025	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
438753011026	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
438753011027	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753011028	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753011029	DNA-binding site [nucleotide binding]; DNA binding site
438753011030	FCD domain; Region: FCD; pfam07729
438753011031	multidrug efflux protein; Reviewed; Region: PRK09579
438753011032	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
438753011033	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753011034	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753011035	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
438753011036	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753011037	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753011038	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
438753011039	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
438753011040	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
438753011041	dimer interface [polypeptide binding]; other site
438753011042	active site
438753011043	heme binding site [chemical binding]; other site
438753011044	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
438753011045	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
438753011046	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753011047	dimer interface [polypeptide binding]; other site
438753011048	phosphorylation site [posttranslational modification]
438753011049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753011050	ATP binding site [chemical binding]; other site
438753011051	Mg2+ binding site [ion binding]; other site
438753011052	G-X-G motif; other site
438753011053	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
438753011054	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753011055	active site
438753011056	phosphorylation site [posttranslational modification]
438753011057	intermolecular recognition site; other site
438753011058	dimerization interface [polypeptide binding]; other site
438753011059	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
438753011060	DNA binding residues [nucleotide binding]
438753011061	dimerization interface [polypeptide binding]; other site
438753011062	Domain of unknown function (DUF336); Region: DUF336; pfam03928
438753011063	manganese transport protein MntH; Reviewed; Region: PRK00701
438753011064	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
438753011065	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753011066	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753011067	DNA-binding site [nucleotide binding]; DNA binding site
438753011068	FCD domain; Region: FCD; pfam07729
438753011069	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
438753011070	heme-binding site [chemical binding]; other site
438753011071	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
438753011072	malonyl-CoA synthase; Validated; Region: PRK07514
438753011073	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
438753011074	acyl-activating enzyme (AAE) consensus motif; other site
438753011075	active site
438753011076	AMP binding site [chemical binding]; other site
438753011077	CoA binding site [chemical binding]; other site
438753011078	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
438753011079	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
438753011080	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
438753011081	DctM-like transporters; Region: DctM; pfam06808
438753011082	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
438753011083	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
438753011084	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
438753011085	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
438753011086	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
438753011087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
438753011088	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
438753011089	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
438753011090	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
438753011091	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
438753011092	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
438753011093	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
438753011094	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
438753011095	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
438753011096	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753011097	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753011098	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
438753011099	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
438753011100	ATP binding site [chemical binding]; other site
438753011101	putative Mg++ binding site [ion binding]; other site
438753011102	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
438753011103	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
438753011104	SEC-C motif; Region: SEC-C; pfam02810
438753011105	Uncharacterized conserved protein [Function unknown]; Region: COG1479
438753011106	Protein of unknown function DUF262; Region: DUF262; pfam03235
438753011107	Uncharacterized conserved protein [Function unknown]; Region: COG3472
438753011108	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753011109	H-loop/switch region; other site
438753011110	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753011111	H-loop/switch region; other site
438753011112	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
438753011113	Amidase; Region: Amidase; cl11426
438753011114	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
438753011115	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753011116	Walker A/P-loop; other site
438753011117	ATP binding site [chemical binding]; other site
438753011118	Q-loop/lid; other site
438753011119	ABC transporter signature motif; other site
438753011120	Walker B; other site
438753011121	D-loop; other site
438753011122	H-loop/switch region; other site
438753011123	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
438753011124	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
438753011125	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
438753011126	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
438753011127	YGGT family; Region: YGGT; pfam02325
438753011128	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
438753011129	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
438753011130	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
438753011131	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
438753011132	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753011133	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
438753011134	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
438753011135	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753011136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753011137	S-adenosylmethionine binding site [chemical binding]; other site
438753011138	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
438753011139	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
438753011140	Probable Catalytic site; other site
438753011141	metal-binding site
438753011142	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
438753011143	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
438753011144	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
438753011145	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
438753011146	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753011147	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
438753011148	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
438753011149	Walker A/P-loop; other site
438753011150	ATP binding site [chemical binding]; other site
438753011151	Q-loop/lid; other site
438753011152	ABC transporter signature motif; other site
438753011153	Walker B; other site
438753011154	D-loop; other site
438753011155	H-loop/switch region; other site
438753011156	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
438753011157	MarR family; Region: MarR_2; pfam12802
438753011158	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753011159	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
438753011160	putative ADP-binding pocket [chemical binding]; other site
438753011161	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
438753011162	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
438753011163	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
438753011164	Cupin domain; Region: Cupin_2; pfam07883
438753011165	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
438753011166	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
438753011167	NADP binding site [chemical binding]; other site
438753011168	homodimer interface [polypeptide binding]; other site
438753011169	active site
438753011170	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
438753011171	DctM-like transporters; Region: DctM; pfam06808
438753011172	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
438753011173	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
438753011174	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
438753011175	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
438753011176	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753011177	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753011178	DNA-binding site [nucleotide binding]; DNA binding site
438753011179	FCD domain; Region: FCD; pfam07729
438753011180	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
438753011181	galactarate dehydratase; Region: galactar-dH20; TIGR03248
438753011182	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
438753011183	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753011184	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753011185	DNA-binding site [nucleotide binding]; DNA binding site
438753011186	FCD domain; Region: FCD; pfam07729
438753011187	glucuronate isomerase; Reviewed; Region: PRK02925
438753011188	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
438753011189	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
438753011190	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
438753011191	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
438753011192	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753011193	Walker A/P-loop; other site
438753011194	ATP binding site [chemical binding]; other site
438753011195	Q-loop/lid; other site
438753011196	ABC transporter signature motif; other site
438753011197	Walker B; other site
438753011198	D-loop; other site
438753011199	H-loop/switch region; other site
438753011200	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
438753011201	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
438753011202	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
438753011203	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
438753011204	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
438753011205	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
438753011206	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
438753011207	classical (c) SDRs; Region: SDR_c; cd05233
438753011208	NAD(P) binding site [chemical binding]; other site
438753011209	active site
438753011210	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753011211	dimer interface [polypeptide binding]; other site
438753011212	putative CheW interface [polypeptide binding]; other site
438753011213	PilZ domain; Region: PilZ; pfam07238
438753011214	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
438753011215	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
438753011216	hypothetical protein; Provisional; Region: PRK09262
438753011217	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
438753011218	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
438753011219	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
438753011220	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
438753011221	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
438753011222	active site
438753011223	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
438753011224	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753011225	active site
438753011226	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
438753011227	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
438753011228	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753011229	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753011230	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
438753011231	putative dimerization interface [polypeptide binding]; other site
438753011232	PBP superfamily domain; Region: PBP_like_2; cl17296
438753011233	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
438753011234	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
438753011235	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
438753011236	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
438753011237	putative ligand binding site [chemical binding]; other site
438753011238	NAD binding site [chemical binding]; other site
438753011239	dimerization interface [polypeptide binding]; other site
438753011240	catalytic site [active]
438753011241	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
438753011242	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
438753011243	Domain of unknown function DUF59; Region: DUF59; pfam01883
438753011244	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
438753011245	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
438753011246	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
438753011247	putative uracil binding site [chemical binding]; other site
438753011248	putative active site [active]
438753011249	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
438753011250	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
438753011251	putative C-terminal domain interface [polypeptide binding]; other site
438753011252	putative GSH binding site (G-site) [chemical binding]; other site
438753011253	putative dimer interface [polypeptide binding]; other site
438753011254	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
438753011255	putative N-terminal domain interface [polypeptide binding]; other site
438753011256	putative dimer interface [polypeptide binding]; other site
438753011257	putative substrate binding pocket (H-site) [chemical binding]; other site
438753011258	acyl-CoA synthetase; Validated; Region: PRK05850
438753011259	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
438753011260	acyl-activating enzyme (AAE) consensus motif; other site
438753011261	active site
438753011262	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
438753011263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753011264	putative transporter; Provisional; Region: PRK10504
438753011265	putative substrate translocation pore; other site
438753011266	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753011267	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
438753011268	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753011269	S-adenosylmethionine binding site [chemical binding]; other site
438753011270	exopolyphosphatase; Region: exo_poly_only; TIGR03706
438753011271	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
438753011272	putative translaldolase; Provisional; Region: PRK12376
438753011273	catalytic residue [active]
438753011274	hypothetical protein; Provisional; Region: PRK06034
438753011275	Chorismate mutase type II; Region: CM_2; smart00830
438753011276	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
438753011277	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
438753011278	active site
438753011279	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
438753011280	flagellin; Reviewed; Region: PRK12687
438753011281	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
438753011282	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753011283	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753011284	metal binding site [ion binding]; metal-binding site
438753011285	active site
438753011286	I-site; other site
438753011287	MoxR-like ATPases [General function prediction only]; Region: COG0714
438753011288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753011289	Walker A motif; other site
438753011290	ATP binding site [chemical binding]; other site
438753011291	arginine finger; other site
438753011292	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
438753011293	Protein of unknown function DUF58; Region: DUF58; pfam01882
438753011294	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
438753011295	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
438753011296	metal ion-dependent adhesion site (MIDAS); other site
438753011297	von Willebrand factor type A domain; Region: VWA_2; pfam13519
438753011298	metal ion-dependent adhesion site (MIDAS); other site
438753011299	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753011300	Tetratricopeptide repeat; Region: TPR_16; pfam13432
438753011301	TPR motif; other site
438753011302	binding surface
438753011303	Oxygen tolerance; Region: BatD; pfam13584
438753011304	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
438753011305	nudix motif; other site
438753011306	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
438753011307	serine O-acetyltransferase; Region: cysE; TIGR01172
438753011308	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
438753011309	trimer interface [polypeptide binding]; other site
438753011310	active site
438753011311	substrate binding site [chemical binding]; other site
438753011312	CoA binding site [chemical binding]; other site
438753011313	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
438753011314	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
438753011315	active site
438753011316	catalytic residues [active]
438753011317	metal binding site [ion binding]; metal-binding site
438753011318	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
438753011319	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
438753011320	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753011321	DNA-binding site [nucleotide binding]; DNA binding site
438753011322	UTRA domain; Region: UTRA; pfam07702
438753011323	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
438753011324	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
438753011325	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
438753011326	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
438753011327	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
438753011328	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753011329	Coenzyme A binding pocket [chemical binding]; other site
438753011330	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
438753011331	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753011332	Walker A/P-loop; other site
438753011333	ATP binding site [chemical binding]; other site
438753011334	Q-loop/lid; other site
438753011335	ABC transporter signature motif; other site
438753011336	Walker B; other site
438753011337	D-loop; other site
438753011338	H-loop/switch region; other site
438753011339	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753011340	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753011341	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
438753011342	Walker A/P-loop; other site
438753011343	ATP binding site [chemical binding]; other site
438753011344	Q-loop/lid; other site
438753011345	ABC transporter signature motif; other site
438753011346	Walker B; other site
438753011347	D-loop; other site
438753011348	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
438753011349	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753011350	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753011351	active site
438753011352	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
438753011353	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
438753011354	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
438753011355	active site residue [active]
438753011356	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
438753011357	active site residue [active]
438753011358	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
438753011359	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
438753011360	iron-sulfur cluster [ion binding]; other site
438753011361	[2Fe-2S] cluster binding site [ion binding]; other site
438753011362	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
438753011363	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753011364	Walker A motif; other site
438753011365	ATP binding site [chemical binding]; other site
438753011366	Walker B motif; other site
438753011367	arginine finger; other site
438753011368	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
438753011369	NifU-like domain; Region: NifU; cl00484
438753011370	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
438753011371	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
438753011372	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
438753011373	catalytic residue [active]
438753011374	NifT/FixU protein; Region: NifT; pfam06988
438753011375	SIR2-like domain; Region: SIR2_2; pfam13289
438753011376	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
438753011377	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753011378	FeS/SAM binding site; other site
438753011379	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
438753011380	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
438753011381	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
438753011382	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
438753011383	NifZ domain; Region: NifZ; pfam04319
438753011384	NifZ domain; Region: NifZ; pfam04319
438753011385	Protein of unknown function (DUF3024); Region: DUF3024; pfam11225
438753011386	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
438753011387	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
438753011388	inhibitor-cofactor binding pocket; inhibition site
438753011389	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753011390	catalytic residue [active]
438753011391	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
438753011392	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753011393	catalytic loop [active]
438753011394	iron binding site [ion binding]; other site
438753011395	FAD binding domain; Region: FAD_binding_1; pfam00667
438753011396	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
438753011397	FAD binding pocket [chemical binding]; other site
438753011398	conserved FAD binding motif [chemical binding]; other site
438753011399	phosphate binding motif [ion binding]; other site
438753011400	beta-alpha-beta structure motif; other site
438753011401	NAD binding pocket [chemical binding]; other site
438753011402	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
438753011403	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
438753011404	C-terminal domain interface [polypeptide binding]; other site
438753011405	GSH binding site (G-site) [chemical binding]; other site
438753011406	dimer interface [polypeptide binding]; other site
438753011407	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
438753011408	dimer interface [polypeptide binding]; other site
438753011409	substrate binding pocket (H-site) [chemical binding]; other site
438753011410	N-terminal domain interface [polypeptide binding]; other site
438753011411	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
438753011412	iron-sulfur cluster [ion binding]; other site
438753011413	[2Fe-2S] cluster binding site [ion binding]; other site
438753011414	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
438753011415	apolar tunnel; other site
438753011416	heme binding site [chemical binding]; other site
438753011417	dimerization interface [polypeptide binding]; other site
438753011418	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
438753011419	Domain of unknown function DUF59; Region: DUF59; cl00941
438753011420	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
438753011421	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
438753011422	putative GSH binding site [chemical binding]; other site
438753011423	catalytic residues [active]
438753011424	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
438753011425	active site residue [active]
438753011426	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
438753011427	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
438753011428	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
438753011429	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
438753011430	NADPH bind site [chemical binding]; other site
438753011431	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
438753011432	putative FMN binding site [chemical binding]; other site
438753011433	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
438753011434	ArsC family; Region: ArsC; pfam03960
438753011435	putative catalytic residues [active]
438753011436	Response regulator receiver domain; Region: Response_reg; pfam00072
438753011437	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753011438	active site
438753011439	phosphorylation site [posttranslational modification]
438753011440	intermolecular recognition site; other site
438753011441	dimerization interface [polypeptide binding]; other site
438753011442	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
438753011443	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
438753011444	Nucleotide-binding sites [chemical binding]; other site
438753011445	Walker A motif; other site
438753011446	Switch I region of nucleotide binding site; other site
438753011447	Fe4S4 binding sites [ion binding]; other site
438753011448	Switch II region of nucleotide binding site; other site
438753011449	NifQ; Region: NifQ; pfam04891
438753011450	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
438753011451	metal binding site 2 [ion binding]; metal-binding site
438753011452	putative DNA binding helix; other site
438753011453	metal binding site 1 [ion binding]; metal-binding site
438753011454	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810
438753011455	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
438753011456	Ligand binding site [chemical binding]; other site
438753011457	Electron transfer flavoprotein domain; Region: ETF; pfam01012
438753011458	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
438753011459	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
438753011460	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
438753011461	oxidoreductase; Provisional; Region: PRK10015
438753011462	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
438753011463	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
438753011464	Rop-like; Region: Rop-like; pfam05082
438753011465	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
438753011466	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
438753011467	putative dimer interface [polypeptide binding]; other site
438753011468	[2Fe-2S] cluster binding site [ion binding]; other site
438753011469	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
438753011470	putative dimer interface [polypeptide binding]; other site
438753011471	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
438753011472	SLBB domain; Region: SLBB; pfam10531
438753011473	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
438753011474	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
438753011475	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
438753011476	catalytic loop [active]
438753011477	iron binding site [ion binding]; other site
438753011478	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
438753011479	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
438753011480	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
438753011481	[4Fe-4S] binding site [ion binding]; other site
438753011482	molybdopterin cofactor binding site; other site
438753011483	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
438753011484	molybdopterin cofactor binding site; other site
438753011485	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
438753011486	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
438753011487	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
438753011488	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
438753011489	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
438753011490	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
438753011491	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
438753011492	serine acetyltransferase; Provisional; Region: cysE; PRK11132
438753011493	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
438753011494	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
438753011495	trimer interface [polypeptide binding]; other site
438753011496	active site
438753011497	substrate binding site [chemical binding]; other site
438753011498	CoA binding site [chemical binding]; other site
438753011499	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
438753011500	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
438753011501	nucleophilic elbow; other site
438753011502	catalytic triad; other site
438753011503	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
438753011504	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
438753011505	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
438753011506	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
438753011507	putative ligand binding site [chemical binding]; other site
438753011508	NAD binding site [chemical binding]; other site
438753011509	dimerization interface [polypeptide binding]; other site
438753011510	catalytic site [active]
438753011511	TPR repeat; Region: TPR_11; pfam13414
438753011512	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753011513	TPR motif; other site
438753011514	binding surface
438753011515	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
438753011516	TPR repeat; Region: TPR_11; pfam13414
438753011517	binding surface
438753011518	TPR motif; other site
438753011519	TPR repeat; Region: TPR_11; pfam13414
438753011520	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
438753011521	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
438753011522	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753011523	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
438753011524	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
438753011525	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
438753011526	inhibitor-cofactor binding pocket; inhibition site
438753011527	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753011528	catalytic residue [active]
438753011529	Cephalosporin hydroxylase; Region: CmcI; pfam04989
438753011530	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
438753011531	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
438753011532	WbqC-like protein family; Region: WbqC; pfam08889
438753011533	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
438753011534	Methyltransferase domain; Region: Methyltransf_23; pfam13489
438753011535	Methyltransferase domain; Region: Methyltransf_11; pfam08241
438753011536	CoA binding domain; Region: CoA_binding; cl17356
438753011537	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
438753011538	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
438753011539	active site
438753011540	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
438753011541	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
438753011542	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
438753011543	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753011544	S-adenosylmethionine binding site [chemical binding]; other site
