-- dump date   	20140618_205632
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
696747000001	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
696747000002	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
696747000003	ligand binding site; other site
696747000004	tetramer interface; other site
696747000005	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
696747000006	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
696747000007	active site
696747000008	catalytic residues [active]
696747000009	metal binding site [ion binding]; metal-binding site
696747000010	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747000011	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000012	TPR motif; other site
696747000013	binding surface
696747000014	TPR repeat; Region: TPR_11; pfam13414
696747000015	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000016	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747000017	binding surface
696747000018	TPR motif; other site
696747000019	chaperone protein DnaJ; Provisional; Region: PRK14286
696747000020	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
696747000021	HSP70 interaction site [polypeptide binding]; other site
696747000022	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
696747000023	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
696747000024	HSP70 interaction site [polypeptide binding]; other site
696747000025	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
696747000026	hypothetical protein; Provisional; Region: PRK12705
696747000027	TPR repeat; Region: TPR_11; pfam13414
696747000028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000029	binding surface
696747000030	TPR motif; other site
696747000031	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
696747000032	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
696747000033	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
696747000034	synthase/transferase; Region: PLN02316
696747000035	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747000036	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000037	TPR motif; other site
696747000038	binding surface
696747000039	TPR repeat; Region: TPR_11; pfam13414
696747000040	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000041	binding surface
696747000042	TPR motif; other site
696747000043	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747000044	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
696747000045	Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182
696747000046	putative active site [active]
696747000047	metal binding site [ion binding]; metal-binding site
696747000048	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
696747000049	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
696747000050	PYR/PP interface [polypeptide binding]; other site
696747000051	dimer interface [polypeptide binding]; other site
696747000052	TPP binding site [chemical binding]; other site
696747000053	Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371
696747000054	TPP-binding site; other site
696747000055	cytidylyltransferase; Region: cytidylyltransferase; cd02170
696747000056	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
696747000057	active site
696747000058	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
696747000059	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
696747000060	tetramer interface [polypeptide binding]; other site
696747000061	active site
696747000062	Mg2+/Mn2+ binding site [ion binding]; other site
696747000063	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747000064	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000065	TPR motif; other site
696747000066	binding surface
696747000067	Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493
696747000068	YcfA-like protein; Region: YcfA; cl00752
696747000069	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
696747000070	Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493
696747000071	YcfA-like protein; Region: YcfA; cl00752
696747000072	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
696747000073	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
696747000074	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000075	binding surface
696747000076	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747000077	TPR motif; other site
696747000078	TPR repeat; Region: TPR_11; pfam13414
696747000079	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000080	binding surface
696747000081	TPR motif; other site
696747000082	TPR repeat; Region: TPR_11; pfam13414
696747000083	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
696747000084	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747000085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
696747000086	TPR repeat; Region: TPR_11; pfam13414
696747000087	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000088	binding surface
696747000089	TPR motif; other site
696747000090	TPR repeat; Region: TPR_11; pfam13414
696747000091	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000092	TPR motif; other site
696747000093	TPR repeat; Region: TPR_11; pfam13414
696747000094	binding surface
696747000095	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000096	binding surface
696747000097	TPR motif; other site
696747000098	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
696747000099	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696747000100	Protein of unknown function (DUF616); Region: DUF616; pfam04765
696747000101	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
696747000102	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
696747000103	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696747000104	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747000105	104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449
696747000106	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747000107	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747000108	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747000109	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747000110	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747000111	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747000112	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747000113	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747000114	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747000115	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747000116	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747000117	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747000118	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747000119	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747000120	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747000121	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747000122	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747000123	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747000124	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747000125	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747000126	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747000127	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747000128	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747000129	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747000130	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000131	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747000132	TPR motif; other site
696747000133	binding surface
696747000134	Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364
696747000135	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000136	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747000137	binding surface
696747000138	TPR motif; other site
696747000139	Caenorhabditis protein of unknown function, DUF268; Region: DUF268; pfam03269
696747000140	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747000141	Methyltransferase domain; Region: Methyltransf_12; pfam08242
696747000142	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
696747000143	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
696747000144	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696747000145	NAD binding site [chemical binding]; other site
696747000146	homotetramer interface [polypeptide binding]; other site
696747000147	homodimer interface [polypeptide binding]; other site
696747000148	active site
696747000149	substrate binding site [chemical binding]; other site
696747000150	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000151	binding surface
696747000152	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747000153	TPR motif; other site
696747000154	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747000155	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000156	binding surface
696747000157	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747000158	TPR motif; other site
696747000159	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747000160	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
696747000161	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
696747000162	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747000163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747000164	S-adenosylmethionine binding site [chemical binding]; other site
696747000165	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000166	binding surface
696747000167	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747000168	TPR motif; other site
696747000169	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747000170	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696747000171	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747000172	active site
696747000173	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
696747000174	C factor cell-cell signaling protein; Provisional; Region: PRK09009
696747000175	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
696747000176	NADP binding site [chemical binding]; other site
696747000177	homodimer interface [polypeptide binding]; other site
696747000178	active site
696747000179	Domain of unknown function DUF21; Region: DUF21; pfam01595
696747000180	FOG: CBS domain [General function prediction only]; Region: COG0517
696747000181	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
696747000182	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747000183	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
696747000184	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747000185	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
696747000186	putative ADP-binding pocket [chemical binding]; other site
696747000187	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
696747000188	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747000189	active site
696747000190	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
696747000191	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
696747000192	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
696747000193	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
696747000194	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
696747000195	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
696747000196	P loop; other site
696747000197	Nucleotide binding site [chemical binding]; other site
696747000198	DTAP/Switch II; other site
696747000199	Switch I; other site
696747000200	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
696747000201	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
696747000202	DTAP/Switch II; other site
696747000203	Switch I; other site
696747000204	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
696747000205	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
696747000206	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
696747000207	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
696747000208	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696747000209	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
696747000210	catalytic triad [active]
696747000211	M28 Zn-Peptidases; Region: M28_like_1; cd05640
696747000212	Peptidase family M28; Region: Peptidase_M28; pfam04389
696747000213	metal binding site [ion binding]; metal-binding site
696747000214	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696747000215	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747000216	S-adenosylmethionine binding site [chemical binding]; other site
696747000217	phycobillisome linker protein; Region: apcE; CHL00091
696747000218	Phycobilisome protein; Region: Phycobilisome; cl08227
696747000219	Phycobilisome protein; Region: Phycobilisome; cl08227
696747000220	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
696747000221	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
696747000222	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
696747000223	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
696747000224	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
696747000225	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
696747000226	anti sigma factor interaction site; other site
696747000227	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
696747000228	regulatory phosphorylation site [posttranslational modification]; other site
696747000229	Protein-arginine deiminase (PAD); Region: PAD; pfam03068
696747000230	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
696747000231	Domain of unknown function DUF20; Region: UPF0118; pfam01594
696747000232	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
696747000233	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
696747000234	dimer interface [polypeptide binding]; other site
696747000235	catalytic triad [active]
696747000236	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
696747000237	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
696747000238	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
696747000239	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
696747000240	active site
696747000241	catalytic site [active]
696747000242	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
696747000243	TLC ATP/ADP transporter; Region: TLC; cl03940
696747000244	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696747000245	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
696747000246	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696747000247	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747000248	ligand binding site [chemical binding]; other site
696747000249	flexible hinge region; other site
696747000250	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
696747000251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696747000252	putative substrate translocation pore; other site
696747000253	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
696747000254	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
696747000255	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
696747000256	Uncharacterized conserved protein [Function unknown]; Region: COG0397
696747000257	hypothetical protein; Validated; Region: PRK00029
696747000258	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
696747000259	Mechanosensitive ion channel; Region: MS_channel; pfam00924
696747000260	MarR family; Region: MarR_2; pfam12802
696747000261	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
696747000262	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
696747000263	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
696747000264	active site
696747000265	catalytic site [active]
696747000266	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
696747000267	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
696747000268	Ligand Binding Site [chemical binding]; other site
696747000269	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
696747000270	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
696747000271	Ligand binding site; other site
696747000272	Putative Catalytic site; other site
696747000273	DXD motif; other site
696747000274	2-isopropylmalate synthase; Validated; Region: PRK00915
696747000275	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
696747000276	active site
696747000277	catalytic residues [active]
696747000278	metal binding site [ion binding]; metal-binding site
696747000279	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
696747000280	Uncharacterized conserved protein [Function unknown]; Region: COG1432
696747000281	LabA_like proteins; Region: LabA; cd10911
696747000282	putative metal binding site [ion binding]; other site
696747000283	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
696747000284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747000285	active site
696747000286	phosphorylation site [posttranslational modification]
696747000287	intermolecular recognition site; other site
696747000288	dimerization interface [polypeptide binding]; other site
696747000289	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696747000290	DNA binding residues [nucleotide binding]
696747000291	dimerization interface [polypeptide binding]; other site
696747000292	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
696747000293	dimer interface [polypeptide binding]; other site
696747000294	[2Fe-2S] cluster binding site [ion binding]; other site
696747000295	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
696747000296	oligomerisation interface [polypeptide binding]; other site
696747000297	mobile loop; other site
696747000298	roof hairpin; other site
696747000299	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
696747000300	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
696747000301	ring oligomerisation interface [polypeptide binding]; other site
696747000302	ATP/Mg binding site [chemical binding]; other site
696747000303	stacking interactions; other site
696747000304	hinge regions; other site
696747000305	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
696747000306	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
696747000307	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
696747000308	active site
696747000309	catalytic site [active]
696747000310	substrate binding site [chemical binding]; other site
696747000311	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747000312	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
696747000313	Walker A motif; other site
696747000314	ATP binding site [chemical binding]; other site
696747000315	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
696747000316	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747000317	RNA helicase; Region: RNA_helicase; pfam00910
696747000318	Walker A motif; other site
696747000319	ATP binding site [chemical binding]; other site
696747000320	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
696747000321	active site
696747000322	putative DNA-binding cleft [nucleotide binding]; other site
696747000323	dimer interface [polypeptide binding]; other site
696747000324	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
696747000325	active site
696747000326	catalytic residues [active]
696747000327	metal binding site [ion binding]; metal-binding site
696747000328	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
696747000329	Lipase (class 2); Region: Lipase_2; pfam01674
696747000330	Integral membrane protein DUF92; Region: DUF92; pfam01940
696747000331	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
696747000332	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
696747000333	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
696747000334	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
696747000335	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
696747000336	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
696747000337	Psb28 protein; Region: Psb28; pfam03912
696747000338	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
696747000339	nudix motif; other site
696747000340	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
696747000341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
696747000342	TPR motif; other site
696747000343	binding surface
696747000344	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
696747000345	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
696747000346	Walker A/P-loop; other site
696747000347	ATP binding site [chemical binding]; other site
696747000348	Q-loop/lid; other site
696747000349	ABC transporter signature motif; other site
696747000350	Walker B; other site
696747000351	D-loop; other site
696747000352	H-loop/switch region; other site
696747000353	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
696747000354	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
696747000355	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
696747000356	homotrimer interaction site [polypeptide binding]; other site
696747000357	active site
696747000358	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
696747000359	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
696747000360	tandem repeat interface [polypeptide binding]; other site
696747000361	oligomer interface [polypeptide binding]; other site
696747000362	active site residues [active]
696747000363	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
696747000364	EamA-like transporter family; Region: EamA; pfam00892
696747000365	EamA-like transporter family; Region: EamA; pfam00892
696747000366	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
696747000367	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
696747000368	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
696747000369	catalytic site [active]
696747000370	active site
696747000371	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
696747000372	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
696747000373	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
696747000374	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
696747000375	active site
696747000376	catalytic site [active]
696747000377	hypothetical protein; Reviewed; Region: PRK00024
696747000378	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
696747000379	MPN+ (JAMM) motif; other site
696747000380	Zinc-binding site [ion binding]; other site
696747000381	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747000382	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
696747000383	putative ADP-binding pocket [chemical binding]; other site
696747000384	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747000385	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
696747000386	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
696747000387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747000388	S-adenosylmethionine binding site [chemical binding]; other site
696747000389	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747000390	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747000391	Predicted flavoprotein [General function prediction only]; Region: COG0431
696747000392	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
696747000393	Pirin-related protein [General function prediction only]; Region: COG1741
696747000394	Pirin; Region: Pirin; pfam02678
696747000395	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
696747000396	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696747000397	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747000398	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747000399	S-adenosylmethionine binding site [chemical binding]; other site
696747000400	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747000401	S-adenosylmethionine binding site [chemical binding]; other site
696747000402	LysE type translocator; Region: LysE; cl00565
696747000403	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
696747000404	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
696747000405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747000406	S-adenosylmethionine binding site [chemical binding]; other site
696747000407	Peptidase family U32; Region: Peptidase_U32; pfam01136
696747000408	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
696747000409	Peptidase family U32; Region: Peptidase_U32; pfam01136
696747000410	S-layer homology domain; Region: SLH; pfam00395
696747000411	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
696747000412	classical (c) SDRs; Region: SDR_c; cd05233
696747000413	NAD(P) binding site [chemical binding]; other site
696747000414	active site
696747000415	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
696747000416	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
696747000417	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696747000418	catalytic residue [active]
696747000419	Ion transport protein; Region: Ion_trans; pfam00520
696747000420	Ion channel; Region: Ion_trans_2; pfam07885
696747000421	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
696747000422	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747000423	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
696747000424	protein binding site [polypeptide binding]; other site
696747000425	chaperone protein DnaJ; Provisional; Region: PRK14299
696747000426	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
696747000427	HSP70 interaction site [polypeptide binding]; other site
696747000428	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
696747000429	substrate binding site [polypeptide binding]; other site
696747000430	dimer interface [polypeptide binding]; other site
696747000431	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
696747000432	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
696747000433	putative dimer interface [polypeptide binding]; other site
696747000434	methionine sulfoxide reductase B; Provisional; Region: PRK00222
696747000435	SelR domain; Region: SelR; pfam01641
696747000436	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
696747000437	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
696747000438	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696747000439	Ligand Binding Site [chemical binding]; other site
696747000440	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
696747000441	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
696747000442	Malic enzyme, N-terminal domain; Region: malic; pfam00390
696747000443	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
696747000444	putative NAD(P) binding site [chemical binding]; other site
696747000445	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
696747000446	ligand-binding site [chemical binding]; other site
696747000447	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
696747000448	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696747000449	active site
696747000450	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696747000451	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696747000452	salt bridge; other site
696747000453	non-specific DNA binding site [nucleotide binding]; other site
696747000454	sequence-specific DNA binding site [nucleotide binding]; other site
696747000455	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747000456	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
696747000457	putative ADP-binding pocket [chemical binding]; other site
696747000458	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
696747000459	dimer interface [polypeptide binding]; other site
696747000460	[2Fe-2S] cluster binding site [ion binding]; other site
696747000461	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
696747000462	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747000463	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
696747000464	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
696747000465	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
696747000466	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
696747000467	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
696747000468	AMP binding site [chemical binding]; other site
696747000469	metal binding site [ion binding]; metal-binding site
696747000470	active site
696747000471	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
696747000472	amidase catalytic site [active]
696747000473	Zn binding residues [ion binding]; other site
696747000474	substrate binding site [chemical binding]; other site
696747000475	TraB family; Region: TraB; pfam01963
696747000476	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
696747000477	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
696747000478	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
696747000479	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
696747000480	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
696747000481	Short C-terminal domain; Region: SHOCT; pfam09851
696747000482	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
696747000483	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
696747000484	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
696747000485	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
696747000486	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
696747000487	short chain dehydrogenase; Provisional; Region: PRK12367
696747000488	NAD(P) binding site [chemical binding]; other site
696747000489	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
696747000490	nudix motif; other site
696747000491	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
696747000492	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747000493	primosomal protein N' Region: priA; TIGR00595
696747000494	ATP binding site [chemical binding]; other site
696747000495	putative Mg++ binding site [ion binding]; other site
696747000496	helicase superfamily c-terminal domain; Region: HELICc; smart00490
696747000497	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
696747000498	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
696747000499	active site
696747000500	Substrate binding site; other site
696747000501	Mg++ binding site; other site
696747000502	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
696747000503	putative trimer interface [polypeptide binding]; other site
696747000504	putative CoA binding site [chemical binding]; other site
696747000505	CHAT domain; Region: CHAT; cl17868
696747000506	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747000507	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747000508	phosphopeptide binding site; other site
696747000509	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
696747000510	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
696747000511	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
696747000512	active site
696747000513	catalytic site [active]
696747000514	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
696747000515	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
696747000516	ATP binding site [chemical binding]; other site
696747000517	active site
696747000518	substrate binding site [chemical binding]; other site
696747000519	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
696747000520	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
696747000521	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
696747000522	Surface antigen; Region: Bac_surface_Ag; pfam01103
696747000523	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
696747000524	DNA protecting protein DprA; Region: dprA; TIGR00732
696747000525	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
696747000526	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747000527	nucleotide binding region [chemical binding]; other site
696747000528	ATP-binding site [chemical binding]; other site
696747000529	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
696747000530	DEAD/DEAH box helicase; Region: DEAD; pfam00270
696747000531	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
696747000532	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
696747000533	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
696747000534	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696747000535	Zn2+ binding site [ion binding]; other site
696747000536	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
696747000537	G1 box; other site
696747000538	GTP/Mg2+ binding site [chemical binding]; other site
696747000539	G2 box; other site
696747000540	Switch I region; other site
696747000541	G3 box; other site
696747000542	Switch II region; other site
696747000543	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
696747000544	NurA nuclease; Region: NurA; smart00933
696747000545	PAS fold; Region: PAS_2; pfam08446
696747000546	GAF domain; Region: GAF; pfam01590
696747000547	Phytochrome region; Region: PHY; pfam00360
696747000548	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747000549	dimer interface [polypeptide binding]; other site
696747000550	phosphorylation site [posttranslational modification]
696747000551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747000552	ATP binding site [chemical binding]; other site
696747000553	Mg2+ binding site [ion binding]; other site
696747000554	G-X-G motif; other site
696747000555	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747000556	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747000557	active site
696747000558	phosphorylation site [posttranslational modification]
696747000559	intermolecular recognition site; other site
696747000560	dimerization interface [polypeptide binding]; other site
696747000561	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
696747000562	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
696747000563	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
696747000564	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
696747000565	Conserved TM helix; Region: TM_helix; pfam05552
696747000566	Conserved TM helix; Region: TM_helix; pfam05552
696747000567	Conserved TM helix; Region: TM_helix; pfam05552
696747000568	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
696747000569	hydrophobic ligand binding site; other site
696747000570	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
696747000571	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
696747000572	active site
696747000573	Int/Topo IB signature motif; other site
696747000574	DNA binding site [nucleotide binding]
696747000575	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
696747000576	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
696747000577	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
696747000578	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747000579	Uncharacterized conserved protein [Function unknown]; Region: COG2912
696747000580	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
696747000581	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000582	binding surface
696747000583	TPR motif; other site
696747000584	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
696747000585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747000586	ATP binding site [chemical binding]; other site
696747000587	Mg2+ binding site [ion binding]; other site
696747000588	G-X-G motif; other site
696747000589	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
696747000590	ATP binding site [chemical binding]; other site
696747000591	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
696747000592	PetN; Region: PetN; pfam03742
696747000593	NMT1/THI5 like; Region: NMT1; pfam09084
696747000594	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
696747000595	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
696747000596	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
696747000597	lipoprotein signal peptidase; Provisional; Region: PRK14787
696747000598	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
696747000599	biotin synthase; Region: bioB; TIGR00433
696747000600	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747000601	FeS/SAM binding site; other site
696747000602	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
696747000603	PBP superfamily domain; Region: PBP_like_2; cl17296
696747000604	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
696747000605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747000606	dimer interface [polypeptide binding]; other site
696747000607	conserved gate region; other site
696747000608	putative PBP binding loops; other site
696747000609	ABC-ATPase subunit interface; other site
696747000610	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
696747000611	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747000612	dimer interface [polypeptide binding]; other site
696747000613	conserved gate region; other site
696747000614	putative PBP binding loops; other site
696747000615	ABC-ATPase subunit interface; other site
696747000616	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
696747000617	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
696747000618	Walker A/P-loop; other site
696747000619	ATP binding site [chemical binding]; other site
696747000620	Q-loop/lid; other site
696747000621	ABC transporter signature motif; other site
696747000622	Walker B; other site
696747000623	D-loop; other site
696747000624	H-loop/switch region; other site
696747000625	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
696747000626	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
696747000627	Walker A/P-loop; other site
696747000628	ATP binding site [chemical binding]; other site
696747000629	Q-loop/lid; other site
696747000630	ABC transporter signature motif; other site
696747000631	Walker B; other site
696747000632	D-loop; other site
696747000633	H-loop/switch region; other site
696747000634	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
696747000635	CpeS-like protein; Region: CpeS; pfam09367
696747000636	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
696747000637	putative active site [active]
696747000638	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747000639	putative active site [active]
696747000640	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
696747000641	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
696747000642	oligomeric interface; other site
696747000643	putative active site [active]
696747000644	homodimer interface [polypeptide binding]; other site
696747000645	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
696747000646	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
696747000647	putative active site [active]
696747000648	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
696747000649	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
696747000650	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747000651	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
696747000652	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747000653	structural tetrad; other site
696747000654	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747000655	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747000656	structural tetrad; other site
696747000657	WD40 repeats; Region: WD40; smart00320
696747000658	TPR repeat; Region: TPR_11; pfam13414
696747000659	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000660	binding surface
696747000661	TPR motif; other site
696747000662	TPR repeat; Region: TPR_11; pfam13414
696747000663	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000664	binding surface
696747000665	TPR motif; other site
696747000666	TPR repeat; Region: TPR_11; pfam13414
696747000667	AAA ATPase domain; Region: AAA_16; pfam13191
696747000668	AAA domain; Region: AAA_22; pfam13401
696747000669	TPR repeat; Region: TPR_11; pfam13414
696747000670	Tetratricopeptide repeat; Region: TPR_1; pfam00515
696747000671	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000672	binding surface
696747000673	TPR repeat; Region: TPR_11; pfam13414
696747000674	TPR motif; other site
696747000675	Tetratricopeptide repeat; Region: TPR_9; pfam13371
696747000676	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
696747000677	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747000678	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747000679	dimer interface [polypeptide binding]; other site
696747000680	phosphorylation site [posttranslational modification]
696747000681	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
696747000682	UbiA prenyltransferase family; Region: UbiA; pfam01040
696747000683	TPR repeat; Region: TPR_11; pfam13414
696747000684	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000685	binding surface
696747000686	TPR motif; other site
696747000687	TPR repeat; Region: TPR_11; pfam13414
696747000688	TPR repeat; Region: TPR_11; pfam13414
696747000689	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000690	binding surface
696747000691	TPR motif; other site
696747000692	TPR repeat; Region: TPR_11; pfam13414
696747000693	TPR repeat; Region: TPR_11; pfam13414
696747000694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000695	binding surface
696747000696	TPR motif; other site
696747000697	TPR repeat; Region: TPR_11; pfam13414
696747000698	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
696747000699	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
696747000700	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
696747000701	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
696747000702	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
696747000703	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
696747000704	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
696747000705	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
696747000706	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
696747000707	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
696747000708	S-layer homology domain; Region: SLH; pfam00395
696747000709	S-layer homology domain; Region: SLH; pfam00395
696747000710	S-layer homology domain; Region: SLH; pfam00395
696747000711	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
696747000712	C-terminal peptidase (prc); Region: prc; TIGR00225
696747000713	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
696747000714	protein binding site [polypeptide binding]; other site
696747000715	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
696747000716	Catalytic dyad [active]
696747000717	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696747000718	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747000719	active site
696747000720	phosphorylation site [posttranslational modification]
696747000721	intermolecular recognition site; other site
696747000722	dimerization interface [polypeptide binding]; other site
696747000723	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747000724	DNA binding site [nucleotide binding]
696747000725	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
696747000726	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
696747000727	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
696747000728	Mechanosensitive ion channel; Region: MS_channel; pfam00924
696747000729	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696747000730	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747000731	ligand binding site [chemical binding]; other site
696747000732	flexible hinge region; other site
696747000733	Transposase IS200 like; Region: Y1_Tnp; pfam01797
696747000734	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
696747000735	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
696747000736	active site
696747000737	tellurite resistance protein terB; Region: terB; cd07176
696747000738	putative metal binding site [ion binding]; other site
696747000739	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
696747000740	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
696747000741	Hexamer interface [polypeptide binding]; other site
696747000742	Hexagonal pore residue; other site
696747000743	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
696747000744	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
696747000745	Hexamer interface [polypeptide binding]; other site
696747000746	Hexagonal pore residue; other site
696747000747	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
696747000748	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
696747000749	putative dimer interface [polypeptide binding]; other site
696747000750	putative anticodon binding site; other site
696747000751	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
696747000752	homodimer interface [polypeptide binding]; other site
696747000753	motif 1; other site
696747000754	motif 2; other site
696747000755	active site
696747000756	motif 3; other site
696747000757	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
696747000758	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696747000759	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
696747000760	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
696747000761	active site
696747000762	metal binding site [ion binding]; metal-binding site
696747000763	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
696747000764	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
696747000765	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
696747000766	trimer interface [polypeptide binding]; other site
696747000767	putative metal binding site [ion binding]; other site
696747000768	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
696747000769	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
696747000770	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
696747000771	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
696747000772	TPR repeat; Region: TPR_11; pfam13414
696747000773	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000774	binding surface
696747000775	TPR motif; other site
696747000776	TPR repeat; Region: TPR_11; pfam13414
696747000777	Tetratricopeptide repeat; Region: TPR_1; pfam00515
696747000778	TPR repeat; Region: TPR_11; pfam13414
696747000779	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000780	binding surface
696747000781	TPR motif; other site
696747000782	TPR repeat; Region: TPR_11; pfam13414
696747000783	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747000784	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000785	binding surface
696747000786	TPR motif; other site
696747000787	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747000788	binding surface
696747000789	TPR motif; other site
696747000790	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
696747000791	Photosystem I protein M (PsaM); Region: PsaM; pfam07465
696747000792	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
696747000793	active site
696747000794	multimer interface [polypeptide binding]; other site
696747000795	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
696747000796	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747000797	dimer interface [polypeptide binding]; other site
696747000798	conserved gate region; other site
696747000799	putative PBP binding loops; other site
696747000800	ABC-ATPase subunit interface; other site
696747000801	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747000802	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
696747000803	Walker A/P-loop; other site
696747000804	ATP binding site [chemical binding]; other site
696747000805	Q-loop/lid; other site
696747000806	ABC transporter signature motif; other site
696747000807	Walker B; other site
696747000808	D-loop; other site
696747000809	H-loop/switch region; other site
696747000810	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
696747000811	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747000812	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747000813	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747000814	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
696747000815	cyclase homology domain; Region: CHD; cd07302
696747000816	nucleotidyl binding site; other site
696747000817	metal binding site [ion binding]; metal-binding site
696747000818	dimer interface [polypeptide binding]; other site
696747000819	Response regulator receiver domain; Region: Response_reg; pfam00072
696747000820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747000821	active site
696747000822	phosphorylation site [posttranslational modification]
696747000823	intermolecular recognition site; other site
696747000824	dimerization interface [polypeptide binding]; other site
696747000825	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747000826	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747000827	metal binding site [ion binding]; metal-binding site
696747000828	active site
696747000829	I-site; other site
696747000830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
696747000831	Response regulator receiver domain; Region: Response_reg; pfam00072
696747000832	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747000833	active site
696747000834	phosphorylation site [posttranslational modification]
696747000835	intermolecular recognition site; other site
696747000836	dimerization interface [polypeptide binding]; other site
696747000837	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747000838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747000839	active site
696747000840	phosphorylation site [posttranslational modification]
696747000841	intermolecular recognition site; other site
696747000842	dimerization interface [polypeptide binding]; other site
696747000843	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
696747000844	PAS domain S-box; Region: sensory_box; TIGR00229
696747000845	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747000846	putative active site [active]
696747000847	heme pocket [chemical binding]; other site
696747000848	PAS domain S-box; Region: sensory_box; TIGR00229
696747000849	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747000850	putative active site [active]
696747000851	heme pocket [chemical binding]; other site
696747000852	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747000853	GAF domain; Region: GAF; pfam01590
696747000854	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747000855	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747000856	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747000857	dimer interface [polypeptide binding]; other site
696747000858	phosphorylation site [posttranslational modification]
696747000859	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
696747000860	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747000861	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747000862	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747000863	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
696747000864	dimer interface [polypeptide binding]; other site
696747000865	phosphorylation site [posttranslational modification]
696747000866	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747000867	ATP binding site [chemical binding]; other site
696747000868	Mg2+ binding site [ion binding]; other site
696747000869	G-X-G motif; other site
696747000870	glycogen synthase; Provisional; Region: glgA; PRK00654
696747000871	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
696747000872	ADP-binding pocket [chemical binding]; other site
696747000873	homodimer interface [polypeptide binding]; other site
696747000874	sulfotransferase; Region: PLN02164
696747000875	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696747000876	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747000877	ligand binding site [chemical binding]; other site
696747000878	flexible hinge region; other site
696747000879	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747000880	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747000881	dimer interface [polypeptide binding]; other site
696747000882	phosphorylation site [posttranslational modification]
696747000883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747000884	ATP binding site [chemical binding]; other site
696747000885	Mg2+ binding site [ion binding]; other site
696747000886	G-X-G motif; other site
696747000887	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
696747000888	NADH(P)-binding; Region: NAD_binding_10; pfam13460
696747000889	NAD(P) binding site [chemical binding]; other site
696747000890	putative active site [active]
696747000891	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
696747000892	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
696747000893	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
696747000894	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
696747000895	active site
696747000896	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
696747000897	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
696747000898	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
696747000899	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
696747000900	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
696747000901	catalytic triad [active]
696747000902	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
696747000903	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
696747000904	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747000905	FeS/SAM binding site; other site
696747000906	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
696747000907	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
696747000908	intersubunit interface [polypeptide binding]; other site
696747000909	active site
696747000910	catalytic residue [active]
696747000911	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
696747000912	Recombination protein O N terminal; Region: RecO_N; pfam11967
696747000913	Recombination protein O C terminal; Region: RecO_C; pfam02565
696747000914	HindVP restriction endonuclease; Region: RE_HindVP; pfam09519
696747000915	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747000916	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
696747000917	cofactor binding site; other site
696747000918	DNA binding site [nucleotide binding]
696747000919	substrate interaction site [chemical binding]; other site
696747000920	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
696747000921	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
696747000922	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
696747000923	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
696747000924	glycine dehydrogenase; Provisional; Region: PRK05367
696747000925	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
696747000926	tetramer interface [polypeptide binding]; other site
696747000927	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747000928	catalytic residue [active]
696747000929	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
696747000930	tetramer interface [polypeptide binding]; other site
696747000931	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747000932	catalytic residue [active]
696747000933	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
696747000934	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
696747000935	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
696747000936	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
696747000937	L11 interface [polypeptide binding]; other site
696747000938	putative EF-Tu interaction site [polypeptide binding]; other site
696747000939	putative EF-G interaction site [polypeptide binding]; other site
696747000940	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
696747000941	23S rRNA interface [nucleotide binding]; other site
696747000942	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
696747000943	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
696747000944	mRNA/rRNA interface [nucleotide binding]; other site
696747000945	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
696747000946	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
696747000947	23S rRNA interface [nucleotide binding]; other site
696747000948	L7/L12 interface [polypeptide binding]; other site
696747000949	putative thiostrepton binding site; other site
696747000950	L25 interface [polypeptide binding]; other site
696747000951	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
696747000952	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
696747000953	putative homodimer interface [polypeptide binding]; other site
696747000954	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
696747000955	heterodimer interface [polypeptide binding]; other site
696747000956	homodimer interface [polypeptide binding]; other site
696747000957	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
696747000958	ribosomal protein L19; Region: rpl19; CHL00084
696747000959	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
696747000960	dimer interface [polypeptide binding]; other site
696747000961	motif 1; other site
696747000962	active site
696747000963	motif 2; other site
696747000964	motif 3; other site
696747000965	Predicted membrane protein [Function unknown]; Region: COG3463
696747000966	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
696747000967	adaptive-response sensory kinase; Validated; Region: PRK09303
696747000968	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
696747000969	tetramer interface [polypeptide binding]; other site
696747000970	dimer interface [polypeptide binding]; other site
696747000971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747000972	ATP binding site [chemical binding]; other site
696747000973	Mg2+ binding site [ion binding]; other site
696747000974	G-X-G motif; other site
696747000975	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747000976	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747000977	Probable transposase; Region: OrfB_IS605; pfam01385
696747000978	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747000979	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
696747000980	active site
696747000981	8-oxo-dGMP binding site [chemical binding]; other site
696747000982	nudix motif; other site
696747000983	metal binding site [ion binding]; metal-binding site
696747000984	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
696747000985	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
696747000986	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696747000987	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
696747000988	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696747000989	DNA binding residues [nucleotide binding]
696747000990	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
696747000991	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
696747000992	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
696747000993	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747000994	dimer interface [polypeptide binding]; other site
696747000995	conserved gate region; other site
696747000996	putative PBP binding loops; other site
696747000997	ABC-ATPase subunit interface; other site
696747000998	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
696747000999	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
696747001000	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747001001	dimer interface [polypeptide binding]; other site
696747001002	conserved gate region; other site
696747001003	putative PBP binding loops; other site
696747001004	ABC-ATPase subunit interface; other site
696747001005	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
696747001006	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747001007	Dynamin family; Region: Dynamin_N; pfam00350
696747001008	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747001009	putative active site [active]
696747001010	Protein of unknown function (DUF433); Region: DUF433; pfam04255
696747001011	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
696747001012	putative active site [active]
696747001013	CHAT domain; Region: CHAT; pfam12770
696747001014	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747001015	Probable transposase; Region: OrfB_IS605; pfam01385
696747001016	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747001017	FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764
696747001018	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001019	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001020	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747001021	binding surface
696747001022	TPR motif; other site
696747001023	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001024	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
696747001025	Fic/DOC family; Region: Fic; cl00960
696747001026	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
696747001027	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
696747001028	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
696747001029	catalytic core [active]
696747001030	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
696747001031	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
696747001032	homotetramer interface [polypeptide binding]; other site
696747001033	ligand binding site [chemical binding]; other site
696747001034	catalytic site [active]
696747001035	NAD binding site [chemical binding]; other site
696747001036	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
696747001037	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
696747001038	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
696747001039	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
696747001040	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
696747001041	active site
696747001042	dimer interface [polypeptide binding]; other site
696747001043	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696747001044	active site
696747001045	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
696747001046	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
696747001047	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747001048	FeS/SAM binding site; other site
696747001049	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
696747001050	Pyruvate formate lyase 1; Region: PFL1; cd01678
696747001051	coenzyme A binding site [chemical binding]; other site
696747001052	active site
696747001053	catalytic residues [active]
696747001054	glycine loop; other site
696747001055	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
696747001056	nucleotide binding site/active site [active]
696747001057	HIT family signature motif; other site
696747001058	catalytic residue [active]
696747001059	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696747001060	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696747001061	dimer interface [polypeptide binding]; other site
696747001062	putative CheW interface [polypeptide binding]; other site
696747001063	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
696747001064	active site
696747001065	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747001066	Probable transposase; Region: OrfB_IS605; pfam01385
696747001067	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747001068	Predicted transcriptional regulators [Transcription]; Region: COG1695
696747001069	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
696747001070	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
696747001071	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
696747001072	HlyD family secretion protein; Region: HlyD_3; pfam13437
696747001073	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
696747001074	Predicted membrane protein [Function unknown]; Region: COG2119
696747001075	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
696747001076	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
696747001077	4-alpha-glucanotransferase; Provisional; Region: PRK14508
696747001078	Helix-turn-helix domain; Region: HTH_25; pfam13413
696747001079	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
696747001080	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696747001081	RNA binding surface [nucleotide binding]; other site
696747001082	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
696747001083	active site
696747001084	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
696747001085	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
696747001086	phosphatidate cytidylyltransferase; Region: PLN02953
696747001087	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
696747001088	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747001089	S-adenosylmethionine binding site [chemical binding]; other site
696747001090	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
696747001091	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
696747001092	homodimer interface [polypeptide binding]; other site
696747001093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747001094	catalytic residue [active]
696747001095	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
696747001096	GTP-binding protein YchF; Reviewed; Region: PRK09601
696747001097	YchF GTPase; Region: YchF; cd01900
696747001098	G1 box; other site
696747001099	GTP/Mg2+ binding site [chemical binding]; other site
696747001100	Switch I region; other site
696747001101	G2 box; other site
696747001102	Switch II region; other site
696747001103	G3 box; other site
696747001104	G4 box; other site
696747001105	G5 box; other site
696747001106	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
696747001107	Predicted membrane protein [Function unknown]; Region: COG1950
696747001108	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
696747001109	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
696747001110	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747001111	Walker A motif; other site
696747001112	ATP binding site [chemical binding]; other site
696747001113	Walker B motif; other site
696747001114	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
696747001115	FtsH Extracellular; Region: FtsH_ext; pfam06480
696747001116	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
696747001117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747001118	Walker A motif; other site
696747001119	ATP binding site [chemical binding]; other site
696747001120	Walker B motif; other site
696747001121	arginine finger; other site
696747001122	Peptidase family M41; Region: Peptidase_M41; pfam01434
696747001123	Phosphate transporter family; Region: PHO4; pfam01384
696747001124	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
696747001125	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
696747001126	AAA ATPase domain; Region: AAA_16; pfam13191
696747001127	Walker A motif; other site
696747001128	ATP binding site [chemical binding]; other site
696747001129	Homeodomain-like domain; Region: HTH_23; pfam13384
696747001130	Winged helix-turn helix; Region: HTH_29; pfam13551
696747001131	Winged helix-turn helix; Region: HTH_33; pfam13592
696747001132	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696747001133	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747001134	ligand binding site [chemical binding]; other site
696747001135	flexible hinge region; other site
696747001136	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
696747001137	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
696747001138	putative active site [active]
696747001139	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696747001140	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747001141	Walker A/P-loop; other site
696747001142	ATP binding site [chemical binding]; other site
696747001143	Q-loop/lid; other site
696747001144	ABC transporter signature motif; other site
696747001145	Walker B; other site
696747001146	D-loop; other site
696747001147	H-loop/switch region; other site
696747001148	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
696747001149	HlyD family secretion protein; Region: HlyD_3; pfam13437
696747001150	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
696747001151	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
696747001152	Phosphotransferase enzyme family; Region: APH; pfam01636
696747001153	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
696747001154	substrate binding site [chemical binding]; other site
696747001155	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
696747001156	Protein of unknown function (DUF433); Region: DUF433; pfam04255
696747001157	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747001158	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747001159	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747001160	putative active site [active]
696747001161	putative NTP binding site [chemical binding]; other site
696747001162	putative nucleic acid binding site [nucleotide binding]; other site
696747001163	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747001164	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747001165	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747001166	active site
696747001167	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
696747001168	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747001169	putative active site [active]
696747001170	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
696747001171	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
696747001172	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
696747001173	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
696747001174	oligomeric interface; other site
696747001175	putative active site [active]
696747001176	homodimer interface [polypeptide binding]; other site
696747001177	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
696747001178	anti-sigma E factor; Provisional; Region: rseB; PRK09455
696747001179	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
696747001180	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696747001181	non-specific DNA binding site [nucleotide binding]; other site
696747001182	salt bridge; other site
696747001183	sequence-specific DNA binding site [nucleotide binding]; other site
696747001184	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
696747001185	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
696747001186	Protein of unknown function (DUF433); Region: DUF433; cl01030
696747001187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
696747001188	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
696747001189	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
696747001190	putative active site [active]
696747001191	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747001192	Walker A/P-loop; other site
696747001193	AAA domain; Region: AAA_21; pfam13304
696747001194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747001195	ATP binding site [chemical binding]; other site
696747001196	Mg2+ binding site [ion binding]; other site
696747001197	G-X-G motif; other site
696747001198	Beta-lactamase; Region: Beta-lactamase; pfam00144
696747001199	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
696747001200	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
696747001201	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
696747001202	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
696747001203	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
696747001204	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747001205	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747001206	active site
696747001207	ATP binding site [chemical binding]; other site
696747001208	substrate binding site [chemical binding]; other site
696747001209	activation loop (A-loop); other site
696747001210	GUN4-like; Region: GUN4; pfam05419
696747001211	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747001212	structural tetrad; other site
696747001213	PQQ-like domain; Region: PQQ_2; pfam13360
696747001214	glycogen branching enzyme; Provisional; Region: PRK05402
696747001215	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
696747001216	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
696747001217	active site
696747001218	catalytic site [active]
696747001219	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
696747001220	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
696747001221	active site
696747001222	DNA binding site [nucleotide binding]
696747001223	Int/Topo IB signature motif; other site
696747001224	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
696747001225	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747001226	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
696747001227	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
696747001228	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
696747001229	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
696747001230	L-aspartate oxidase; Provisional; Region: PRK07395
696747001231	L-aspartate oxidase; Provisional; Region: PRK06175
696747001232	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
696747001233	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
696747001234	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
696747001235	Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474
696747001236	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
696747001237	TPR repeat; Region: TPR_11; pfam13414
696747001238	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747001239	binding surface
696747001240	TPR motif; other site
696747001241	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001242	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747001243	TPR motif; other site
696747001244	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001245	binding surface
696747001246	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747001247	binding surface
696747001248	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001249	TPR motif; other site
696747001250	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747001251	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001252	binding surface
696747001253	TPR motif; other site
696747001254	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747001255	TPR motif; other site
696747001256	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001257	binding surface
696747001258	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747001260	binding surface
696747001261	TPR motif; other site
696747001262	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001263	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747001264	TPR motif; other site
696747001265	binding surface
696747001266	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001267	Tetratricopeptide repeat; Region: TPR_10; pfam13374
696747001268	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747001269	binding surface
696747001270	TPR motif; other site
696747001271	CHAT domain; Region: CHAT; pfam12770
696747001272	TIGR02594 family protein; Region: TIGR02594
696747001273	CHAP domain; Region: CHAP; cl17642
696747001274	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747001275	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747001276	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
696747001277	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
696747001278	oligomer interface [polypeptide binding]; other site
696747001279	metal binding site [ion binding]; metal-binding site
696747001280	metal binding site [ion binding]; metal-binding site
696747001281	Cl binding site [ion binding]; other site
696747001282	aspartate ring; other site
696747001283	basic sphincter; other site
696747001284	putative hydrophobic gate; other site
696747001285	periplasmic entrance; other site
696747001286	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747001287	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747001288	active site
696747001289	ATP binding site [chemical binding]; other site
696747001290	substrate binding site [chemical binding]; other site
696747001291	activation loop (A-loop); other site
696747001292	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747001293	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747001294	structural tetrad; other site
696747001295	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
696747001296	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747001297	dimerization interface [polypeptide binding]; other site
696747001298	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747001299	dimer interface [polypeptide binding]; other site
696747001300	phosphorylation site [posttranslational modification]
696747001301	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747001302	ATP binding site [chemical binding]; other site
696747001303	Mg2+ binding site [ion binding]; other site
696747001304	G-X-G motif; other site
696747001305	Uncharacterized conserved protein [Function unknown]; Region: COG1543
696747001306	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
696747001307	active site
696747001308	substrate binding site [chemical binding]; other site
696747001309	catalytic site [active]
696747001310	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
696747001311	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
696747001312	heterotetramer interface [polypeptide binding]; other site
696747001313	active site pocket [active]
696747001314	cleavage site
696747001315	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747001316	putative active site [active]
696747001317	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747001318	putative active site [active]
696747001319	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747001320	putative active site [active]
696747001321	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001322	active site
696747001323	dimerization interface [polypeptide binding]; other site
696747001324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001325	active site
696747001326	phosphorylation site [posttranslational modification]
696747001327	intermolecular recognition site; other site
696747001328	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747001329	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747001330	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747001331	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747001332	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747001333	putative active site [active]
696747001334	putative nucleic acid binding site [nucleotide binding]; other site
696747001335	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747001336	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747001337	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747001338	active site
696747001339	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
696747001340	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
696747001341	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
696747001342	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
696747001343	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
696747001344	active site
696747001345	ATP binding site [chemical binding]; other site
696747001346	substrate binding site [chemical binding]; other site
696747001347	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
696747001348	activation loop (A-loop); other site
696747001349	GUN4-like; Region: GUN4; pfam05419
696747001350	light-harvesting-like protein 3; Provisional; Region: PLN00014
696747001351	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
696747001352	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
696747001353	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
696747001354	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
696747001355	Domain of unknown function (DUF309); Region: DUF309; pfam03745
696747001356	ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165
696747001357	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747001358	ligand binding site [chemical binding]; other site
696747001359	flexible hinge region; other site
696747001360	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
696747001361	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
696747001362	catalytic residues [active]
696747001363	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
696747001364	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
696747001365	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747001366	TPR motif; other site
696747001367	binding surface
696747001368	CHAT domain; Region: CHAT; pfam12770
696747001369	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
696747001370	putative active site [active]
696747001371	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
696747001372	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696747001373	AAA ATPase domain; Region: AAA_16; pfam13191
696747001374	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
696747001375	Walker A motif; other site
696747001376	CHAT domain; Region: CHAT; cl17868
696747001377	CHAT domain; Region: CHAT; cl17868
696747001378	CHAT domain; Region: CHAT; pfam12770
696747001379	Catalytic GIY-YIG domain of type II restriction enzyme R.Eco29kI, R.NgoMIII, and similar proteins; Region: GIY-YIG_RE_Eco29kI_NgoMIII; cd10452
696747001380	homodimer interface [polypeptide binding]; other site
696747001381	GIY-YIG motif/motif A; other site
696747001382	active site
696747001383	DNA binding site [nucleotide binding]
696747001384	putative metal binding site [ion binding]; other site
696747001385	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
696747001386	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747001387	cofactor binding site; other site
696747001388	DNA binding site [nucleotide binding]
696747001389	substrate interaction site [chemical binding]; other site
696747001390	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747001391	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
696747001392	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
696747001393	putative Mg++ binding site [ion binding]; other site
696747001394	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
696747001395	Transposase IS200 like; Region: Y1_Tnp; cl00848
696747001396	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
696747001397	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
696747001398	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
696747001399	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
696747001400	DEAD/DEAH box helicase; Region: DEAD; pfam00270
696747001401	putative Mg++ binding site [ion binding]; other site
696747001402	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747001403	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747001404	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747001405	putative NTP binding site [chemical binding]; other site
696747001406	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747001407	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747001408	putative active site [active]
696747001409	putative nucleic acid binding site [nucleotide binding]; other site
696747001410	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747001411	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747001412	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747001413	active site
696747001414	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747001415	ATP-binding site [chemical binding]; other site
696747001416	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
696747001417	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
696747001418	FOG: CBS domain [General function prediction only]; Region: COG0517
696747001419	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747001420	FOG: CBS domain [General function prediction only]; Region: COG0517
696747001421	FOG: CBS domain [General function prediction only]; Region: COG0517
696747001422	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747001423	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747001424	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747001425	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747001426	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747001427	dimer interface [polypeptide binding]; other site
696747001428	phosphorylation site [posttranslational modification]
696747001429	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747001430	ATP binding site [chemical binding]; other site
696747001431	Mg2+ binding site [ion binding]; other site
696747001432	G-X-G motif; other site
696747001433	Cupin domain; Region: Cupin_2; cl17218
696747001434	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
696747001435	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
696747001436	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
696747001437	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
696747001438	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
696747001439	P-loop; other site
696747001440	Magnesium ion binding site [ion binding]; other site
696747001441	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
696747001442	dimerization interface [polypeptide binding]; other site
696747001443	cytochrome c biogenesis protein; Region: ccsA; CHL00045
696747001444	KGK domain; Region: KGK; pfam08872
696747001445	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
696747001446	Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498
696747001447	active site
696747001448	catalytic triad [active]
696747001449	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
696747001450	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
696747001451	BolA-like protein; Region: BolA; pfam01722
696747001452	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
696747001453	putative GSH binding site [chemical binding]; other site
696747001454	catalytic residues [active]
696747001455	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696747001456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001457	active site
696747001458	phosphorylation site [posttranslational modification]
696747001459	intermolecular recognition site; other site
696747001460	dimerization interface [polypeptide binding]; other site
696747001461	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747001462	DNA binding site [nucleotide binding]
696747001463	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
696747001464	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
696747001465	NAD(P) binding site [chemical binding]; other site
696747001466	catalytic residues [active]
696747001467	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
696747001468	SPFH domain / Band 7 family; Region: Band_7; pfam01145
696747001469	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
696747001470	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
696747001471	Surface antigen; Region: Bac_surface_Ag; pfam01103
696747001472	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747001473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001474	active site
696747001475	phosphorylation site [posttranslational modification]
696747001476	intermolecular recognition site; other site
696747001477	dimerization interface [polypeptide binding]; other site
696747001478	Response regulator receiver domain; Region: Response_reg; pfam00072
696747001479	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001480	active site
696747001481	phosphorylation site [posttranslational modification]
696747001482	intermolecular recognition site; other site
696747001483	dimerization interface [polypeptide binding]; other site
696747001484	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747001485	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747001486	putative active site [active]
696747001487	heme pocket [chemical binding]; other site
696747001488	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747001489	putative active site [active]
696747001490	heme pocket [chemical binding]; other site
696747001491	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747001492	PAS fold; Region: PAS_3; pfam08447
696747001493	putative active site [active]
696747001494	heme pocket [chemical binding]; other site
696747001495	PAS fold; Region: PAS_4; pfam08448
696747001496	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747001497	putative active site [active]
696747001498	heme pocket [chemical binding]; other site
696747001499	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
696747001500	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747001501	putative active site [active]
696747001502	heme pocket [chemical binding]; other site
696747001503	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747001504	dimer interface [polypeptide binding]; other site
696747001505	phosphorylation site [posttranslational modification]
696747001506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747001507	ATP binding site [chemical binding]; other site
696747001508	Mg2+ binding site [ion binding]; other site
696747001509	G-X-G motif; other site
696747001510	NADH dehydrogenase subunit 5; Region: ndhF; CHL00025
696747001511	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
696747001512	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
696747001513	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
696747001514	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
696747001515	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696747001516	NAD binding site [chemical binding]; other site
696747001517	substrate binding site [chemical binding]; other site
696747001518	active site
696747001519	GUN4-like; Region: GUN4; pfam05419
696747001520	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
696747001521	MoaE interaction surface [polypeptide binding]; other site
696747001522	MoeB interaction surface [polypeptide binding]; other site
696747001523	thiocarboxylated glycine; other site
696747001524	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
696747001525	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696747001526	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
696747001527	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696747001528	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
696747001529	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696747001530	Ligand Binding Site [chemical binding]; other site
696747001531	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
696747001532	UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186
696747001533	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
696747001534	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
696747001535	homodimer interface [polypeptide binding]; other site
696747001536	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747001537	catalytic residue [active]
696747001538	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
696747001539	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
696747001540	putative di-iron ligands [ion binding]; other site
696747001541	FAD binding domain; Region: FAD_binding_4; pfam01565
696747001542	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
696747001543	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
696747001544	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
696747001545	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
696747001546	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
696747001547	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
696747001548	TIGR02646 family protein; Region: TIGR02646
696747001549	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747001550	AAA domain; Region: AAA_21; pfam13304
696747001551	Walker A/P-loop; other site
696747001552	ATP binding site [chemical binding]; other site
696747001553	Ultra-violet resistance protein B; Region: UvrB; pfam12344
696747001554	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747001555	ABC transporter signature motif; other site
696747001556	Walker B; other site
696747001557	D-loop; other site
696747001558	H-loop/switch region; other site
696747001559	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
696747001560	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
696747001561	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
696747001562	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
696747001563	HsdM N-terminal domain; Region: HsdM_N; pfam12161
696747001564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747001565	S-adenosylmethionine binding site [chemical binding]; other site
696747001566	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747001567	active site
696747001568	S-layer homology domain; Region: SLH; pfam00395
696747001569	S-layer homology domain; Region: SLH; pfam00395
696747001570	S-layer homology domain; Region: SLH; pfam00395
696747001571	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
696747001572	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747001573	Circadian oscillating protein COP23; Region: COP23; pfam14218
696747001574	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696747001575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001576	active site
696747001577	phosphorylation site [posttranslational modification]
696747001578	intermolecular recognition site; other site
696747001579	dimerization interface [polypeptide binding]; other site
696747001580	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747001581	DNA binding site [nucleotide binding]
696747001582	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
696747001583	putative binding surface; other site
696747001584	active site
696747001585	Response regulator receiver domain; Region: Response_reg; pfam00072
696747001586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001587	active site
696747001588	phosphorylation site [posttranslational modification]
696747001589	intermolecular recognition site; other site
696747001590	dimerization interface [polypeptide binding]; other site
696747001591	Response regulator receiver domain; Region: Response_reg; pfam00072
696747001592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001593	active site
696747001594	phosphorylation site [posttranslational modification]
696747001595	intermolecular recognition site; other site
696747001596	dimerization interface [polypeptide binding]; other site
696747001597	Caspase domain; Region: Peptidase_C14; pfam00656
696747001598	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
696747001599	ATP-sulfurylase; Region: ATPS; cd00517
696747001600	active site
696747001601	HXXH motif; other site
696747001602	flexible loop; other site
696747001603	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747001604	Switch II region; other site
696747001605	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747001606	PAS fold; Region: PAS_7; pfam12860
696747001607	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747001608	GAF domain; Region: GAF_3; pfam13492
696747001609	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747001610	dimer interface [polypeptide binding]; other site
696747001611	phosphorylation site [posttranslational modification]
696747001612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747001613	ATP binding site [chemical binding]; other site
696747001614	Mg2+ binding site [ion binding]; other site
696747001615	G-X-G motif; other site
696747001616	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747001617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001618	active site
696747001619	phosphorylation site [posttranslational modification]
696747001620	intermolecular recognition site; other site
696747001621	dimerization interface [polypeptide binding]; other site
696747001622	Response regulator receiver domain; Region: Response_reg; pfam00072
696747001623	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001624	active site
696747001625	phosphorylation site [posttranslational modification]
696747001626	intermolecular recognition site; other site
696747001627	dimerization interface [polypeptide binding]; other site
696747001628	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747001629	cyclase homology domain; Region: CHD; cd07302
696747001630	nucleotidyl binding site; other site
696747001631	metal binding site [ion binding]; metal-binding site
696747001632	dimer interface [polypeptide binding]; other site
696747001633	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
696747001634	Uncharacterized conserved protein [Function unknown]; Region: COG5607
696747001635	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747001636	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747001637	metal binding site [ion binding]; metal-binding site
696747001638	active site
696747001639	I-site; other site
696747001640	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747001641	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747001642	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747001643	putative active site [active]
696747001644	heme pocket [chemical binding]; other site
696747001645	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
696747001646	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747001647	putative active site [active]
696747001648	heme pocket [chemical binding]; other site
696747001649	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747001650	dimer interface [polypeptide binding]; other site
696747001651	phosphorylation site [posttranslational modification]
696747001652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747001653	ATP binding site [chemical binding]; other site
696747001654	Mg2+ binding site [ion binding]; other site
696747001655	G-X-G motif; other site
696747001656	HEAT repeats; Region: HEAT_2; pfam13646
696747001657	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747001658	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747001659	active site
696747001660	ATP binding site [chemical binding]; other site
696747001661	substrate binding site [chemical binding]; other site
696747001662	activation loop (A-loop); other site
696747001663	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001664	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747001665	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747001666	PAS domain S-box; Region: sensory_box; TIGR00229
696747001667	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747001668	putative active site [active]
696747001669	heme pocket [chemical binding]; other site
696747001670	cyclase homology domain; Region: CHD; cd07302
696747001671	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747001672	nucleotidyl binding site; other site
696747001673	metal binding site [ion binding]; metal-binding site
696747001674	dimer interface [polypeptide binding]; other site
696747001675	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
696747001676	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
696747001677	putative metal binding site [ion binding]; other site
696747001678	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
696747001679	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
696747001680	putative metal binding site [ion binding]; other site
696747001681	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
696747001682	active site
696747001683	catalytic residues [active]
696747001684	metal binding site [ion binding]; metal-binding site
696747001685	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
696747001686	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747001687	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
696747001688	protein binding site [polypeptide binding]; other site
696747001689	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
696747001690	DnaA N-terminal domain; Region: DnaA_N; pfam11638
696747001691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747001692	Walker A motif; other site
696747001693	ATP binding site [chemical binding]; other site
696747001694	Walker B motif; other site
696747001695	arginine finger; other site
696747001696	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
696747001697	DnaA box-binding interface [nucleotide binding]; other site
696747001698	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
696747001699	PLD-like domain; Region: PLDc_2; pfam13091
696747001700	putative homodimer interface [polypeptide binding]; other site
696747001701	putative active site [active]
696747001702	catalytic site [active]
696747001703	DEAD-like helicases superfamily; Region: DEXDc; smart00487
696747001704	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747001705	ATP binding site [chemical binding]; other site
696747001706	putative Mg++ binding site [ion binding]; other site
696747001707	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747001708	nucleotide binding region [chemical binding]; other site
696747001709	ATP-binding site [chemical binding]; other site
696747001710	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
696747001711	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
696747001712	DNA polymerase III subunit beta; Validated; Region: PRK05643
696747001713	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
696747001714	putative DNA binding surface [nucleotide binding]; other site
696747001715	dimer interface [polypeptide binding]; other site
696747001716	beta-clamp/clamp loader binding surface; other site
696747001717	beta-clamp/translesion DNA polymerase binding surface; other site
696747001718	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
696747001719	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
696747001720	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747001721	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747001722	Probable transposase; Region: OrfB_IS605; pfam01385
696747001723	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747001724	ferredoxin-sulfite reductase; Region: sir; TIGR02042
696747001725	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
696747001726	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
696747001727	RNA methyltransferase, RsmE family; Region: TIGR00046
696747001728	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
696747001729	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
696747001730	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
696747001731	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
696747001732	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
696747001733	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747001734	binding surface
696747001735	TPR motif; other site
696747001736	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
696747001737	ATP-grasp domain; Region: ATP-grasp; pfam02222
696747001738	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747001739	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696747001740	active site
696747001741	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
696747001742	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
696747001743	Mg++ binding site [ion binding]; other site
696747001744	putative catalytic motif [active]
696747001745	putative substrate binding site [chemical binding]; other site
696747001746	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
696747001747	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
696747001748	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
696747001749	Walker A/P-loop; other site
696747001750	ATP binding site [chemical binding]; other site
696747001751	Q-loop/lid; other site
696747001752	ABC transporter signature motif; other site
696747001753	Walker B; other site
696747001754	D-loop; other site
696747001755	H-loop/switch region; other site
696747001756	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747001757	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
696747001758	NAD(P) binding site [chemical binding]; other site
696747001759	active site
696747001760	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
696747001761	substrate binding site [chemical binding]; other site
696747001762	active site
696747001763	GUN4-like; Region: GUN4; pfam05419
696747001764	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
696747001765	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
696747001766	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696747001767	catalytic residue [active]
696747001768	NifU-like domain; Region: NifU; pfam01106
696747001769	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696747001770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001771	active site
696747001772	phosphorylation site [posttranslational modification]
696747001773	intermolecular recognition site; other site
696747001774	dimerization interface [polypeptide binding]; other site
696747001775	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747001776	DNA binding site [nucleotide binding]
696747001777	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
696747001778	putative binding surface; other site
696747001779	active site
696747001780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001781	active site
696747001782	dimerization interface [polypeptide binding]; other site
696747001783	Response regulator receiver domain; Region: Response_reg; pfam00072
696747001784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001785	active site
696747001786	phosphorylation site [posttranslational modification]
696747001787	intermolecular recognition site; other site
696747001788	dimerization interface [polypeptide binding]; other site
696747001789	PAS domain; Region: PAS; smart00091
696747001790	PAS fold; Region: PAS_4; pfam08448
696747001791	PAS domain S-box; Region: sensory_box; TIGR00229
696747001792	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747001793	putative active site [active]
696747001794	heme pocket [chemical binding]; other site
696747001795	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
696747001796	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747001797	putative active site [active]
696747001798	heme pocket [chemical binding]; other site
696747001799	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747001800	dimer interface [polypeptide binding]; other site
696747001801	phosphorylation site [posttranslational modification]
696747001802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747001803	ATP binding site [chemical binding]; other site
696747001804	Mg2+ binding site [ion binding]; other site
696747001805	G-X-G motif; other site
696747001806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001807	active site
696747001808	phosphorylation site [posttranslational modification]
696747001809	intermolecular recognition site; other site
696747001810	dimerization interface [polypeptide binding]; other site
696747001811	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747001812	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747001813	metal binding site [ion binding]; metal-binding site
696747001814	active site
696747001815	I-site; other site
696747001816	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
696747001817	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
696747001818	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
696747001819	THF binding site; other site
696747001820	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
696747001821	substrate binding site [chemical binding]; other site
696747001822	THF binding site; other site
696747001823	zinc-binding site [ion binding]; other site
696747001824	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
696747001825	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
696747001826	putative di-iron ligands [ion binding]; other site
696747001827	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
696747001828	Cytochrome C' Region: Cytochrom_C_2; pfam01322
696747001829	tocopherol O-methyltransferase; Region: PLN02244
696747001830	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747001831	S-adenosylmethionine binding site [chemical binding]; other site
696747001832	DsrE/DsrF-like family; Region: DrsE; pfam02635
696747001833	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
696747001834	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
696747001835	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
696747001836	active site
696747001837	dimer interface [polypeptide binding]; other site
696747001838	motif 1; other site
696747001839	motif 2; other site
696747001840	motif 3; other site
696747001841	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
696747001842	anticodon binding site; other site
696747001843	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747001844	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747001845	NTP binding site [chemical binding]; other site
696747001846	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747001847	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747001848	putative active site [active]
696747001849	putative nucleic acid binding site [nucleotide binding]; other site
696747001850	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747001851	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747001852	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747001853	active site
696747001854	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747001855	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747001856	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747001857	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747001858	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747001859	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747001860	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747001861	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747001862	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
696747001863	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
696747001864	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747001865	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747001866	dimer interface [polypeptide binding]; other site
696747001867	phosphorylation site [posttranslational modification]
696747001868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747001869	ATP binding site [chemical binding]; other site
696747001870	Mg2+ binding site [ion binding]; other site
696747001871	G-X-G motif; other site
696747001872	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696747001873	active site
696747001874	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
696747001875	C-terminal peptidase (prc); Region: prc; TIGR00225
696747001876	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
696747001877	protein binding site [polypeptide binding]; other site
696747001878	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
696747001879	Catalytic dyad [active]
696747001880	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
696747001881	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
696747001882	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
696747001883	Esterase/lipase [General function prediction only]; Region: COG1647
696747001884	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747001885	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747001886	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747001887	Rapsyn N-terminal myristoylation and linker region; Region: Rapsyn_N; pfam10579
696747001888	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747001889	binding surface
696747001890	TPR motif; other site
696747001891	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747001892	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747001893	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747001894	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747001895	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747001896	Cytochrome Cytochrome b558 alpha-subunit; Region: Cytochrom_B558a; pfam05038
696747001897	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
696747001898	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
696747001899	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
696747001900	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
696747001901	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
696747001902	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
696747001903	active site
696747001904	dimer interface [polypeptide binding]; other site
696747001905	catalytic nucleophile [active]
696747001906	Response regulator receiver domain; Region: Response_reg; pfam00072
696747001907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001908	active site
696747001909	phosphorylation site [posttranslational modification]
696747001910	intermolecular recognition site; other site
696747001911	dimerization interface [polypeptide binding]; other site
696747001912	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
696747001913	putative binding surface; other site
696747001914	active site
696747001915	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
696747001916	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
696747001917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747001918	ATP binding site [chemical binding]; other site
696747001919	Mg2+ binding site [ion binding]; other site
696747001920	G-X-G motif; other site
696747001921	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
696747001922	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
696747001923	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
696747001924	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696747001925	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696747001926	dimer interface [polypeptide binding]; other site
696747001927	putative CheW interface [polypeptide binding]; other site
696747001928	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696747001929	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696747001930	dimer interface [polypeptide binding]; other site
696747001931	HEAT repeats; Region: HEAT_2; pfam13646
696747001932	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
696747001933	HEAT repeats; Region: HEAT_2; pfam13646
696747001934	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
696747001935	protein binding surface [polypeptide binding]; other site
696747001936	HEAT repeats; Region: HEAT_2; pfam13646
696747001937	HEAT repeats; Region: HEAT_2; pfam13646
696747001938	HEAT repeats; Region: HEAT_2; pfam13646
696747001939	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
696747001940	protein binding surface [polypeptide binding]; other site
696747001941	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
696747001942	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
696747001943	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
696747001944	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
696747001945	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
696747001946	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747001947	active site
696747001948	phosphorylation site [posttranslational modification]
696747001949	intermolecular recognition site; other site
696747001950	dimerization interface [polypeptide binding]; other site
696747001951	CheB methylesterase; Region: CheB_methylest; pfam01339
696747001952	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
696747001953	Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194
696747001954	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
696747001955	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
696747001956	ResB-like family; Region: ResB; pfam05140
696747001957	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
696747001958	Putative outer membrane protein; Region: HP_OMP_2; pfam02521
696747001959	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
696747001960	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
696747001961	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
696747001962	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
696747001963	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
696747001964	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
696747001965	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747001966	FeS/SAM binding site; other site
696747001967	Uncharacterized conserved protein [Function unknown]; Region: COG4095
696747001968	PsbJ; Region: PsbJ; cl09469
696747001969	photosystem II reaction center L; Provisional; Region: psbL; PRK00753
696747001970	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
696747001971	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
696747001972	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
696747001973	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
696747001974	Ycf48-like protein; Provisional; Region: PRK13684
696747001975	Rubredoxin; Region: Rubredoxin; pfam00301
696747001976	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
696747001977	iron binding site [ion binding]; other site
696747001978	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
696747001979	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
696747001980	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
696747001981	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
696747001982	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
696747001983	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
696747001984	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
696747001985	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
696747001986	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
696747001987	dimerization interface [polypeptide binding]; other site
696747001988	ATP binding site [chemical binding]; other site
696747001989	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
696747001990	dimerization interface [polypeptide binding]; other site
696747001991	ATP binding site [chemical binding]; other site
696747001992	amidophosphoribosyltransferase; Provisional; Region: PRK07349
696747001993	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
696747001994	active site
696747001995	tetramer interface [polypeptide binding]; other site
696747001996	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696747001997	active site
696747001998	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
696747001999	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
696747002000	putative active site [active]
696747002001	catalytic triad [active]
696747002002	putative dimer interface [polypeptide binding]; other site
696747002003	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
696747002004	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696747002005	Walker A motif; other site
696747002006	ATP binding site [chemical binding]; other site
696747002007	Walker B motif; other site
696747002008	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
696747002009	tetramer interface [polypeptide binding]; other site
696747002010	dimer interface [polypeptide binding]; other site
696747002011	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
696747002012	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
696747002013	core domain interface [polypeptide binding]; other site
696747002014	delta subunit interface [polypeptide binding]; other site
696747002015	epsilon subunit interface [polypeptide binding]; other site
696747002016	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
696747002017	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
696747002018	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
696747002019	beta subunit interaction interface [polypeptide binding]; other site
696747002020	Walker A motif; other site
696747002021	ATP binding site [chemical binding]; other site
696747002022	Walker B motif; other site
696747002023	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
696747002024	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
696747002025	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
696747002026	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
696747002027	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
696747002028	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
696747002029	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
696747002030	ATP synthase CF0 C subunit; Region: atpH; CHL00061
696747002031	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
696747002032	ATP synthase CF0 A subunit; Region: atpI; CHL00046
696747002033	ATP synthase I chain; Region: ATP_synt_I; pfam03899
696747002034	prolyl-tRNA synthetase; Provisional; Region: PRK09194
696747002035	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
696747002036	dimer interface [polypeptide binding]; other site
696747002037	motif 1; other site
696747002038	active site
696747002039	motif 2; other site
696747002040	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
696747002041	putative deacylase active site [active]
696747002042	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
696747002043	active site
696747002044	motif 3; other site
696747002045	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
696747002046	anticodon binding site; other site
696747002047	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
696747002048	PLD-like domain; Region: PLDc_2; pfam13091
696747002049	putative active site [active]
696747002050	catalytic site [active]
696747002051	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
696747002052	PLD-like domain; Region: PLDc_2; pfam13091
696747002053	putative active site [active]
696747002054	catalytic site [active]
696747002055	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
696747002056	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
696747002057	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
696747002058	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
696747002059	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696747002060	catalytic residue [active]
696747002061	histidinol-phosphate aminotransferase; Provisional; Region: PRK02610
696747002062	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696747002063	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747002064	homodimer interface [polypeptide binding]; other site
696747002065	catalytic residue [active]
696747002066	NAD synthetase; Provisional; Region: PRK13981
696747002067	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
696747002068	multimer interface [polypeptide binding]; other site
696747002069	active site
696747002070	catalytic triad [active]
696747002071	protein interface 1 [polypeptide binding]; other site
696747002072	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
696747002073	homodimer interface [polypeptide binding]; other site
696747002074	NAD binding pocket [chemical binding]; other site
696747002075	ATP binding pocket [chemical binding]; other site
696747002076	Mg binding site [ion binding]; other site
696747002077	active-site loop [active]
696747002078	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
696747002079	putative active site [active]
696747002080	Protein of unknown function (DUF433); Region: DUF433; cl01030
696747002081	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
696747002082	oligomeric interface; other site
696747002083	putative active site [active]
696747002084	homodimer interface [polypeptide binding]; other site
696747002085	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
696747002086	oligomeric interface; other site
696747002087	putative active site [active]
696747002088	homodimer interface [polypeptide binding]; other site
696747002089	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747002090	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747002091	putative active site [active]
696747002092	putative nucleic acid binding site [nucleotide binding]; other site
696747002093	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747002094	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747002095	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747002096	active site
696747002097	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747002098	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747002099	putative NTP binding site [chemical binding]; other site
696747002100	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747002101	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002102	putative active site [active]
696747002103	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002104	putative active site [active]
696747002105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747002106	NACHT domain; Region: NACHT; pfam05729
696747002107	Walker A/P-loop; other site
696747002108	ATP binding site [chemical binding]; other site
696747002109	Q-loop/lid; other site
696747002110	Protein of unknown function (DUF433); Region: DUF433; cl01030
696747002111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
696747002112	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696747002113	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696747002114	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
696747002115	active site
696747002116	catalytic residues [active]
696747002117	DNA binding site [nucleotide binding]
696747002118	Int/Topo IB signature motif; other site
696747002119	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
696747002120	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747002121	G1 box; other site
696747002122	GTP/Mg2+ binding site [chemical binding]; other site
696747002123	G2 box; other site
696747002124	Switch I region; other site
696747002125	hypothetical protein; Provisional; Region: PRK09866
696747002126	PemK-like protein; Region: PemK; pfam02452
696747002127	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
696747002128	DNA methylase; Region: N6_N4_Mtase; pfam01555
696747002129	DNA methylase; Region: N6_N4_Mtase; pfam01555
696747002130	Restriction endonuclease NotI; Region: NotI; pfam12183
696747002131	PemK-like protein; Region: PemK; pfam02452
696747002132	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
696747002133	HsdM N-terminal domain; Region: HsdM_N; pfam12161
696747002134	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747002135	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747002136	putative active site [active]
696747002137	putative NTP binding site [chemical binding]; other site
696747002138	putative nucleic acid binding site [nucleotide binding]; other site
696747002139	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747002140	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747002141	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747002142	active site
696747002143	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747002144	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
696747002145	Phage tail repeat like; Region: PTR; pfam12789
696747002146	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747002147	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747002148	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747002149	putative active site [active]
696747002150	putative nucleic acid binding site [nucleotide binding]; other site
696747002151	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747002152	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747002153	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747002154	active site
696747002155	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747002156	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747002157	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747002158	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747002159	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
696747002160	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
696747002161	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696747002162	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
696747002163	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696747002164	DNA binding residues [nucleotide binding]
696747002165	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
696747002166	metal binding site 2 [ion binding]; metal-binding site
696747002167	putative DNA binding helix; other site
696747002168	metal binding site 1 [ion binding]; metal-binding site
696747002169	dimer interface [polypeptide binding]; other site
696747002170	structural Zn2+ binding site [ion binding]; other site
696747002171	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
696747002172	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747002173	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747002174	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
696747002175	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747002176	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747002177	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747002178	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
696747002179	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
696747002180	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
696747002181	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696747002182	catalytic loop [active]
696747002183	iron binding site [ion binding]; other site
696747002184	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
696747002185	Stage II sporulation protein; Region: SpoIID; pfam08486
696747002186	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
696747002187	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
696747002188	phosphoenolpyruvate synthase; Validated; Region: PRK06464
696747002189	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
696747002190	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
696747002191	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
696747002192	Predicted transcriptional regulators [Transcription]; Region: COG1733
696747002193	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696747002194	dimerization interface [polypeptide binding]; other site
696747002195	putative DNA binding site [nucleotide binding]; other site
696747002196	putative Zn2+ binding site [ion binding]; other site
696747002197	16S rRNA methyltransferase B; Provisional; Region: PRK14901
696747002198	NusB family; Region: NusB; pfam01029
696747002199	putative RNA binding site [nucleotide binding]; other site
696747002200	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747002201	S-adenosylmethionine binding site [chemical binding]; other site
696747002202	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
696747002203	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696747002204	non-specific DNA binding site [nucleotide binding]; other site
696747002205	salt bridge; other site
696747002206	sequence-specific DNA binding site [nucleotide binding]; other site
696747002207	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
696747002208	DHH family; Region: DHH; pfam01368
696747002209	FOG: CBS domain [General function prediction only]; Region: COG0517
696747002210	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
696747002211	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
696747002212	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
696747002213	active site
696747002214	NTP binding site [chemical binding]; other site
696747002215	metal binding triad [ion binding]; metal-binding site
696747002216	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
696747002217	serpin-like protein; Provisional; Region: PHA02660
696747002218	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172
696747002219	reactive center loop; other site
696747002220	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
696747002221	active site
696747002222	putative lithium-binding site [ion binding]; other site
696747002223	substrate binding site [chemical binding]; other site
696747002224	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002225	putative active site [active]
696747002226	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002227	putative active site [active]
696747002228	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002229	putative active site [active]
696747002230	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002231	putative active site [active]
696747002232	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002233	putative active site [active]
696747002234	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002235	putative active site [active]
696747002236	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002237	putative active site [active]
696747002238	Domain of unknown function DUF29; Region: DUF29; pfam01724
696747002239	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696747002240	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696747002241	active site
696747002242	Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493
696747002243	TPR repeat; Region: TPR_11; pfam13414
696747002244	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002245	binding surface
696747002246	TPR motif; other site
696747002247	TPR repeat; Region: TPR_11; pfam13414
696747002248	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002249	binding surface
696747002250	TPR motif; other site
696747002251	TPR repeat; Region: TPR_11; pfam13414
696747002252	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
696747002253	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
696747002254	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
696747002255	Methyltransferase domain; Region: Methyltransf_24; pfam13578
696747002256	Methyltransferase domain; Region: Methyltransf_24; pfam13578
696747002257	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
696747002258	Methyltransferase domain; Region: Methyltransf_24; pfam13578
696747002259	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747002260	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696747002261	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747002262	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002263	binding surface
696747002264	TPR motif; other site
696747002265	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002266	TPR motif; other site
696747002267	binding surface
696747002268	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002269	binding surface
696747002270	TPR motif; other site
696747002271	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002272	TPR motif; other site
696747002273	TPR repeat; Region: TPR_11; pfam13414
696747002274	binding surface
696747002275	TPR repeat; Region: TPR_11; pfam13414
696747002276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002277	binding surface
696747002278	TPR motif; other site
696747002279	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747002280	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002281	binding surface
696747002282	TPR motif; other site
696747002283	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
696747002284	TPR repeat; Region: TPR_11; pfam13414
696747002285	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002286	binding surface
696747002287	TPR motif; other site
696747002288	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747002289	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002290	binding surface
696747002291	TPR motif; other site
696747002292	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002293	binding surface
696747002294	TPR motif; other site
696747002295	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002296	binding surface
696747002297	TPR motif; other site
696747002298	Protein of unknown function (DUF563); Region: DUF563; pfam04577
696747002299	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002300	TPR motif; other site
696747002301	TPR repeat; Region: TPR_11; pfam13414
696747002302	binding surface
696747002303	TPR repeat; Region: TPR_11; pfam13414
696747002304	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002305	binding surface
696747002306	TPR motif; other site
696747002307	TPR repeat; Region: TPR_11; pfam13414
696747002308	TPR repeat; Region: TPR_11; pfam13414
696747002309	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002310	TPR motif; other site
696747002311	binding surface
696747002312	TPR repeat; Region: TPR_11; pfam13414
696747002313	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002314	binding surface
696747002315	TPR motif; other site
696747002316	Bacterial transcriptional activator domain; Region: BTAD; smart01043
696747002317	TPR repeat; Region: TPR_11; pfam13414
696747002318	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002319	binding surface
696747002320	TPR motif; other site
696747002321	TPR repeat; Region: TPR_11; pfam13414
696747002322	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747002323	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747002324	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747002325	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747002326	ABC-2 type transporter; Region: ABC2_membrane; cl17235
696747002327	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
696747002328	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696747002329	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747002330	Walker A/P-loop; other site
696747002331	ATP binding site [chemical binding]; other site
696747002332	Q-loop/lid; other site
696747002333	ABC transporter signature motif; other site
696747002334	Walker B; other site
696747002335	D-loop; other site
696747002336	H-loop/switch region; other site
696747002337	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696747002338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747002339	active site
696747002340	phosphorylation site [posttranslational modification]
696747002341	intermolecular recognition site; other site
696747002342	dimerization interface [polypeptide binding]; other site
696747002343	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747002344	DNA binding site [nucleotide binding]
696747002345	Uncharacterized conserved protein [Function unknown]; Region: COG3391
696747002346	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
696747002347	SdiA-regulated; Region: SdiA-regulated; cd09971
696747002348	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747002349	Uncharacterized conserved protein [Function unknown]; Region: COG3391
696747002350	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
696747002351	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
696747002352	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
696747002353	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
696747002354	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696747002355	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
696747002356	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
696747002357	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696747002358	active site
696747002359	metal binding site [ion binding]; metal-binding site
696747002360	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
696747002361	homodecamer interface [polypeptide binding]; other site
696747002362	GTP cyclohydrolase I; Provisional; Region: PLN03044
696747002363	active site
696747002364	putative catalytic site residues [active]
696747002365	zinc binding site [ion binding]; other site
696747002366	GTP-CH-I/GFRP interaction surface; other site
696747002367	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
696747002368	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
696747002369	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
696747002370	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
696747002371	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
696747002372	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
696747002373	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
696747002374	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
696747002375	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
696747002376	putative NAD(P) binding site [chemical binding]; other site
696747002377	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
696747002378	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
696747002379	E3 interaction surface; other site
696747002380	lipoyl attachment site [posttranslational modification]; other site
696747002381	e3 binding domain; Region: E3_binding; pfam02817
696747002382	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
696747002383	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
696747002384	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
696747002385	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
696747002386	acyl-activating enzyme (AAE) consensus motif; other site
696747002387	putative AMP binding site [chemical binding]; other site
696747002388	putative active site [active]
696747002389	putative CoA binding site [chemical binding]; other site
696747002390	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747002391	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747002392	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
696747002393	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
696747002394	Sulfate transporter family; Region: Sulfate_transp; pfam00916
696747002395	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
696747002396	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
696747002397	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
696747002398	Sulfate transporter family; Region: Sulfate_transp; pfam00916
696747002399	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
696747002400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747002401	putative PBP binding loops; other site
696747002402	dimer interface [polypeptide binding]; other site
696747002403	ABC-ATPase subunit interface; other site
696747002404	S-layer homology domain; Region: SLH; pfam00395
696747002405	S-layer homology domain; Region: SLH; pfam00395
696747002406	Dor1-like family; Region: Dor1; pfam04124
696747002407	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
696747002408	guanine deaminase; Provisional; Region: PRK09228
696747002409	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
696747002410	active site
696747002411	TM2 domain; Region: TM2; cl00984
696747002412	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
696747002413	diiron binding motif [ion binding]; other site
696747002414	hydrolase; Region: PLN02811
696747002415	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696747002416	motif II; other site
696747002417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747002418	S-adenosylmethionine binding site [chemical binding]; other site
696747002419	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
696747002420	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747002421	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
696747002422	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747002423	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747002424	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747002425	putative active site [active]
696747002426	putative NTP binding site [chemical binding]; other site
696747002427	putative nucleic acid binding site [nucleotide binding]; other site
696747002428	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747002429	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747002430	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747002431	active site
696747002432	Ycf35; Provisional; Region: ycf35; CHL00193
696747002433	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
696747002434	AAA ATPase domain; Region: AAA_16; pfam13191
696747002435	AAA domain; Region: AAA_22; pfam13401
696747002436	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
696747002437	tartrate dehydrogenase; Region: TTC; TIGR02089
696747002438	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696747002439	Ligand Binding Site [chemical binding]; other site
696747002440	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
696747002441	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
696747002442	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
696747002443	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
696747002444	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
696747002445	G1 box; other site
696747002446	putative GEF interaction site [polypeptide binding]; other site
696747002447	GTP/Mg2+ binding site [chemical binding]; other site
696747002448	Switch I region; other site
696747002449	G2 box; other site
696747002450	G3 box; other site
696747002451	Switch II region; other site
696747002452	G4 box; other site
696747002453	G5 box; other site
696747002454	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
696747002455	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
696747002456	quinolinate synthetase; Provisional; Region: PRK09375
696747002457	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
696747002458	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696747002459	putative active site [active]
696747002460	putative metal binding site [ion binding]; other site
696747002461	Photosystem II 12 kDa extrinsic protein (PsbU); Region: PsbU; pfam06514
696747002462	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
696747002463	putative hydrophobic ligand binding site [chemical binding]; other site
696747002464	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
696747002465	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696747002466	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
696747002467	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
696747002468	Low molecular weight phosphatase family; Region: LMWPc; cl00105
696747002469	active site
696747002470	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747002471	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747002472	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
696747002473	phosphoglyceromutase; Provisional; Region: PRK05434
696747002474	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
696747002475	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747002476	dimer interface [polypeptide binding]; other site
696747002477	conserved gate region; other site
696747002478	putative PBP binding loops; other site
696747002479	ABC-ATPase subunit interface; other site
696747002480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747002481	dimer interface [polypeptide binding]; other site
696747002482	conserved gate region; other site
696747002483	putative PBP binding loops; other site
696747002484	ABC-ATPase subunit interface; other site
696747002485	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
696747002486	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
696747002487	Protein of unknown function (DUF422); Region: DUF422; cl00991
696747002488	S-layer homology domain; Region: SLH; pfam00395
696747002489	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
696747002490	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
696747002491	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
696747002492	SmpB-tmRNA interface; other site
696747002493	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
696747002494	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002495	putative active site [active]
696747002496	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002497	putative active site [active]
696747002498	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002499	putative active site [active]
696747002500	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002501	putative active site [active]
696747002502	Domain of unknown function DUF29; Region: DUF29; pfam01724
696747002503	Protein of unknown function (DUF98); Region: DUF98; pfam01947
696747002504	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
696747002505	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
696747002506	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
696747002507	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
696747002508	active site
696747002509	tellurite resistance protein terB; Region: terB; cd07176
696747002510	putative metal binding site [ion binding]; other site
696747002511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747002512	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
696747002513	Walker A motif; other site
696747002514	ATP binding site [chemical binding]; other site
696747002515	Walker B motif; other site
696747002516	arginine finger; other site
696747002517	Transmembrane proteins 14C; Region: Tmemb_14; pfam03647
696747002518	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
696747002519	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
696747002520	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
696747002521	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696747002522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747002523	active site
696747002524	phosphorylation site [posttranslational modification]
696747002525	intermolecular recognition site; other site
696747002526	dimerization interface [polypeptide binding]; other site
696747002527	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747002528	DNA binding site [nucleotide binding]
696747002529	Response regulator receiver domain; Region: Response_reg; pfam00072
696747002530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747002531	active site
696747002532	phosphorylation site [posttranslational modification]
696747002533	intermolecular recognition site; other site
696747002534	dimerization interface [polypeptide binding]; other site
696747002535	Response regulator receiver domain; Region: Response_reg; pfam00072
696747002536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747002537	active site
696747002538	phosphorylation site [posttranslational modification]
696747002539	intermolecular recognition site; other site
696747002540	dimerization interface [polypeptide binding]; other site
696747002541	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747002542	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747002543	metal binding site [ion binding]; metal-binding site
696747002544	active site
696747002545	I-site; other site
696747002546	Response regulator receiver domain; Region: Response_reg; pfam00072
696747002547	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747002548	active site
696747002549	phosphorylation site [posttranslational modification]
696747002550	intermolecular recognition site; other site
696747002551	dimerization interface [polypeptide binding]; other site
696747002552	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
696747002553	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
696747002554	Cl- selectivity filter; other site
696747002555	Cl- binding residues [ion binding]; other site
696747002556	pore gating glutamate residue; other site
696747002557	dimer interface [polypeptide binding]; other site
696747002558	H+/Cl- coupling transport residue; other site
696747002559	FOG: CBS domain [General function prediction only]; Region: COG0517
696747002560	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
696747002561	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
696747002562	Ligand Binding Site [chemical binding]; other site
696747002563	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696747002564	Ligand Binding Site [chemical binding]; other site
696747002565	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
696747002566	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696747002567	Coenzyme A binding pocket [chemical binding]; other site
696747002568	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
696747002569	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
696747002570	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
696747002571	active site
696747002572	hypothetical protein; Validated; Region: PRK00153
696747002573	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
696747002574	FAD binding domain; Region: FAD_binding_4; pfam01565
696747002575	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
696747002576	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
696747002577	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
696747002578	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
696747002579	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
696747002580	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
696747002581	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
696747002582	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
696747002583	thiamine monophosphate kinase; Provisional; Region: PRK05731
696747002584	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
696747002585	ATP binding site [chemical binding]; other site
696747002586	dimerization interface [polypeptide binding]; other site
696747002587	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
696747002588	chorismate binding enzyme; Region: Chorismate_bind; cl10555
696747002589	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
696747002590	Cytochrome P450; Region: p450; cl12078
696747002591	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
696747002592	UbiA prenyltransferase family; Region: UbiA; pfam01040
696747002593	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
696747002594	HsdM N-terminal domain; Region: HsdM_N; pfam12161
696747002595	Methyltransferase domain; Region: Methyltransf_26; pfam13659
696747002596	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
696747002597	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
696747002598	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
696747002599	DNA methylase; Region: N6_N4_Mtase; cl17433
696747002600	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002601	putative active site [active]
696747002602	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002603	putative active site [active]
696747002604	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
696747002605	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
696747002606	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747002607	ATP binding site [chemical binding]; other site
696747002608	putative Mg++ binding site [ion binding]; other site
696747002609	Protein of unknown function DUF45; Region: DUF45; pfam01863
696747002610	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
696747002611	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
696747002612	S-layer homology domain; Region: SLH; pfam00395
696747002613	S-layer homology domain; Region: SLH; pfam00395
696747002614	RRXRR protein; Region: RRXRR; pfam14239
696747002615	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747002616	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747002617	Haemolytic domain; Region: Haemolytic; pfam01809
696747002618	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
696747002619	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
696747002620	RNA binding site [nucleotide binding]; other site
696747002621	active site
696747002622	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
696747002623	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747002624	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747002625	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696747002626	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
696747002627	Walker A/P-loop; other site
696747002628	ATP binding site [chemical binding]; other site
696747002629	Q-loop/lid; other site
696747002630	ABC transporter signature motif; other site
696747002631	Walker B; other site
696747002632	D-loop; other site
696747002633	H-loop/switch region; other site
696747002634	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
696747002635	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
696747002636	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
696747002637	putative acyl-acceptor binding pocket; other site
696747002638	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
696747002639	GSH binding site [chemical binding]; other site
696747002640	catalytic residues [active]
696747002641	glutathione synthetase; Provisional; Region: PRK05246
696747002642	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
696747002643	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
696747002644	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696747002645	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747002646	S-adenosylmethionine binding site [chemical binding]; other site
696747002647	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
696747002648	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
696747002649	putative valine binding site [chemical binding]; other site
696747002650	dimer interface [polypeptide binding]; other site
696747002651	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
696747002652	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
696747002653	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
696747002654	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
696747002655	nitrilase; Region: PLN02798
696747002656	putative active site [active]
696747002657	catalytic triad [active]
696747002658	dimer interface [polypeptide binding]; other site
696747002659	photosystem I reaction center subunit IX; Provisional; Region: PRK02733
696747002660	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
696747002661	UGMP family protein; Validated; Region: PRK09604
696747002662	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
696747002663	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
696747002664	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
696747002665	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747002666	FeS/SAM binding site; other site
696747002667	TRAM domain; Region: TRAM; pfam01938
696747002668	CAAX protease self-immunity; Region: Abi; pfam02517
696747002669	Response regulator receiver domain; Region: Response_reg; pfam00072
696747002670	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747002671	active site
696747002672	phosphorylation site [posttranslational modification]
696747002673	intermolecular recognition site; other site
696747002674	dimerization interface [polypeptide binding]; other site
696747002675	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747002676	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747002677	metal binding site [ion binding]; metal-binding site
696747002678	active site
696747002679	I-site; other site
696747002680	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747002681	PAS domain S-box; Region: sensory_box; TIGR00229
696747002682	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
696747002683	putative active site [active]
696747002684	heme pocket [chemical binding]; other site
696747002685	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747002686	PAS fold; Region: PAS_3; pfam08447
696747002687	putative active site [active]
696747002688	heme pocket [chemical binding]; other site
696747002689	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747002690	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747002691	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747002692	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747002693	dimer interface [polypeptide binding]; other site
696747002694	phosphorylation site [posttranslational modification]
696747002695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747002696	ATP binding site [chemical binding]; other site
696747002697	Mg2+ binding site [ion binding]; other site
696747002698	G-X-G motif; other site
696747002699	Response regulator receiver domain; Region: Response_reg; pfam00072
696747002700	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747002701	active site
696747002702	phosphorylation site [posttranslational modification]
696747002703	intermolecular recognition site; other site
696747002704	dimerization interface [polypeptide binding]; other site
696747002705	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
696747002706	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
696747002707	catalytic core [active]
696747002708	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
696747002709	catalytic core [active]
696747002710	dihydroorotase; Provisional; Region: PRK07369
696747002711	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
696747002712	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
696747002713	active site
696747002714	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
696747002715	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
696747002716	Catalytic site [active]
696747002717	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
696747002718	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
696747002719	putative NAD(P) binding site [chemical binding]; other site
696747002720	active site
696747002721	transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634
696747002722	putative RNA binding site [nucleotide binding]; other site
696747002723	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
696747002724	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
696747002725	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
696747002726	P loop; other site
696747002727	GTP binding site [chemical binding]; other site
696747002728	GAF domain; Region: GAF_3; pfam13492
696747002729	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
696747002730	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
696747002731	argininosuccinate lyase; Provisional; Region: PRK00855
696747002732	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
696747002733	active sites [active]
696747002734	tetramer interface [polypeptide binding]; other site
696747002735	Hemerythrin; Region: Hemerythrin; cd12107
696747002736	Fe binding site [ion binding]; other site
696747002737	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
696747002738	TPR repeat; Region: TPR_11; pfam13414
696747002739	binding surface
696747002740	TPR motif; other site
696747002741	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002742	binding surface
696747002743	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747002744	TPR motif; other site
696747002745	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747002746	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002747	binding surface
696747002748	TPR motif; other site
696747002749	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002750	binding surface
696747002751	TPR motif; other site
696747002752	TPR repeat; Region: TPR_11; pfam13414
696747002753	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002754	binding surface
696747002755	TPR motif; other site
696747002756	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
696747002757	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
696747002758	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
696747002759	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
696747002760	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
696747002761	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
696747002762	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
696747002763	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
696747002764	thiS-thiF/thiG interaction site; other site
696747002765	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
696747002766	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
696747002767	HSP70 interaction site [polypeptide binding]; other site
696747002768	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
696747002769	substrate binding site [polypeptide binding]; other site
696747002770	dimer interface [polypeptide binding]; other site
696747002771	molecular chaperone DnaK; Provisional; Region: PRK13410
696747002772	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
696747002773	nucleotide binding site [chemical binding]; other site
696747002774	NEF interaction site [polypeptide binding]; other site
696747002775	SBD interface [polypeptide binding]; other site
696747002776	phytoene desaturase; Region: phytoene_desat; TIGR02731
696747002777	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696747002778	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
696747002779	active site lid residues [active]
696747002780	substrate binding pocket [chemical binding]; other site
696747002781	catalytic residues [active]
696747002782	substrate-Mg2+ binding site; other site
696747002783	aspartate-rich region 1; other site
696747002784	aspartate-rich region 2; other site
696747002785	helicase 45; Provisional; Region: PTZ00424
696747002786	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
696747002787	ATP binding site [chemical binding]; other site
696747002788	Mg++ binding site [ion binding]; other site
696747002789	motif III; other site
696747002790	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747002791	nucleotide binding region [chemical binding]; other site
696747002792	ATP-binding site [chemical binding]; other site
696747002793	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
696747002794	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
696747002795	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
696747002796	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
696747002797	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
696747002798	binding surface
696747002799	TPR motif; other site
696747002800	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002801	binding surface
696747002802	TPR repeat; Region: TPR_11; pfam13414
696747002803	TPR motif; other site
696747002804	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747002805	TPR repeat; Region: TPR_11; pfam13414
696747002806	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002807	binding surface
696747002808	TPR motif; other site
696747002809	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002810	binding surface
696747002811	TPR motif; other site
696747002812	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747002813	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002814	binding surface
696747002815	TPR motif; other site
696747002816	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002817	binding surface
696747002818	TPR motif; other site
696747002819	RNA polymerase sigma factor; Validated; Region: PRK05949
696747002820	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
696747002821	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
696747002822	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696747002823	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
696747002824	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696747002825	DNA binding residues [nucleotide binding]
696747002826	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
696747002827	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
696747002828	active site
696747002829	catalytic triad [active]
696747002830	oxyanion hole [active]
696747002831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747002832	active site
696747002833	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
696747002834	phosphorylation site [posttranslational modification]
696747002835	intermolecular recognition site; other site
696747002836	dimerization interface [polypeptide binding]; other site
696747002837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747002838	putative active site [active]
696747002839	heme pocket [chemical binding]; other site
696747002840	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747002841	metal binding site [ion binding]; metal-binding site
696747002842	active site
696747002843	I-site; other site
696747002844	Dynamin family; Region: Dynamin_N; pfam00350
696747002845	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
696747002846	G1 box; other site
696747002847	GTP/Mg2+ binding site [chemical binding]; other site
696747002848	Switch I region; other site
696747002849	G2 box; other site
696747002850	Switch II region; other site
696747002851	G3 box; other site
696747002852	G4 box; other site
696747002853	G5 box; other site
696747002854	Domain of unknown function (DUF697); Region: DUF697; pfam05128
696747002855	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
696747002856	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
696747002857	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
696747002858	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
696747002859	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
696747002860	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
696747002861	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747002862	putative active site [active]
696747002863	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
696747002864	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
696747002865	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
696747002866	Walker A/P-loop; other site
696747002867	ATP binding site [chemical binding]; other site
696747002868	Q-loop/lid; other site
696747002869	ABC transporter signature motif; other site
696747002870	Walker B; other site
696747002871	D-loop; other site
696747002872	H-loop/switch region; other site
696747002873	EVE domain; Region: EVE; pfam01878
696747002874	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
696747002875	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
696747002876	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
696747002877	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747002878	FeS/SAM binding site; other site
696747002879	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
696747002880	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
696747002881	active site
696747002882	metal binding site [ion binding]; metal-binding site
696747002883	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
696747002884	Uncharacterized conserved protein [Function unknown]; Region: COG2928
696747002885	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
696747002886	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
696747002887	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
696747002888	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
696747002889	putative active site [active]
696747002890	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002891	binding surface
696747002892	TPR motif; other site
696747002893	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747002894	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747002895	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002896	binding surface
696747002897	TPR motif; other site
696747002898	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747002899	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747002900	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002901	binding surface
696747002902	TPR motif; other site
696747002903	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747002904	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747002905	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002906	binding surface
696747002907	TPR motif; other site
696747002908	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747002909	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747002910	Tetratricopeptide repeat; Region: TPR_10; cl17452
696747002911	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747002912	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747002913	binding surface
696747002914	TPR motif; other site
696747002915	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747002916	CHAT domain; Region: CHAT; pfam12770
696747002917	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
696747002918	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
696747002919	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
696747002920	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
696747002921	substrate binding site [chemical binding]; other site
696747002922	glutamase interaction surface [polypeptide binding]; other site
696747002923	Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
696747002924	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747002925	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747002926	putative active site [active]
696747002927	putative nucleic acid binding site [nucleotide binding]; other site
696747002928	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747002929	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747002930	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747002931	active site
696747002932	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747002933	putative NTP binding site [chemical binding]; other site
696747002934	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747002935	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747002936	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
696747002937	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
696747002938	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
696747002939	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
696747002940	hinge; other site
696747002941	active site
696747002942	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
696747002943	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
696747002944	hexamer interface [polypeptide binding]; other site
696747002945	ligand binding site [chemical binding]; other site
696747002946	putative active site [active]
696747002947	NAD(P) binding site [chemical binding]; other site
696747002948	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
696747002949	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696747002950	active site
696747002951	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
696747002952	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
696747002953	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747002954	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747002955	phosphopeptide binding site; other site
696747002956	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747002957	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747002958	cyclase homology domain; Region: CHD; cd07302
696747002959	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747002960	nucleotidyl binding site; other site
696747002961	metal binding site [ion binding]; metal-binding site
696747002962	dimer interface [polypeptide binding]; other site
696747002963	S-layer homology domain; Region: SLH; pfam00395
696747002964	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
696747002965	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
696747002966	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
696747002967	Transglycosylase; Region: Transgly; pfam00912
696747002968	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
696747002969	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
696747002970	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
696747002971	UbiA prenyltransferase family; Region: UbiA; pfam01040
696747002972	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696747002973	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
696747002974	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696747002975	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747002976	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
696747002977	active site
696747002978	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696747002979	Protein kinase domain; Region: Pkinase; pfam00069
696747002980	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747002981	active site
696747002982	ATP binding site [chemical binding]; other site
696747002983	substrate binding site [chemical binding]; other site
696747002984	activation loop (A-loop); other site
696747002985	AAA ATPase domain; Region: AAA_16; pfam13191
696747002986	Predicted ATPase [General function prediction only]; Region: COG3899
696747002987	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747002988	GAF domain; Region: GAF; pfam01590
696747002989	PAS domain S-box; Region: sensory_box; TIGR00229
696747002990	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747002991	putative active site [active]
696747002992	heme pocket [chemical binding]; other site
696747002993	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747002994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747002995	ATP binding site [chemical binding]; other site
696747002996	Mg2+ binding site [ion binding]; other site
696747002997	G-X-G motif; other site
696747002998	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747002999	PAS fold; Region: PAS_3; pfam08447
696747003000	putative active site [active]
696747003001	heme pocket [chemical binding]; other site
696747003002	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747003003	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747003004	putative active site [active]
696747003005	heme pocket [chemical binding]; other site
696747003006	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747003007	putative active site [active]
696747003008	heme pocket [chemical binding]; other site
696747003009	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747003010	GAF domain; Region: GAF; pfam01590
696747003011	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747003012	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747003013	dimer interface [polypeptide binding]; other site
696747003014	phosphorylation site [posttranslational modification]
696747003015	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747003016	ATP binding site [chemical binding]; other site
696747003017	Mg2+ binding site [ion binding]; other site
696747003018	G-X-G motif; other site
696747003019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696747003020	putative substrate translocation pore; other site
696747003021	H+ Antiporter protein; Region: 2A0121; TIGR00900
696747003022	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
696747003023	DHH family; Region: DHH; pfam01368
696747003024	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
696747003025	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
696747003026	active site
696747003027	Zn binding site [ion binding]; other site
696747003028	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747003029	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747003030	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747003031	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747003032	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747003033	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747003034	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
696747003035	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
696747003036	putative acyl-acceptor binding pocket; other site
696747003037	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747003038	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747003039	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747003040	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747003041	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747003042	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747003043	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747003044	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747003045	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747003046	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
696747003047	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
696747003048	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
696747003049	Zn binding site [ion binding]; other site
696747003050	aspartate aminotransferase; Provisional; Region: PRK05764
696747003051	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696747003052	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747003053	homodimer interface [polypeptide binding]; other site
696747003054	catalytic residue [active]
696747003055	acylphosphatase; Provisional; Region: PRK14423
696747003056	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
696747003057	HEAT-like repeat; Region: HEAT_EZ; pfam13513
696747003058	protein binding surface [polypeptide binding]; other site
696747003059	HEAT repeats; Region: HEAT_2; pfam13646
696747003060	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
696747003061	SnoaL-like domain; Region: SnoaL_3; pfam13474
696747003062	Proline dehydrogenase; Region: Pro_dh; pfam01619
696747003063	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
696747003064	delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
696747003065	Glutamate binding site [chemical binding]; other site
696747003066	homodimer interface [polypeptide binding]; other site
696747003067	NAD binding site [chemical binding]; other site
696747003068	catalytic residues [active]
696747003069	hypothetical protein; Provisional; Region: PRK07394
696747003070	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
696747003071	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
696747003072	Transcriptional regulator [Transcription]; Region: LysR; COG0583
696747003073	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
696747003074	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
696747003075	dimerization interface [polypeptide binding]; other site
696747003076	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
696747003077	putative hydrophobic ligand binding site [chemical binding]; other site
696747003078	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
696747003079	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
696747003080	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
696747003081	dimer interface [polypeptide binding]; other site
696747003082	tetramer interface [polypeptide binding]; other site
696747003083	PYR/PP interface [polypeptide binding]; other site
696747003084	TPP binding site [chemical binding]; other site
696747003085	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
696747003086	TPP-binding site; other site
696747003087	Protein of unknown function (DUF565); Region: DUF565; pfam04483
696747003088	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
696747003089	active site
696747003090	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
696747003091	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
696747003092	transmembrane helices; other site
696747003093	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747003094	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747003095	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747003096	hypothetical protein; Reviewed; Region: PRK12497
696747003097	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
696747003098	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
696747003099	ribosomal protein L32; Validated; Region: rpl32; CHL00152
696747003100	2TM domain; Region: 2TM; pfam13239
696747003101	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747003102	AAA domain; Region: AAA_21; pfam13304
696747003103	Walker A/P-loop; other site
696747003104	ATP binding site [chemical binding]; other site
696747003105	Cache domain; Region: Cache_1; pfam02743
696747003106	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
696747003107	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747003108	dimerization interface [polypeptide binding]; other site
696747003109	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696747003110	dimer interface [polypeptide binding]; other site
696747003111	putative CheW interface [polypeptide binding]; other site
696747003112	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
696747003113	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
696747003114	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
696747003115	RibD C-terminal domain; Region: RibD_C; cl17279
696747003116	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
696747003117	Protein of unknown function, DUF482; Region: DUF482; pfam04339
696747003118	RRXRR protein; Region: RRXRR; pfam14239
696747003119	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747003120	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747003121	active site
696747003122	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747003123	TPR repeat; Region: TPR_11; pfam13414
696747003124	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747003125	binding surface
696747003126	TPR repeat; Region: TPR_11; pfam13414
696747003127	TPR motif; other site
696747003128	TPR repeat; Region: TPR_11; pfam13414
696747003129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747003130	binding surface
696747003131	TPR repeat; Region: TPR_11; pfam13414
696747003132	TPR motif; other site
696747003133	TPR repeat; Region: TPR_11; pfam13414
696747003134	AAA domain; Region: AAA_23; pfam13476
696747003135	AAA domain; Region: AAA_21; pfam13304
696747003136	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747003137	ABC transporter signature motif; other site
696747003138	Walker B; other site
696747003139	D-loop; other site
696747003140	H-loop/switch region; other site
696747003141	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747003142	TPR motif; other site
696747003143	Protein of unknown function (DUF760); Region: DUF760; pfam05542
696747003144	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
696747003145	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
696747003146	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
696747003147	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747003148	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
696747003149	ligand binding site [chemical binding]; other site
696747003150	flexible hinge region; other site
696747003151	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
696747003152	putative switch regulator; other site
696747003153	non-specific DNA interactions [nucleotide binding]; other site
696747003154	DNA binding site [nucleotide binding]
696747003155	sequence specific DNA binding site [nucleotide binding]; other site
696747003156	putative cAMP binding site [chemical binding]; other site
696747003157	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
696747003158	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
696747003159	NAD binding site [chemical binding]; other site
696747003160	homotetramer interface [polypeptide binding]; other site
696747003161	homodimer interface [polypeptide binding]; other site
696747003162	substrate binding site [chemical binding]; other site
696747003163	active site
696747003164	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
696747003165	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
696747003166	putative active site pocket [active]
696747003167	4-fold oligomerization interface [polypeptide binding]; other site
696747003168	metal binding residues [ion binding]; metal-binding site
696747003169	3-fold/trimer interface [polypeptide binding]; other site
696747003170	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
696747003171	AAA ATPase domain; Region: AAA_16; pfam13191
696747003172	NACHT domain; Region: NACHT; pfam05729
696747003173	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747003174	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747003175	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747003176	binding surface
696747003177	TPR motif; other site
696747003178	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747003179	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747003180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747003181	binding surface
696747003182	TPR motif; other site
696747003183	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747003184	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747003185	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747003186	binding surface
696747003187	TPR motif; other site
696747003188	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747003189	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747003190	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747003191	binding surface
696747003192	TPR motif; other site
696747003193	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747003194	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747003195	carboxyl-terminal processing protease; Provisional; Region: PLN00049
696747003196	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
696747003197	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
696747003198	protein binding site [polypeptide binding]; other site
696747003199	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
696747003200	Catalytic dyad [active]
696747003201	Uncharacterized conserved protein [Function unknown]; Region: COG0062
696747003202	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
696747003203	putative substrate binding site [chemical binding]; other site
696747003204	putative ATP binding site [chemical binding]; other site
696747003205	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696747003206	Peptidase family M23; Region: Peptidase_M23; pfam01551
696747003207	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
696747003208	nudix motif; other site
696747003209	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
696747003210	3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939
696747003211	putative NAD(P) binding site [chemical binding]; other site
696747003212	homotetramer interface [polypeptide binding]; other site
696747003213	active site
696747003214	homodimer interface [polypeptide binding]; other site
696747003215	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
696747003216	active site
696747003217	SAM binding site [chemical binding]; other site
696747003218	homodimer interface [polypeptide binding]; other site
696747003219	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
696747003220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747003221	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747003222	TPR motif; other site
696747003223	binding surface
696747003224	TPR repeat; Region: TPR_11; pfam13414
696747003225	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747003226	TPR motif; other site
696747003227	Domain of unknown function DUF39; Region: DUF39; pfam01837
696747003228	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
696747003229	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
696747003230	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747003231	TPR repeat; Region: TPR_11; pfam13414
696747003232	binding surface
696747003233	TPR motif; other site
696747003234	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
696747003235	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
696747003236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747003237	TPR motif; other site
696747003238	binding surface
696747003239	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696747003240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747003241	S-adenosylmethionine binding site [chemical binding]; other site
696747003242	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696747003243	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747003244	active site
696747003245	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
696747003246	Cephalosporin hydroxylase; Region: CmcI; pfam04989
696747003247	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747003248	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
696747003249	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
696747003250	extended (e) SDRs; Region: SDR_e; cd08946
696747003251	NAD(P) binding site [chemical binding]; other site
696747003252	active site
696747003253	substrate binding site [chemical binding]; other site
696747003254	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
696747003255	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
696747003256	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747003257	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747003258	S-adenosylmethionine binding site [chemical binding]; other site
696747003259	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
696747003260	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
696747003261	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747003262	NAD(P) binding site [chemical binding]; other site
696747003263	active site
696747003264	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
696747003265	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
696747003266	substrate binding site; other site
696747003267	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
696747003268	active site
696747003269	NTP binding site [chemical binding]; other site
696747003270	metal binding triad [ion binding]; metal-binding site
696747003271	antibiotic binding site [chemical binding]; other site
696747003272	Domain of unknown function DUF29; Region: DUF29; pfam01724
696747003273	Domain of unknown function DUF29; Region: DUF29; pfam01724
696747003274	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
696747003275	TPR motif; other site
696747003276	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
696747003277	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696747003278	motif II; other site
696747003279	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696747003280	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
696747003281	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696747003282	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
696747003283	trimer interface [polypeptide binding]; other site
696747003284	dimer interface [polypeptide binding]; other site
696747003285	putative active site [active]
696747003286	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
696747003287	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
696747003288	phosphoenolpyruvate synthase; Validated; Region: PRK06241
696747003289	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
696747003290	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
696747003291	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
696747003292	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
696747003293	acyl-activating enzyme (AAE) consensus motif; other site
696747003294	putative AMP binding site [chemical binding]; other site
696747003295	putative active site [active]
696747003296	putative CoA binding site [chemical binding]; other site
696747003297	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696747003298	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696747003299	active site
696747003300	metal binding site [ion binding]; metal-binding site
696747003301	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
696747003302	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
696747003303	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
696747003304	active site
696747003305	integral membrane protein MviN; Region: mviN; TIGR01695
696747003306	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
696747003307	Protein of unknown function (DUF422); Region: DUF422; cl00991
696747003308	O-Antigen ligase; Region: Wzy_C; pfam04932
696747003309	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
696747003310	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
696747003311	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
696747003312	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
696747003313	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
696747003314	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696747003315	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
696747003316	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
696747003317	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
696747003318	trimer interface [polypeptide binding]; other site
696747003319	active site
696747003320	substrate binding site [chemical binding]; other site
696747003321	CoA binding site [chemical binding]; other site
696747003322	agmatinase; Region: agmatinase; TIGR01230
696747003323	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
696747003324	putative active site [active]
696747003325	Mn binding site [ion binding]; other site
696747003326	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
696747003327	putative catalytic residue [active]
696747003328	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
696747003329	putative nucleotide binding site [chemical binding]; other site
696747003330	uridine monophosphate binding site [chemical binding]; other site
696747003331	homohexameric interface [polypeptide binding]; other site
696747003332	ribosome recycling factor; Reviewed; Region: frr; PRK00083
696747003333	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
696747003334	hinge region; other site
696747003335	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
696747003336	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
696747003337	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747003338	Phytochrome region; Region: PHY; pfam00360
696747003339	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
696747003340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747003341	ATP binding site [chemical binding]; other site
696747003342	Mg2+ binding site [ion binding]; other site
696747003343	G-X-G motif; other site
696747003344	Cytochrome c; Region: Cytochrom_C; cl11414
696747003345	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
696747003346	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
696747003347	Peptidase family S48; Region: Peptidase_S48; cl11616
696747003348	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
696747003349	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
696747003350	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
696747003351	SLBB domain; Region: SLBB; pfam10531
696747003352	SLBB domain; Region: SLBB; pfam10531
696747003353	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
696747003354	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
696747003355	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
696747003356	Nucleotide binding site [chemical binding]; other site
696747003357	DTAP/Switch II; other site
696747003358	Switch I; other site
696747003359	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747003360	PAS domain; Region: PAS_9; pfam13426
696747003361	putative active site [active]
696747003362	heme pocket [chemical binding]; other site
696747003363	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747003364	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747003365	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747003366	PAS domain; Region: PAS_9; pfam13426
696747003367	putative active site [active]
696747003368	heme pocket [chemical binding]; other site
696747003369	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747003370	GAF domain; Region: GAF; pfam01590
696747003371	PAS domain S-box; Region: sensory_box; TIGR00229
696747003372	PAS domain; Region: PAS_8; pfam13188
696747003373	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747003374	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747003375	metal binding site [ion binding]; metal-binding site
696747003376	active site
696747003377	I-site; other site
696747003378	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747003379	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
696747003380	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
696747003381	substrate binding site [chemical binding]; other site
696747003382	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
696747003383	substrate binding site [chemical binding]; other site
696747003384	ligand binding site [chemical binding]; other site
696747003385	XisH protein; Region: XisH; pfam08814
696747003386	XisI protein; Region: XisI; pfam08869
696747003387	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
696747003388	Domain of unknown function DUF29; Region: DUF29; pfam01724
696747003389	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
696747003390	putative active site [active]
696747003391	Domain of unknown function DUF29; Region: DUF29; pfam01724
696747003392	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
696747003393	P-loop; other site
696747003394	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
696747003395	Magnesium ion binding site [ion binding]; other site
696747003396	Restriction endonuclease; Region: Mrr_cat; pfam04471
696747003397	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
696747003398	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696747003399	dimerization interface [polypeptide binding]; other site
696747003400	DNA binding residues [nucleotide binding]
696747003401	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
696747003402	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
696747003403	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
696747003404	ParB-like nuclease domain; Region: ParB; smart00470
696747003405	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747003406	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747003407	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747003408	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747003409	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747003410	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747003411	Winged helix-turn helix; Region: HTH_29; pfam13551
696747003412	Homeodomain-like domain; Region: HTH_23; cl17451
696747003413	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747003414	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747003415	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747003416	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747003417	putative NTP binding site [chemical binding]; other site
696747003418	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747003419	nucleic acid binding site [nucleotide binding]; other site
696747003420	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747003421	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747003422	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747003423	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747003424	active site
696747003425	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747003426	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747003427	active site
696747003428	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747003429	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747003430	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747003431	Winged helix-turn helix; Region: HTH_33; pfam13592
696747003432	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747003433	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747003434	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747003435	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
696747003436	Domain of unknown function DUF21; Region: DUF21; pfam01595
696747003437	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
696747003438	Transporter associated domain; Region: CorC_HlyC; smart01091
696747003439	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
696747003440	substrate binding site [chemical binding]; other site
696747003441	putative lipid kinase; Reviewed; Region: PRK00861
696747003442	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
696747003443	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
696747003444	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
696747003445	metal-binding site [ion binding]
696747003446	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696747003447	Soluble P-type ATPase [General function prediction only]; Region: COG4087
696747003448	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747003449	putative active site [active]
696747003450	Tubulin like; Region: Tubulin_2; pfam13809
696747003451	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
696747003452	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
696747003453	active site
696747003454	NTP binding site [chemical binding]; other site
696747003455	metal binding triad [ion binding]; metal-binding site
696747003456	antibiotic binding site [chemical binding]; other site
696747003457	Uncharacterized conserved protein [Function unknown]; Region: COG2361
696747003458	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
696747003459	active site
696747003460	NTP binding site [chemical binding]; other site
696747003461	metal binding triad [ion binding]; metal-binding site
696747003462	antibiotic binding site [chemical binding]; other site
696747003463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
696747003464	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747003465	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
696747003466	Walker A motif; other site
696747003467	ATP binding site [chemical binding]; other site
696747003468	Walker B motif; other site
696747003469	arginine finger; other site
696747003470	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
696747003471	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
696747003472	HflX GTPase family; Region: HflX; cd01878
696747003473	G1 box; other site
696747003474	GTP/Mg2+ binding site [chemical binding]; other site
696747003475	Switch I region; other site
696747003476	G2 box; other site
696747003477	G3 box; other site
696747003478	Switch II region; other site
696747003479	G4 box; other site
696747003480	G5 box; other site
696747003481	S-layer homology domain; Region: SLH; pfam00395
696747003482	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
696747003483	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747003484	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747003485	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747003486	active site
696747003487	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747003488	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747003489	putative nucleic acid binding site [nucleotide binding]; other site
696747003490	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747003491	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747003492	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747003493	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747003494	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747003495	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747003496	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747003497	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747003498	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747003499	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747003500	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
696747003501	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
696747003502	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
696747003503	Competence protein; Region: Competence; pfam03772
696747003504	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
696747003505	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
696747003506	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
696747003507	Fasciclin domain; Region: Fasciclin; pfam02469
696747003508	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
696747003509	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
696747003510	putative ligand binding site [chemical binding]; other site
696747003511	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747003512	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747003513	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747003514	putative active site [active]
696747003515	heme pocket [chemical binding]; other site
696747003516	PAS fold; Region: PAS_4; pfam08448
696747003517	Heme NO binding associated; Region: HNOBA; pfam07701
696747003518	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
696747003519	cyclase homology domain; Region: CHD; cd07302
696747003520	nucleotidyl binding site; other site
696747003521	metal binding site [ion binding]; metal-binding site
696747003522	dimer interface [polypeptide binding]; other site
696747003523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747003524	AAA domain; Region: AAA_23; pfam13476
696747003525	Walker A/P-loop; other site
696747003526	ATP binding site [chemical binding]; other site
696747003527	Q-loop/lid; other site
696747003528	exonuclease SbcC; Region: sbcc; TIGR00618
696747003529	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747003530	ABC transporter signature motif; other site
696747003531	Walker B; other site
696747003532	D-loop; other site
696747003533	H-loop/switch region; other site
696747003534	ATP-grasp domain; Region: ATP-grasp_4; cl17255
696747003535	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
696747003536	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
696747003537	Transcription factor Tfb2; Region: Tfb2; cl04289
696747003538	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
696747003539	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
696747003540	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
696747003541	substrate-cofactor binding pocket; other site
696747003542	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747003543	catalytic residue [active]
696747003544	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
696747003545	acyl-CoA synthetase; Validated; Region: PRK05850
696747003546	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
696747003547	acyl-activating enzyme (AAE) consensus motif; other site
696747003548	active site
696747003549	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
696747003550	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
696747003551	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
696747003552	acyl-activating enzyme (AAE) consensus motif; other site
696747003553	active site
696747003554	H+ Antiporter protein; Region: 2A0121; TIGR00900
696747003555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696747003556	putative substrate translocation pore; other site
696747003557	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
696747003558	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
696747003559	NADP binding site [chemical binding]; other site
696747003560	active site
696747003561	putative substrate binding site [chemical binding]; other site
696747003562	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
696747003563	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
696747003564	putative active site [active]
696747003565	catalytic triad [active]
696747003566	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
696747003567	recombination protein RecR; Reviewed; Region: recR; PRK00076
696747003568	RecR protein; Region: RecR; pfam02132
696747003569	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
696747003570	putative active site [active]
696747003571	putative metal-binding site [ion binding]; other site
696747003572	tetramer interface [polypeptide binding]; other site
696747003573	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
696747003574	active site residue [active]
696747003575	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
696747003576	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
696747003577	allophycocyanin beta subunit; Region: apcB; CHL00088
696747003578	Phycobilisome protein; Region: Phycobilisome; cl08227
696747003579	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
696747003580	Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777
696747003581	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
696747003582	active site
696747003583	catalytic residues [active]
696747003584	DNA binding site [nucleotide binding]
696747003585	Int/Topo IB signature motif; other site
696747003586	MarR family; Region: MarR_2; cl17246
696747003587	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696747003588	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696747003589	hydrolase, alpha/beta fold family protein; Region: PLN02824
696747003590	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
696747003591	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
696747003592	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
696747003593	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
696747003594	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
696747003595	Walker A motif; other site
696747003596	ATP binding site [chemical binding]; other site
696747003597	Walker B motif; other site
696747003598	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
696747003599	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
696747003600	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696747003601	Walker A motif; other site
696747003602	ATP binding site [chemical binding]; other site
696747003603	Walker B motif; other site
696747003604	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
696747003605	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
696747003606	dimer interface [polypeptide binding]; other site
696747003607	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
696747003608	molecular chaperone DnaK; Provisional; Region: PRK13411
696747003609	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
696747003610	nucleotide binding site [chemical binding]; other site
696747003611	NEF interaction site [polypeptide binding]; other site
696747003612	SBD interface [polypeptide binding]; other site
696747003613	chaperone protein DnaJ; Provisional; Region: PRK14293
696747003614	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
696747003615	HSP70 interaction site [polypeptide binding]; other site
696747003616	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
696747003617	Zn binding sites [ion binding]; other site
696747003618	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
696747003619	dimer interface [polypeptide binding]; other site
696747003620	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
696747003621	CPxP  motif; other site
696747003622	GTPase RsgA; Reviewed; Region: PRK12289
696747003623	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
696747003624	RNA binding site [nucleotide binding]; other site
696747003625	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
696747003626	GTPase/Zn-binding domain interface [polypeptide binding]; other site
696747003627	GTP/Mg2+ binding site [chemical binding]; other site
696747003628	G4 box; other site
696747003629	G5 box; other site
696747003630	G1 box; other site
696747003631	Switch I region; other site
696747003632	G2 box; other site
696747003633	G3 box; other site
696747003634	Switch II region; other site
696747003635	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
696747003636	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
696747003637	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
696747003638	[4Fe-4S] binding site [ion binding]; other site
696747003639	molybdopterin cofactor binding site; other site
696747003640	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
696747003641	molybdopterin cofactor binding site; other site
696747003642	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
696747003643	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696747003644	putative substrate translocation pore; other site
696747003645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696747003646	cytosine deaminase-like protein; Validated; Region: PRK07583
696747003647	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
696747003648	active site
696747003649	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
696747003650	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
696747003651	SLBB domain; Region: SLBB; pfam10531
696747003652	SLBB domain; Region: SLBB; pfam10531
696747003653	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
696747003654	Chain length determinant protein; Region: Wzz; pfam02706
696747003655	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
696747003656	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696747003657	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
696747003658	O-Antigen ligase; Region: Wzy_C; pfam04932
696747003659	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
696747003660	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
696747003661	Pleckstrin homology-like domain; Region: PH-like; cl17171
696747003662	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696747003663	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747003664	NAD(P) binding site [chemical binding]; other site
696747003665	active site
696747003666	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
696747003667	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
696747003668	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
696747003669	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747003670	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696747003671	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
696747003672	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696747003673	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
696747003674	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
696747003675	oxidoreductase; Provisional; Region: PRK06196
696747003676	putative NAD(P) binding site [chemical binding]; other site
696747003677	active site
696747003678	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
696747003679	carotene isomerase; Region: carot_isom; TIGR02730
696747003680	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696747003681	hydroxyglutarate oxidase; Provisional; Region: PRK11728
696747003682	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696747003683	active site
696747003684	YGGT family; Region: YGGT; pfam02325
696747003685	Domain of unknown function (DUF202); Region: DUF202; cl09954
696747003686	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
696747003687	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
696747003688	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696747003689	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696747003690	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
696747003691	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696747003692	motif II; other site
696747003693	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
696747003694	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
696747003695	putative active site [active]
696747003696	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
696747003697	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
696747003698	PQQ-like domain; Region: PQQ_2; pfam13360
696747003699	Trp docking motif [polypeptide binding]; other site
696747003700	active site
696747003701	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
696747003702	Ca2+ binding site [ion binding]; other site
696747003703	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
696747003704	Ca2+ binding site [ion binding]; other site
696747003705	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
696747003706	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696747003707	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696747003708	DNA binding residues [nucleotide binding]
696747003709	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747003710	binding surface
696747003711	TPR motif; other site
696747003712	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
696747003713	binding surface
696747003714	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747003715	TPR motif; other site
696747003716	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
696747003717	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
696747003718	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
696747003719	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747003720	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747003721	putative active site [active]
696747003722	putative NTP binding site [chemical binding]; other site
696747003723	putative nucleic acid binding site [nucleotide binding]; other site
696747003724	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747003725	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747003726	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747003727	active site
696747003728	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747003729	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747003730	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747003731	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
696747003732	putative active site [active]
696747003733	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
696747003734	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
696747003735	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696747003736	catalytic residue [active]
696747003737	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
696747003738	FeS assembly protein SufD; Region: sufD; TIGR01981
696747003739	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
696747003740	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
696747003741	Walker A/P-loop; other site
696747003742	ATP binding site [chemical binding]; other site
696747003743	Q-loop/lid; other site
696747003744	ABC transporter signature motif; other site
696747003745	Walker B; other site
696747003746	D-loop; other site
696747003747	H-loop/switch region; other site
696747003748	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
696747003749	putative ABC transporter; Region: ycf24; CHL00085
696747003750	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696747003751	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
696747003752	putative DNA binding site [nucleotide binding]; other site
696747003753	putative Zn2+ binding site [ion binding]; other site
696747003754	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
696747003755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747003756	Walker A motif; other site
696747003757	ATP binding site [chemical binding]; other site
696747003758	Walker B motif; other site
696747003759	arginine finger; other site
696747003760	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
696747003761	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
696747003762	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
696747003763	nucleotide binding site [chemical binding]; other site
696747003764	CHAT domain; Region: CHAT; pfam12770
696747003765	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
696747003766	putative active site [active]
696747003767	homoserine dehydrogenase; Provisional; Region: PRK06349
696747003768	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
696747003769	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
696747003770	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
696747003771	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747003772	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747003773	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747003774	structural tetrad; other site
696747003775	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
696747003776	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
696747003777	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
696747003778	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
696747003779	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
696747003780	intersubunit interface [polypeptide binding]; other site
696747003781	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
696747003782	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
696747003783	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
696747003784	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
696747003785	putative PBP binding regions; other site
696747003786	ABC-ATPase subunit  interface; other site
696747003787	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
696747003788	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696747003789	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
696747003790	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
696747003791	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
696747003792	putative homodimer interface [polypeptide binding]; other site
696747003793	active site
696747003794	SAM binding site [chemical binding]; other site
696747003795	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
696747003796	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
696747003797	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
696747003798	DNA polymerase III subunit delta; Validated; Region: PRK07452
696747003799	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
696747003800	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
696747003801	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
696747003802	HSP70 interaction site [polypeptide binding]; other site
696747003803	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
696747003804	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
696747003805	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
696747003806	catalytic residue [active]
696747003807	putative FPP diphosphate  binding site; other site
696747003808	putative FPP binding hydrophobic cleft; other site
696747003809	dimer interface [polypeptide binding]; other site
696747003810	putative IPP diphosphate binding site; other site
696747003811	Uncharacterized conserved protein [Function unknown]; Region: COG1624
696747003812	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
696747003813	diaminopimelate decarboxylase; Region: lysA; TIGR01048
696747003814	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
696747003815	active site
696747003816	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
696747003817	substrate binding site [chemical binding]; other site
696747003818	catalytic residues [active]
696747003819	dimer interface [polypeptide binding]; other site
696747003820	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
696747003821	Clp protease ATP binding subunit; Region: clpC; CHL00095
696747003822	Clp amino terminal domain; Region: Clp_N; pfam02861
696747003823	Clp amino terminal domain; Region: Clp_N; pfam02861
696747003824	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747003825	Walker A motif; other site
696747003826	ATP binding site [chemical binding]; other site
696747003827	Walker B motif; other site
696747003828	arginine finger; other site
696747003829	UvrB/uvrC motif; Region: UVR; pfam02151
696747003830	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747003831	Walker A motif; other site
696747003832	ATP binding site [chemical binding]; other site
696747003833	Walker B motif; other site
696747003834	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
696747003835	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
696747003836	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747003837	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747003838	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
696747003839	MoaE interaction surface [polypeptide binding]; other site
696747003840	MoeB interaction surface [polypeptide binding]; other site
696747003841	thiocarboxylated glycine; other site
696747003842	threonine synthase; Validated; Region: PRK07591
696747003843	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
696747003844	homodimer interface [polypeptide binding]; other site
696747003845	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747003846	catalytic residue [active]
696747003847	multifunctional aminopeptidase A; Provisional; Region: PRK00913
696747003848	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
696747003849	interface (dimer of trimers) [polypeptide binding]; other site
696747003850	Substrate-binding/catalytic site; other site
696747003851	Zn-binding sites [ion binding]; other site
696747003852	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747003853	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747003854	putative active site [active]
696747003855	heme pocket [chemical binding]; other site
696747003856	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747003857	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747003858	putative active site [active]
696747003859	heme pocket [chemical binding]; other site
696747003860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747003861	putative active site [active]
696747003862	heme pocket [chemical binding]; other site
696747003863	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747003864	dimer interface [polypeptide binding]; other site
696747003865	phosphorylation site [posttranslational modification]
696747003866	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747003867	ATP binding site [chemical binding]; other site
696747003868	Mg2+ binding site [ion binding]; other site
696747003869	G-X-G motif; other site
696747003870	Predicted deacylase [General function prediction only]; Region: COG3608
696747003871	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
696747003872	putative active site [active]
696747003873	Zn binding site [ion binding]; other site
696747003874	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
696747003875	dimer interface [polypeptide binding]; other site
696747003876	ADP-ribose binding site [chemical binding]; other site
696747003877	active site
696747003878	nudix motif; other site
696747003879	metal binding site [ion binding]; metal-binding site
696747003880	AMIN domain; Region: AMIN; pfam11741
696747003881	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
696747003882	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
696747003883	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
696747003884	metal binding site [ion binding]; metal-binding site
696747003885	dimer interface [polypeptide binding]; other site
696747003886	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
696747003887	TAP-like protein; Region: Abhydrolase_4; pfam08386
696747003888	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
696747003889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747003890	dimer interface [polypeptide binding]; other site
696747003891	conserved gate region; other site
696747003892	putative PBP binding loops; other site
696747003893	ABC-ATPase subunit interface; other site
696747003894	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696747003895	active site
696747003896	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
696747003897	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
696747003898	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
696747003899	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
696747003900	ligand binding site [chemical binding]; other site
696747003901	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
696747003902	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
696747003903	putative active site [active]
696747003904	substrate binding site [chemical binding]; other site
696747003905	putative cosubstrate binding site; other site
696747003906	catalytic site [active]
696747003907	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
696747003908	substrate binding site [chemical binding]; other site
696747003909	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
696747003910	anti sigma factor interaction site; other site
696747003911	regulatory phosphorylation site [posttranslational modification]; other site
696747003912	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
696747003913	Bacterial sugar transferase; Region: Bac_transf; pfam02397
696747003914	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
696747003915	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
696747003916	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
696747003917	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
696747003918	MPT binding site; other site
696747003919	trimer interface [polypeptide binding]; other site
696747003920	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747003921	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747003922	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696747003923	Zn2+ binding site [ion binding]; other site
696747003924	Mg2+ binding site [ion binding]; other site
696747003925	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696747003926	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
696747003927	aromatic arch; other site
696747003928	DCoH dimer interaction site [polypeptide binding]; other site
696747003929	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
696747003930	DCoH tetramer interaction site [polypeptide binding]; other site
696747003931	substrate binding site [chemical binding]; other site
696747003932	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747003933	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
696747003934	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
696747003935	Tic22-like family; Region: Tic22; pfam04278
696747003936	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
696747003937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747003938	S-adenosylmethionine binding site [chemical binding]; other site
696747003939	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
696747003940	putative homodimer interface [polypeptide binding]; other site
696747003941	putative homotetramer interface [polypeptide binding]; other site
696747003942	putative allosteric switch controlling residues; other site
696747003943	putative metal binding site [ion binding]; other site
696747003944	putative homodimer-homodimer interface [polypeptide binding]; other site
696747003945	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
696747003946	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
696747003947	HlyD family secretion protein; Region: HlyD_3; pfam13437
696747003948	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
696747003949	GUN4-like; Region: GUN4; pfam05419
696747003950	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
696747003951	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
696747003952	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
696747003953	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
696747003954	Uncharacterized conserved protein [Function unknown]; Region: COG3937
696747003955	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
696747003956	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
696747003957	Phage tail repeat like; Region: PTR; pfam12789
696747003958	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747003959	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
696747003960	active site
696747003961	DNA binding site [nucleotide binding]
696747003962	Int/Topo IB signature motif; other site
696747003963	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
696747003964	putative dimer interface [polypeptide binding]; other site
696747003965	active site pocket [active]
696747003966	putative cataytic base [active]
696747003967	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
696747003968	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696747003969	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747003970	ligand binding site [chemical binding]; other site
696747003971	flexible hinge region; other site
696747003972	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
696747003973	putative switch regulator; other site
696747003974	non-specific DNA interactions [nucleotide binding]; other site
696747003975	DNA binding site [nucleotide binding]
696747003976	sequence specific DNA binding site [nucleotide binding]; other site
696747003977	putative cAMP binding site [chemical binding]; other site
696747003978	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747003979	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
696747003980	putative ADP-binding pocket [chemical binding]; other site