438753011545	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
438753011546	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
438753011547	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753011548	NAD(P) binding site [chemical binding]; other site
438753011549	active site
438753011550	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
438753011551	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
438753011552	substrate binding site; other site
438753011553	HAMP domain; Region: HAMP; pfam00672
438753011554	dimerization interface [polypeptide binding]; other site
438753011555	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753011556	dimer interface [polypeptide binding]; other site
438753011557	putative CheW interface [polypeptide binding]; other site
438753011558	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
438753011559	RNA polymerase sigma factor; Provisional; Region: PRK12512
438753011560	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753011561	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
438753011562	DNA binding residues [nucleotide binding]
438753011563	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
438753011564	hypothetical protein; Provisional; Region: PRK05409
438753011565	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
438753011566	glyoxylate carboligase; Provisional; Region: PRK11269
438753011567	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
438753011568	PYR/PP interface [polypeptide binding]; other site
438753011569	dimer interface [polypeptide binding]; other site
438753011570	TPP binding site [chemical binding]; other site
438753011571	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
438753011572	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
438753011573	TPP-binding site [chemical binding]; other site
438753011574	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
438753011575	tartronate semialdehyde reductase; Provisional; Region: PRK15059
438753011576	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
438753011577	pyruvate kinase; Provisional; Region: PRK06247
438753011578	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
438753011579	domain interfaces; other site
438753011580	active site
438753011581	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
438753011582	putative active site [active]
438753011583	putative metal binding residues [ion binding]; other site
438753011584	signature motif; other site
438753011585	putative dimer interface [polypeptide binding]; other site
438753011586	putative phosphate binding site [ion binding]; other site
438753011587	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
438753011588	Fe-S cluster binding site [ion binding]; other site
438753011589	active site
438753011590	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
438753011591	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
438753011592	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
438753011593	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
438753011594	active site
438753011595	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
438753011596	catalytic residues [active]
438753011597	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
438753011598	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
438753011599	cytochrome b; Provisional; Region: CYTB; MTH00156
438753011600	Qi binding site; other site
438753011601	intrachain domain interface; other site
438753011602	interchain domain interface [polypeptide binding]; other site
438753011603	heme bH binding site [chemical binding]; other site
438753011604	heme bL binding site [chemical binding]; other site
438753011605	Qo binding site; other site
438753011606	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
438753011607	interchain domain interface [polypeptide binding]; other site
438753011608	intrachain domain interface; other site
438753011609	Qi binding site; other site
438753011610	Qo binding site; other site
438753011611	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
438753011612	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
438753011613	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
438753011614	[2Fe-2S] cluster binding site [ion binding]; other site
438753011615	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
438753011616	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
438753011617	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
438753011618	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
438753011619	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
438753011620	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
438753011621	active site
438753011622	NTP binding site [chemical binding]; other site
438753011623	metal binding triad [ion binding]; metal-binding site
438753011624	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
438753011625	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
438753011626	putative active site [active]
438753011627	putative CoA binding site [chemical binding]; other site
438753011628	nudix motif; other site
438753011629	metal binding site [ion binding]; metal-binding site
438753011630	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
438753011631	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
438753011632	MoxR-like ATPases [General function prediction only]; Region: COG0714
438753011633	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753011634	Walker A motif; other site
438753011635	ATP binding site [chemical binding]; other site
438753011636	Walker B motif; other site
438753011637	arginine finger; other site
438753011638	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
438753011639	Protein of unknown function DUF58; Region: DUF58; pfam01882
438753011640	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
438753011641	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
438753011642	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
438753011643	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
438753011644	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
438753011645	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
438753011646	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
438753011647	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
438753011648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753011649	dimer interface [polypeptide binding]; other site
438753011650	conserved gate region; other site
438753011651	putative PBP binding loops; other site
438753011652	ABC-ATPase subunit interface; other site
438753011653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753011654	dimer interface [polypeptide binding]; other site
438753011655	conserved gate region; other site
438753011656	putative PBP binding loops; other site
438753011657	ABC-ATPase subunit interface; other site
438753011658	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
438753011659	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
438753011660	Walker A/P-loop; other site
438753011661	ATP binding site [chemical binding]; other site
438753011662	Q-loop/lid; other site
438753011663	ABC transporter signature motif; other site
438753011664	Walker B; other site
438753011665	D-loop; other site
438753011666	H-loop/switch region; other site
438753011667	TOBE domain; Region: TOBE_2; pfam08402
438753011668	Cytochrome P450; Region: p450; pfam00067
438753011669	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
438753011670	Flavodoxin; Region: Flavodoxin_1; pfam00258
438753011671	FAD binding domain; Region: FAD_binding_1; pfam00667
438753011672	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
438753011673	FAD binding pocket [chemical binding]; other site
438753011674	FAD binding motif [chemical binding]; other site
438753011675	catalytic residues [active]
438753011676	NAD binding pocket [chemical binding]; other site
438753011677	phosphate binding motif [ion binding]; other site
438753011678	beta-alpha-beta structure motif; other site
438753011679	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
438753011680	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
438753011681	active site
438753011682	TDP-binding site; other site
438753011683	acceptor substrate-binding pocket; other site
438753011684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753011685	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753011686	putative substrate translocation pore; other site
438753011687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753011688	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753011689	CVNH domain; Region: CVNH; pfam08881
438753011690	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
438753011691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
438753011692	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753011693	sequence-specific DNA binding site [nucleotide binding]; other site
438753011694	salt bridge; other site
438753011695	Cupin domain; Region: Cupin_2; pfam07883
438753011696	classical (c) SDRs; Region: SDR_c; cd05233
438753011697	NAD(P) binding site [chemical binding]; other site
438753011698	active site
438753011699	Porin subfamily; Region: Porin_2; pfam02530
438753011700	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
438753011701	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
438753011702	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
438753011703	Transporter associated domain; Region: CorC_HlyC; smart01091
438753011704	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
438753011705	glutaminase; Provisional; Region: PRK00971
438753011706	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753011707	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753011708	metal binding site [ion binding]; metal-binding site
438753011709	active site
438753011710	I-site; other site
438753011711	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753011712	metal binding site [ion binding]; metal-binding site
438753011713	active site
438753011714	I-site; other site
438753011715	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753011716	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
438753011717	thiamine phosphate binding site [chemical binding]; other site
438753011718	active site
438753011719	pyrophosphate binding site [ion binding]; other site
438753011720	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
438753011721	putative catalytic site [active]
438753011722	putative metal binding site [ion binding]; other site
438753011723	putative phosphate binding site [ion binding]; other site
438753011724	salicylate hydroxylase; Provisional; Region: PRK08163
438753011725	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
438753011726	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
438753011727	2-isopropylmalate synthase; Validated; Region: PRK00915
438753011728	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
438753011729	active site
438753011730	catalytic residues [active]
438753011731	metal binding site [ion binding]; metal-binding site
438753011732	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
438753011733	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
438753011734	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
438753011735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
438753011736	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
438753011737	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
438753011738	FAD binding pocket [chemical binding]; other site
438753011739	FAD binding motif [chemical binding]; other site
438753011740	phosphate binding motif [ion binding]; other site
438753011741	NAD binding pocket [chemical binding]; other site
438753011742	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
438753011743	ThiS interaction site; other site
438753011744	putative active site [active]
438753011745	tetramer interface [polypeptide binding]; other site
438753011746	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
438753011747	thiS-thiF/thiG interaction site; other site
438753011748	hydroxyglutarate oxidase; Provisional; Region: PRK11728
438753011749	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
438753011750	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
438753011751	MarR family; Region: MarR; pfam01047
438753011752	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
438753011753	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
438753011754	putative C-terminal domain interface [polypeptide binding]; other site
438753011755	putative GSH binding site (G-site) [chemical binding]; other site
438753011756	putative dimer interface [polypeptide binding]; other site
438753011757	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
438753011758	dimer interface [polypeptide binding]; other site
438753011759	N-terminal domain interface [polypeptide binding]; other site
438753011760	putative substrate binding pocket (H-site) [chemical binding]; other site
438753011761	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
438753011762	nudix motif; other site
438753011763	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
438753011764	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
438753011765	FAD binding site [chemical binding]; other site
438753011766	substrate binding pocket [chemical binding]; other site
438753011767	catalytic base [active]
438753011768	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
438753011769	Domain of unknown function (DUF2019); Region: DUF2019; pfam09450
438753011770	Domain of unknown function (DUF2019); Region: DUF2019; pfam09450
438753011771	Domain of unknown function (DUF2019); Region: DUF2019; pfam09450
438753011772	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
438753011773	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
438753011774	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
438753011775	PAS fold; Region: PAS_7; pfam12860
438753011776	PAS fold; Region: PAS_7; pfam12860
438753011777	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753011778	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753011779	metal binding site [ion binding]; metal-binding site
438753011780	active site
438753011781	I-site; other site
438753011782	ethanolamine permease; Region: 2A0305; TIGR00908
438753011783	integrase; Provisional; Region: int; PHA02601
438753011784	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
438753011785	active site
438753011786	DNA binding site [nucleotide binding]
438753011787	Int/Topo IB signature motif; other site
438753011788	seryl-tRNA synthetase; Provisional; Region: PRK05431
438753011789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
438753011790	hypothetical protein; Region: PHA01735
438753011791	Phage T7 tail fibre protein; Region: Phage_T7_tail; pfam03906
438753011792	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
438753011793	catalytic residue [active]
438753011794	apical membrane antigen 1-like protein; Provisional; Region: PTZ00447
438753011795	tail tubular protein A; Region: PHA00428
438753011796	major capsid protein; Region: PHA00201
438753011797	Phage T7 capsid assembly protein; Region: Phage_T7_Capsid; cl14192
438753011798	Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236
438753011799	hypothetical protein; Region: PHA00670
438753011800	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505
438753011801	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
438753011802	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
438753011803	exonuclease; Region: PHA00439
438753011804	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
438753011805	putative active site [active]
438753011806	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
438753011807	putative DNA binding site [nucleotide binding]; other site
438753011808	putative metal binding site [ion binding]; other site
438753011809	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
438753011810	GSH binding site [chemical binding]; other site
438753011811	catalytic residues [active]
438753011812	Thymidylate synthase complementing protein; Region: Thy1; cl03630
438753011813	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
438753011814	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
438753011815	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_B; cd08643
438753011816	active site
438753011817	DNA binding site [nucleotide binding]
438753011818	catalytic site [active]
438753011819	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; pfam08273
438753011820	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
438753011821	active site
438753011822	metal binding site [ion binding]; metal-binding site
438753011823	interdomain interaction site; other site
438753011824	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
438753011825	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
438753011826	Walker A motif; other site
438753011827	ATP binding site [chemical binding]; other site
438753011828	Walker B motif; other site
438753011829	Helix-turn-helix domain; Region: HTH_39; pfam14090
438753011830	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
438753011831	amidase catalytic site [active]
438753011832	Zn binding residues [ion binding]; other site
438753011833	substrate binding site [chemical binding]; other site
438753011834	single-stranded DNA-binding protein; Region: PHA00458
438753011835	Prophage antirepressor [Transcription]; Region: COG3617
438753011836	BRO family, N-terminal domain; Region: Bro-N; smart01040
438753011837	T3/T7-like RNA polymerase; Region: PHA00452
438753011838	Predicted membrane protein [Function unknown]; Region: COG2259
438753011839	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
438753011840	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
438753011841	putative metal binding site [ion binding]; other site
438753011842	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753011843	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
438753011844	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
438753011845	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
438753011846	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
438753011847	catalytic residue [active]
438753011848	FeS assembly protein SufD; Region: sufD; TIGR01981
438753011849	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
438753011850	FeS assembly ATPase SufC; Region: sufC; TIGR01978
438753011851	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
438753011852	Walker A/P-loop; other site
438753011853	ATP binding site [chemical binding]; other site
438753011854	Q-loop/lid; other site
438753011855	ABC transporter signature motif; other site
438753011856	Walker B; other site
438753011857	D-loop; other site
438753011858	H-loop/switch region; other site
438753011859	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
438753011860	putative ABC transporter; Region: ycf24; CHL00085
438753011861	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
438753011862	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
438753011863	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
438753011864	catalytic residue [active]
438753011865	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
438753011866	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
438753011867	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
438753011868	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
438753011869	active site
438753011870	HIGH motif; other site
438753011871	dimer interface [polypeptide binding]; other site
438753011872	KMSKS motif; other site
438753011873	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
438753011874	RNA binding surface [nucleotide binding]; other site
438753011875	Protein of unknown function; Region: DUF3971; pfam13116
438753011876	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
438753011877	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
438753011878	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
438753011879	catalytic triad [active]
438753011880	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
438753011881	SnoaL-like domain; Region: SnoaL_3; pfam13474
438753011882	peptide chain release factor 2; Validated; Region: prfB; PRK00578
438753011883	This domain is found in peptide chain release factors; Region: PCRF; smart00937
438753011884	RF-1 domain; Region: RF-1; pfam00472
438753011885	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
438753011886	Transglycosylase; Region: Transgly; pfam00912
438753011887	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
438753011888	AMIN domain; Region: AMIN; pfam11741
438753011889	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
438753011890	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
438753011891	active site
438753011892	metal binding site [ion binding]; metal-binding site
438753011893	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
438753011894	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
438753011895	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
438753011896	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
438753011897	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
438753011898	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
438753011899	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
438753011900	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
438753011901	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
438753011902	putative active site [active]
438753011903	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
438753011904	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
438753011905	active site
438753011906	dimer interface [polypeptide binding]; other site
438753011907	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
438753011908	dimer interface [polypeptide binding]; other site
438753011909	active site
438753011910	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
438753011911	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753011912	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
438753011913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753011914	putative substrate translocation pore; other site
438753011915	formyl-coenzyme A transferase; Provisional; Region: PRK05398
438753011916	CoA-transferase family III; Region: CoA_transf_3; pfam02515
438753011917	FOG: CBS domain [General function prediction only]; Region: COG0517
438753011918	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
438753011919	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753011920	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753011921	DNA-binding site [nucleotide binding]; DNA binding site
438753011922	FCD domain; Region: FCD; pfam07729
438753011923	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
438753011924	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
438753011925	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
438753011926	catalytic site [active]
438753011927	subunit interface [polypeptide binding]; other site
438753011928	Yqey-like protein; Region: YqeY; pfam09424
438753011929	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
438753011930	Protein of unknown function (DUF497); Region: DUF497; cl01108
438753011931	DNA primase; Validated; Region: dnaG; PRK05667
438753011932	CHC2 zinc finger; Region: zf-CHC2; pfam01807
438753011933	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
438753011934	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
438753011935	active site
438753011936	metal binding site [ion binding]; metal-binding site
438753011937	interdomain interaction site; other site
438753011938	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
438753011939	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
438753011940	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
438753011941	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
438753011942	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
438753011943	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753011944	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
438753011945	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
438753011946	DNA binding residues [nucleotide binding]
438753011947	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753011948	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
438753011949	Autotransporter beta-domain; Region: Autotransporter; pfam03797
438753011950	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
438753011951	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
438753011952	CHASE3 domain; Region: CHASE3; pfam05227
438753011953	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753011954	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753011955	dimer interface [polypeptide binding]; other site
438753011956	phosphorylation site [posttranslational modification]
438753011957	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753011958	ATP binding site [chemical binding]; other site
438753011959	Mg2+ binding site [ion binding]; other site
438753011960	G-X-G motif; other site
438753011961	Response regulator receiver domain; Region: Response_reg; pfam00072
438753011962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753011963	active site
438753011964	phosphorylation site [posttranslational modification]
438753011965	intermolecular recognition site; other site
438753011966	dimerization interface [polypeptide binding]; other site
438753011967	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
438753011968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753011969	active site
438753011970	phosphorylation site [posttranslational modification]
438753011971	intermolecular recognition site; other site
438753011972	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
438753011973	Histidine kinase; Region: HisKA_2; pfam07568
438753011974	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753011975	ATP binding site [chemical binding]; other site
438753011976	Mg2+ binding site [ion binding]; other site
438753011977	G-X-G motif; other site
438753011978	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
438753011979	active site residue [active]
438753011980	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
438753011981	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
438753011982	Switch II region; other site
438753011983	G4 box; other site
438753011984	G5 box; other site
438753011985	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
438753011986	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
438753011987	Malic enzyme, N-terminal domain; Region: malic; pfam00390
438753011988	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
438753011989	putative NAD(P) binding site [chemical binding]; other site
438753011990	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
438753011991	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
438753011992	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
438753011993	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
438753011994	dimer interface [polypeptide binding]; other site
438753011995	anticodon binding site; other site
438753011996	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
438753011997	homodimer interface [polypeptide binding]; other site
438753011998	motif 1; other site
438753011999	active site
438753012000	motif 2; other site
438753012001	GAD domain; Region: GAD; pfam02938
438753012002	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
438753012003	active site
438753012004	motif 3; other site
438753012005	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753012006	metal binding site [ion binding]; metal-binding site
438753012007	active site
438753012008	I-site; other site
438753012009	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753012010	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
438753012011	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
438753012012	catalytic site [active]
438753012013	putative active site [active]
438753012014	putative substrate binding site [chemical binding]; other site
438753012015	HRDC domain; Region: HRDC; pfam00570
438753012016	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
438753012017	iron-sulfur cluster [ion binding]; other site
438753012018	[2Fe-2S] cluster binding site [ion binding]; other site
438753012019	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
438753012020	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
438753012021	polyphosphate kinase; Provisional; Region: PRK05443
438753012022	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
438753012023	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
438753012024	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
438753012025	putative domain interface [polypeptide binding]; other site
438753012026	putative active site [active]
438753012027	catalytic site [active]
438753012028	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
438753012029	putative domain interface [polypeptide binding]; other site
438753012030	putative active site [active]
438753012031	catalytic site [active]
438753012032	hypothetical protein; Provisional; Region: PRK10279
438753012033	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
438753012034	nucleophile elbow; other site
438753012035	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
438753012036	FOG: CBS domain [General function prediction only]; Region: COG0517
438753012037	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
438753012038	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
438753012039	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
438753012040	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
438753012041	trimer interface [polypeptide binding]; other site
438753012042	putative metal binding site [ion binding]; other site
438753012043	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
438753012044	putative active site [active]
438753012045	homotetrameric interface [polypeptide binding]; other site
438753012046	metal binding site [ion binding]; metal-binding site
438753012047	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
438753012048	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
438753012049	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
438753012050	Ligand Binding Site [chemical binding]; other site
438753012051	BolA-like protein; Region: BolA; pfam01722
438753012052	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
438753012053	Chromate transporter; Region: Chromate_transp; pfam02417
438753012054	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
438753012055	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
438753012056	HSP70 interaction site [polypeptide binding]; other site
438753012057	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
438753012058	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
438753012059	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
438753012060	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
438753012061	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
438753012062	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
438753012063	metal ion-dependent adhesion site (MIDAS); other site
438753012064	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
438753012065	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
438753012066	Helix-turn-helix domain; Region: HTH_18; pfam12833
438753012067	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
438753012068	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
438753012069	DNA binding site [nucleotide binding]
438753012070	active site
438753012071	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
438753012072	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
438753012073	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