696747003981	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747003982	Bacterial sugar transferase; Region: Bac_transf; pfam02397
696747003983	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
696747003984	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
696747003985	NADP-binding site; other site
696747003986	homotetramer interface [polypeptide binding]; other site
696747003987	substrate binding site [chemical binding]; other site
696747003988	homodimer interface [polypeptide binding]; other site
696747003989	active site
696747003990	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
696747003991	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
696747003992	NADP binding site [chemical binding]; other site
696747003993	active site
696747003994	putative substrate binding site [chemical binding]; other site
696747003995	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
696747003996	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
696747003997	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
696747003998	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747003999	dimer interface [polypeptide binding]; other site
696747004000	conserved gate region; other site
696747004001	putative PBP binding loops; other site
696747004002	ABC-ATPase subunit interface; other site
696747004003	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
696747004004	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696747004005	Coenzyme A binding pocket [chemical binding]; other site
696747004006	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
696747004007	Protein of unknown function (DUF938); Region: DUF938; pfam06080
696747004008	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
696747004009	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
696747004010	antiporter inner membrane protein; Provisional; Region: PRK11670
696747004011	Domain of unknown function DUF59; Region: DUF59; pfam01883
696747004012	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
696747004013	Walker A motif; other site
696747004014	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
696747004015	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
696747004016	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
696747004017	anti sigma factor interaction site; other site
696747004018	regulatory phosphorylation site [posttranslational modification]; other site
696747004019	Thf1-like protein; Reviewed; Region: PRK13266
696747004020	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
696747004021	Late competence development protein ComFB; Region: ComFB; pfam10719
696747004022	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696747004023	Peptidase family M23; Region: Peptidase_M23; pfam01551
696747004024	Acylphosphatase; Region: Acylphosphatase; pfam00708
696747004025	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
696747004026	HypF finger; Region: zf-HYPF; pfam07503
696747004027	HypF finger; Region: zf-HYPF; pfam07503
696747004028	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
696747004029	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374
696747004030	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
696747004031	active site
696747004032	PHP Thumb interface [polypeptide binding]; other site
696747004033	metal binding site [ion binding]; metal-binding site
696747004034	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
696747004035	generic binding surface II; other site
696747004036	generic binding surface I; other site
696747004037	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
696747004038	GSH binding site [chemical binding]; other site
696747004039	catalytic residues [active]
696747004040	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
696747004041	Domain of unknown function (DUF1817); Region: DUF1817; pfam08847
696747004042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747004043	Response regulator receiver domain; Region: Response_reg; pfam00072
696747004044	active site
696747004045	phosphorylation site [posttranslational modification]
696747004046	intermolecular recognition site; other site
696747004047	dimerization interface [polypeptide binding]; other site
696747004048	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
696747004049	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
696747004050	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
696747004051	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696747004052	active site
696747004053	metal binding site [ion binding]; metal-binding site
696747004054	acetylornithine aminotransferase; Provisional; Region: PRK02627
696747004055	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
696747004056	inhibitor-cofactor binding pocket; inhibition site
696747004057	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747004058	catalytic residue [active]
696747004059	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
696747004060	cyclase homology domain; Region: CHD; cd07302
696747004061	nucleotidyl binding site; other site
696747004062	metal binding site [ion binding]; metal-binding site
696747004063	dimer interface [polypeptide binding]; other site
696747004064	Bacterial SH3 domain; Region: SH3_3; cl17532
696747004065	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747004066	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747004067	phosphopeptide binding site; other site
696747004068	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747004069	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747004070	phosphopeptide binding site; other site
696747004071	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
696747004072	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
696747004073	Walker A/P-loop; other site
696747004074	ATP binding site [chemical binding]; other site
696747004075	Q-loop/lid; other site
696747004076	ABC transporter signature motif; other site
696747004077	Walker B; other site
696747004078	D-loop; other site
696747004079	H-loop/switch region; other site
696747004080	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
696747004081	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
696747004082	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
696747004083	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747004084	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747004085	active site
696747004086	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696747004087	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696747004088	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
696747004089	putative metal binding site; other site
696747004090	putative acyl transferase; Provisional; Region: PRK10502
696747004091	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
696747004092	putative trimer interface [polypeptide binding]; other site
696747004093	putative active site [active]
696747004094	putative substrate binding site [chemical binding]; other site
696747004095	putative CoA binding site [chemical binding]; other site
696747004096	proton extrusion protein PcxA; Provisional; Region: PRK02507
696747004097	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747004098	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747004099	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747004100	Putative integral membrane protein DUF46; Region: DUF46; cl17511
696747004101	TIGR03032 family protein; Region: TIGR03032
696747004102	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004103	binding surface
696747004104	TPR motif; other site
696747004105	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
696747004106	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004107	binding surface
696747004108	TPR motif; other site
696747004109	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004110	binding surface
696747004111	TPR motif; other site
696747004112	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
696747004113	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
696747004114	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
696747004115	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
696747004116	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
696747004117	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
696747004118	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
696747004119	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747004120	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
696747004121	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747004122	dimer interface [polypeptide binding]; other site
696747004123	phosphorylation site [posttranslational modification]
696747004124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747004125	ATP binding site [chemical binding]; other site
696747004126	Mg2+ binding site [ion binding]; other site
696747004127	G-X-G motif; other site
696747004128	Predicted transcriptional regulators [Transcription]; Region: COG1725
696747004129	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696747004130	DNA-binding site [nucleotide binding]; DNA binding site
696747004131	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
696747004132	30S ribosomal protein S1; Reviewed; Region: PRK07400
696747004133	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
696747004134	RNA binding site [nucleotide binding]; other site
696747004135	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
696747004136	RNA binding site [nucleotide binding]; other site
696747004137	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
696747004138	RNA binding site [nucleotide binding]; other site
696747004139	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
696747004140	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
696747004141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696747004142	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696747004143	putative substrate translocation pore; other site
696747004144	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
696747004145	active site residue [active]
696747004146	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
696747004147	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696747004148	Zn2+ binding site [ion binding]; other site
696747004149	Mg2+ binding site [ion binding]; other site
696747004150	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
696747004151	synthetase active site [active]
696747004152	NTP binding site [chemical binding]; other site
696747004153	metal binding site [ion binding]; metal-binding site
696747004154	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
696747004155	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
696747004156	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747004157	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747004158	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
696747004159	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004160	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004161	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004162	binding surface
696747004163	TPR motif; other site
696747004164	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004165	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004166	binding surface
696747004167	TPR motif; other site
696747004168	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004169	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004170	binding surface
696747004171	TPR motif; other site
696747004172	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004173	CHAT domain; Region: CHAT; pfam12770
696747004174	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
696747004175	CHAT domain; Region: CHAT; cl17868
696747004176	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
696747004177	CHASE2 domain; Region: CHASE2; pfam05226
696747004178	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
696747004179	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747004180	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747004181	active site
696747004182	ATP binding site [chemical binding]; other site
696747004183	substrate binding site [chemical binding]; other site
696747004184	activation loop (A-loop); other site
696747004185	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
696747004186	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747004187	putative active site [active]
696747004188	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747004189	putative active site [active]
696747004190	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747004191	putative active site [active]
696747004192	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747004193	putative active site [active]
696747004194	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747004195	putative active site [active]
696747004196	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747004197	putative active site [active]
696747004198	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747004199	putative active site [active]
696747004200	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747004201	putative active site [active]
696747004202	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747004203	putative active site [active]
696747004204	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747004205	putative active site [active]
696747004206	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747004207	putative active site [active]
696747004208	Clp protease ATP binding subunit; Region: clpC; CHL00095
696747004209	Clp amino terminal domain; Region: Clp_N; pfam02861
696747004210	Clp amino terminal domain; Region: Clp_N; pfam02861
696747004211	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747004212	Walker A motif; other site
696747004213	ATP binding site [chemical binding]; other site
696747004214	Walker B motif; other site
696747004215	arginine finger; other site
696747004216	UvrB/uvrC motif; Region: UVR; pfam02151
696747004217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747004218	Walker A motif; other site
696747004219	ATP binding site [chemical binding]; other site
696747004220	Walker B motif; other site
696747004221	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
696747004222	META domain; Region: META; pfam03724
696747004223	META domain; Region: META; pfam03724
696747004224	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
696747004225	Peptidase family M50; Region: Peptidase_M50; pfam02163
696747004226	active site
696747004227	putative substrate binding region [chemical binding]; other site
696747004228	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696747004229	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747004230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747004231	putative active site [active]
696747004232	heme pocket [chemical binding]; other site
696747004233	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747004234	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747004235	dimer interface [polypeptide binding]; other site
696747004236	phosphorylation site [posttranslational modification]
696747004237	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747004238	ATP binding site [chemical binding]; other site
696747004239	Mg2+ binding site [ion binding]; other site
696747004240	G-X-G motif; other site
696747004241	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696747004242	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
696747004243	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
696747004244	iron-sulfur cluster [ion binding]; other site
696747004245	[2Fe-2S] cluster binding site [ion binding]; other site
696747004246	Uncharacterized conserved protein [Function unknown]; Region: COG3349
696747004247	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
696747004248	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
696747004249	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
696747004250	metal-binding site [ion binding]
696747004251	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696747004252	Soluble P-type ATPase [General function prediction only]; Region: COG4087
696747004253	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747004254	Walker A motif; other site
696747004255	ATP binding site [chemical binding]; other site
696747004256	Walker B motif; other site
696747004257	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
696747004258	protein-splicing catalytic site; other site
696747004259	thioester formation/cholesterol transfer; other site
696747004260	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
696747004261	DNA polymerase III subunit delta'; Validated; Region: PRK08485
696747004262	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
696747004263	HEAT repeats; Region: HEAT_2; pfam13646
696747004264	HEAT repeats; Region: HEAT_2; pfam13646
696747004265	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
696747004266	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
696747004267	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
696747004268	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
696747004269	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
696747004270	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
696747004271	Phycobilisome protein; Region: Phycobilisome; cl08227
696747004272	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
696747004273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747004274	dimer interface [polypeptide binding]; other site
696747004275	conserved gate region; other site
696747004276	ABC-ATPase subunit interface; other site
696747004277	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
696747004278	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
696747004279	active site
696747004280	Substrate binding site; other site
696747004281	Mg++ binding site; other site
696747004282	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
696747004283	putative CoA binding site [chemical binding]; other site
696747004284	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
696747004285	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
696747004286	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
696747004287	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
696747004288	dimer interface [polypeptide binding]; other site
696747004289	ssDNA binding site [nucleotide binding]; other site
696747004290	tetramer (dimer of dimers) interface [polypeptide binding]; other site
696747004291	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747004292	ATP binding site [chemical binding]; other site
696747004293	G-X-G motif; other site
696747004294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
696747004295	G-X-G motif; other site
696747004296	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747004297	phosphorylation site [posttranslational modification]
696747004298	dimer interface [polypeptide binding]; other site
696747004299	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
696747004300	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
696747004301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747004302	phosphorylation site [posttranslational modification]
696747004303	intermolecular recognition site; other site
696747004304	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
696747004305	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
696747004306	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
696747004307	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696747004308	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
696747004309	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
696747004310	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
696747004311	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
696747004312	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747004313	nucleic acid binding site [nucleotide binding]; other site
696747004314	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747004315	active site
696747004316	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004317	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747004318	putative active site [active]
696747004319	putative nucleic acid binding site [nucleotide binding]; other site
696747004320	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747004321	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747004322	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747004323	active site
696747004324	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004325	putative NTP binding site [chemical binding]; other site
696747004326	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004327	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004328	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747004329	Helix-turn-helix domain; Region: HTH_28; pfam13518
696747004330	Winged helix-turn helix; Region: HTH_33; pfam13592
696747004331	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747004332	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747004333	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004334	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747004335	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004336	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004337	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747004338	putative active site [active]
696747004339	putative nucleic acid binding site [nucleotide binding]; other site
696747004340	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747004341	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
696747004342	30S subunit binding site; other site
696747004343	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747004344	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747004345	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747004346	Winged helix-turn helix; Region: HTH_29; pfam13551
696747004347	Homeodomain-like domain; Region: HTH_23; cl17451
696747004348	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004349	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004350	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747004351	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004352	putative active site [active]
696747004353	putative NTP binding site [chemical binding]; other site
696747004354	putative nucleic acid binding site [nucleotide binding]; other site
696747004355	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747004356	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747004357	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747004358	active site
696747004359	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747004360	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747004361	Winged helix-turn helix; Region: HTH_29; pfam13551
696747004362	Homeodomain-like domain; Region: HTH_23; cl17451
696747004363	RRXRR protein; Region: RRXRR; pfam14239
696747004364	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747004365	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747004366	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747004367	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747004368	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
696747004369	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
696747004370	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
696747004371	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
696747004372	FAD binding domain; Region: FAD_binding_4; pfam01565
696747004373	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
696747004374	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
696747004375	Clp protease; Region: CLP_protease; pfam00574
696747004376	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
696747004377	oligomer interface [polypeptide binding]; other site
696747004378	active site residues [active]
696747004379	Exoribonuclease R [Transcription]; Region: VacB; COG0557
696747004380	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
696747004381	RNB domain; Region: RNB; pfam00773
696747004382	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
696747004383	RNA binding site [nucleotide binding]; other site
696747004384	CHASE3 domain; Region: CHASE3; pfam05227
696747004385	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747004386	cyclase homology domain; Region: CHD; cd07302
696747004387	nucleotidyl binding site; other site
696747004388	metal binding site [ion binding]; metal-binding site
696747004389	dimer interface [polypeptide binding]; other site
696747004390	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
696747004391	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
696747004392	IHF dimer interface [polypeptide binding]; other site
696747004393	IHF - DNA interface [nucleotide binding]; other site
696747004394	magnesium chelatase subunit H; Provisional; Region: PRK12493
696747004395	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
696747004396	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
696747004397	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
696747004398	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
696747004399	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
696747004400	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
696747004401	TrkA-N domain; Region: TrkA_N; pfam02254
696747004402	TrkA-C domain; Region: TrkA_C; pfam02080
696747004403	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
696747004404	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
696747004405	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
696747004406	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747004407	putative active site [active]
696747004408	ribonuclease PH; Reviewed; Region: rph; PRK00173
696747004409	Ribonuclease PH; Region: RNase_PH_bact; cd11362
696747004410	hexamer interface [polypeptide binding]; other site
696747004411	active site
696747004412	S-layer homology domain; Region: SLH; pfam00395
696747004413	S-layer homology domain; Region: SLH; pfam00395
696747004414	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
696747004415	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747004416	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004417	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747004418	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747004419	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747004420	active site
696747004421	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747004422	Winged helix-turn helix; Region: HTH_33; pfam13592
696747004423	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747004424	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747004425	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696747004426	active site
696747004427	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747004428	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747004429	active site
696747004430	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696747004431	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747004432	TPR repeat; Region: TPR_11; pfam13414
696747004433	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004434	binding surface
696747004435	TPR motif; other site
696747004436	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004437	TPR repeat; Region: TPR_11; pfam13414
696747004438	binding surface
696747004439	TPR motif; other site
696747004440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004441	binding surface
696747004442	TPR motif; other site
696747004443	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004444	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004445	binding surface
696747004446	TPR motif; other site
696747004447	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
696747004448	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004449	TPR repeat; Region: TPR_11; pfam13414
696747004450	binding surface
696747004451	TPR motif; other site
696747004452	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004453	binding surface
696747004454	TPR repeat; Region: TPR_11; pfam13414
696747004455	TPR motif; other site
696747004456	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747004457	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747004458	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004459	binding surface
696747004460	TPR motif; other site
696747004461	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747004462	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004463	binding surface
696747004464	TPR motif; other site
696747004465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004466	TPR motif; other site
696747004467	binding surface
696747004468	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004469	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004470	binding surface
696747004471	TPR motif; other site
696747004472	Protein of unknown function (DUF563); Region: DUF563; pfam04577
696747004473	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004474	TPR repeat; Region: TPR_11; pfam13414
696747004475	binding surface
696747004476	TPR motif; other site
696747004477	TPR repeat; Region: TPR_11; pfam13414
696747004478	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004479	binding surface
696747004480	TPR motif; other site
696747004481	TPR repeat; Region: TPR_11; pfam13414
696747004482	Tetratricopeptide repeat; Region: TPR_1; pfam00515
696747004483	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747004484	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004485	TPR motif; other site
696747004486	binding surface
696747004487	TPR repeat; Region: TPR_11; pfam13414
696747004488	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004489	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747004490	TPR motif; other site
696747004491	binding surface
696747004492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004493	binding surface
696747004494	TPR motif; other site
696747004495	Methyltransferase domain; Region: Methyltransf_24; pfam13578
696747004496	TPR repeat; Region: TPR_11; pfam13414
696747004497	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004498	binding surface
696747004499	TPR motif; other site
696747004500	TPR repeat; Region: TPR_11; pfam13414
696747004501	TPR repeat; Region: TPR_11; pfam13414
696747004502	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004503	binding surface
696747004504	TPR motif; other site
696747004505	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004506	TPR motif; other site
696747004507	binding surface
696747004508	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
696747004509	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004510	binding surface
696747004511	TPR motif; other site
696747004512	TPR repeat; Region: TPR_11; pfam13414
696747004513	TPR repeat; Region: TPR_11; pfam13414
696747004514	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747004515	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004516	binding surface
696747004517	TPR motif; other site
696747004518	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004519	binding surface
696747004520	TPR motif; other site
696747004521	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004522	binding surface
696747004523	TPR motif; other site
696747004524	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
696747004525	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747004526	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
696747004527	active site
696747004528	ATP binding site [chemical binding]; other site
696747004529	substrate binding site [chemical binding]; other site
696747004530	activation loop (A-loop); other site
696747004531	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696747004532	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
696747004533	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
696747004534	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
696747004535	Mechanosensitive ion channel; Region: MS_channel; pfam00924
696747004536	adenylosuccinate lyase; Provisional; Region: PRK07380
696747004537	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
696747004538	tetramer interface [polypeptide binding]; other site
696747004539	active site
696747004540	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
696747004541	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747004542	Homeodomain-like domain; Region: HTH_23; cl17451
696747004543	Winged helix-turn helix; Region: HTH_33; pfam13592
696747004544	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747004545	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747004546	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747004547	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747004548	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004549	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004550	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004551	putative NTP binding site [chemical binding]; other site
696747004552	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004553	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747004554	putative active site [active]
696747004555	putative nucleic acid binding site [nucleotide binding]; other site
696747004556	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747004557	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747004558	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747004559	active site
696747004560	Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
696747004561	Protein of unknown function (DUF1347); Region: DUF1347; pfam07079
696747004562	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004563	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747004564	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004565	putative active site [active]
696747004566	putative NTP binding site [chemical binding]; other site
696747004567	putative nucleic acid binding site [nucleotide binding]; other site
696747004568	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747004569	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747004570	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747004571	active site
696747004572	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696747004573	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
696747004574	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
696747004575	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
696747004576	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
696747004577	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
696747004578	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
696747004579	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
696747004580	active site
696747004581	ADP/pyrophosphate binding site [chemical binding]; other site
696747004582	dimerization interface [polypeptide binding]; other site
696747004583	allosteric effector site; other site
696747004584	fructose-1,6-bisphosphate binding site; other site
696747004585	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696747004586	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747004587	ligand binding site [chemical binding]; other site
696747004588	flexible hinge region; other site
696747004589	transaldolase-like protein; Provisional; Region: PTZ00411
696747004590	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
696747004591	active site
696747004592	dimer interface [polypeptide binding]; other site
696747004593	catalytic residue [active]
696747004594	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
696747004595	Winged helix-turn helix; Region: HTH_33; pfam13592
696747004596	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747004597	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004598	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004599	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747004600	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004601	putative active site [active]
696747004602	putative NTP binding site [chemical binding]; other site
696747004603	putative nucleic acid binding site [nucleotide binding]; other site
696747004604	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747004605	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747004606	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747004607	active site
696747004608	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004609	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004610	putative NTP binding site [chemical binding]; other site
696747004611	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004612	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747004613	putative active site [active]
696747004614	putative nucleic acid binding site [nucleotide binding]; other site
696747004615	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747004616	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747004617	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747004618	active site
696747004619	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
696747004620	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
696747004621	Winged helix-turn helix; Region: HTH_33; pfam13592
696747004622	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747004623	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747004624	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
696747004625	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
696747004626	NADP-binding site; other site
696747004627	homotetramer interface [polypeptide binding]; other site
696747004628	substrate binding site [chemical binding]; other site
696747004629	homodimer interface [polypeptide binding]; other site
696747004630	active site
696747004631	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
696747004632	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
696747004633	PhoH-like protein; Region: PhoH; pfam02562
696747004634	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
696747004635	KH domain; Region: KH_4; pfam13083
696747004636	ribosomal protein S16; Region: rps16; CHL00005
696747004637	signal recognition particle protein; Provisional; Region: PRK10867
696747004638	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
696747004639	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
696747004640	P loop; other site
696747004641	GTP binding site [chemical binding]; other site
696747004642	Signal peptide binding domain; Region: SRP_SPB; pfam02978
696747004643	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747004644	YacP-like NYN domain; Region: NYN_YacP; pfam05991
696747004645	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
696747004646	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
696747004647	Walker A/P-loop; other site
696747004648	ATP binding site [chemical binding]; other site
696747004649	Q-loop/lid; other site
696747004650	ABC transporter signature motif; other site
696747004651	Walker B; other site
696747004652	D-loop; other site
696747004653	H-loop/switch region; other site
696747004654	hypothetical protein; Provisional; Region: PRK13683
696747004655	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
696747004656	D1 interface; other site
696747004657	chlorophyll binding site; other site
696747004658	pheophytin binding site; other site
696747004659	beta carotene binding site; other site
696747004660	cytochrome b559 beta interface; other site
696747004661	quinone binding site; other site
696747004662	cytochrome b559 alpha interface; other site
696747004663	protein J interface; other site
696747004664	protein H interface; other site
696747004665	protein X interface; other site
696747004666	core light harvesting protein interface; other site
696747004667	protein L interface; other site
696747004668	CP43 interface; other site
696747004669	protein T interface; other site
696747004670	Fe binding site [ion binding]; other site
696747004671	protein M interface; other site
696747004672	Mn-stabilizing polypeptide interface; other site
696747004673	bromide binding site; other site
696747004674	cytochrome c-550 interface; other site
696747004675	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
696747004676	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747004677	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747004678	Probable transposase; Region: OrfB_IS605; pfam01385
696747004679	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747004680	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
696747004681	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004682	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004683	binding surface
696747004684	TPR motif; other site
696747004685	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004686	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004687	TPR motif; other site
696747004688	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004689	binding surface
696747004690	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004692	binding surface
696747004693	TPR motif; other site
696747004694	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004695	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004696	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004697	binding surface
696747004698	TPR motif; other site
696747004699	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004700	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004701	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004702	binding surface
696747004703	TPR motif; other site
696747004704	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004705	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004706	binding surface
696747004707	TPR motif; other site
696747004708	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004709	CHAT domain; Region: CHAT; pfam12770
696747004710	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
696747004711	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
696747004712	FOG: CBS domain [General function prediction only]; Region: COG0517
696747004713	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747004714	HEAT repeats; Region: HEAT_2; pfam13646
696747004715	HEAT repeats; Region: HEAT_2; pfam13646
696747004716	HEAT repeats; Region: HEAT_2; pfam13646
696747004717	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
696747004718	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
696747004719	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
696747004720	homopentamer interface [polypeptide binding]; other site
696747004721	active site
696747004722	Phospholipid methyltransferase; Region: PEMT; cl17370
696747004723	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
696747004724	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
696747004725	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
696747004726	Nucleoside recognition; Region: Gate; pfam07670
696747004727	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
696747004728	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
696747004729	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
696747004730	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
696747004731	active site
696747004732	HIGH motif; other site
696747004733	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
696747004734	KMSKS motif; other site
696747004735	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
696747004736	tRNA binding surface [nucleotide binding]; other site
696747004737	anticodon binding site; other site
696747004738	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
696747004739	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
696747004740	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
696747004741	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
696747004742	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
696747004743	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
696747004744	dimer interface [polypeptide binding]; other site
696747004745	active site
696747004746	aspartate-rich active site metal binding site; other site
696747004747	allosteric magnesium binding site [ion binding]; other site
696747004748	Schiff base residues; other site
696747004749	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747004750	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747004751	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747004752	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
696747004753	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
696747004754	active site
696747004755	catalytic triad [active]
696747004756	oxyanion hole [active]
696747004757	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
696747004758	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
696747004759	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
696747004760	putative active site [active]
696747004761	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
696747004762	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
696747004763	active site
696747004764	dimer interface [polypeptide binding]; other site
696747004765	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004766	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747004767	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004768	putative active site [active]
696747004769	putative NTP binding site [chemical binding]; other site
696747004770	putative nucleic acid binding site [nucleotide binding]; other site
696747004771	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747004772	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
696747004773	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
696747004774	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004775	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004776	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747004777	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
696747004778	recombinase A; Provisional; Region: recA; PRK09354
696747004779	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
696747004780	hexamer interface [polypeptide binding]; other site
696747004781	Walker A motif; other site
696747004782	ATP binding site [chemical binding]; other site
696747004783	Walker B motif; other site
696747004784	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
696747004785	isocitrate dehydrogenase; Validated; Region: PRK07362
696747004786	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
696747004787	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
696747004788	active site
696747004789	substrate-binding site [chemical binding]; other site
696747004790	metal-binding site [ion binding]
696747004791	ATP binding site [chemical binding]; other site
696747004792	Response regulator receiver domain; Region: Response_reg; pfam00072
696747004793	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747004794	active site
696747004795	phosphorylation site [posttranslational modification]
696747004796	intermolecular recognition site; other site
696747004797	dimerization interface [polypeptide binding]; other site
696747004798	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696747004799	DNA binding residues [nucleotide binding]
696747004800	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
696747004801	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
696747004802	dimer interface [polypeptide binding]; other site
696747004803	putative functional site; other site
696747004804	putative MPT binding site; other site
696747004805	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
696747004806	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
696747004807	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
696747004808	homodimer interface [polypeptide binding]; other site
696747004809	Walker A motif; other site
696747004810	ATP binding site [chemical binding]; other site
696747004811	hydroxycobalamin binding site [chemical binding]; other site
696747004812	Walker B motif; other site
696747004813	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696747004814	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
696747004815	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
696747004816	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747004817	FOG: CBS domain [General function prediction only]; Region: COG0517
696747004818	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747004819	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
696747004820	FOG: CBS domain [General function prediction only]; Region: COG0517
696747004821	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
696747004822	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747004823	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747004824	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747004825	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747004826	putative active site [active]
696747004827	heme pocket [chemical binding]; other site
696747004828	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747004829	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747004830	putative active site [active]
696747004831	heme pocket [chemical binding]; other site
696747004832	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747004833	putative active site [active]
696747004834	heme pocket [chemical binding]; other site
696747004835	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747004836	PAS domain; Region: PAS_9; pfam13426
696747004837	putative active site [active]
696747004838	heme pocket [chemical binding]; other site
696747004839	GAF domain; Region: GAF_2; pfam13185
696747004840	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
696747004841	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747004842	putative active site [active]
696747004843	heme pocket [chemical binding]; other site
696747004844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747004845	dimer interface [polypeptide binding]; other site
696747004846	phosphorylation site [posttranslational modification]
696747004847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747004848	ATP binding site [chemical binding]; other site
696747004849	Mg2+ binding site [ion binding]; other site
696747004850	G-X-G motif; other site
696747004851	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747004852	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747004853	active site
696747004854	phosphorylation site [posttranslational modification]
696747004855	intermolecular recognition site; other site
696747004856	dimerization interface [polypeptide binding]; other site
696747004857	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
696747004858	conserved hypothetical protein; Region: TIGR03492
696747004859	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
696747004860	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
696747004861	NAD binding site [chemical binding]; other site
696747004862	homodimer interface [polypeptide binding]; other site
696747004863	active site
696747004864	substrate binding site [chemical binding]; other site
696747004865	V-type ATP synthase subunit I; Validated; Region: PRK05771
696747004866	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
696747004867	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
696747004868	Fasciclin domain; Region: Fasciclin; pfam02469
696747004869	Domain of unknown function DUF29; Region: DUF29; pfam01724
696747004870	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
696747004871	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
696747004872	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
696747004873	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
696747004874	glutamine binding [chemical binding]; other site
696747004875	catalytic triad [active]
696747004876	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
696747004877	metal-binding heat shock protein; Provisional; Region: PRK00016
696747004878	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
696747004879	Caspase domain; Region: Peptidase_C14; pfam00656
696747004880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004881	binding surface
696747004882	TPR motif; other site
696747004883	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004884	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004885	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004886	binding surface
696747004887	TPR motif; other site
696747004888	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004889	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004890	binding surface
696747004891	TPR motif; other site
696747004892	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004893	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004894	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004895	binding surface
696747004896	TPR motif; other site
696747004897	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004898	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004899	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004900	binding surface
696747004901	TPR motif; other site
696747004902	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004903	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004904	CHAT domain; Region: CHAT; pfam12770
696747004905	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747004906	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747004907	Probable transposase; Region: OrfB_IS605; pfam01385
696747004908	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747004909	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747004910	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004911	putative active site [active]
696747004912	putative NTP binding site [chemical binding]; other site
696747004913	putative nucleic acid binding site [nucleotide binding]; other site
696747004914	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747004915	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747004916	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747004917	active site
696747004918	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004919	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
696747004920	Domain of unknown function (DUF927); Region: DUF927; cl12098
696747004921	Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
696747004922	Protein of unknown function (DUF1347); Region: DUF1347; pfam07079
696747004923	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
696747004924	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
696747004925	active site
696747004926	NTP binding site [chemical binding]; other site
696747004927	metal binding triad [ion binding]; metal-binding site
696747004928	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
696747004929	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
696747004930	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004931	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747004932	putative active site [active]
696747004933	putative nucleic acid binding site [nucleotide binding]; other site
696747004934	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747004935	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747004936	NTP binding site [chemical binding]; other site
696747004937	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004938	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004939	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004940	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747004941	putative active site [active]
696747004942	putative nucleic acid binding site [nucleotide binding]; other site
696747004943	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747004944	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747004945	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747004946	active site
696747004947	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747004948	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747004949	putative NTP binding site [chemical binding]; other site
696747004950	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747004951	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747004952	Homeodomain-like domain; Region: HTH_23; pfam13384
696747004953	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747004954	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747004955	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747004956	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747004957	metal binding site [ion binding]; metal-binding site
696747004958	active site
696747004959	I-site; other site
696747004960	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
696747004961	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747004962	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747004963	active site
696747004964	ATP binding site [chemical binding]; other site
696747004965	substrate binding site [chemical binding]; other site
696747004966	activation loop (A-loop); other site
696747004967	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747004968	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747004969	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747004970	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004971	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004972	TPR motif; other site
696747004973	binding surface
696747004974	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004975	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004976	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004977	binding surface
696747004978	TPR motif; other site
696747004979	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004980	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004981	Tetratricopeptide repeat; Region: TPR_10; pfam13374
696747004982	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004983	binding surface
696747004984	TPR motif; other site
696747004985	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004986	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004987	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004988	binding surface
696747004989	TPR motif; other site
696747004990	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004991	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004992	Tetratricopeptide repeat; Region: TPR_10; pfam13374
696747004993	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004994	binding surface
696747004995	TPR motif; other site
696747004996	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004997	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747004998	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747004999	binding surface
696747005000	TPR motif; other site
696747005001	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747005002	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747005003	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747005004	binding surface
696747005005	TPR motif; other site
696747005006	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747005007	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747005008	binding surface
696747005009	TPR motif; other site
696747005010	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747005011	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747005012	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747005013	binding surface
696747005014	TPR motif; other site
696747005015	CHAT domain; Region: CHAT; pfam12770
696747005016	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747005017	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747005018	TPR motif; other site
696747005019	binding surface
696747005020	TPR repeat; Region: TPR_11; pfam13414
696747005021	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747005022	CHAT domain; Region: CHAT; pfam12770
696747005023	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747005024	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747005025	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747005026	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747005027	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
696747005028	Glycoprotease family; Region: Peptidase_M22; pfam00814
696747005029	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
696747005030	cobalt transport protein CbiM; Validated; Region: PRK06265
696747005031	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
696747005032	nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890
696747005033	Ferritin-like domain; Region: Ferritin; pfam00210
696747005034	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
696747005035	dinuclear metal binding motif [ion binding]; other site
696747005036	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747005037	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
696747005038	putative active site [active]
696747005039	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
696747005040	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
696747005041	Fasciclin domain; Region: Fasciclin; pfam02469
696747005042	Circadian oscillating protein COP23; Region: COP23; pfam14218
696747005043	Phycobilisome protein; Region: Phycobilisome; cl08227
696747005044	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
696747005045	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
696747005046	ATP-grasp domain; Region: ATP-grasp_4; cl17255
696747005047	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
696747005048	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
696747005049	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
696747005050	proposed catalytic triad [active]
696747005051	active site nucleophile [active]
696747005052	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
696747005053	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
696747005054	catalytic residues [active]
696747005055	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
696747005056	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
696747005057	active site
696747005058	homodimer interface [polypeptide binding]; other site
696747005059	catalytic site [active]
696747005060	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
696747005061	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
696747005062	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
696747005063	Ligand Binding Site [chemical binding]; other site
696747005064	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696747005065	Ligand Binding Site [chemical binding]; other site
696747005066	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005067	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005068	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005069	putative NTP binding site [chemical binding]; other site
696747005070	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005071	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747005072	putative active site [active]
696747005073	putative nucleic acid binding site [nucleotide binding]; other site
696747005074	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747005075	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747005076	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747005077	active site
696747005078	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747005079	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747005080	Winged helix-turn helix; Region: HTH_29; pfam13551
696747005081	Homeodomain-like domain; Region: HTH_23; cl17451
696747005082	Homeodomain-like domain; Region: HTH_32; pfam13565
696747005083	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747005084	Winged helix-turn helix; Region: HTH_29; pfam13551
696747005085	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747005086	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747005087	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747005088	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747005089	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
696747005090	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
696747005091	DNA photolyase; Region: DNA_photolyase; pfam00875
696747005092	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
696747005093	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
696747005094	CoA binding domain; Region: CoA_binding; smart00881
696747005095	CoA-ligase; Region: Ligase_CoA; pfam00549
696747005096	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
696747005097	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
696747005098	CoA-ligase; Region: Ligase_CoA; pfam00549
696747005099	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747005100	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
696747005101	DXD motif; other site
696747005102	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
696747005103	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696747005104	DRTGG domain; Region: DRTGG; pfam07085
696747005105	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
696747005106	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
696747005107	HicB family; Region: HicB; pfam05534
696747005108	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696747005109	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696747005110	MarR family; Region: MarR_2; cl17246
696747005111	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
696747005112	active site
696747005113	catalytic residues [active]
696747005114	DNA binding site [nucleotide binding]
696747005115	Int/Topo IB signature motif; other site
696747005116	Class I aldolases; Region: Aldolase_Class_I; cl17187
696747005117	AAA domain; Region: AAA_11; pfam13086
696747005118	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747005119	Walker A motif; other site
696747005120	ATP binding site [chemical binding]; other site
696747005121	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
696747005122	AAA domain; Region: AAA_12; pfam13087
696747005123	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
696747005124	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696747005125	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
696747005126	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696747005127	DNA binding residues [nucleotide binding]
696747005128	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
696747005129	lipoyl attachment site [posttranslational modification]; other site
696747005130	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
696747005131	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
696747005132	Bacterial SH3 domain; Region: SH3_3; pfam08239
696747005133	Cupin-like domain; Region: Cupin_8; pfam13621
696747005134	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
696747005135	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
696747005136	putative active site [active]
696747005137	putative dimer interface [polypeptide binding]; other site
696747005138	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
696747005139	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
696747005140	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
696747005141	photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056
696747005142	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
696747005143	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
696747005144	Lumazine binding domain; Region: Lum_binding; pfam00677
696747005145	Lumazine binding domain; Region: Lum_binding; pfam00677
696747005146	Bifunctional nuclease; Region: DNase-RNase; pfam02577
696747005147	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
696747005148	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
696747005149	active site
696747005150	catalytic tetrad [active]
696747005151	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
696747005152	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
696747005153	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
696747005154	putative ligand binding site [chemical binding]; other site
696747005155	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747005156	active site
696747005157	ATP binding site [chemical binding]; other site
696747005158	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747005159	substrate binding site [chemical binding]; other site
696747005160	activation loop (A-loop); other site
696747005161	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
696747005162	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
696747005163	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
696747005164	putative dimerization interface [polypeptide binding]; other site
696747005165	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
696747005166	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
696747005167	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
696747005168	putative dimerization interface [polypeptide binding]; other site
696747005169	Predicted membrane protein [Function unknown]; Region: COG4094
696747005170	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
696747005171	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
696747005172	catalytic residues [active]
696747005173	Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976
696747005174	NodB motif; other site
696747005175	putative active site [active]
696747005176	putative catalytic site [active]
696747005177	Class I aldolases; Region: Aldolase_Class_I; cl17187
696747005178	catalytic residue [active]
696747005179	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
696747005180	transketolase; Region: PLN02790
696747005181	TPP-binding site [chemical binding]; other site
696747005182	dimer interface [polypeptide binding]; other site
696747005183	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
696747005184	PYR/PP interface [polypeptide binding]; other site
696747005185	dimer interface [polypeptide binding]; other site
696747005186	TPP binding site [chemical binding]; other site
696747005187	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
696747005188	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
696747005189	RNA/DNA hybrid binding site [nucleotide binding]; other site
696747005190	active site
696747005191	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
696747005192	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
696747005193	purine monophosphate binding site [chemical binding]; other site
696747005194	dimer interface [polypeptide binding]; other site
696747005195	putative catalytic residues [active]
696747005196	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
696747005197	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
696747005198	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
696747005199	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
696747005200	Ycf27; Reviewed; Region: orf27; CHL00148
696747005201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747005202	active site
696747005203	phosphorylation site [posttranslational modification]
696747005204	intermolecular recognition site; other site
696747005205	dimerization interface [polypeptide binding]; other site
696747005206	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747005207	DNA binding site [nucleotide binding]
696747005208	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
696747005209	transmembrane helices; other site
696747005210	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
696747005211	TrkA-C domain; Region: TrkA_C; pfam02080
696747005212	TrkA-C domain; Region: TrkA_C; pfam02080
696747005213	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
696747005214	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
696747005215	elongation factor G; Reviewed; Region: PRK12740
696747005216	G1 box; other site
696747005217	putative GEF interaction site [polypeptide binding]; other site
696747005218	GTP/Mg2+ binding site [chemical binding]; other site
696747005219	Switch I region; other site
696747005220	G2 box; other site
696747005221	G3 box; other site
696747005222	Switch II region; other site
696747005223	G4 box; other site
696747005224	G5 box; other site
696747005225	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
696747005226	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
696747005227	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
696747005228	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
696747005229	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
696747005230	PYR/PP interface [polypeptide binding]; other site
696747005231	dimer interface [polypeptide binding]; other site
696747005232	TPP binding site [chemical binding]; other site
696747005233	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
696747005234	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
696747005235	TPP-binding site [chemical binding]; other site
696747005236	dimer interface [polypeptide binding]; other site
696747005237	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
696747005238	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
696747005239	active site
696747005240	catalytic residues [active]
696747005241	metal binding site [ion binding]; metal-binding site
696747005242	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
696747005243	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
696747005244	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
696747005245	Ligand binding site; other site
696747005246	Putative Catalytic site; other site
696747005247	DXD motif; other site
696747005248	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
696747005249	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747005250	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747005251	Cupin superfamily protein; Region: Cupin_4; pfam08007
696747005252	Cupin-like domain; Region: Cupin_8; pfam13621
696747005253	OB-fold nucleic acid binding domain; Region: tRNA_anti; pfam01336
696747005254	generic binding surface II; other site
696747005255	generic binding surface I; other site
696747005256	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696747005257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747005258	active site
696747005259	phosphorylation site [posttranslational modification]
696747005260	intermolecular recognition site; other site
696747005261	dimerization interface [polypeptide binding]; other site
696747005262	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747005263	DNA binding site [nucleotide binding]
696747005264	CHASE3 domain; Region: CHASE3; pfam05227
696747005265	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747005266	dimer interface [polypeptide binding]; other site
696747005267	phosphorylation site [posttranslational modification]
696747005268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747005269	ATP binding site [chemical binding]; other site
696747005270	Mg2+ binding site [ion binding]; other site
696747005271	G-X-G motif; other site
696747005272	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
696747005273	Uncharacterized conserved protein [Function unknown]; Region: COG1359
696747005274	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
696747005275	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
696747005276	ribosomal protein L23; Region: rpl23; CHL00030
696747005277	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
696747005278	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
696747005279	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
696747005280	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
696747005281	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
696747005282	putative translocon binding site; other site
696747005283	protein-rRNA interface [nucleotide binding]; other site
696747005284	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
696747005285	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
696747005286	G-X-X-G motif; other site
696747005287	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
696747005288	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
696747005289	23S rRNA interface [nucleotide binding]; other site
696747005290	5S rRNA interface [nucleotide binding]; other site
696747005291	putative antibiotic binding site [chemical binding]; other site
696747005292	L25 interface [polypeptide binding]; other site
696747005293	L27 interface [polypeptide binding]; other site
696747005294	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
696747005295	putative translocon interaction site; other site
696747005296	23S rRNA interface [nucleotide binding]; other site
696747005297	signal recognition particle (SRP54) interaction site; other site
696747005298	L23 interface [polypeptide binding]; other site
696747005299	trigger factor interaction site; other site
696747005300	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
696747005301	ribosomal protein L14; Region: rpl14; CHL00057
696747005302	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
696747005303	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
696747005304	RNA binding site [nucleotide binding]; other site
696747005305	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
696747005306	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
696747005307	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
696747005308	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
696747005309	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
696747005310	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
696747005311	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
696747005312	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
696747005313	23S rRNA interface [nucleotide binding]; other site
696747005314	5S rRNA interface [nucleotide binding]; other site
696747005315	L27 interface [polypeptide binding]; other site
696747005316	L5 interface [polypeptide binding]; other site
696747005317	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
696747005318	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
696747005319	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
696747005320	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
696747005321	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
696747005322	SecY translocase; Region: SecY; pfam00344
696747005323	adenylate kinase; Provisional; Region: adk; PRK02496
696747005324	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
696747005325	AMP-binding site [chemical binding]; other site
696747005326	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
696747005327	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
696747005328	rRNA binding site [nucleotide binding]; other site
696747005329	predicted 30S ribosome binding site; other site
696747005330	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
696747005331	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
696747005332	30S ribosomal protein S13; Region: bact_S13; TIGR03631
696747005333	30S ribosomal protein S11; Validated; Region: PRK05309
696747005334	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
696747005335	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
696747005336	alphaNTD homodimer interface [polypeptide binding]; other site
696747005337	alphaNTD - beta interaction site [polypeptide binding]; other site
696747005338	alphaNTD - beta' interaction site [polypeptide binding]; other site
696747005339	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
696747005340	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
696747005341	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
696747005342	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
696747005343	dimerization interface 3.5A [polypeptide binding]; other site
696747005344	active site
696747005345	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
696747005346	23S rRNA interface [nucleotide binding]; other site
696747005347	L3 interface [polypeptide binding]; other site
696747005348	ribosomal protein S9; Region: rps9; CHL00079
696747005349	ribosomal protein L31; Validated; Region: rpl31; CHL00136
696747005350	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747005351	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747005352	Probable transposase; Region: OrfB_IS605; pfam01385
696747005353	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747005354	peptide chain release factor 1; Validated; Region: prfA; PRK00591
696747005355	This domain is found in peptide chain release factors; Region: PCRF; smart00937
696747005356	RF-1 domain; Region: RF-1; pfam00472
696747005357	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747005358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747005359	active site
696747005360	phosphorylation site [posttranslational modification]
696747005361	intermolecular recognition site; other site
696747005362	dimerization interface [polypeptide binding]; other site
696747005363	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
696747005364	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696747005365	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696747005366	ABC transporter; Region: ABC_tran_2; pfam12848
696747005367	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696747005368	Response regulator receiver domain; Region: Response_reg; pfam00072
696747005369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747005370	active site
696747005371	phosphorylation site [posttranslational modification]
696747005372	intermolecular recognition site; other site
696747005373	dimerization interface [polypeptide binding]; other site
696747005374	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
696747005375	Calx-beta domain; Region: Calx-beta; pfam03160
696747005376	Calx-beta domain; Region: Calx-beta; cl02522
696747005377	Calx-beta domain; Region: Calx-beta; pfam03160
696747005378	chaperone protein DnaJ; Provisional; Region: PRK14299
696747005379	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
696747005380	HSP70 interaction site [polypeptide binding]; other site
696747005381	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
696747005382	substrate binding site [polypeptide binding]; other site
696747005383	dimer interface [polypeptide binding]; other site
696747005384	AAA domain; Region: AAA_33; pfam13671
696747005385	AAA domain; Region: AAA_17; pfam13207
696747005386	L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575
696747005387	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
696747005388	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
696747005389	ligand binding site; other site
696747005390	oligomer interface; other site
696747005391	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696747005392	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
696747005393	dimer interface [polypeptide binding]; other site
696747005394	N-terminal domain interface [polypeptide binding]; other site
696747005395	sulfate 1 binding site; other site
696747005396	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
696747005397	Bacterial SH3 domain; Region: SH3_3; pfam08239
696747005398	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696747005399	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747005400	S-adenosylmethionine binding site [chemical binding]; other site
696747005401	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
696747005402	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
696747005403	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
696747005404	catalytic motif [active]
696747005405	Zn binding site [ion binding]; other site
696747005406	RibD C-terminal domain; Region: RibD_C; cl17279
696747005407	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
696747005408	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
696747005409	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696747005410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696747005411	putative substrate translocation pore; other site
696747005412	Yip1 domain; Region: Yip1; pfam04893
696747005413	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
696747005414	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747005415	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747005416	Calx-beta domain; Region: Calx-beta; cl02522
696747005417	Calx-beta domain; Region: Calx-beta; pfam03160
696747005418	Calx-beta domain; Region: Calx-beta; cl02522
696747005419	Calx-beta domain; Region: Calx-beta; pfam03160
696747005420	Calx-beta domain; Region: Calx-beta; cl02522
696747005421	Calx-beta domain; Region: Calx-beta; pfam03160
696747005422	Calx-beta domain; Region: Calx-beta; pfam03160
696747005423	Calx-beta domain; Region: Calx-beta; pfam03160
696747005424	Calx-beta domain; Region: Calx-beta; cl02522
696747005425	Calx-beta domain; Region: Calx-beta; pfam03160
696747005426	Calx-beta domain; Region: Calx-beta; cl02522
696747005427	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747005428	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
696747005429	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
696747005430	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
696747005431	Family description; Region: VCBS; pfam13517
696747005432	Family description; Region: VCBS; pfam13517
696747005433	Family description; Region: VCBS; pfam13517
696747005434	Family description; Region: VCBS; pfam13517
696747005435	Family description; Region: VCBS; pfam13517
696747005436	Family description; Region: VCBS; pfam13517
696747005437	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747005438	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747005439	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
696747005440	Predicted permeases [General function prediction only]; Region: COG0679
696747005441	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696747005442	extended (e) SDRs; Region: SDR_e; cd08946
696747005443	NAD(P) binding site [chemical binding]; other site
696747005444	active site
696747005445	substrate binding site [chemical binding]; other site
696747005446	Predicted membrane protein [Function unknown]; Region: COG3431
696747005447	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
696747005448	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747005449	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747005450	dimerization interface [polypeptide binding]; other site
696747005451	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
696747005452	PAS domain; Region: PAS; smart00091
696747005453	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747005454	dimer interface [polypeptide binding]; other site
696747005455	phosphorylation site [posttranslational modification]
696747005456	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747005457	ATP binding site [chemical binding]; other site
696747005458	Mg2+ binding site [ion binding]; other site
696747005459	G-X-G motif; other site
696747005460	Response regulator receiver domain; Region: Response_reg; pfam00072
696747005461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747005462	active site
696747005463	phosphorylation site [posttranslational modification]
696747005464	intermolecular recognition site; other site
696747005465	dimerization interface [polypeptide binding]; other site
696747005466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747005467	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747005468	GAF domain; Region: GAF_3; pfam13492
696747005469	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747005470	cyclase homology domain; Region: CHD; cd07302
696747005471	nucleotidyl binding site; other site
696747005472	metal binding site [ion binding]; metal-binding site
696747005473	dimer interface [polypeptide binding]; other site
696747005474	Response regulator receiver domain; Region: Response_reg; pfam00072
696747005475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747005476	active site
696747005477	phosphorylation site [posttranslational modification]
696747005478	intermolecular recognition site; other site
696747005479	dimerization interface [polypeptide binding]; other site
696747005480	ABC1 family; Region: ABC1; cl17513
696747005481	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
696747005482	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
696747005483	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
696747005484	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
696747005485	Walker A/P-loop; other site
696747005486	ATP binding site [chemical binding]; other site
696747005487	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
696747005488	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
696747005489	ABC transporter signature motif; other site
696747005490	Walker B; other site
696747005491	D-loop; other site
696747005492	H-loop/switch region; other site
696747005493	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
696747005494	ABC transporter signature motif; other site
696747005495	Walker B; other site
696747005496	D-loop; other site
696747005497	H-loop/switch region; other site
696747005498	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
696747005499	PRC-barrel domain; Region: PRC; pfam05239
696747005500	photosystem II reaction center protein Psb28; Provisional; Region: PRK13612
696747005501	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
696747005502	active site
696747005503	ribulose/triose binding site [chemical binding]; other site
696747005504	phosphate binding site [ion binding]; other site
696747005505	substrate (anthranilate) binding pocket [chemical binding]; other site
696747005506	product (indole) binding pocket [chemical binding]; other site
696747005507	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
696747005508	homodimer interface [polypeptide binding]; other site
696747005509	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747005510	catalytic residue [active]
696747005511	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
696747005512	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
696747005513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747005514	S-adenosylmethionine binding site [chemical binding]; other site
696747005515	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
696747005516	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
696747005517	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
696747005518	enolase; Provisional; Region: eno; PRK00077
696747005519	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
696747005520	dimer interface [polypeptide binding]; other site
696747005521	metal binding site [ion binding]; metal-binding site
696747005522	substrate binding pocket [chemical binding]; other site
696747005523	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
696747005524	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
696747005525	putative ligand binding site [chemical binding]; other site
696747005526	putative NAD binding site [chemical binding]; other site
696747005527	catalytic site [active]
696747005528	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
696747005529	TPR repeat; Region: TPR_11; pfam13414
696747005530	TPR repeat; Region: TPR_11; pfam13414
696747005531	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747005532	binding surface
696747005533	TPR motif; other site
696747005534	TPR repeat; Region: TPR_11; pfam13414
696747005535	Tetratricopeptide repeat; Region: TPR_1; pfam00515
696747005536	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
696747005537	RimM N-terminal domain; Region: RimM; pfam01782
696747005538	PRC-barrel domain; Region: PRC; pfam05239
696747005539	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696747005540	sequence-specific DNA binding site [nucleotide binding]; other site
696747005541	salt bridge; other site
696747005542	Outer membrane efflux protein; Region: OEP; pfam02321
696747005543	Outer membrane efflux protein; Region: OEP; pfam02321
696747005544	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
696747005545	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696747005546	catalytic loop [active]
696747005547	iron binding site [ion binding]; other site
696747005548	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696747005549	Ligand Binding Site [chemical binding]; other site
696747005550	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
696747005551	active site
696747005552	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
696747005553	glutaminase; Provisional; Region: PRK00971
696747005554	TPR repeat; Region: TPR_11; pfam13414
696747005555	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747005556	binding surface
696747005557	TPR motif; other site
696747005558	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747005559	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747005560	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747005561	TPR motif; other site
696747005562	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747005563	binding surface
696747005564	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747005565	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747005566	binding surface
696747005567	TPR motif; other site
696747005568	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747005569	CHAT domain; Region: CHAT; pfam12770
696747005570	FecR protein; Region: FecR; pfam04773
696747005571	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
696747005572	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
696747005573	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
696747005574	inhibitor binding site; inhibition site
696747005575	catalytic motif [active]
696747005576	Catalytic residue [active]
696747005577	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
696747005578	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
696747005579	NB-ARC domain; Region: NB-ARC; pfam00931
696747005580	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747005581	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747005582	structural tetrad; other site
696747005583	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747005584	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747005585	structural tetrad; other site
696747005586	WD40 repeats; Region: WD40; smart00320
696747005587	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
696747005588	putative active site [active]
696747005589	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
696747005590	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
696747005591	WD40 repeats; Region: WD40; smart00320
696747005592	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747005593	WD domain, G-beta repeat; Region: WD40; pfam00400
696747005594	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747005595	structural tetrad; other site
696747005596	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747005597	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747005598	structural tetrad; other site
696747005599	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
696747005600	Fasciclin domain; Region: Fasciclin; pfam02469
696747005601	Permease; Region: Permease; cl00510
696747005602	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
696747005603	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
696747005604	V4R domain; Region: V4R; pfam02830
696747005605	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
696747005606	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
696747005607	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747005608	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747005609	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747005610	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747005611	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747005612	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747005613	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747005614	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747005615	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747005616	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747005617	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747005618	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
696747005619	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696747005620	catalytic loop [active]
696747005621	iron binding site [ion binding]; other site
696747005622	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747005623	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747005624	active site
696747005625	ATP binding site [chemical binding]; other site
696747005626	substrate binding site [chemical binding]; other site
696747005627	activation loop (A-loop); other site
696747005628	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
696747005629	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005630	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005631	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747005632	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005633	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747005634	putative nucleic acid binding site [nucleotide binding]; other site
696747005635	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747005636	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747005637	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747005638	active site
696747005639	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
696747005640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
696747005641	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
696747005642	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005643	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747005644	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005645	putative NTP binding site [chemical binding]; other site
696747005646	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005647	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747005648	putative active site [active]
696747005649	putative nucleic acid binding site [nucleotide binding]; other site
696747005650	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747005651	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747005652	active site
696747005653	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005654	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747005655	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005656	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005657	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005658	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005659	putative NTP binding site [chemical binding]; other site
696747005660	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005661	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747005662	putative active site [active]
696747005663	putative nucleic acid binding site [nucleotide binding]; other site
696747005664	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747005665	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747005666	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747005667	active site
696747005668	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005669	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747005670	putative active site [active]
696747005671	putative nucleic acid binding site [nucleotide binding]; other site
696747005672	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747005673	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747005674	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747005675	active site
696747005676	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
696747005677	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005678	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005679	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747005680	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005681	putative active site [active]
696747005682	putative NTP binding site [chemical binding]; other site
696747005683	putative nucleic acid binding site [nucleotide binding]; other site
696747005684	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747005685	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747005686	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747005687	active site
696747005688	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005689	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747005690	putative active site [active]
696747005691	putative nucleic acid binding site [nucleotide binding]; other site
696747005692	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747005693	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747005694	active site
696747005695	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005696	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747005697	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005698	putative NTP binding site [chemical binding]; other site
696747005699	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747005700	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747005701	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
696747005702	Helix-turn-helix domain; Region: HTH_28; pfam13518
696747005703	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747005704	Switch II region; other site
696747005705	Phage tail repeat like; Region: PTR; pfam12789
696747005706	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747005707	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696747005708	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696747005709	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
696747005710	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
696747005711	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
696747005712	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
696747005713	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
696747005714	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
696747005715	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
696747005716	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
696747005717	Probable transposase; Region: OrfB_IS605; pfam01385
696747005718	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747005719	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747005720	spermidine synthase; Provisional; Region: PRK00811
696747005721	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747005722	S-adenosylmethionine binding site [chemical binding]; other site
696747005723	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
696747005724	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
696747005725	homodimer interface [polypeptide binding]; other site
696747005726	substrate-cofactor binding pocket; other site
696747005727	catalytic residue [active]
696747005728	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
696747005729	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
696747005730	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
696747005731	Sm and related proteins; Region: Sm_like; cl00259
696747005732	heptamer interface [polypeptide binding]; other site
696747005733	Sm1 motif; other site
696747005734	hexamer interface [polypeptide binding]; other site
696747005735	RNA binding site [nucleotide binding]; other site
696747005736	Sm2 motif; other site
696747005737	Cache domain; Region: Cache_1; pfam02743
696747005738	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747005739	dimerization interface [polypeptide binding]; other site
696747005740	PAS domain S-box; Region: sensory_box; TIGR00229
696747005741	PAS domain S-box; Region: sensory_box; TIGR00229
696747005742	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747005743	putative active site [active]
696747005744	heme pocket [chemical binding]; other site
696747005745	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
696747005746	glutaminase A; Region: Gln_ase; TIGR03814
696747005747	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
696747005748	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747005749	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747005750	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747005751	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005752	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005753	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005754	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005755	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005756	putative NTP binding site [chemical binding]; other site
696747005757	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005758	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747005759	putative active site [active]
696747005760	putative nucleic acid binding site [nucleotide binding]; other site
696747005761	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747005762	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747005763	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747005764	active site
696747005765	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747005766	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747005767	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747005768	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747005769	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747005770	active site
696747005771	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
696747005772	homooctamer interface [polypeptide binding]; other site
696747005773	active site
696747005774	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
696747005775	TPP-binding site [chemical binding]; other site
696747005776	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
696747005777	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
696747005778	PYR/PP interface [polypeptide binding]; other site
696747005779	dimer interface [polypeptide binding]; other site
696747005780	TPP binding site [chemical binding]; other site
696747005781	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
696747005782	The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633
696747005783	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
696747005784	active site
696747005785	catalytic triad [active]
696747005786	oxyanion hole [active]
696747005787	Uncharacterized conserved protein [Function unknown]; Region: COG1479
696747005788	Protein of unknown function DUF262; Region: DUF262; pfam03235
696747005789	Predicted esterase [General function prediction only]; Region: COG0400
696747005790	putative hydrolase; Provisional; Region: PRK11460
696747005791	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
696747005792	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
696747005793	Flavoprotein; Region: Flavoprotein; pfam02441
696747005794	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
696747005795	geranylgeranyl reductase; Region: ChlP; TIGR02028
696747005796	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696747005797	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
696747005798	S-layer homology domain; Region: SLH; pfam00395
696747005799	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
696747005800	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
696747005801	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
696747005802	trimer interface [polypeptide binding]; other site
696747005803	active site
696747005804	substrate binding site [chemical binding]; other site
696747005805	CoA binding site [chemical binding]; other site
696747005806	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
696747005807	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
696747005808	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
696747005809	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
696747005810	Protein of unknown function (DUF1347); Region: DUF1347; pfam07079
696747005811	Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
696747005812	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005813	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747005814	putative active site [active]
696747005815	putative nucleic acid binding site [nucleotide binding]; other site
696747005816	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747005817	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747005818	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747005819	active site
696747005820	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005821	putative NTP binding site [chemical binding]; other site
696747005822	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005823	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005824	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
696747005825	Predicted helicase [General function prediction only]; Region: COG4889
696747005826	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
696747005827	Response regulator receiver domain; Region: Response_reg; pfam00072
696747005828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747005829	active site
696747005830	phosphorylation site [posttranslational modification]
696747005831	intermolecular recognition site; other site
696747005832	dimerization interface [polypeptide binding]; other site
696747005833	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747005834	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747005835	Response regulator receiver domain; Region: Response_reg; pfam00072
696747005836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747005837	active site
696747005838	phosphorylation site [posttranslational modification]
696747005839	intermolecular recognition site; other site
696747005840	dimerization interface [polypeptide binding]; other site
696747005841	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
696747005842	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747005843	dimerization interface [polypeptide binding]; other site
696747005844	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696747005845	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696747005846	dimer interface [polypeptide binding]; other site
696747005847	putative CheW interface [polypeptide binding]; other site
696747005848	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
696747005849	putative binding surface; other site
696747005850	active site
696747005851	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
696747005852	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
696747005853	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747005854	ATP binding site [chemical binding]; other site
696747005855	Mg2+ binding site [ion binding]; other site
696747005856	G-X-G motif; other site
696747005857	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
696747005858	Response regulator receiver domain; Region: Response_reg; pfam00072
696747005859	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747005860	active site
696747005861	phosphorylation site [posttranslational modification]
696747005862	intermolecular recognition site; other site
696747005863	dimerization interface [polypeptide binding]; other site
696747005864	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747005865	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747005866	Probable transposase; Region: OrfB_IS605; pfam01385
696747005867	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747005868	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747005869	Transposase IS200 like; Region: Y1_Tnp; pfam01797
696747005870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747005871	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
696747005872	Walker A motif; other site
696747005873	ATP binding site [chemical binding]; other site
696747005874	Walker B motif; other site
696747005875	arginine finger; other site
696747005876	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747005877	Walker A motif; other site
696747005878	ATP binding site [chemical binding]; other site
696747005879	Walker B motif; other site
696747005880	arginine finger; other site
696747005881	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747005882	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747005883	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005884	putative NTP binding site [chemical binding]; other site
696747005885	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747005886	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747005887	putative active site [active]
696747005888	putative nucleic acid binding site [nucleotide binding]; other site
696747005889	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747005890	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747005891	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747005892	active site
696747005893	Winged helix-turn helix; Region: HTH_29; pfam13551
696747005894	Homeodomain-like domain; Region: HTH_23; pfam13384
696747005895	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747005896	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747005897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747005898	intermolecular recognition site; other site
696747005899	active site
696747005900	dimerization interface [polypeptide binding]; other site
696747005901	FOG: CBS domain [General function prediction only]; Region: COG0517
696747005902	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747005903	FOG: CBS domain [General function prediction only]; Region: COG0517
696747005904	FOG: CBS domain [General function prediction only]; Region: COG0517
696747005905	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
696747005906	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747005907	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747005908	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747005909	PAS fold; Region: PAS_3; pfam08447
696747005910	putative active site [active]
696747005911	heme pocket [chemical binding]; other site
696747005912	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747005913	PAS fold; Region: PAS_3; pfam08447
696747005914	putative active site [active]
696747005915	heme pocket [chemical binding]; other site
696747005916	PAS domain S-box; Region: sensory_box; TIGR00229
696747005917	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747005918	putative active site [active]
696747005919	heme pocket [chemical binding]; other site
696747005920	PAS domain S-box; Region: sensory_box; TIGR00229
696747005921	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747005922	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747005923	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747005924	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747005925	metal binding site [ion binding]; metal-binding site
696747005926	active site
696747005927	I-site; other site
696747005928	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
696747005929	NlpC/P60 family; Region: NLPC_P60; pfam00877
696747005930	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
696747005931	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
696747005932	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
696747005933	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
696747005934	UbiA prenyltransferase family; Region: UbiA; pfam01040
696747005935	Maf-like protein; Region: Maf; pfam02545
696747005936	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
696747005937	active site
696747005938	dimer interface [polypeptide binding]; other site
696747005939	PsbP; Region: PsbP; pfam01789
696747005940	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696747005941	Peptidase family M23; Region: Peptidase_M23; pfam01551
696747005942	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747005943	Circadian oscillating protein COP23; Region: COP23; pfam14218
696747005944	Homeodomain-like domain; Region: HTH_23; pfam13384
696747005945	Winged helix-turn helix; Region: HTH_29; pfam13551
696747005946	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
696747005947	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
696747005948	mce related protein; Region: MCE; pfam02470
696747005949	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
696747005950	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
696747005951	Walker A/P-loop; other site
696747005952	ATP binding site [chemical binding]; other site
696747005953	Q-loop/lid; other site
696747005954	ABC transporter signature motif; other site
696747005955	Walker B; other site
696747005956	D-loop; other site
696747005957	H-loop/switch region; other site
696747005958	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
696747005959	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
696747005960	phosphate binding site [ion binding]; other site
696747005961	putative substrate binding pocket [chemical binding]; other site
696747005962	dimer interface [polypeptide binding]; other site
696747005963	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
696747005964	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747005965	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747005966	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
696747005967	putative active site [active]
696747005968	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747005969	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
696747005970	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747005971	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
696747005972	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747005973	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747005974	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
696747005975	putative active site [active]
696747005976	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
696747005977	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
696747005978	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
696747005979	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
696747005980	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
696747005981	dimer interface [polypeptide binding]; other site
696747005982	putative metal binding site [ion binding]; other site
696747005983	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
696747005984	Resolvase, N terminal domain; Region: Resolvase; smart00857
696747005985	Recombinase; Region: Recombinase; pfam07508
696747005986	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
696747005987	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
696747005988	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
696747005989	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
696747005990	cobyric acid synthase; Provisional; Region: PRK00784
696747005991	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
696747005992	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
696747005993	catalytic triad [active]
696747005994	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
696747005995	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
696747005996	catalytic triad [active]
696747005997	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
696747005998	putative active site [active]
696747005999	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
696747006000	H+ Antiporter protein; Region: 2A0121; TIGR00900
696747006001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696747006002	Preprotein translocase SecG subunit; Region: SecG; cl09123
696747006003	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
696747006004	active site
696747006005	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
696747006006	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
696747006007	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
696747006008	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
696747006009	active site
696747006010	metal binding site [ion binding]; metal-binding site
696747006011	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
696747006012	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
696747006013	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
696747006014	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
696747006015	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
696747006016	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
696747006017	NAD(P) binding site [chemical binding]; other site
696747006018	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
696747006019	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696747006020	catalytic loop [active]
696747006021	iron binding site [ion binding]; other site
696747006022	Staphylococcal nuclease homologues; Region: SNc; smart00318
696747006023	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
696747006024	Catalytic site; other site
696747006025	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
696747006026	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
696747006027	active site
696747006028	dimerization interface [polypeptide binding]; other site
696747006029	DnaJ domain; Region: DnaJ; pfam00226
696747006030	HSP70 interaction site [polypeptide binding]; other site
696747006031	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747006032	binding surface
696747006033	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747006034	TPR motif; other site
696747006035	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
696747006036	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
696747006037	dimer interface [polypeptide binding]; other site
696747006038	motif 1; other site
696747006039	active site
696747006040	motif 2; other site
696747006041	motif 3; other site
696747006042	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
696747006043	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696747006044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747006045	homodimer interface [polypeptide binding]; other site
696747006046	catalytic residue [active]
696747006047	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
696747006048	translation initiation factor IF-2; Region: IF-2; TIGR00487
696747006049	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
696747006050	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
696747006051	G1 box; other site
696747006052	putative GEF interaction site [polypeptide binding]; other site
696747006053	GTP/Mg2+ binding site [chemical binding]; other site
696747006054	Switch I region; other site
696747006055	G2 box; other site
696747006056	G3 box; other site
696747006057	Switch II region; other site
696747006058	G4 box; other site
696747006059	G5 box; other site
696747006060	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
696747006061	Translation-initiation factor 2; Region: IF-2; pfam11987
696747006062	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
696747006063	Protein of unknown function (DUF448); Region: DUF448; pfam04296
696747006064	putative RNA binding cleft [nucleotide binding]; other site
696747006065	NusA N-terminal domain; Region: NusA_N; pfam08529
696747006066	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
696747006067	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
696747006068	RNA binding site [nucleotide binding]; other site
696747006069	homodimer interface [polypeptide binding]; other site
696747006070	NusA-like KH domain; Region: KH_5; pfam13184
696747006071	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
696747006072	G-X-X-G motif; other site
696747006073	ribosome maturation protein RimP; Reviewed; Region: PRK00092
696747006074	Sm and related proteins; Region: Sm_like; cl00259
696747006075	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
696747006076	putative oligomer interface [polypeptide binding]; other site
696747006077	putative RNA binding site [nucleotide binding]; other site
696747006078	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696747006079	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747006080	active site
696747006081	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
696747006082	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
696747006083	PAS fold; Region: PAS_4; pfam08448
696747006084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747006085	PAS fold; Region: PAS_3; pfam08447
696747006086	putative active site [active]
696747006087	heme pocket [chemical binding]; other site
696747006088	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747006089	dimer interface [polypeptide binding]; other site
696747006090	phosphorylation site [posttranslational modification]
696747006091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747006092	ATP binding site [chemical binding]; other site
696747006093	Mg2+ binding site [ion binding]; other site
696747006094	G-X-G motif; other site
696747006095	Response regulator receiver domain; Region: Response_reg; pfam00072
696747006096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006097	active site
696747006098	phosphorylation site [posttranslational modification]
696747006099	intermolecular recognition site; other site
696747006100	dimerization interface [polypeptide binding]; other site
696747006101	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
696747006102	Chemotaxis phosphatase CheX; Region: CheX; cl15816
696747006103	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747006104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006105	active site
696747006106	phosphorylation site [posttranslational modification]
696747006107	intermolecular recognition site; other site
696747006108	dimerization interface [polypeptide binding]; other site
696747006109	Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862
696747006110	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
696747006111	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696747006112	Predicted dehydrogenase [General function prediction only]; Region: COG0579
696747006113	hydroxyglutarate oxidase; Provisional; Region: PRK11728
696747006114	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
696747006115	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
696747006116	Coenzyme A binding pocket [chemical binding]; other site
696747006117	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
696747006118	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
696747006119	ABC-ATPase subunit  interface; other site
696747006120	dimer interface [polypeptide binding]; other site
696747006121	putative PBP binding regions; other site
696747006122	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
696747006123	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
696747006124	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
696747006125	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
696747006126	metal binding site [ion binding]; metal-binding site
696747006127	Exoribonuclease R [Transcription]; Region: VacB; COG0557
696747006128	RNB domain; Region: RNB; pfam00773
696747006129	ribosomal protein S18; Region: rps18; CHL00077
696747006130	ribosomal protein L33; Region: rpl33; CHL00104
696747006131	RDD family; Region: RDD; pfam06271
696747006132	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
696747006133	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
696747006134	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696747006135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747006136	homodimer interface [polypeptide binding]; other site
696747006137	catalytic residue [active]
696747006138	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
696747006139	catalytic residues [active]
696747006140	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747006141	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
696747006142	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
696747006143	putative active site [active]
696747006144	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
696747006145	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
696747006146	tRNA; other site
696747006147	putative tRNA binding site [nucleotide binding]; other site
696747006148	putative NADP binding site [chemical binding]; other site
696747006149	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
696747006150	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
696747006151	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
696747006152	HIGH motif; other site
696747006153	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
696747006154	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
696747006155	active site
696747006156	KMSKS motif; other site
696747006157	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
696747006158	tRNA binding surface [nucleotide binding]; other site
696747006159	anticodon binding site; other site
696747006160	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
696747006161	AAA domain; Region: AAA_23; pfam13476
696747006162	AAA domain; Region: AAA_21; pfam13304
696747006163	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747006164	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747006165	structural tetrad; other site
696747006166	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747006167	structural tetrad; other site
696747006168	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747006169	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747006170	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747006171	structural tetrad; other site
696747006172	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747006173	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747006174	structural tetrad; other site
696747006175	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
696747006176	hypothetical protein; Provisional; Region: PRK04194
696747006177	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
696747006178	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
696747006179	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
696747006180	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
696747006181	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
696747006182	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332
696747006183	dimer interface [polypeptide binding]; other site
696747006184	catalytic residue [active]
696747006185	metal binding site [ion binding]; metal-binding site
696747006186	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
696747006187	intersubunit interface [polypeptide binding]; other site
696747006188	active site
696747006189	Zn2+ binding site [ion binding]; other site
696747006190	Predicted permease; Region: DUF318; cl17795
696747006191	Predicted permease; Region: DUF318; cl17795
696747006192	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
696747006193	Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043
696747006194	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
696747006195	DNA binding residues [nucleotide binding]
696747006196	dimer interface [polypeptide binding]; other site
696747006197	metal binding site [ion binding]; metal-binding site
696747006198	precorrin-8X methylmutase; Validated; Region: PRK05953
696747006199	Precorrin-8X methylmutase; Region: CbiC; pfam02570
696747006200	dihydrodipicolinate reductase; Provisional; Region: PRK00048
696747006201	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
696747006202	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
696747006203	CHASE2 domain; Region: CHASE2; pfam05226
696747006204	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
696747006205	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747006206	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747006207	metal binding site [ion binding]; metal-binding site
696747006208	active site
696747006209	I-site; other site
696747006210	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747006211	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
696747006212	catalytic triad [active]
696747006213	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
696747006214	Nuclease-related domain; Region: NERD; pfam08378
696747006215	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
696747006216	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
696747006217	Walker A/P-loop; other site
696747006218	ATP binding site [chemical binding]; other site
696747006219	Q-loop/lid; other site
696747006220	ABC transporter signature motif; other site
696747006221	Walker B; other site
696747006222	D-loop; other site
696747006223	H-loop/switch region; other site
696747006224	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
696747006225	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
696747006226	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
696747006227	Walker A/P-loop; other site
696747006228	ATP binding site [chemical binding]; other site
696747006229	Q-loop/lid; other site
696747006230	ABC transporter signature motif; other site
696747006231	Walker B; other site
696747006232	D-loop; other site
696747006233	H-loop/switch region; other site
696747006234	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
696747006235	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
696747006236	metal-binding site [ion binding]
696747006237	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747006238	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747006239	S-adenosylmethionine binding site [chemical binding]; other site
696747006240	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
696747006241	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
696747006242	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
696747006243	Protein of unknown function DUF262; Region: DUF262; pfam03235
696747006244	Uncharacterized conserved protein [Function unknown]; Region: COG1479
696747006245	Protein of unknown function DUF262; Region: DUF262; pfam03235
696747006246	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
696747006247	Phosphotransferase enzyme family; Region: APH; pfam01636
696747006248	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
696747006249	active site
696747006250	ATP binding site [chemical binding]; other site
696747006251	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
696747006252	substrate binding site [chemical binding]; other site
696747006253	Predicted permeases [General function prediction only]; Region: COG0679
696747006254	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
696747006255	putative active site [active]
696747006256	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
696747006257	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
696747006258	dimerization interface [polypeptide binding]; other site
696747006259	active site
696747006260	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747006261	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
696747006262	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
696747006263	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
696747006264	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696747006265	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747006266	active site
696747006267	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
696747006268	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
696747006269	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
696747006270	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
696747006271	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
696747006272	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
696747006273	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
696747006274	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
696747006275	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747006276	Walker A/P-loop; other site
696747006277	ATP binding site [chemical binding]; other site
696747006278	Q-loop/lid; other site
696747006279	ABC transporter signature motif; other site
696747006280	Walker B; other site
696747006281	D-loop; other site
696747006282	H-loop/switch region; other site
696747006283	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747006284	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
696747006285	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747006286	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
696747006287	putative ADP-binding pocket [chemical binding]; other site
696747006288	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747006289	Methyltransferase domain; Region: Methyltransf_11; pfam08241
696747006290	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747006291	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696747006292	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
696747006293	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
696747006294	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
696747006295	Ligand binding site; other site
696747006296	Putative Catalytic site; other site
696747006297	DXD motif; other site
696747006298	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
696747006299	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696747006300	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747006301	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747006302	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696747006303	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
696747006304	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
696747006305	active site
696747006306	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747006307	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
696747006308	putative ADP-binding pocket [chemical binding]; other site
696747006309	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696747006310	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747006311	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
696747006312	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
696747006313	active site
696747006314	catalytic tetrad [active]
696747006315	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
696747006316	tetramer (dimer of dimers) interface [polypeptide binding]; other site
696747006317	active site
696747006318	dimer interface [polypeptide binding]; other site
696747006319	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747006320	binding surface
696747006321	TPR motif; other site
696747006322	TPR repeat; Region: TPR_11; pfam13414
696747006323	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747006324	binding surface
696747006325	TPR motif; other site
696747006326	TPR repeat; Region: TPR_11; pfam13414
696747006327	TPR repeat; Region: TPR_11; pfam13414
696747006328	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747006329	binding surface
696747006330	TPR motif; other site
696747006331	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747006332	TPR repeat; Region: TPR_11; pfam13414
696747006333	TPR repeat; Region: TPR_11; pfam13414
696747006334	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747006335	TPR motif; other site
696747006336	binding surface
696747006337	TPR repeat; Region: TPR_11; pfam13414
696747006338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747006339	binding surface
696747006340	TPR motif; other site
696747006341	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
696747006342	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747006343	binding surface
696747006344	TPR motif; other site
696747006345	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747006346	binding surface
696747006347	TPR motif; other site
696747006348	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696747006349	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747006350	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747006351	active site
696747006352	ATP binding site [chemical binding]; other site
696747006353	substrate binding site [chemical binding]; other site
696747006354	activation loop (A-loop); other site
696747006355	Response regulator receiver domain; Region: Response_reg; pfam00072
696747006356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006357	active site
696747006358	phosphorylation site [posttranslational modification]
696747006359	intermolecular recognition site; other site
696747006360	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747006361	dimerization interface [polypeptide binding]; other site
696747006362	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747006363	dimer interface [polypeptide binding]; other site
696747006364	phosphorylation site [posttranslational modification]
696747006365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747006366	ATP binding site [chemical binding]; other site
696747006367	Mg2+ binding site [ion binding]; other site
696747006368	G-X-G motif; other site
696747006369	Cache domain; Region: Cache_1; pfam02743
696747006370	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747006371	dimerization interface [polypeptide binding]; other site
696747006372	PAS domain S-box; Region: sensory_box; TIGR00229
696747006373	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747006374	putative active site [active]
696747006375	heme pocket [chemical binding]; other site
696747006376	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747006377	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747006378	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747006379	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747006380	dimer interface [polypeptide binding]; other site
696747006381	phosphorylation site [posttranslational modification]
696747006382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747006383	ATP binding site [chemical binding]; other site
696747006384	Mg2+ binding site [ion binding]; other site
696747006385	G-X-G motif; other site
696747006386	Response regulator receiver domain; Region: Response_reg; pfam00072
696747006387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006388	active site
696747006389	phosphorylation site [posttranslational modification]
696747006390	intermolecular recognition site; other site
696747006391	dimerization interface [polypeptide binding]; other site
696747006392	Protein of unknown function (DUF751); Region: DUF751; pfam05421
696747006393	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
696747006394	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747006395	Walker A/P-loop; other site
696747006396	ATP binding site [chemical binding]; other site
696747006397	Q-loop/lid; other site
696747006398	ABC transporter signature motif; other site
696747006399	Walker B; other site
696747006400	D-loop; other site
696747006401	H-loop/switch region; other site
696747006402	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
696747006403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747006404	dimer interface [polypeptide binding]; other site
696747006405	conserved gate region; other site
696747006406	putative PBP binding loops; other site
696747006407	ABC-ATPase subunit interface; other site
696747006408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747006409	dimer interface [polypeptide binding]; other site
696747006410	conserved gate region; other site
696747006411	putative PBP binding loops; other site
696747006412	ABC-ATPase subunit interface; other site
696747006413	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
696747006414	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
696747006415	seryl-tRNA synthetase; Provisional; Region: PRK05431
696747006416	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
696747006417	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
696747006418	dimer interface [polypeptide binding]; other site
696747006419	active site
696747006420	motif 1; other site
696747006421	motif 2; other site
696747006422	motif 3; other site
696747006423	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
696747006424	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747006425	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747006426	active site
696747006427	ATP binding site [chemical binding]; other site
696747006428	substrate binding site [chemical binding]; other site
696747006429	activation loop (A-loop); other site
696747006430	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747006431	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747006432	structural tetrad; other site
696747006433	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747006434	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747006435	active site
696747006436	ATP binding site [chemical binding]; other site
696747006437	substrate binding site [chemical binding]; other site
696747006438	activation loop (A-loop); other site
696747006439	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747006440	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747006441	structural tetrad; other site
696747006442	Cache domain; Region: Cache_1; pfam02743
696747006443	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747006444	dimerization interface [polypeptide binding]; other site
696747006445	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747006446	putative active site [active]
696747006447	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747006448	heme pocket [chemical binding]; other site
696747006449	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747006450	dimer interface [polypeptide binding]; other site
696747006451	phosphorylation site [posttranslational modification]
696747006452	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747006453	ATP binding site [chemical binding]; other site
696747006454	Mg2+ binding site [ion binding]; other site
696747006455	G-X-G motif; other site
696747006456	Response regulator receiver domain; Region: Response_reg; pfam00072
696747006457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006458	active site
696747006459	phosphorylation site [posttranslational modification]
696747006460	intermolecular recognition site; other site
696747006461	dimerization interface [polypeptide binding]; other site
696747006462	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747006463	cyclase homology domain; Region: CHD; cd07302
696747006464	nucleotidyl binding site; other site
696747006465	metal binding site [ion binding]; metal-binding site
696747006466	dimer interface [polypeptide binding]; other site
696747006467	Dam-replacing family; Region: DRP; pfam06044
696747006468	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
696747006469	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696747006470	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
696747006471	Protein of unknown function (DUF1622); Region: DUF1622; cl01991
696747006472	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
696747006473	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
696747006474	Walker A/P-loop; other site
696747006475	ATP binding site [chemical binding]; other site
696747006476	Q-loop/lid; other site
696747006477	ABC transporter signature motif; other site
696747006478	Walker B; other site
696747006479	D-loop; other site
696747006480	H-loop/switch region; other site
696747006481	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
696747006482	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
696747006483	tetramer interface [polypeptide binding]; other site
696747006484	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747006485	catalytic residue [active]
696747006486	Response regulator receiver domain; Region: Response_reg; pfam00072
696747006487	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006488	active site
696747006489	phosphorylation site [posttranslational modification]
696747006490	intermolecular recognition site; other site
696747006491	dimerization interface [polypeptide binding]; other site
696747006492	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747006493	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747006494	metal binding site [ion binding]; metal-binding site
696747006495	active site
696747006496	I-site; other site
696747006497	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747006498	FOG: CBS domain [General function prediction only]; Region: COG0517
696747006499	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747006500	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747006501	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747006502	dimer interface [polypeptide binding]; other site
696747006503	phosphorylation site [posttranslational modification]
696747006504	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747006505	ATP binding site [chemical binding]; other site
696747006506	Mg2+ binding site [ion binding]; other site
696747006507	G-X-G motif; other site
696747006508	NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015
696747006509	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
696747006510	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
696747006511	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
696747006512	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696747006513	NADH dehydrogenase; Region: NADHdh; cl00469
696747006514	citrate synthase; Provisional; Region: PRK14036
696747006515	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112
696747006516	dimer interface [polypeptide binding]; other site
696747006517	active site
696747006518	citrylCoA binding site [chemical binding]; other site
696747006519	oxalacetate/citrate binding site [chemical binding]; other site
696747006520	coenzyme A binding site [chemical binding]; other site
696747006521	catalytic triad [active]
696747006522	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
696747006523	catalytic core [active]
696747006524	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747006525	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747006526	active site
696747006527	alanine racemase; Reviewed; Region: alr; PRK00053
696747006528	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
696747006529	active site
696747006530	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
696747006531	dimer interface [polypeptide binding]; other site
696747006532	substrate binding site [chemical binding]; other site
696747006533	catalytic residues [active]
696747006534	Domain of unknown function (DUF427); Region: DUF427; pfam04248
696747006535	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
696747006536	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
696747006537	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
696747006538	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
696747006539	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
696747006540	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
696747006541	FOG: CBS domain [General function prediction only]; Region: COG0517
696747006542	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747006543	FOG: CBS domain [General function prediction only]; Region: COG0517
696747006544	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
696747006545	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747006546	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747006547	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747006548	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747006549	dimer interface [polypeptide binding]; other site
696747006550	phosphorylation site [posttranslational modification]
696747006551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747006552	ATP binding site [chemical binding]; other site
696747006553	Mg2+ binding site [ion binding]; other site
696747006554	G-X-G motif; other site
696747006555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006556	active site
696747006557	phosphorylation site [posttranslational modification]
696747006558	intermolecular recognition site; other site
696747006559	Response regulator receiver domain; Region: Response_reg; pfam00072
696747006560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006561	active site
696747006562	phosphorylation site [posttranslational modification]
696747006563	intermolecular recognition site; other site
696747006564	dimerization interface [polypeptide binding]; other site
696747006565	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
696747006566	putative binding surface; other site
696747006567	active site
696747006568	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
696747006569	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
696747006570	active site
696747006571	HAS barrel domain; Region: HAS-barrel; pfam09378
696747006572	HerA helicase [Replication, recombination, and repair]; Region: COG0433
696747006573	Domain of unknown function DUF87; Region: DUF87; pfam01935
696747006574	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
696747006575	DNA primase; Validated; Region: dnaG; PRK05667
696747006576	CHC2 zinc finger; Region: zf-CHC2; pfam01807
696747006577	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
696747006578	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
696747006579	active site
696747006580	metal binding site [ion binding]; metal-binding site
696747006581	interdomain interaction site; other site
696747006582	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747006583	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
696747006584	GTP/Mg2+ binding site [chemical binding]; other site
696747006585	G5 box; other site
696747006586	G1 box; other site
696747006587	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747006588	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747006589	structural tetrad; other site
696747006590	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747006591	structural tetrad; other site
696747006592	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747006593	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
696747006594	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
696747006595	GatB domain; Region: GatB_Yqey; smart00845
696747006596	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
696747006597	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747006598	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747006599	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747006600	putative active site [active]
696747006601	putative NTP binding site [chemical binding]; other site
696747006602	putative nucleic acid binding site [nucleotide binding]; other site
696747006603	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747006604	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747006605	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747006606	active site
696747006607	Caspase domain; Region: Peptidase_C14; pfam00656
696747006608	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
696747006609	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747006610	DXD motif; other site
696747006611	Predicted permease [General function prediction only]; Region: COG3329
696747006612	FOG: CBS domain [General function prediction only]; Region: COG0517
696747006613	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
696747006614	CP12 domain; Region: CP12; pfam02672
696747006615	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747006616	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747006617	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747006618	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747006619	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747006620	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747006621	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747006622	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747006623	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747006624	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747006625	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696747006626	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696747006627	MarR family; Region: MarR_2; cl17246
696747006628	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
696747006629	active site
696747006630	catalytic residues [active]
696747006631	DNA binding site [nucleotide binding]
696747006632	Int/Topo IB signature motif; other site
696747006633	Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777
696747006634	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
696747006635	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696747006636	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
696747006637	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
696747006638	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747006639	FeS/SAM binding site; other site
696747006640	HemN C-terminal domain; Region: HemN_C; pfam06969
696747006641	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747006642	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747006643	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747006644	I-site; other site
696747006645	active site
696747006646	metal binding site [ion binding]; metal-binding site
696747006647	Response regulator receiver domain; Region: Response_reg; pfam00072
696747006648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006649	active site
696747006650	phosphorylation site [posttranslational modification]
696747006651	intermolecular recognition site; other site
696747006652	dimerization interface [polypeptide binding]; other site
696747006653	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
696747006654	nucleotidyl binding site; other site
696747006655	metal binding site [ion binding]; metal-binding site
696747006656	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006657	active site
696747006658	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747006659	phosphorylation site [posttranslational modification]
696747006660	intermolecular recognition site; other site
696747006661	dimerization interface [polypeptide binding]; other site
696747006662	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747006663	dimer interface [polypeptide binding]; other site
696747006664	phosphorylation site [posttranslational modification]
696747006665	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747006666	ATP binding site [chemical binding]; other site
696747006667	Mg2+ binding site [ion binding]; other site
696747006668	G-X-G motif; other site
696747006669	RRXRR protein; Region: RRXRR; pfam14239
696747006670	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747006671	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747006672	active site
696747006673	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747006674	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747006675	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747006676	active site
696747006677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006678	active site
696747006679	phosphorylation site [posttranslational modification]
696747006680	intermolecular recognition site; other site
696747006681	dimerization interface [polypeptide binding]; other site
696747006682	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747006683	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747006684	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747006685	dimer interface [polypeptide binding]; other site
696747006686	phosphorylation site [posttranslational modification]
696747006687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747006688	ATP binding site [chemical binding]; other site
696747006689	Mg2+ binding site [ion binding]; other site
696747006690	G-X-G motif; other site
696747006691	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747006692	PAS fold; Region: PAS_3; pfam08447
696747006693	heme pocket [chemical binding]; other site
696747006694	putative active site [active]
696747006695	PAS domain; Region: PAS_9; pfam13426
696747006696	PAS fold; Region: PAS_4; pfam08448
696747006697	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747006698	PAS fold; Region: PAS_3; pfam08447
696747006699	putative active site [active]
696747006700	heme pocket [chemical binding]; other site
696747006701	PAS domain S-box; Region: sensory_box; TIGR00229
696747006702	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747006703	putative active site [active]
696747006704	heme pocket [chemical binding]; other site
696747006705	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747006706	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747006707	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747006708	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696747006709	Ligand Binding Site [chemical binding]; other site
696747006710	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
696747006711	histidinol dehydrogenase; Region: hisD; TIGR00069
696747006712	NAD binding site [chemical binding]; other site
696747006713	dimerization interface [polypeptide binding]; other site
696747006714	product binding site; other site
696747006715	substrate binding site [chemical binding]; other site
696747006716	zinc binding site [ion binding]; other site
696747006717	catalytic residues [active]
696747006718	ribosomal protein S20; Region: rps20; CHL00102
696747006719	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
696747006720	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
696747006721	active site
696747006722	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
696747006723	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
696747006724	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
696747006725	RPB1 interaction site [polypeptide binding]; other site
696747006726	RPB10 interaction site [polypeptide binding]; other site
696747006727	RPB11 interaction site [polypeptide binding]; other site
696747006728	RPB3 interaction site [polypeptide binding]; other site
696747006729	RPB12 interaction site [polypeptide binding]; other site
696747006730	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
696747006731	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
696747006732	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
696747006733	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
696747006734	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
696747006735	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
696747006736	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
696747006737	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
696747006738	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
696747006739	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
696747006740	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
696747006741	DNA binding site [nucleotide binding]
696747006742	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
696747006743	RRXRR protein; Region: RRXRR; pfam14239
696747006744	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747006745	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747006746	active site
696747006747	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696747006748	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696747006749	MarR family; Region: MarR_2; cl17246
696747006750	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
696747006751	active site
696747006752	catalytic residues [active]
696747006753	DNA binding site [nucleotide binding]
696747006754	Int/Topo IB signature motif; other site
696747006755	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
696747006756	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747006757	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747006758	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747006759	PUCC protein; Region: PUCC; pfam03209
696747006760	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696747006761	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
696747006762	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
696747006763	catalytic site [active]
696747006764	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747006765	ligand binding site [chemical binding]; other site
696747006766	flexible hinge region; other site
696747006767	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
696747006768	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
696747006769	MutS domain I; Region: MutS_I; pfam01624
696747006770	MutS domain II; Region: MutS_II; pfam05188
696747006771	MutS domain III; Region: MutS_III; pfam05192
696747006772	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
696747006773	Walker A/P-loop; other site
696747006774	ATP binding site [chemical binding]; other site
696747006775	Q-loop/lid; other site
696747006776	ABC transporter signature motif; other site
696747006777	Walker B; other site
696747006778	D-loop; other site
696747006779	H-loop/switch region; other site
696747006780	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
696747006781	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
696747006782	CHASE2 domain; Region: CHASE2; pfam05226
696747006783	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747006784	cyclase homology domain; Region: CHD; cd07302
696747006785	nucleotidyl binding site; other site
696747006786	metal binding site [ion binding]; metal-binding site
696747006787	dimer interface [polypeptide binding]; other site
696747006788	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
696747006789	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
696747006790	HlyD family secretion protein; Region: HlyD_3; pfam13437
696747006791	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747006792	Homeodomain-like domain; Region: HTH_23; cl17451
696747006793	Winged helix-turn helix; Region: HTH_33; pfam13592
696747006794	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747006795	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
696747006796	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747006797	putative metal binding site; other site
696747006798	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747006799	binding surface
696747006800	TPR motif; other site
696747006801	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747006802	TPR motif; other site
696747006803	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747006804	binding surface
696747006805	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747006806	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747006807	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
696747006808	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
696747006809	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696747006810	Ligand Binding Site [chemical binding]; other site
696747006811	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696747006812	Ligand Binding Site [chemical binding]; other site
696747006813	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
696747006814	active site
696747006815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006816	active site
696747006817	dimerization interface [polypeptide binding]; other site
696747006818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747006819	ATP binding site [chemical binding]; other site
696747006820	Mg2+ binding site [ion binding]; other site
696747006821	G-X-G motif; other site
696747006822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006823	active site
696747006824	phosphorylation site [posttranslational modification]
696747006825	intermolecular recognition site; other site
696747006826	Response regulator receiver domain; Region: Response_reg; pfam00072
696747006827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006828	active site
696747006829	phosphorylation site [posttranslational modification]
696747006830	intermolecular recognition site; other site
696747006831	dimerization interface [polypeptide binding]; other site
696747006832	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747006833	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747006834	metal binding site [ion binding]; metal-binding site
696747006835	active site
696747006836	I-site; other site
696747006837	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747006838	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
696747006839	putative catalytic site [active]
696747006840	putative metal binding site [ion binding]; other site
696747006841	putative phosphate binding site [ion binding]; other site
696747006842	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747006843	PAS domain; Region: PAS_9; pfam13426
696747006844	putative active site [active]
696747006845	heme pocket [chemical binding]; other site
696747006846	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747006847	GAF domain; Region: GAF; pfam01590
696747006848	PAS fold; Region: PAS_4; pfam08448
696747006849	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747006850	putative active site [active]
696747006851	heme pocket [chemical binding]; other site
696747006852	PAS fold; Region: PAS_4; pfam08448
696747006853	GAF domain; Region: GAF; pfam01590
696747006854	GAF domain; Region: GAF_2; pfam13185
696747006855	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747006856	PAS fold; Region: PAS_3; pfam08447
696747006857	putative active site [active]
696747006858	heme pocket [chemical binding]; other site
696747006859	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747006860	PAS domain; Region: PAS_9; pfam13426
696747006861	putative active site [active]
696747006862	heme pocket [chemical binding]; other site
696747006863	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747006864	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747006865	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747006866	dimer interface [polypeptide binding]; other site
696747006867	phosphorylation site [posttranslational modification]
696747006868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747006869	ATP binding site [chemical binding]; other site
696747006870	Mg2+ binding site [ion binding]; other site
696747006871	G-X-G motif; other site
696747006872	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
696747006873	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
696747006874	hypothetical protein; Provisional; Region: PRK02724
696747006875	tellurium resistance terB-like protein; Region: terB_like; cd07177
696747006876	metal binding site [ion binding]; metal-binding site
696747006877	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
696747006878	aminodeoxychorismate synthase; Provisional; Region: PRK07508
696747006879	chorismate binding enzyme; Region: Chorismate_bind; cl10555
696747006880	hypothetical protein; Provisional; Region: PRK07546
696747006881	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
696747006882	substrate-cofactor binding pocket; other site
696747006883	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747006884	catalytic residue [active]
696747006885	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
696747006886	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
696747006887	putative ribose interaction site [chemical binding]; other site
696747006888	putative ADP binding site [chemical binding]; other site
696747006889	Response regulator receiver domain; Region: Response_reg; pfam00072
696747006890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747006891	active site
696747006892	phosphorylation site [posttranslational modification]
696747006893	intermolecular recognition site; other site
696747006894	dimerization interface [polypeptide binding]; other site
696747006895	lipoyl synthase; Provisional; Region: PRK12928
696747006896	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747006897	FeS/SAM binding site; other site
696747006898	YcfA-like protein; Region: YcfA; pfam07927
696747006899	Uncharacterized conserved protein [Function unknown]; Region: COG4279
696747006900	Uncharacterized conserved protein [Function unknown]; Region: COG4279
696747006901	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
696747006902	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
696747006903	NMT1-like family; Region: NMT1_2; pfam13379
696747006904	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
696747006905	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747006906	dimer interface [polypeptide binding]; other site
696747006907	conserved gate region; other site
696747006908	putative PBP binding loops; other site
696747006909	ABC-ATPase subunit interface; other site
696747006910	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
696747006911	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
696747006912	Walker A/P-loop; other site
696747006913	ATP binding site [chemical binding]; other site
696747006914	Q-loop/lid; other site
696747006915	ABC transporter signature motif; other site
696747006916	Walker B; other site
696747006917	D-loop; other site
696747006918	H-loop/switch region; other site
696747006919	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
696747006920	SnoaL-like domain; Region: SnoaL_2; pfam12680
696747006921	cyanate hydratase; Validated; Region: PRK02866
696747006922	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
696747006923	oligomer interface [polypeptide binding]; other site
696747006924	active site
696747006925	L-asparaginase II; Region: Asparaginase_II; cl01842
696747006926	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
696747006927	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
696747006928	putative glycosyl transferase; Provisional; Region: PRK10307
696747006929	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
696747006930	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
696747006931	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
696747006932	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
696747006933	putative NAD(P) binding site [chemical binding]; other site
696747006934	putative active site [active]
696747006935	Dynamin family; Region: Dynamin_N; pfam00350
696747006936	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
696747006937	G1 box; other site
696747006938	GTP/Mg2+ binding site [chemical binding]; other site
696747006939	Switch I region; other site
696747006940	G2 box; other site
696747006941	Switch II region; other site
696747006942	G3 box; other site
696747006943	G4 box; other site
696747006944	Domain of unknown function (DUF697); Region: DUF697; pfam05128
696747006945	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
696747006946	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
696747006947	putative NAD(P) binding site [chemical binding]; other site
696747006948	catalytic Zn binding site [ion binding]; other site
696747006949	structural Zn binding site [ion binding]; other site
696747006950	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747006951	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747006952	dimer interface [polypeptide binding]; other site
696747006953	phosphorylation site [posttranslational modification]
696747006954	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747006955	ATP binding site [chemical binding]; other site
696747006956	Mg2+ binding site [ion binding]; other site
696747006957	G-X-G motif; other site
696747006958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747006959	active site
696747006960	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747006961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747006962	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747006963	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747006964	putative active site [active]
696747006965	putative nucleic acid binding site [nucleotide binding]; other site
696747006966	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747006967	putative NTP binding site [chemical binding]; other site
696747006968	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747006969	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747006970	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747006971	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747006972	putative active site [active]
696747006973	putative nucleic acid binding site [nucleotide binding]; other site
696747006974	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747006975	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747006976	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747006977	active site
696747006978	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747006979	putative NTP binding site [chemical binding]; other site
696747006980	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747006981	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747006982	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747006983	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747006984	putative active site [active]
696747006985	putative nucleic acid binding site [nucleotide binding]; other site
696747006986	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747006987	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747006988	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747006989	active site
696747006990	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747006991	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747006992	putative NTP binding site [chemical binding]; other site
696747006993	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747006994	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
696747006995	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
696747006996	HIGH motif; other site
696747006997	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
696747006998	active site
696747006999	KMSKS motif; other site
696747007000	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
696747007001	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747007002	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747007003	active site
696747007004	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747007005	Winged helix-turn helix; Region: HTH_33; pfam13592
696747007006	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747007007	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747007008	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747007009	Winged helix-turn helix; Region: HTH_33; pfam13592
696747007010	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747007011	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747007012	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747007013	putative NTP binding site [chemical binding]; other site
696747007014	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747007015	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747007016	putative active site [active]
696747007017	putative nucleic acid binding site [nucleotide binding]; other site
696747007018	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747007019	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747007020	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747007021	active site
696747007022	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
696747007023	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
696747007024	DNA binding site [nucleotide binding]
696747007025	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747007026	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747007027	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747007028	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747007029	binding surface
696747007030	TPR motif; other site
696747007031	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747007032	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747007033	putative active site [active]
696747007034	putative NTP binding site [chemical binding]; other site
696747007035	putative nucleic acid binding site [nucleotide binding]; other site
696747007036	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
696747007037	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
696747007038	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
696747007039	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
696747007040	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
696747007041	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
696747007042	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
696747007043	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
696747007044	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
696747007045	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
696747007046	CRISPR-associated protein; Region: DUF3692; pfam12469
696747007047	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
696747007048	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
696747007049	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
696747007050	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747007051	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747007052	NTP binding site [chemical binding]; other site
696747007053	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747007054	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747007055	putative active site [active]
696747007056	putative nucleic acid binding site [nucleotide binding]; other site
696747007057	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747007058	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747007059	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747007060	active site
696747007061	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747007062	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747007063	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
696747007064	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
696747007065	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
696747007066	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
696747007067	substrate binding site [chemical binding]; other site
696747007068	active site
696747007069	catalytic residues [active]
696747007070	heterodimer interface [polypeptide binding]; other site
696747007071	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
696747007072	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
696747007073	active site
696747007074	catalytic tetrad [active]
696747007075	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
696747007076	GIY-YIG motif/motif A; other site
696747007077	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
696747007078	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747007079	G1 box; other site
696747007080	GTP/Mg2+ binding site [chemical binding]; other site
696747007081	G2 box; other site
696747007082	Switch I region; other site
696747007083	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747007084	G3 box; other site
696747007085	Switch II region; other site
696747007086	G4 box; other site
696747007087	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747007088	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747007089	active site
696747007090	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
696747007091	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
696747007092	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
696747007093	dimer interface [polypeptide binding]; other site
696747007094	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747007095	catalytic residue [active]
696747007096	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
696747007097	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
696747007098	dimer interface [polypeptide binding]; other site
696747007099	decamer (pentamer of dimers) interface [polypeptide binding]; other site
696747007100	catalytic triad [active]
696747007101	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
696747007102	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
696747007103	heat shock protein 90; Provisional; Region: PRK05218
696747007104	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747007105	ATP binding site [chemical binding]; other site
696747007106	Mg2+ binding site [ion binding]; other site
696747007107	G-X-G motif; other site
696747007108	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747007109	active site
696747007110	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696747007111	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747007112	active site
696747007113	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747007114	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747007115	active site
696747007116	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
696747007117	Clp amino terminal domain; Region: Clp_N; pfam02861
696747007118	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747007119	Walker A motif; other site
696747007120	ATP binding site [chemical binding]; other site
696747007121	Walker B motif; other site
696747007122	arginine finger; other site
696747007123	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747007124	Walker A motif; other site
696747007125	ATP binding site [chemical binding]; other site
696747007126	Walker B motif; other site
696747007127	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
696747007128	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
696747007129	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
696747007130	dimer interface [polypeptide binding]; other site
696747007131	active site
696747007132	metal binding site [ion binding]; metal-binding site
696747007133	glutathione binding site [chemical binding]; other site
696747007134	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
696747007135	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
696747007136	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747007137	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
696747007138	Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
696747007139	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
696747007140	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
696747007141	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
696747007142	metal binding site [ion binding]; metal-binding site
696747007143	dimer interface [polypeptide binding]; other site
696747007144	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
696747007145	active site
696747007146	catalytic site [active]
696747007147	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747007148	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
696747007149	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
696747007150	Class I aldolases; Region: Aldolase_Class_I; cl17187
696747007151	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747007152	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747007153	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747007154	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747007155	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747007156	Winged helix-turn helix; Region: HTH_29; pfam13551
696747007157	Homeodomain-like domain; Region: HTH_23; cl17451
696747007158	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
696747007159	Dihaem cytochrome c; Region: DHC; pfam09626
696747007160	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
696747007161	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
696747007162	G1 box; other site
696747007163	GTP/Mg2+ binding site [chemical binding]; other site
696747007164	Switch I region; other site
696747007165	G2 box; other site
696747007166	Switch II region; other site
696747007167	G3 box; other site
696747007168	G4 box; other site
696747007169	G5 box; other site
696747007170	Domain of unknown function (DUF697); Region: DUF697; pfam05128
696747007171	aspartate aminotransferase; Provisional; Region: PRK05957
696747007172	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696747007173	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747007174	homodimer interface [polypeptide binding]; other site
696747007175	catalytic residue [active]
696747007176	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
696747007177	dimer interface [polypeptide binding]; other site
696747007178	catalytic triad [active]
696747007179	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
696747007180	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
696747007181	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
696747007182	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
696747007183	PsaD; Region: PsaD; pfam02531
696747007184	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
696747007185	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747007186	Switch II region; other site
696747007187	Uncharacterized conserved protein [Function unknown]; Region: COG1434
696747007188	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
696747007189	putative active site [active]
696747007190	Pex19 protein family; Region: Pex19; pfam04614
696747007191	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747007192	Methyltransferase domain; Region: Methyltransf_12; pfam08242
696747007193	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
696747007194	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
696747007195	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
696747007196	putative active site [active]
696747007197	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
696747007198	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
696747007199	alpha-gamma subunit interface [polypeptide binding]; other site
696747007200	beta-gamma subunit interface [polypeptide binding]; other site
696747007201	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
696747007202	gamma-beta subunit interface [polypeptide binding]; other site
696747007203	alpha-beta subunit interface [polypeptide binding]; other site
696747007204	urease subunit alpha; Reviewed; Region: ureC; PRK13207
696747007205	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
696747007206	subunit interactions [polypeptide binding]; other site
696747007207	active site
696747007208	flap region; other site
696747007209	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747007210	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747007211	metal binding site [ion binding]; metal-binding site
696747007212	active site
696747007213	I-site; other site
696747007214	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747007215	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747007216	putative active site [active]
696747007217	heme pocket [chemical binding]; other site
696747007218	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747007219	putative active site [active]
696747007220	heme pocket [chemical binding]; other site
696747007221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747007222	putative active site [active]
696747007223	heme pocket [chemical binding]; other site
696747007224	GAF domain; Region: GAF; cl17456
696747007225	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
696747007226	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747007227	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
696747007228	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
696747007229	substrate binding pocket [chemical binding]; other site
696747007230	membrane-bound complex binding site; other site
696747007231	hinge residues; other site
696747007232	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
696747007233	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
696747007234	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
696747007235	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747007236	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
696747007237	structural tetrad; other site
696747007238	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
696747007239	Cache domain; Region: Cache_1; pfam02743
696747007240	HAMP domain; Region: HAMP; pfam00672
696747007241	dimerization interface [polypeptide binding]; other site
696747007242	phage tail protein domain; Region: tail_TIGR02242
696747007243	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
696747007244	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
696747007245	Protein of unknown function, DUF399; Region: DUF399; pfam04187
696747007246	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
696747007247	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
696747007248	active site
696747007249	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
696747007250	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
696747007251	catalytic residues [active]
696747007252	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
696747007253	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696747007254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747007255	active site
696747007256	phosphorylation site [posttranslational modification]
696747007257	intermolecular recognition site; other site
696747007258	dimerization interface [polypeptide binding]; other site
696747007259	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747007260	DNA binding site [nucleotide binding]
696747007261	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
696747007262	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
696747007263	Bacterial SH3 domain homologues; Region: SH3b; smart00287
696747007264	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696747007265	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696747007266	active site
696747007267	metal binding site [ion binding]; metal-binding site
696747007268	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
696747007269	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
696747007270	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
696747007271	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
696747007272	active site
696747007273	SAM binding site [chemical binding]; other site
696747007274	homodimer interface [polypeptide binding]; other site
696747007275	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
696747007276	active site
696747007277	SAM binding site [chemical binding]; other site
696747007278	homodimer interface [polypeptide binding]; other site
696747007279	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
696747007280	Precorrin-8X methylmutase; Region: CbiC; pfam02570
696747007281	precorrin-3B synthase; Region: CobG; TIGR02435
696747007282	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
696747007283	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
696747007284	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
696747007285	active site
696747007286	putative homodimer interface [polypeptide binding]; other site
696747007287	SAM binding site [chemical binding]; other site
696747007288	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
696747007289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747007290	S-adenosylmethionine binding site [chemical binding]; other site
696747007291	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
696747007292	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
696747007293	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
696747007294	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
696747007295	inhibitor-cofactor binding pocket; inhibition site
696747007296	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747007297	catalytic residue [active]
696747007298	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
696747007299	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
696747007300	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
696747007301	metal binding site [ion binding]; metal-binding site
696747007302	Response regulator receiver domain; Region: Response_reg; pfam00072
696747007303	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747007304	active site
696747007305	phosphorylation site [posttranslational modification]
696747007306	intermolecular recognition site; other site
696747007307	dimerization interface [polypeptide binding]; other site
696747007308	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
696747007309	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
696747007310	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
696747007311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
696747007312	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
696747007313	Uncharacterized conserved protein [Function unknown]; Region: COG2308
696747007314	Sporulation and spore germination; Region: Germane; cl11253
696747007315	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
696747007316	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
696747007317	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
696747007318	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
696747007319	catalytic triad [active]
696747007320	conserved cis-peptide bond; other site
696747007321	Homeodomain-like domain; Region: HTH_23; pfam13384
696747007322	Winged helix-turn helix; Region: HTH_29; pfam13551
696747007323	Homeodomain-like domain; Region: HTH_32; pfam13565
696747007324	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
696747007325	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696747007326	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
696747007327	Walker A/P-loop; other site
696747007328	ATP binding site [chemical binding]; other site
696747007329	Q-loop/lid; other site
696747007330	ABC transporter signature motif; other site
696747007331	Walker B; other site
696747007332	D-loop; other site
696747007333	H-loop/switch region; other site
696747007334	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
696747007335	oligomer interface [polypeptide binding]; other site
696747007336	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
696747007337	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
696747007338	nucleotide binding site [chemical binding]; other site
696747007339	putative NEF/HSP70 interaction site [polypeptide binding]; other site
696747007340	SBD interface [polypeptide binding]; other site
696747007341	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696747007342	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
696747007343	active site
696747007344	metal binding site [ion binding]; metal-binding site
696747007345	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696747007346	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
696747007347	active site
696747007348	metal binding site [ion binding]; metal-binding site
696747007349	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
696747007350	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
696747007351	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
696747007352	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
696747007353	active site
696747007354	intersubunit interface [polypeptide binding]; other site
696747007355	catalytic residue [active]
696747007356	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
696747007357	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
696747007358	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
696747007359	putative dimer interface [polypeptide binding]; other site
696747007360	N-terminal domain interface [polypeptide binding]; other site
696747007361	putative substrate binding pocket (H-site) [chemical binding]; other site
696747007362	DNA methylase; Region: N6_N4_Mtase; pfam01555
696747007363	putative high light inducible protein; Region: PHA02337
696747007364	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
696747007365	homotrimer interaction site [polypeptide binding]; other site
696747007366	zinc binding site [ion binding]; other site
696747007367	CDP-binding sites; other site
696747007368	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
696747007369	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
696747007370	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
696747007371	AIR carboxylase; Region: AIRC; smart01001
696747007372	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696747007373	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
696747007374	Coenzyme A binding pocket [chemical binding]; other site
696747007375	Response regulator receiver domain; Region: Response_reg; pfam00072
696747007376	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747007377	active site
696747007378	phosphorylation site [posttranslational modification]
696747007379	intermolecular recognition site; other site
696747007380	dimerization interface [polypeptide binding]; other site
696747007381	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747007382	GAF domain; Region: GAF; pfam01590
696747007383	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747007384	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747007385	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747007386	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747007387	dimer interface [polypeptide binding]; other site
696747007388	phosphorylation site [posttranslational modification]
696747007389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747007390	ATP binding site [chemical binding]; other site
696747007391	Mg2+ binding site [ion binding]; other site
696747007392	G-X-G motif; other site
696747007393	Response regulator receiver domain; Region: Response_reg; pfam00072
696747007394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747007395	active site
696747007396	phosphorylation site [posttranslational modification]
696747007397	intermolecular recognition site; other site
696747007398	dimerization interface [polypeptide binding]; other site
696747007399	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747007400	cyclase homology domain; Region: CHD; cd07302
696747007401	nucleotidyl binding site; other site
696747007402	metal binding site [ion binding]; metal-binding site
696747007403	dimer interface [polypeptide binding]; other site
696747007404	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747007405	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747007406	putative active site [active]
696747007407	putative NTP binding site [chemical binding]; other site
696747007408	putative nucleic acid binding site [nucleotide binding]; other site
696747007409	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747007410	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747007411	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747007412	active site
696747007413	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747007414	Protein of unknown function (DUF1347); Region: DUF1347; pfam07079
696747007415	Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
696747007416	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
696747007417	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747007418	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747007419	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747007420	putative NTP binding site [chemical binding]; other site
696747007421	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747007422	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747007423	putative active site [active]
696747007424	putative nucleic acid binding site [nucleotide binding]; other site
696747007425	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747007426	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747007427	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747007428	active site
696747007429	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747007430	Helix-turn-helix domain; Region: HTH_28; pfam13518
696747007431	Winged helix-turn helix; Region: HTH_33; pfam13592
696747007432	aspartate kinase; Provisional; Region: PRK07431
696747007433	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
696747007434	putative nucleotide binding site [chemical binding]; other site
696747007435	putative catalytic residues [active]
696747007436	putative Mg ion binding site [ion binding]; other site
696747007437	putative aspartate binding site [chemical binding]; other site
696747007438	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
696747007439	putative allosteric regulatory site; other site
696747007440	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
696747007441	putative allosteric regulatory residue; other site
696747007442	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
696747007443	putative allosteric regulatory site; other site
696747007444	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
696747007445	putative allosteric regulatory residue; other site
696747007446	Predicted permease; Region: DUF318; pfam03773
696747007447	TIGR03943 family protein; Region: TIGR03943
696747007448	HEAT repeats; Region: HEAT_2; pfam13646
696747007449	HEAT repeats; Region: HEAT_2; pfam13646
696747007450	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
696747007451	HEAT repeats; Region: HEAT_2; pfam13646
696747007452	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
696747007453	active site
696747007454	SAM binding site [chemical binding]; other site
696747007455	homodimer interface [polypeptide binding]; other site
696747007456	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
696747007457	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
696747007458	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
696747007459	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747007460	putative active site [active]
696747007461	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
696747007462	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
696747007463	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696747007464	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696747007465	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
696747007466	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
696747007467	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696747007468	motif II; other site
696747007469	Response regulator receiver domain; Region: Response_reg; pfam00072
696747007470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747007471	active site
696747007472	phosphorylation site [posttranslational modification]
696747007473	intermolecular recognition site; other site
696747007474	dimerization interface [polypeptide binding]; other site
696747007475	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
696747007476	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747007477	active site
696747007478	phosphorylation site [posttranslational modification]
696747007479	intermolecular recognition site; other site
696747007480	dimerization interface [polypeptide binding]; other site
696747007481	CheB methylesterase; Region: CheB_methylest; pfam01339
696747007482	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
696747007483	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
696747007484	putative binding surface; other site
696747007485	active site
696747007486	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
696747007487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747007488	ATP binding site [chemical binding]; other site
696747007489	Mg2+ binding site [ion binding]; other site
696747007490	G-X-G motif; other site
696747007491	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
696747007492	Response regulator receiver domain; Region: Response_reg; pfam00072
696747007493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747007494	active site
696747007495	phosphorylation site [posttranslational modification]
696747007496	intermolecular recognition site; other site
696747007497	dimerization interface [polypeptide binding]; other site
696747007498	CHASE3 domain; Region: CHASE3; cl05000
696747007499	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696747007500	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696747007501	dimer interface [polypeptide binding]; other site
696747007502	putative CheW interface [polypeptide binding]; other site
696747007503	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
696747007504	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696747007505	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696747007506	dimer interface [polypeptide binding]; other site
696747007507	putative CheW interface [polypeptide binding]; other site
696747007508	CheW-like domain; Region: CheW; pfam01584
696747007509	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
696747007510	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
696747007511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747007512	S-adenosylmethionine binding site [chemical binding]; other site
696747007513	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747007514	binding surface
696747007515	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747007516	TPR motif; other site
696747007517	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
696747007518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747007519	Walker A motif; other site
696747007520	ATP binding site [chemical binding]; other site
696747007521	Walker B motif; other site
696747007522	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
696747007523	RxxxH motif; other site
696747007524	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
696747007525	4Fe-4S binding domain; Region: Fer4; pfam00037
696747007526	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
696747007527	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
696747007528	hypothetical protein; Provisional; Region: PRK02509
696747007529	Uncharacterized conserved protein [Function unknown]; Region: COG1615
696747007530	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
696747007531	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
696747007532	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
696747007533	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
696747007534	Walker A/P-loop; other site
696747007535	ATP binding site [chemical binding]; other site
696747007536	Q-loop/lid; other site
696747007537	ABC transporter signature motif; other site
696747007538	Walker B; other site
696747007539	D-loop; other site
696747007540	H-loop/switch region; other site
696747007541	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
696747007542	putative carbohydrate binding site [chemical binding]; other site
696747007543	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747007544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747007545	S-adenosylmethionine binding site [chemical binding]; other site
696747007546	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
696747007547	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747007548	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
696747007549	Probable Catalytic site; other site
696747007550	metal-binding site
696747007551	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
696747007552	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
696747007553	Probable Catalytic site; other site
696747007554	metal-binding site
696747007555	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747007556	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696747007557	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696747007558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747007559	S-adenosylmethionine binding site [chemical binding]; other site
696747007560	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
696747007561	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
696747007562	macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450
696747007563	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747007564	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747007565	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747007566	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747007567	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747007568	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747007569	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
696747007570	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722
696747007571	phosphate binding site [ion binding]; other site
696747007572	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
696747007573	putative active site [active]
696747007574	substrate binding site [chemical binding]; other site
696747007575	redox center [active]
696747007576	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
696747007577	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
696747007578	CHASE2 domain; Region: CHASE2; pfam05226
696747007579	PAS fold; Region: PAS_4; pfam08448
696747007580	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747007581	putative active site [active]
696747007582	heme pocket [chemical binding]; other site
696747007583	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747007584	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747007585	metal binding site [ion binding]; metal-binding site
696747007586	active site
696747007587	I-site; other site
696747007588	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
696747007589	ribosomal protein S14; Region: rps14; CHL00074
696747007590	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
696747007591	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
696747007592	minor groove reading motif; other site
696747007593	helix-hairpin-helix signature motif; other site
696747007594	substrate binding pocket [chemical binding]; other site
696747007595	active site
696747007596	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
696747007597	RIP metalloprotease RseP; Region: TIGR00054
696747007598	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
696747007599	active site
696747007600	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
696747007601	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
696747007602	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
696747007603	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696747007604	active site
696747007605	motif I; other site
696747007606	motif II; other site
696747007607	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
696747007608	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747007609	cofactor binding site; other site
696747007610	DNA binding site [nucleotide binding]
696747007611	substrate interaction site [chemical binding]; other site
696747007612	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
696747007613	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
696747007614	dimer interface [polypeptide binding]; other site
696747007615	active site
696747007616	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
696747007617	active site
696747007618	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
696747007619	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
696747007620	D1 interface; other site
696747007621	chlorophyll binding site; other site
696747007622	pheophytin binding site; other site
696747007623	beta carotene binding site; other site
696747007624	cytochrome b559 beta interface; other site
696747007625	quinone binding site; other site
696747007626	cytochrome b559 alpha interface; other site
696747007627	protein J interface; other site
696747007628	protein H interface; other site
696747007629	protein X interface; other site
696747007630	core light harvesting protein interface; other site
696747007631	protein L interface; other site
696747007632	CP43 interface; other site
696747007633	protein T interface; other site
696747007634	Fe binding site [ion binding]; other site
696747007635	protein M interface; other site
696747007636	Mn-stabilizing polypeptide interface; other site
696747007637	bromide binding site; other site
696747007638	cytochrome c-550 interface; other site
696747007639	photosystem II 44 kDa protein; Region: psbC; CHL00035
696747007640	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
696747007641	polyphosphate kinase; Provisional; Region: PRK05443
696747007642	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
696747007643	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
696747007644	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
696747007645	putative domain interface [polypeptide binding]; other site
696747007646	putative active site [active]
696747007647	catalytic site [active]
696747007648	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
696747007649	putative domain interface [polypeptide binding]; other site
696747007650	putative active site [active]
696747007651	catalytic site [active]
696747007652	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
696747007653	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
696747007654	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
696747007655	nucleotide binding site [chemical binding]; other site
696747007656	NEF interaction site [polypeptide binding]; other site
696747007657	SBD interface [polypeptide binding]; other site
696747007658	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
696747007659	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
696747007660	gamma subunit interface [polypeptide binding]; other site
696747007661	epsilon subunit interface [polypeptide binding]; other site
696747007662	LBP interface [polypeptide binding]; other site
696747007663	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
696747007664	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
696747007665	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
696747007666	alpha subunit interaction interface [polypeptide binding]; other site
696747007667	Walker A motif; other site
696747007668	ATP binding site [chemical binding]; other site
696747007669	Walker B motif; other site
696747007670	inhibitor binding site; inhibition site
696747007671	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
696747007672	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
696747007673	PLD-like domain; Region: PLDc_2; pfam13091
696747007674	putative active site [active]
696747007675	catalytic site [active]
696747007676	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747007677	ATP binding site [chemical binding]; other site
696747007678	putative Mg++ binding site [ion binding]; other site
696747007679	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747007680	nucleotide binding region [chemical binding]; other site
696747007681	ATP-binding site [chemical binding]; other site
696747007682	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
696747007683	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
696747007684	putative active site [active]
696747007685	PemK-like protein; Region: PemK; pfam02452
696747007686	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
696747007687	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
696747007688	TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271
696747007689	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
696747007690	Protein of unknown function (DUF499); Region: DUF499; pfam04465
696747007691	cell division topological specificity factor MinE; Provisional; Region: PRK13988
696747007692	septum site-determining protein MinD; Region: minD_bact; TIGR01968
696747007693	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
696747007694	Switch I; other site
696747007695	Switch II; other site
696747007696	septum formation inhibitor; Reviewed; Region: minC; PRK00513
696747007697	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
696747007698	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
696747007699	L-aspartate oxidase; Provisional; Region: PRK06175
696747007700	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
696747007701	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
696747007702	Transglycosylase; Region: Transgly; pfam00912
696747007703	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
696747007704	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
696747007705	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
696747007706	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
696747007707	active site
696747007708	purine riboside binding site [chemical binding]; other site
696747007709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
696747007710	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696747007711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747007712	active site
696747007713	phosphorylation site [posttranslational modification]
696747007714	intermolecular recognition site; other site
696747007715	dimerization interface [polypeptide binding]; other site
696747007716	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747007717	DNA binding site [nucleotide binding]
696747007718	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747007719	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747007720	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747007721	putative active site [active]
696747007722	putative NTP binding site [chemical binding]; other site
696747007723	putative nucleic acid binding site [nucleotide binding]; other site
696747007724	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747007725	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747007726	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747007727	active site
696747007728	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747007729	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747007730	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747007731	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747007732	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
696747007733	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747007734	Winged helix-turn helix; Region: HTH_33; pfam13592
696747007735	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747007736	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747007737	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747007738	Homeodomain-like domain; Region: HTH_23; pfam13384
696747007739	Winged helix-turn helix; Region: HTH_33; pfam13592
696747007740	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747007741	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
696747007742	DNA topoisomerase 2-like protein; Provisional; Region: PTZ00108
696747007743	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
696747007744	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747007745	Walker A motif; other site
696747007746	ATP binding site [chemical binding]; other site
696747007747	Walker B motif; other site
696747007748	arginine finger; other site
696747007749	Gas vesicle protein; Region: Gas_vesicle; pfam00741
696747007750	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696747007751	dimerization interface [polypeptide binding]; other site
696747007752	putative DNA binding site [nucleotide binding]; other site
696747007753	putative Zn2+ binding site [ion binding]; other site
696747007754	hydrolase, alpha/beta fold family protein; Region: PLN02824
696747007755	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747007756	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
696747007757	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747007758	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747007759	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696747007760	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696747007761	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747007762	active site
696747007763	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
696747007764	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
696747007765	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696747007766	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747007767	ligand binding site [chemical binding]; other site
696747007768	flexible hinge region; other site
696747007769	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
696747007770	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
696747007771	putative active site [active]
696747007772	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696747007773	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747007774	Walker A/P-loop; other site
696747007775	ATP binding site [chemical binding]; other site
696747007776	Q-loop/lid; other site
696747007777	ABC transporter signature motif; other site
696747007778	Walker B; other site
696747007779	D-loop; other site
696747007780	H-loop/switch region; other site
696747007781	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
696747007782	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
696747007783	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
696747007784	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
696747007785	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
696747007786	NADP binding site [chemical binding]; other site
696747007787	active site
696747007788	putative substrate binding site [chemical binding]; other site
696747007789	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
696747007790	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
696747007791	substrate binding site; other site
696747007792	metal-binding site
696747007793	Oligomer interface; other site
696747007794	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
696747007795	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
696747007796	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696747007797	active site
696747007798	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
696747007799	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
696747007800	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747007801	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
696747007802	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
696747007803	putative active site [active]
696747007804	metal binding site [ion binding]; metal-binding site
696747007805	aspartate aminotransferase; Provisional; Region: PRK05942
696747007806	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696747007807	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747007808	homodimer interface [polypeptide binding]; other site
696747007809	catalytic residue [active]
696747007810	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
696747007811	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
696747007812	RimK-like ATP-grasp domain; Region: RimK; pfam08443
696747007813	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696747007814	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747007815	S-adenosylmethionine binding site [chemical binding]; other site
696747007816	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
696747007817	Mechanosensitive ion channel; Region: MS_channel; pfam00924
696747007818	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
696747007819	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
696747007820	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747007821	dimer interface [polypeptide binding]; other site
696747007822	phosphorylation site [posttranslational modification]
696747007823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747007824	ATP binding site [chemical binding]; other site
696747007825	Mg2+ binding site [ion binding]; other site
696747007826	G-X-G motif; other site
696747007827	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696747007828	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696747007829	Peptidase family M23; Region: Peptidase_M23; pfam01551
696747007830	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
696747007831	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747007832	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
696747007833	protein binding site [polypeptide binding]; other site
696747007834	Protein of unknown function (DUF760); Region: DUF760; pfam05542
696747007835	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
696747007836	SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049
696747007837	reactive center loop; other site
696747007838	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
696747007839	substrate binding site [chemical binding]; other site
696747007840	putative active site [active]
696747007841	redox center [active]
696747007842	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
696747007843	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
696747007844	FMN binding site [chemical binding]; other site
696747007845	active site
696747007846	catalytic residues [active]
696747007847	substrate binding site [chemical binding]; other site
696747007848	ornithine carbamoyltransferase; Provisional; Region: PRK00779
696747007849	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
696747007850	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
696747007851	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747007852	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747007853	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747007854	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747007855	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747007856	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747007857	cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153
696747007858	cyanoexosortase A; Region: cyanoexo_CrtA; TIGR03763
696747007859	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
696747007860	Winged helix-turn helix; Region: HTH_33; pfam13592
696747007861	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747007862	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747007863	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
696747007864	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
696747007865	Protein of unknown function, DUF608; Region: DUF608; pfam04685
696747007866	Phenylalanine zipper; Region: Phe_ZIP; pfam08916
696747007867	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
696747007868	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696747007869	Coenzyme A binding pocket [chemical binding]; other site
696747007870	Predicted permeases [General function prediction only]; Region: COG0795
696747007871	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
696747007872	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
696747007873	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
696747007874	Walker A/P-loop; other site
696747007875	ATP binding site [chemical binding]; other site
696747007876	Q-loop/lid; other site
696747007877	ABC transporter signature motif; other site
696747007878	Walker B; other site
696747007879	D-loop; other site
696747007880	H-loop/switch region; other site
696747007881	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
696747007882	OstA-like protein; Region: OstA; pfam03968
696747007883	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
696747007884	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
696747007885	N- and C-terminal domain interface [polypeptide binding]; other site
696747007886	active site
696747007887	MgATP binding site [chemical binding]; other site
696747007888	catalytic site [active]
696747007889	metal binding site [ion binding]; metal-binding site
696747007890	glycerol binding site [chemical binding]; other site
696747007891	homotetramer interface [polypeptide binding]; other site
696747007892	homodimer interface [polypeptide binding]; other site
696747007893	FBP binding site [chemical binding]; other site
696747007894	protein IIAGlc interface [polypeptide binding]; other site
696747007895	LemA family; Region: LemA; cl00742
696747007896	Repair protein; Region: Repair_PSII; pfam04536
696747007897	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
696747007898	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
696747007899	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747007900	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
696747007901	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747007902	Uncharacterized conserved protein [Function unknown]; Region: COG5464
696747007903	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
696747007904	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747007905	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
696747007906	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
696747007907	ligand binding site [chemical binding]; other site
696747007908	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
696747007909	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696747007910	RNA binding surface [nucleotide binding]; other site
696747007911	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
696747007912	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
696747007913	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747007914	cofactor binding site; other site
696747007915	DNA binding site [nucleotide binding]
696747007916	substrate interaction site [chemical binding]; other site
696747007917	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747007918	Phycobilisome protein; Region: Phycobilisome; cl08227
696747007919	glutamine synthetase, type I; Region: GlnA; TIGR00653
696747007920	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
696747007921	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
696747007922	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747007923	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747007924	S-adenosylmethionine binding site [chemical binding]; other site
696747007925	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
696747007926	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
696747007927	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
696747007928	Peptidase family M50; Region: Peptidase_M50; pfam02163
696747007929	active site
696747007930	putative substrate binding region [chemical binding]; other site
696747007931	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
696747007932	photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049
696747007933	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
696747007934	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
696747007935	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
696747007936	dimerization interface [polypeptide binding]; other site
696747007937	active site
696747007938	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
696747007939	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747007940	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747007941	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747007942	Uncharacterized conserved protein [Function unknown]; Region: COG1434
696747007943	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
696747007944	putative active site [active]
696747007945	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
696747007946	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
696747007947	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
696747007948	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
696747007949	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
696747007950	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
696747007951	Walker A/P-loop; other site
696747007952	ATP binding site [chemical binding]; other site
696747007953	Q-loop/lid; other site
696747007954	ABC transporter signature motif; other site
696747007955	Walker B; other site
696747007956	D-loop; other site
696747007957	H-loop/switch region; other site
696747007958	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
696747007959	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
696747007960	Walker A/P-loop; other site
696747007961	ATP binding site [chemical binding]; other site