438753012074	minor groove reading motif; other site
438753012075	helix-hairpin-helix signature motif; other site
438753012076	substrate binding pocket [chemical binding]; other site
438753012077	active site
438753012078	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
438753012079	CysZ-like protein; Reviewed; Region: PRK12768
438753012080	Immunoglobulin domain; Region: Ig; cl11960
438753012081	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
438753012082	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753012083	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753012084	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
438753012085	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
438753012086	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753012087	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753012088	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
438753012089	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
438753012090	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
438753012091	Walker A/P-loop; other site
438753012092	ATP binding site [chemical binding]; other site
438753012093	Q-loop/lid; other site
438753012094	ABC transporter signature motif; other site
438753012095	Walker B; other site
438753012096	D-loop; other site
438753012097	H-loop/switch region; other site
438753012098	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
438753012099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753012100	dimer interface [polypeptide binding]; other site
438753012101	conserved gate region; other site
438753012102	ABC-ATPase subunit interface; other site
438753012103	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
438753012104	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
438753012105	Low affinity iron permease; Region: Iron_permease; pfam04120
438753012106	MAPEG family; Region: MAPEG; cl09190
438753012107	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753012108	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753012109	dimerization interface [polypeptide binding]; other site
438753012110	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
438753012111	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
438753012112	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026
438753012113	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705
438753012114	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
438753012115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753012116	S-adenosylmethionine binding site [chemical binding]; other site
438753012117	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753012118	dimerization interface [polypeptide binding]; other site
438753012119	putative DNA binding site [nucleotide binding]; other site
438753012120	putative Zn2+ binding site [ion binding]; other site
438753012121	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
438753012122	putative hydrophobic ligand binding site [chemical binding]; other site
438753012123	Tellurite resistance protein TerB; Region: TerB; cl17311
438753012124	GMP synthase; Reviewed; Region: guaA; PRK00074
438753012125	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
438753012126	AMP/PPi binding site [chemical binding]; other site
438753012127	candidate oxyanion hole; other site
438753012128	catalytic triad [active]
438753012129	potential glutamine specificity residues [chemical binding]; other site
438753012130	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
438753012131	ATP Binding subdomain [chemical binding]; other site
438753012132	Ligand Binding sites [chemical binding]; other site
438753012133	Dimerization subdomain; other site
438753012134	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
438753012135	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115
438753012136	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
438753012137	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
438753012138	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
438753012139	P loop; other site
438753012140	GTP binding site [chemical binding]; other site
438753012141	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
438753012142	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
438753012143	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753012144	FeS/SAM binding site; other site
438753012145	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
438753012146	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
438753012147	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
438753012148	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
438753012149	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
438753012150	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
438753012151	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
438753012152	enterobactin exporter EntS; Provisional; Region: PRK10489
438753012153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753012154	putative substrate translocation pore; other site
438753012155	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
438753012156	dimerization interface [polypeptide binding]; other site
438753012157	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753012158	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753012159	dimer interface [polypeptide binding]; other site
438753012160	putative CheW interface [polypeptide binding]; other site
438753012161	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
438753012162	IHF dimer interface [polypeptide binding]; other site
438753012163	IHF - DNA interface [nucleotide binding]; other site
438753012164	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
438753012165	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
438753012166	tandem repeat interface [polypeptide binding]; other site
438753012167	oligomer interface [polypeptide binding]; other site
438753012168	active site residues [active]
438753012169	PAS domain; Region: PAS_9; pfam13426
438753012170	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753012171	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753012172	dimer interface [polypeptide binding]; other site
438753012173	putative CheW interface [polypeptide binding]; other site
438753012174	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
438753012175	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
438753012176	RNA binding site [nucleotide binding]; other site
438753012177	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
438753012178	RNA binding site [nucleotide binding]; other site
438753012179	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
438753012180	RNA binding site [nucleotide binding]; other site
438753012181	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
438753012182	RNA binding site [nucleotide binding]; other site
438753012183	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
438753012184	RNA binding site [nucleotide binding]; other site
438753012185	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
438753012186	RNA binding site [nucleotide binding]; other site
438753012187	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
438753012188	Peptidase family M48; Region: Peptidase_M48; pfam01435
438753012189	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753012190	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
438753012191	FeS/SAM binding site; other site
438753012192	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753012193	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753012194	metal binding site [ion binding]; metal-binding site
438753012195	active site
438753012196	I-site; other site
438753012197	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
438753012198	RNA polymerase sigma factor; Provisional; Region: PRK12537
438753012199	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753012200	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
438753012201	DNA binding residues [nucleotide binding]
438753012202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
438753012203	Anti-sigma-K factor rskA; Region: RskA; pfam10099
438753012204	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
438753012205	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
438753012206	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
438753012207	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
438753012208	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
438753012209	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
438753012210	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
438753012211	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
438753012212	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
438753012213	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
438753012214	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753012215	dimer interface [polypeptide binding]; other site
438753012216	conserved gate region; other site
438753012217	putative PBP binding loops; other site
438753012218	ABC-ATPase subunit interface; other site
438753012219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753012220	dimer interface [polypeptide binding]; other site
438753012221	conserved gate region; other site
438753012222	putative PBP binding loops; other site
438753012223	ABC-ATPase subunit interface; other site
438753012224	Protein of unknown function (DUF429); Region: DUF429; cl12046
438753012225	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
438753012226	Uncharacterized conserved small protein [Function unknown]; Region: COG5515
438753012227	Cation efflux family; Region: Cation_efflux; pfam01545
438753012228	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
438753012229	putative active site [active]
438753012230	putative catalytic site [active]
438753012231	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
438753012232	putative active site [active]
438753012233	putative catalytic site [active]
438753012234	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
438753012235	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753012236	putative substrate translocation pore; other site
438753012237	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
438753012238	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
438753012239	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
438753012240	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
438753012241	Iron-sulfur protein interface; other site
438753012242	proximal quinone binding site [chemical binding]; other site
438753012243	SdhD (CybS) interface [polypeptide binding]; other site
438753012244	proximal heme binding site [chemical binding]; other site
438753012245	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
438753012246	putative SdhC subunit interface [polypeptide binding]; other site
438753012247	putative proximal heme binding site [chemical binding]; other site
438753012248	putative Iron-sulfur protein interface [polypeptide binding]; other site
438753012249	putative proximal quinone binding site; other site
438753012250	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
438753012251	L-aspartate oxidase; Provisional; Region: PRK06175
438753012252	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
438753012253	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
438753012254	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
438753012255	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
438753012256	Low molecular weight phosphatase family; Region: LMWPc; cl00105
438753012257	active site
438753012258	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
438753012259	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
438753012260	putative NAD(P) binding site [chemical binding]; other site
438753012261	active site
438753012262	putative substrate binding site [chemical binding]; other site
438753012263	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
438753012264	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
438753012265	NAD binding site [chemical binding]; other site
438753012266	homotetramer interface [polypeptide binding]; other site
438753012267	homodimer interface [polypeptide binding]; other site
438753012268	active site
438753012269	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
438753012270	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
438753012271	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
438753012272	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
438753012273	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
438753012274	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
438753012275	N-terminal plug; other site
438753012276	ligand-binding site [chemical binding]; other site
438753012277	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
438753012278	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753012279	Walker A/P-loop; other site
438753012280	ATP binding site [chemical binding]; other site
438753012281	Q-loop/lid; other site
438753012282	ABC transporter signature motif; other site
438753012283	Walker B; other site
438753012284	D-loop; other site
438753012285	H-loop/switch region; other site
438753012286	Cobalt transport protein; Region: CbiQ; cl00463
438753012287	BioY family; Region: BioY; pfam02632
438753012288	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
438753012289	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
438753012290	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
438753012291	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
438753012292	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
438753012293	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
438753012294	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
438753012295	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
438753012296	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
438753012297	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
438753012298	Walker A/P-loop; other site
438753012299	ATP binding site [chemical binding]; other site
438753012300	Q-loop/lid; other site
438753012301	ABC transporter signature motif; other site
438753012302	Walker B; other site
438753012303	D-loop; other site
438753012304	H-loop/switch region; other site
438753012305	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
438753012306	active site
438753012307	oxyanion hole [active]
438753012308	switch loop; other site
438753012309	catalytic triad [active]
438753012310	PAS domain; Region: PAS_9; pfam13426
438753012311	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753012312	putative active site [active]
438753012313	heme pocket [chemical binding]; other site
438753012314	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753012315	PAS domain; Region: PAS_9; pfam13426
438753012316	putative active site [active]
438753012317	heme pocket [chemical binding]; other site
438753012318	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
438753012319	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
438753012320	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
438753012321	ABC transporter; Region: ABC_tran_2; pfam12848
438753012322	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
438753012323	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
438753012324	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
438753012325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
438753012326	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753012327	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753012328	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753012329	dimerization interface [polypeptide binding]; other site
438753012330	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
438753012331	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
438753012332	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
438753012333	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
438753012334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753012335	dimer interface [polypeptide binding]; other site
438753012336	conserved gate region; other site
438753012337	putative PBP binding loops; other site
438753012338	ABC-ATPase subunit interface; other site
438753012339	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
438753012340	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753012341	putative PBP binding loops; other site
438753012342	dimer interface [polypeptide binding]; other site
438753012343	ABC-ATPase subunit interface; other site
438753012344	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
438753012345	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
438753012346	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
438753012347	active site
438753012348	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
438753012349	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753012350	Walker A/P-loop; other site
438753012351	ATP binding site [chemical binding]; other site
438753012352	Q-loop/lid; other site
438753012353	ABC transporter signature motif; other site
438753012354	Walker B; other site
438753012355	D-loop; other site
438753012356	H-loop/switch region; other site
438753012357	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
438753012358	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
438753012359	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
438753012360	Walker A/P-loop; other site
438753012361	ATP binding site [chemical binding]; other site
438753012362	Q-loop/lid; other site
438753012363	ABC transporter signature motif; other site
438753012364	Walker B; other site
438753012365	D-loop; other site
438753012366	H-loop/switch region; other site
438753012367	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
438753012368	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
438753012369	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
438753012370	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
438753012371	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
438753012372	molybdopterin cofactor binding site; other site
438753012373	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
438753012374	molybdopterin cofactor binding site; other site
438753012375	Killing trait; Region: RebB; pfam11747
438753012376	Killing trait; Region: RebB; pfam11747
438753012377	Killing trait; Region: RebB; pfam11747
438753012378	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
438753012379	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
438753012380	ligand binding site [chemical binding]; other site
438753012381	flexible hinge region; other site
438753012382	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
438753012383	putative switch regulator; other site
438753012384	non-specific DNA interactions [nucleotide binding]; other site
438753012385	DNA binding site [nucleotide binding]
438753012386	sequence specific DNA binding site [nucleotide binding]; other site
438753012387	putative cAMP binding site [chemical binding]; other site
438753012388	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
438753012389	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753012390	S-adenosylmethionine binding site [chemical binding]; other site
438753012391	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
438753012392	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
438753012393	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
438753012394	ABC transporter; Region: ABC_tran_2; pfam12848
438753012395	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
438753012396	Cupin domain; Region: Cupin_2; cl17218
438753012397	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753012398	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753012399	The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462
438753012400	putative substrate binding pocket [chemical binding]; other site
438753012401	putative dimerization interface [polypeptide binding]; other site
438753012402	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
438753012403	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
438753012404	conserved cys residue [active]
438753012405	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753012406	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
438753012407	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
438753012408	nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323
438753012409	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
438753012410	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
438753012411	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
438753012412	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
438753012413	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
438753012414	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
438753012415	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
438753012416	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
438753012417	leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011
438753012418	Winged helix-turn helix; Region: HTH_29; pfam13551
438753012419	Homeodomain-like domain; Region: HTH_32; pfam13565
438753012420	Integrase core domain; Region: rve; pfam00665
438753012421	Integrase core domain; Region: rve_3; pfam13683
438753012422	Lysine efflux permease [General function prediction only]; Region: COG1279
438753012423	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
438753012424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753012425	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753012426	dimerization interface [polypeptide binding]; other site
438753012427	DDE superfamily endonuclease; Region: DDE_5; pfam13546
438753012428	DDE superfamily endonuclease; Region: DDE_5; cl17874
438753012429	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
438753012430	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
438753012431	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
438753012432	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
438753012433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753012434	NAD(P) binding site [chemical binding]; other site
438753012435	active site
438753012436	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
438753012437	FAD binding domain; Region: FAD_binding_4; pfam01565
438753012438	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
438753012439	Alpha 1,6-fucosyltransferase similar to Bradyrhizobium NodZ; Region: NodZ_like; cd11548
438753012440	GDP-Fucose binding site [chemical binding]; other site
438753012441	ABC-2 type transporter, NodJ family; Region: nodJ; TIGR01291
438753012442	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
438753012443	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
438753012444	Walker A/P-loop; other site
438753012445	ATP binding site [chemical binding]; other site
438753012446	Q-loop/lid; other site
438753012447	ABC transporter signature motif; other site
438753012448	Walker B; other site
438753012449	D-loop; other site
438753012450	H-loop/switch region; other site
438753012451	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
438753012452	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
438753012453	Methyltransferase domain; Region: Methyltransf_23; pfam13489
438753012454	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753012455	S-adenosylmethionine binding site [chemical binding]; other site
438753012456	chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242
438753012457	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
438753012458	active site
438753012459	Putative catalytic domain of rhizobial NodB chitooligosaccharide N-deacetylase and its bacterial homologs; Region: CE4_NodB; cd10943
438753012460	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
438753012461	NodB motif; other site
438753012462	putative active site [active]
438753012463	putative catalytic site [active]
438753012464	putative Zn binding site [ion binding]; other site
438753012465	acyltransferase NodA; Provisional; Region: PRK00756
438753012466	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
438753012467	Transposase, Mutator family; Region: Transposase_mut; pfam00872
438753012468	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
438753012469	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
438753012470	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
438753012471	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
438753012472	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
438753012473	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
438753012474	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
438753012475	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
438753012476	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
438753012477	Walker A motif; other site
438753012478	ATP binding site [chemical binding]; other site
438753012479	Walker B motif; other site
438753012480	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
438753012481	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
438753012482	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
438753012483	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
438753012484	N-acetyl-D-glucosamine binding site [chemical binding]; other site
438753012485	catalytic residue [active]
438753012486	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
438753012487	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
438753012488	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
438753012489	ParA-like protein; Provisional; Region: PHA02518
438753012490	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
438753012491	P-loop; other site
438753012492	Magnesium ion binding site [ion binding]; other site
438753012493	Replication initiator protein A; Region: RPA; pfam10134
438753012494	Helix-turn-helix domain; Region: HTH_17; pfam12728
438753012495	Uncharacterized conserved protein [Function unknown]; Region: COG5489
438753012496	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
438753012497	oligomeric interface; other site
438753012498	putative active site [active]
438753012499	homodimer interface [polypeptide binding]; other site
438753012500	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
438753012501	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
438753012502	Toprim domain; Region: Toprim_3; pfam13362
438753012503	ParB-like nuclease domain; Region: ParB; smart00470
438753012504	leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011
438753012505	Winged helix-turn helix; Region: HTH_29; pfam13551
438753012506	Homeodomain-like domain; Region: HTH_32; pfam13565
438753012507	Integrase core domain; Region: rve; pfam00665
438753012508	Integrase core domain; Region: rve_3; pfam13683
438753012509	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753012510	dimerization interface [polypeptide binding]; other site
438753012511	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753012512	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753012513	dimer interface [polypeptide binding]; other site
438753012514	putative CheW interface [polypeptide binding]; other site
438753012515	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
438753012516	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
438753012517	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
438753012518	NADP binding site [chemical binding]; other site
438753012519	active site
438753012520	putative substrate binding site [chemical binding]; other site
438753012521	Transposase, Mutator family; Region: Transposase_mut; pfam00872
438753012522	Transposase; Region: HTH_Tnp_1; pfam01527
438753012523	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
438753012524	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
438753012525	Integrase core domain; Region: rve_3; pfam13683
438753012526	Fic family protein [Function unknown]; Region: COG3177
438753012527	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
438753012528	Fic/DOC family; Region: Fic; pfam02661
438753012529	EVE domain; Region: EVE; cl00728
438753012530	HNH endonuclease; Region: HNH_2; pfam13391
438753012531	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
438753012532	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
438753012533	ATP binding site [chemical binding]; other site
438753012534	Walker A motif; other site
438753012535	hexamer interface [polypeptide binding]; other site
438753012536	Walker B motif; other site
438753012537	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
438753012538	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
438753012539	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
438753012540	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
438753012541	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753012542	Walker A/P-loop; other site
438753012543	ATP binding site [chemical binding]; other site
438753012544	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
438753012545	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
438753012546	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
438753012547	conjugal transfer protein TrbL; Provisional; Region: PRK13875
438753012548	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
438753012549	conjugal transfer protein TrbF; Provisional; Region: PRK13872
438753012550	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
438753012551	VirB7 interaction site; other site
438753012552	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
438753012553	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
438753012554	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753012555	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
438753012556	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753012557	dimerization interface [polypeptide binding]; other site
438753012558	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753012559	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753012560	substrate binding pocket [chemical binding]; other site
438753012561	membrane-bound complex binding site; other site
438753012562	hinge residues; other site
438753012563	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753012564	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753012565	dimer interface [polypeptide binding]; other site
438753012566	conserved gate region; other site
438753012567	putative PBP binding loops; other site
438753012568	ABC-ATPase subunit interface; other site
438753012569	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753012570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753012571	dimer interface [polypeptide binding]; other site
438753012572	conserved gate region; other site
438753012573	putative PBP binding loops; other site
438753012574	ABC-ATPase subunit interface; other site
438753012575	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
438753012576	active sites [active]
438753012577	argininosuccinate lyase; Provisional; Region: PRK00855
438753012578	tetramer interface [polypeptide binding]; other site
438753012579	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753012580	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753012581	Walker A/P-loop; other site
438753012582	ATP binding site [chemical binding]; other site
438753012583	Q-loop/lid; other site
438753012584	ABC transporter signature motif; other site
438753012585	Walker B; other site
438753012586	D-loop; other site
438753012587	H-loop/switch region; other site
438753012588	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753012589	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753012590	Walker A/P-loop; other site
438753012591	ATP binding site [chemical binding]; other site
438753012592	Q-loop/lid; other site
438753012593	ABC transporter signature motif; other site
438753012594	Walker B; other site
438753012595	D-loop; other site
438753012596	H-loop/switch region; other site
438753012597	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
438753012598	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
438753012599	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
438753012600	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
438753012601	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753012602	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
438753012603	dimerization interface [polypeptide binding]; other site
438753012604	substrate binding pocket [chemical binding]; other site
438753012605	leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011
438753012606	Winged helix-turn helix; Region: HTH_29; pfam13551
438753012607	Homeodomain-like domain; Region: HTH_32; pfam13565
438753012608	Integrase core domain; Region: rve; pfam00665
438753012609	Integrase core domain; Region: rve_3; pfam13683
438753012610	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
438753012611	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
438753012612	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753012613	non-specific DNA binding site [nucleotide binding]; other site
438753012614	salt bridge; other site
438753012615	sequence-specific DNA binding site [nucleotide binding]; other site
438753012616	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
438753012617	active site
438753012618	DNA binding site [nucleotide binding]
438753012619	Int/Topo IB signature motif; other site
438753012620	Predicted amidohydrolase [General function prediction only]; Region: COG0388
438753012621	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
438753012622	active site
438753012623	catalytic triad [active]
438753012624	dimer interface [polypeptide binding]; other site
438753012625	Second nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R2; cd07579
438753012626	Predicted amidohydrolase [General function prediction only]; Region: COG0388
438753012627	putative active site [active]
438753012628	catalytic triad [active]
438753012629	putative dimer interface [polypeptide binding]; other site
438753012630	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
438753012631	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753012632	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753012633	Walker A/P-loop; other site
438753012634	ATP binding site [chemical binding]; other site
438753012635	Q-loop/lid; other site
438753012636	ABC transporter signature motif; other site
438753012637	Walker B; other site
438753012638	D-loop; other site
438753012639	H-loop/switch region; other site
438753012640	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
438753012641	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753012642	Walker A/P-loop; other site
438753012643	ATP binding site [chemical binding]; other site
438753012644	Q-loop/lid; other site
438753012645	ABC transporter signature motif; other site
438753012646	Walker B; other site
438753012647	D-loop; other site
438753012648	H-loop/switch region; other site
438753012649	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753012650	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753012651	TM-ABC transporter signature motif; other site
438753012652	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753012653	TM-ABC transporter signature motif; other site
438753012654	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753012655	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356
438753012656	putative ligand binding site [chemical binding]; other site
438753012657	ANTAR domain; Region: ANTAR; pfam03861
438753012658	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
438753012659	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753012660	ligand binding site [chemical binding]; other site
438753012661	regulator interaction site; other site
438753012662	Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; cl17559
438753012663	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
438753012664	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753012665	active site
438753012666	NMT1/THI5 like; Region: NMT1; pfam09084
438753012667	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753012668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753012669	dimer interface [polypeptide binding]; other site
438753012670	conserved gate region; other site
438753012671	putative PBP binding loops; other site
438753012672	ABC-ATPase subunit interface; other site
438753012673	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753012674	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753012675	Walker A/P-loop; other site
438753012676	ATP binding site [chemical binding]; other site
438753012677	Q-loop/lid; other site
438753012678	ABC transporter signature motif; other site
438753012679	Walker B; other site
438753012680	D-loop; other site
438753012681	H-loop/switch region; other site
438753012682	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
438753012683	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753012684	active site
438753012685	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
438753012686	classical (c) SDRs; Region: SDR_c; cd05233
438753012687	NAD(P) binding site [chemical binding]; other site
438753012688	active site
438753012689	NMT1/THI5 like; Region: NMT1; pfam09084
438753012690	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753012691	substrate binding pocket [chemical binding]; other site
438753012692	membrane-bound complex binding site; other site
438753012693	hinge residues; other site
438753012694	Isochorismatase family; Region: Isochorismatase; pfam00857
438753012695	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
438753012696	catalytic triad [active]
438753012697	conserved cis-peptide bond; other site
438753012698	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753012699	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753012700	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753012701	dimerization interface [polypeptide binding]; other site
438753012702	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753012703	putative acyltransferase; Provisional; Region: PRK05790
438753012704	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
438753012705	dimer interface [polypeptide binding]; other site
438753012706	active site
438753012707	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
438753012708	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
438753012709	active site
438753012710	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
438753012711	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
438753012712	generic binding surface I; other site
438753012713	generic binding surface II; other site
438753012714	DNA Polymerase Y-family; Region: PolY_like; cd03468
438753012715	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
438753012716	DNA binding site [nucleotide binding]
438753012717	Uncharacterized conserved protein [Function unknown]; Region: COG4544
438753012718	Staphylococcal nuclease homologues; Region: SNc; smart00318
438753012719	Catalytic site; other site
438753012720	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
438753012721	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753012722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753012723	dimer interface [polypeptide binding]; other site
438753012724	phosphorylation site [posttranslational modification]
438753012725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753012726	ATP binding site [chemical binding]; other site
438753012727	Mg2+ binding site [ion binding]; other site
438753012728	G-X-G motif; other site
438753012729	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
438753012730	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
438753012731	putative dimer interface [polypeptide binding]; other site
438753012732	active site pocket [active]
438753012733	putative cataytic base [active]
438753012734	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
438753012735	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
438753012736	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753012737	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753012738	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
438753012739	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
438753012740	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
438753012741	Flavoprotein; Region: Flavoprotein; pfam02441
438753012742	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
438753012743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753012744	PAS domain; Region: PAS_9; pfam13426
438753012745	putative active site [active]
438753012746	heme pocket [chemical binding]; other site
438753012747	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753012748	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753012749	metal binding site [ion binding]; metal-binding site
438753012750	active site
438753012751	I-site; other site
438753012752	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753012753	active site
438753012754	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
438753012755	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
438753012756	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
438753012757	ABC1 family; Region: ABC1; cl17513
438753012758	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
438753012759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753012760	S-adenosylmethionine binding site [chemical binding]; other site
438753012761	CAAX protease self-immunity; Region: Abi; cl00558
438753012762	CAAX protease self-immunity; Region: Abi; pfam02517
438753012763	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
438753012764	Na binding site [ion binding]; other site
438753012765	PAS fold; Region: PAS_7; pfam12860
438753012766	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753012767	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753012768	dimer interface [polypeptide binding]; other site
438753012769	phosphorylation site [posttranslational modification]
438753012770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753012771	ATP binding site [chemical binding]; other site
438753012772	Mg2+ binding site [ion binding]; other site
438753012773	G-X-G motif; other site
438753012774	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
438753012775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753012776	active site
438753012777	phosphorylation site [posttranslational modification]
438753012778	intermolecular recognition site; other site
438753012779	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
438753012780	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
438753012781	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
438753012782	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
438753012783	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
438753012784	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
438753012785	Walker A/P-loop; other site
438753012786	ATP binding site [chemical binding]; other site
438753012787	Q-loop/lid; other site
438753012788	ABC transporter signature motif; other site
438753012789	Walker B; other site
438753012790	D-loop; other site
438753012791	H-loop/switch region; other site
438753012792	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
438753012793	OstA-like protein; Region: OstA; pfam03968
438753012794	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
438753012795	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
438753012796	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
438753012797	catalytic site [active]
438753012798	putative active site [active]
438753012799	putative substrate binding site [chemical binding]; other site
438753012800	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
438753012801	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
438753012802	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
438753012803	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
438753012804	hinge; other site
438753012805	active site
438753012806	cytidylate kinase; Provisional; Region: cmk; PRK00023
438753012807	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
438753012808	CMP-binding site; other site
438753012809	The sites determining sugar specificity; other site
438753012810	Protein of unknown function (DUF1636); Region: DUF1636; cl17843
438753012811	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
438753012812	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
438753012813	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
438753012814	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
438753012815	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
438753012816	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
438753012817	precorrin-3B synthase; Region: CobG; TIGR02435
438753012818	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
438753012819	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
438753012820	Precorrin-8X methylmutase; Region: CbiC; pfam02570
438753012821	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
438753012822	active site
438753012823	SAM binding site [chemical binding]; other site
438753012824	homodimer interface [polypeptide binding]; other site
438753012825	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
438753012826	active site
438753012827	SAM binding site [chemical binding]; other site
438753012828	homodimer interface [polypeptide binding]; other site
438753012829	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
438753012830	active site
438753012831	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
438753012832	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
438753012833	active site
438753012834	putative homodimer interface [polypeptide binding]; other site
438753012835	SAM binding site [chemical binding]; other site
438753012836	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
438753012837	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
438753012838	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
438753012839	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
438753012840	active site
438753012841	SAM binding site [chemical binding]; other site
438753012842	homodimer interface [polypeptide binding]; other site
438753012843	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
438753012844	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
438753012845	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
438753012846	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
438753012847	succinic semialdehyde dehydrogenase; Region: PLN02278
438753012848	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
438753012849	tetramerization interface [polypeptide binding]; other site
438753012850	NAD(P) binding site [chemical binding]; other site
438753012851	catalytic residues [active]
438753012852	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
438753012853	signal recognition particle protein; Provisional; Region: PRK10867
438753012854	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
438753012855	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
438753012856	P loop; other site
438753012857	GTP binding site [chemical binding]; other site
438753012858	Signal peptide binding domain; Region: SRP_SPB; pfam02978
438753012859	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
438753012860	RimM N-terminal domain; Region: RimM; pfam01782
438753012861	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
438753012862	PRC-barrel domain; Region: PRC; pfam05239
438753012863	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
438753012864	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
438753012865	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
438753012866	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
438753012867	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
438753012868	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
438753012869	putative dimer interface [polypeptide binding]; other site
438753012870	N-terminal domain interface [polypeptide binding]; other site
438753012871	putative substrate binding pocket (H-site) [chemical binding]; other site
438753012872	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
438753012873	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
438753012874	inhibitor-cofactor binding pocket; inhibition site
438753012875	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753012876	catalytic residue [active]
438753012877	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
438753012878	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
438753012879	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
438753012880	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
438753012881	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
438753012882	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
438753012883	Mechanosensitive ion channel; Region: MS_channel; pfam00924
438753012884	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
438753012885	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
438753012886	ligand binding site [chemical binding]; other site
438753012887	flexible hinge region; other site
438753012888	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753012889	dimerization interface [polypeptide binding]; other site
438753012890	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
438753012891	cyclase homology domain; Region: CHD; cd07302
438753012892	nucleotidyl binding site; other site
438753012893	metal binding site [ion binding]; metal-binding site
438753012894	dimer interface [polypeptide binding]; other site
438753012895	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
438753012896	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
438753012897	GIY-YIG motif/motif A; other site
438753012898	active site
438753012899	catalytic site [active]
438753012900	putative DNA binding site [nucleotide binding]; other site
438753012901	metal binding site [ion binding]; metal-binding site
438753012902	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
438753012903	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
438753012904	Helix-hairpin-helix motif; Region: HHH; pfam00633
438753012905	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
438753012906	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
438753012907	MoaE interaction surface [polypeptide binding]; other site
438753012908	MoeB interaction surface [polypeptide binding]; other site
438753012909	thiocarboxylated glycine; other site
438753012910	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
438753012911	MoaE homodimer interface [polypeptide binding]; other site
438753012912	MoaD interaction [polypeptide binding]; other site
438753012913	active site residues [active]
438753012914	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753012915	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753012916	metal binding site [ion binding]; metal-binding site
438753012917	active site
438753012918	I-site; other site
438753012919	Cache domain; Region: Cache_1; pfam02743
438753012920	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753012921	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753012922	metal binding site [ion binding]; metal-binding site
438753012923	active site
438753012924	I-site; other site
438753012925	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
438753012926	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
438753012927	homodimer interface [polypeptide binding]; other site
438753012928	substrate-cofactor binding pocket; other site
438753012929	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753012930	catalytic residue [active]
438753012931	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
438753012932	MarR family; Region: MarR_2; pfam12802
438753012933	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753012934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753012935	active site
438753012936	phosphorylation site [posttranslational modification]
438753012937	intermolecular recognition site; other site
438753012938	dimerization interface [polypeptide binding]; other site
438753012939	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753012940	DNA binding site [nucleotide binding]
438753012941	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753012942	HAMP domain; Region: HAMP; pfam00672
438753012943	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753012944	dimer interface [polypeptide binding]; other site
438753012945	phosphorylation site [posttranslational modification]
438753012946	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753012947	ATP binding site [chemical binding]; other site
438753012948	Mg2+ binding site [ion binding]; other site
438753012949	G-X-G motif; other site
438753012950	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753012951	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
438753012952	Coenzyme A binding pocket [chemical binding]; other site
438753012953	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
438753012954	dimer interface [polypeptide binding]; other site
438753012955	putative tRNA-binding site [nucleotide binding]; other site
438753012956	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
438753012957	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
438753012958	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
438753012959	Membrane fusogenic activity; Region: BMFP; pfam04380
438753012960	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
438753012961	Uncharacterized conserved protein [Function unknown]; Region: COG1565
438753012962	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
438753012963	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
438753012964	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753012965	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753012966	active site
438753012967	phosphorylation site [posttranslational modification]
438753012968	intermolecular recognition site; other site
438753012969	dimerization interface [polypeptide binding]; other site
438753012970	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753012971	DNA binding site [nucleotide binding]
438753012972	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753012973	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753012974	dimerization interface [polypeptide binding]; other site
438753012975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753012976	ATP binding site [chemical binding]; other site
438753012977	Mg2+ binding site [ion binding]; other site
438753012978	G-X-G motif; other site
438753012979	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
438753012980	ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615
438753012981	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
438753012982	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753012983	Walker A/P-loop; other site
438753012984	ATP binding site [chemical binding]; other site
438753012985	Q-loop/lid; other site
438753012986	ABC transporter signature motif; other site
438753012987	Walker B; other site
438753012988	D-loop; other site
438753012989	H-loop/switch region; other site
438753012990	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
438753012991	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
438753012992	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
438753012993	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
438753012994	inhibitor-cofactor binding pocket; inhibition site
438753012995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753012996	catalytic residue [active]
438753012997	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
438753012998	Esterase/lipase [General function prediction only]; Region: COG1647
438753012999	Esterase/lipase [General function prediction only]; Region: COG1647
438753013000	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
438753013001	DevC protein; Region: devC; TIGR01185
438753013002	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
438753013003	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
438753013004	Walker A/P-loop; other site
438753013005	ATP binding site [chemical binding]; other site
438753013006	Q-loop/lid; other site
438753013007	ABC transporter signature motif; other site
438753013008	Walker B; other site
438753013009	D-loop; other site
438753013010	H-loop/switch region; other site
438753013011	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
438753013012	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
438753013013	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753013014	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
438753013015	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
438753013016	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
438753013017	active site
438753013018	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
438753013019	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
438753013020	active site
438753013021	hypothetical protein; Validated; Region: PRK00124
438753013022	MAPEG family; Region: MAPEG; cl09190
438753013023	Predicted transcriptional regulators [Transcription]; Region: COG1695
438753013024	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
438753013025	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
438753013026	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
438753013027	active site
438753013028	DNA binding site [nucleotide binding]
438753013029	Int/Topo IB signature motif; other site
438753013030	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
438753013031	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
438753013032	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753013033	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
438753013034	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
438753013035	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
438753013036	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
438753013037	LysE type translocator; Region: LysE; cl00565
438753013038	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
438753013039	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
438753013040	E3 interaction surface; other site
438753013041	lipoyl attachment site [posttranslational modification]; other site
438753013042	e3 binding domain; Region: E3_binding; pfam02817
438753013043	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
438753013044	YCII-related domain; Region: YCII; cl00999
438753013045	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
438753013046	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
438753013047	TPP-binding site [chemical binding]; other site
438753013048	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
438753013049	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
438753013050	CoA binding domain; Region: CoA_binding; smart00881
438753013051	CoA-ligase; Region: Ligase_CoA; pfam00549
438753013052	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
438753013053	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
438753013054	CoA-ligase; Region: Ligase_CoA; pfam00549
438753013055	malate dehydrogenase; Reviewed; Region: PRK06223
438753013056	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
438753013057	NAD(P) binding site [chemical binding]; other site
438753013058	dimer interface [polypeptide binding]; other site
438753013059	tetramer (dimer of dimers) interface [polypeptide binding]; other site
438753013060	substrate binding site [chemical binding]; other site
438753013061	Predicted ATPase [General function prediction only]; Region: COG1485
438753013062	Predicted membrane protein [Function unknown]; Region: COG1289
438753013063	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
438753013064	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
438753013065	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
438753013066	trimer interface [polypeptide binding]; other site
438753013067	active site
438753013068	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
438753013069	trimer interface [polypeptide binding]; other site
438753013070	active site
438753013071	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
438753013072	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
438753013073	homodimer interface [polypeptide binding]; other site
438753013074	substrate-cofactor binding pocket; other site
438753013075	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753013076	catalytic residue [active]
438753013077	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
438753013078	DctM-like transporters; Region: DctM; pfam06808
438753013079	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
438753013080	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
438753013081	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
438753013082	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
438753013083	dimerization interface [polypeptide binding]; other site
438753013084	domain crossover interface; other site
438753013085	redox-dependent activation switch; other site
438753013086	ornithine carbamoyltransferase; Provisional; Region: PRK00779
438753013087	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
438753013088	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
438753013089	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
438753013090	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
438753013091	inhibitor-cofactor binding pocket; inhibition site
438753013092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753013093	catalytic residue [active]
438753013094	GcrA cell cycle regulator; Region: GcrA; cl11564
438753013095	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
438753013096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753013097	active site
438753013098	phosphorylation site [posttranslational modification]
438753013099	intermolecular recognition site; other site
438753013100	dimerization interface [polypeptide binding]; other site
438753013101	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753013102	DNA binding site [nucleotide binding]
438753013103	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
438753013104	PhoU domain; Region: PhoU; pfam01895
438753013105	PhoU domain; Region: PhoU; pfam01895
438753013106	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
438753013107	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
438753013108	Walker A/P-loop; other site
438753013109	ATP binding site [chemical binding]; other site
438753013110	Q-loop/lid; other site
438753013111	ABC transporter signature motif; other site
438753013112	Walker B; other site
438753013113	D-loop; other site
438753013114	H-loop/switch region; other site
438753013115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753013116	dimer interface [polypeptide binding]; other site
438753013117	conserved gate region; other site
438753013118	putative PBP binding loops; other site
438753013119	ABC-ATPase subunit interface; other site
438753013120	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753013121	dimer interface [polypeptide binding]; other site
438753013122	conserved gate region; other site
438753013123	putative PBP binding loops; other site
438753013124	ABC-ATPase subunit interface; other site
438753013125	PBP superfamily domain; Region: PBP_like_2; cl17296
438753013126	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753013127	dimer interface [polypeptide binding]; other site
438753013128	phosphorylation site [posttranslational modification]