696747007962	Q-loop/lid; other site
696747007963	ABC transporter signature motif; other site
696747007964	Walker B; other site
696747007965	D-loop; other site
696747007966	H-loop/switch region; other site
696747007967	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
696747007968	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
696747007969	active site
696747007970	dimer interface [polypeptide binding]; other site
696747007971	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
696747007972	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
696747007973	active site
696747007974	HIGH motif; other site
696747007975	dimer interface [polypeptide binding]; other site
696747007976	KMSKS motif; other site
696747007977	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696747007978	RNA binding surface [nucleotide binding]; other site
696747007979	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
696747007980	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696747007981	Walker A motif; other site
696747007982	ATP binding site [chemical binding]; other site
696747007983	Walker B motif; other site
696747007984	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
696747007985	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
696747007986	active site
696747007987	(T/H)XGH motif; other site
696747007988	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
696747007989	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
696747007990	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
696747007991	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
696747007992	HSP70 interaction site [polypeptide binding]; other site
696747007993	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747007994	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747007995	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747007996	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
696747007997	active site
696747007998	hydrophilic channel; other site
696747007999	dimerization interface [polypeptide binding]; other site
696747008000	catalytic residues [active]
696747008001	active site lid [active]
696747008002	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
696747008003	Divergent PAP2 family; Region: DUF212; pfam02681
696747008004	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
696747008005	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
696747008006	substrate binding pocket [chemical binding]; other site
696747008007	chain length determination region; other site
696747008008	substrate-Mg2+ binding site; other site
696747008009	catalytic residues [active]
696747008010	aspartate-rich region 1; other site
696747008011	active site lid residues [active]
696747008012	aspartate-rich region 2; other site
696747008013	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
696747008014	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
696747008015	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
696747008016	homodimer interface [polypeptide binding]; other site
696747008017	NADP binding site [chemical binding]; other site
696747008018	substrate binding site [chemical binding]; other site
696747008019	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
696747008020	Ligand Binding Site [chemical binding]; other site
696747008021	Phosphoglycerate kinase; Region: PGK; pfam00162
696747008022	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
696747008023	substrate binding site [chemical binding]; other site
696747008024	hinge regions; other site
696747008025	ADP binding site [chemical binding]; other site
696747008026	catalytic site [active]
696747008027	MASE1; Region: MASE1; pfam05231
696747008028	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747008029	putative active site [active]
696747008030	heme pocket [chemical binding]; other site
696747008031	PAS domain S-box; Region: sensory_box; TIGR00229
696747008032	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747008033	putative active site [active]
696747008034	heme pocket [chemical binding]; other site
696747008035	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747008036	dimer interface [polypeptide binding]; other site
696747008037	phosphorylation site [posttranslational modification]
696747008038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747008039	ATP binding site [chemical binding]; other site
696747008040	Mg2+ binding site [ion binding]; other site
696747008041	G-X-G motif; other site
696747008042	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
696747008043	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
696747008044	GTP/Mg2+ binding site [chemical binding]; other site
696747008045	G4 box; other site
696747008046	G5 box; other site
696747008047	G1 box; other site
696747008048	Switch I region; other site
696747008049	G2 box; other site
696747008050	G3 box; other site
696747008051	Switch II region; other site
696747008052	hypothetical protein; Provisional; Region: PRK07208
696747008053	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696747008054	Predicted membrane protein [Function unknown]; Region: COG2246
696747008055	GtrA-like protein; Region: GtrA; pfam04138
696747008056	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
696747008057	Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399
696747008058	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
696747008059	Peptidase family M50; Region: Peptidase_M50; pfam02163
696747008060	active site
696747008061	putative substrate binding region [chemical binding]; other site
696747008062	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
696747008063	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747008064	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747008065	active site
696747008066	phosphorylation site [posttranslational modification]
696747008067	intermolecular recognition site; other site
696747008068	dimerization interface [polypeptide binding]; other site
696747008069	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
696747008070	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
696747008071	active site
696747008072	ATP binding site [chemical binding]; other site
696747008073	substrate binding site [chemical binding]; other site
696747008074	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
696747008075	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
696747008076	putative catalytic residues [active]
696747008077	MoxR-like ATPases [General function prediction only]; Region: COG0714
696747008078	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747008079	Walker A motif; other site
696747008080	ATP binding site [chemical binding]; other site
696747008081	Walker B motif; other site
696747008082	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747008083	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008084	binding surface
696747008085	TPR motif; other site
696747008086	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747008087	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747008088	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008089	binding surface
696747008090	TPR motif; other site
696747008091	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747008092	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747008093	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008094	binding surface
696747008095	TPR motif; other site
696747008096	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747008097	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747008098	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008099	binding surface
696747008100	TPR motif; other site
696747008101	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747008102	CHAT domain; Region: CHAT; pfam12770
696747008103	Protein of unknown function, DUF488; Region: DUF488; pfam04343
696747008104	Protein of unknown function, DUF488; Region: DUF488; pfam04343
696747008105	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747008106	Probable transposase; Region: OrfB_IS605; pfam01385
696747008107	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747008108	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747008109	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
696747008110	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
696747008111	Active Sites [active]
696747008112	SOUL heme-binding protein; Region: SOUL; pfam04832
696747008113	Staphylococcal nuclease homologues; Region: SNc; smart00318
696747008114	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
696747008115	Catalytic site; other site
696747008116	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
696747008117	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
696747008118	ATP adenylyltransferase; Region: ATP_transf; pfam09830
696747008119	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
696747008120	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
696747008121	FMN binding site [chemical binding]; other site
696747008122	active site
696747008123	catalytic residues [active]
696747008124	substrate binding site [chemical binding]; other site
696747008125	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747008126	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747008127	GAF domain; Region: GAF; pfam01590
696747008128	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747008129	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747008130	PAS fold; Region: PAS_4; pfam08448
696747008131	putative active site [active]
696747008132	heme pocket [chemical binding]; other site
696747008133	PAS fold; Region: PAS_4; pfam08448
696747008134	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747008135	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747008136	dimer interface [polypeptide binding]; other site
696747008137	phosphorylation site [posttranslational modification]
696747008138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747008139	ATP binding site [chemical binding]; other site
696747008140	Mg2+ binding site [ion binding]; other site
696747008141	G-X-G motif; other site
696747008142	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747008143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747008144	active site
696747008145	phosphorylation site [posttranslational modification]
696747008146	intermolecular recognition site; other site
696747008147	dimerization interface [polypeptide binding]; other site
696747008148	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
696747008149	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747008150	Walker A/P-loop; other site
696747008151	ATP binding site [chemical binding]; other site
696747008152	Q-loop/lid; other site
696747008153	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696747008154	ABC transporter signature motif; other site
696747008155	Walker B; other site
696747008156	D-loop; other site
696747008157	ABC transporter; Region: ABC_tran_2; pfam12848
696747008158	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
696747008159	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
696747008160	HflK protein; Region: hflK; TIGR01933
696747008161	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
696747008162	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
696747008163	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747008164	FOG: CBS domain [General function prediction only]; Region: COG0517
696747008165	FOG: CBS domain [General function prediction only]; Region: COG0517
696747008166	FOG: CBS domain [General function prediction only]; Region: COG0517
696747008167	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
696747008168	PAS domain S-box; Region: sensory_box; TIGR00229
696747008169	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747008170	putative active site [active]
696747008171	heme pocket [chemical binding]; other site
696747008172	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747008173	PAS fold; Region: PAS_3; pfam08447
696747008174	putative active site [active]
696747008175	heme pocket [chemical binding]; other site
696747008176	PAS fold; Region: PAS_4; pfam08448
696747008177	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747008178	PAS fold; Region: PAS_3; pfam08447
696747008179	putative active site [active]
696747008180	heme pocket [chemical binding]; other site
696747008181	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747008182	PAS fold; Region: PAS_3; pfam08447
696747008183	putative active site [active]
696747008184	heme pocket [chemical binding]; other site
696747008185	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747008186	PAS fold; Region: PAS_3; pfam08447
696747008187	putative active site [active]
696747008188	heme pocket [chemical binding]; other site
696747008189	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747008190	PAS fold; Region: PAS_3; pfam08447
696747008191	putative active site [active]
696747008192	heme pocket [chemical binding]; other site
696747008193	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747008194	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747008195	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747008196	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747008197	metal binding site [ion binding]; metal-binding site
696747008198	active site
696747008199	I-site; other site
696747008200	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696747008201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747008202	S-adenosylmethionine binding site [chemical binding]; other site
696747008203	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
696747008204	active site
696747008205	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
696747008206	substrate binding site [chemical binding]; other site
696747008207	metal binding site [ion binding]; metal-binding site
696747008208	Response regulator receiver domain; Region: Response_reg; pfam00072
696747008209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747008210	active site
696747008211	phosphorylation site [posttranslational modification]
696747008212	intermolecular recognition site; other site
696747008213	dimerization interface [polypeptide binding]; other site
696747008214	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747008215	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747008216	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747008217	metal binding site [ion binding]; metal-binding site
696747008218	active site
696747008219	I-site; other site
696747008220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747008221	Response regulator receiver domain; Region: Response_reg; pfam00072
696747008222	active site
696747008223	phosphorylation site [posttranslational modification]
696747008224	intermolecular recognition site; other site
696747008225	dimerization interface [polypeptide binding]; other site
696747008226	PAS domain S-box; Region: sensory_box; TIGR00229
696747008227	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747008228	putative active site [active]
696747008229	heme pocket [chemical binding]; other site
696747008230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747008231	PAS fold; Region: PAS_3; pfam08447
696747008232	putative active site [active]
696747008233	heme pocket [chemical binding]; other site
696747008234	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747008235	dimer interface [polypeptide binding]; other site
696747008236	phosphorylation site [posttranslational modification]
696747008237	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747008238	ATP binding site [chemical binding]; other site
696747008239	Mg2+ binding site [ion binding]; other site
696747008240	G-X-G motif; other site
696747008241	Response regulator receiver domain; Region: Response_reg; pfam00072
696747008242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747008243	active site
696747008244	phosphorylation site [posttranslational modification]
696747008245	intermolecular recognition site; other site
696747008246	dimerization interface [polypeptide binding]; other site
696747008247	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747008248	S-adenosylmethionine binding site [chemical binding]; other site
696747008249	Uncharacterized conserved protein [Function unknown]; Region: COG1565
696747008250	This domain is found in peptide chain release factors; Region: PCRF; smart00937
696747008251	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
696747008252	RF-1 domain; Region: RF-1; pfam00472
696747008253	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747008254	putative active site [active]
696747008255	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747008256	putative active site [active]
696747008257	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
696747008258	DHH family; Region: DHH; pfam01368
696747008259	DHHA1 domain; Region: DHHA1; pfam02272
696747008260	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
696747008261	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696747008262	RNA binding surface [nucleotide binding]; other site
696747008263	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747008264	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008265	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008266	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008267	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
696747008268	homotrimer interaction site [polypeptide binding]; other site
696747008269	putative active site [active]
696747008270	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747008271	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008272	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008273	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008274	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
696747008275	homotrimer interaction site [polypeptide binding]; other site
696747008276	putative active site [active]
696747008277	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
696747008278	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
696747008279	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
696747008280	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
696747008281	homodimer interface [polypeptide binding]; other site
696747008282	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
696747008283	active site pocket [active]
696747008284	Predicted ATPase [General function prediction only]; Region: COG4637
696747008285	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747008286	Walker A/P-loop; other site
696747008287	ATP binding site [chemical binding]; other site
696747008288	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
696747008289	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
696747008290	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
696747008291	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
696747008292	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
696747008293	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
696747008294	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747008295	Walker A motif; other site
696747008296	ATP binding site [chemical binding]; other site
696747008297	Walker B motif; other site
696747008298	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
696747008299	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
696747008300	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696747008301	RNA binding surface [nucleotide binding]; other site
696747008302	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
696747008303	active site
696747008304	Outer membrane efflux protein; Region: OEP; pfam02321
696747008305	Outer membrane efflux protein; Region: OEP; pfam02321
696747008306	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
696747008307	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
696747008308	FtsX-like permease family; Region: FtsX; pfam02687
696747008309	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
696747008310	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
696747008311	lipoyl-biotinyl attachment site [posttranslational modification]; other site
696747008312	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
696747008313	HlyD family secretion protein; Region: HlyD_3; pfam13437
696747008314	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
696747008315	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
696747008316	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
696747008317	active site
696747008318	Predicted transcriptional regulators [Transcription]; Region: COG1695
696747008319	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
696747008320	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
696747008321	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
696747008322	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747008323	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747008324	phosphorylation site [posttranslational modification]
696747008325	dimer interface [polypeptide binding]; other site
696747008326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747008327	ATP binding site [chemical binding]; other site
696747008328	Mg2+ binding site [ion binding]; other site
696747008329	G-X-G motif; other site
696747008330	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
696747008331	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
696747008332	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
696747008333	putative active site [active]
696747008334	putative substrate binding site [chemical binding]; other site
696747008335	putative cosubstrate binding site; other site
696747008336	catalytic site [active]
696747008337	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696747008338	RNA binding surface [nucleotide binding]; other site
696747008339	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
696747008340	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747008341	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747008342	putative active site [active]
696747008343	putative NTP binding site [chemical binding]; other site
696747008344	putative nucleic acid binding site [nucleotide binding]; other site
696747008345	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747008346	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747008347	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747008348	active site
696747008349	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747008350	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747008351	Homeodomain-like domain; Region: HTH_23; cl17451
696747008352	Winged helix-turn helix; Region: HTH_33; pfam13592
696747008353	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008354	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747008355	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
696747008356	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
696747008357	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747008359	Winged helix-turn helix; Region: HTH_29; pfam13551
696747008360	Winged helix-turn helix; Region: HTH_33; pfam13592
696747008361	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008362	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747008363	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747008364	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747008365	putative NTP binding site [chemical binding]; other site
696747008366	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747008367	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747008368	putative active site [active]
696747008369	putative nucleic acid binding site [nucleotide binding]; other site
696747008370	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747008371	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747008372	active site
696747008373	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
696747008374	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
696747008375	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
696747008376	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747008377	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
696747008378	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747008379	Winged helix-turn helix; Region: HTH_33; pfam13592
696747008380	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008381	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747008382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747008383	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008384	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
696747008385	active site
696747008386	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747008387	Homeodomain-like domain; Region: HTH_23; cl17451
696747008388	Winged helix-turn helix; Region: HTH_33; pfam13592
696747008389	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008390	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008391	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747008392	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
696747008393	dimer interface [polypeptide binding]; other site
696747008394	[2Fe-2S] cluster binding site [ion binding]; other site
696747008395	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747008396	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747008397	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747008398	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747008399	putative NTP binding site [chemical binding]; other site
696747008400	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747008401	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747008402	putative active site [active]
696747008403	putative nucleic acid binding site [nucleotide binding]; other site
696747008404	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747008405	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747008406	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747008407	active site
696747008408	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747008409	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747008410	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747008411	NTP binding site [chemical binding]; other site
696747008412	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747008413	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747008414	putative active site [active]
696747008415	putative nucleic acid binding site [nucleotide binding]; other site
696747008416	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747008417	Probable transposase; Region: OrfB_IS605; pfam01385
696747008418	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747008419	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747008420	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008421	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747008422	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
696747008423	Helix-turn-helix domain; Region: HTH_28; pfam13518
696747008424	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008425	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747008426	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747008427	Homeodomain-like domain; Region: HTH_23; pfam13384
696747008428	Winged helix-turn helix; Region: HTH_33; pfam13592
696747008429	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008430	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747008431	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008432	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747008433	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747008434	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747008435	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747008436	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747008437	active site
696747008438	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
696747008439	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747008440	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747008441	putative active site [active]
696747008442	putative nucleic acid binding site [nucleotide binding]; other site
696747008443	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747008444	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747008445	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747008446	active site
696747008447	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747008448	putative NTP binding site [chemical binding]; other site
696747008449	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747008450	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747008451	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747008452	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747008453	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747008454	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747008455	active site
696747008456	ATP binding site [chemical binding]; other site
696747008457	substrate binding site [chemical binding]; other site
696747008458	activation loop (A-loop); other site
696747008459	GUN4-like; Region: GUN4; pfam05419
696747008460	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008461	TPR motif; other site
696747008462	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747008463	binding surface
696747008464	TPR repeat; Region: TPR_11; pfam13414
696747008465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008466	TPR motif; other site
696747008467	binding surface
696747008468	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008469	binding surface
696747008470	TPR repeat; Region: TPR_11; pfam13414
696747008471	TPR motif; other site
696747008472	TPR repeat; Region: TPR_11; pfam13414
696747008473	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008474	binding surface
696747008475	TPR motif; other site
696747008476	TPR repeat; Region: TPR_11; pfam13414
696747008477	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696747008478	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747008479	S-adenosylmethionine binding site [chemical binding]; other site
696747008480	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
696747008481	ABC1 family; Region: ABC1; cl17513
696747008482	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
696747008483	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
696747008484	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
696747008485	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
696747008486	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
696747008487	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
696747008488	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
696747008489	16S/18S rRNA binding site [nucleotide binding]; other site
696747008490	S13e-L30e interaction site [polypeptide binding]; other site
696747008491	25S rRNA binding site [nucleotide binding]; other site
696747008492	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
696747008493	Mechanosensitive ion channel; Region: MS_channel; pfam00924
696747008494	Mechanosensitive ion channel; Region: MS_channel; pfam00924
696747008495	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
696747008496	CHAT domain; Region: CHAT; pfam12770
696747008497	Mechanosensitive ion channel; Region: MS_channel; pfam00924
696747008498	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
696747008499	catalytic core [active]
696747008500	hypothetical protein; Validated; Region: PRK00110
696747008501	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
696747008502	catalytic motif [active]
696747008503	Catalytic residue [active]
696747008504	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
696747008505	catalytic motif [active]
696747008506	Catalytic residue [active]
696747008507	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
696747008508	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747008509	putative active site [active]
696747008510	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747008511	putative active site [active]
696747008512	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747008513	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747008514	active site
696747008515	ATP binding site [chemical binding]; other site
696747008516	substrate binding site [chemical binding]; other site
696747008517	activation loop (A-loop); other site
696747008518	methionine sulfoxide reductase A; Provisional; Region: PRK00058
696747008519	Predicted methyltransferases [General function prediction only]; Region: COG0313
696747008520	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
696747008521	putative SAM binding site [chemical binding]; other site
696747008522	putative homodimer interface [polypeptide binding]; other site
696747008523	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
696747008524	FtsH protease regulator HflC; Provisional; Region: PRK11029
696747008525	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
696747008526	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
696747008527	active site
696747008528	catalytic triad [active]
696747008529	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
696747008530	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
696747008531	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
696747008532	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
696747008533	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
696747008534	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747008535	Walker A/P-loop; other site
696747008536	ATP binding site [chemical binding]; other site
696747008537	Q-loop/lid; other site
696747008538	ABC transporter signature motif; other site
696747008539	Walker B; other site
696747008540	D-loop; other site
696747008541	H-loop/switch region; other site
696747008542	TOBE domain; Region: TOBE_2; pfam08402
696747008543	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
696747008544	imidazolonepropionase; Provisional; Region: PRK14085
696747008545	Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777
696747008546	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747008547	G4 box; other site
696747008548	G5 box; other site
696747008549	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
696747008550	active site
696747008551	catalytic residues [active]
696747008552	DNA binding site [nucleotide binding]
696747008553	Int/Topo IB signature motif; other site
696747008554	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
696747008555	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
696747008556	catalytic residues [active]
696747008557	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747008558	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
696747008559	dimer interface [polypeptide binding]; other site
696747008560	putative anticodon binding site; other site
696747008561	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
696747008562	motif 1; other site
696747008563	dimer interface [polypeptide binding]; other site
696747008564	active site
696747008565	motif 2; other site
696747008566	Bacterial SH3 domain homologues; Region: SH3b; smart00287
696747008567	HEAT repeats; Region: HEAT_2; pfam13646
696747008568	HEAT repeats; Region: HEAT_2; pfam13646
696747008569	HEAT repeats; Region: HEAT_2; pfam13646
696747008570	HEAT repeats; Region: HEAT_2; pfam13646
696747008571	HEAT repeats; Region: HEAT_2; pfam13646
696747008572	HEAT repeats; Region: HEAT_2; pfam13646
696747008573	HEAT repeats; Region: HEAT_2; pfam13646
696747008574	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
696747008575	CHAT domain; Region: CHAT; pfam12770
696747008576	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008577	binding surface
696747008578	TPR repeat; Region: TPR_11; pfam13414
696747008579	TPR motif; other site
696747008580	TPR repeat; Region: TPR_11; pfam13414
696747008581	Putative restriction endonuclease; Region: Uma2; pfam05685
696747008582	putative active site [active]
696747008583	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747008584	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
696747008585	cofactor binding site; other site
696747008586	DNA binding site [nucleotide binding]
696747008587	substrate interaction site [chemical binding]; other site
696747008588	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747008589	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
696747008590	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
696747008591	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
696747008592	light-harvesting-like protein 3; Provisional; Region: PLN00014
696747008593	FeoA domain; Region: FeoA; pfam04023
696747008594	FeoA domain; Region: FeoA; pfam04023
696747008595	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
696747008596	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
696747008597	G1 box; other site
696747008598	GTP/Mg2+ binding site [chemical binding]; other site
696747008599	Switch I region; other site
696747008600	G2 box; other site
696747008601	G3 box; other site
696747008602	Switch II region; other site
696747008603	G4 box; other site
696747008604	G5 box; other site
696747008605	Nucleoside recognition; Region: Gate; pfam07670
696747008606	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
696747008607	FeoC like transcriptional regulator; Region: FeoC; pfam09012
696747008608	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048
696747008609	diiron binding motif [ion binding]; other site
696747008610	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
696747008611	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696747008612	Soluble P-type ATPase [General function prediction only]; Region: COG4087
696747008613	Fatty acid desaturase; Region: FA_desaturase; pfam00487
696747008614	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
696747008615	putative di-iron ligands [ion binding]; other site
696747008616	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
696747008617	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
696747008618	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
696747008619	Walker A/P-loop; other site
696747008620	ATP binding site [chemical binding]; other site
696747008621	Q-loop/lid; other site
696747008622	ABC transporter signature motif; other site
696747008623	Walker B; other site
696747008624	D-loop; other site
696747008625	H-loop/switch region; other site
696747008626	TOBE domain; Region: TOBE_2; pfam08402
696747008627	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
696747008628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747008629	conserved gate region; other site
696747008630	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747008631	putative PBP binding loops; other site
696747008632	dimer interface [polypeptide binding]; other site
696747008633	ABC-ATPase subunit interface; other site
696747008634	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
696747008635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747008636	dimer interface [polypeptide binding]; other site
696747008637	conserved gate region; other site
696747008638	putative PBP binding loops; other site
696747008639	ABC-ATPase subunit interface; other site
696747008640	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
696747008641	active site
696747008642	dimer interface [polypeptide binding]; other site
696747008643	metal binding site [ion binding]; metal-binding site
696747008644	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
696747008645	Protein of unknown function (DUF497); Region: DUF497; pfam04365
696747008646	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
696747008647	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
696747008648	quinone interaction residues [chemical binding]; other site
696747008649	active site
696747008650	catalytic residues [active]
696747008651	FMN binding site [chemical binding]; other site
696747008652	substrate binding site [chemical binding]; other site
696747008653	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
696747008654	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
696747008655	Walker A/P-loop; other site
696747008656	ATP binding site [chemical binding]; other site
696747008657	Q-loop/lid; other site
696747008658	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
696747008659	ABC transporter signature motif; other site
696747008660	Walker B; other site
696747008661	D-loop; other site
696747008662	H-loop/switch region; other site
696747008663	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
696747008664	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
696747008665	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742
696747008666	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742
696747008667	CRISPR-associated protein; Region: TIGR03986
696747008668	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
696747008669	CRISPR-associated protein, TIGR03984 family; Region: TIGR03984
696747008670	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
696747008671	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
696747008672	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
696747008673	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
696747008674	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
696747008675	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747008676	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747008677	active site
696747008678	ATP binding site [chemical binding]; other site
696747008679	substrate binding site [chemical binding]; other site
696747008680	activation loop (A-loop); other site
696747008681	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008682	TPR motif; other site
696747008683	TPR repeat; Region: TPR_11; pfam13414
696747008684	binding surface
696747008685	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008686	binding surface
696747008687	TPR motif; other site
696747008688	TPR repeat; Region: TPR_11; pfam13414
696747008689	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
696747008690	substrate binding site [chemical binding]; other site
696747008691	activation loop (A-loop); other site
696747008692	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
696747008693	active site
696747008694	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
696747008695	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747008696	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747008697	phosphopeptide binding site; other site
696747008698	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
696747008699	metal ion-dependent adhesion site (MIDAS); other site
696747008700	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
696747008701	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
696747008702	metal ion-dependent adhesion site (MIDAS); other site
696747008703	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
696747008704	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
696747008705	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
696747008706	metal ion-dependent adhesion site (MIDAS); other site
696747008707	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
696747008708	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
696747008709	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732
696747008710	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439
696747008711	Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040
696747008712	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
696747008713	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
696747008714	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
696747008715	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647
696747008716	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
696747008717	Family of unknown function (DUF490); Region: DUF490; pfam04357
696747008718	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747008719	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008720	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008721	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008722	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008723	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
696747008724	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
696747008725	putative active site [active]
696747008726	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
696747008727	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149
696747008728	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
696747008729	excinuclease ABC subunit B; Provisional; Region: PRK05298
696747008730	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747008731	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747008732	nucleotide binding region [chemical binding]; other site
696747008733	ATP-binding site [chemical binding]; other site
696747008734	Ultra-violet resistance protein B; Region: UvrB; pfam12344
696747008735	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
696747008736	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
696747008737	active site
696747008738	Zn binding site [ion binding]; other site
696747008739	DNA gyrase subunit A; Validated; Region: PRK05560
696747008740	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
696747008741	CAP-like domain; other site
696747008742	active site
696747008743	primary dimer interface [polypeptide binding]; other site
696747008744	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696747008745	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696747008746	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696747008747	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696747008748	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696747008749	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696747008750	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
696747008751	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
696747008752	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
696747008753	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
696747008754	oligomerization interface [polypeptide binding]; other site
696747008755	active site
696747008756	metal binding site [ion binding]; metal-binding site
696747008757	aromatic acid decarboxylase; Validated; Region: PRK05920
696747008758	Flavoprotein; Region: Flavoprotein; pfam02441
696747008759	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
696747008760	shikimate kinase; Reviewed; Region: aroK; PRK00131
696747008761	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
696747008762	ADP binding site [chemical binding]; other site
696747008763	magnesium binding site [ion binding]; other site
696747008764	putative shikimate binding site; other site
696747008765	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
696747008766	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747008767	ATP binding site [chemical binding]; other site
696747008768	putative Mg++ binding site [ion binding]; other site
696747008769	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747008770	nucleotide binding region [chemical binding]; other site
696747008771	ATP-binding site [chemical binding]; other site
696747008772	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
696747008773	HRDC domain; Region: HRDC; pfam00570
696747008774	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747008775	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008776	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008777	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008778	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008779	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008780	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008781	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
696747008782	putative hexamer interface [polypeptide binding]; other site
696747008783	putative hexagonal pore; other site
696747008784	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
696747008785	Hexamer interface [polypeptide binding]; other site
696747008786	Hexagonal pore residue; other site
696747008787	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
696747008788	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
696747008789	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
696747008790	putative active site [active]
696747008791	putative metal binding site [ion binding]; other site
696747008792	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
696747008793	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747008794	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747008795	Probable transposase; Region: OrfB_IS605; pfam01385
696747008796	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747008797	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
696747008798	putative active site [active]
696747008799	catalytic residue [active]
696747008800	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
696747008801	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
696747008802	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
696747008803	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
696747008804	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
696747008805	Tetramer interface [polypeptide binding]; other site
696747008806	active site
696747008807	FMN-binding site [chemical binding]; other site
696747008808	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
696747008809	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747008810	GAF domain; Region: GAF; pfam01590
696747008811	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747008812	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747008813	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747008814	dimer interface [polypeptide binding]; other site
696747008815	phosphorylation site [posttranslational modification]
696747008816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747008817	ATP binding site [chemical binding]; other site
696747008818	Mg2+ binding site [ion binding]; other site
696747008819	G-X-G motif; other site
696747008820	Response regulator receiver domain; Region: Response_reg; pfam00072
696747008821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747008822	active site
696747008823	phosphorylation site [posttranslational modification]
696747008824	intermolecular recognition site; other site
696747008825	dimerization interface [polypeptide binding]; other site
696747008826	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
696747008827	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696747008828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747008829	active site
696747008830	phosphorylation site [posttranslational modification]
696747008831	intermolecular recognition site; other site
696747008832	dimerization interface [polypeptide binding]; other site
696747008833	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747008834	DNA binding site [nucleotide binding]
696747008835	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
696747008836	S-layer homology domain; Region: SLH; pfam00395
696747008837	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
696747008838	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747008839	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747008840	active site
696747008841	ATP binding site [chemical binding]; other site
696747008842	substrate binding site [chemical binding]; other site
696747008843	activation loop (A-loop); other site
696747008844	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747008845	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747008846	structural tetrad; other site
696747008847	Transposase IS200 like; Region: Y1_Tnp; pfam01797
696747008848	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747008849	Probable transposase; Region: OrfB_IS605; pfam01385
696747008850	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747008851	calcium/proton exchanger (cax); Region: cax; TIGR00378
696747008852	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
696747008853	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
696747008854	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
696747008855	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
696747008856	nucleotide binding pocket [chemical binding]; other site
696747008857	K-X-D-G motif; other site
696747008858	catalytic site [active]
696747008859	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
696747008860	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
696747008861	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
696747008862	Dimer interface [polypeptide binding]; other site
696747008863	BRCT sequence motif; other site
696747008864	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
696747008865	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
696747008866	Protein of unknown function (DUF444); Region: DUF444; cl17371
696747008867	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
696747008868	metal ion-dependent adhesion site (MIDAS); other site
696747008869	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747008870	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008871	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008872	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747008873	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
696747008874	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696747008875	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747008876	Walker A/P-loop; other site
696747008877	ATP binding site [chemical binding]; other site
696747008878	Q-loop/lid; other site
696747008879	ABC transporter signature motif; other site
696747008880	Walker B; other site
696747008881	D-loop; other site
696747008882	H-loop/switch region; other site
696747008883	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
696747008884	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
696747008885	classical (c) SDRs; Region: SDR_c; cd05233
696747008886	NAD(P) binding site [chemical binding]; other site
696747008887	active site
696747008888	Winged helix-turn helix; Region: HTH_29; pfam13551
696747008889	Homeodomain-like domain; Region: HTH_23; cl17451
696747008890	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008891	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747008892	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
696747008893	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
696747008894	HSP70 interaction site [polypeptide binding]; other site
696747008895	Clp protease; Region: CLP_protease; pfam00574
696747008896	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
696747008897	oligomer interface [polypeptide binding]; other site
696747008898	active site residues [active]
696747008899	Clp protease; Region: CLP_protease; pfam00574
696747008900	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
696747008901	oligomer interface [polypeptide binding]; other site
696747008902	active site residues [active]
696747008903	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
696747008904	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
696747008905	oligomer interface [polypeptide binding]; other site
696747008906	active site residues [active]
696747008907	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
696747008908	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
696747008909	metal ion-dependent adhesion site (MIDAS); other site
696747008910	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
696747008911	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
696747008912	catalytic site [active]
696747008913	G-X2-G-X-G-K; other site
696747008914	hypothetical protein; Provisional; Region: PRK04323
696747008915	Winged helix-turn helix; Region: HTH_29; pfam13551
696747008916	Homeodomain-like domain; Region: HTH_23; cl17451
696747008917	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696747008918	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747008919	active site
696747008920	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696747008921	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
696747008922	Phage tail repeat like; Region: PTR; pfam12789
696747008923	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747008924	TPR repeat; Region: TPR_11; pfam13414
696747008925	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008926	binding surface
696747008927	TPR motif; other site
696747008928	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747008929	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008930	binding surface
696747008931	TPR motif; other site
696747008932	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008933	binding surface
696747008934	TPR motif; other site
696747008935	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008936	binding surface
696747008937	TPR motif; other site
696747008938	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747008939	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008940	binding surface
696747008941	TPR motif; other site
696747008942	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008943	binding surface
696747008944	TPR motif; other site
696747008945	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008946	binding surface
696747008947	TPR motif; other site
696747008948	TPR repeat; Region: TPR_11; pfam13414
696747008949	CHAT domain; Region: CHAT; pfam12770
696747008950	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008951	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747008952	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747008953	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747008954	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747008955	putative active site [active]
696747008956	putative NTP binding site [chemical binding]; other site
696747008957	putative nucleic acid binding site [nucleotide binding]; other site
696747008958	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747008959	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747008960	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747008961	active site
696747008962	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747008963	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747008964	active site
696747008965	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
696747008966	MarR family; Region: MarR_2; cl17246
696747008967	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
696747008968	active site
696747008969	catalytic residues [active]
696747008970	DNA binding site [nucleotide binding]
696747008971	Int/Topo IB signature motif; other site
696747008972	Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777
696747008973	imidazolonepropionase; Provisional; Region: PRK14085
696747008974	Winged helix-turn helix; Region: HTH_29; pfam13551
696747008975	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747008976	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747008977	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747008978	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747008979	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
696747008980	DNA binding residues [nucleotide binding]
696747008981	HEAT repeats; Region: HEAT_2; pfam13646
696747008982	HEAT repeats; Region: HEAT_2; pfam13646
696747008983	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
696747008984	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747008985	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747008986	active site
696747008987	ATP binding site [chemical binding]; other site
696747008988	substrate binding site [chemical binding]; other site
696747008989	activation loop (A-loop); other site
696747008990	TPR repeat; Region: TPR_11; pfam13414
696747008991	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008992	binding surface
696747008993	TPR motif; other site
696747008994	TPR repeat; Region: TPR_11; pfam13414
696747008995	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747008996	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747008997	binding surface
696747008998	TPR motif; other site
696747008999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009000	binding surface
696747009001	TPR motif; other site
696747009002	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009003	binding surface
696747009004	TPR motif; other site
696747009005	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009006	TPR repeat; Region: TPR_11; pfam13414
696747009007	binding surface
696747009008	TPR motif; other site
696747009009	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
696747009010	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
696747009011	tandem repeat interface [polypeptide binding]; other site
696747009012	oligomer interface [polypeptide binding]; other site
696747009013	active site residues [active]
696747009014	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
696747009015	tandem repeat interface [polypeptide binding]; other site
696747009016	oligomer interface [polypeptide binding]; other site
696747009017	active site residues [active]
696747009018	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
696747009019	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
696747009020	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747009021	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009022	binding surface
696747009023	TPR motif; other site
696747009024	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747009025	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009026	binding surface
696747009027	TPR motif; other site
696747009028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009029	binding surface
696747009030	TPR motif; other site
696747009031	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009032	binding surface
696747009033	TPR motif; other site
696747009034	Protein of unknown function (DUF563); Region: DUF563; pfam04577
696747009035	TPR repeat; Region: TPR_11; pfam13414
696747009036	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009037	TPR motif; other site
696747009038	TPR repeat; Region: TPR_11; pfam13414
696747009039	binding surface
696747009040	TPR repeat; Region: TPR_11; pfam13414
696747009041	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009042	binding surface
696747009043	TPR motif; other site
696747009044	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009045	binding surface
696747009046	TPR motif; other site
696747009047	TPR repeat; Region: TPR_11; pfam13414
696747009048	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009049	binding surface
696747009050	TPR motif; other site
696747009051	TPR repeat; Region: TPR_11; pfam13414
696747009052	TPR repeat; Region: TPR_11; pfam13414
696747009053	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009054	binding surface
696747009055	TPR motif; other site
696747009056	TPR repeat; Region: TPR_11; pfam13414
696747009057	TPR repeat; Region: TPR_11; pfam13414
696747009058	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009059	binding surface
696747009060	TPR motif; other site
696747009061	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747009062	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009063	binding surface
696747009064	TPR motif; other site
696747009065	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009066	binding surface
696747009067	TPR motif; other site
696747009068	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009069	TPR motif; other site
696747009070	binding surface
696747009071	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
696747009072	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
696747009073	Probable Catalytic site; other site
696747009074	metal-binding site
696747009075	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747009076	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
696747009077	Probable Catalytic site; other site
696747009078	metal-binding site
696747009079	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
696747009080	Transposase IS200 like; Region: Y1_Tnp; pfam01797
696747009081	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
696747009082	IHF dimer interface [polypeptide binding]; other site
696747009083	IHF - DNA interface [nucleotide binding]; other site
696747009084	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
696747009085	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
696747009086	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
696747009087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
696747009088	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696747009089	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747009090	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747009091	Methyltransferase domain; Region: Methyltransf_12; pfam08242
696747009092	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747009093	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696747009094	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747009095	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009096	binding surface
696747009097	TPR motif; other site
696747009098	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747009099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009100	binding surface
696747009101	TPR motif; other site
696747009102	TPR repeat; Region: TPR_11; pfam13414
696747009103	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009104	binding surface
696747009105	TPR motif; other site
696747009106	TPR repeat; Region: TPR_11; pfam13414
696747009107	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009108	binding surface
696747009109	TPR motif; other site
696747009110	TPR repeat; Region: TPR_11; pfam13414
696747009111	TPR repeat; Region: TPR_11; pfam13414
696747009112	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009113	binding surface
696747009114	TPR motif; other site
696747009115	TPR repeat; Region: TPR_11; pfam13414
696747009116	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009117	TPR repeat; Region: TPR_11; pfam13414
696747009118	TPR motif; other site
696747009119	binding surface
696747009120	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
696747009121	nucleoside/Zn binding site; other site
696747009122	dimer interface [polypeptide binding]; other site
696747009123	catalytic motif [active]
696747009124	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
696747009125	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
696747009126	putative acyl-acceptor binding pocket; other site
696747009127	Helix-turn-helix domain; Region: HTH_18; pfam12833
696747009128	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
696747009129	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696747009130	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747009131	homodimer interface [polypeptide binding]; other site
696747009132	catalytic residue [active]
696747009133	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
696747009134	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
696747009135	B12 binding site [chemical binding]; other site
696747009136	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747009137	FeS/SAM binding site; other site
696747009138	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
696747009139	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
696747009140	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
696747009141	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
696747009142	homodimer interface [polypeptide binding]; other site
696747009143	oligonucleotide binding site [chemical binding]; other site
696747009144	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
696747009145	RNA/DNA hybrid binding site [nucleotide binding]; other site
696747009146	active site
696747009147	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
696747009148	prephenate dehydratase; Provisional; Region: PRK11898
696747009149	Prephenate dehydratase; Region: PDT; pfam00800
696747009150	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
696747009151	putative L-Phe binding site [chemical binding]; other site
696747009152	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
696747009153	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
696747009154	elongation factor Tu; Region: tufA; CHL00071
696747009155	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
696747009156	G1 box; other site
696747009157	GEF interaction site [polypeptide binding]; other site
696747009158	GTP/Mg2+ binding site [chemical binding]; other site
696747009159	Switch I region; other site
696747009160	G2 box; other site
696747009161	G3 box; other site
696747009162	Switch II region; other site
696747009163	G4 box; other site
696747009164	G5 box; other site
696747009165	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
696747009166	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
696747009167	Antibiotic Binding Site [chemical binding]; other site
696747009168	elongation factor G; Reviewed; Region: PRK00007
696747009169	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
696747009170	G1 box; other site
696747009171	putative GEF interaction site [polypeptide binding]; other site
696747009172	GTP/Mg2+ binding site [chemical binding]; other site
696747009173	Switch I region; other site
696747009174	G2 box; other site
696747009175	G3 box; other site
696747009176	Switch II region; other site
696747009177	G4 box; other site
696747009178	G5 box; other site
696747009179	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
696747009180	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
696747009181	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
696747009182	30S ribosomal protein S7; Validated; Region: PRK05302
696747009183	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
696747009184	S17 interaction site [polypeptide binding]; other site
696747009185	S8 interaction site; other site
696747009186	16S rRNA interaction site [nucleotide binding]; other site
696747009187	streptomycin interaction site [chemical binding]; other site
696747009188	23S rRNA interaction site [nucleotide binding]; other site
696747009189	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
696747009190	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
696747009191	Cupin domain; Region: Cupin_2; cl17218
696747009192	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
696747009193	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
696747009194	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
696747009195	active site
696747009196	dimer interface [polypeptide binding]; other site
696747009197	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
696747009198	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
696747009199	active site
696747009200	FMN binding site [chemical binding]; other site
696747009201	substrate binding site [chemical binding]; other site
696747009202	3Fe-4S cluster binding site [ion binding]; other site
696747009203	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
696747009204	domain interface; other site
696747009205	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
696747009206	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
696747009207	Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632
696747009208	putative inhibitory loop; other site
696747009209	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747009210	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747009211	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
696747009212	ParB-like nuclease domain; Region: ParB; smart00470
696747009213	FHA domain; Region: FHA; pfam00498
696747009214	phosphopeptide binding site; other site
696747009215	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747009216	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747009217	phosphopeptide binding site; other site
696747009218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747009219	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
696747009220	Walker A/P-loop; other site
696747009221	ATP binding site [chemical binding]; other site
696747009222	Q-loop/lid; other site
696747009223	ABC transporter signature motif; other site
696747009224	Walker B; other site
696747009225	D-loop; other site
696747009226	H-loop/switch region; other site
696747009227	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
696747009228	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747009229	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747009230	active site
696747009231	ATP binding site [chemical binding]; other site
696747009232	substrate binding site [chemical binding]; other site
696747009233	activation loop (A-loop); other site
696747009234	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
696747009235	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
696747009236	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
696747009237	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
696747009238	diphthine synthase; Region: dph5; TIGR00522
696747009239	active site
696747009240	SAM binding site [chemical binding]; other site
696747009241	homodimer interface [polypeptide binding]; other site
696747009242	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
696747009243	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
696747009244	active site
696747009245	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
696747009246	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747009247	TPR repeat; Region: TPR_11; pfam13414
696747009248	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009249	binding surface
696747009250	TPR motif; other site
696747009251	TPR repeat; Region: TPR_11; pfam13414
696747009252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747009253	active site
696747009254	phosphorylation site [posttranslational modification]
696747009255	intermolecular recognition site; other site
696747009256	dimerization interface [polypeptide binding]; other site
696747009257	PAS domain S-box; Region: sensory_box; TIGR00229
696747009258	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747009259	putative active site [active]
696747009260	heme pocket [chemical binding]; other site
696747009261	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747009262	cyclase homology domain; Region: CHD; cd07302
696747009263	nucleotidyl binding site; other site
696747009264	metal binding site [ion binding]; metal-binding site
696747009265	dimer interface [polypeptide binding]; other site
696747009266	Tetratricopeptide repeat; Region: TPR_2; pfam07719
696747009267	cytochrome c-550; Provisional; Region: psbV; cl17239
696747009268	cytochrome c-550; Region: PS_II_C550; TIGR03045
696747009269	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
696747009270	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
696747009271	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747009272	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
696747009273	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
696747009274	catalytic residues [active]
696747009275	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
696747009276	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
696747009277	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
696747009278	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
696747009279	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
696747009280	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
696747009281	Tropomyosin; Region: Tropomyosin; pfam00261
696747009282	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747009283	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696747009284	active site
696747009285	acetyl-CoA synthetase; Provisional; Region: PRK00174
696747009286	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
696747009287	active site
696747009288	CoA binding site [chemical binding]; other site
696747009289	acyl-activating enzyme (AAE) consensus motif; other site
696747009290	AMP binding site [chemical binding]; other site
696747009291	acetate binding site [chemical binding]; other site
696747009292	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
696747009293	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696747009294	Coenzyme A binding pocket [chemical binding]; other site
696747009295	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747009296	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747009297	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747009298	dimer interface [polypeptide binding]; other site
696747009299	phosphorylation site [posttranslational modification]
696747009300	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747009301	ATP binding site [chemical binding]; other site
696747009302	Mg2+ binding site [ion binding]; other site
696747009303	G-X-G motif; other site
696747009304	Post-segregation antitoxin CcdA; Region: CcdA; cl02188
696747009305	Transglycosylase; Region: Transgly; pfam00912
696747009306	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
696747009307	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
696747009308	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747009309	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747009310	active site
696747009311	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747009312	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009313	putative active site [active]
696747009314	putative NTP binding site [chemical binding]; other site
696747009315	putative nucleic acid binding site [nucleotide binding]; other site
696747009316	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747009317	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747009318	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747009319	active site
696747009320	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
696747009321	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
696747009322	active site
696747009323	DNA binding site [nucleotide binding]
696747009324	Int/Topo IB signature motif; other site
696747009325	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
696747009326	polymerase nucleotide-binding site; other site
696747009327	DNA-binding residues [nucleotide binding]; DNA binding site
696747009328	nucleotide binding site [chemical binding]; other site
696747009329	primase nucleotide-binding site [nucleotide binding]; other site
696747009330	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
696747009331	Virulence-associated protein E; Region: VirE; pfam05272
696747009332	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
696747009333	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
696747009334	Phage tail repeat like; Region: PTR; pfam12789
696747009335	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747009336	TPR repeat; Region: TPR_11; pfam13414
696747009337	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009338	binding surface
696747009339	TPR motif; other site
696747009340	TPR repeat; Region: TPR_11; pfam13414
696747009341	TPR repeat; Region: TPR_11; pfam13414
696747009342	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009343	binding surface
696747009344	TPR motif; other site
696747009345	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696747009346	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
696747009347	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
696747009348	Walker A/P-loop; other site
696747009349	ATP binding site [chemical binding]; other site
696747009350	Q-loop/lid; other site
696747009351	ABC transporter signature motif; other site
696747009352	Walker B; other site
696747009353	D-loop; other site
696747009354	H-loop/switch region; other site
696747009355	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747009356	structural tetrad; other site
696747009357	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747009358	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747009359	structural tetrad; other site
696747009360	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
696747009361	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
696747009362	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
696747009363	Substrate binding site; other site
696747009364	Mg++ binding site; other site
696747009365	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
696747009366	active site
696747009367	substrate binding site [chemical binding]; other site
696747009368	CoA binding site [chemical binding]; other site
696747009369	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
696747009370	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747009371	photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877
696747009372	photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704
696747009373	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
696747009374	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
696747009375	Probable Catalytic site; other site
696747009376	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
696747009377	UreF; Region: UreF; pfam01730
696747009378	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
696747009379	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
696747009380	dimer interface [polypeptide binding]; other site
696747009381	catalytic residues [active]
696747009382	ferrochelatase; Reviewed; Region: hemH; PRK00035
696747009383	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
696747009384	active site
696747009385	C-terminal domain interface [polypeptide binding]; other site
696747009386	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
696747009387	active site
696747009388	N-terminal domain interface [polypeptide binding]; other site
696747009389	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504
696747009390	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747009391	S-adenosylmethionine binding site [chemical binding]; other site
696747009392	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
696747009393	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
696747009394	Predicted ATPase [General function prediction only]; Region: COG4637
696747009395	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747009396	Walker A/P-loop; other site
696747009397	ATP binding site [chemical binding]; other site
696747009398	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
696747009399	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747009400	phosphopeptide binding site; other site
696747009401	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747009402	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747009403	phosphopeptide binding site; other site
696747009404	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
696747009405	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
696747009406	Walker A/P-loop; other site
696747009407	ATP binding site [chemical binding]; other site
696747009408	Q-loop/lid; other site
696747009409	ABC transporter signature motif; other site
696747009410	Walker B; other site
696747009411	D-loop; other site
696747009412	H-loop/switch region; other site
696747009413	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
696747009414	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
696747009415	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
696747009416	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
696747009417	putative active site [active]
696747009418	Double zinc ribbon; Region: DZR; pfam12773
696747009419	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
696747009420	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
696747009421	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747009422	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747009423	phosphopeptide binding site; other site
696747009424	PRC-barrel domain; Region: PRC; pfam05239
696747009425	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
696747009426	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747009427	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747009428	phosphopeptide binding site; other site
696747009429	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
696747009430	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
696747009431	Uncharacterized small protein [Function unknown]; Region: COG2886
696747009432	DnaJ domain; Region: DnaJ; pfam00226
696747009433	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747009434	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747009435	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009436	binding surface
696747009437	TPR motif; other site
696747009438	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747009439	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747009440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009441	binding surface
696747009442	TPR motif; other site
696747009443	TPR repeat; Region: TPR_11; pfam13414
696747009444	CHAT domain; Region: CHAT; pfam12770
696747009445	PIN domain; Region: PIN; pfam01850
696747009446	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
696747009447	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
696747009448	putative active site [active]
696747009449	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
696747009450	putative active site [active]
696747009451	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
696747009452	putative active site [active]
696747009453	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009454	binding surface
696747009455	TPR motif; other site
696747009456	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009457	TPR motif; other site
696747009458	binding surface
696747009459	CHAT domain; Region: CHAT; pfam12770
696747009460	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747009461	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747009462	Protein of unknown function (DUF433); Region: DUF433; cl01030
696747009463	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
696747009464	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
696747009465	HEAT repeats; Region: HEAT_2; pfam13646
696747009466	HEAT repeats; Region: HEAT_2; pfam13646
696747009467	HEAT repeats; Region: HEAT_2; pfam13646
696747009468	HEAT repeats; Region: HEAT_2; pfam13646
696747009469	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
696747009470	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747009471	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747009472	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747009473	active site
696747009474	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009475	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747009476	putative nucleic acid binding site [nucleotide binding]; other site
696747009477	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009478	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747009479	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747009480	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747009481	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747009482	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009483	putative active site [active]
696747009484	putative NTP binding site [chemical binding]; other site
696747009485	putative nucleic acid binding site [nucleotide binding]; other site
696747009486	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747009487	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747009488	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747009489	active site
696747009490	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
696747009491	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
696747009492	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
696747009493	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747009494	ATP binding site [chemical binding]; other site
696747009495	putative Mg++ binding site [ion binding]; other site
696747009496	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
696747009497	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
696747009498	putative active site [active]
696747009499	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
696747009500	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
696747009501	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
696747009502	HsdM N-terminal domain; Region: HsdM_N; pfam12161
696747009503	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747009504	S-adenosylmethionine binding site [chemical binding]; other site
696747009505	PemK-like protein; Region: PemK; pfam02452
696747009506	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
696747009507	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
696747009508	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
696747009509	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
696747009510	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
696747009511	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
696747009512	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
696747009513	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
696747009514	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747009515	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747009516	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747009517	putative active site [active]
696747009518	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747009519	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747009520	Winged helix-turn helix; Region: HTH_29; pfam13551
696747009521	Homeodomain-like domain; Region: HTH_23; cl17451
696747009522	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747009523	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009524	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747009525	putative active site [active]
696747009526	putative nucleic acid binding site [nucleotide binding]; other site
696747009527	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747009528	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747009529	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747009530	active site
696747009531	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009532	putative NTP binding site [chemical binding]; other site
696747009533	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747009534	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747009535	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
696747009536	lipoyl synthase; Provisional; Region: PRK05481
696747009537	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009538	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747009539	putative active site [active]
696747009540	putative nucleic acid binding site [nucleotide binding]; other site
696747009541	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747009542	Winged helix-turn helix; Region: HTH_29; pfam13551
696747009543	Homeodomain-like domain; Region: HTH_23; cl17451
696747009544	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747009545	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747009546	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747009547	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747009548	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009549	Domain of unknown function (DUF927); Region: DUF927; cl12098
696747009550	Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
696747009551	Protein of unknown function (DUF1347); Region: DUF1347; pfam07079
696747009552	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009553	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747009554	putative active site [active]
696747009555	putative nucleic acid binding site [nucleotide binding]; other site
696747009556	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747009557	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747009558	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747009559	active site
696747009560	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009561	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747009562	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747009563	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747009564	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747009565	Helix-turn-helix domain; Region: HTH_28; pfam13518
696747009566	Winged helix-turn helix; Region: HTH_33; pfam13592
696747009567	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747009568	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747009569	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747009570	Homeodomain-like domain; Region: HTH_23; cl17451
696747009571	Winged helix-turn helix; Region: HTH_33; pfam13592
696747009572	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747009573	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747009574	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747009575	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009576	putative NTP binding site [chemical binding]; other site
696747009577	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009578	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747009579	putative active site [active]
696747009580	putative nucleic acid binding site [nucleotide binding]; other site
696747009581	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747009582	Winged helix-turn helix; Region: HTH_33; pfam13592
696747009583	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747009584	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747009585	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747009586	Fragile site-associated protein C-terminus; Region: FSA_C; pfam10479
696747009587	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
696747009588	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
696747009589	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696747009590	Coenzyme A binding pocket [chemical binding]; other site
696747009591	Winged helix-turn helix; Region: HTH_29; pfam13551
696747009592	Helix-turn-helix domain; Region: HTH_28; pfam13518
696747009593	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747009594	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747009595	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747009596	Winged helix-turn helix; Region: HTH_29; pfam13551
696747009597	Helix-turn-helix domain; Region: HTH_28; pfam13518
696747009598	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009599	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747009600	putative active site [active]
696747009601	putative nucleic acid binding site [nucleotide binding]; other site
696747009602	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747009603	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747009604	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747009605	active site
696747009606	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
696747009607	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
696747009608	catalytic site [active]
696747009609	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
696747009610	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696747009611	Coenzyme A binding pocket [chemical binding]; other site
696747009612	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
696747009613	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747009614	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
696747009615	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
696747009616	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
696747009617	active site
696747009618	substrate binding site [chemical binding]; other site
696747009619	metal binding site [ion binding]; metal-binding site
696747009620	Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304
696747009621	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
696747009622	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
696747009623	PYR/PP interface [polypeptide binding]; other site
696747009624	dimer interface [polypeptide binding]; other site
696747009625	TPP binding site [chemical binding]; other site
696747009626	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
696747009627	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
696747009628	TPP-binding site [chemical binding]; other site
696747009629	dimer interface [polypeptide binding]; other site
696747009630	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
696747009631	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
696747009632	Nitrogen regulatory protein P-II; Region: P-II; smart00938
696747009633	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
696747009634	active site
696747009635	dimerization interface [polypeptide binding]; other site
696747009636	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
696747009637	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
696747009638	Predicted GTPase [General function prediction only]; Region: COG3596
696747009639	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747009640	YfjP GTPase; Region: YfjP; cd11383
696747009641	G1 box; other site
696747009642	Walker A/P-loop; other site
696747009643	GTP/Mg2+ binding site [chemical binding]; other site
696747009644	ATP binding site [chemical binding]; other site
696747009645	Switch I region; other site
696747009646	G2 box; other site
696747009647	Switch II region; other site
696747009648	G3 box; other site
696747009649	G4 box; other site
696747009650	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
696747009651	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
696747009652	catalytic residues [active]
696747009653	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
696747009654	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
696747009655	active site
696747009656	metal binding site [ion binding]; metal-binding site
696747009657	DNA binding site [nucleotide binding]
696747009658	hypothetical protein; Validated; Region: PRK07411
696747009659	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
696747009660	ATP binding site [chemical binding]; other site
696747009661	substrate interface [chemical binding]; other site
696747009662	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
696747009663	active site residue [active]
696747009664	PAS domain S-box; Region: sensory_box; TIGR00229
696747009665	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747009666	putative active site [active]
696747009667	heme pocket [chemical binding]; other site
696747009668	PAS fold; Region: PAS_4; pfam08448
696747009669	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747009670	putative active site [active]
696747009671	heme pocket [chemical binding]; other site
696747009672	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747009673	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
696747009674	putative active site [active]
696747009675	heme pocket [chemical binding]; other site
696747009676	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747009677	dimer interface [polypeptide binding]; other site
696747009678	phosphorylation site [posttranslational modification]
696747009679	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747009680	ATP binding site [chemical binding]; other site
696747009681	Mg2+ binding site [ion binding]; other site
696747009682	G-X-G motif; other site
696747009683	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747009684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747009685	active site
696747009686	phosphorylation site [posttranslational modification]
696747009687	intermolecular recognition site; other site
696747009688	dimerization interface [polypeptide binding]; other site
696747009689	Response regulator receiver domain; Region: Response_reg; pfam00072
696747009690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747009691	active site
696747009692	phosphorylation site [posttranslational modification]
696747009693	intermolecular recognition site; other site
696747009694	dimerization interface [polypeptide binding]; other site
696747009695	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747009696	dimer interface [polypeptide binding]; other site
696747009697	phosphorylation site [posttranslational modification]
696747009698	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747009699	ATP binding site [chemical binding]; other site
696747009700	Mg2+ binding site [ion binding]; other site
696747009701	G-X-G motif; other site
696747009702	Peptidase family M48; Region: Peptidase_M48; pfam01435
696747009703	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747009704	AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271
696747009705	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
696747009706	Predicted membrane protein [Function unknown]; Region: COG2119
696747009707	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
696747009708	Predicted membrane protein [Function unknown]; Region: COG2119
696747009709	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
696747009710	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
696747009711	active site
696747009712	NTP binding site [chemical binding]; other site
696747009713	metal binding triad [ion binding]; metal-binding site
696747009714	antibiotic binding site [chemical binding]; other site
696747009715	C-type lectin protein; Provisional; Region: PHA02867
696747009716	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747009717	CHAT domain; Region: CHAT; pfam12770
696747009718	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
696747009719	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
696747009720	putative active site [active]
696747009721	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
696747009722	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
696747009723	oligomeric interface; other site
696747009724	putative active site [active]
696747009725	homodimer interface [polypeptide binding]; other site
696747009726	XisI protein; Region: XisI; pfam08869
696747009727	XisH protein; Region: XisH; pfam08814
696747009728	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
696747009729	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
696747009730	putative active site [active]
696747009731	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
696747009732	putative active site [active]
696747009733	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
696747009734	homodimer interface [polypeptide binding]; other site
696747009735	putative active site [active]
696747009736	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
696747009737	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696747009738	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696747009739	Predicted membrane protein [Function unknown]; Region: COG2259
696747009740	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
696747009741	Predicted transporter component [General function prediction only]; Region: COG2391
696747009742	Sulphur transport; Region: Sulf_transp; pfam04143
696747009743	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
696747009744	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
696747009745	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
696747009746	ligand binding site [chemical binding]; other site
696747009747	NAD binding site [chemical binding]; other site
696747009748	dimerization interface [polypeptide binding]; other site
696747009749	catalytic site [active]
696747009750	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
696747009751	putative L-serine binding site [chemical binding]; other site
696747009752	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
696747009753	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063
696747009754	Calcium binding; Region: Calci_bind_CcbP; pfam11535
696747009755	Protein of unknown function (DUF561); Region: DUF561; pfam04481
696747009756	Creatinine amidohydrolase; Region: Creatininase; pfam02633
696747009757	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747009758	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747009759	active site
696747009760	ATP binding site [chemical binding]; other site
696747009761	substrate binding site [chemical binding]; other site
696747009762	activation loop (A-loop); other site
696747009763	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009764	binding surface
696747009765	TPR motif; other site
696747009766	TPR repeat; Region: TPR_11; pfam13414
696747009767	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009768	binding surface
696747009769	TPR motif; other site
696747009770	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747009771	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009772	binding surface
696747009773	TPR motif; other site
696747009774	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009775	binding surface
696747009776	TPR motif; other site
696747009777	Tetratricopeptide repeat; Region: TPR_9; pfam13371
696747009778	Chitin synthesis regulation, resistance to Congo red; Region: RCR; pfam12273
696747009779	RDD family; Region: RDD; pfam06271
696747009780	HEAT repeats; Region: HEAT_2; pfam13646
696747009781	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747009782	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009783	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009784	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009785	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009786	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009787	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009788	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
696747009789	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
696747009790	inhibitor-cofactor binding pocket; inhibition site
696747009791	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747009792	catalytic residue [active]
696747009793	cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156
696747009794	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
696747009795	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
696747009796	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
696747009797	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
696747009798	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
696747009799	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696747009800	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
696747009801	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
696747009802	Mg binding site [ion binding]; other site
696747009803	nucleotide binding site [chemical binding]; other site
696747009804	putative protofilament interface [polypeptide binding]; other site
696747009805	cell division protein; Validated; Region: ftsH; CHL00176
696747009806	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747009807	Walker A motif; other site
696747009808	ATP binding site [chemical binding]; other site
696747009809	Walker B motif; other site
696747009810	arginine finger; other site
696747009811	Peptidase family M41; Region: Peptidase_M41; pfam01434
696747009812	proline aminopeptidase P II; Provisional; Region: PRK10879
696747009813	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
696747009814	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
696747009815	active site
696747009816	Bacterial SH3 domain; Region: SH3_3; pfam08239
696747009817	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
696747009818	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
696747009819	multimerization interface [polypeptide binding]; other site
696747009820	RbcX protein; Region: RcbX; pfam02341
696747009821	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
696747009822	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
696747009823	homodimer interface [polypeptide binding]; other site
696747009824	active site
696747009825	heterodimer interface [polypeptide binding]; other site
696747009826	catalytic residue [active]
696747009827	metal binding site [ion binding]; metal-binding site
696747009828	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
696747009829	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
696747009830	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
696747009831	putative dimerization interface [polypeptide binding]; other site
696747009832	K-Cl cotransporter; Region: 2a30; TIGR00930
696747009833	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
696747009834	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
696747009835	ketol-acid reductoisomerase; Provisional; Region: PRK05479
696747009836	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
696747009837	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
696747009838	TPR repeat; Region: TPR_11; pfam13414
696747009839	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009840	binding surface
696747009841	TPR motif; other site
696747009842	TPR repeat; Region: TPR_11; pfam13414
696747009843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009844	binding surface
696747009845	TPR motif; other site
696747009846	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747009847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009848	binding surface
696747009849	TPR motif; other site
696747009850	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747009851	binding surface
696747009852	TPR motif; other site
696747009853	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
696747009854	active site
696747009855	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
696747009856	active site
696747009857	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
696747009858	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
696747009859	HSP70 interaction site [polypeptide binding]; other site
696747009860	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
696747009861	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747009862	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009863	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009864	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009865	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009866	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009867	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009868	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
696747009869	protein I interface; other site
696747009870	D2 interface; other site
696747009871	protein T interface; other site
696747009872	chlorophyll binding site; other site
696747009873	beta carotene binding site; other site
696747009874	pheophytin binding site; other site
696747009875	manganese-stabilizing polypeptide interface; other site
696747009876	CP43 interface; other site
696747009877	protein L interface; other site
696747009878	oxygen evolving complex binding site; other site
696747009879	bromide binding site; other site
696747009880	quinone binding site; other site
696747009881	Fe binding site [ion binding]; other site
696747009882	core light harvesting interface; other site
696747009883	cytochrome b559 alpha subunit interface; other site
696747009884	cytochrome c-550 interface; other site
696747009885	protein J interface; other site
696747009886	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747009887	putative active site [active]
696747009888	AAA ATPase domain; Region: AAA_16; pfam13191
696747009889	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747009890	putative active site [active]
696747009891	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
696747009892	protein I interface; other site
696747009893	D2 interface; other site
696747009894	protein T interface; other site
696747009895	chlorophyll binding site; other site
696747009896	beta carotene binding site; other site
696747009897	pheophytin binding site; other site
696747009898	manganese-stabilizing polypeptide interface; other site
696747009899	CP43 interface; other site
696747009900	protein L interface; other site
696747009901	oxygen evolving complex binding site; other site
696747009902	bromide binding site; other site
696747009903	quinone binding site; other site
696747009904	Fe binding site [ion binding]; other site
696747009905	core light harvesting interface; other site
696747009906	cytochrome b559 alpha subunit interface; other site
696747009907	cytochrome c-550 interface; other site
696747009908	protein J interface; other site
696747009909	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
696747009910	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747009911	FeS/SAM binding site; other site
696747009912	Surface antigen [General function prediction only]; Region: COG3942
696747009913	CHAP domain; Region: CHAP; cl17642
696747009914	Bacterial SH3 domain; Region: SH3_3; cl17532
696747009915	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747009916	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747009917	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747009918	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747009919	structural tetrad; other site
696747009920	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747009921	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747009922	structural tetrad; other site
696747009923	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747009924	structural tetrad; other site
696747009925	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
696747009926	NAD(P) binding pocket [chemical binding]; other site
696747009927	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747009928	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747009929	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747009930	putative active site [active]
696747009931	putative NTP binding site [chemical binding]; other site
696747009932	putative nucleic acid binding site [nucleotide binding]; other site
696747009933	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747009934	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
696747009935	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
696747009936	dimer interface [polypeptide binding]; other site
696747009937	ssDNA binding site [nucleotide binding]; other site
696747009938	tetramer (dimer of dimers) interface [polypeptide binding]; other site
696747009939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747009940	Response regulator receiver domain; Region: Response_reg; pfam00072
696747009941	active site
696747009942	phosphorylation site [posttranslational modification]
696747009943	intermolecular recognition site; other site
696747009944	dimerization interface [polypeptide binding]; other site
696747009945	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747009946	GAF domain; Region: GAF; pfam01590
696747009947	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
696747009948	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747009949	S-adenosylmethionine binding site [chemical binding]; other site
696747009950	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
696747009951	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
696747009952	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
696747009953	Nucleoside recognition; Region: Gate; pfam07670
696747009954	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
696747009955	GTP-binding protein Der; Reviewed; Region: PRK00093
696747009956	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
696747009957	G1 box; other site
696747009958	GTP/Mg2+ binding site [chemical binding]; other site
696747009959	Switch I region; other site
696747009960	G2 box; other site
696747009961	Switch II region; other site
696747009962	G3 box; other site
696747009963	G4 box; other site
696747009964	G5 box; other site
696747009965	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
696747009966	G1 box; other site
696747009967	GTP/Mg2+ binding site [chemical binding]; other site
696747009968	Switch I region; other site
696747009969	G2 box; other site
696747009970	G3 box; other site
696747009971	Switch II region; other site
696747009972	G4 box; other site
696747009973	G5 box; other site
696747009974	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
696747009975	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
696747009976	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
696747009977	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
696747009978	catalytic residue [active]
696747009979	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
696747009980	pyrroline-5-carboxylate reductase; Region: PLN02688
696747009981	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
696747009982	membrane protein; Provisional; Region: PRK14419
696747009983	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
696747009984	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
696747009985	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
696747009986	TPP-binding site; other site
696747009987	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
696747009988	PYR/PP interface [polypeptide binding]; other site
696747009989	dimer interface [polypeptide binding]; other site
696747009990	TPP binding site [chemical binding]; other site
696747009991	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
696747009992	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
696747009993	putative metal binding site; other site
696747009994	ribonuclease Y; Region: RNase_Y; TIGR03319
696747009995	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
696747009996	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
696747009997	active site