438753013129	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753013130	ATP binding site [chemical binding]; other site
438753013131	Mg2+ binding site [ion binding]; other site
438753013132	G-X-G motif; other site
438753013133	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
438753013134	Predicted integral membrane protein [Function unknown]; Region: COG0392
438753013135	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
438753013136	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
438753013137	homotetramer interface [polypeptide binding]; other site
438753013138	ligand binding site [chemical binding]; other site
438753013139	catalytic site [active]
438753013140	NAD binding site [chemical binding]; other site
438753013141	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
438753013142	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
438753013143	DNA-binding site [nucleotide binding]; DNA binding site
438753013144	RNA-binding motif; other site
438753013145	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
438753013146	DNA-binding site [nucleotide binding]; DNA binding site
438753013147	RNA-binding motif; other site
438753013148	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
438753013149	putative FMN binding site [chemical binding]; other site
438753013150	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
438753013151	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
438753013152	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
438753013153	G1 box; other site
438753013154	GTP/Mg2+ binding site [chemical binding]; other site
438753013155	Switch I region; other site
438753013156	G2 box; other site
438753013157	G3 box; other site
438753013158	Switch II region; other site
438753013159	G4 box; other site
438753013160	G5 box; other site
438753013161	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
438753013162	YceI-like domain; Region: YceI; pfam04264
438753013163	membrane protein insertase; Provisional; Region: PRK01318
438753013164	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
438753013165	Ribonuclease P; Region: Ribonuclease_P; cl00457
438753013166	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
438753013167	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
438753013168	putative cation:proton antiport protein; Provisional; Region: PRK10669
438753013169	TrkA-N domain; Region: TrkA_N; pfam02254
438753013170	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
438753013171	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
438753013172	substrate binding site [chemical binding]; other site
438753013173	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
438753013174	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
438753013175	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
438753013176	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
438753013177	substrate binding site [chemical binding]; other site
438753013178	ligand binding site [chemical binding]; other site
438753013179	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
438753013180	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
438753013181	active site
438753013182	substrate-binding site [chemical binding]; other site
438753013183	metal-binding site [ion binding]
438753013184	ATP binding site [chemical binding]; other site
438753013185	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
438753013186	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
438753013187	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
438753013188	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753013189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753013190	active site
438753013191	phosphorylation site [posttranslational modification]
438753013192	intermolecular recognition site; other site
438753013193	dimerization interface [polypeptide binding]; other site
438753013194	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753013195	DNA binding site [nucleotide binding]
438753013196	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
438753013197	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
438753013198	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
438753013199	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753013200	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753013201	dimer interface [polypeptide binding]; other site
438753013202	phosphorylation site [posttranslational modification]
438753013203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753013204	ATP binding site [chemical binding]; other site
438753013205	Mg2+ binding site [ion binding]; other site
438753013206	G-X-G motif; other site
438753013207	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
438753013208	Hpr binding site; other site
438753013209	active site
438753013210	homohexamer subunit interaction site [polypeptide binding]; other site
438753013211	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
438753013212	active pocket/dimerization site; other site
438753013213	active site
438753013214	phosphorylation site [posttranslational modification]
438753013215	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
438753013216	regulatory protein interface [polypeptide binding]; other site
438753013217	active site
438753013218	regulatory phosphorylation site [posttranslational modification]; other site
438753013219	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753013220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753013221	ATP binding site [chemical binding]; other site
438753013222	Mg2+ binding site [ion binding]; other site
438753013223	G-X-G motif; other site
438753013224	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
438753013225	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
438753013226	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
438753013227	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
438753013228	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
438753013229	putative active site [active]
438753013230	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753013231	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753013232	Walker A/P-loop; other site
438753013233	ATP binding site [chemical binding]; other site
438753013234	Q-loop/lid; other site
438753013235	ABC transporter signature motif; other site
438753013236	Walker B; other site
438753013237	D-loop; other site
438753013238	H-loop/switch region; other site
438753013239	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753013240	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753013241	Walker A/P-loop; other site
438753013242	ATP binding site [chemical binding]; other site
438753013243	Q-loop/lid; other site
438753013244	ABC transporter signature motif; other site
438753013245	Walker B; other site
438753013246	D-loop; other site
438753013247	H-loop/switch region; other site
438753013248	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753013249	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753013250	TM-ABC transporter signature motif; other site
438753013251	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753013252	TM-ABC transporter signature motif; other site
438753013253	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
438753013254	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340
438753013255	putative ligand binding site [chemical binding]; other site
438753013256	hypothetical protein; Provisional; Region: PRK05463
438753013257	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753013258	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753013259	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
438753013260	dimerization interface [polypeptide binding]; other site
438753013261	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
438753013262	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
438753013263	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
438753013264	PAS domain; Region: PAS_9; pfam13426
438753013265	PAS domain; Region: PAS_9; pfam13426
438753013266	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
438753013267	putative active site [active]
438753013268	heme pocket [chemical binding]; other site
438753013269	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753013270	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753013271	metal binding site [ion binding]; metal-binding site
438753013272	active site
438753013273	I-site; other site
438753013274	Predicted ATPase [General function prediction only]; Region: COG3911
438753013275	AAA domain; Region: AAA_28; pfam13521
438753013276	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
438753013277	diiron binding motif [ion binding]; other site
438753013278	Uncharacterized conserved protein [Function unknown]; Region: COG1633
438753013279	CCC1-related family of proteins; Region: CCC1_like; cl00278
438753013280	Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450
438753013281	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
438753013282	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
438753013283	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
438753013284	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
438753013285	putative active site [active]
438753013286	Ap4A binding site [chemical binding]; other site
438753013287	nudix motif; other site
438753013288	putative metal binding site [ion binding]; other site
438753013289	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
438753013290	putative active site [active]
438753013291	putative metal binding site [ion binding]; other site
438753013292	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
438753013293	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
438753013294	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
438753013295	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
438753013296	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
438753013297	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
438753013298	PAS domain S-box; Region: sensory_box; TIGR00229
438753013299	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753013300	putative active site [active]
438753013301	heme pocket [chemical binding]; other site
438753013302	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753013303	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753013304	metal binding site [ion binding]; metal-binding site
438753013305	active site
438753013306	I-site; other site
438753013307	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
438753013308	dimerization interface [polypeptide binding]; other site
438753013309	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753013310	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753013311	dimer interface [polypeptide binding]; other site
438753013312	putative CheW interface [polypeptide binding]; other site
438753013313	Methyltransferase domain; Region: Methyltransf_11; pfam08241
438753013314	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
438753013315	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
438753013316	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
438753013317	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
438753013318	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
438753013319	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753013320	Walker A/P-loop; other site
438753013321	ATP binding site [chemical binding]; other site
438753013322	Q-loop/lid; other site
438753013323	ABC transporter signature motif; other site
438753013324	Walker B; other site
438753013325	D-loop; other site
438753013326	H-loop/switch region; other site
438753013327	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
438753013328	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753013329	Walker A/P-loop; other site
438753013330	ATP binding site [chemical binding]; other site
438753013331	Q-loop/lid; other site
438753013332	ABC transporter signature motif; other site
438753013333	Walker B; other site
438753013334	D-loop; other site
438753013335	H-loop/switch region; other site
438753013336	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753013337	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753013338	TM-ABC transporter signature motif; other site
438753013339	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753013340	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753013341	TM-ABC transporter signature motif; other site
438753013342	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753013343	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
438753013344	putative ligand binding site [chemical binding]; other site
438753013345	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
438753013346	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753013347	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753013348	dimer interface [polypeptide binding]; other site
438753013349	phosphorylation site [posttranslational modification]
438753013350	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753013351	ATP binding site [chemical binding]; other site
438753013352	Mg2+ binding site [ion binding]; other site
438753013353	G-X-G motif; other site
438753013354	Response regulator receiver domain; Region: Response_reg; pfam00072
438753013355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753013356	active site
438753013357	phosphorylation site [posttranslational modification]
438753013358	intermolecular recognition site; other site
438753013359	dimerization interface [polypeptide binding]; other site
438753013360	Response regulator receiver domain; Region: Response_reg; pfam00072
438753013361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753013362	active site
438753013363	phosphorylation site [posttranslational modification]
438753013364	intermolecular recognition site; other site
438753013365	dimerization interface [polypeptide binding]; other site
438753013366	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
438753013367	DNA binding residues [nucleotide binding]
438753013368	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
438753013369	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753013370	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
438753013371	DNA binding residues [nucleotide binding]
438753013372	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
438753013373	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
438753013374	tyrosine decarboxylase; Region: PLN02880
438753013375	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
438753013376	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
438753013377	catalytic residue [active]
438753013378	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
438753013379	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
438753013380	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
438753013381	ABC transporter; Region: ABC_tran_2; pfam12848
438753013382	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
438753013383	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
438753013384	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
438753013385	active site
438753013386	catalytic site [active]
438753013387	trehalose synthase; Region: treS_nterm; TIGR02456
438753013388	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
438753013389	active site
438753013390	catalytic site [active]
438753013391	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
438753013392	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
438753013393	glycogen branching enzyme; Provisional; Region: PRK05402
438753013394	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
438753013395	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
438753013396	active site
438753013397	catalytic site [active]
438753013398	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
438753013399	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
438753013400	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
438753013401	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
438753013402	tetrameric interface [polypeptide binding]; other site
438753013403	NAD binding site [chemical binding]; other site
438753013404	catalytic residues [active]
438753013405	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753013406	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753013407	LysR substrate binding domain; Region: LysR_substrate; pfam03466
438753013408	dimerization interface [polypeptide binding]; other site
438753013409	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
438753013410	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
438753013411	dimerization interface [polypeptide binding]; other site
438753013412	DPS ferroxidase diiron center [ion binding]; other site
438753013413	ion pore; other site
438753013414	EamA-like transporter family; Region: EamA; pfam00892
438753013415	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
438753013416	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753013417	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753013418	LysR substrate binding domain; Region: LysR_substrate; pfam03466
438753013419	dimerization interface [polypeptide binding]; other site
438753013420	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
438753013421	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
438753013422	gamma subunit interface [polypeptide binding]; other site
438753013423	epsilon subunit interface [polypeptide binding]; other site
438753013424	LBP interface [polypeptide binding]; other site
438753013425	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
438753013426	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
438753013427	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
438753013428	alpha subunit interaction interface [polypeptide binding]; other site
438753013429	Walker A motif; other site
438753013430	ATP binding site [chemical binding]; other site
438753013431	Walker B motif; other site
438753013432	inhibitor binding site; inhibition site
438753013433	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
438753013434	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
438753013435	core domain interface [polypeptide binding]; other site
438753013436	delta subunit interface [polypeptide binding]; other site
438753013437	epsilon subunit interface [polypeptide binding]; other site
438753013438	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
438753013439	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
438753013440	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
438753013441	beta subunit interaction interface [polypeptide binding]; other site
438753013442	Walker A motif; other site
438753013443	ATP binding site [chemical binding]; other site
438753013444	Walker B motif; other site
438753013445	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
438753013446	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
438753013447	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
438753013448	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753013449	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753013450	Walker A/P-loop; other site
438753013451	ATP binding site [chemical binding]; other site
438753013452	Q-loop/lid; other site
438753013453	ABC transporter signature motif; other site
438753013454	Walker B; other site
438753013455	D-loop; other site
438753013456	H-loop/switch region; other site
438753013457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753013458	dimer interface [polypeptide binding]; other site
438753013459	conserved gate region; other site
438753013460	putative PBP binding loops; other site
438753013461	ABC-ATPase subunit interface; other site
438753013462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753013463	dimer interface [polypeptide binding]; other site
438753013464	conserved gate region; other site
438753013465	putative PBP binding loops; other site
438753013466	ABC-ATPase subunit interface; other site
438753013467	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753013468	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753013469	substrate binding pocket [chemical binding]; other site
438753013470	membrane-bound complex binding site; other site
438753013471	hinge residues; other site
438753013472	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
438753013473	C-terminal peptidase (prc); Region: prc; TIGR00225
438753013474	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
438753013475	protein binding site [polypeptide binding]; other site
438753013476	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
438753013477	Catalytic dyad [active]
438753013478	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
438753013479	Peptidase family M23; Region: Peptidase_M23; pfam01551
438753013480	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
438753013481	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
438753013482	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
438753013483	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
438753013484	active site
438753013485	(T/H)XGH motif; other site
438753013486	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
438753013487	putative catalytic cysteine [active]
438753013488	gamma-glutamyl kinase; Provisional; Region: PRK05429
438753013489	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
438753013490	nucleotide binding site [chemical binding]; other site
438753013491	homotetrameric interface [polypeptide binding]; other site
438753013492	putative phosphate binding site [ion binding]; other site
438753013493	putative allosteric binding site; other site
438753013494	PUA domain; Region: PUA; pfam01472
438753013495	transcriptional regulator NarP; Provisional; Region: PRK10403
438753013496	GTPase CgtA; Reviewed; Region: obgE; PRK12299
438753013497	GTP1/OBG; Region: GTP1_OBG; pfam01018
438753013498	Obg GTPase; Region: Obg; cd01898
438753013499	G1 box; other site
438753013500	GTP/Mg2+ binding site [chemical binding]; other site
438753013501	Switch I region; other site
438753013502	G2 box; other site
438753013503	G3 box; other site
438753013504	Switch II region; other site
438753013505	G4 box; other site
438753013506	G5 box; other site
438753013507	Protein of unknown function (DUF497); Region: DUF497; cl01108
438753013508	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
438753013509	primosome assembly protein PriA; Validated; Region: PRK05580
438753013510	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
438753013511	ATP binding site [chemical binding]; other site
438753013512	putative Mg++ binding site [ion binding]; other site
438753013513	Cytochrome c [Energy production and conversion]; Region: COG3258
438753013514	Cytochrome c; Region: Cytochrom_C; pfam00034
438753013515	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
438753013516	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
438753013517	5S rRNA interface [nucleotide binding]; other site
438753013518	CTC domain interface [polypeptide binding]; other site
438753013519	L16 interface [polypeptide binding]; other site
438753013520	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
438753013521	putative active site [active]
438753013522	catalytic residue [active]
438753013523	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
438753013524	putative active site [active]
438753013525	GTP-binding protein YchF; Reviewed; Region: PRK09601
438753013526	YchF GTPase; Region: YchF; cd01900
438753013527	G1 box; other site
438753013528	GTP/Mg2+ binding site [chemical binding]; other site
438753013529	Switch I region; other site
438753013530	G2 box; other site
438753013531	Switch II region; other site
438753013532	G3 box; other site
438753013533	G4 box; other site
438753013534	G5 box; other site
438753013535	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
438753013536	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
438753013537	putative active site [active]
438753013538	putative catalytic site [active]
438753013539	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
438753013540	putative active site [active]
438753013541	putative catalytic site [active]
438753013542	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
438753013543	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
438753013544	active site
438753013545	catalytic tetrad [active]
438753013546	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753013547	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753013548	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
438753013549	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
438753013550	active site
438753013551	multimer interface [polypeptide binding]; other site
438753013552	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
438753013553	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
438753013554	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
438753013555	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
438753013556	putative [4Fe-4S] binding site [ion binding]; other site
438753013557	putative molybdopterin cofactor binding site [chemical binding]; other site
438753013558	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
438753013559	putative molybdopterin cofactor binding site; other site
438753013560	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
438753013561	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
438753013562	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
438753013563	active site
438753013564	substrate binding site [chemical binding]; other site
438753013565	cosubstrate binding site; other site
438753013566	catalytic site [active]
438753013567	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
438753013568	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
438753013569	dimerization interface [polypeptide binding]; other site
438753013570	putative ATP binding site [chemical binding]; other site
438753013571	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753013572	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753013573	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
438753013574	dimerization interface [polypeptide binding]; other site
438753013575	glucosyltransferase MdoH; Provisional; Region: PRK05454
438753013576	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
438753013577	active site
438753013578	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
438753013579	putative NAD(P) binding site [chemical binding]; other site
438753013580	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
438753013581	active site
438753013582	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
438753013583	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753013584	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
438753013585	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
438753013586	RibD C-terminal domain; Region: RibD_C; cl17279
438753013587	GTP cyclohydrolase; Provisional; Region: PRK08815
438753013588	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
438753013589	dimerization interface [polypeptide binding]; other site
438753013590	active site
438753013591	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
438753013592	classical (c) SDRs; Region: SDR_c; cd05233
438753013593	NAD(P) binding site [chemical binding]; other site
438753013594	active site
438753013595	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753013596	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
438753013597	putative ADP-binding pocket [chemical binding]; other site
438753013598	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
438753013599	thiamine pyrophosphate protein; Validated; Region: PRK08199
438753013600	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
438753013601	PYR/PP interface [polypeptide binding]; other site
438753013602	dimer interface [polypeptide binding]; other site
438753013603	TPP binding site [chemical binding]; other site
438753013604	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
438753013605	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
438753013606	TPP-binding site [chemical binding]; other site
438753013607	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
438753013608	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
438753013609	tetrameric interface [polypeptide binding]; other site
438753013610	NAD binding site [chemical binding]; other site
438753013611	catalytic residues [active]
438753013612	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
438753013613	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753013614	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
438753013615	dimerization interface [polypeptide binding]; other site
438753013616	substrate binding pocket [chemical binding]; other site
438753013617	RNA polymerase sigma factor; Provisional; Region: PRK12547
438753013618	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753013619	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
438753013620	DNA binding residues [nucleotide binding]
438753013621	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
438753013622	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
438753013623	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
438753013624	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
438753013625	malate dehydrogenase; Provisional; Region: PRK05442
438753013626	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
438753013627	NAD(P) binding site [chemical binding]; other site
438753013628	dimer interface [polypeptide binding]; other site
438753013629	malate binding site [chemical binding]; other site
438753013630	amidase; Provisional; Region: PRK07056
438753013631	Amidase; Region: Amidase; cl11426
438753013632	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
438753013633	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
438753013634	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
438753013635	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
438753013636	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
438753013637	MarR family; Region: MarR_2; pfam12802
438753013638	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753013639	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
438753013640	glucose-1-dehydrogenase; Provisional; Region: PRK06947
438753013641	classical (c) SDRs; Region: SDR_c; cd05233
438753013642	NAD(P) binding site [chemical binding]; other site
438753013643	active site
438753013644	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
438753013645	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
438753013646	Peptidase family M23; Region: Peptidase_M23; pfam01551
438753013647	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
438753013648	Clp amino terminal domain; Region: Clp_N; pfam02861
438753013649	Clp amino terminal domain; Region: Clp_N; pfam02861
438753013650	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753013651	Walker A motif; other site
438753013652	ATP binding site [chemical binding]; other site
438753013653	Walker B motif; other site
438753013654	arginine finger; other site
438753013655	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753013656	Walker A motif; other site
438753013657	ATP binding site [chemical binding]; other site
438753013658	Walker B motif; other site
438753013659	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
438753013660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
438753013661	SnoaL-like domain; Region: SnoaL_2; pfam12680
438753013662	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753013663	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753013664	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
438753013665	active site
438753013666	hypothetical protein; Reviewed; Region: PRK00024