696747009998	nucleotide binding site [chemical binding]; other site
696747009999	HIGH motif; other site
696747010000	KMSKS motif; other site
696747010001	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
696747010002	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
696747010003	substrate binding site [chemical binding]; other site
696747010004	activation loop (A-loop); other site
696747010005	Protein phosphatase 2C; Region: PP2C_2; pfam13672
696747010006	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
696747010007	metal ion-dependent adhesion site (MIDAS); other site
696747010008	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
696747010009	metal ion-dependent adhesion site (MIDAS); other site
696747010010	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
696747010011	metal ion-dependent adhesion site (MIDAS); other site
696747010012	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
696747010013	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
696747010014	active site
696747010015	nucleotide binding site [chemical binding]; other site
696747010016	HIGH motif; other site
696747010017	KMSKS motif; other site
696747010018	GUN4-like; Region: GUN4; pfam05419
696747010019	Competence protein A; Region: Competence_A; pfam11104
696747010020	Cell division protein FtsA; Region: FtsA; cl17206
696747010021	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
696747010022	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
696747010023	AMIN domain; Region: AMIN; pfam11741
696747010024	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
696747010025	Secretin and TonB N terminus short domain; Region: STN; pfam07660
696747010026	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
696747010027	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
696747010028	IHF dimer interface [polypeptide binding]; other site
696747010029	IHF - DNA interface [nucleotide binding]; other site
696747010030	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
696747010031	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696747010032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747010033	homodimer interface [polypeptide binding]; other site
696747010034	catalytic residue [active]
696747010035	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
696747010036	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
696747010037	GIY-YIG motif/motif A; other site
696747010038	active site
696747010039	catalytic site [active]
696747010040	putative DNA binding site [nucleotide binding]; other site
696747010041	metal binding site [ion binding]; metal-binding site
696747010042	UvrB/uvrC motif; Region: UVR; pfam02151
696747010043	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
696747010044	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
696747010045	Cytochrome P450; Region: p450; pfam00067
696747010046	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
696747010047	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
696747010048	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
696747010049	active site
696747010050	TDP-binding site; other site
696747010051	acceptor substrate-binding pocket; other site
696747010052	homodimer interface [polypeptide binding]; other site
696747010053	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
696747010054	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
696747010055	substrate binding pocket [chemical binding]; other site
696747010056	chain length determination region; other site
696747010057	substrate-Mg2+ binding site; other site
696747010058	catalytic residues [active]
696747010059	aspartate-rich region 1; other site
696747010060	active site lid residues [active]
696747010061	aspartate-rich region 2; other site
696747010062	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010063	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747010064	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010065	Predicted dehydrogenase [General function prediction only]; Region: COG0579
696747010066	hydroxyglutarate oxidase; Provisional; Region: PRK11728
696747010067	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
696747010068	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
696747010069	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
696747010070	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
696747010071	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
696747010072	Peptidase family M48; Region: Peptidase_M48; cl12018
696747010073	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
696747010074	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
696747010075	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696747010076	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747010077	homodimer interface [polypeptide binding]; other site
696747010078	catalytic residue [active]
696747010079	Bacterial SH3 domain; Region: SH3_3; cl17532
696747010080	Ferredoxin [Energy production and conversion]; Region: COG1146
696747010081	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696747010082	Walker A motif; other site
696747010083	ATP binding site [chemical binding]; other site
696747010084	DNA repair protein RadA; Provisional; Region: PRK11823
696747010085	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696747010086	Walker B motif; other site
696747010087	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
696747010088	Ycf27; Reviewed; Region: orf27; CHL00148
696747010089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747010090	active site
696747010091	phosphorylation site [posttranslational modification]
696747010092	intermolecular recognition site; other site
696747010093	dimerization interface [polypeptide binding]; other site
696747010094	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747010095	DNA binding site [nucleotide binding]
696747010096	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
696747010097	GAF domain; Region: GAF_2; pfam13185
696747010098	Protein of unknown function (DUF456); Region: DUF456; pfam04306
696747010099	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
696747010100	putative active site pocket [active]
696747010101	dimerization interface [polypeptide binding]; other site
696747010102	putative catalytic residue [active]
696747010103	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
696747010104	MgtE intracellular N domain; Region: MgtE_N; smart00924
696747010105	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
696747010106	Divalent cation transporter; Region: MgtE; pfam01769
696747010107	GTPase CgtA; Reviewed; Region: obgE; PRK12299
696747010108	GTP1/OBG; Region: GTP1_OBG; pfam01018
696747010109	Obg GTPase; Region: Obg; cd01898
696747010110	G1 box; other site
696747010111	GTP/Mg2+ binding site [chemical binding]; other site
696747010112	Switch I region; other site
696747010113	G2 box; other site
696747010114	G3 box; other site
696747010115	Switch II region; other site
696747010116	G4 box; other site
696747010117	G5 box; other site
696747010118	Repair protein; Region: Repair_PSII; pfam04536
696747010119	AAA ATPase domain; Region: AAA_16; pfam13191
696747010120	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
696747010121	active site
696747010122	dinuclear metal binding site [ion binding]; other site
696747010123	dimerization interface [polypeptide binding]; other site
696747010124	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
696747010125	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696747010126	Coenzyme A binding pocket [chemical binding]; other site
696747010127	ribose-phosphate pyrophosphokinase; Region: PLN02369
696747010128	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
696747010129	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696747010130	active site
696747010131	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747010132	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747010133	active site
696747010134	ATP binding site [chemical binding]; other site
696747010135	substrate binding site [chemical binding]; other site
696747010136	activation loop (A-loop); other site
696747010137	AAA domain; Region: AAA_26; pfam13500
696747010138	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
696747010139	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
696747010140	Amidinotransferase; Region: Amidinotransf; cl12043
696747010141	Uncharacterized conserved protein [Function unknown]; Region: COG1915
696747010142	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
696747010143	homodimer interface [polypeptide binding]; other site
696747010144	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
696747010145	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747010146	cofactor binding site; other site
696747010147	DNA binding site [nucleotide binding]
696747010148	substrate interaction site [chemical binding]; other site
696747010149	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747010150	Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549
696747010151	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
696747010152	WD40 repeats; Region: WD40; smart00320
696747010153	WD40 repeats; Region: WD40; smart00320
696747010154	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747010155	structural tetrad; other site
696747010156	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747010157	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747010158	structural tetrad; other site
696747010159	AAA ATPase domain; Region: AAA_16; pfam13191
696747010160	AAA domain; Region: AAA_22; pfam13401
696747010161	arginine decarboxylase; Provisional; Region: PRK05354
696747010162	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
696747010163	dimer interface [polypeptide binding]; other site
696747010164	active site
696747010165	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
696747010166	catalytic residues [active]
696747010167	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
696747010168	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
696747010169	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
696747010170	active site
696747010171	4-alpha-glucanotransferase; Provisional; Region: PRK14508
696747010172	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
696747010173	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
696747010174	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
696747010175	putative active site [active]
696747010176	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
696747010177	putative active site [active]
696747010178	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
696747010179	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
696747010180	Double zinc ribbon; Region: DZR; pfam12773
696747010181	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
696747010182	Protein kinase domain; Region: Pkinase; pfam00069
696747010183	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747010184	active site
696747010185	ATP binding site [chemical binding]; other site
696747010186	substrate binding site [chemical binding]; other site
696747010187	activation loop (A-loop); other site
696747010188	GUN4-like; Region: GUN4; pfam05419
696747010189	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
696747010190	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
696747010191	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
696747010192	CHASE2 domain; Region: CHASE2; pfam05226
696747010193	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747010194	cyclase homology domain; Region: CHD; cd07302
696747010195	nucleotidyl binding site; other site
696747010196	metal binding site [ion binding]; metal-binding site
696747010197	dimer interface [polypeptide binding]; other site
696747010198	Response regulator receiver domain; Region: Response_reg; pfam00072
696747010199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747010200	active site
696747010201	phosphorylation site [posttranslational modification]
696747010202	intermolecular recognition site; other site
696747010203	dimerization interface [polypeptide binding]; other site
696747010204	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
696747010205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747010206	active site
696747010207	phosphorylation site [posttranslational modification]
696747010208	intermolecular recognition site; other site
696747010209	dimerization interface [polypeptide binding]; other site
696747010210	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696747010211	DNA binding residues [nucleotide binding]
696747010212	dimerization interface [polypeptide binding]; other site
696747010213	Response regulator receiver domain; Region: Response_reg; pfam00072
696747010214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747010215	active site
696747010216	phosphorylation site [posttranslational modification]
696747010217	intermolecular recognition site; other site
696747010218	dimerization interface [polypeptide binding]; other site
696747010219	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747010220	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747010221	dimer interface [polypeptide binding]; other site
696747010222	phosphorylation site [posttranslational modification]
696747010223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747010224	ATP binding site [chemical binding]; other site
696747010225	Mg2+ binding site [ion binding]; other site
696747010226	G-X-G motif; other site
696747010227	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
696747010228	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
696747010229	dimer interface [polypeptide binding]; other site
696747010230	anticodon binding site; other site
696747010231	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
696747010232	homodimer interface [polypeptide binding]; other site
696747010233	motif 1; other site
696747010234	active site
696747010235	motif 2; other site
696747010236	GAD domain; Region: GAD; pfam02938
696747010237	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
696747010238	motif 3; other site
696747010239	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
696747010240	putative DNA binding helix; other site
696747010241	metal binding site 2 [ion binding]; metal-binding site
696747010242	metal binding site 1 [ion binding]; metal-binding site
696747010243	dimer interface [polypeptide binding]; other site
696747010244	structural Zn2+ binding site [ion binding]; other site
696747010245	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
696747010246	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
696747010247	oligomeric interface; other site
696747010248	putative active site [active]
696747010249	homodimer interface [polypeptide binding]; other site
696747010250	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
696747010251	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
696747010252	Protein of unknown function (DUF1229); Region: DUF1229; pfam06797
696747010253	DNA-sulfur modification-associated; Region: DndB; cl17621
696747010254	Protein of unknown function DUF86; Region: DUF86; cl01031
696747010255	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
696747010256	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
696747010257	Methyltransferase domain; Region: Methyltransf_26; pfam13659
696747010258	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010259	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010260	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747010261	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747010262	putative active site [active]
696747010263	putative NTP binding site [chemical binding]; other site
696747010264	putative nucleic acid binding site [nucleotide binding]; other site
696747010265	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747010266	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747010267	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747010268	active site
696747010269	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
696747010270	DNA binding residues [nucleotide binding]
696747010271	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
696747010272	ADP-ribose binding site [chemical binding]; other site
696747010273	Uncharacterized conserved protein [Function unknown]; Region: COG3465
696747010274	Uncharacterized conserved protein [Function unknown]; Region: COG2442
696747010275	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
696747010276	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
696747010277	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696747010278	catalytic residue [active]
696747010279	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
696747010280	Ligand Binding Site [chemical binding]; other site
696747010281	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
696747010282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
696747010283	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
696747010284	FtsH Extracellular; Region: FtsH_ext; pfam06480
696747010285	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
696747010286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747010287	Walker A motif; other site
696747010288	ATP binding site [chemical binding]; other site
696747010289	Walker B motif; other site
696747010290	arginine finger; other site
696747010291	Peptidase family M41; Region: Peptidase_M41; pfam01434
696747010292	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747010293	TPR motif; other site
696747010294	TPR repeat; Region: TPR_11; pfam13414
696747010295	Methyltransferase domain; Region: Methyltransf_24; pfam13578
696747010296	Polysaccharide biosynthesis; Region: Polysacc_synt_4; cl04661
696747010297	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747010298	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696747010299	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747010300	TPR motif; other site
696747010301	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696747010302	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747010303	S-adenosylmethionine binding site [chemical binding]; other site
696747010304	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696747010305	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696747010306	active site
696747010307	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747010308	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696747010309	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
696747010310	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
696747010311	active site
696747010312	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
696747010313	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
696747010314	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
696747010315	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
696747010316	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747010317	cofactor binding site; other site
696747010318	DNA binding site [nucleotide binding]
696747010319	substrate interaction site [chemical binding]; other site
696747010320	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
696747010321	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
696747010322	active site
696747010323	homodimer interface [polypeptide binding]; other site
696747010324	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747010325	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747010326	putative active site [active]
696747010327	heme pocket [chemical binding]; other site
696747010328	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
696747010329	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747010330	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
696747010331	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747010332	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747010333	putative active site [active]
696747010334	heme pocket [chemical binding]; other site
696747010335	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747010336	putative active site [active]
696747010337	heme pocket [chemical binding]; other site
696747010338	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747010339	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747010340	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747010341	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747010342	metal binding site [ion binding]; metal-binding site
696747010343	active site
696747010344	I-site; other site
696747010345	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
696747010346	pseudouridine synthase; Region: TIGR00093
696747010347	active site
696747010348	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
696747010349	XdhC Rossmann domain; Region: XdhC_C; pfam13478
696747010350	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
696747010351	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
696747010352	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
696747010353	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
696747010354	Hexamer interface [polypeptide binding]; other site
696747010355	Hexagonal pore residue; other site
696747010356	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
696747010357	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
696747010358	Hexamer interface [polypeptide binding]; other site
696747010359	Hexagonal pore residue; other site
696747010360	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
696747010361	putative trimer interface [polypeptide binding]; other site
696747010362	putative CoA binding site [chemical binding]; other site
696747010363	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
696747010364	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
696747010365	trimer interface [polypeptide binding]; other site
696747010366	active site
696747010367	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
696747010368	putative multimerization interface [polypeptide binding]; other site
696747010369	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
696747010370	putative multimerization interface [polypeptide binding]; other site
696747010371	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
696747010372	putative multimerization interface [polypeptide binding]; other site
696747010373	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
696747010374	Hexamer/Pentamer interface [polypeptide binding]; other site
696747010375	central pore; other site
696747010376	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
696747010377	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
696747010378	Hexamer interface [polypeptide binding]; other site
696747010379	Hexagonal pore residue; other site
696747010380	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
696747010381	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
696747010382	Hexamer interface [polypeptide binding]; other site
696747010383	Hexagonal pore residue; other site
696747010384	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
696747010385	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696747010386	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
696747010387	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696747010388	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
696747010389	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
696747010390	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696747010391	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747010392	Walker A/P-loop; other site
696747010393	ATP binding site [chemical binding]; other site
696747010394	Q-loop/lid; other site
696747010395	ABC transporter signature motif; other site
696747010396	Walker B; other site
696747010397	D-loop; other site
696747010398	H-loop/switch region; other site
696747010399	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
696747010400	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
696747010401	NADPH bind site [chemical binding]; other site
696747010402	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
696747010403	putative FMN binding site [chemical binding]; other site
696747010404	NADPH bind site [chemical binding]; other site
696747010405	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
696747010406	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
696747010407	active site
696747010408	substrate binding site [chemical binding]; other site
696747010409	catalytic site [active]
696747010410	AAA ATPase domain; Region: AAA_16; pfam13191
696747010411	AAA domain; Region: AAA_22; pfam13401
696747010412	Walker A motif; other site
696747010413	ATP binding site [chemical binding]; other site
696747010414	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
696747010415	DNA adenine methylase (dam); Region: dam; TIGR00571
696747010416	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010417	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747010418	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747010419	putative active site [active]
696747010420	putative NTP binding site [chemical binding]; other site
696747010421	putative nucleic acid binding site [nucleotide binding]; other site
696747010422	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747010423	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747010424	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747010425	active site
696747010426	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
696747010427	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
696747010428	Walker A/P-loop; other site
696747010429	ATP binding site [chemical binding]; other site
696747010430	Q-loop/lid; other site
696747010431	ABC transporter signature motif; other site
696747010432	Walker B; other site
696747010433	D-loop; other site
696747010434	H-loop/switch region; other site
696747010435	TOBE domain; Region: TOBE_2; pfam08402
696747010436	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
696747010437	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
696747010438	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
696747010439	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747010440	dimer interface [polypeptide binding]; other site
696747010441	conserved gate region; other site
696747010442	putative PBP binding loops; other site
696747010443	ABC-ATPase subunit interface; other site
696747010444	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
696747010445	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747010446	dimer interface [polypeptide binding]; other site
696747010447	conserved gate region; other site
696747010448	putative PBP binding loops; other site
696747010449	ABC-ATPase subunit interface; other site
696747010450	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
696747010451	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
696747010452	active site
696747010453	Riboflavin kinase; Region: Flavokinase; pfam01687
696747010454	MoxR-like ATPases [General function prediction only]; Region: COG0714
696747010455	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747010456	ATP binding site [chemical binding]; other site
696747010457	Walker A motif; other site
696747010458	Walker B motif; other site
696747010459	arginine finger; other site
696747010460	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
696747010461	Rrf2 family protein; Region: rrf2_super; TIGR00738
696747010462	Transcriptional regulator; Region: Rrf2; cl17282
696747010463	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
696747010464	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
696747010465	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696747010466	active site
696747010467	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
696747010468	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
696747010469	homotetramer interface [polypeptide binding]; other site
696747010470	FMN binding site [chemical binding]; other site
696747010471	homodimer contacts [polypeptide binding]; other site
696747010472	putative active site [active]
696747010473	putative substrate binding site [chemical binding]; other site
696747010474	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
696747010475	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
696747010476	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
696747010477	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
696747010478	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
696747010479	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
696747010480	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
696747010481	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
696747010482	active site
696747010483	interdomain interaction site; other site
696747010484	putative metal-binding site [ion binding]; other site
696747010485	nucleotide binding site [chemical binding]; other site
696747010486	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
696747010487	domain I; other site
696747010488	phosphate binding site [ion binding]; other site
696747010489	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
696747010490	domain II; other site
696747010491	domain III; other site
696747010492	nucleotide binding site [chemical binding]; other site
696747010493	DNA binding groove [nucleotide binding]
696747010494	catalytic site [active]
696747010495	domain IV; other site
696747010496	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
696747010497	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
696747010498	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
696747010499	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
696747010500	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
696747010501	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
696747010502	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
696747010503	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
696747010504	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
696747010505	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747010506	Walker A/P-loop; other site
696747010507	ATP binding site [chemical binding]; other site
696747010508	Q-loop/lid; other site
696747010509	ABC transporter signature motif; other site
696747010510	Walker B; other site
696747010511	D-loop; other site
696747010512	H-loop/switch region; other site
696747010513	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
696747010514	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
696747010515	substrate binding pocket [chemical binding]; other site
696747010516	membrane-bound complex binding site; other site
696747010517	hinge residues; other site
696747010518	PAS fold; Region: PAS_3; pfam08447
696747010519	PAS domain S-box; Region: sensory_box; TIGR00229
696747010520	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747010521	putative active site [active]
696747010522	heme pocket [chemical binding]; other site
696747010523	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747010524	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747010525	metal binding site [ion binding]; metal-binding site
696747010526	active site
696747010527	I-site; other site
696747010528	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747010529	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
696747010530	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
696747010531	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
696747010532	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
696747010533	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747010534	Mg2+ binding site [ion binding]; other site
696747010535	G-X-G motif; other site
696747010536	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
696747010537	anchoring element; other site
696747010538	dimer interface [polypeptide binding]; other site
696747010539	ATP binding site [chemical binding]; other site
696747010540	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
696747010541	active site
696747010542	putative metal-binding site [ion binding]; other site
696747010543	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
696747010544	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
696747010545	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
696747010546	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747010547	Walker A motif; other site
696747010548	ATP binding site [chemical binding]; other site
696747010549	Walker B motif; other site
696747010550	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
696747010551	Clp protease; Region: CLP_protease; pfam00574
696747010552	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
696747010553	oligomer interface [polypeptide binding]; other site
696747010554	active site residues [active]
696747010555	trigger factor; Provisional; Region: tig; PRK01490
696747010556	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
696747010557	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
696747010558	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
696747010559	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
696747010560	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
696747010561	dihydrodipicolinate synthase; Region: dapA; TIGR00674
696747010562	dimer interface [polypeptide binding]; other site
696747010563	active site
696747010564	catalytic residue [active]
696747010565	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
696747010566	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
696747010567	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
696747010568	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696747010569	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747010570	ligand binding site [chemical binding]; other site
696747010571	flexible hinge region; other site
696747010572	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
696747010573	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747010574	Walker A motif; other site
696747010575	ATP binding site [chemical binding]; other site
696747010576	Walker B motif; other site
696747010577	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
696747010578	4Fe-4S binding domain; Region: Fer4_5; pfam12801
696747010579	4Fe-4S binding domain; Region: Fer4_5; pfam12801
696747010580	Uncharacterized conserved protein [Function unknown]; Region: COG1479
696747010581	Protein of unknown function DUF262; Region: DUF262; pfam03235
696747010582	O-succinylbenzoate synthase; Provisional; Region: PRK02714
696747010583	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
696747010584	active site
696747010585	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
696747010586	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
696747010587	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
696747010588	P-loop; other site
696747010589	Magnesium ion binding site [ion binding]; other site
696747010590	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
696747010591	Magnesium ion binding site [ion binding]; other site
696747010592	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
696747010593	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747010594	PAS domain; Region: PAS_9; pfam13426
696747010595	putative active site [active]
696747010596	heme pocket [chemical binding]; other site
696747010597	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747010598	PAS domain; Region: PAS_9; pfam13426
696747010599	putative active site [active]
696747010600	heme pocket [chemical binding]; other site
696747010601	PAS fold; Region: PAS_4; pfam08448
696747010602	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747010603	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747010604	dimer interface [polypeptide binding]; other site
696747010605	phosphorylation site [posttranslational modification]
696747010606	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747010607	ATP binding site [chemical binding]; other site
696747010608	Mg2+ binding site [ion binding]; other site
696747010609	G-X-G motif; other site
696747010610	PAS domain; Region: PAS_9; pfam13426
696747010611	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747010612	putative active site [active]
696747010613	heme pocket [chemical binding]; other site
696747010614	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747010615	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747010616	metal binding site [ion binding]; metal-binding site
696747010617	active site
696747010618	I-site; other site
696747010619	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747010620	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
696747010621	MgtE intracellular N domain; Region: MgtE_N; smart00924
696747010622	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
696747010623	Divalent cation transporter; Region: MgtE; pfam01769
696747010624	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
696747010625	putative binding surface; other site
696747010626	active site
696747010627	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747010628	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747010629	putative active site [active]
696747010630	putative nucleic acid binding site [nucleotide binding]; other site
696747010631	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747010632	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747010633	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747010634	active site
696747010635	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747010636	putative NTP binding site [chemical binding]; other site
696747010637	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010638	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747010639	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010640	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010641	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747010642	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010643	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010644	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010645	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010646	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010647	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747010648	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747010649	putative active site [active]
696747010650	putative NTP binding site [chemical binding]; other site
696747010651	putative nucleic acid binding site [nucleotide binding]; other site
696747010652	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747010653	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747010654	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747010655	active site
696747010656	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
696747010657	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747010658	Calx-beta domain; Region: Calx-beta; cl02522
696747010659	Calx-beta domain; Region: Calx-beta; cl02522
696747010660	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
696747010661	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
696747010662	RNase E interface [polypeptide binding]; other site
696747010663	trimer interface [polypeptide binding]; other site
696747010664	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
696747010665	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
696747010666	RNase E interface [polypeptide binding]; other site
696747010667	trimer interface [polypeptide binding]; other site
696747010668	active site
696747010669	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
696747010670	putative nucleic acid binding region [nucleotide binding]; other site
696747010671	G-X-X-G motif; other site
696747010672	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
696747010673	RNA binding site [nucleotide binding]; other site
696747010674	domain interface; other site
696747010675	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
696747010676	SNF2 Helicase protein; Region: DUF3670; pfam12419
696747010677	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747010678	ATP binding site [chemical binding]; other site
696747010679	putative Mg++ binding site [ion binding]; other site
696747010680	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747010681	nucleotide binding region [chemical binding]; other site
696747010682	ATP-binding site [chemical binding]; other site
696747010683	putative acyltransferase; Provisional; Region: PRK05790
696747010684	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
696747010685	dimer interface [polypeptide binding]; other site
696747010686	active site
696747010687	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
696747010688	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747010689	NAD(P) binding site [chemical binding]; other site
696747010690	active site
696747010691	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010692	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747010693	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747010694	putative active site [active]
696747010695	putative NTP binding site [chemical binding]; other site
696747010696	putative nucleic acid binding site [nucleotide binding]; other site
696747010697	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747010698	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747010699	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747010700	active site
696747010701	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747010702	Probable transposase; Region: OrfB_IS605; pfam01385
696747010703	FOG: WD40-like repeat [Function unknown]; Region: COG1520
696747010704	Phycobilisome protein; Region: Phycobilisome; cl08227
696747010705	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
696747010706	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
696747010707	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747010708	S-adenosylmethionine binding site [chemical binding]; other site
696747010709	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
696747010710	FeoA domain; Region: FeoA; pfam04023
696747010711	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
696747010712	Nucleoside recognition; Region: Gate; pfam07670
696747010713	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
696747010714	Nucleoside recognition; Region: Gate; pfam07670
696747010715	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
696747010716	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
696747010717	G1 box; other site
696747010718	GTP/Mg2+ binding site [chemical binding]; other site
696747010719	Switch I region; other site
696747010720	G2 box; other site
696747010721	G3 box; other site
696747010722	Switch II region; other site
696747010723	G4 box; other site
696747010724	G5 box; other site
696747010725	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
696747010726	oxyanion hole [active]
696747010727	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
696747010728	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
696747010729	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747010730	ATP binding site [chemical binding]; other site
696747010731	putative Mg++ binding site [ion binding]; other site
696747010732	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747010733	nucleotide binding region [chemical binding]; other site
696747010734	ATP-binding site [chemical binding]; other site
696747010735	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
696747010736	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
696747010737	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
696747010738	Walker A/P-loop; other site
696747010739	ATP binding site [chemical binding]; other site
696747010740	Q-loop/lid; other site
696747010741	ABC transporter signature motif; other site
696747010742	Walker B; other site
696747010743	D-loop; other site
696747010744	H-loop/switch region; other site
696747010745	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
696747010746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747010747	S-adenosylmethionine binding site [chemical binding]; other site
696747010748	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747010749	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747010750	active site
696747010751	ATP binding site [chemical binding]; other site
696747010752	substrate binding site [chemical binding]; other site
696747010753	activation loop (A-loop); other site
696747010754	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
696747010755	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
696747010756	putative NAD(P) binding site [chemical binding]; other site
696747010757	putative substrate binding site [chemical binding]; other site
696747010758	catalytic Zn binding site [ion binding]; other site
696747010759	structural Zn binding site [ion binding]; other site
696747010760	dimer interface [polypeptide binding]; other site
696747010761	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
696747010762	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
696747010763	putative catalytic cysteine [active]
696747010764	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
696747010765	putative active site [active]
696747010766	metal binding site [ion binding]; metal-binding site
696747010767	AAA ATPase domain; Region: AAA_16; pfam13191
696747010768	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
696747010769	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
696747010770	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
696747010771	glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377
696747010772	glutathione reductase; Validated; Region: PRK06116
696747010773	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696747010774	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696747010775	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
696747010776	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
696747010777	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
696747010778	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010779	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747010780	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010781	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747010782	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010783	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010784	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
696747010785	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696747010786	Zn2+ binding site [ion binding]; other site
696747010787	Mg2+ binding site [ion binding]; other site
696747010788	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
696747010789	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
696747010790	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696747010791	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
696747010792	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696747010793	motif II; other site
696747010794	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
696747010795	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
696747010796	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
696747010797	active site residue [active]
696747010798	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
696747010799	active site residue [active]
696747010800	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747010801	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747010802	Membrane protein of unknown function; Region: DUF360; pfam04020
696747010803	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
696747010804	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
696747010805	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
696747010806	substrate binding pocket [chemical binding]; other site
696747010807	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
696747010808	B12 binding site [chemical binding]; other site
696747010809	cobalt ligand [ion binding]; other site
696747010810	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
696747010811	spermidine synthase; Provisional; Region: PRK00811
696747010812	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747010813	S-adenosylmethionine binding site [chemical binding]; other site
696747010814	gamma-glutamyl kinase; Provisional; Region: PRK05429
696747010815	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
696747010816	nucleotide binding site [chemical binding]; other site
696747010817	homotetrameric interface [polypeptide binding]; other site
696747010818	putative phosphate binding site [ion binding]; other site
696747010819	putative allosteric binding site; other site
696747010820	PUA domain; Region: PUA; pfam01472
696747010821	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
696747010822	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696747010823	YceG-like family; Region: YceG; pfam02618
696747010824	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
696747010825	dimerization interface [polypeptide binding]; other site
696747010826	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
696747010827	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
696747010828	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
696747010829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696747010830	Coenzyme A binding pocket [chemical binding]; other site
696747010831	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
696747010832	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747010833	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747010834	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747010835	active site
696747010836	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010837	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747010838	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747010839	putative active site [active]
696747010840	putative NTP binding site [chemical binding]; other site
696747010841	putative nucleic acid binding site [nucleotide binding]; other site
696747010842	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010843	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
696747010844	ribosomal protein L21; Region: rpl21; CHL00075
696747010845	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747010846	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
696747010847	Winged helix-turn helix; Region: HTH_33; pfam13592
696747010848	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747010849	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747010850	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747010851	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
696747010852	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696747010853	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
696747010854	Walker A motif; other site
696747010855	Walker A motif; other site
696747010856	ATP binding site [chemical binding]; other site
696747010857	Walker B motif; other site
696747010858	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696747010859	ATP binding site [chemical binding]; other site
696747010860	Walker B motif; other site
696747010861	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
696747010862	tetramer interface [polypeptide binding]; other site
696747010863	dimer interface [polypeptide binding]; other site
696747010864	KaiA domain; Region: KaiA; pfam07688
696747010865	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747010866	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747010867	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747010868	metal binding site [ion binding]; metal-binding site
696747010869	active site
696747010870	I-site; other site
696747010871	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
696747010872	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
696747010873	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
696747010874	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
696747010875	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
696747010876	active site
696747010877	metal binding site [ion binding]; metal-binding site
696747010878	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
696747010879	Domain of unknown function (DUF814); Region: DUF814; pfam05670
696747010880	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
696747010881	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
696747010882	FMN binding site [chemical binding]; other site
696747010883	active site
696747010884	substrate binding site [chemical binding]; other site
696747010885	catalytic residue [active]
696747010886	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747010887	putative active site [active]
696747010888	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747010889	putative active site [active]
696747010890	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747010891	putative active site [active]
696747010892	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
696747010893	Low molecular weight phosphatase family; Region: LMWPc; cl00105
696747010894	active site
696747010895	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
696747010896	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
696747010897	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
696747010898	arsenical-resistance protein; Region: acr3; TIGR00832
696747010899	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747010900	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747010901	Winged helix-turn helix; Region: HTH_29; pfam13551
696747010902	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
696747010903	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
696747010904	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
696747010905	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747010906	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747010907	active site
696747010908	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747010909	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747010910	putative active site [active]
696747010911	putative nucleic acid binding site [nucleotide binding]; other site
696747010912	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747010913	putative NTP binding site [chemical binding]; other site
696747010914	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010915	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010916	Winged helix-turn helix; Region: HTH_29; pfam13551
696747010917	Homeodomain-like domain; Region: HTH_23; cl17451
696747010918	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747010919	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747010920	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
696747010921	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
696747010922	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
696747010923	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696747010924	non-specific DNA binding site [nucleotide binding]; other site
696747010925	salt bridge; other site
696747010926	sequence-specific DNA binding site [nucleotide binding]; other site
696747010927	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
696747010928	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747010929	cofactor binding site; other site
696747010930	DNA binding site [nucleotide binding]
696747010931	substrate interaction site [chemical binding]; other site
696747010932	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
696747010933	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
696747010934	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
696747010935	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
696747010936	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
696747010937	ATP-grasp domain; Region: ATP-grasp_4; cl17255
696747010938	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
696747010939	IMP binding site; other site
696747010940	dimer interface [polypeptide binding]; other site
696747010941	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
696747010942	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
696747010943	nucleotide binding site [chemical binding]; other site
696747010944	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
696747010945	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
696747010946	Probable transposase; Region: OrfB_IS605; pfam01385
696747010947	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747010948	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747010949	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747010950	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747010951	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747010952	active site
696747010953	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747010954	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747010955	putative active site [active]
696747010956	putative nucleic acid binding site [nucleotide binding]; other site
696747010957	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747010958	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010959	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010960	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
696747010961	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
696747010962	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
696747010963	cytochrome b subunit interaction site [polypeptide binding]; other site
696747010964	[2Fe-2S] cluster binding site [ion binding]; other site
696747010965	apocytochrome f; Reviewed; Region: PRK02693
696747010966	cytochrome f; Region: petA; CHL00037
696747010967	alpha/beta hydrolase fold protein; Provisional; Region: PLN03084
696747010968	Winged helix-turn helix; Region: HTH_33; pfam13592
696747010969	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747010970	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010971	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747010972	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747010973	putative active site [active]
696747010974	putative NTP binding site [chemical binding]; other site
696747010975	putative nucleic acid binding site [nucleotide binding]; other site
696747010976	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747010977	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747010978	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747010979	active site
696747010980	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747010981	Winged helix-turn helix; Region: HTH_33; pfam13592
696747010982	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747010983	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747010984	Winged helix-turn helix; Region: HTH_33; pfam13592
696747010985	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747010986	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747010987	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
696747010988	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
696747010989	putative catalytic cysteine [active]
696747010990	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
696747010991	Fatty acid desaturase; Region: FA_desaturase; pfam00487
696747010992	Di-iron ligands [ion binding]; other site
696747010993	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
696747010994	Aluminium resistance protein; Region: Alum_res; pfam06838
696747010995	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747010996	Probable transposase; Region: OrfB_IS605; pfam01385
696747010997	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
696747010998	Response regulator receiver domain; Region: Response_reg; pfam00072
696747010999	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747011000	active site
696747011001	phosphorylation site [posttranslational modification]
696747011002	intermolecular recognition site; other site
696747011003	dimerization interface [polypeptide binding]; other site
696747011004	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747011005	ATP binding site [chemical binding]; other site
696747011006	Mg2+ binding site [ion binding]; other site
696747011007	G-X-G motif; other site
696747011008	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696747011009	dimerization interface [polypeptide binding]; other site
696747011010	putative DNA binding site [nucleotide binding]; other site
696747011011	putative Zn2+ binding site [ion binding]; other site
696747011012	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
696747011013	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
696747011014	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
696747011015	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
696747011016	P loop; other site
696747011017	Nucleotide binding site [chemical binding]; other site
696747011018	DTAP/Switch II; other site
696747011019	Switch I; other site
696747011020	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
696747011021	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
696747011022	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747011023	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747011024	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
696747011025	active site
696747011026	catalytic residues [active]
696747011027	DNA binding site [nucleotide binding]
696747011028	Int/Topo IB signature motif; other site
696747011029	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696747011030	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696747011031	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
696747011032	RNA binding site [nucleotide binding]; other site
696747011033	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
696747011034	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
696747011035	Putative restriction endonuclease; Region: Uma2; pfam05685
696747011036	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
696747011037	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
696747011038	catalytic triad [active]
696747011039	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
696747011040	active site
696747011041	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
696747011042	Part of AAA domain; Region: AAA_19; pfam13245
696747011043	Family description; Region: UvrD_C_2; pfam13538
696747011044	Elongation factor 1 gamma, conserved domain; Region: EF1G; pfam00647
696747011045	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
696747011046	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
696747011047	N-acetyl-D-glucosamine binding site [chemical binding]; other site
696747011048	catalytic residue [active]
696747011049	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
696747011050	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696747011051	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747011052	S-adenosylmethionine binding site [chemical binding]; other site
696747011053	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
696747011054	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
696747011055	intersubunit interface [polypeptide binding]; other site
696747011056	active site
696747011057	zinc binding site [ion binding]; other site
696747011058	Na+ binding site [ion binding]; other site
696747011059	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
696747011060	active site
696747011061	catalytic residues [active]
696747011062	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
696747011063	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
696747011064	putative active site [active]
696747011065	putative metal binding site [ion binding]; other site
696747011066	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
696747011067	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696747011068	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
696747011069	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
696747011070	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
696747011071	YCII-related domain; Region: YCII; cl00999
696747011072	Uncharacterized conserved protein [Function unknown]; Region: COG3937
696747011073	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
696747011074	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747011075	ATP binding site [chemical binding]; other site
696747011076	putative Mg++ binding site [ion binding]; other site
696747011077	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747011078	nucleotide binding region [chemical binding]; other site
696747011079	ATP-binding site [chemical binding]; other site
696747011080	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
696747011081	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747011082	Walker A/P-loop; other site
696747011083	ATP binding site [chemical binding]; other site
696747011084	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
696747011085	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
696747011086	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
696747011087	catalytic residues [active]
696747011088	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
696747011089	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
696747011090	Predicted membrane protein [Function unknown]; Region: COG3463
696747011091	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
696747011092	Predicted membrane protein [Function unknown]; Region: COG3463
696747011093	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
696747011094	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696747011095	putative substrate translocation pore; other site
696747011096	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
696747011097	PAS fold; Region: PAS_3; pfam08447
696747011098	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747011099	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747011100	putative active site [active]
696747011101	heme pocket [chemical binding]; other site
696747011102	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747011103	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747011104	putative active site [active]
696747011105	heme pocket [chemical binding]; other site
696747011106	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747011107	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747011108	putative active site [active]
696747011109	heme pocket [chemical binding]; other site
696747011110	PAS domain; Region: PAS; smart00091
696747011111	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747011112	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747011113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747011114	dimer interface [polypeptide binding]; other site
696747011115	phosphorylation site [posttranslational modification]
696747011116	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747011117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747011118	ATP binding site [chemical binding]; other site
696747011119	Mg2+ binding site [ion binding]; other site
696747011120	G-X-G motif; other site
696747011121	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
696747011122	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
696747011123	dimerization interface [polypeptide binding]; other site
696747011124	putative DNA binding site [nucleotide binding]; other site
696747011125	putative Zn2+ binding site [ion binding]; other site
696747011126	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
696747011127	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
696747011128	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
696747011129	dimerization interface [polypeptide binding]; other site
696747011130	FAD binding pocket [chemical binding]; other site
696747011131	FAD binding motif [chemical binding]; other site
696747011132	catalytic residues [active]
696747011133	NAD binding pocket [chemical binding]; other site
696747011134	phosphate binding motif [ion binding]; other site
696747011135	beta-alpha-beta structure motif; other site
696747011136	cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665
696747011137	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747011138	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747011139	active site
696747011140	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747011141	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747011142	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747011143	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747011144	active site
696747011145	ATP binding site [chemical binding]; other site
696747011146	substrate binding site [chemical binding]; other site
696747011147	activation loop (A-loop); other site
696747011148	Uncharacterized conserved protein [Function unknown]; Region: COG1262
696747011149	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
696747011150	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747011151	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747011152	active site
696747011153	ATP binding site [chemical binding]; other site
696747011154	substrate binding site [chemical binding]; other site
696747011155	activation loop (A-loop); other site
696747011156	Uncharacterized conserved protein [Function unknown]; Region: COG1262
696747011157	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
696747011158	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747011159	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747011160	active site
696747011161	ATP binding site [chemical binding]; other site
696747011162	substrate binding site [chemical binding]; other site
696747011163	activation loop (A-loop); other site
696747011164	Uncharacterized conserved protein [Function unknown]; Region: COG1262
696747011165	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
696747011166	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747011167	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747011168	active site
696747011169	ATP binding site [chemical binding]; other site
696747011170	substrate binding site [chemical binding]; other site
696747011171	activation loop (A-loop); other site
696747011172	Uncharacterized conserved protein [Function unknown]; Region: COG1262
696747011173	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
696747011174	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
696747011175	DNA photolyase; Region: DNA_photolyase; pfam00875
696747011176	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
696747011177	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
696747011178	dimer interface [polypeptide binding]; other site
696747011179	ADP-ribose binding site [chemical binding]; other site
696747011180	active site
696747011181	nudix motif; other site
696747011182	metal binding site [ion binding]; metal-binding site
696747011183	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
696747011184	catalytic center binding site [active]
696747011185	ATP binding site [chemical binding]; other site
696747011186	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747011187	binding surface
696747011188	TPR motif; other site
696747011189	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747011190	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747011191	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747011192	binding surface
696747011193	TPR motif; other site
696747011194	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747011195	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747011196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747011197	binding surface
696747011198	TPR motif; other site
696747011199	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747011200	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747011201	FO synthase subunit 2; Reviewed; Region: PRK07360
696747011202	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747011203	FeS/SAM binding site; other site
696747011204	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747011205	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747011206	phosphopeptide binding site; other site
696747011207	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
696747011208	Transglycosylase; Region: Transgly; pfam00912
696747011209	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
696747011210	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
696747011211	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
696747011212	P-loop; other site
696747011213	Magnesium ion binding site [ion binding]; other site
696747011214	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
696747011215	Magnesium ion binding site [ion binding]; other site
696747011216	Bacterial Ig-like domain; Region: Big_5; pfam13205
696747011217	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
696747011218	MG2 domain; Region: A2M_N; pfam01835
696747011219	Alpha-2-macroglobulin family; Region: A2M; pfam00207
696747011220	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
696747011221	glucokinase; Provisional; Region: glk; PRK00292
696747011222	glucokinase, proteobacterial type; Region: glk; TIGR00749
696747011223	putative phosphoketolase; Provisional; Region: PRK05261
696747011224	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
696747011225	TPP-binding site; other site
696747011226	XFP C-terminal domain; Region: XFP_C; pfam09363
696747011227	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
696747011228	propionate/acetate kinase; Provisional; Region: PRK12379
696747011229	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
696747011230	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
696747011231	tetramer interface [polypeptide binding]; other site
696747011232	TPP-binding site [chemical binding]; other site
696747011233	heterodimer interface [polypeptide binding]; other site
696747011234	phosphorylation loop region [posttranslational modification]
696747011235	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
696747011236	HSP70 interaction site [polypeptide binding]; other site
696747011237	Transcription factor PAP1; Region: PAP1; pfam08601
696747011238	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
696747011239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747011240	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747011241	Probable transposase; Region: OrfB_IS605; pfam01385
696747011242	Probable transposase; Region: OrfB_IS605; pfam01385
696747011243	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747011244	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747011245	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
696747011246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
696747011247	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
696747011248	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
696747011249	Ligand Binding Site [chemical binding]; other site
696747011250	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
696747011251	4Fe-4S binding domain; Region: Fer4; pfam00037
696747011252	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
696747011253	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
696747011254	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
696747011255	catalytic residues [active]
696747011256	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
696747011257	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
696747011258	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
696747011259	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
696747011260	M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343
696747011261	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
696747011262	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
696747011263	active site flap/lid [active]
696747011264	nucleophilic elbow; other site
696747011265	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747011266	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747011267	metal binding site [ion binding]; metal-binding site
696747011268	active site
696747011269	I-site; other site
696747011270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747011271	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
696747011272	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
696747011273	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747011274	active site
696747011275	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747011276	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747011277	HEAT repeats; Region: HEAT_2; pfam13646
696747011278	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
696747011279	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
696747011280	hinge; other site
696747011281	active site
696747011282	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
696747011283	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
696747011284	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747011285	FeS/SAM binding site; other site
696747011286	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
696747011287	Mechanosensitive ion channel; Region: MS_channel; pfam00924
696747011288	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
696747011289	dimer interface [polypeptide binding]; other site
696747011290	[2Fe-2S] cluster binding site [ion binding]; other site
696747011291	haemagglutination activity domain; Region: Haemagg_act; pfam05860
696747011292	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696747011293	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696747011294	MarR family; Region: MarR_2; cl17246
696747011295	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
696747011296	active site
696747011297	catalytic residues [active]
696747011298	DNA binding site [nucleotide binding]
696747011299	Int/Topo IB signature motif; other site
696747011300	Class I aldolases; Region: Aldolase_Class_I; cl17187
696747011301	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
696747011302	Putative restriction endonuclease; Region: Uma2; pfam05685
696747011303	Protein of unknown function DUF104; Region: DUF104; pfam01954
696747011304	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
696747011305	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
696747011306	Putative restriction endonuclease; Region: Uma2; pfam05685
696747011307	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696747011308	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747011309	Walker A/P-loop; other site
696747011310	ATP binding site [chemical binding]; other site
696747011311	Q-loop/lid; other site
696747011312	ABC transporter signature motif; other site
696747011313	Walker B; other site
696747011314	D-loop; other site
696747011315	H-loop/switch region; other site
696747011316	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
696747011317	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
696747011318	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
696747011319	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747011320	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747011321	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747011322	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747011323	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747011324	dimer interface [polypeptide binding]; other site
696747011325	phosphorylation site [posttranslational modification]
696747011326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747011327	ATP binding site [chemical binding]; other site
696747011328	Mg2+ binding site [ion binding]; other site
696747011329	G-X-G motif; other site
696747011330	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747011331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747011332	active site
696747011333	phosphorylation site [posttranslational modification]
696747011334	intermolecular recognition site; other site
696747011335	dimerization interface [polypeptide binding]; other site
696747011336	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
696747011337	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
696747011338	putative active site cavity [active]
696747011339	ribonuclease Z; Region: RNase_Z; TIGR02651
696747011340	phytoene desaturase; Region: crtI_fam; TIGR02734
696747011341	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696747011342	Ycf46; Provisional; Region: ycf46; CHL00195
696747011343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747011344	Walker A motif; other site
696747011345	ATP binding site [chemical binding]; other site
696747011346	Walker B motif; other site
696747011347	arginine finger; other site
696747011348	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
696747011349	glutamate-1-semialdehyde-2,1-aminomutase; Region: hemL; TIGR00713
696747011350	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
696747011351	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
696747011352	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
696747011353	substrate binding site [chemical binding]; other site
696747011354	activation loop (A-loop); other site
696747011355	Protein phosphatase 2C; Region: PP2C_2; pfam13672
696747011356	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
696747011357	metal ion-dependent adhesion site (MIDAS); other site
696747011358	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
696747011359	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
696747011360	nickel binding site [ion binding]; other site
696747011361	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
696747011362	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747011363	PAS domain; Region: PAS_9; pfam13426
696747011364	putative active site [active]
696747011365	heme pocket [chemical binding]; other site
696747011366	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
696747011367	dimer interface [polypeptide binding]; other site
696747011368	[2Fe-2S] cluster binding site [ion binding]; other site
696747011369	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
696747011370	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
696747011371	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
696747011372	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
696747011373	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
696747011374	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696747011375	catalytic loop [active]
696747011376	iron binding site [ion binding]; other site
696747011377	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
696747011378	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696747011379	hybrid cluster protein; Provisional; Region: PRK05290
696747011380	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696747011381	ACS interaction site; other site
696747011382	CODH interaction site; other site
696747011383	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696747011384	ACS interaction site; other site
696747011385	CODH interaction site; other site
696747011386	metal cluster binding site [ion binding]; other site
696747011387	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
696747011388	dimer interface [polypeptide binding]; other site
696747011389	[2Fe-2S] cluster binding site [ion binding]; other site
696747011390	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
696747011391	SLBB domain; Region: SLBB; pfam10531
696747011392	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
696747011393	bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571
696747011394	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
696747011395	putative dimer interface [polypeptide binding]; other site
696747011396	[2Fe-2S] cluster binding site [ion binding]; other site
696747011397	HupF/HypC family; Region: HupF_HypC; pfam01455
696747011398	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
696747011399	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
696747011400	dimer interface [polypeptide binding]; other site
696747011401	PYR/PP interface [polypeptide binding]; other site
696747011402	TPP binding site [chemical binding]; other site
696747011403	substrate binding site [chemical binding]; other site
696747011404	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
696747011405	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
696747011406	Domain of unknown function; Region: EKR; pfam10371
696747011407	4Fe-4S binding domain; Region: Fer4_6; pfam12837
696747011408	4Fe-4S binding domain; Region: Fer4; pfam00037
696747011409	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
696747011410	TPP-binding site [chemical binding]; other site
696747011411	dimer interface [polypeptide binding]; other site
696747011412	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
696747011413	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
696747011414	putative active site [active]
696747011415	putative FMN binding site [chemical binding]; other site
696747011416	putative substrate binding site [chemical binding]; other site
696747011417	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
696747011418	ABC1 family; Region: ABC1; cl17513
696747011419	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
696747011420	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
696747011421	inhibitor-cofactor binding pocket; inhibition site
696747011422	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747011423	catalytic residue [active]
696747011424	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
696747011425	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747011426	Winged helix-turn helix; Region: HTH_33; pfam13592
696747011427	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747011428	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747011429	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747011430	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
696747011431	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747011432	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747011433	dimerization interface [polypeptide binding]; other site
696747011434	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747011435	dimer interface [polypeptide binding]; other site
696747011436	phosphorylation site [posttranslational modification]
696747011437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747011438	ATP binding site [chemical binding]; other site
696747011439	Mg2+ binding site [ion binding]; other site
696747011440	G-X-G motif; other site
696747011441	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011442	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011443	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011444	putative NTP binding site [chemical binding]; other site
696747011445	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011446	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747011447	putative active site [active]
696747011448	putative nucleic acid binding site [nucleotide binding]; other site
696747011449	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747011450	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747011451	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747011452	active site
696747011453	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011454	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747011455	putative active site [active]
696747011456	putative nucleic acid binding site [nucleotide binding]; other site
696747011457	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747011458	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747011459	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747011460	active site
696747011461	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747011462	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747011463	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747011464	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747011465	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011466	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747011467	putative active site [active]
696747011468	putative nucleic acid binding site [nucleotide binding]; other site
696747011469	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747011470	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747011471	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747011472	active site
696747011473	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747011474	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747011475	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
696747011476	Clp amino terminal domain; Region: Clp_N; pfam02861
696747011477	Clp amino terminal domain; Region: Clp_N; pfam02861
696747011478	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747011479	Walker A motif; other site
696747011480	ATP binding site [chemical binding]; other site
696747011481	Walker B motif; other site
696747011482	arginine finger; other site
696747011483	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747011484	Walker A motif; other site
696747011485	ATP binding site [chemical binding]; other site
696747011486	Walker B motif; other site
696747011487	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
696747011488	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747011489	HAMP domain; Region: HAMP; pfam00672
696747011490	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747011491	dimer interface [polypeptide binding]; other site
696747011492	phosphorylation site [posttranslational modification]
696747011493	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747011494	ATP binding site [chemical binding]; other site
696747011495	Mg2+ binding site [ion binding]; other site
696747011496	G-X-G motif; other site
696747011497	uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792
696747011498	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
696747011499	active site
696747011500	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
696747011501	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
696747011502	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747011503	binding surface
696747011504	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011505	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747011506	putative active site [active]
696747011507	putative NTP binding site [chemical binding]; other site
696747011508	putative nucleic acid binding site [nucleotide binding]; other site
696747011509	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747011510	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
696747011511	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747011512	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747011513	active site
696747011514	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011515	Response regulator receiver domain; Region: Response_reg; pfam00072
696747011516	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747011517	active site
696747011518	phosphorylation site [posttranslational modification]
696747011519	intermolecular recognition site; other site
696747011520	dimerization interface [polypeptide binding]; other site
696747011521	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747011522	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
696747011523	G-X-G motif; other site
696747011524	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
696747011525	Mg2+ binding site [ion binding]; other site
696747011526	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
696747011527	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747011528	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747011529	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747011530	dimer interface [polypeptide binding]; other site
696747011531	phosphorylation site [posttranslational modification]
696747011532	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747011533	GAF domain; Region: GAF; pfam01590
696747011534	GAF domain; Region: GAF; cl17456
696747011535	Response regulator receiver domain; Region: Response_reg; pfam00072
696747011536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747011537	active site
696747011538	phosphorylation site [posttranslational modification]
696747011539	intermolecular recognition site; other site
696747011540	dimerization interface [polypeptide binding]; other site
696747011541	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
696747011542	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747011543	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
696747011544	protein binding site [polypeptide binding]; other site
696747011545	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
696747011546	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
696747011547	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
696747011548	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
696747011549	active site
696747011550	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
696747011551	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
696747011552	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
696747011553	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
696747011554	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747011555	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747011556	Probable transposase; Region: OrfB_IS605; pfam01385
696747011557	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
696747011558	DNA binding residues [nucleotide binding]
696747011559	PAS domain S-box; Region: sensory_box; TIGR00229
696747011560	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747011561	putative active site [active]
696747011562	heme pocket [chemical binding]; other site
696747011563	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747011564	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747011565	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747011566	metal binding site [ion binding]; metal-binding site
696747011567	active site
696747011568	I-site; other site
696747011569	Hemolysin-type calcium-binding repeat (2 copies); Region: HemolysinCabind; pfam00353
696747011570	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
696747011571	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
696747011572	Phage tail repeat like; Region: PTR; pfam12789
696747011573	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747011574	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
696747011575	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
696747011576	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
696747011577	Nuclease-related domain; Region: NERD; pfam08378
696747011578	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
696747011579	Family description; Region: UvrD_C_2; pfam13538
696747011580	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
696747011581	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
696747011582	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
696747011583	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
696747011584	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
696747011585	glycogen synthase; Provisional; Region: glgA; PRK00654
696747011586	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
696747011587	ADP-binding pocket [chemical binding]; other site
696747011588	homodimer interface [polypeptide binding]; other site
696747011589	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011590	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747011591	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011592	putative active site [active]
696747011593	putative NTP binding site [chemical binding]; other site
696747011594	putative nucleic acid binding site [nucleotide binding]; other site
696747011595	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747011596	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747011597	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747011598	active site
696747011599	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
696747011600	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011601	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011602	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011603	putative NTP binding site [chemical binding]; other site
696747011604	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011605	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747011606	putative active site [active]
696747011607	putative nucleic acid binding site [nucleotide binding]; other site
696747011608	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747011609	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747011610	active site
696747011611	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
696747011612	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
696747011613	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
696747011614	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747011615	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747011616	active site
696747011617	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011618	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747011619	putative active site [active]
696747011620	putative nucleic acid binding site [nucleotide binding]; other site
696747011621	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747011622	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011623	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011624	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011625	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011626	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747011627	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011628	putative active site [active]
696747011629	putative NTP binding site [chemical binding]; other site
696747011630	putative nucleic acid binding site [nucleotide binding]; other site
696747011631	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747011632	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747011633	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747011634	active site
696747011635	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
696747011636	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
696747011637	ligand binding site [chemical binding]; other site
696747011638	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
696747011639	Rab subfamily motif 1 (RabSF1); other site
696747011640	G1 box; other site
696747011641	GTP/Mg2+ binding site [chemical binding]; other site
696747011642	Rab subfamily motif 2 (RabSF2); other site
696747011643	Switch I region; other site
696747011644	G2 box; other site
696747011645	effector interaction site; other site
696747011646	GDI interaction site; other site
696747011647	Rab family motif 1 (RabF1); other site
696747011648	GEF interaction site [polypeptide binding]; other site
696747011649	Rab family motif 2 (RabF2); other site
696747011650	G3 box; other site
696747011651	Switch II region; other site
696747011652	Rab family motif 3 (RabF3); other site
696747011653	Rab family motif 4 (RabF4); other site
696747011654	Rab family motif 5 (RabF5); other site
696747011655	Rab subfamily motif 3 (RabSF3); other site
696747011656	G4 box; other site
696747011657	G5 box; other site
696747011658	PAS domain S-box; Region: sensory_box; TIGR00229
696747011659	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747011660	putative active site [active]
696747011661	heme pocket [chemical binding]; other site
696747011662	cyclase homology domain; Region: CHD; cd07302
696747011663	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
696747011664	dimer interface [polypeptide binding]; other site
696747011665	nucleotidyl binding site; other site
696747011666	metal binding site [ion binding]; metal-binding site
696747011667	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
696747011668	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
696747011669	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
696747011670	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
696747011671	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747011672	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
696747011673	DXD motif; other site
696747011674	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747011675	putative active site [active]
696747011676	Winged helix-turn helix; Region: HTH_29; pfam13551
696747011677	Homeodomain-like domain; Region: HTH_23; cl17451
696747011678	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747011679	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747011680	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011681	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
696747011682	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
696747011683	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696747011684	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
696747011685	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
696747011686	DNA binding residues [nucleotide binding]
696747011687	dimer interface [polypeptide binding]; other site
696747011688	metal binding site [ion binding]; metal-binding site
696747011689	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011690	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747011691	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011692	putative active site [active]
696747011693	putative NTP binding site [chemical binding]; other site
696747011694	putative nucleic acid binding site [nucleotide binding]; other site
696747011695	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011696	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011697	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011698	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747011699	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011700	putative NTP binding site [chemical binding]; other site
696747011701	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011702	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747011703	putative active site [active]
696747011704	putative nucleic acid binding site [nucleotide binding]; other site
696747011705	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747011706	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747011707	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747011708	active site
696747011709	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747011710	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747011711	putative active site [active]
696747011712	putative nucleic acid binding site [nucleotide binding]; other site
696747011713	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747011714	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747011715	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747011716	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747011717	active site
696747011718	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747011719	Homeodomain-like domain; Region: HTH_23; pfam13384
696747011720	Winged helix-turn helix; Region: HTH_33; pfam13592
696747011721	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747011722	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747011723	RRXRR protein; Region: RRXRR; pfam14239
696747011724	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
696747011725	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
696747011726	catalytic motif [active]
696747011727	Catalytic residue [active]
696747011728	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747011729	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
696747011730	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
696747011731	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
696747011732	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
696747011733	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
696747011734	Surface antigen; Region: Bac_surface_Ag; pfam01103
696747011735	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
696747011736	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
696747011737	P-loop; other site
696747011738	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
696747011739	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
696747011740	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
696747011741	threonine dehydratase; Reviewed; Region: PRK09224
696747011742	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
696747011743	tetramer interface [polypeptide binding]; other site
696747011744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747011745	catalytic residue [active]
696747011746	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
696747011747	putative Ile/Val binding site [chemical binding]; other site
696747011748	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
696747011749	putative Ile/Val binding site [chemical binding]; other site
696747011750	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747011751	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747011752	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747011753	dimer interface [polypeptide binding]; other site
696747011754	phosphorylation site [posttranslational modification]
696747011755	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747011756	ATP binding site [chemical binding]; other site
696747011757	Mg2+ binding site [ion binding]; other site
696747011758	G-X-G motif; other site
696747011759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747011760	active site
696747011761	phosphorylation site [posttranslational modification]
696747011762	intermolecular recognition site; other site
696747011763	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747011764	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747011765	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747011766	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747011767	putative active site [active]
696747011768	heme pocket [chemical binding]; other site
696747011769	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747011770	putative active site [active]
696747011771	heme pocket [chemical binding]; other site
696747011772	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747011773	PAS fold; Region: PAS_3; pfam08447
696747011774	putative active site [active]
696747011775	heme pocket [chemical binding]; other site
696747011776	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747011777	PAS fold; Region: PAS_3; pfam08447
696747011778	putative active site [active]
696747011779	heme pocket [chemical binding]; other site
696747011780	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
696747011781	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
696747011782	active site
696747011783	HIGH motif; other site
696747011784	dimer interface [polypeptide binding]; other site
696747011785	KMSKS motif; other site
696747011786	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
696747011787	FAD binding site [chemical binding]; other site
696747011788	Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229
696747011789	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696747011790	Peptidase family M23; Region: Peptidase_M23; pfam01551
696747011791	CHASE4 domain; Region: CHASE4; pfam05228
696747011792	HAMP domain; Region: HAMP; pfam00672
696747011793	dimerization interface [polypeptide binding]; other site
696747011794	PAS domain S-box; Region: sensory_box; TIGR00229
696747011795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747011796	putative active site [active]
696747011797	heme pocket [chemical binding]; other site
696747011798	GAF domain; Region: GAF_3; pfam13492
696747011799	GAF domain; Region: GAF_2; pfam13185
696747011800	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747011801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747011802	dimer interface [polypeptide binding]; other site
696747011803	phosphorylation site [posttranslational modification]
696747011804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747011805	ATP binding site [chemical binding]; other site
696747011806	Mg2+ binding site [ion binding]; other site
696747011807	G-X-G motif; other site
696747011808	Response regulator receiver domain; Region: Response_reg; pfam00072
696747011809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747011810	active site
696747011811	phosphorylation site [posttranslational modification]
696747011812	intermolecular recognition site; other site
696747011813	Response regulator receiver domain; Region: Response_reg; pfam00072
696747011814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747011815	active site
696747011816	phosphorylation site [posttranslational modification]
696747011817	intermolecular recognition site; other site
696747011818	dimerization interface [polypeptide binding]; other site
696747011819	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
696747011820	putative binding surface; other site
696747011821	active site
696747011822	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696747011823	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
696747011824	classical (c) SDRs; Region: SDR_c; cd05233
696747011825	NAD(P) binding site [chemical binding]; other site
696747011826	active site
696747011827	short chain dehydrogenase; Provisional; Region: PRK08303
696747011828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747011829	NAD(P) binding site [chemical binding]; other site
696747011830	active site
696747011831	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696747011832	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
696747011833	putative NAD(P) binding site [chemical binding]; other site
696747011834	active site
696747011835	Cache domain; Region: Cache_1; pfam02743
696747011836	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747011837	dimerization interface [polypeptide binding]; other site
696747011838	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
696747011839	cyclase homology domain; Region: CHD; cd07302
696747011840	nucleotidyl binding site; other site
696747011841	metal binding site [ion binding]; metal-binding site
696747011842	dimer interface [polypeptide binding]; other site
696747011843	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747011844	putative active site [active]
696747011845	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747011846	putative active site [active]
696747011847	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
696747011848	putative catalytic site [active]
696747011849	putative phosphate binding site [ion binding]; other site
696747011850	active site
696747011851	metal binding site A [ion binding]; metal-binding site
696747011852	DNA binding site [nucleotide binding]
696747011853	putative AP binding site [nucleotide binding]; other site
696747011854	putative metal binding site B [ion binding]; other site
696747011855	AAA domain; Region: AAA_21; pfam13304
696747011856	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
696747011857	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
696747011858	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
696747011859	oligomeric interface; other site
696747011860	putative active site [active]
696747011861	homodimer interface [polypeptide binding]; other site
696747011862	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
696747011863	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
696747011864	HIGH motif; other site
696747011865	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
696747011866	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
696747011867	active site
696747011868	KMSKS motif; other site
696747011869	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
696747011870	tRNA binding surface [nucleotide binding]; other site
696747011871	anticodon binding site; other site
696747011872	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
696747011873	Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139
696747011874	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
696747011875	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
696747011876	ATP cone domain; Region: ATP-cone; pfam03477
696747011877	ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506
696747011878	Class I ribonucleotide reductase; Region: RNR_I; cd01679
696747011879	active site
696747011880	dimer interface [polypeptide binding]; other site
696747011881	catalytic residues [active]
696747011882	effector binding site; other site
696747011883	R2 peptide binding site; other site
696747011884	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
696747011885	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
696747011886	putative radical transfer pathway; other site
696747011887	diiron center [ion binding]; other site
696747011888	dimer interface [polypeptide binding]; other site
696747011889	tyrosyl radical; other site
696747011890	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
696747011891	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
696747011892	active site
696747011893	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
696747011894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747011895	active site
696747011896	phosphorylation site [posttranslational modification]
696747011897	intermolecular recognition site; other site
696747011898	dimerization interface [polypeptide binding]; other site
696747011899	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696747011900	DNA binding residues [nucleotide binding]
696747011901	dimerization interface [polypeptide binding]; other site
696747011902	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
696747011903	PHP domain; Region: PHP; pfam02811
696747011904	active site
696747011905	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
696747011906	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
696747011907	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
696747011908	TrkA-N domain; Region: TrkA_N; pfam02254
696747011909	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
696747011910	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
696747011911	active site
696747011912	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747011913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747011914	S-adenosylmethionine binding site [chemical binding]; other site
696747011915	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
696747011916	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696747011917	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
696747011918	TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949
696747011919	catalytic residues [active]
696747011920	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
696747011921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747011922	dimer interface [polypeptide binding]; other site
696747011923	conserved gate region; other site
696747011924	ABC-ATPase subunit interface; other site
696747011925	RNA polymerase sigma factor RpoD; Validated; Region: PRK07406
696747011926	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
696747011927	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696747011928	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
696747011929	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696747011930	DNA binding residues [nucleotide binding]
696747011931	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
696747011932	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
696747011933	NAD(P) binding site [chemical binding]; other site
696747011934	catalytic residues [active]
696747011935	acetolactate synthase; Reviewed; Region: PRK08322
696747011936	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
696747011937	PYR/PP interface [polypeptide binding]; other site
696747011938	dimer interface [polypeptide binding]; other site
696747011939	TPP binding site [chemical binding]; other site
696747011940	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
696747011941	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
696747011942	TPP-binding site [chemical binding]; other site
696747011943	dimer interface [polypeptide binding]; other site
696747011944	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
696747011945	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
696747011946	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
696747011947	GMP synthase; Reviewed; Region: guaA; PRK00074
696747011948	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
696747011949	AMP/PPi binding site [chemical binding]; other site
696747011950	candidate oxyanion hole; other site
696747011951	catalytic triad [active]
696747011952	potential glutamine specificity residues [chemical binding]; other site
696747011953	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
696747011954	ATP Binding subdomain [chemical binding]; other site
696747011955	Ligand Binding sites [chemical binding]; other site
696747011956	Dimerization subdomain; other site
696747011957	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
696747011958	MgtE intracellular N domain; Region: MgtE_N; smart00924
696747011959	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
696747011960	Divalent cation transporter; Region: MgtE; pfam01769
696747011961	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
696747011962	MgtC family; Region: MgtC; pfam02308
696747011963	trehalose synthase; Region: treS_nterm; TIGR02456
696747011964	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
696747011965	active site
696747011966	catalytic site [active]
696747011967	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