438753013667	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
438753013668	MPN+ (JAMM) motif; other site
438753013669	Zinc-binding site [ion binding]; other site
438753013670	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
438753013671	Protease inhibitor Inh; Region: Inh; pfam02974
438753013672	Protease inhibitor Inh; Region: Inh; pfam02974
438753013673	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
438753013674	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
438753013675	putative ligand binding site [chemical binding]; other site
438753013676	NAD binding site [chemical binding]; other site
438753013677	catalytic site [active]
438753013678	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
438753013679	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
438753013680	Walker A/P-loop; other site
438753013681	ATP binding site [chemical binding]; other site
438753013682	Q-loop/lid; other site
438753013683	ABC transporter signature motif; other site
438753013684	Walker B; other site
438753013685	D-loop; other site
438753013686	H-loop/switch region; other site
438753013687	TOBE domain; Region: TOBE_2; pfam08402
438753013688	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
438753013689	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
438753013690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753013691	dimer interface [polypeptide binding]; other site
438753013692	conserved gate region; other site
438753013693	putative PBP binding loops; other site
438753013694	ABC-ATPase subunit interface; other site
438753013695	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
438753013696	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753013697	dimer interface [polypeptide binding]; other site
438753013698	conserved gate region; other site
438753013699	putative PBP binding loops; other site
438753013700	ABC-ATPase subunit interface; other site
438753013701	hypothetical protein; Provisional; Region: PRK05208
438753013702	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
438753013703	anti sigma factor interaction site; other site
438753013704	regulatory phosphorylation site [posttranslational modification]; other site
438753013705	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
438753013706	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
438753013707	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
438753013708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
438753013709	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
438753013710	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
438753013711	active site
438753013712	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
438753013713	dimer interface [polypeptide binding]; other site
438753013714	substrate binding site [chemical binding]; other site
438753013715	catalytic residues [active]
438753013716	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
438753013717	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753013718	putative substrate translocation pore; other site
438753013719	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753013720	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753013721	dimerization interface [polypeptide binding]; other site
438753013722	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
438753013723	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
438753013724	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753013725	putative substrate translocation pore; other site
438753013726	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753013727	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
438753013728	FAD binding domain; Region: FAD_binding_4; pfam01565
438753013729	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
438753013730	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
438753013731	Nitrogen regulatory protein P-II; Region: P-II; smart00938
438753013732	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
438753013733	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
438753013734	active site
438753013735	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
438753013736	catalytic triad [active]
438753013737	dimer interface [polypeptide binding]; other site
438753013738	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
438753013739	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
438753013740	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
438753013741	HicB family; Region: HicB; pfam05534
438753013742	Uncharacterized conserved protein [Function unknown]; Region: COG2835
438753013743	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
438753013744	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
438753013745	dimer interface [polypeptide binding]; other site
438753013746	motif 1; other site
438753013747	active site
438753013748	motif 2; other site
438753013749	motif 3; other site
438753013750	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
438753013751	anticodon binding site; other site
438753013752	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
438753013753	MOSC domain; Region: MOSC; pfam03473
438753013754	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
438753013755	CoenzymeA binding site [chemical binding]; other site
438753013756	subunit interaction site [polypeptide binding]; other site
438753013757	PHB binding site; other site
438753013758	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
438753013759	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
438753013760	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
438753013761	active site
438753013762	HIGH motif; other site
438753013763	nucleotide binding site [chemical binding]; other site
438753013764	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
438753013765	active site
438753013766	KMSKS motif; other site
438753013767	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
438753013768	tRNA binding surface [nucleotide binding]; other site
438753013769	anticodon binding site; other site
438753013770	lipoprotein signal peptidase; Provisional; Region: PRK14796
438753013771	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
438753013772	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
438753013773	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
438753013774	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
438753013775	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
438753013776	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
438753013777	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
438753013778	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
438753013779	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
438753013780	lipoyl attachment site [posttranslational modification]; other site
438753013781	OsmC-like protein; Region: OsmC; cl00767
438753013782	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
438753013783	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
438753013784	tetramer interface [polypeptide binding]; other site
438753013785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753013786	catalytic residue [active]
438753013787	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
438753013788	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
438753013789	catalytic residue [active]
438753013790	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
438753013791	EamA-like transporter family; Region: EamA; pfam00892
438753013792	L-lactate permease; Region: Lactate_perm; cl00701
438753013793	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
438753013794	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
438753013795	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
438753013796	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
438753013797	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753013798	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
438753013799	DNA binding residues [nucleotide binding]
438753013800	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
438753013801	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
438753013802	RNA binding surface [nucleotide binding]; other site
438753013803	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
438753013804	active site
438753013805	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
438753013806	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
438753013807	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
438753013808	catalytic residues [active]
438753013809	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
438753013810	AAA domain; Region: AAA_23; pfam13476
438753013811	Walker A/P-loop; other site
438753013812	ATP binding site [chemical binding]; other site
438753013813	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
438753013814	ABC transporter signature motif; other site
438753013815	Walker B; other site
438753013816	D-loop; other site
438753013817	H-loop/switch region; other site
438753013818	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
438753013819	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
438753013820	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
438753013821	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
438753013822	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
438753013823	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
438753013824	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
438753013825	F0F1 ATP synthase subunit B; Provisional; Region: PRK14475
438753013826	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
438753013827	active site
438753013828	catalytic triad [active]
438753013829	oxyanion hole [active]
438753013830	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
438753013831	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
438753013832	putative dimer interface [polypeptide binding]; other site
438753013833	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
438753013834	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
438753013835	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
438753013836	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
438753013837	active site
438753013838	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
438753013839	Response regulator receiver domain; Region: Response_reg; pfam00072
438753013840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753013841	active site
438753013842	phosphorylation site [posttranslational modification]
438753013843	intermolecular recognition site; other site
438753013844	dimerization interface [polypeptide binding]; other site
438753013845	ferrochelatase; Reviewed; Region: hemH; PRK00035
438753013846	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
438753013847	C-terminal domain interface [polypeptide binding]; other site
438753013848	active site
438753013849	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
438753013850	active site
438753013851	N-terminal domain interface [polypeptide binding]; other site
438753013852	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
438753013853	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
438753013854	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
438753013855	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753013856	putative active site [active]
438753013857	heme pocket [chemical binding]; other site
438753013858	LytTr DNA-binding domain; Region: LytTR; smart00850
438753013859	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
438753013860	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
438753013861	active site
438753013862	metal binding site [ion binding]; metal-binding site
438753013863	hexamer interface [polypeptide binding]; other site
438753013864	beta-lactamase TEM; Provisional; Region: PRK15442
438753013865	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
438753013866	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
438753013867	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753013868	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753013869	dimerization interface [polypeptide binding]; other site
438753013870	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
438753013871	catalytic triad [active]
438753013872	metal binding site [ion binding]; metal-binding site
438753013873	conserved cis-peptide bond; other site
438753013874	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
438753013875	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
438753013876	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
438753013877	dimer interface [polypeptide binding]; other site
438753013878	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
438753013879	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
438753013880	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
438753013881	ribonuclease PH; Reviewed; Region: rph; PRK00173
438753013882	Ribonuclease PH; Region: RNase_PH_bact; cd11362
438753013883	hexamer interface [polypeptide binding]; other site
438753013884	active site
438753013885	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
438753013886	active site
438753013887	dimerization interface [polypeptide binding]; other site
438753013888	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
438753013889	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753013890	FeS/SAM binding site; other site
438753013891	HemN C-terminal domain; Region: HemN_C; pfam06969
438753013892	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
438753013893	putative homodimer interface [polypeptide binding]; other site
438753013894	putative homotetramer interface [polypeptide binding]; other site
438753013895	putative allosteric switch controlling residues; other site
438753013896	putative metal binding site [ion binding]; other site
438753013897	putative homodimer-homodimer interface [polypeptide binding]; other site
438753013898	Uncharacterized conserved protein [Function unknown]; Region: COG3350
438753013899	Uncharacterized conserved protein [Function unknown]; Region: COG3350
438753013900	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
438753013901	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
438753013902	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
438753013903	active site
438753013904	motif I; other site
438753013905	motif II; other site
438753013906	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
438753013907	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
438753013908	active site
438753013909	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
438753013910	GSH binding site [chemical binding]; other site
438753013911	catalytic residues [active]
438753013912	nitrilase; Region: PLN02798
438753013913	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
438753013914	putative active site [active]
438753013915	catalytic triad [active]
438753013916	dimer interface [polypeptide binding]; other site
438753013917	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
438753013918	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
438753013919	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
438753013920	substrate binding pocket [chemical binding]; other site
438753013921	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
438753013922	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
438753013923	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753013924	S-adenosylmethionine binding site [chemical binding]; other site
438753013925	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
438753013926	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
438753013927	active site
438753013928	HIGH motif; other site
438753013929	dimer interface [polypeptide binding]; other site
438753013930	KMSKS motif; other site
438753013931	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
438753013932	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
438753013933	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
438753013934	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
438753013935	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
438753013936	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
438753013937	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
438753013938	RES domain; Region: RES; smart00953
438753013939	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
438753013940	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
438753013941	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
438753013942	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
438753013943	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753013944	NAD(P) binding site [chemical binding]; other site
438753013945	active site
438753013946	acyl carrier protein; Provisional; Region: acpP; PRK00982
438753013947	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
438753013948	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
438753013949	dimer interface [polypeptide binding]; other site
438753013950	active site
438753013951	YceG-like family; Region: YceG; pfam02618
438753013952	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
438753013953	dimerization interface [polypeptide binding]; other site
438753013954	hypothetical protein; Provisional; Region: PRK11820
438753013955	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
438753013956	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
438753013957	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
438753013958	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
438753013959	catalytic site [active]
438753013960	G-X2-G-X-G-K; other site
438753013961	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
438753013962	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
438753013963	catalytic core [active]
438753013964	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
438753013965	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
438753013966	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
438753013967	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
438753013968	SurA N-terminal domain; Region: SurA_N; pfam09312
438753013969	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
438753013970	OstA-like protein; Region: OstA; cl00844
438753013971	OstA-like protein; Region: OstA; cl00844
438753013972	Organic solvent tolerance protein; Region: OstA_C; pfam04453
438753013973	Predicted permeases [General function prediction only]; Region: COG0795
438753013974	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
438753013975	Predicted permeases [General function prediction only]; Region: COG0795
438753013976	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
438753013977	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
438753013978	hypothetical protein; Provisional; Region: PRK06132
438753013979	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
438753013980	GTP-binding protein Der; Reviewed; Region: PRK00093
438753013981	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
438753013982	G1 box; other site
438753013983	GTP/Mg2+ binding site [chemical binding]; other site
438753013984	Switch I region; other site
438753013985	G2 box; other site
438753013986	Switch II region; other site
438753013987	G3 box; other site
438753013988	G4 box; other site
438753013989	G5 box; other site
438753013990	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
438753013991	G1 box; other site
438753013992	GTP/Mg2+ binding site [chemical binding]; other site
438753013993	Switch I region; other site
438753013994	G2 box; other site
438753013995	G3 box; other site
438753013996	Switch II region; other site
438753013997	G4 box; other site
438753013998	G5 box; other site
438753013999	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
438753014000	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
438753014001	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
438753014002	active site
438753014003	metal binding site [ion binding]; metal-binding site
438753014004	oligomerization interface [polypeptide binding]; other site
438753014005	NnrU protein; Region: NnrU; pfam07298
438753014006	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
438753014007	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
438753014008	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
438753014009	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
438753014010	active site
438753014011	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
438753014012	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
438753014013	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
438753014014	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753014015	Coenzyme A binding pocket [chemical binding]; other site
438753014016	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
438753014017	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
438753014018	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
438753014019	dimerization interface [polypeptide binding]; other site
438753014020	putative DNA binding site [nucleotide binding]; other site
438753014021	putative Zn2+ binding site [ion binding]; other site
438753014022	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753014023	S-adenosylmethionine binding site [chemical binding]; other site
438753014024	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
438753014025	FAD binding site [chemical binding]; other site
438753014026	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
438753014027	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
438753014028	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
438753014029	substrate binding pocket [chemical binding]; other site
438753014030	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
438753014031	B12 binding site [chemical binding]; other site
438753014032	cobalt ligand [ion binding]; other site
438753014033	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
438753014034	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
438753014035	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
438753014036	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
438753014037	Walker A motif; other site
438753014038	ATP binding site [chemical binding]; other site
438753014039	Walker B motif; other site
438753014040	arginine finger; other site
438753014041	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
438753014042	Phosphopantetheine attachment site; Region: PP-binding; cl09936
438753014043	Helix-turn-helix domain; Region: HTH_31; pfam13560
438753014044	sequence-specific DNA binding site [nucleotide binding]; other site
438753014045	salt bridge; other site
438753014046	Methyltransferase domain; Region: Methyltransf_23; pfam13489
438753014047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753014048	S-adenosylmethionine binding site [chemical binding]; other site
438753014049	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
438753014050	glutathione synthetase; Provisional; Region: PRK05246
438753014051	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
438753014052	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
438753014053	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753014054	S-adenosylmethionine binding site [chemical binding]; other site
438753014055	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
438753014056	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
438753014057	Ligand Binding Site [chemical binding]; other site
438753014058	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
438753014059	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
438753014060	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
438753014061	heat shock protein 90; Provisional; Region: PRK05218
438753014062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753014063	ATP binding site [chemical binding]; other site
438753014064	Mg2+ binding site [ion binding]; other site
438753014065	G-X-G motif; other site
438753014066	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
438753014067	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
438753014068	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
438753014069	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
438753014070	hydrogenase 4 subunit F; Validated; Region: PRK06458
438753014071	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
438753014072	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
438753014073	NADH dehydrogenase; Region: NADHdh; cl00469
438753014074	hydrogenase 4 subunit B; Validated; Region: PRK06521
438753014075	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
438753014076	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
438753014077	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753014078	Coenzyme A binding pocket [chemical binding]; other site
438753014079	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
438753014080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753014081	active site
438753014082	phosphorylation site [posttranslational modification]
438753014083	intermolecular recognition site; other site
438753014084	dimerization interface [polypeptide binding]; other site
438753014085	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
438753014086	DNA binding site [nucleotide binding]
438753014087	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753014088	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753014089	dimer interface [polypeptide binding]; other site
438753014090	phosphorylation site [posttranslational modification]
438753014091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753014092	ATP binding site [chemical binding]; other site
438753014093	Mg2+ binding site [ion binding]; other site
438753014094	G-X-G motif; other site
438753014095	Response regulator receiver domain; Region: Response_reg; pfam00072
438753014096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753014097	active site
438753014098	phosphorylation site [posttranslational modification]
438753014099	intermolecular recognition site; other site
438753014100	dimerization interface [polypeptide binding]; other site
438753014101	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
438753014102	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
438753014103	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
438753014104	classical (c) SDRs; Region: SDR_c; cd05233
438753014105	NAD(P) binding site [chemical binding]; other site
438753014106	active site
438753014107	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
438753014108	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753014109	NAD(P) binding site [chemical binding]; other site
438753014110	active site
438753014111	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
438753014112	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753014113	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753014114	Walker A/P-loop; other site
438753014115	ATP binding site [chemical binding]; other site
438753014116	Q-loop/lid; other site
438753014117	ABC transporter signature motif; other site
438753014118	Walker B; other site
438753014119	D-loop; other site
438753014120	H-loop/switch region; other site
438753014121	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753014122	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753014123	dimer interface [polypeptide binding]; other site
438753014124	conserved gate region; other site
438753014125	putative PBP binding loops; other site
438753014126	ABC-ATPase subunit interface; other site
438753014127	NMT1-like family; Region: NMT1_2; pfam13379
438753014128	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
438753014129	Transcriptional regulators [Transcription]; Region: GntR; COG1802
438753014130	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753014131	DNA-binding site [nucleotide binding]; DNA binding site
438753014132	FCD domain; Region: FCD; pfam07729
438753014133	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753014134	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
438753014135	active site
438753014136	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
438753014137	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
438753014138	active site
438753014139	catalytic tetrad [active]
438753014140	short chain dehydrogenase; Provisional; Region: PRK08339
438753014141	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
438753014142	putative NAD(P) binding site [chemical binding]; other site
438753014143	putative active site [active]
438753014144	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
438753014145	active site
438753014146	homotetramer interface [polypeptide binding]; other site
438753014147	homodimer interface [polypeptide binding]; other site
438753014148	Cytochrome c; Region: Cytochrom_C; cl11414
438753014149	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
438753014150	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
438753014151	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
438753014152	N-terminal plug; other site
438753014153	ligand-binding site [chemical binding]; other site
438753014154	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
438753014155	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
438753014156	putative hemin binding site; other site
438753014157	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
438753014158	dimer interface [polypeptide binding]; other site
438753014159	putative PBP binding regions; other site
438753014160	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
438753014161	ABC-ATPase subunit  interface; other site
438753014162	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
438753014163	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
438753014164	Walker A/P-loop; other site
438753014165	ATP binding site [chemical binding]; other site
438753014166	Q-loop/lid; other site
438753014167	ABC transporter signature motif; other site
438753014168	Walker B; other site
438753014169	D-loop; other site
438753014170	H-loop/switch region; other site
438753014171	L-aspartate dehydrogenase; Provisional; Region: PRK13303
438753014172	Domain of unknown function DUF108; Region: DUF108; pfam01958
438753014173	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753014174	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753014175	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753014176	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753014177	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
438753014178	Walker A/P-loop; other site
438753014179	ATP binding site [chemical binding]; other site
438753014180	Q-loop/lid; other site
438753014181	ABC transporter signature motif; other site
438753014182	Walker B; other site
438753014183	D-loop; other site
438753014184	H-loop/switch region; other site
438753014185	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
438753014186	Walker A/P-loop; other site
438753014187	ATP binding site [chemical binding]; other site
438753014188	Q-loop/lid; other site
438753014189	ABC transporter signature motif; other site
438753014190	Walker B; other site
438753014191	D-loop; other site
438753014192	H-loop/switch region; other site
438753014193	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
438753014194	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
438753014195	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
438753014196	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
438753014197	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
438753014198	putative chaperone; Provisional; Region: PRK11678
438753014199	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
438753014200	nucleotide binding site [chemical binding]; other site
438753014201	putative NEF/HSP70 interaction site [polypeptide binding]; other site
438753014202	SBD interface [polypeptide binding]; other site
438753014203	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
438753014204	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
438753014205	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
438753014206	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
438753014207	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753014208	dimer interface [polypeptide binding]; other site
438753014209	conserved gate region; other site
438753014210	putative PBP binding loops; other site
438753014211	ABC-ATPase subunit interface; other site
438753014212	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
438753014213	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
438753014214	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
438753014215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753014216	dimer interface [polypeptide binding]; other site
438753014217	conserved gate region; other site
438753014218	ABC-ATPase subunit interface; other site
438753014219	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
438753014220	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
438753014221	Walker A/P-loop; other site
438753014222	ATP binding site [chemical binding]; other site
438753014223	Q-loop/lid; other site
438753014224	ABC transporter signature motif; other site
438753014225	Walker B; other site
438753014226	D-loop; other site
438753014227	H-loop/switch region; other site
438753014228	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
438753014229	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
438753014230	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
438753014231	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
438753014232	urea carboxylase; Region: urea_carbox; TIGR02712
438753014233	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
438753014234	ATP-grasp domain; Region: ATP-grasp_4; cl17255
438753014235	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
438753014236	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
438753014237	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
438753014238	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
438753014239	carboxyltransferase (CT) interaction site; other site
438753014240	biotinylation site [posttranslational modification]; other site
438753014241	allophanate hydrolase; Region: allophanate_hyd; TIGR02713
438753014242	Transcriptional regulators [Transcription]; Region: PurR; COG1609
438753014243	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
438753014244	DNA binding site [nucleotide binding]
438753014245	domain linker motif; other site
438753014246	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
438753014247	putative dimerization interface [polypeptide binding]; other site
438753014248	putative ligand binding site [chemical binding]; other site
438753014249	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
438753014250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753014251	dimer interface [polypeptide binding]; other site
438753014252	conserved gate region; other site
438753014253	putative PBP binding loops; other site
438753014254	ABC-ATPase subunit interface; other site
438753014255	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
438753014256	dimer interface [polypeptide binding]; other site
438753014257	conserved gate region; other site
438753014258	putative PBP binding loops; other site
438753014259	ABC-ATPase subunit interface; other site
438753014260	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
438753014261	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
438753014262	substrate binding pocket [chemical binding]; other site
438753014263	membrane-bound complex binding site; other site
438753014264	hinge residues; other site
438753014265	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
438753014266	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
438753014267	Walker A/P-loop; other site
438753014268	ATP binding site [chemical binding]; other site
438753014269	Q-loop/lid; other site
438753014270	ABC transporter signature motif; other site
438753014271	Walker B; other site
438753014272	D-loop; other site
438753014273	H-loop/switch region; other site
438753014274	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
438753014275	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
438753014276	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
438753014277	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
438753014278	active site
438753014279	intersubunit interface [polypeptide binding]; other site
438753014280	catalytic residue [active]
438753014281	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753014282	Major Facilitator Superfamily; Region: MFS_1; pfam07690
438753014283	putative substrate translocation pore; other site
438753014284	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
438753014285	YcxB-like protein; Region: YcxB; pfam14317
438753014286	YcxB-like protein; Region: YcxB; pfam14317
438753014287	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
438753014288	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
438753014289	Bacterial sugar transferase; Region: Bac_transf; pfam02397
438753014290	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
438753014291	leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011
438753014292	Winged helix-turn helix; Region: HTH_29; pfam13551
438753014293	Integrase core domain; Region: rve; pfam00665
438753014294	Integrase core domain; Region: rve_3; pfam13683
438753014295	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
438753014296	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
438753014297	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
438753014298	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
438753014299	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
438753014300	SLBB domain; Region: SLBB; pfam10531
438753014301	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
438753014302	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
438753014303	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
438753014304	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
438753014305	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
438753014306	active site
438753014307	hypothetical protein; Validated; Region: PRK07080
438753014308	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
438753014309	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
438753014310	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
438753014311	active site
438753014312	Autotransporter beta-domain; Region: Autotransporter; pfam03797
438753014313	amidase; Provisional; Region: PRK07486
438753014314	Amidase; Region: Amidase; cl11426
438753014315	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
438753014316	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
438753014317	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
438753014318	DNA binding residues [nucleotide binding]
438753014319	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
438753014320	FecR protein; Region: FecR; pfam04773
438753014321	Secretin and TonB N terminus short domain; Region: STN; smart00965
438753014322	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
438753014323	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
438753014324	N-terminal plug; other site
438753014325	ligand-binding site [chemical binding]; other site
438753014326	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
438753014327	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
438753014328	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753014329	Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359
438753014330	putative ligand binding site [chemical binding]; other site
438753014331	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
438753014332	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753014333	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753014334	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
438753014335	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753014336	putative substrate translocation pore; other site
438753014337	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
438753014338	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753014339	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753014340	metal binding site [ion binding]; metal-binding site
438753014341	active site
438753014342	I-site; other site
438753014343	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
438753014344	dimerization interface [polypeptide binding]; other site
438753014345	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753014346	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753014347	dimer interface [polypeptide binding]; other site
438753014348	putative CheW interface [polypeptide binding]; other site
438753014349	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
438753014350	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
438753014351	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
438753014352	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
438753014353	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
438753014354	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
438753014355	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
438753014356	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
438753014357	BA14K-like protein; Region: BA14K; pfam07886
438753014358	BA14K-like protein; Region: BA14K; pfam07886
438753014359	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
438753014360	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
438753014361	23S rRNA binding site [nucleotide binding]; other site
438753014362	L21 binding site [polypeptide binding]; other site
438753014363	L13 binding site [polypeptide binding]; other site
438753014364	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
438753014365	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
438753014366	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
438753014367	dimer interface [polypeptide binding]; other site
438753014368	motif 1; other site
438753014369	active site
438753014370	motif 2; other site
438753014371	motif 3; other site
438753014372	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
438753014373	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
438753014374	putative tRNA-binding site [nucleotide binding]; other site
438753014375	B3/4 domain; Region: B3_4; pfam03483
438753014376	tRNA synthetase B5 domain; Region: B5; smart00874
438753014377	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
438753014378	dimer interface [polypeptide binding]; other site
438753014379	motif 1; other site
438753014380	motif 3; other site
438753014381	motif 2; other site
438753014382	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
438753014383	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
438753014384	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
438753014385	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
438753014386	substrate binding pocket [chemical binding]; other site
438753014387	chain length determination region; other site
438753014388	substrate-Mg2+ binding site; other site
438753014389	catalytic residues [active]
438753014390	aspartate-rich region 1; other site
438753014391	active site lid residues [active]
438753014392	aspartate-rich region 2; other site
438753014393	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
438753014394	Transglycosylase; Region: Transgly; cl17702
438753014395	intracellular septation protein A; Reviewed; Region: PRK00259
438753014396	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
438753014397	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
438753014398	catalytic residues [active]
438753014399	central insert; other site
438753014400	heme exporter protein CcmC; Region: ccmC; TIGR01191
438753014401	CcmB protein; Region: CcmB; cl17444
438753014402	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
438753014403	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
438753014404	Walker A/P-loop; other site
438753014405	ATP binding site [chemical binding]; other site
438753014406	Q-loop/lid; other site
438753014407	ABC transporter signature motif; other site
438753014408	Walker B; other site
438753014409	D-loop; other site
438753014410	H-loop/switch region; other site
438753014411	aconitate hydratase; Validated; Region: PRK09277
438753014412	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
438753014413	substrate binding site [chemical binding]; other site
438753014414	ligand binding site [chemical binding]; other site
438753014415	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
438753014416	substrate binding site [chemical binding]; other site
438753014417	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
438753014418	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
438753014419	DNA polymerase I; Region: pola; TIGR00593
438753014420	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
438753014421	active site
438753014422	metal binding site 1 [ion binding]; metal-binding site
438753014423	putative 5' ssDNA interaction site; other site
438753014424	metal binding site 3; metal-binding site
438753014425	metal binding site 2 [ion binding]; metal-binding site
438753014426	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
438753014427	putative DNA binding site [nucleotide binding]; other site
438753014428	putative metal binding site [ion binding]; other site
438753014429	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
438753014430	active site
438753014431	catalytic site [active]
438753014432	substrate binding site [chemical binding]; other site
438753014433	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
438753014434	active site
438753014435	DNA binding site [nucleotide binding]
438753014436	catalytic site [active]
438753014437	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753014438	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753014439	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
438753014440	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
438753014441	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
438753014442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
438753014443	DNA-binding site [nucleotide binding]; DNA binding site
438753014444	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753014445	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753014446	homodimer interface [polypeptide binding]; other site
438753014447	catalytic residue [active]
438753014448	DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014
438753014449	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
438753014450	DNA binding site [nucleotide binding]
438753014451	domain linker motif; other site
438753014452	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
438753014453	putative dimerization interface [polypeptide binding]; other site
438753014454	putative ligand binding site [chemical binding]; other site
438753014455	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
438753014456	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
438753014457	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
438753014458	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
438753014459	Predicted methyltransferases [General function prediction only]; Region: COG0313
438753014460	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
438753014461	putative SAM binding site [chemical binding]; other site
438753014462	putative homodimer interface [polypeptide binding]; other site
438753014463	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
438753014464	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753014465	putative ligand binding site [chemical binding]; other site
438753014466	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
438753014467	Part of AAA domain; Region: AAA_19; pfam13245
438753014468	Family description; Region: UvrD_C_2; pfam13538
438753014469	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753014470	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753014471	metal binding site [ion binding]; metal-binding site
438753014472	active site
438753014473	I-site; other site
438753014474	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
438753014475	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753014476	S-adenosylmethionine binding site [chemical binding]; other site
438753014477	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
438753014478	active site
438753014479	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
438753014480	FAD binding domain; Region: FAD_binding_4; pfam01565
438753014481	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
438753014482	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
438753014483	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
438753014484	folate binding site [chemical binding]; other site
438753014485	NADP+ binding site [chemical binding]; other site
438753014486	probable polyamine oxidase; Region: PLN02268
438753014487	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
438753014488	tmRNA-coding RNA
438753014489	tmRNA-acceptor RNA
438753014490	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
438753014491	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
438753014492	active site
438753014493	DNA binding site [nucleotide binding]
438753014494	Int/Topo IB signature motif; other site
438753014495	shikimate kinase; Provisional; Region: PRK13946
438753014496	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
438753014497	ADP binding site [chemical binding]; other site
438753014498	magnesium binding site [ion binding]; other site
438753014499	putative shikimate binding site; other site
438753014500	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
438753014501	active site
438753014502	dimer interface [polypeptide binding]; other site
438753014503	metal binding site [ion binding]; metal-binding site
438753014504	aspartate kinase; Reviewed; Region: PRK06635
438753014505	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
438753014506	putative nucleotide binding site [chemical binding]; other site
438753014507	putative catalytic residues [active]
438753014508	putative Mg ion binding site [ion binding]; other site
438753014509	putative aspartate binding site [chemical binding]; other site
438753014510	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
438753014511	putative allosteric regulatory site; other site
438753014512	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
438753014513	putative allosteric regulatory residue; other site
438753014514	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
438753014515	GAF domain; Region: GAF; pfam01590
438753014516	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
438753014517	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
438753014518	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
438753014519	peptide chain release factor 1; Validated; Region: prfA; PRK00591
438753014520	This domain is found in peptide chain release factors; Region: PCRF; smart00937
438753014521	RF-1 domain; Region: RF-1; pfam00472
438753014522	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
438753014523	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753014524	S-adenosylmethionine binding site [chemical binding]; other site
438753014525	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
438753014526	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
438753014527	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
438753014528	dimer interface [polypeptide binding]; other site
438753014529	putative CheW interface [polypeptide binding]; other site
438753014530	pantothenate kinase; Provisional; Region: PRK05439
438753014531	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
438753014532	ATP-binding site [chemical binding]; other site
438753014533	CoA-binding site [chemical binding]; other site
438753014534	Mg2+-binding site [ion binding]; other site
438753014535	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
438753014536	metal binding site [ion binding]; metal-binding site
438753014537	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
438753014538	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
438753014539	substrate binding site [chemical binding]; other site
438753014540	glutamase interaction surface [polypeptide binding]; other site
438753014541	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
438753014542	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
438753014543	catalytic residues [active]
438753014544	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
438753014545	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
438753014546	putative active site [active]
438753014547	oxyanion strand; other site
438753014548	catalytic triad [active]
438753014549	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
438753014550	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
438753014551	putative active site pocket [active]
438753014552	4-fold oligomerization interface [polypeptide binding]; other site
438753014553	metal binding residues [ion binding]; metal-binding site
438753014554	3-fold/trimer interface [polypeptide binding]; other site
438753014555	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
438753014556	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
438753014557	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
438753014558	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
438753014559	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
438753014560	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
438753014561	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
438753014562	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753014563	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753014564	Walker A/P-loop; other site
438753014565	ATP binding site [chemical binding]; other site
438753014566	Q-loop/lid; other site
438753014567	ABC transporter signature motif; other site
438753014568	Walker B; other site
438753014569	D-loop; other site
438753014570	H-loop/switch region; other site
438753014571	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753014572	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753014573	Walker A/P-loop; other site
438753014574	ATP binding site [chemical binding]; other site
438753014575	Q-loop/lid; other site
438753014576	ABC transporter signature motif; other site
438753014577	Walker B; other site
438753014578	D-loop; other site
438753014579	H-loop/switch region; other site
438753014580	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753014581	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
438753014582	putative ligand binding site [chemical binding]; other site
438753014583	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753014584	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753014585	TM-ABC transporter signature motif; other site
438753014586	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753014587	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753014588	TM-ABC transporter signature motif; other site
438753014589	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
438753014590	Peptidase family M23; Region: Peptidase_M23; pfam01551
438753014591	Pirin-related protein [General function prediction only]; Region: COG1741
438753014592	Pirin; Region: Pirin; pfam02678
438753014593	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
438753014594	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753014595	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753014596	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
438753014597	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753014598	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
438753014599	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
438753014600	Walker A/P-loop; other site
438753014601	ATP binding site [chemical binding]; other site
438753014602	Q-loop/lid; other site
438753014603	ABC transporter signature motif; other site
438753014604	Walker B; other site
438753014605	D-loop; other site
438753014606	H-loop/switch region; other site
438753014607	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
438753014608	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
438753014609	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
438753014610	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
438753014611	Low-spin heme binding site [chemical binding]; other site
438753014612	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
438753014613	Putative water exit pathway; other site
438753014614	Binuclear center (active site) [active]
438753014615	Putative proton exit pathway; other site
438753014616	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
438753014617	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
438753014618	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
438753014619	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
438753014620	Cytochrome c; Region: Cytochrom_C; pfam00034
438753014621	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
438753014622	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
438753014623	4Fe-4S binding domain; Region: Fer4_5; pfam12801
438753014624	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
438753014625	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
438753014626	FixH; Region: FixH; pfam05751
438753014627	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
438753014628	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
438753014629	metal-binding site [ion binding]
438753014630	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
438753014631	Soluble P-type ATPase [General function prediction only]; Region: COG4087
438753014632	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
438753014633	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
438753014634	DctM-like transporters; Region: DctM; pfam06808
438753014635	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
438753014636	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
438753014637	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
438753014638	Transcriptional regulator [Transcription]; Region: IclR; COG1414
438753014639	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
438753014640	Bacterial transcriptional regulator; Region: IclR; pfam01614
438753014641	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
438753014642	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
438753014643	active site
438753014644	acyl-CoA synthetase; Validated; Region: PRK07470
438753014645	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
438753014646	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
438753014647	acyl-activating enzyme (AAE) consensus motif; other site
438753014648	acyl-activating enzyme (AAE) consensus motif; other site
438753014649	putative AMP binding site [chemical binding]; other site
438753014650	putative active site [active]
438753014651	putative CoA binding site [chemical binding]; other site
438753014652	trimer interface [polypeptide binding]; other site
438753014653	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720
438753014654	putative Zn binding site [ion binding]; other site
438753014655	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
438753014656	trimer interface [polypeptide binding]; other site
438753014657	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
438753014658	classical (c) SDRs; Region: SDR_c; cd05233
438753014659	NAD(P) binding site [chemical binding]; other site
438753014660	active site
438753014661	PAS domain S-box; Region: sensory_box; TIGR00229
438753014662	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753014663	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753014664	metal binding site [ion binding]; metal-binding site
438753014665	active site
438753014666	I-site; other site
438753014667	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753014668	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
438753014669	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
438753014670	Mg++ binding site [ion binding]; other site
438753014671	putative catalytic motif [active]
438753014672	putative substrate binding site [chemical binding]; other site
438753014673	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
438753014674	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
438753014675	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
438753014676	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
438753014677	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
438753014678	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
438753014679	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
438753014680	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
438753014681	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
438753014682	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
438753014683	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
438753014684	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
438753014685	MraW methylase family; Region: Methyltransf_5; cl17771
438753014686	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
438753014687	cell division protein MraZ; Reviewed; Region: PRK00326
438753014688	MraZ protein; Region: MraZ; pfam02381
438753014689	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
438753014690	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
438753014691	putative metal binding site [ion binding]; other site
438753014692	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
438753014693	HSP70 interaction site [polypeptide binding]; other site
438753014694	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
438753014695	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
438753014696	amidase catalytic site [active]
438753014697	Zn binding residues [ion binding]; other site
438753014698	substrate binding site [chemical binding]; other site
438753014699	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
438753014700	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
438753014701	ArsC family; Region: ArsC; pfam03960
438753014702	catalytic residues [active]
438753014703	Uncharacterized conserved protein [Function unknown]; Region: COG5276
438753014704	LVIVD repeat; Region: LVIVD; pfam08309
438753014705	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
438753014706	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
438753014707	cell division protein FtsW; Region: ftsW; TIGR02614
438753014708	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
438753014709	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
438753014710	active site
438753014711	homodimer interface [polypeptide binding]; other site
438753014712	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
438753014713	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
438753014714	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
438753014715	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
438753014716	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
438753014717	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
438753014718	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
438753014719	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
438753014720	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
438753014721	FAD binding domain; Region: FAD_binding_4; pfam01565
438753014722	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
438753014723	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
438753014724	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
438753014725	ATP-grasp domain; Region: ATP-grasp_4; cl17255