696747011968	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
696747011969	dihydroorotase; Provisional; Region: PRK07575
696747011970	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
696747011971	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
696747011972	active site
696747011973	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
696747011974	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
696747011975	putative catalytic cysteine [active]
696747011976	Circadian oscillating protein COP23; Region: COP23; pfam14218
696747011977	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
696747011978	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747011979	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747011980	Response regulator receiver domain; Region: Response_reg; pfam00072
696747011981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747011982	active site
696747011983	phosphorylation site [posttranslational modification]
696747011984	intermolecular recognition site; other site
696747011985	dimerization interface [polypeptide binding]; other site
696747011986	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747011987	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747011988	dimer interface [polypeptide binding]; other site
696747011989	phosphorylation site [posttranslational modification]
696747011990	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747011991	ATP binding site [chemical binding]; other site
696747011992	Mg2+ binding site [ion binding]; other site
696747011993	G-X-G motif; other site
696747011994	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
696747011995	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
696747011996	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
696747011997	dimer interface [polypeptide binding]; other site
696747011998	active site
696747011999	glycine-pyridoxal phosphate binding site [chemical binding]; other site
696747012000	folate binding site [chemical binding]; other site
696747012001	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
696747012002	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
696747012003	Mg++ binding site [ion binding]; other site
696747012004	putative catalytic motif [active]
696747012005	substrate binding site [chemical binding]; other site
696747012006	competence damage-inducible protein A; Provisional; Region: PRK00549
696747012007	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
696747012008	putative MPT binding site; other site
696747012009	Competence-damaged protein; Region: CinA; pfam02464
696747012010	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
696747012011	Dehydroquinase class II; Region: DHquinase_II; pfam01220
696747012012	trimer interface [polypeptide binding]; other site
696747012013	active site
696747012014	dimer interface [polypeptide binding]; other site
696747012015	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
696747012016	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
696747012017	Zn2+ binding site [ion binding]; other site
696747012018	Mg2+ binding site [ion binding]; other site
696747012019	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696747012020	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
696747012021	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
696747012022	HIGH motif; other site
696747012023	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
696747012024	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
696747012025	active site
696747012026	KMSKS motif; other site
696747012027	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
696747012028	tRNA binding surface [nucleotide binding]; other site
696747012029	High-affinity nickel-transport protein; Region: NicO; cl00964
696747012030	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
696747012031	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
696747012032	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
696747012033	motif 1; other site
696747012034	active site
696747012035	motif 2; other site
696747012036	motif 3; other site
696747012037	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
696747012038	AAA domain; Region: AAA_21; pfam13304
696747012039	RloB-like protein; Region: RloB; pfam13707
696747012040	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
696747012041	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
696747012042	active site
696747012043	CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cd09740
696747012044	CRISPR-associated protein, TIGR03985 family; Region: TIGR03985
696747012045	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
696747012046	Family description; Region: UvrD_C_2; pfam13538
696747012047	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
696747012048	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
696747012049	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
696747012050	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
696747012051	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
696747012052	hydrolase, alpha/beta fold family protein; Region: PLN02824
696747012053	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
696747012054	DEAD-like helicases superfamily; Region: DEXDc; smart00487
696747012055	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747012056	ATP binding site [chemical binding]; other site
696747012057	putative Mg++ binding site [ion binding]; other site
696747012058	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747012059	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
696747012060	nucleotide binding region [chemical binding]; other site
696747012061	ATP-binding site [chemical binding]; other site
696747012062	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
696747012063	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
696747012064	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
696747012065	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
696747012066	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
696747012067	Protein of unknown function (DUF499); Region: DUF499; pfam04465
696747012068	MEKHLA domain; Region: MEKHLA; pfam08670
696747012069	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
696747012070	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
696747012071	putative active site [active]
696747012072	Zn binding site [ion binding]; other site
696747012073	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
696747012074	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
696747012075	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
696747012076	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
696747012077	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696747012078	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696747012079	Peptidase family M23; Region: Peptidase_M23; pfam01551
696747012080	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747012081	Switch II region; other site
696747012082	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747012083	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747012084	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747012085	putative active site [active]
696747012086	putative NTP binding site [chemical binding]; other site
696747012087	putative nucleic acid binding site [nucleotide binding]; other site
696747012088	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747012089	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747012090	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747012091	active site
696747012092	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
696747012093	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747012094	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747012095	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747012096	putative active site [active]
696747012097	putative NTP binding site [chemical binding]; other site
696747012098	putative nucleic acid binding site [nucleotide binding]; other site
696747012099	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747012100	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747012101	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747012102	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747012103	putative NTP binding site [chemical binding]; other site
696747012104	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747012105	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747012106	putative active site [active]
696747012107	putative nucleic acid binding site [nucleotide binding]; other site
696747012108	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747012109	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747012110	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747012111	active site
696747012112	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
696747012113	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
696747012114	dimer interface [polypeptide binding]; other site
696747012115	decamer (pentamer of dimers) interface [polypeptide binding]; other site
696747012116	catalytic triad [active]
696747012117	peroxidatic and resolving cysteines [active]
696747012118	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
696747012119	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
696747012120	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747012121	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747012122	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747012123	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747012124	putative active site [active]
696747012125	putative NTP binding site [chemical binding]; other site
696747012126	putative nucleic acid binding site [nucleotide binding]; other site
696747012127	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747012128	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747012129	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747012130	active site
696747012131	hydrolase, alpha/beta fold family protein; Region: PLN02824
696747012132	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
696747012133	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
696747012134	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
696747012135	TLC ATP/ADP transporter; Region: TLC; cl03940
696747012136	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
696747012137	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696747012138	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747012139	ligand binding site [chemical binding]; other site
696747012140	flexible hinge region; other site
696747012141	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
696747012142	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
696747012143	G1 box; other site
696747012144	putative GEF interaction site [polypeptide binding]; other site
696747012145	GTP/Mg2+ binding site [chemical binding]; other site
696747012146	Switch I region; other site
696747012147	G2 box; other site
696747012148	G3 box; other site
696747012149	Switch II region; other site
696747012150	G4 box; other site
696747012151	G5 box; other site
696747012152	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
696747012153	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
696747012154	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
696747012155	Walker A/P-loop; other site
696747012156	ATP binding site [chemical binding]; other site
696747012157	Q-loop/lid; other site
696747012158	ABC transporter signature motif; other site
696747012159	Walker B; other site
696747012160	D-loop; other site
696747012161	H-loop/switch region; other site
696747012162	TOBE domain; Region: TOBE_2; pfam08402
696747012163	DNA gyrase subunit A; Validated; Region: PRK05560
696747012164	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
696747012165	CAP-like domain; other site
696747012166	active site
696747012167	primary dimer interface [polypeptide binding]; other site
696747012168	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696747012169	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
696747012170	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747012171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747012172	active site
696747012173	phosphorylation site [posttranslational modification]
696747012174	intermolecular recognition site; other site
696747012175	dimerization interface [polypeptide binding]; other site
696747012176	TPR repeat; Region: TPR_11; pfam13414
696747012177	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012178	binding surface
696747012179	TPR motif; other site
696747012180	TPR repeat; Region: TPR_11; pfam13414
696747012181	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747012182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012183	binding surface
696747012184	TPR motif; other site
696747012185	TPR repeat; Region: TPR_11; pfam13414
696747012186	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747012187	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747012188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747012189	ATP binding site [chemical binding]; other site
696747012190	Mg2+ binding site [ion binding]; other site
696747012191	G-X-G motif; other site
696747012192	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747012193	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747012194	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747012195	CTP synthetase; Validated; Region: pyrG; PRK05380
696747012196	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
696747012197	Catalytic site [active]
696747012198	active site
696747012199	UTP binding site [chemical binding]; other site
696747012200	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
696747012201	active site
696747012202	putative oxyanion hole; other site
696747012203	catalytic triad [active]
696747012204	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
696747012205	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696747012206	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
696747012207	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
696747012208	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
696747012209	ATP binding site [chemical binding]; other site
696747012210	putative Mg++ binding site [ion binding]; other site
696747012211	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
696747012212	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
696747012213	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
696747012214	Restriction endonuclease; Region: Mrr_cat; pfam04471
696747012215	DNA methylase; Region: N6_N4_Mtase; pfam01555
696747012216	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
696747012217	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
696747012218	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
696747012219	Probable transposase; Region: OrfB_IS605; pfam01385
696747012220	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747012221	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747012222	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747012223	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747012224	Probable transposase; Region: OrfB_IS605; pfam01385
696747012225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
696747012226	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
696747012227	active site
696747012228	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747012229	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747012230	putative active site [active]
696747012231	putative nucleic acid binding site [nucleotide binding]; other site
696747012232	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747012233	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747012234	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747012235	active site
696747012236	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747012237	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747012238	putative NTP binding site [chemical binding]; other site
696747012239	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747012240	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747012241	Switch II region; other site
696747012242	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747012243	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747012244	GAF domain; Region: GAF; pfam01590
696747012245	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747012246	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747012247	putative active site [active]
696747012248	heme pocket [chemical binding]; other site
696747012249	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747012250	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747012251	putative active site [active]
696747012252	heme pocket [chemical binding]; other site
696747012253	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747012254	putative active site [active]
696747012255	heme pocket [chemical binding]; other site
696747012256	GAF domain; Region: GAF_3; pfam13492
696747012257	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747012258	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747012259	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747012260	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747012261	dimer interface [polypeptide binding]; other site
696747012262	phosphorylation site [posttranslational modification]
696747012263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747012264	ATP binding site [chemical binding]; other site
696747012265	Mg2+ binding site [ion binding]; other site
696747012266	G-X-G motif; other site
696747012267	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
696747012268	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
696747012269	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
696747012270	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
696747012271	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
696747012272	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747012273	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747012274	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747012275	putative active site [active]
696747012276	putative NTP binding site [chemical binding]; other site
696747012277	putative nucleic acid binding site [nucleotide binding]; other site
696747012278	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747012279	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747012280	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747012281	active site
696747012282	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747012283	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747012284	putative NTP binding site [chemical binding]; other site
696747012285	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747012286	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747012287	putative active site [active]
696747012288	putative nucleic acid binding site [nucleotide binding]; other site
696747012289	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747012290	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747012291	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747012292	active site
696747012293	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747012294	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747012295	MORN repeat; Region: MORN; cl14787
696747012296	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
696747012297	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
696747012298	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
696747012299	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
696747012300	DNA binding site [nucleotide binding]
696747012301	catalytic residue [active]
696747012302	H2TH interface [polypeptide binding]; other site
696747012303	putative catalytic residues [active]
696747012304	turnover-facilitating residue; other site
696747012305	intercalation triad [nucleotide binding]; other site
696747012306	8OG recognition residue [nucleotide binding]; other site
696747012307	putative reading head residues; other site
696747012308	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
696747012309	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
696747012310	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
696747012311	malate dehydrogenase; Reviewed; Region: PRK06223
696747012312	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
696747012313	NAD(P) binding site [chemical binding]; other site
696747012314	dimer interface [polypeptide binding]; other site
696747012315	tetramer (dimer of dimers) interface [polypeptide binding]; other site
696747012316	substrate binding site [chemical binding]; other site
696747012317	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747012318	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747012319	active site
696747012320	ATP binding site [chemical binding]; other site
696747012321	substrate binding site [chemical binding]; other site
696747012322	activation loop (A-loop); other site
696747012323	Uncharacterized conserved protein [Function unknown]; Region: COG1262
696747012324	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
696747012325	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012326	TPR motif; other site
696747012327	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747012328	binding surface
696747012329	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012330	binding surface
696747012331	TPR motif; other site
696747012332	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747012333	Probable transposase; Region: OrfB_IS605; pfam01385
696747012334	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747012335	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
696747012336	DNA binding residues [nucleotide binding]
696747012337	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
696747012338	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
696747012339	catalytic residues [active]
696747012340	catalytic nucleophile [active]
696747012341	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
696747012342	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
696747012343	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
696747012344	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
696747012345	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
696747012346	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
696747012347	CRISPR-associated protein; Region: DUF3692; pfam12469
696747012348	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
696747012349	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
696747012350	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747012351	FeS/SAM binding site; other site
696747012352	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
696747012353	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
696747012354	dimerization interface [polypeptide binding]; other site
696747012355	domain crossover interface; other site
696747012356	redox-dependent activation switch; other site
696747012357	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747012358	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747012359	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747012360	DevC protein; Region: devC; TIGR01185
696747012361	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
696747012362	FtsX-like permease family; Region: FtsX; pfam02687
696747012363	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
696747012364	YcfA-like protein; Region: YcfA; pfam07927
696747012365	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
696747012366	oligomeric interface; other site
696747012367	putative active site [active]
696747012368	homodimer interface [polypeptide binding]; other site
696747012369	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
696747012370	Mechanosensitive ion channel; Region: MS_channel; pfam00924
696747012371	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
696747012372	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747012373	dimer interface [polypeptide binding]; other site
696747012374	conserved gate region; other site
696747012375	putative PBP binding loops; other site
696747012376	ABC-ATPase subunit interface; other site
696747012377	sulfate transport protein; Provisional; Region: cysT; CHL00187
696747012378	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747012379	dimer interface [polypeptide binding]; other site
696747012380	conserved gate region; other site
696747012381	putative PBP binding loops; other site
696747012382	ABC-ATPase subunit interface; other site
696747012383	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
696747012384	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
696747012385	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
696747012386	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
696747012387	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
696747012388	Walker A/P-loop; other site
696747012389	ATP binding site [chemical binding]; other site
696747012390	Q-loop/lid; other site
696747012391	ABC transporter signature motif; other site
696747012392	Walker B; other site
696747012393	D-loop; other site
696747012394	H-loop/switch region; other site
696747012395	Domain of unknown function (DUF202); Region: DUF202; cl09954
696747012396	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
696747012397	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696747012398	ligand binding site [chemical binding]; other site
696747012399	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
696747012400	non-specific DNA interactions [nucleotide binding]; other site
696747012401	DNA binding site [nucleotide binding]
696747012402	sequence specific DNA binding site [nucleotide binding]; other site
696747012403	putative cAMP binding site [chemical binding]; other site
696747012404	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
696747012405	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
696747012406	dimer interface [polypeptide binding]; other site
696747012407	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747012408	catalytic residue [active]
696747012409	serine O-acetyltransferase; Region: cysE; TIGR01172
696747012410	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
696747012411	trimer interface [polypeptide binding]; other site
696747012412	active site
696747012413	substrate binding site [chemical binding]; other site
696747012414	CoA binding site [chemical binding]; other site
696747012415	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
696747012416	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
696747012417	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696747012418	catalytic residue [active]
696747012419	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
696747012420	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
696747012421	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
696747012422	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
696747012423	CoA binding domain; Region: CoA_binding_2; pfam13380
696747012424	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
696747012425	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
696747012426	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
696747012427	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696747012428	Coenzyme A binding pocket [chemical binding]; other site
696747012429	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
696747012430	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
696747012431	C-terminal domain interface [polypeptide binding]; other site
696747012432	active site
696747012433	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
696747012434	active site
696747012435	N-terminal domain interface [polypeptide binding]; other site
696747012436	Phosphate transporter family; Region: PHO4; pfam01384
696747012437	Phosphate transporter family; Region: PHO4; pfam01384
696747012438	Right handed beta helix region; Region: Beta_helix; pfam13229
696747012439	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
696747012440	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
696747012441	S-layer homology domain; Region: SLH; pfam00395
696747012442	S-layer homology domain; Region: SLH; pfam00395
696747012443	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696747012444	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747012445	S-adenosylmethionine binding site [chemical binding]; other site
696747012446	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
696747012447	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
696747012448	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
696747012449	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
696747012450	homodimer interface [polypeptide binding]; other site
696747012451	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
696747012452	active site pocket [active]
696747012453	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747012454	Switch II region; other site
696747012455	G4 box; other site
696747012456	G5 box; other site
696747012457	Domain of unknown function (DUF697); Region: DUF697; pfam05128
696747012458	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
696747012459	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
696747012460	active site
696747012461	metal binding site [ion binding]; metal-binding site
696747012462	RRXRR protein; Region: RRXRR; pfam14239
696747012463	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
696747012464	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
696747012465	Patatin-like phospholipase of bacteria; Region: Pat17_PNPLA8_PNPLA9_like2; cd07215
696747012466	active site
696747012467	nucleophile elbow; other site
696747012468	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
696747012469	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747012470	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
696747012471	RRXRR protein; Region: RRXRR; pfam14239
696747012472	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747012473	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747012474	active site
696747012475	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
696747012476	Sporulation and spore germination; Region: Germane; pfam10646
696747012477	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
696747012478	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
696747012479	ThiF family; Region: ThiF; pfam00899
696747012480	ATP binding site [chemical binding]; other site
696747012481	substrate interface [chemical binding]; other site
696747012482	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
696747012483	TPR repeat; Region: TPR_11; pfam13414
696747012484	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012485	binding surface
696747012486	TPR motif; other site
696747012487	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747012488	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747012489	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012490	binding surface
696747012491	TPR motif; other site
696747012492	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747012493	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747012494	Tetratricopeptide repeat; Region: TPR_10; cl17452
696747012495	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012496	binding surface
696747012497	TPR motif; other site
696747012498	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747012499	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747012500	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012501	binding surface
696747012502	TPR motif; other site
696747012503	CHAT domain; Region: CHAT; cl17868
696747012504	CHAT domain; Region: CHAT; cl17868
696747012505	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
696747012506	CHASE2 domain; Region: CHASE2; pfam05226
696747012507	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
696747012508	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747012509	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747012510	active site
696747012511	ATP binding site [chemical binding]; other site
696747012512	substrate binding site [chemical binding]; other site
696747012513	activation loop (A-loop); other site
696747012514	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
696747012515	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747012516	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747012517	phosphopeptide binding site; other site
696747012518	Double zinc ribbon; Region: DZR; pfam12773
696747012519	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747012520	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747012521	active site
696747012522	ATP binding site [chemical binding]; other site
696747012523	substrate binding site [chemical binding]; other site
696747012524	activation loop (A-loop); other site
696747012525	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
696747012526	Protein phosphatase 2C; Region: PP2C; pfam00481
696747012527	active site
696747012528	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
696747012529	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
696747012530	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
696747012531	PAS domain S-box; Region: sensory_box; TIGR00229
696747012532	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747012533	putative active site [active]
696747012534	heme pocket [chemical binding]; other site
696747012535	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747012536	GAF domain; Region: GAF; pfam01590
696747012537	PAS domain S-box; Region: sensory_box; TIGR00229
696747012538	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747012539	putative active site [active]
696747012540	heme pocket [chemical binding]; other site
696747012541	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747012542	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747012543	metal binding site [ion binding]; metal-binding site
696747012544	active site
696747012545	I-site; other site
696747012546	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747012547	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
696747012548	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
696747012549	Walker A/P-loop; other site
696747012550	ATP binding site [chemical binding]; other site
696747012551	Q-loop/lid; other site
696747012552	ABC transporter signature motif; other site
696747012553	Walker B; other site
696747012554	D-loop; other site
696747012555	H-loop/switch region; other site
696747012556	Cobalt transport protein; Region: CbiQ; cl00463
696747012557	cobalt transport protein CbiN; Provisional; Region: PRK02898
696747012558	cobalt transport protein CbiM; Validated; Region: PRK08319
696747012559	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
696747012560	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747012561	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747012562	active site
696747012563	argininosuccinate synthase; Provisional; Region: PRK13820
696747012564	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
696747012565	ANP binding site [chemical binding]; other site
696747012566	Substrate Binding Site II [chemical binding]; other site
696747012567	Substrate Binding Site I [chemical binding]; other site
696747012568	acyl-ACP reductase; Provisional; Region: PRK14982
696747012569	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
696747012570	NAD(P) binding pocket [chemical binding]; other site
696747012571	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
696747012572	dinuclear metal binding motif [ion binding]; other site
696747012573	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
696747012574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747012575	dimer interface [polypeptide binding]; other site
696747012576	conserved gate region; other site
696747012577	putative PBP binding loops; other site
696747012578	ABC-ATPase subunit interface; other site
696747012579	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
696747012580	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747012581	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
696747012582	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747012583	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747012584	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747012585	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747012586	PAS fold; Region: PAS; pfam00989
696747012587	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747012588	putative active site [active]
696747012589	heme pocket [chemical binding]; other site
696747012590	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747012591	cyclase homology domain; Region: CHD; cd07302
696747012592	nucleotidyl binding site; other site
696747012593	metal binding site [ion binding]; metal-binding site
696747012594	dimer interface [polypeptide binding]; other site
696747012595	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
696747012596	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
696747012597	putative catalytic cysteine [active]
696747012598	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
696747012599	putative active site [active]
696747012600	metal binding site [ion binding]; metal-binding site
696747012601	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
696747012602	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696747012603	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
696747012604	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
696747012605	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696747012606	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
696747012607	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
696747012608	hypothetical protein; Provisional; Region: PRK07377
696747012609	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
696747012610	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
696747012611	ABC1 family; Region: ABC1; pfam03109
696747012612	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
696747012613	active site
696747012614	ATP binding site [chemical binding]; other site
696747012615	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
696747012616	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
696747012617	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
696747012618	SLBB domain; Region: SLBB; pfam10531
696747012619	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
696747012620	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
696747012621	glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398
696747012622	active site
696747012623	homotetramer interface [polypeptide binding]; other site
696747012624	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
696747012625	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
696747012626	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
696747012627	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
696747012628	Response regulator receiver domain; Region: Response_reg; pfam00072
696747012629	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747012630	active site
696747012631	phosphorylation site [posttranslational modification]
696747012632	intermolecular recognition site; other site
696747012633	dimerization interface [polypeptide binding]; other site
696747012634	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747012635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747012636	ATP binding site [chemical binding]; other site
696747012637	Mg2+ binding site [ion binding]; other site
696747012638	G-X-G motif; other site
696747012639	PAS fold; Region: PAS_4; pfam08448
696747012640	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747012641	putative active site [active]
696747012642	heme pocket [chemical binding]; other site
696747012643	PAS domain; Region: PAS_9; pfam13426
696747012644	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747012645	putative active site [active]
696747012646	heme pocket [chemical binding]; other site
696747012647	PAS fold; Region: PAS_4; pfam08448
696747012648	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747012649	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747012650	dimer interface [polypeptide binding]; other site
696747012651	phosphorylation site [posttranslational modification]
696747012652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747012653	ATP binding site [chemical binding]; other site
696747012654	Mg2+ binding site [ion binding]; other site
696747012655	G-X-G motif; other site
696747012656	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747012657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747012658	active site
696747012659	phosphorylation site [posttranslational modification]
696747012660	intermolecular recognition site; other site
696747012661	dimerization interface [polypeptide binding]; other site
696747012662	Response regulator receiver domain; Region: Response_reg; pfam00072
696747012663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747012664	active site
696747012665	phosphorylation site [posttranslational modification]
696747012666	intermolecular recognition site; other site
696747012667	dimerization interface [polypeptide binding]; other site
696747012668	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
696747012669	putative binding surface; other site
696747012670	active site
696747012671	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747012672	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747012673	metal binding site [ion binding]; metal-binding site
696747012674	active site
696747012675	I-site; other site
696747012676	Uncharacterized conserved protein [Function unknown]; Region: COG5439
696747012677	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
696747012678	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747012679	dimerization interface [polypeptide binding]; other site
696747012680	PAS domain S-box; Region: sensory_box; TIGR00229
696747012681	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747012682	putative active site [active]
696747012683	heme pocket [chemical binding]; other site
696747012684	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747012685	cyclase homology domain; Region: CHD; cd07302
696747012686	nucleotidyl binding site; other site
696747012687	metal binding site [ion binding]; metal-binding site
696747012688	dimer interface [polypeptide binding]; other site
696747012689	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
696747012690	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
696747012691	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
696747012692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747012693	dimer interface [polypeptide binding]; other site
696747012694	conserved gate region; other site
696747012695	putative PBP binding loops; other site
696747012696	ABC-ATPase subunit interface; other site
696747012697	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
696747012698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747012699	dimer interface [polypeptide binding]; other site
696747012700	conserved gate region; other site
696747012701	putative PBP binding loops; other site
696747012702	ABC-ATPase subunit interface; other site
696747012703	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
696747012704	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
696747012705	domain interfaces; other site
696747012706	active site
696747012707	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
696747012708	phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600
696747012709	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
696747012710	Walker A motif; other site
696747012711	ATP binding site [chemical binding]; other site
696747012712	Walker B motif; other site
696747012713	DNA binding loops [nucleotide binding]
696747012714	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
696747012715	protein-splicing catalytic site; other site
696747012716	thioester formation/cholesterol transfer; other site
696747012717	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
696747012718	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
696747012719	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
696747012720	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
696747012721	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
696747012722	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
696747012723	Walker A/P-loop; other site
696747012724	ATP binding site [chemical binding]; other site
696747012725	Q-loop/lid; other site
696747012726	ABC transporter signature motif; other site
696747012727	Walker B; other site
696747012728	D-loop; other site
696747012729	H-loop/switch region; other site
696747012730	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
696747012731	TrkA-N domain; Region: TrkA_N; pfam02254
696747012732	Cation transport protein; Region: TrkH; cl17365
696747012733	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
696747012734	TrkA-N domain; Region: TrkA_N; pfam02254
696747012735	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
696747012736	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
696747012737	Walker A/P-loop; other site
696747012738	ATP binding site [chemical binding]; other site
696747012739	Q-loop/lid; other site
696747012740	ABC transporter signature motif; other site
696747012741	Walker B; other site
696747012742	D-loop; other site
696747012743	H-loop/switch region; other site
696747012744	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
696747012745	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
696747012746	active site
696747012747	(T/H)XGH motif; other site
696747012748	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
696747012749	nudix motif; other site
696747012750	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
696747012751	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
696747012752	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
696747012753	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012754	TPR motif; other site
696747012755	TPR repeat; Region: TPR_11; pfam13414
696747012756	binding surface
696747012757	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
696747012758	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
696747012759	interchain domain interface [polypeptide binding]; other site
696747012760	intrachain domain interface; other site
696747012761	Qi binding site; other site
696747012762	Qo binding site; other site
696747012763	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
696747012764	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
696747012765	Qi binding site; other site
696747012766	intrachain domain interface; other site
696747012767	interchain domain interface [polypeptide binding]; other site
696747012768	heme bH binding site [chemical binding]; other site
696747012769	heme bL binding site [chemical binding]; other site
696747012770	Qo binding site; other site
696747012771	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
696747012772	Protein of unknown function (DUF790); Region: DUF790; pfam05626
696747012773	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
696747012774	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
696747012775	substrate binding site [chemical binding]; other site
696747012776	catalytic Zn binding site [ion binding]; other site
696747012777	NAD binding site [chemical binding]; other site
696747012778	structural Zn binding site [ion binding]; other site
696747012779	dimer interface [polypeptide binding]; other site
696747012780	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747012781	cofactor binding site; other site
696747012782	DNA binding site [nucleotide binding]
696747012783	substrate interaction site [chemical binding]; other site
696747012784	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747012785	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
696747012786	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747012787	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747012788	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
696747012789	Domain of unknown function DUF20; Region: UPF0118; pfam01594
696747012790	Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559
696747012791	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
696747012792	EamA-like transporter family; Region: EamA; pfam00892
696747012793	EamA-like transporter family; Region: EamA; pfam00892
696747012794	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
696747012795	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
696747012796	active site
696747012797	substrate binding site [chemical binding]; other site
696747012798	metal binding site [ion binding]; metal-binding site
696747012799	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
696747012800	homodecamer interface [polypeptide binding]; other site
696747012801	GTP cyclohydrolase I; Provisional; Region: PLN03044
696747012802	active site
696747012803	putative catalytic site residues [active]
696747012804	zinc binding site [ion binding]; other site
696747012805	GTP-CH-I/GFRP interaction surface; other site
696747012806	short chain dehydrogenase; Provisional; Region: PRK07454
696747012807	classical (c) SDRs; Region: SDR_c; cd05233
696747012808	NAD(P) binding site [chemical binding]; other site
696747012809	active site
696747012810	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
696747012811	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
696747012812	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
696747012813	metal binding site 2 [ion binding]; metal-binding site
696747012814	putative DNA binding helix; other site
696747012815	metal binding site 1 [ion binding]; metal-binding site
696747012816	dimer interface [polypeptide binding]; other site
696747012817	structural Zn2+ binding site [ion binding]; other site
696747012818	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
696747012819	catalytic triad [active]
696747012820	dimer interface [polypeptide binding]; other site
696747012821	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747012822	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747012823	active site
696747012824	ATP binding site [chemical binding]; other site
696747012825	substrate binding site [chemical binding]; other site
696747012826	activation loop (A-loop); other site
696747012827	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012828	TPR repeat; Region: TPR_11; pfam13414
696747012829	binding surface
696747012830	TPR motif; other site
696747012831	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012832	TPR motif; other site
696747012833	binding surface
696747012834	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747012835	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012836	binding surface
696747012837	TPR motif; other site
696747012838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012839	binding surface
696747012840	TPR motif; other site
696747012841	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
696747012842	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
696747012843	MOSC domain; Region: MOSC; pfam03473
696747012844	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
696747012845	EamA-like transporter family; Region: EamA; pfam00892
696747012846	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747012847	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747012848	active site
696747012849	ATP binding site [chemical binding]; other site
696747012850	substrate binding site [chemical binding]; other site
696747012851	activation loop (A-loop); other site
696747012852	UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186
696747012853	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
696747012854	ABC1 family; Region: ABC1; cl17513
696747012855	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
696747012856	active site
696747012857	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
696747012858	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
696747012859	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747012860	ATP binding site [chemical binding]; other site
696747012861	putative Mg++ binding site [ion binding]; other site
696747012862	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747012863	nucleotide binding region [chemical binding]; other site
696747012864	ATP-binding site [chemical binding]; other site
696747012865	hypothetical protein; Provisional; Region: PRK11770
696747012866	Domain of unknown function (DUF307); Region: DUF307; pfam03733
696747012867	Domain of unknown function (DUF307); Region: DUF307; pfam03733
696747012868	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747012869	TPR motif; other site
696747012870	TPR repeat; Region: TPR_11; pfam13414
696747012871	binding surface
696747012872	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
696747012873	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
696747012874	active site
696747012875	ADP/pyrophosphate binding site [chemical binding]; other site
696747012876	dimerization interface [polypeptide binding]; other site
696747012877	allosteric effector site; other site
696747012878	fructose-1,6-bisphosphate binding site; other site
696747012879	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
696747012880	D-xylulose kinase; Region: XylB; TIGR01312
696747012881	nucleotide binding site [chemical binding]; other site
696747012882	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
696747012883	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747012884	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747012885	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
696747012886	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
696747012887	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
696747012888	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
696747012889	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
696747012890	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747012891	dimerization interface [polypeptide binding]; other site
696747012892	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747012893	putative active site [active]
696747012894	heme pocket [chemical binding]; other site
696747012895	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747012896	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747012897	dimer interface [polypeptide binding]; other site
696747012898	phosphorylation site [posttranslational modification]
696747012899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747012900	ATP binding site [chemical binding]; other site
696747012901	Mg2+ binding site [ion binding]; other site
696747012902	G-X-G motif; other site
696747012903	phosphoglucomutase; Validated; Region: PRK07564
696747012904	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
696747012905	active site
696747012906	substrate binding site [chemical binding]; other site
696747012907	metal binding site [ion binding]; metal-binding site
696747012908	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
696747012909	alpha-mannosidase; Provisional; Region: PRK09819
696747012910	active site
696747012911	catalytic site [active]
696747012912	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
696747012913	Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640
696747012914	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
696747012915	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747012916	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747012917	active site
696747012918	ATP binding site [chemical binding]; other site
696747012919	substrate binding site [chemical binding]; other site
696747012920	activation loop (A-loop); other site
696747012921	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747012922	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747012923	structural tetrad; other site
696747012924	TMAO/DMSO reductase; Reviewed; Region: PRK05363
696747012925	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
696747012926	Moco binding site; other site
696747012927	metal coordination site [ion binding]; other site
696747012928	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
696747012929	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
696747012930	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
696747012931	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
696747012932	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
696747012933	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
696747012934	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
696747012935	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
696747012936	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
696747012937	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
696747012938	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
696747012939	NADH(P)-binding; Region: NAD_binding_10; pfam13460
696747012940	NAD(P) binding site [chemical binding]; other site
696747012941	putative active site [active]
696747012942	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
696747012943	catalytic residue [active]
696747012944	sulfotransferase; Region: PLN02164
696747012945	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
696747012946	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
696747012947	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
696747012948	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
696747012949	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
696747012950	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
696747012951	Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051
696747012952	Acyltransferase family; Region: Acyl_transf_3; pfam01757
696747012953	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
696747012954	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747012955	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
696747012956	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
696747012957	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696747012958	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
696747012959	Walker A/P-loop; other site
696747012960	ATP binding site [chemical binding]; other site
696747012961	Q-loop/lid; other site
696747012962	ABC transporter signature motif; other site
696747012963	Walker B; other site
696747012964	D-loop; other site
696747012965	H-loop/switch region; other site
696747012966	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747012967	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696747012968	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
696747012969	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
696747012970	Ligand binding site; other site
696747012971	Putative Catalytic site; other site
696747012972	DXD motif; other site
696747012973	Predicted membrane protein [Function unknown]; Region: COG2246
696747012974	GtrA-like protein; Region: GtrA; pfam04138
696747012975	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
696747012976	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
696747012977	catalytic residues [active]
696747012978	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
696747012979	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
696747012980	NAD(P) binding site [chemical binding]; other site
696747012981	homotetramer interface [polypeptide binding]; other site
696747012982	homodimer interface [polypeptide binding]; other site
696747012983	active site
696747012984	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
696747012985	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
696747012986	ring oligomerisation interface [polypeptide binding]; other site
696747012987	ATP/Mg binding site [chemical binding]; other site
696747012988	stacking interactions; other site
696747012989	hinge regions; other site
696747012990	Response regulator receiver domain; Region: Response_reg; pfam00072
696747012991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747012992	active site
696747012993	phosphorylation site [posttranslational modification]
696747012994	intermolecular recognition site; other site
696747012995	dimerization interface [polypeptide binding]; other site
696747012996	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747012997	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747012998	dimer interface [polypeptide binding]; other site
696747012999	phosphorylation site [posttranslational modification]
696747013000	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747013001	ATP binding site [chemical binding]; other site
696747013002	Mg2+ binding site [ion binding]; other site
696747013003	G-X-G motif; other site
696747013004	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747013005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747013006	active site
696747013007	phosphorylation site [posttranslational modification]
696747013008	intermolecular recognition site; other site
696747013009	dimerization interface [polypeptide binding]; other site
696747013010	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
696747013011	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747013012	dimer interface [polypeptide binding]; other site
696747013013	phosphorylation site [posttranslational modification]
696747013014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747013015	ATP binding site [chemical binding]; other site
696747013016	Mg2+ binding site [ion binding]; other site
696747013017	G-X-G motif; other site
696747013018	FOG: CBS domain [General function prediction only]; Region: COG0517
696747013019	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747013020	PAS fold; Region: PAS_4; pfam08448
696747013021	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747013022	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747013023	putative active site [active]
696747013024	heme pocket [chemical binding]; other site
696747013025	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747013026	putative active site [active]
696747013027	heme pocket [chemical binding]; other site
696747013028	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747013029	GAF domain; Region: GAF_3; pfam13492
696747013030	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
696747013031	Histidine kinase; Region: HisKA_2; pfam07568
696747013032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747013033	ATP binding site [chemical binding]; other site
696747013034	Mg2+ binding site [ion binding]; other site
696747013035	G-X-G motif; other site
696747013036	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747013037	TPR repeat; Region: TPR_11; pfam13414
696747013038	binding surface
696747013039	TPR motif; other site
696747013040	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747013041	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747013042	binding surface
696747013043	TPR motif; other site
696747013044	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747013045	binding surface
696747013046	TPR motif; other site
696747013047	Protein of unknown function (DUF563); Region: DUF563; pfam04577
696747013048	ribonuclease III; Reviewed; Region: rnc; PRK00102
696747013049	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
696747013050	dimerization interface [polypeptide binding]; other site
696747013051	active site
696747013052	metal binding site [ion binding]; metal-binding site
696747013053	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
696747013054	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
696747013055	metal ion-dependent adhesion site (MIDAS); other site
696747013056	Protein phosphatase 2C; Region: PP2C_2; pfam13672
696747013057	active site
696747013058	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013059	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747013060	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013061	putative active site [active]
696747013062	putative NTP binding site [chemical binding]; other site
696747013063	putative nucleic acid binding site [nucleotide binding]; other site
696747013064	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747013065	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747013066	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747013067	active site
696747013068	CHASE domain; Region: CHASE; cl01369
696747013069	PAS domain S-box; Region: sensory_box; TIGR00229
696747013070	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747013071	PAS fold; Region: PAS_3; pfam08447
696747013072	putative active site [active]
696747013073	heme pocket [chemical binding]; other site
696747013074	PAS domain; Region: PAS_9; pfam13426
696747013075	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747013076	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747013077	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747013078	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747013079	metal binding site [ion binding]; metal-binding site
696747013080	active site
696747013081	I-site; other site
696747013082	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
696747013083	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
696747013084	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
696747013085	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
696747013086	CHASE3 domain; Region: CHASE3; pfam05227
696747013087	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696747013088	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696747013089	dimer interface [polypeptide binding]; other site
696747013090	putative CheW interface [polypeptide binding]; other site
696747013091	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
696747013092	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
696747013093	substrate binding pocket [chemical binding]; other site
696747013094	chain length determination region; other site
696747013095	substrate-Mg2+ binding site; other site
696747013096	catalytic residues [active]
696747013097	aspartate-rich region 1; other site
696747013098	active site lid residues [active]
696747013099	aspartate-rich region 2; other site
696747013100	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
696747013101	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747013102	FeS/SAM binding site; other site
696747013103	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
696747013104	putative rRNA binding site [nucleotide binding]; other site
696747013105	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747013106	Probable transposase; Region: OrfB_IS605; pfam01385
696747013107	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747013108	Transposase IS200 like; Region: Y1_Tnp; pfam01797
696747013109	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747013110	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013111	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013112	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013113	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747013114	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013115	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013116	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747013117	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013118	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013119	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013120	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013121	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013122	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747013123	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013124	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
696747013125	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
696747013126	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
696747013127	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
696747013128	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
696747013129	Peptidase family M23; Region: Peptidase_M23; pfam01551
696747013130	Putative restriction endonuclease; Region: Uma2; pfam05685
696747013131	putative active site [active]
696747013132	Putative restriction endonuclease; Region: Uma2; pfam05685
696747013133	putative active site [active]
696747013134	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
696747013135	Low molecular weight phosphatase family; Region: LMWPc; cd00115
696747013136	active site
696747013137	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
696747013138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747013139	active site
696747013140	phosphorylation site [posttranslational modification]
696747013141	intermolecular recognition site; other site
696747013142	dimerization interface [polypeptide binding]; other site
696747013143	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696747013144	DNA binding residues [nucleotide binding]
696747013145	dimerization interface [polypeptide binding]; other site
696747013146	chaperone protein DnaJ; Provisional; Region: PRK14299
696747013147	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747013148	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013149	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013150	TPR repeat; Region: TPR_11; pfam13414
696747013151	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747013152	binding surface
696747013153	TPR motif; other site
696747013154	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
696747013155	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
696747013156	substrate binding pocket [chemical binding]; other site
696747013157	membrane-bound complex binding site; other site
696747013158	hinge residues; other site
696747013159	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
696747013160	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
696747013161	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013162	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013163	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747013164	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013165	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747013166	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013167	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747013168	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013169	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013170	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747013171	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013172	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013173	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013174	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013175	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013176	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013177	arogenate dehydrogenase; Reviewed; Region: PRK07417
696747013178	prephenate dehydrogenase; Validated; Region: PRK08507
696747013179	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
696747013180	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
696747013181	putative active site [active]
696747013182	putative metal binding residues [ion binding]; other site
696747013183	signature motif; other site
696747013184	putative dimer interface [polypeptide binding]; other site
696747013185	putative phosphate binding site [ion binding]; other site
696747013186	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
696747013187	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
696747013188	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
696747013189	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
696747013190	putative substrate binding site [chemical binding]; other site
696747013191	putative ATP binding site [chemical binding]; other site
696747013192	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
696747013193	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696747013194	DNA binding residues [nucleotide binding]
696747013195	dimerization interface [polypeptide binding]; other site
696747013196	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
696747013197	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
696747013198	dimer interface [polypeptide binding]; other site
696747013199	motif 1; other site
696747013200	active site
696747013201	motif 2; other site
696747013202	motif 3; other site
696747013203	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
696747013204	anticodon binding site; other site
696747013205	Repair protein; Region: Repair_PSII; pfam04536
696747013206	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747013207	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747013208	binding surface
696747013209	TPR motif; other site
696747013210	Protein of unknown function, DUF258; Region: DUF258; pfam03193
696747013211	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747013212	WD domain, G-beta repeat; Region: WD40; pfam00400
696747013213	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747013214	structural tetrad; other site
696747013215	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747013216	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747013217	structural tetrad; other site
696747013218	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
696747013219	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
696747013220	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
696747013221	cell division protein FtsZ; Region: ftsZ; TIGR00065
696747013222	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
696747013223	nucleotide binding site [chemical binding]; other site
696747013224	SulA interaction site; other site
696747013225	Caspase domain; Region: Peptidase_C14; pfam00656
696747013226	AAA ATPase domain; Region: AAA_16; pfam13191
696747013227	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747013228	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013229	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013230	Peptidase S8 family domain, uncharacterized subfamily 10; Region: Peptidases_S8_10; cd07494
696747013231	active site
696747013232	catalytic triad [active]
696747013233	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
696747013234	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747013235	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747013236	dimer interface [polypeptide binding]; other site
696747013237	phosphorylation site [posttranslational modification]
696747013238	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747013239	ATP binding site [chemical binding]; other site
696747013240	Mg2+ binding site [ion binding]; other site
696747013241	G-X-G motif; other site
696747013242	Response regulator receiver domain; Region: Response_reg; pfam00072
696747013243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747013244	active site
696747013245	phosphorylation site [posttranslational modification]
696747013246	intermolecular recognition site; other site
696747013247	dimerization interface [polypeptide binding]; other site
696747013248	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747013249	Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534
696747013250	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747013251	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747013252	active site
696747013253	ATP binding site [chemical binding]; other site
696747013254	substrate binding site [chemical binding]; other site
696747013255	activation loop (A-loop); other site
696747013256	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747013257	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013258	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013259	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013260	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
696747013261	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
696747013262	putative tRNA-binding site [nucleotide binding]; other site
696747013263	B3/4 domain; Region: B3_4; pfam03483
696747013264	tRNA synthetase B5 domain; Region: B5; smart00874
696747013265	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
696747013266	dimer interface [polypeptide binding]; other site
696747013267	motif 1; other site
696747013268	motif 3; other site
696747013269	motif 2; other site
696747013270	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
696747013271	YciI-like protein; Reviewed; Region: PRK12864
696747013272	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
696747013273	Sterol carrier protein domain; Region: SCP2_2; pfam13530
696747013274	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
696747013275	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
696747013276	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
696747013277	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
696747013278	Probable transposase; Region: OrfB_IS605; pfam01385
696747013279	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747013280	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747013281	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013282	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013283	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747013284	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013285	putative NTP binding site [chemical binding]; other site
696747013286	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013287	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747013288	putative active site [active]
696747013289	putative nucleic acid binding site [nucleotide binding]; other site
696747013290	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747013291	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747013292	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747013293	active site
696747013294	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013295	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013296	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013297	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013298	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013299	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013300	putative NTP binding site [chemical binding]; other site
696747013301	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013302	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747013303	putative active site [active]
696747013304	putative nucleic acid binding site [nucleotide binding]; other site
696747013305	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747013306	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747013307	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747013308	active site
696747013309	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013310	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747013311	putative active site [active]
696747013312	putative nucleic acid binding site [nucleotide binding]; other site
696747013313	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747013314	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747013315	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747013316	active site
696747013317	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
696747013318	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
696747013319	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
696747013320	dimer interface [polypeptide binding]; other site
696747013321	motif 1; other site
696747013322	active site
696747013323	motif 2; other site
696747013324	motif 3; other site
696747013325	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
696747013326	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
696747013327	RRXRR protein; Region: RRXRR; pfam14239
696747013328	putative phosphate acyltransferase; Provisional; Region: PRK05331
696747013329	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
696747013330	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
696747013331	dimer interface [polypeptide binding]; other site
696747013332	active site
696747013333	CoA binding pocket [chemical binding]; other site
696747013334	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
696747013335	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
696747013336	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
696747013337	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747013338	GAF domain; Region: GAF; pfam01590
696747013339	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747013340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747013341	dimer interface [polypeptide binding]; other site
696747013342	phosphorylation site [posttranslational modification]
696747013343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747013344	ATP binding site [chemical binding]; other site
696747013345	Mg2+ binding site [ion binding]; other site
696747013346	G-X-G motif; other site
696747013347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
696747013348	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
696747013349	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013350	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013351	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747013352	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013353	putative nucleic acid binding site [nucleotide binding]; other site
696747013354	Methyltransferase domain; Region: Methyltransf_24; pfam13578
696747013355	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013356	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747013357	putative active site [active]
696747013358	putative nucleic acid binding site [nucleotide binding]; other site
696747013359	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747013360	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747013361	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747013362	active site
696747013363	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747013364	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013365	putative NTP binding site [chemical binding]; other site
696747013366	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013367	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013368	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
696747013369	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013370	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013371	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747013372	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747013373	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747013374	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747013375	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747013376	PAS fold; Region: PAS; pfam00989
696747013377	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747013378	putative active site [active]
696747013379	heme pocket [chemical binding]; other site
696747013380	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747013381	cyclase homology domain; Region: CHD; cd07302
696747013382	nucleotidyl binding site; other site
696747013383	metal binding site [ion binding]; metal-binding site
696747013384	dimer interface [polypeptide binding]; other site
696747013385	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696747013386	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747013387	ligand binding site [chemical binding]; other site
696747013388	flexible hinge region; other site
696747013389	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
696747013390	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
696747013391	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
696747013392	protein binding site [polypeptide binding]; other site
696747013393	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
696747013394	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747013395	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747013396	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747013397	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747013398	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747013399	active site
696747013400	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747013401	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013402	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
696747013403	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
696747013404	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
696747013405	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747013406	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747013407	active site
696747013408	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013409	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747013410	putative active site [active]
696747013411	putative nucleic acid binding site [nucleotide binding]; other site
696747013412	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013413	putative NTP binding site [chemical binding]; other site
696747013414	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013415	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013416	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
696747013417	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
696747013418	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
696747013419	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
696747013420	active site
696747013421	dimer interface [polypeptide binding]; other site
696747013422	motif 1; other site
696747013423	motif 2; other site
696747013424	motif 3; other site
696747013425	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
696747013426	anticodon binding site; other site
696747013427	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013428	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013429	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747013430	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013431	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013432	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747013433	putative active site [active]
696747013434	putative nucleic acid binding site [nucleotide binding]; other site
696747013435	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747013436	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747013437	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747013438	active site
696747013439	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
696747013440	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
696747013441	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
696747013442	Transposase; Region: DEDD_Tnp_IS110; pfam01548
696747013443	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
696747013444	MarR family; Region: MarR_2; cl17246
696747013445	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
696747013446	active site
696747013447	catalytic residues [active]
696747013448	DNA binding site [nucleotide binding]
696747013449	Int/Topo IB signature motif; other site
696747013450	Class I aldolases; Region: Aldolase_Class_I; cl17187
696747013451	HEAT repeats; Region: HEAT_2; pfam13646
696747013452	HEAT repeats; Region: HEAT_2; pfam13646
696747013453	HEAT repeats; Region: HEAT_2; pfam13646
696747013454	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
696747013455	HEAT repeats; Region: HEAT_2; pfam13646
696747013456	HEAT repeats; Region: HEAT_2; pfam13646
696747013457	HEAT repeats; Region: HEAT_2; pfam13646
696747013458	HEAT repeats; Region: HEAT_2; pfam13646
696747013459	HEAT repeats; Region: HEAT_2; pfam13646
696747013460	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747013461	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747013462	Probable transposase; Region: OrfB_IS605; pfam01385
696747013463	Probable transposase; Region: OrfB_IS605; pfam01385
696747013464	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747013465	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747013466	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
696747013467	PemK-like protein; Region: PemK; pfam02452
696747013468	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
696747013469	putative active site [active]
696747013470	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
696747013471	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
696747013472	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013473	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013474	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747013475	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013476	putative active site [active]
696747013477	putative NTP binding site [chemical binding]; other site
696747013478	putative nucleic acid binding site [nucleotide binding]; other site
696747013479	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747013480	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747013481	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747013482	active site
696747013483	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747013484	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747013485	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
696747013486	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
696747013487	Walker A/P-loop; other site
696747013488	ATP binding site [chemical binding]; other site
696747013489	Q-loop/lid; other site
696747013490	ABC transporter signature motif; other site
696747013491	Walker B; other site
696747013492	D-loop; other site
696747013493	H-loop/switch region; other site
696747013494	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
696747013495	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
696747013496	Walker A/P-loop; other site
696747013497	ATP binding site [chemical binding]; other site
696747013498	Q-loop/lid; other site
696747013499	ABC transporter signature motif; other site
696747013500	Walker B; other site
696747013501	D-loop; other site
696747013502	H-loop/switch region; other site
696747013503	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
696747013504	NMT1-like family; Region: NMT1_2; pfam13379
696747013505	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
696747013506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747013507	dimer interface [polypeptide binding]; other site
696747013508	conserved gate region; other site
696747013509	putative PBP binding loops; other site
696747013510	ABC-ATPase subunit interface; other site
696747013511	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747013512	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
696747013513	NMT1-like family; Region: NMT1_2; pfam13379
696747013514	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747013515	NACHT domain; Region: NACHT; pfam05729
696747013516	Walker A motif; other site
696747013517	ATP binding site [chemical binding]; other site
696747013518	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
696747013519	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747013520	NACHT domain; Region: NACHT; pfam05729
696747013521	Walker A motif; other site
696747013522	ATP binding site [chemical binding]; other site
696747013523	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
696747013524	putative FMN binding site [chemical binding]; other site
696747013525	NADPH bind site [chemical binding]; other site
696747013526	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
696747013527	putative active site [active]
696747013528	putative catalytic triad [active]
696747013529	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
696747013530	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747013531	putative active site [active]
696747013532	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747013533	Probable transposase; Region: OrfB_IS605; pfam01385
696747013534	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747013535	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747013536	putative active site [active]
696747013537	Transposase IS200 like; Region: Y1_Tnp; pfam01797
696747013538	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
696747013539	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
696747013540	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
696747013541	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
696747013542	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
696747013543	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
696747013544	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
696747013545	YcaO-like family; Region: YcaO; pfam02624
696747013546	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
696747013547	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
696747013548	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
696747013549	cyanobactin biosynthesis protein, PatB/AcyB/McaB family; Region: patB_acyB_mcaB; TIGR04220
696747013550	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
696747013551	putative active site [active]
696747013552	putative catalytic triad [active]
696747013553	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
696747013554	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
696747013555	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747013556	putative active site [active]
696747013557	AAA ATPase domain; Region: AAA_16; pfam13191
696747013558	AAA domain; Region: AAA_22; pfam13401
696747013559	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
696747013560	ATP-grasp domain; Region: ATP-grasp_4; cl17255
696747013561	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747013562	putative active site [active]
696747013563	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
696747013564	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
696747013565	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
696747013566	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
696747013567	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
696747013568	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
696747013569	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
696747013570	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
696747013571	SnoaL-like domain; Region: SnoaL_2; pfam12680
696747013572	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
696747013573	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
696747013574	active site
696747013575	homodimer interface [polypeptide binding]; other site
696747013576	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747013577	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013578	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013579	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747013580	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013581	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747013582	binding surface
696747013583	TPR repeat; Region: TPR_11; pfam13414
696747013584	TPR motif; other site
696747013585	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
696747013586	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747013587	binding surface
696747013588	TPR motif; other site
696747013589	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747013590	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747013591	active site
696747013592	ATP binding site [chemical binding]; other site
696747013593	substrate binding site [chemical binding]; other site
696747013594	activation loop (A-loop); other site
696747013595	TPR repeat; Region: TPR_11; pfam13414
696747013596	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747013597	binding surface
696747013598	TPR motif; other site
696747013599	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747013600	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747013601	binding surface
696747013602	TPR motif; other site
696747013603	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747013604	binding surface
696747013605	TPR motif; other site
696747013606	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747013607	binding surface
696747013608	TPR motif; other site
696747013609	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747013610	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
696747013611	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
696747013612	putative active site [active]
696747013613	oxyanion strand; other site
696747013614	catalytic triad [active]
696747013615	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
696747013616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747013617	S-adenosylmethionine binding site [chemical binding]; other site
696747013618	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
696747013619	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
696747013620	homodimer interface [polypeptide binding]; other site
696747013621	metal binding site [ion binding]; metal-binding site
696747013622	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
696747013623	homodimer interface [polypeptide binding]; other site
696747013624	active site
696747013625	putative chemical substrate binding site [chemical binding]; other site
696747013626	metal binding site [ion binding]; metal-binding site
696747013627	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
696747013628	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
696747013629	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
696747013630	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
696747013631	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696747013632	motif II; other site
696747013633	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747013634	Uncharacterized conserved protein [Function unknown]; Region: COG0398
696747013635	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
696747013636	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
696747013637	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747013638	FeS/SAM binding site; other site
696747013639	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
696747013640	Ion transport protein; Region: Ion_trans; pfam00520
696747013641	Ion channel; Region: Ion_trans_2; pfam07885
696747013642	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
696747013643	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
696747013644	ligand binding site [chemical binding]; other site
696747013645	flexible hinge region; other site
696747013646	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
696747013647	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
696747013648	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
696747013649	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696747013650	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
696747013651	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
696747013652	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696747013653	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
696747013654	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
696747013655	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
696747013656	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
696747013657	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
696747013658	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
696747013659	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
696747013660	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696747013661	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
696747013662	NAD binding site [chemical binding]; other site
696747013663	putative substrate binding site 2 [chemical binding]; other site
696747013664	putative substrate binding site 1 [chemical binding]; other site
696747013665	active site
696747013666	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747013667	putative active site [active]
696747013668	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747013669	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013670	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747013671	Late competence development protein ComFB; Region: ComFB; pfam10719
696747013672	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
696747013673	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
696747013674	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
696747013675	arginine-tRNA ligase; Region: PLN02286
696747013676	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
696747013677	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
696747013678	active site
696747013679	HIGH motif; other site
696747013680	KMSK motif region; other site
696747013681	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
696747013682	tRNA binding surface [nucleotide binding]; other site
696747013683	anticodon binding site; other site
696747013684	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
696747013685	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747013686	dimerization interface [polypeptide binding]; other site
696747013687	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747013688	dimer interface [polypeptide binding]; other site
696747013689	phosphorylation site [posttranslational modification]
696747013690	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747013691	ATP binding site [chemical binding]; other site
696747013692	Mg2+ binding site [ion binding]; other site
696747013693	G-X-G motif; other site
696747013694	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747013695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747013696	active site
696747013697	phosphorylation site [posttranslational modification]
696747013698	intermolecular recognition site; other site
696747013699	dimerization interface [polypeptide binding]; other site
696747013700	Response regulator receiver domain; Region: Response_reg; pfam00072
696747013701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747013702	active site
696747013703	phosphorylation site [posttranslational modification]
696747013704	intermolecular recognition site; other site
696747013705	dimerization interface [polypeptide binding]; other site
696747013706	Flagellar FliJ protein; Region: FliJ; pfam02050
696747013707	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747013708	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747013709	metal binding site [ion binding]; metal-binding site
696747013710	active site
696747013711	I-site; other site
696747013712	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747013713	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
696747013714	putative active site [active]
696747013715	dimerization interface [polypeptide binding]; other site
696747013716	putative tRNAtyr binding site [nucleotide binding]; other site
696747013717	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
696747013718	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
696747013719	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
696747013720	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461
696747013721	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
696747013722	active site
696747013723	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
696747013724	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
696747013725	TPP-binding site [chemical binding]; other site
696747013726	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
696747013727	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
696747013728	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
696747013729	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
696747013730	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
696747013731	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
696747013732	putative active site [active]
696747013733	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
696747013734	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747013735	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
696747013736	sucrose synthase; Region: sucr_synth; TIGR02470
696747013737	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
696747013738	putative ADP-binding pocket [chemical binding]; other site
696747013739	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
696747013740	active site
696747013741	catalytic triad [active]
696747013742	oxyanion hole [active]
696747013743	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
696747013744	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
696747013745	dimer interface [polypeptide binding]; other site
696747013746	putative anticodon binding site; other site
696747013747	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
696747013748	motif 1; other site
696747013749	active site
696747013750	motif 2; other site
696747013751	motif 3; other site
696747013752	Transposase; Region: HTH_Tnp_IS630; pfam01710
696747013753	Homeodomain-like domain; Region: HTH_23; cl17451
696747013754	Winged helix-turn helix; Region: HTH_33; pfam13592
696747013755	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747013756	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747013757	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
696747013758	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747013759	Transcriptional regulator [Transcription]; Region: LysR; COG0583
696747013760	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
696747013761	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
696747013762	dimerization interface [polypeptide binding]; other site
696747013763	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747013764	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747013765	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
696747013766	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
696747013767	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
696747013768	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
696747013769	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747013770	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747013771	Winged helix-turn helix; Region: HTH_29; pfam13551
696747013772	Homeodomain-like domain; Region: HTH_23; cl17451
696747013773	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013774	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747013775	putative active site [active]
696747013776	putative nucleic acid binding site [nucleotide binding]; other site
696747013777	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747013778	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747013779	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747013780	active site
696747013781	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013782	putative NTP binding site [chemical binding]; other site
696747013783	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013784	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
696747013785	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
696747013786	putative active site [active]
696747013787	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
696747013788	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
696747013789	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
696747013790	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
696747013791	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747013792	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
696747013793	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
696747013794	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747013795	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747013796	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
696747013797	Helix-turn-helix domain; Region: HTH_28; pfam13518
696747013798	UreD urease accessory protein; Region: UreD; pfam01774
696747013799	UreD urease accessory protein; Region: UreD; cl00530
696747013800	SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755
696747013801	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
696747013802	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747013803	cofactor binding site; other site
696747013804	DNA binding site [nucleotide binding]
696747013805	substrate interaction site [chemical binding]; other site
696747013806	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747013807	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747013808	ABC transporter signature motif; other site
696747013809	Walker B; other site
696747013810	D-loop; other site
696747013811	H-loop/switch region; other site
696747013812	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747013813	Walker A/P-loop; other site
696747013814	ATP binding site [chemical binding]; other site
696747013815	Q-loop/lid; other site
696747013816	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747013817	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747013818	active site
696747013819	ATP binding site [chemical binding]; other site
696747013820	substrate binding site [chemical binding]; other site
696747013821	activation loop (A-loop); other site
696747013822	Circadian oscillating protein COP23; Region: COP23; pfam14218
696747013823	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747013824	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747013825	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747013826	structural tetrad; other site
696747013827	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747013828	putative active site [active]
696747013829	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747013830	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747013831	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
696747013832	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
696747013833	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
696747013834	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
696747013835	AAA ATPase domain; Region: AAA_16; pfam13191
696747013836	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747013837	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747013838	structural tetrad; other site
696747013839	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747013840	structural tetrad; other site
696747013841	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747013842	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
696747013843	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
696747013844	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
696747013845	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747013846	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
696747013847	Walker A motif; other site
696747013848	ATP binding site [chemical binding]; other site
696747013849	Walker B motif; other site
696747013850	arginine finger; other site
696747013851	stage V sporulation protein K; Region: spore_V_K; TIGR02881
696747013852	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747013853	Walker A motif; other site
696747013854	ATP binding site [chemical binding]; other site
696747013855	Walker B motif; other site
696747013856	arginine finger; other site
696747013857	GUN4-like; Region: GUN4; pfam05419
696747013858	GUN4-like; Region: GUN4; pfam05419
696747013859	GUN4-like; Region: GUN4; pfam05419
696747013860	GUN4-like; Region: GUN4; pfam05419
696747013861	GUN4-like; Region: GUN4; pfam05419
696747013862	GUN4-like; Region: GUN4; pfam05419
696747013863	XisH protein; Region: XisH; pfam08814
696747013864	XisI protein; Region: XisI; pfam08869
696747013865	XisI protein; Region: XisI; pfam08869
696747013866	XisH protein; Region: XisH; pfam08814
696747013867	GUN4-like; Region: GUN4; pfam05419
696747013868	GUN4-like; Region: GUN4; pfam05419
696747013869	Transposase IS200 like; Region: Y1_Tnp; pfam01797
696747013870	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
696747013871	nucleotide binding site [chemical binding]; other site
696747013872	putative NEF/HSP70 interaction site [polypeptide binding]; other site
696747013873	SBD interface [polypeptide binding]; other site
696747013874	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747013875	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747013876	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747013877	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
696747013878	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
696747013879	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
696747013880	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
696747013881	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
696747013882	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
696747013883	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
696747013884	Subunit I/III interface [polypeptide binding]; other site
696747013885	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
696747013886	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
696747013887	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
696747013888	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
696747013889	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
696747013890	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
696747013891	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
696747013892	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
696747013893	UbiA prenyltransferase family; Region: UbiA; pfam01040
696747013894	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747013895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747013896	active site
696747013897	Response regulator receiver domain; Region: Response_reg; pfam00072
696747013898	phosphorylation site [posttranslational modification]
696747013899	intermolecular recognition site; other site
696747013900	dimerization interface [polypeptide binding]; other site
696747013901	PAS fold; Region: PAS_4; pfam08448
696747013902	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747013903	putative active site [active]
696747013904	heme pocket [chemical binding]; other site
696747013905	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747013906	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747013907	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747013908	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747013909	metal binding site [ion binding]; metal-binding site
696747013910	active site
696747013911	I-site; other site
696747013912	Response regulator receiver domain; Region: Response_reg; pfam00072
696747013913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747013914	active site
696747013915	phosphorylation site [posttranslational modification]
696747013916	intermolecular recognition site; other site
696747013917	dimerization interface [polypeptide binding]; other site
696747013918	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747013919	dimer interface [polypeptide binding]; other site
696747013920	phosphorylation site [posttranslational modification]
696747013921	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747013922	ATP binding site [chemical binding]; other site
696747013923	Mg2+ binding site [ion binding]; other site
696747013924	G-X-G motif; other site
696747013925	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747013926	PAS fold; Region: PAS_3; pfam08447
696747013927	putative active site [active]
696747013928	heme pocket [chemical binding]; other site
696747013929	PAS domain S-box; Region: sensory_box; TIGR00229
696747013930	PAS domain; Region: PAS; smart00091
696747013931	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747013932	PAS fold; Region: PAS_3; pfam08447
696747013933	putative active site [active]
696747013934	heme pocket [chemical binding]; other site
696747013935	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747013936	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747013937	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747013938	GAF domain; Region: GAF; pfam01590
696747013939	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747013940	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747013941	dimer interface [polypeptide binding]; other site
696747013942	phosphorylation site [posttranslational modification]
696747013943	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747013944	ATP binding site [chemical binding]; other site
696747013945	Mg2+ binding site [ion binding]; other site
696747013946	G-X-G motif; other site
696747013947	Response regulator receiver domain; Region: Response_reg; pfam00072
696747013948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747013949	active site
696747013950	phosphorylation site [posttranslational modification]
696747013951	intermolecular recognition site; other site
696747013952	dimerization interface [polypeptide binding]; other site
696747013953	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
696747013954	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747013955	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747013956	metal binding site [ion binding]; metal-binding site
696747013957	active site
696747013958	I-site; other site
696747013959	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747013960	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747013961	structural tetrad; other site
696747013962	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747013963	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747013964	structural tetrad; other site
696747013965	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