438753014726	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
438753014727	Cell division protein FtsQ; Region: FtsQ; pfam03799
438753014728	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
438753014729	Cell division protein FtsA; Region: FtsA; smart00842
438753014730	Cell division protein FtsA; Region: FtsA; pfam14450
438753014731	cell division protein FtsZ; Validated; Region: PRK09330
438753014732	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
438753014733	nucleotide binding site [chemical binding]; other site
438753014734	SulA interaction site; other site
438753014735	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
438753014736	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
438753014737	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
438753014738	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
438753014739	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
438753014740	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
438753014741	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
438753014742	Walker A/P-loop; other site
438753014743	ATP binding site [chemical binding]; other site
438753014744	Q-loop/lid; other site
438753014745	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
438753014746	ABC transporter signature motif; other site
438753014747	Walker B; other site
438753014748	D-loop; other site
438753014749	H-loop/switch region; other site
438753014750	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753014751	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753014752	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
438753014753	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753014754	NAD(P) binding site [chemical binding]; other site
438753014755	active site
438753014756	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
438753014757	putative NAD(P) binding site [chemical binding]; other site
438753014758	putative active site [active]
438753014759	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
438753014760	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
438753014761	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
438753014762	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
438753014763	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
438753014764	hypothetical protein; Provisional; Region: PRK09256
438753014765	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
438753014766	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
438753014767	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
438753014768	active site
438753014769	nucleophile elbow; other site
438753014770	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753014771	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
438753014772	NAD(P) binding site [chemical binding]; other site
438753014773	active site
438753014774	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
438753014775	metal binding site 2 [ion binding]; metal-binding site
438753014776	putative DNA binding helix; other site
438753014777	metal binding site 1 [ion binding]; metal-binding site
438753014778	dimer interface [polypeptide binding]; other site
438753014779	structural Zn2+ binding site [ion binding]; other site
438753014780	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753014781	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
438753014782	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
438753014783	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
438753014784	Uncharacterized conserved protein [Function unknown]; Region: COG2353
438753014785	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
438753014786	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
438753014787	acyl-activating enzyme (AAE) consensus motif; other site
438753014788	active site
438753014789	AMP binding site [chemical binding]; other site
438753014790	CoA binding site [chemical binding]; other site
438753014791	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
438753014792	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
438753014793	Walker A/P-loop; other site
438753014794	ATP binding site [chemical binding]; other site
438753014795	Q-loop/lid; other site
438753014796	ABC transporter signature motif; other site
438753014797	Walker B; other site
438753014798	D-loop; other site
438753014799	H-loop/switch region; other site
438753014800	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
438753014801	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
438753014802	putative ligand binding site [chemical binding]; other site
438753014803	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
438753014804	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
438753014805	TM-ABC transporter signature motif; other site
438753014806	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
438753014807	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
438753014808	TM-ABC transporter signature motif; other site
438753014809	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
438753014810	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
438753014811	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
438753014812	acyl-activating enzyme (AAE) consensus motif; other site
438753014813	putative AMP binding site [chemical binding]; other site
438753014814	putative active site [active]
438753014815	putative CoA binding site [chemical binding]; other site
438753014816	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
438753014817	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
438753014818	Walker A/P-loop; other site
438753014819	ATP binding site [chemical binding]; other site
438753014820	Q-loop/lid; other site
438753014821	ABC transporter signature motif; other site
438753014822	Walker B; other site
438753014823	D-loop; other site
438753014824	H-loop/switch region; other site
438753014825	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753014826	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753014827	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
438753014828	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
438753014829	enoyl-CoA hydratase; Provisional; Region: PRK05995
438753014830	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
438753014831	substrate binding site [chemical binding]; other site
438753014832	oxyanion hole (OAH) forming residues; other site
438753014833	trimer interface [polypeptide binding]; other site
438753014834	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
438753014835	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
438753014836	ATP-grasp domain; Region: ATP-grasp_4; cl17255
438753014837	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
438753014838	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
438753014839	carboxyltransferase (CT) interaction site; other site
438753014840	biotinylation site [posttranslational modification]; other site
438753014841	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
438753014842	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
438753014843	catalytic triad [active]
438753014844	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
438753014845	EamA-like transporter family; Region: EamA; pfam00892
438753014846	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
438753014847	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
438753014848	active site
438753014849	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
438753014850	EamA-like transporter family; Region: EamA; pfam00892
438753014851	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753014852	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
438753014853	dimerization interface [polypeptide binding]; other site
438753014854	Glucokinase; Region: Glucokinase; cl17310
438753014855	glucokinase, proteobacterial type; Region: glk; TIGR00749
438753014856	Tim44-like domain; Region: Tim44; pfam04280
438753014857	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
438753014858	MltA specific insert domain; Region: MltA; smart00925
438753014859	3D domain; Region: 3D; pfam06725
438753014860	Smr domain; Region: Smr; pfam01713
438753014861	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
438753014862	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753014863	non-specific DNA binding site [nucleotide binding]; other site
438753014864	salt bridge; other site
438753014865	sequence-specific DNA binding site [nucleotide binding]; other site
438753014866	PRC-barrel domain; Region: PRC; pfam05239
438753014867	PRC-barrel domain; Region: PRC; pfam05239
438753014868	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
438753014869	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
438753014870	active site
438753014871	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
438753014872	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
438753014873	Walker A/P-loop; other site
438753014874	ATP binding site [chemical binding]; other site
438753014875	Q-loop/lid; other site
438753014876	ABC transporter signature motif; other site
438753014877	Walker B; other site
438753014878	D-loop; other site
438753014879	H-loop/switch region; other site
438753014880	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
438753014881	Uncharacterized conserved protein [Function unknown]; Region: COG1434
438753014882	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
438753014883	putative active site [active]
438753014884	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
438753014885	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
438753014886	putative acyl-acceptor binding pocket; other site
438753014887	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
438753014888	putative active site pocket [active]
438753014889	dimerization interface [polypeptide binding]; other site
438753014890	putative catalytic residue [active]
438753014891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
438753014892	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
438753014893	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
438753014894	prephenate dehydrogenase; Validated; Region: PRK08507
438753014895	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
438753014896	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753014897	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753014898	homodimer interface [polypeptide binding]; other site
438753014899	catalytic residue [active]
438753014900	hypothetical protein; Provisional; Region: PRK06034
438753014901	Chorismate mutase type II; Region: CM_2; pfam01817
438753014902	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
438753014903	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
438753014904	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
438753014905	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
438753014906	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
438753014907	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
438753014908	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
438753014909	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
438753014910	guanine deaminase; Provisional; Region: PRK09228
438753014911	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
438753014912	active site
438753014913	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
438753014914	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
438753014915	DXD motif; other site
438753014916	Bacterial sugar transferase; Region: Bac_transf; pfam02397
438753014917	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
438753014918	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753014919	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
438753014920	anti sigma factor interaction site; other site
438753014921	regulatory phosphorylation site [posttranslational modification]; other site
438753014922	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
438753014923	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
438753014924	SLBB domain; Region: SLBB; pfam10531
438753014925	SLBB domain; Region: SLBB; pfam10531
438753014926	SLBB domain; Region: SLBB; pfam10531
438753014927	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
438753014928	SLBB domain; Region: SLBB; pfam10531
438753014929	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
438753014930	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
438753014931	Chain length determinant protein; Region: Wzz; cl15801
438753014932	Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751
438753014933	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753014934	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
438753014935	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
438753014936	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753014937	putative homodimer interface [polypeptide binding]; other site
438753014938	O-Antigen ligase; Region: Wzy_C; cl04850
438753014939	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
438753014940	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
438753014941	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
438753014942	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
438753014943	active site
438753014944	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
438753014945	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
438753014946	quinone interaction residues [chemical binding]; other site
438753014947	active site
438753014948	catalytic residues [active]
438753014949	FMN binding site [chemical binding]; other site
438753014950	substrate binding site [chemical binding]; other site
438753014951	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
438753014952	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
438753014953	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
438753014954	active site 1 [active]
438753014955	dimer interface [polypeptide binding]; other site
438753014956	active site 2 [active]
438753014957	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
438753014958	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
438753014959	dimer interface [polypeptide binding]; other site
438753014960	active site
438753014961	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
438753014962	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
438753014963	NAD binding site [chemical binding]; other site
438753014964	homotetramer interface [polypeptide binding]; other site
438753014965	homodimer interface [polypeptide binding]; other site
438753014966	substrate binding site [chemical binding]; other site
438753014967	active site
438753014968	transcription elongation factor regulatory protein; Validated; Region: PRK06342
438753014969	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
438753014970	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
438753014971	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
438753014972	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
438753014973	non-specific DNA binding site [nucleotide binding]; other site
438753014974	salt bridge; other site
438753014975	sequence-specific DNA binding site [nucleotide binding]; other site
438753014976	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
438753014977	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
438753014978	active site
438753014979	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
438753014980	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
438753014981	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
438753014982	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
438753014983	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
438753014984	FeS/SAM binding site; other site
438753014985	HemN C-terminal domain; Region: HemN_C; pfam06969
438753014986	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
438753014987	ligand binding site [chemical binding]; other site
438753014988	flexible hinge region; other site
438753014989	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
438753014990	putative switch regulator; other site
438753014991	non-specific DNA interactions [nucleotide binding]; other site
438753014992	DNA binding site [nucleotide binding]
438753014993	sequence specific DNA binding site [nucleotide binding]; other site
438753014994	putative cAMP binding site [chemical binding]; other site
438753014995	PAS domain S-box; Region: sensory_box; TIGR00229
438753014996	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753014997	putative active site [active]
438753014998	heme pocket [chemical binding]; other site
438753014999	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753015000	dimer interface [polypeptide binding]; other site
438753015001	phosphorylation site [posttranslational modification]
438753015002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753015003	ATP binding site [chemical binding]; other site
438753015004	Mg2+ binding site [ion binding]; other site
438753015005	G-X-G motif; other site
438753015006	response regulator FixJ; Provisional; Region: fixJ; PRK09390
438753015007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753015008	active site
438753015009	phosphorylation site [posttranslational modification]
438753015010	intermolecular recognition site; other site
438753015011	dimerization interface [polypeptide binding]; other site
438753015012	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
438753015013	DNA binding residues [nucleotide binding]
438753015014	dimerization interface [polypeptide binding]; other site
438753015015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753015016	Response regulator receiver domain; Region: Response_reg; pfam00072
438753015017	active site
438753015018	phosphorylation site [posttranslational modification]
438753015019	intermolecular recognition site; other site
438753015020	dimerization interface [polypeptide binding]; other site
438753015021	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
438753015022	CoA binding domain; Region: CoA_binding_2; pfam13380
438753015023	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
438753015024	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
438753015025	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
438753015026	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
438753015027	Coenzyme A binding pocket [chemical binding]; other site
438753015028	CHASE4 domain; Region: CHASE4; pfam05228
438753015029	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
438753015030	PAS domain; Region: PAS_9; pfam13426
438753015031	putative active site [active]
438753015032	heme pocket [chemical binding]; other site
438753015033	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
438753015034	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
438753015035	metal binding site [ion binding]; metal-binding site
438753015036	active site
438753015037	I-site; other site
438753015038	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
438753015039	diaminopimelate decarboxylase; Region: lysA; TIGR01048
438753015040	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
438753015041	active site
438753015042	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
438753015043	substrate binding site [chemical binding]; other site
438753015044	catalytic residues [active]
438753015045	dimer interface [polypeptide binding]; other site
438753015046	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
438753015047	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
438753015048	putative FMN binding site [chemical binding]; other site
438753015049	argininosuccinate lyase; Provisional; Region: PRK00855
438753015050	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
438753015051	active sites [active]
438753015052	tetramer interface [polypeptide binding]; other site
438753015053	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
438753015054	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
438753015055	catalytic residues [active]
438753015056	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
438753015057	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
438753015058	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
438753015059	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
438753015060	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
438753015061	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
438753015062	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
438753015063	Ligand binding site [chemical binding]; other site
438753015064	Electron transfer flavoprotein domain; Region: ETF; pfam01012
438753015065	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
438753015066	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
438753015067	HlyD family secretion protein; Region: HlyD_3; pfam13437
438753015068	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
438753015069	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
438753015070	Walker A/P-loop; other site
438753015071	ATP binding site [chemical binding]; other site
438753015072	Q-loop/lid; other site
438753015073	ABC transporter signature motif; other site
438753015074	Walker B; other site
438753015075	D-loop; other site
438753015076	H-loop/switch region; other site
438753015077	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
438753015078	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
438753015079	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
438753015080	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
438753015081	GDP-binding site [chemical binding]; other site
438753015082	ACT binding site; other site
438753015083	IMP binding site; other site
438753015084	preprotein translocase subunit SecB; Validated; Region: PRK05751
438753015085	SecA binding site; other site
438753015086	Preprotein binding site; other site
438753015087	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
438753015088	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
438753015089	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
438753015090	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
438753015091	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
438753015092	C-terminal domain interface [polypeptide binding]; other site
438753015093	GSH binding site (G-site) [chemical binding]; other site
438753015094	dimer interface [polypeptide binding]; other site
438753015095	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
438753015096	N-terminal domain interface [polypeptide binding]; other site
438753015097	dimer interface [polypeptide binding]; other site
438753015098	substrate binding pocket (H-site) [chemical binding]; other site
438753015099	epoxyqueuosine reductase; Region: TIGR00276
438753015100	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
438753015101	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
438753015102	NAD(P) binding site [chemical binding]; other site
438753015103	active site
438753015104	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
438753015105	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
438753015106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753015107	ATP binding site [chemical binding]; other site
438753015108	Mg2+ binding site [ion binding]; other site
438753015109	G-X-G motif; other site
438753015110	Response regulator receiver domain; Region: Response_reg; pfam00072
438753015111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753015112	active site
438753015113	phosphorylation site [posttranslational modification]
438753015114	intermolecular recognition site; other site
438753015115	dimerization interface [polypeptide binding]; other site
438753015116	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
438753015117	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
438753015118	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
438753015119	active site
438753015120	metal binding site [ion binding]; metal-binding site
438753015121	HTH domain; Region: HTH_11; pfam08279
438753015122	Predicted transcriptional regulator [Transcription]; Region: COG2378
438753015123	WYL domain; Region: WYL; pfam13280
438753015124	Domain of unknown function (DUF336); Region: DUF336; cl01249
438753015125	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
438753015126	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
438753015127	Transcriptional regulator [Transcription]; Region: LysR; COG0583
438753015128	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
438753015129	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
438753015130	putative effector binding pocket; other site
438753015131	dimerization interface [polypeptide binding]; other site
438753015132	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
438753015133	putative FMN binding site [chemical binding]; other site
438753015134	aspartate aminotransferase; Provisional; Region: PRK06108
438753015135	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
438753015136	pyridoxal 5'-phosphate binding site [chemical binding]; other site
438753015137	homodimer interface [polypeptide binding]; other site
438753015138	catalytic residue [active]
438753015139	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
438753015140	Putative ammonia monooxygenase; Region: AmoA; pfam05145
438753015141	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
438753015142	Predicted membrane protein [Function unknown]; Region: COG2259
438753015143	Protein of unknown function DUF45; Region: DUF45; pfam01863
438753015144	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
438753015145	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
438753015146	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
438753015147	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
438753015148	dimer interface [polypeptide binding]; other site
438753015149	phosphorylation site [posttranslational modification]
438753015150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
438753015151	ATP binding site [chemical binding]; other site
438753015152	Mg2+ binding site [ion binding]; other site
438753015153	G-X-G motif; other site
438753015154	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
438753015155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
438753015156	active site
438753015157	phosphorylation site [posttranslational modification]
438753015158	intermolecular recognition site; other site
438753015159	dimerization interface [polypeptide binding]; other site
438753015160	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
438753015161	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
438753015162	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
438753015163	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
438753015164	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
438753015165	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
438753015166	transmembrane helices; other site
438753015167	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
438753015168	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
438753015169	purine monophosphate binding site [chemical binding]; other site
438753015170	dimer interface [polypeptide binding]; other site
438753015171	putative catalytic residues [active]
438753015172	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
438753015173	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
438753015174	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
438753015175	NusB family; Region: NusB; pfam01029
438753015176	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
438753015177	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
438753015178	S-adenosylmethionine binding site [chemical binding]; other site
438753015179	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
438753015180	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
438753015181	Predicted acyl esterases [General function prediction only]; Region: COG2936
438753015182	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
438753015183	heat shock protein HtpX; Provisional; Region: PRK01345
438753015184	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
438753015185	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
438753015186	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
438753015187	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
438753015188	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
438753015189	Glycoprotease family; Region: Peptidase_M22; pfam00814
438753015190	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
438753015191	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
438753015192	dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361
438753015193	DAK2 domain; Region: Dak2; pfam02734
438753015194	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
438753015195	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
438753015196	catalytic residues [active]
438753015197	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
438753015198	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
438753015199	trmE is a tRNA modification GTPase; Region: trmE; cd04164
438753015200	G1 box; other site
438753015201	GTP/Mg2+ binding site [chemical binding]; other site
438753015202	Switch I region; other site
438753015203	G2 box; other site
438753015204	Switch II region; other site
438753015205	G3 box; other site
438753015206	G4 box; other site
438753015207	G5 box; other site
438753015208	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
438753015209	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
438753015210	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
438753015211	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
438753015212	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
438753015213	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
438753015214	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
438753015215	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
438753015216	P-loop; other site
438753015217	Magnesium ion binding site [ion binding]; other site
438753015218	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
438753015219	Magnesium ion binding site [ion binding]; other site
438753015220	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
438753015221	ParB-like nuclease domain; Region: ParBc; pfam02195
438753015222	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
438753015223	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
438753015224	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
438753015225	MutS domain I; Region: MutS_I; pfam01624
438753015226	MutS domain II; Region: MutS_II; pfam05188
438753015227	MutS domain III; Region: MutS_III; pfam05192
438753015228	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
438753015229	Walker A/P-loop; other site
438753015230	ATP binding site [chemical binding]; other site
438753015231	Q-loop/lid; other site
438753015232	ABC transporter signature motif; other site
438753015233	Walker B; other site
438753015234	D-loop; other site
438753015235	H-loop/switch region; other site
438753015236	transcription termination factor Rho; Provisional; Region: rho; PRK09376
438753015237	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
438753015238	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
438753015239	RNA binding site [nucleotide binding]; other site
438753015240	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
438753015241	multimer interface [polypeptide binding]; other site
438753015242	Walker A motif; other site
438753015243	ATP binding site [chemical binding]; other site
438753015244	Walker B motif; other site
438753015245	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
438753015246	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
438753015247	substrate binding site [chemical binding]; other site
438753015248	active site