696747013966	S-layer homology domain; Region: SLH; pfam00395
696747013967	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
696747013968	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
696747013969	HAS barrel domain; Region: HAS-barrel; pfam09378
696747013970	Uncharacterized conserved protein [Function unknown]; Region: COG2968
696747013971	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
696747013972	Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596
696747013973	YGGT family; Region: YGGT; pfam02325
696747013974	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
696747013975	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
696747013976	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
696747013977	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
696747013978	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013979	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747013980	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013981	putative NTP binding site [chemical binding]; other site
696747013982	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747013983	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747013984	putative active site [active]
696747013985	putative nucleic acid binding site [nucleotide binding]; other site
696747013986	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747013987	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747013988	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747013989	active site
696747013990	Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
696747013991	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
696747013992	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
696747013993	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747013994	dimer interface [polypeptide binding]; other site
696747013995	conserved gate region; other site
696747013996	putative PBP binding loops; other site
696747013997	ABC-ATPase subunit interface; other site
696747013998	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
696747013999	KWG Leptospira; Region: KWG; pfam07656
696747014000	S-layer homology domain; Region: SLH; pfam00395
696747014001	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
696747014002	metal binding site [ion binding]; metal-binding site
696747014003	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747014004	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747014005	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747014006	Probable transposase; Region: OrfB_IS605; pfam01385
696747014007	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747014008	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747014009	putative active site [active]
696747014010	putative nucleic acid binding site [nucleotide binding]; other site
696747014011	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747014012	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747014013	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747014014	active site
696747014015	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747014016	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747014017	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747014018	Winged helix-turn helix; Region: HTH_29; pfam13551
696747014019	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747014020	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
696747014021	Helix-turn-helix domain; Region: HTH_28; pfam13518
696747014022	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
696747014023	dimer interface [polypeptide binding]; other site
696747014024	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
696747014025	Histidine kinase; Region: HisKA_3; pfam07730
696747014026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747014027	ATP binding site [chemical binding]; other site
696747014028	Mg2+ binding site [ion binding]; other site
696747014029	G-X-G motif; other site
696747014030	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
696747014031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747014032	active site
696747014033	phosphorylation site [posttranslational modification]
696747014034	intermolecular recognition site; other site
696747014035	dimerization interface [polypeptide binding]; other site
696747014036	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
696747014037	DNA binding residues [nucleotide binding]
696747014038	dimerization interface [polypeptide binding]; other site
696747014039	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
696747014040	linker region; other site
696747014041	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
696747014042	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
696747014043	AAA domain; Region: AAA_11; pfam13086
696747014044	Part of AAA domain; Region: AAA_19; pfam13245
696747014045	AAA domain; Region: AAA_12; pfam13087
696747014046	PLD-like domain; Region: PLDc_2; pfam13091
696747014047	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
696747014048	putative active site [active]
696747014049	catalytic site [active]
696747014050	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
696747014051	putative active site [active]
696747014052	catalytic site [active]
696747014053	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
696747014054	Part of AAA domain; Region: AAA_19; pfam13245
696747014055	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
696747014056	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
696747014057	Family description; Region: UvrD_C_2; pfam13538
696747014058	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
696747014059	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
696747014060	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747014061	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747014062	active site
696747014063	ATP binding site [chemical binding]; other site
696747014064	substrate binding site [chemical binding]; other site
696747014065	activation loop (A-loop); other site
696747014066	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
696747014067	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
696747014068	substrate binding site [chemical binding]; other site
696747014069	dimer interface [polypeptide binding]; other site
696747014070	ATP binding site [chemical binding]; other site
696747014071	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
696747014072	EVE domain; Region: EVE; cl00728
696747014073	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
696747014074	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
696747014075	Soluble P-type ATPase [General function prediction only]; Region: COG4087
696747014076	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
696747014077	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
696747014078	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
696747014079	catalytic site [active]
696747014080	subunit interface [polypeptide binding]; other site
696747014081	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
696747014082	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
696747014083	anti sigma factor interaction site; other site
696747014084	regulatory phosphorylation site [posttranslational modification]; other site
696747014085	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
696747014086	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
696747014087	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
696747014088	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
696747014089	CHASE2 domain; Region: CHASE2; pfam05226
696747014090	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
696747014091	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
696747014092	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747014093	metal binding site [ion binding]; metal-binding site
696747014094	active site
696747014095	I-site; other site
696747014096	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747014097	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747014098	putative active site [active]
696747014099	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
696747014100	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747014101	binding surface
696747014102	TPR motif; other site
696747014103	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747014104	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747014105	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747014106	binding surface
696747014107	TPR motif; other site
696747014108	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747014109	binding surface
696747014110	TPR motif; other site
696747014111	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747014112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
696747014113	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747014114	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747014115	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747014116	putative active site [active]
696747014117	putative NTP binding site [chemical binding]; other site
696747014118	putative nucleic acid binding site [nucleotide binding]; other site
696747014119	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747014120	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747014121	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747014122	active site
696747014123	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
696747014124	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747014125	cofactor binding site; other site
696747014126	DNA binding site [nucleotide binding]
696747014127	substrate interaction site [chemical binding]; other site
696747014128	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
696747014129	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
696747014130	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
696747014131	putative active site [active]
696747014132	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
696747014133	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
696747014134	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
696747014135	dihydropteroate synthase; Region: DHPS; TIGR01496
696747014136	substrate binding pocket [chemical binding]; other site
696747014137	dimer interface [polypeptide binding]; other site
696747014138	inhibitor binding site; inhibition site
696747014139	triosephosphate isomerase; Provisional; Region: PRK14565
696747014140	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
696747014141	substrate binding site [chemical binding]; other site
696747014142	dimer interface [polypeptide binding]; other site
696747014143	catalytic triad [active]
696747014144	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
696747014145	hydrolase, alpha/beta fold family protein; Region: PLN02824
696747014146	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
696747014147	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
696747014148	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
696747014149	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
696747014150	Sporulation related domain; Region: SPOR; cl10051
696747014151	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
696747014152	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
696747014153	thiamine phosphate binding site [chemical binding]; other site
696747014154	active site
696747014155	pyrophosphate binding site [ion binding]; other site
696747014156	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696747014157	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
696747014158	putative NAD(P) binding site [chemical binding]; other site
696747014159	active site
696747014160	putative substrate binding site [chemical binding]; other site
696747014161	Uncharacterized conserved protein [Function unknown]; Region: COG3339
696747014162	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
696747014163	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
696747014164	Cytochrome c; Region: Cytochrom_C; cl11414
696747014165	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
696747014166	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
696747014167	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
696747014168	NAD binding site [chemical binding]; other site
696747014169	substrate binding site [chemical binding]; other site
696747014170	homodimer interface [polypeptide binding]; other site
696747014171	active site
696747014172	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
696747014173	TPR motif; other site
696747014174	binding surface
696747014175	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747014176	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747014177	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747014178	binding surface
696747014179	TPR motif; other site
696747014180	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747014181	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
696747014182	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
696747014183	putative active site [active]
696747014184	putative metal binding site [ion binding]; other site
696747014185	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
696747014186	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696747014187	motif II; other site
696747014188	CHASE3 domain; Region: CHASE3; pfam05227
696747014189	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
696747014190	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
696747014191	dimer interface [polypeptide binding]; other site
696747014192	putative CheW interface [polypeptide binding]; other site
696747014193	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
696747014194	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
696747014195	substrate binding pocket [chemical binding]; other site
696747014196	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
696747014197	membrane-bound complex binding site; other site
696747014198	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
696747014199	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
696747014200	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
696747014201	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
696747014202	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
696747014203	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
696747014204	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
696747014205	Walker A/P-loop; other site
696747014206	ATP binding site [chemical binding]; other site
696747014207	Q-loop/lid; other site
696747014208	ABC transporter signature motif; other site
696747014209	Walker B; other site
696747014210	D-loop; other site
696747014211	H-loop/switch region; other site
696747014212	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
696747014213	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
696747014214	Walker A/P-loop; other site
696747014215	ATP binding site [chemical binding]; other site
696747014216	Q-loop/lid; other site
696747014217	ABC transporter signature motif; other site
696747014218	Walker B; other site
696747014219	D-loop; other site
696747014220	H-loop/switch region; other site
696747014221	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
696747014222	elongation factor P; Validated; Region: PRK00529
696747014223	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
696747014224	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
696747014225	RNA binding site [nucleotide binding]; other site
696747014226	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
696747014227	RNA binding site [nucleotide binding]; other site
696747014228	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
696747014229	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
696747014230	carboxyltransferase (CT) interaction site; other site
696747014231	biotinylation site [posttranslational modification]; other site
696747014232	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
696747014233	Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909
696747014234	active site
696747014235	Zn binding site [ion binding]; other site
696747014236	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
696747014237	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
696747014238	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747014239	dimer interface [polypeptide binding]; other site
696747014240	phosphorylation site [posttranslational modification]
696747014241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747014242	ATP binding site [chemical binding]; other site
696747014243	Mg2+ binding site [ion binding]; other site
696747014244	G-X-G motif; other site
696747014245	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
696747014246	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
696747014247	active site
696747014248	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
696747014249	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
696747014250	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696747014251	catalytic loop [active]
696747014252	iron binding site [ion binding]; other site
696747014253	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747014254	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747014255	Probable transposase; Region: OrfB_IS605; pfam01385
696747014256	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747014257	Transposase IS200 like; Region: Y1_Tnp; pfam01797
696747014258	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
696747014259	active site
696747014260	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
696747014261	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747014262	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747014263	phosphopeptide binding site; other site
696747014264	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747014265	phosphopeptide binding site; other site
696747014266	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747014267	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747014268	phosphopeptide binding site; other site
696747014269	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747014270	structural tetrad; other site
696747014271	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747014272	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
696747014273	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
696747014274	AAA domain; Region: AAA_13; pfam13166
696747014275	DNA polymerase III subunit delta'; Validated; Region: PRK07399
696747014276	DNA polymerase III subunit delta'; Validated; Region: PRK08485
696747014277	thymidylate kinase; Validated; Region: tmk; PRK00698
696747014278	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
696747014279	TMP-binding site; other site
696747014280	ATP-binding site [chemical binding]; other site
696747014281	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
696747014282	pheophytin binding site; other site
696747014283	chlorophyll binding site; other site
696747014284	quinone binding site; other site
696747014285	Fe binding site [ion binding]; other site
696747014286	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
696747014287	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
696747014288	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
696747014289	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
696747014290	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
696747014291	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
696747014292	substrate binding pocket [chemical binding]; other site
696747014293	membrane-bound complex binding site; other site
696747014294	hinge residues; other site
696747014295	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747014296	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747014297	binding surface
696747014298	TPR motif; other site
696747014299	TPR repeat; Region: TPR_11; pfam13414
696747014300	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
696747014301	23S rRNA binding site [nucleotide binding]; other site
696747014302	L21 binding site [polypeptide binding]; other site
696747014303	L13 binding site [polypeptide binding]; other site
696747014304	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
696747014305	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
696747014306	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
696747014307	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747014308	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747014309	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747014310	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747014311	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747014312	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
696747014313	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
696747014314	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
696747014315	active site
696747014316	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
696747014317	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
696747014318	HEAT repeats; Region: HEAT_2; pfam13646
696747014319	protein binding surface [polypeptide binding]; other site
696747014320	HEAT repeats; Region: HEAT_2; pfam13646
696747014321	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
696747014322	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747014323	TPR motif; other site
696747014324	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747014325	binding surface
696747014326	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
696747014327	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
696747014328	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
696747014329	Walker A/P-loop; other site
696747014330	ATP binding site [chemical binding]; other site
696747014331	Q-loop/lid; other site
696747014332	ABC transporter signature motif; other site
696747014333	Walker B; other site
696747014334	D-loop; other site
696747014335	H-loop/switch region; other site
696747014336	DevC protein; Region: devC; TIGR01185
696747014337	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
696747014338	FtsX-like permease family; Region: FtsX; pfam02687
696747014339	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
696747014340	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
696747014341	HlyD family secretion protein; Region: HlyD_3; pfam13437
696747014342	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
696747014343	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
696747014344	GTPase Era; Reviewed; Region: era; PRK00089
696747014345	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
696747014346	G1 box; other site
696747014347	GTP/Mg2+ binding site [chemical binding]; other site
696747014348	Switch I region; other site
696747014349	G2 box; other site
696747014350	Switch II region; other site
696747014351	G3 box; other site
696747014352	G4 box; other site
696747014353	G5 box; other site
696747014354	KH domain; Region: KH_2; pfam07650
696747014355	G-X-X-G motif; other site
696747014356	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
696747014357	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
696747014358	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
696747014359	HlyD family secretion protein; Region: HlyD_3; pfam13437
696747014360	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
696747014361	FtsX-like permease family; Region: FtsX; pfam02687
696747014362	Stage II sporulation protein; Region: SpoIID; pfam08486
696747014363	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
696747014364	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
696747014365	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
696747014366	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
696747014367	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
696747014368	RNA binding site [nucleotide binding]; other site
696747014369	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
696747014370	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
696747014371	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
696747014372	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
696747014373	catalytic site [active]
696747014374	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
696747014375	PhoD-like phosphatase; Region: PhoD; pfam09423
696747014376	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
696747014377	putative active site [active]
696747014378	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
696747014379	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747014380	S-adenosylmethionine binding site [chemical binding]; other site
696747014381	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
696747014382	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
696747014383	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
696747014384	active site
696747014385	HIGH motif; other site
696747014386	KMSKS motif; other site
696747014387	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
696747014388	anticodon binding site; other site
696747014389	tRNA binding surface [nucleotide binding]; other site
696747014390	Uncharacterized conserved protein [Function unknown]; Region: COG1432
696747014391	LabA_like proteins; Region: LabA; cd10911
696747014392	putative metal binding site [ion binding]; other site
696747014393	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
696747014394	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
696747014395	phosphoribulokinase; Provisional; Region: PRK07429
696747014396	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
696747014397	active site
696747014398	Protein kinase domain; Region: Pkinase; pfam00069
696747014399	FOG: WD40-like repeat [Function unknown]; Region: COG1520
696747014400	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
696747014401	active site
696747014402	Trp docking motif [polypeptide binding]; other site
696747014403	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
696747014404	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
696747014405	Trp docking motif [polypeptide binding]; other site
696747014406	active site
696747014407	PQQ-like domain; Region: PQQ_2; pfam13360
696747014408	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
696747014409	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747014410	FeS/SAM binding site; other site
696747014411	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
696747014412	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
696747014413	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
696747014414	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
696747014415	RNA binding surface [nucleotide binding]; other site
696747014416	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
696747014417	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
696747014418	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
696747014419	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
696747014420	substrate binding site; other site
696747014421	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696747014422	extended (e) SDRs; Region: SDR_e; cd08946
696747014423	NAD(P) binding site [chemical binding]; other site
696747014424	active site
696747014425	substrate binding site [chemical binding]; other site
696747014426	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
696747014427	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747014428	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747014429	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
696747014430	Methyltransferase domain; Region: Methyltransf_23; pfam13489
696747014431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
696747014432	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
696747014433	Ycf39; Provisional; Region: ycf39; CHL00194
696747014434	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
696747014435	NAD(P) binding site [chemical binding]; other site
696747014436	putative active site [active]
696747014437	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
696747014438	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
696747014439	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696747014440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747014441	active site
696747014442	phosphorylation site [posttranslational modification]
696747014443	intermolecular recognition site; other site
696747014444	dimerization interface [polypeptide binding]; other site
696747014445	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747014446	DNA binding site [nucleotide binding]
696747014447	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
696747014448	Uncharacterized conserved protein [Function unknown]; Region: COG2006
696747014449	Domain of unknown function (DUF362); Region: DUF362; pfam04015
696747014450	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
696747014451	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
696747014452	generic binding surface II; other site
696747014453	ssDNA binding site; other site
696747014454	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747014455	ATP binding site [chemical binding]; other site
696747014456	putative Mg++ binding site [ion binding]; other site
696747014457	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747014458	nucleotide binding region [chemical binding]; other site
696747014459	ATP-binding site [chemical binding]; other site
696747014460	TPR repeat; Region: TPR_11; pfam13414
696747014461	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747014462	binding surface
696747014463	TPR motif; other site
696747014464	TPR repeat; Region: TPR_11; pfam13414
696747014465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747014466	binding surface
696747014467	TPR motif; other site
696747014468	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747014469	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
696747014470	elongation factor Ts; Reviewed; Region: tsf; PRK12332
696747014471	UBA/TS-N domain; Region: UBA; pfam00627
696747014472	Elongation factor TS; Region: EF_TS; pfam00889
696747014473	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
696747014474	rRNA interaction site [nucleotide binding]; other site
696747014475	S8 interaction site; other site
696747014476	putative laminin-1 binding site; other site
696747014477	PsaX family; Region: PsaX; pfam08078
696747014478	TIGR02646 family protein; Region: TIGR02646
696747014479	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
696747014480	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
696747014481	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
696747014482	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
696747014483	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747014484	Switch II region; other site
696747014485	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747014486	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
696747014487	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
696747014488	XisH protein; Region: XisH; pfam08814
696747014489	XisI protein; Region: XisI; pfam08869
696747014490	Fic family protein [Function unknown]; Region: COG3177
696747014491	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747014492	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747014493	putative active site [active]
696747014494	putative nucleic acid binding site [nucleotide binding]; other site
696747014495	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747014496	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747014497	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747014498	active site
696747014499	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747014500	putative NTP binding site [chemical binding]; other site
696747014501	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747014502	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747014503	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
696747014504	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747014505	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747014506	putative active site [active]
696747014507	putative nucleic acid binding site [nucleotide binding]; other site
696747014508	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747014509	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747014510	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747014511	active site
696747014512	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747014513	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747014514	putative NTP binding site [chemical binding]; other site
696747014515	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747014516	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747014517	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747014518	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747014519	putative active site [active]
696747014520	putative nucleic acid binding site [nucleotide binding]; other site
696747014521	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747014522	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747014523	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747014524	active site
696747014525	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747014526	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747014527	putative NTP binding site [chemical binding]; other site
696747014528	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747014529	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
696747014530	Fic/DOC family; Region: Fic; pfam02661
696747014531	2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275
696747014532	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747014533	AAA domain; Region: AAA_21; pfam13304
696747014534	Walker A/P-loop; other site
696747014535	ATP binding site [chemical binding]; other site
696747014536	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
696747014537	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747014538	putative active site [active]
696747014539	Pseudomurein-binding repeat; Region: PMBR; pfam09373
696747014540	DEAD-like helicases superfamily; Region: DEXDc; smart00487
696747014541	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
696747014542	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
696747014543	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
696747014544	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716
696747014545	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
696747014546	feedback inhibition sensing region; other site
696747014547	homohexameric interface [polypeptide binding]; other site
696747014548	nucleotide binding site [chemical binding]; other site
696747014549	N-acetyl-L-glutamate binding site [chemical binding]; other site
696747014550	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
696747014551	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
696747014552	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747014553	catalytic residue [active]
696747014554	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
696747014555	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
696747014556	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
696747014557	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
696747014558	catalytic site [active]
696747014559	putative active site [active]
696747014560	putative substrate binding site [chemical binding]; other site
696747014561	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
696747014562	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
696747014563	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
696747014564	active site
696747014565	intersubunit interface [polypeptide binding]; other site
696747014566	Zn2+ binding site [ion binding]; other site
696747014567	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
696747014568	homotrimer interaction site [polypeptide binding]; other site
696747014569	putative active site [active]
696747014570	Peptidase S8 family domain, uncharacterized subfamily 6; Region: Peptidases_S8_6; cd07490
696747014571	active site
696747014572	catalytic triad [active]
696747014573	Cache domain; Region: Cache_1; pfam02743
696747014574	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
696747014575	dimerization interface [polypeptide binding]; other site
696747014576	Heme NO binding associated; Region: HNOBA; pfam07701
696747014577	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
696747014578	cyclase homology domain; Region: CHD; cd07302
696747014579	nucleotidyl binding site; other site
696747014580	metal binding site [ion binding]; metal-binding site
696747014581	dimer interface [polypeptide binding]; other site
696747014582	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
696747014583	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
696747014584	Protein of unknown function (DUF721); Region: DUF721; cl02324
696747014585	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
696747014586	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
696747014587	substrate binding site [chemical binding]; other site
696747014588	oxyanion hole (OAH) forming residues; other site
696747014589	trimer interface [polypeptide binding]; other site
696747014590	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
696747014591	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
696747014592	dimerization interface [polypeptide binding]; other site
696747014593	putative ATP binding site [chemical binding]; other site
696747014594	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
696747014595	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
696747014596	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
696747014597	Pantoate-beta-alanine ligase; Region: PanC; cd00560
696747014598	active site
696747014599	ATP-binding site [chemical binding]; other site
696747014600	pantoate-binding site; other site
696747014601	HXXH motif; other site
696747014602	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
696747014603	CMP-binding site; other site
696747014604	The sites determining sugar specificity; other site
696747014605	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
696747014606	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
696747014607	NodB motif; other site
696747014608	active site
696747014609	catalytic site [active]
696747014610	metal binding site [ion binding]; metal-binding site
696747014611	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
696747014612	MoaE homodimer interface [polypeptide binding]; other site
696747014613	MoaD interaction [polypeptide binding]; other site
696747014614	active site residues [active]
696747014615	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
696747014616	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
696747014617	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
696747014618	DNA binding residues [nucleotide binding]
696747014619	Putative zinc-finger; Region: zf-HC2; pfam13490
696747014620	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
696747014621	putative active site pocket [active]
696747014622	dimerization interface [polypeptide binding]; other site
696747014623	putative catalytic residue [active]
696747014624	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
696747014625	active site
696747014626	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
696747014627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747014628	S-adenosylmethionine binding site [chemical binding]; other site
696747014629	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
696747014630	PspC domain; Region: PspC; pfam04024
696747014631	flavoprotein, HI0933 family; Region: TIGR00275
696747014632	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
696747014633	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
696747014634	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
696747014635	NodB motif; other site
696747014636	active site
696747014637	catalytic site [active]
696747014638	metal binding site [ion binding]; metal-binding site
696747014639	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747014640	FG-GAP repeat; Region: FG-GAP_2; pfam14312
696747014641	FG-GAP repeat; Region: FG-GAP_2; pfam14312
696747014642	FG-GAP repeat; Region: FG-GAP_2; pfam14312
696747014643	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
696747014644	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
696747014645	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
696747014646	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
696747014647	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
696747014648	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
696747014649	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747014650	putative active site [active]
696747014651	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747014652	putative active site [active]
696747014653	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747014654	putative active site [active]
696747014655	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747014656	putative active site [active]
696747014657	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747014658	putative active site [active]
696747014659	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747014660	putative active site [active]
696747014661	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747014662	putative active site [active]
696747014663	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
696747014664	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
696747014665	RuvA N terminal domain; Region: RuvA_N; pfam01330
696747014666	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
696747014667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
696747014668	Major Facilitator Superfamily; Region: MFS_1; pfam07690
696747014669	putative substrate translocation pore; other site
696747014670	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
696747014671	MPN+ (JAMM) motif; other site
696747014672	Zinc-binding site [ion binding]; other site
696747014673	Bacterial Ig-like domain; Region: Big_5; pfam13205
696747014674	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
696747014675	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
696747014676	putative active site [active]
696747014677	putative metal binding site [ion binding]; other site
696747014678	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
696747014679	FAD binding domain; Region: FAD_binding_4; pfam01565
696747014680	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
696747014681	DNA protecting protein DprA; Region: dprA; TIGR00732
696747014682	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
696747014683	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
696747014684	substrate binding site; other site
696747014685	dimer interface; other site
696747014686	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
696747014687	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
696747014688	putative active site [active]
696747014689	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
696747014690	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
696747014691	Protein of unknown function (DUF512); Region: DUF512; pfam04459
696747014692	Bacitracin resistance protein BacA; Region: BacA; pfam02673
696747014693	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
696747014694	AMIN domain; Region: AMIN; pfam11741
696747014695	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
696747014696	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
696747014697	active site
696747014698	metal binding site [ion binding]; metal-binding site
696747014699	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
696747014700	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
696747014701	catalytic triad [active]
696747014702	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
696747014703	nudix motif; other site
696747014704	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
696747014705	Serine hydrolase; Region: Ser_hydrolase; cl17834
696747014706	pantothenate kinase; Reviewed; Region: PRK13331
696747014707	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747014708	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747014709	active site
696747014710	ATP binding site [chemical binding]; other site
696747014711	substrate binding site [chemical binding]; other site
696747014712	activation loop (A-loop); other site
696747014713	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747014714	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747014715	structural tetrad; other site
696747014716	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
696747014717	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
696747014718	peptide binding site [polypeptide binding]; other site
696747014719	dimer interface [polypeptide binding]; other site
696747014720	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
696747014721	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
696747014722	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
696747014723	Ligand Binding Site [chemical binding]; other site
696747014724	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
696747014725	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747014726	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747014727	active site
696747014728	ATP binding site [chemical binding]; other site
696747014729	substrate binding site [chemical binding]; other site
696747014730	activation loop (A-loop); other site
696747014731	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747014732	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747014733	structural tetrad; other site
696747014734	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
696747014735	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
696747014736	[2Fe-2S] cluster binding site [ion binding]; other site
696747014737	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
696747014738	Transcriptional regulator [Transcription]; Region: LytR; COG1316
696747014739	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
696747014740	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
696747014741	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
696747014742	substrate binding site [chemical binding]; other site
696747014743	hexamer interface [polypeptide binding]; other site
696747014744	metal binding site [ion binding]; metal-binding site
696747014745	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
696747014746	CHASE2 domain; Region: CHASE2; pfam05226
696747014747	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747014748	cyclase homology domain; Region: CHD; cd07302
696747014749	nucleotidyl binding site; other site
696747014750	metal binding site [ion binding]; metal-binding site
696747014751	dimer interface [polypeptide binding]; other site
696747014752	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
696747014753	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
696747014754	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
696747014755	Mg++ binding site [ion binding]; other site
696747014756	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
696747014757	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
696747014758	dimer interface [polypeptide binding]; other site
696747014759	conserved gate region; other site
696747014760	putative PBP binding loops; other site
696747014761	ABC-ATPase subunit interface; other site
696747014762	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
696747014763	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
696747014764	active site
696747014765	Zn binding site [ion binding]; other site
696747014766	DEAD-like helicases superfamily; Region: DEXDc; smart00487
696747014767	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747014768	ATP binding site [chemical binding]; other site
696747014769	putative Mg++ binding site [ion binding]; other site
696747014770	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747014771	nucleotide binding region [chemical binding]; other site
696747014772	ATP-binding site [chemical binding]; other site
696747014773	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
696747014774	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
696747014775	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
696747014776	trmE is a tRNA modification GTPase; Region: trmE; cd04164
696747014777	G1 box; other site
696747014778	GTP/Mg2+ binding site [chemical binding]; other site
696747014779	Switch I region; other site
696747014780	G2 box; other site
696747014781	Switch II region; other site
696747014782	G3 box; other site
696747014783	G4 box; other site
696747014784	G5 box; other site
696747014785	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
696747014786	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
696747014787	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
696747014788	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
696747014789	MraW methylase family; Region: Methyltransf_5; pfam01795
696747014790	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
696747014791	Response regulator receiver domain; Region: Response_reg; pfam00072
696747014792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747014793	active site
696747014794	phosphorylation site [posttranslational modification]
696747014795	intermolecular recognition site; other site
696747014796	dimerization interface [polypeptide binding]; other site
696747014797	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747014798	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747014799	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
696747014800	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
696747014801	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
696747014802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
696747014803	ATP binding site [chemical binding]; other site
696747014804	Mg2+ binding site [ion binding]; other site
696747014805	G-X-G motif; other site
696747014806	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
696747014807	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
696747014808	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747014809	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747014810	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
696747014811	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
696747014812	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
696747014813	Ligand Binding Site [chemical binding]; other site
696747014814	K+-transporting ATPase, c chain; Region: KdpC; cl00944
696747014815	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747014816	Switch II region; other site
696747014817	FHA domain; Region: FHA; pfam00498
696747014818	phosphopeptide binding site; other site
696747014819	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747014820	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747014821	phosphopeptide binding site; other site
696747014822	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
696747014823	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747014824	active site
696747014825	ATP binding site [chemical binding]; other site
696747014826	substrate binding site [chemical binding]; other site
696747014827	activation loop (A-loop); other site
696747014828	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
696747014829	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
696747014830	GUN4-like; Region: GUN4; pfam05419
696747014831	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
696747014832	ParB-like nuclease domain; Region: ParB; smart00470
696747014833	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
696747014834	metal ion-dependent adhesion site (MIDAS); other site
696747014835	Protein phosphatase 2C; Region: PP2C_2; pfam13672
696747014836	active site
696747014837	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747014838	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
696747014839	active site
696747014840	ATP binding site [chemical binding]; other site
696747014841	substrate binding site [chemical binding]; other site
696747014842	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
696747014843	substrate binding site [chemical binding]; other site
696747014844	activation loop (A-loop); other site
696747014845	activation loop (A-loop); other site
696747014846	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747014847	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747014848	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747014849	putative active site [active]
696747014850	putative NTP binding site [chemical binding]; other site
696747014851	putative nucleic acid binding site [nucleotide binding]; other site
696747014852	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747014853	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747014854	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747014855	active site
696747014856	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
696747014857	metal ion-dependent adhesion site (MIDAS); other site
696747014858	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
696747014859	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
696747014860	pyruvate kinase; Provisional; Region: PRK06354
696747014861	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
696747014862	domain interfaces; other site
696747014863	active site
696747014864	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
696747014865	Helix-turn-helix domain; Region: HTH_28; pfam13518
696747014866	Winged helix-turn helix; Region: HTH_29; pfam13551
696747014867	Homeodomain-like domain; Region: HTH_32; pfam13565
696747014868	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747014869	DDE superfamily endonuclease; Region: DDE_3; pfam13358
696747014870	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
696747014871	active site
696747014872	catalytic triad [active]
696747014873	oxyanion hole [active]
696747014874	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
696747014875	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
696747014876	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914
696747014877	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
696747014878	cell division protein; Validated; Region: ftsH; CHL00176
696747014879	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747014880	Walker A motif; other site
696747014881	ATP binding site [chemical binding]; other site
696747014882	Walker B motif; other site
696747014883	arginine finger; other site
696747014884	Peptidase family M41; Region: Peptidase_M41; pfam01434
696747014885	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
696747014886	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
696747014887	active site
696747014888	Na/Ca binding site [ion binding]; other site
696747014889	catalytic site [active]
696747014890	hypothetical protein; Provisional; Region: PRK11281
696747014891	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
696747014892	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
696747014893	DctM-like transporters; Region: DctM; pfam06808
696747014894	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
696747014895	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
696747014896	putative ligand binding site [chemical binding]; other site
696747014897	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
696747014898	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
696747014899	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
696747014900	TM-ABC transporter signature motif; other site
696747014901	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
696747014902	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
696747014903	TM-ABC transporter signature motif; other site
696747014904	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
696747014905	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
696747014906	Walker A/P-loop; other site
696747014907	ATP binding site [chemical binding]; other site
696747014908	Q-loop/lid; other site
696747014909	ABC transporter signature motif; other site
696747014910	Walker B; other site
696747014911	D-loop; other site
696747014912	H-loop/switch region; other site
696747014913	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
696747014914	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
696747014915	Walker A/P-loop; other site
696747014916	ATP binding site [chemical binding]; other site
696747014917	Q-loop/lid; other site
696747014918	ABC transporter signature motif; other site
696747014919	Walker B; other site
696747014920	D-loop; other site
696747014921	H-loop/switch region; other site
696747014922	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
696747014923	hydroxyglutarate oxidase; Provisional; Region: PRK11728
696747014924	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
696747014925	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
696747014926	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747014927	NAD(P) binding site [chemical binding]; other site
696747014928	active site
696747014929	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
696747014930	FIST N domain; Region: FIST; pfam08495
696747014931	FIST C domain; Region: FIST_C; pfam10442
696747014932	CP12 domain; Region: CP12; pfam02672
696747014933	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
696747014934	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
696747014935	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747014936	Probable transposase; Region: OrfB_IS605; pfam01385
696747014937	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747014938	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747014939	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
696747014940	non-specific DNA binding site [nucleotide binding]; other site
696747014941	salt bridge; other site
696747014942	sequence-specific DNA binding site [nucleotide binding]; other site
696747014943	Domain of unknown function (DUF955); Region: DUF955; pfam06114
696747014944	MAPEG family; Region: MAPEG; pfam01124
696747014945	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747014946	metal binding site [ion binding]; metal-binding site
696747014947	active site
696747014948	I-site; other site
696747014949	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
696747014950	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
696747014951	DNA-binding site [nucleotide binding]; DNA binding site
696747014952	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
696747014953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747014954	homodimer interface [polypeptide binding]; other site
696747014955	catalytic residue [active]
696747014956	5-oxoprolinase; Region: PLN02666
696747014957	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
696747014958	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
696747014959	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
696747014960	homoserine kinase; Provisional; Region: PRK01212
696747014961	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
696747014962	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
696747014963	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
696747014964	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
696747014965	putative catalytic residue [active]
696747014966	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
696747014967	metal ion-dependent adhesion site (MIDAS); other site
696747014968	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
696747014969	Double zinc ribbon; Region: DZR; pfam12773
696747014970	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747014971	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747014972	active site
696747014973	ATP binding site [chemical binding]; other site
696747014974	substrate binding site [chemical binding]; other site
696747014975	activation loop (A-loop); other site
696747014976	FOG: WD40 repeat [General function prediction only]; Region: COG2319
696747014977	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
696747014978	structural tetrad; other site
696747014979	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747014980	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747014981	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747014982	putative active site [active]
696747014983	putative NTP binding site [chemical binding]; other site
696747014984	putative nucleic acid binding site [nucleotide binding]; other site
696747014985	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747014986	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747014987	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747014988	active site
696747014989	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
696747014990	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
696747014991	active site
696747014992	dimer interface [polypeptide binding]; other site
696747014993	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
696747014994	dimer interface [polypeptide binding]; other site
696747014995	active site
696747014996	phosphate acetyltransferase; Reviewed; Region: PRK05632
696747014997	DRTGG domain; Region: DRTGG; pfam07085
696747014998	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
696747014999	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747015000	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747015001	metal binding site [ion binding]; metal-binding site
696747015002	active site
696747015003	I-site; other site
696747015004	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747015005	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747015006	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
696747015007	Predicted transcriptional regulators [Transcription]; Region: COG1733
696747015008	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
696747015009	phosphoenolpyruvate synthase; Validated; Region: PRK06464
696747015010	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
696747015011	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
696747015012	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
696747015013	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
696747015014	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
696747015015	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
696747015016	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
696747015017	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696747015018	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
696747015019	catalytic loop [active]
696747015020	iron binding site [ion binding]; other site
696747015021	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
696747015022	CAAX protease self-immunity; Region: Abi; pfam02517
696747015023	Predicted transcriptional regulator [Transcription]; Region: COG2345
696747015024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015025	PAS domain; Region: PAS_9; pfam13426
696747015026	putative active site [active]
696747015027	heme pocket [chemical binding]; other site
696747015028	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747015029	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747015030	dimer interface [polypeptide binding]; other site
696747015031	phosphorylation site [posttranslational modification]
696747015032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747015033	ATP binding site [chemical binding]; other site
696747015034	Mg2+ binding site [ion binding]; other site
696747015035	G-X-G motif; other site
696747015036	short chain dehydrogenase; Validated; Region: PRK07069
696747015037	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747015038	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747015039	NAD(P) binding site [chemical binding]; other site
696747015040	active site
696747015041	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
696747015042	DNA binding residues [nucleotide binding]
696747015043	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747015044	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747015045	putative active site [active]
696747015046	putative nucleic acid binding site [nucleotide binding]; other site
696747015047	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747015048	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747015049	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747015050	active site
696747015051	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747015052	putative NTP binding site [chemical binding]; other site
696747015053	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747015054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747015055	Probable transposase; Region: OrfB_IS605; pfam01385
696747015056	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
696747015057	Protein of unknown function DUF45; Region: DUF45; cl00636
696747015058	Protein of unknown function DUF45; Region: DUF45; cl00636
696747015059	Protein of unknown function DUF45; Region: DUF45; cl00636
696747015060	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
696747015061	haemagglutination activity domain; Region: Haemagg_act; pfam05860
696747015062	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
696747015063	dephospho-CoA kinase; Region: TIGR00152
696747015064	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
696747015065	CoA-binding site [chemical binding]; other site
696747015066	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
696747015067	heme binding pocket [chemical binding]; other site
696747015068	heme ligand [chemical binding]; other site
696747015069	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
696747015070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
696747015071	active site
696747015072	phosphorylation site [posttranslational modification]
696747015073	intermolecular recognition site; other site
696747015074	PAS fold; Region: PAS_4; pfam08448
696747015075	PAS domain S-box; Region: sensory_box; TIGR00229
696747015076	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015077	putative active site [active]
696747015078	heme pocket [chemical binding]; other site
696747015079	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
696747015080	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015081	putative active site [active]
696747015082	heme pocket [chemical binding]; other site
696747015083	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015084	putative active site [active]
696747015085	heme pocket [chemical binding]; other site
696747015086	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747015087	dimer interface [polypeptide binding]; other site
696747015088	phosphorylation site [posttranslational modification]
696747015089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747015090	ATP binding site [chemical binding]; other site
696747015091	Mg2+ binding site [ion binding]; other site
696747015092	G-X-G motif; other site
696747015093	Protein of unknown function (DUF2459); Region: DUF2459; pfam09601
696747015094	recombination protein F; Reviewed; Region: recF; PRK00064
696747015095	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
696747015096	Walker A/P-loop; other site
696747015097	ATP binding site [chemical binding]; other site
696747015098	Q-loop/lid; other site
696747015099	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747015100	ABC transporter signature motif; other site
696747015101	Walker B; other site
696747015102	D-loop; other site
696747015103	H-loop/switch region; other site
696747015104	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
696747015105	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
696747015106	phosphopeptide binding site; other site
696747015107	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747015108	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747015109	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
696747015110	cyclase homology domain; Region: CHD; cd07302
696747015111	nucleotidyl binding site; other site
696747015112	metal binding site [ion binding]; metal-binding site
696747015113	dimer interface [polypeptide binding]; other site
696747015114	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747015115	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747015116	Probable transposase; Region: OrfB_IS605; pfam01385
696747015117	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
696747015118	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
696747015119	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
696747015120	alpha subunit interface [polypeptide binding]; other site
696747015121	TPP binding site [chemical binding]; other site
696747015122	heterodimer interface [polypeptide binding]; other site
696747015123	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
696747015124	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
696747015125	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
696747015126	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
696747015127	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
696747015128	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
696747015129	Protein export membrane protein; Region: SecD_SecF; pfam02355
696747015130	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
696747015131	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
696747015132	substrate binding pocket [chemical binding]; other site
696747015133	membrane-bound complex binding site; other site
696747015134	hinge residues; other site
696747015135	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
696747015136	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
696747015137	Protein of unknown function (DUF420); Region: DUF420; cl00989
696747015138	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
696747015139	dimerization interface [polypeptide binding]; other site
696747015140	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
696747015141	ATP binding site [chemical binding]; other site
696747015142	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
696747015143	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
696747015144	RNase_H superfamily; Region: RNase_H_2; pfam13482
696747015145	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
696747015146	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
696747015147	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
696747015148	catalytic residue [active]
696747015149	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
696747015150	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747015151	DNA methylase; Region: N6_N4_Mtase; pfam01555
696747015152	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
696747015153	active site
696747015154	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
696747015155	Fe-S cluster binding site [ion binding]; other site
696747015156	active site
696747015157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
696747015158	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
696747015159	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
696747015160	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
696747015161	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
696747015162	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
696747015163	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
696747015164	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
696747015165	shikimate binding site; other site
696747015166	NAD(P) binding site [chemical binding]; other site
696747015167	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
696747015168	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
696747015169	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
696747015170	HSP70 interaction site [polypeptide binding]; other site
696747015171	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
696747015172	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
696747015173	Coenzyme A binding pocket [chemical binding]; other site
696747015174	HEAT repeats; Region: HEAT_2; pfam13646
696747015175	HEAT repeats; Region: HEAT_2; pfam13646
696747015176	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
696747015177	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
696747015178	GTP binding site; other site
696747015179	Methyltransferase domain; Region: Methyltransf_31; pfam13847
696747015180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747015181	S-adenosylmethionine binding site [chemical binding]; other site
696747015182	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
696747015183	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
696747015184	nucleotide binding site [chemical binding]; other site
696747015185	putative NEF/HSP70 interaction site [polypeptide binding]; other site
696747015186	SBD interface [polypeptide binding]; other site
696747015187	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
696747015188	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747015189	binding surface
696747015190	TPR repeat; Region: TPR_11; pfam13414
696747015191	TPR motif; other site
696747015192	DnaJ domain; Region: DnaJ; pfam00226
696747015193	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
696747015194	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
696747015195	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
696747015196	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
696747015197	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
696747015198	DEAD-like helicases superfamily; Region: DEXDc; smart00487
696747015199	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
696747015200	ATP binding site [chemical binding]; other site
696747015201	putative Mg++ binding site [ion binding]; other site
696747015202	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
696747015203	nucleotide binding region [chemical binding]; other site
696747015204	ATP-binding site [chemical binding]; other site
696747015205	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
696747015206	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
696747015207	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
696747015208	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
696747015209	active site
696747015210	catalytic site [active]
696747015211	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
696747015212	oligomeric interface; other site
696747015213	putative active site [active]
696747015214	homodimer interface [polypeptide binding]; other site
696747015215	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
696747015216	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
696747015217	Walker A/P-loop; other site
696747015218	ATP binding site [chemical binding]; other site
696747015219	Q-loop/lid; other site
696747015220	ABC transporter signature motif; other site
696747015221	Walker B; other site
696747015222	D-loop; other site
696747015223	H-loop/switch region; other site
696747015224	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
696747015225	HD domain; Region: HD_4; pfam13328
696747015226	Thymidylate synthase complementing protein; Region: Thy1; cl03630
696747015227	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
696747015228	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
696747015229	protein-splicing catalytic site; other site
696747015230	Thymidylate synthase complementing protein; Region: Thy1; cl03630
696747015231	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
696747015232	trimer interface [polypeptide binding]; other site
696747015233	active site
696747015234	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
696747015235	catalytic motif [active]
696747015236	Zn binding site [ion binding]; other site
696747015237	von Willebrand factor; Region: vWF_A; pfam12450
696747015238	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
696747015239	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
696747015240	metal ion-dependent adhesion site (MIDAS); other site
696747015241	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
696747015242	AAA domain; Region: AAA_23; pfam13476
696747015243	AAA domain; Region: AAA_21; pfam13304
696747015244	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
696747015245	active site
696747015246	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747015247	Q-loop/lid; other site
696747015248	ABC transporter signature motif; other site
696747015249	Walker B; other site
696747015250	D-loop; other site
696747015251	H-loop/switch region; other site
696747015252	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
696747015253	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
696747015254	Na binding site [ion binding]; other site
696747015255	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747015256	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747015257	putative active site [active]
696747015258	putative NTP binding site [chemical binding]; other site
696747015259	putative nucleic acid binding site [nucleotide binding]; other site
696747015260	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747015261	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747015262	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747015263	active site
696747015264	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747015265	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
696747015266	Switch II region; other site
696747015267	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747015268	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
696747015269	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747015270	putative NTP binding site [chemical binding]; other site
696747015271	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747015272	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747015273	putative active site [active]
696747015274	putative nucleic acid binding site [nucleotide binding]; other site
696747015275	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747015276	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747015277	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747015278	active site
696747015279	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
696747015280	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
696747015281	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015282	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747015283	putative active site [active]
696747015284	heme pocket [chemical binding]; other site
696747015285	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747015286	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015287	putative active site [active]
696747015288	heme pocket [chemical binding]; other site
696747015289	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015290	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
696747015291	putative active site [active]
696747015292	heme pocket [chemical binding]; other site
696747015293	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015294	putative active site [active]
696747015295	heme pocket [chemical binding]; other site
696747015296	PAS fold; Region: PAS_3; pfam08447
696747015297	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015298	putative active site [active]
696747015299	heme pocket [chemical binding]; other site
696747015300	PAS fold; Region: PAS_4; pfam08448
696747015301	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015302	putative active site [active]
696747015303	heme pocket [chemical binding]; other site
696747015304	PAS fold; Region: PAS_4; pfam08448
696747015305	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747015306	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747015307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747015308	dimer interface [polypeptide binding]; other site
696747015309	phosphorylation site [posttranslational modification]
696747015310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747015311	ATP binding site [chemical binding]; other site
696747015312	Mg2+ binding site [ion binding]; other site
696747015313	G-X-G motif; other site
696747015314	Protein kinase domain; Region: Pkinase; pfam00069
696747015315	Catalytic domain of Protein Kinases; Region: PKc; cd00180
696747015316	active site
696747015317	ATP binding site [chemical binding]; other site
696747015318	substrate binding site [chemical binding]; other site
696747015319	activation loop (A-loop); other site
696747015320	AAA ATPase domain; Region: AAA_16; pfam13191
696747015321	Predicted ATPase [General function prediction only]; Region: COG3899
696747015322	Walker A motif; other site
696747015323	ATP binding site [chemical binding]; other site
696747015324	Walker B motif; other site
696747015325	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
696747015326	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
696747015327	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747015328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747015329	ATP binding site [chemical binding]; other site
696747015330	Mg2+ binding site [ion binding]; other site
696747015331	G-X-G motif; other site
696747015332	Domain of unknown function (DUF305); Region: DUF305; pfam03713
696747015333	Haemolytic domain; Region: Haemolytic; cl00506
696747015334	Tubulin like; Region: Tubulin_2; pfam13809
696747015335	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
696747015336	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
696747015337	metal ion-dependent adhesion site (MIDAS); other site
696747015338	TPR repeat; Region: TPR_11; pfam13414
696747015339	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
696747015340	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
696747015341	putative ligand binding site [chemical binding]; other site
696747015342	EamA-like transporter family; Region: EamA; cl17759
696747015343	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
696747015344	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
696747015345	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
696747015346	CAAX protease self-immunity; Region: Abi; pfam02517
696747015347	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
696747015348	catalytic loop [active]
696747015349	iron binding site [ion binding]; other site
696747015350	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
696747015351	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015352	PAS domain; Region: PAS_9; pfam13426
696747015353	putative active site [active]
696747015354	heme pocket [chemical binding]; other site
696747015355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747015356	dimer interface [polypeptide binding]; other site
696747015357	phosphorylation site [posttranslational modification]
696747015358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747015359	ATP binding site [chemical binding]; other site
696747015360	Mg2+ binding site [ion binding]; other site
696747015361	G-X-G motif; other site
696747015362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747015363	active site
696747015364	phosphorylation site [posttranslational modification]
696747015365	intermolecular recognition site; other site
696747015366	dimerization interface [polypeptide binding]; other site
696747015367	Response regulator receiver domain; Region: Response_reg; pfam00072
696747015368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747015369	active site
696747015370	phosphorylation site [posttranslational modification]
696747015371	intermolecular recognition site; other site
696747015372	dimerization interface [polypeptide binding]; other site
696747015373	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
696747015374	putative binding surface; other site
696747015375	active site
696747015376	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696747015377	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
696747015378	Cysteine-rich domain; Region: CCG; pfam02754
696747015379	Cysteine-rich domain; Region: CCG; pfam02754
696747015380	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
696747015381	FAD binding domain; Region: FAD_binding_4; pfam01565
696747015382	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
696747015383	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
696747015384	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
696747015385	Family description; Region: VCBS; pfam13517
696747015386	Family description; Region: VCBS; pfam13517
696747015387	Family description; Region: VCBS; pfam13517
696747015388	Family description; Region: VCBS; pfam13517
696747015389	Family description; Region: VCBS; pfam13517
696747015390	Calx-beta domain; Region: Calx-beta; cl02522
696747015391	Calx-beta domain; Region: Calx-beta; cl02522
696747015392	Calx-beta domain; Region: Calx-beta; cl02522
696747015393	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015394	FOG: WD40-like repeat [Function unknown]; Region: COG1520
696747015395	Calx-beta domain; Region: Calx-beta; pfam03160
696747015396	Calx-beta domain; Region: Calx-beta; cl02522
696747015397	Calx-beta domain; Region: Calx-beta; cl02522
696747015398	Calx-beta domain; Region: Calx-beta; cl02522
696747015399	Calx-beta domain; Region: Calx-beta; pfam03160
696747015400	Calx-beta domain; Region: Calx-beta; pfam03160
696747015401	Calx-beta domain; Region: Calx-beta; pfam03160
696747015402	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015403	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015404	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015405	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015406	FOG: WD40-like repeat [Function unknown]; Region: COG1520
696747015407	Calx-beta domain; Region: Calx-beta; pfam03160
696747015408	Calx-beta domain; Region: Calx-beta; pfam03160
696747015409	Calx-beta domain; Region: Calx-beta; pfam03160
696747015410	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015411	FOG: WD40-like repeat [Function unknown]; Region: COG1520
696747015412	Calx-beta domain; Region: Calx-beta; pfam03160
696747015413	Calx-beta domain; Region: Calx-beta; pfam03160
696747015414	Calx-beta domain; Region: Calx-beta; pfam03160
696747015415	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015416	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015417	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015418	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015419	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015420	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015421	Calx-beta domain; Region: Calx-beta; pfam03160
696747015422	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015423	Calx-beta domain; Region: Calx-beta; pfam03160
696747015424	Calx-beta domain; Region: Calx-beta; pfam03160
696747015425	Calx-beta domain; Region: Calx-beta; cl02522
696747015426	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015427	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015428	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015429	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015430	Integrin, beta chain; Region: Integrin_beta; cl17693
696747015431	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015432	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015433	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015434	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015435	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015436	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
696747015437	PAS fold; Region: PAS_3; pfam08447
696747015438	PAS domain S-box; Region: sensory_box; TIGR00229
696747015439	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015440	putative active site [active]
696747015441	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015442	PAS domain; Region: PAS_9; pfam13426
696747015443	putative active site [active]
696747015444	heme pocket [chemical binding]; other site
696747015445	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
696747015446	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
696747015447	metal binding site [ion binding]; metal-binding site
696747015448	active site
696747015449	I-site; other site
696747015450	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
696747015451	Predicted transcriptional regulator [Transcription]; Region: COG2944
696747015452	Protein of unknown function (DUF433); Region: DUF433; cl01030
696747015453	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
696747015454	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
696747015455	glutaminase active site [active]
696747015456	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
696747015457	dimer interface [polypeptide binding]; other site
696747015458	active site
696747015459	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
696747015460	dimer interface [polypeptide binding]; other site
696747015461	active site
696747015462	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
696747015463	photosystem I subunit VII; Region: psaC; CHL00065
696747015464	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
696747015465	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
696747015466	Cysteine-rich domain; Region: CCG; pfam02754
696747015467	Cysteine-rich domain; Region: CCG; pfam02754
696747015468	acyl carrier protein; Provisional; Region: acpP; PRK00982
696747015469	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
696747015470	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
696747015471	dimer interface [polypeptide binding]; other site
696747015472	active site
696747015473	glutamate racemase; Provisional; Region: PRK00865
696747015474	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
696747015475	ATP cone domain; Region: ATP-cone; pfam03477
696747015476	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
696747015477	photosystem II 47 kDa protein; Region: psbB; CHL00062
696747015478	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747015479	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
696747015480	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
696747015481	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
696747015482	Domain of unknown function DUF20; Region: UPF0118; pfam01594
696747015483	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
696747015484	PAS domain S-box; Region: sensory_box; TIGR00229
696747015485	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015486	putative active site [active]
696747015487	heme pocket [chemical binding]; other site
696747015488	PAS fold; Region: PAS_7; pfam12860
696747015489	PAS domain S-box; Region: sensory_box; TIGR00229
696747015490	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
696747015491	putative active site [active]
696747015492	heme pocket [chemical binding]; other site
696747015493	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
696747015494	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
696747015495	dimer interface [polypeptide binding]; other site
696747015496	phosphorylation site [posttranslational modification]
696747015497	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747015498	ATP binding site [chemical binding]; other site
696747015499	Mg2+ binding site [ion binding]; other site
696747015500	G-X-G motif; other site
696747015501	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
696747015502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747015503	active site
696747015504	phosphorylation site [posttranslational modification]
696747015505	intermolecular recognition site; other site
696747015506	dimerization interface [polypeptide binding]; other site
696747015507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747015508	Response regulator receiver domain; Region: Response_reg; pfam00072
696747015509	active site
696747015510	phosphorylation site [posttranslational modification]
696747015511	intermolecular recognition site; other site
696747015512	dimerization interface [polypeptide binding]; other site
696747015513	Heme NO binding associated; Region: HNOBA; pfam07701
696747015514	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
696747015515	cyclase homology domain; Region: CHD; cd07302
696747015516	nucleotidyl binding site; other site
696747015517	metal binding site [ion binding]; metal-binding site
696747015518	dimer interface [polypeptide binding]; other site
696747015519	Protein of function (DUF2518); Region: DUF2518; pfam10726
696747015520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
696747015521	S-adenosylmethionine binding site [chemical binding]; other site
696747015522	Uncharacterized conserved protein [Function unknown]; Region: COG1262
696747015523	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
696747015524	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696747015525	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747015526	NAD(P) binding site [chemical binding]; other site
696747015527	active site
696747015528	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
696747015529	putative active site [active]
696747015530	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
696747015531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
696747015532	NAD(P) binding site [chemical binding]; other site
696747015533	active site
696747015534	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
696747015535	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696747015536	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
696747015537	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
696747015538	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
696747015539	Ligand Binding Site [chemical binding]; other site
696747015540	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
696747015541	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
696747015542	Magnesium ion binding site [ion binding]; other site
696747015543	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
696747015544	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
696747015545	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
696747015546	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
696747015547	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
696747015548	ligand binding site [chemical binding]; other site
696747015549	homodimer interface [polypeptide binding]; other site
696747015550	NAD(P) binding site [chemical binding]; other site
696747015551	trimer interface B [polypeptide binding]; other site
696747015552	trimer interface A [polypeptide binding]; other site
696747015553	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
696747015554	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
696747015555	ribonuclease P; Reviewed; Region: rnpA; PRK03031
696747015556	Bacterial PH domain; Region: DUF304; pfam03703
696747015557	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
696747015558	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
696747015559	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
696747015560	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
696747015561	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
696747015562	G-X-X-G motif; other site
696747015563	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
696747015564	RxxxH motif; other site
696747015565	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
696747015566	Ycf46; Provisional; Region: ycf46; CHL00195
696747015567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747015568	Walker A motif; other site
696747015569	ATP binding site [chemical binding]; other site
696747015570	Walker B motif; other site
696747015571	arginine finger; other site
696747015572	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
696747015573	ADP-glucose phosphorylase; Region: PLN02643
696747015574	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
696747015575	nucleotide binding site/active site [active]
696747015576	HIT family signature motif; other site
696747015577	catalytic residue [active]
696747015578	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
696747015579	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
696747015580	dimer interface [polypeptide binding]; other site
696747015581	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
696747015582	active site
696747015583	Fe binding site [ion binding]; other site
696747015584	LabA_like proteins; Region: LabA_like; cd06167
696747015585	putative metal binding site [ion binding]; other site
696747015586	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
696747015587	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747015588	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747015589	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747015590	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747015591	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747015592	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747015593	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
696747015594	potassium/proton antiporter; Reviewed; Region: PRK05326
696747015595	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
696747015596	Beta-lactamase; Region: Beta-lactamase; pfam00144
696747015597	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
696747015598	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
696747015599	active site
696747015600	catalytic triad [active]
696747015601	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
696747015602	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
696747015603	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
696747015604	Transcriptional regulator [Transcription]; Region: LytR; COG1316
696747015605	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
696747015606	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
696747015607	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
696747015608	Substrate binding site; other site
696747015609	Cupin domain; Region: Cupin_2; cl17218
696747015610	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
696747015611	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
696747015612	active site
696747015613	catalytic tetrad [active]
696747015614	Clostridial hydrophobic W; Region: ChW; pfam07538
696747015615	Clostridial hydrophobic W; Region: ChW; cl02763
696747015616	Clostridial hydrophobic W; Region: ChW; pfam07538
696747015617	cobalamin synthase; Reviewed; Region: cobS; PRK00235
696747015618	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
696747015619	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
696747015620	photosystem II protein K; Region: psbK; CHL00047
696747015621	TPR repeat; Region: TPR_11; pfam13414
696747015622	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747015623	binding surface
696747015624	TPR motif; other site
696747015625	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747015626	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747015627	binding surface
696747015628	TPR repeat; Region: TPR_11; pfam13414
696747015629	TPR motif; other site
696747015630	Tetratricopeptide repeat; Region: TPR_16; pfam13432
696747015631	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
696747015632	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
696747015633	dimer interface [polypeptide binding]; other site
696747015634	pyridoxal 5'-phosphate binding site [chemical binding]; other site
696747015635	catalytic residue [active]
696747015636	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
696747015637	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
696747015638	dimerization interface [polypeptide binding]; other site
696747015639	active site
696747015640	metal binding site [ion binding]; metal-binding site
696747015641	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
696747015642	dsRNA binding site [nucleotide binding]; other site
696747015643	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
696747015644	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
696747015645	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
696747015646	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
696747015647	chlorophyll binding site; other site
696747015648	pheophytin binding site; other site
696747015649	quinone binding site; other site
696747015650	Fe binding site [ion binding]; other site
696747015651	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747015652	putative active site [active]
696747015653	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
696747015654	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
696747015655	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
696747015656	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747015657	FeS/SAM binding site; other site
696747015658	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
696747015659	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747015660	FeS/SAM binding site; other site
696747015661	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
696747015662	AAA ATPase domain; Region: AAA_16; pfam13191
696747015663	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
696747015664	putative active site [active]
696747015665	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
696747015666	protein I interface; other site
696747015667	D2 interface; other site
696747015668	protein T interface; other site
696747015669	chlorophyll binding site; other site
696747015670	beta carotene binding site; other site
696747015671	pheophytin binding site; other site
696747015672	manganese-stabilizing polypeptide interface; other site
696747015673	CP43 interface; other site
696747015674	protein L interface; other site
696747015675	oxygen evolving complex binding site; other site
696747015676	bromide binding site; other site
696747015677	quinone binding site; other site
696747015678	Fe binding site [ion binding]; other site
696747015679	core light harvesting interface; other site
696747015680	cytochrome b559 alpha subunit interface; other site
696747015681	cytochrome c-550 interface; other site
696747015682	protein J interface; other site
696747015683	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
696747015684	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
696747015685	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
696747015686	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
696747015687	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
696747015688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
696747015689	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
696747015690	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
696747015691	GTP-binding protein LepA; Provisional; Region: PRK05433
696747015692	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
696747015693	G1 box; other site
696747015694	putative GEF interaction site [polypeptide binding]; other site
696747015695	GTP/Mg2+ binding site [chemical binding]; other site
696747015696	Switch I region; other site
696747015697	G2 box; other site
696747015698	G3 box; other site
696747015699	Switch II region; other site
696747015700	G4 box; other site
696747015701	G5 box; other site
696747015702	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
696747015703	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
696747015704	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
696747015705	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
696747015706	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
696747015707	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
696747015708	Catalytic site [active]
696747015709	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
696747015710	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
696747015711	putative di-iron ligands [ion binding]; other site
696747015712	Circadian oscillating protein COP23; Region: COP23; pfam14218
696747015713	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
696747015714	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
696747015715	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
696747015716	substrate binding site [chemical binding]; other site
696747015717	ATP binding site [chemical binding]; other site
696747015718	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
696747015719	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
696747015720	5S rRNA interface [nucleotide binding]; other site
696747015721	CTC domain interface [polypeptide binding]; other site
696747015722	L16 interface [polypeptide binding]; other site
696747015723	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
696747015724	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
696747015725	GDP-binding site [chemical binding]; other site
696747015726	ACT binding site; other site
696747015727	IMP binding site; other site
696747015728	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
696747015729	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
696747015730	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
696747015731	active site
696747015732	DNA polymerase I; Provisional; Region: PRK05755
696747015733	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
696747015734	active site
696747015735	metal binding site 1 [ion binding]; metal-binding site
696747015736	putative 5' ssDNA interaction site; other site
696747015737	metal binding site 3; metal-binding site
696747015738	metal binding site 2 [ion binding]; metal-binding site
696747015739	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
696747015740	putative DNA binding site [nucleotide binding]; other site
696747015741	putative metal binding site [ion binding]; other site
696747015742	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
696747015743	active site
696747015744	catalytic site [active]
696747015745	substrate binding site [chemical binding]; other site
696747015746	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
696747015747	active site
696747015748	DNA binding site [nucleotide binding]
696747015749	catalytic site [active]
696747015750	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
696747015751	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
696747015752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
696747015753	ATP binding site [chemical binding]; other site
696747015754	Mg2+ binding site [ion binding]; other site
696747015755	G-X-G motif; other site
696747015756	Response regulator receiver domain; Region: Response_reg; pfam00072
696747015757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747015758	active site
696747015759	phosphorylation site [posttranslational modification]
696747015760	intermolecular recognition site; other site
696747015761	dimerization interface [polypeptide binding]; other site
696747015762	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
696747015763	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
696747015764	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
696747015765	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
696747015766	anti sigma factor interaction site; other site
696747015767	regulatory phosphorylation site [posttranslational modification]; other site
696747015768	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
696747015769	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
696747015770	dimer interface [polypeptide binding]; other site
696747015771	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
696747015772	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
696747015773	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
696747015774	dimerization interface [polypeptide binding]; other site
696747015775	DPS ferroxidase diiron center [ion binding]; other site
696747015776	ion pore; other site
696747015777	30S ribosomal protein S1; Reviewed; Region: PRK07400
696747015778	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
696747015779	RNA binding site [nucleotide binding]; other site
696747015780	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
696747015781	RNA binding site [nucleotide binding]; other site
696747015782	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
696747015783	RNA binding site [nucleotide binding]; other site
696747015784	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
696747015785	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696747015786	motif II; other site
696747015787	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
696747015788	S-adenosylmethionine synthetase; Validated; Region: PRK05250
696747015789	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
696747015790	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
696747015791	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
696747015792	ThiS interaction site; other site
696747015793	putative active site [active]
696747015794	tetramer interface [polypeptide binding]; other site
696747015795	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747015796	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747015797	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747015798	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
696747015799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
696747015800	active site
696747015801	phosphorylation site [posttranslational modification]
696747015802	intermolecular recognition site; other site
696747015803	dimerization interface [polypeptide binding]; other site
696747015804	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
696747015805	DNA binding site [nucleotide binding]
696747015806	protoporphyrinogen oxidase; Region: PLN02576
696747015807	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
696747015808	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
696747015809	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
696747015810	MutS domain III; Region: MutS_III; pfam05192
696747015811	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
696747015812	Walker A/P-loop; other site
696747015813	ATP binding site [chemical binding]; other site
696747015814	Q-loop/lid; other site
696747015815	ABC transporter signature motif; other site
696747015816	Walker B; other site
696747015817	D-loop; other site
696747015818	H-loop/switch region; other site
696747015819	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
696747015820	Smr domain; Region: Smr; pfam01713
696747015821	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
696747015822	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
696747015823	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
696747015824	DALR anticodon binding domain; Region: DALR_1; smart00836
696747015825	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
696747015826	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
696747015827	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
696747015828	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
696747015829	putative acyl-acceptor binding pocket; other site
696747015830	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
696747015831	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
696747015832	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
696747015833	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
696747015834	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
696747015835	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
696747015836	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
696747015837	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
696747015838	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
696747015839	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
696747015840	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
696747015841	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
696747015842	Walker A motif; other site
696747015843	ATP binding site [chemical binding]; other site
696747015844	Walker B motif; other site
696747015845	arginine finger; other site
696747015846	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
696747015847	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
696747015848	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
696747015849	active site
696747015850	ATP binding site [chemical binding]; other site
696747015851	substrate binding site [chemical binding]; other site
696747015852	activation loop (A-loop); other site
696747015853	PBP superfamily domain; Region: PBP_like_2; pfam12849
696747015854	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
696747015855	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949
696747015856	Phage protein D [General function prediction only]; Region: COG3500
696747015857	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
696747015858	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
696747015859	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
696747015860	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
696747015861	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
696747015862	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
696747015863	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
696747015864	trimer interface [polypeptide binding]; other site
696747015865	active site
696747015866	UDP-GlcNAc binding site [chemical binding]; other site
696747015867	lipid binding site [chemical binding]; lipid-binding site
696747015868	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
696747015869	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
696747015870	Radical SAM superfamily; Region: Radical_SAM; pfam04055
696747015871	FeS/SAM binding site; other site
696747015872	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
696747015873	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
696747015874	CpeS-like protein; Region: CpeS; pfam09367
696747015875	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
696747015876	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
696747015877	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
696747015878	P loop; other site
696747015879	Nucleotide binding site [chemical binding]; other site
696747015880	DTAP/Switch II; other site
696747015881	Switch I; other site
696747015882	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
696747015883	putative dimer interface [polypeptide binding]; other site
696747015884	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
696747015885	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
696747015886	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
696747015887	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
696747015888	putative active site [active]
696747015889	putative nucleic acid binding site [nucleotide binding]; other site
696747015890	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
696747015891	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
696747015892	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
696747015893	active site
696747015894	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
696747015895	NTP binding site [chemical binding]; other site
696747015896	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
696747015897	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
696747015898	rod shape-determining protein MreC; Provisional; Region: PRK13922
696747015899	rod shape-determining protein MreC; Region: MreC; pfam04085
696747015900	rod shape-determining protein MreB; Provisional; Region: PRK13927
696747015901	MreB and similar proteins; Region: MreB_like; cd10225
696747015902	nucleotide binding site [chemical binding]; other site
696747015903	Mg binding site [ion binding]; other site
696747015904	putative protofilament interaction site [polypeptide binding]; other site
696747015905	RodZ interaction site [polypeptide binding]; other site
696747015906	glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399
696747015907	Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506
696747015908	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
696747015909	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747015910	binding surface
696747015911	TPR motif; other site
696747015912	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747015913	binding surface
696747015914	TPR motif; other site
696747015915	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747015916	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
696747015917	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747015918	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
696747015919	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747015920	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747015921	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747015922	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747015923	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
696747015924	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
696747015925	Late competence development protein ComFB; Region: ComFB; pfam10719
696747015926	Helix-turn-helix domain; Region: HTH_25; pfam13413
696747015927	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747015928	binding surface
696747015929	TPR motif; other site
696747015930	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747015931	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747015932	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747015933	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747015934	binding surface
696747015935	TPR motif; other site
696747015936	Tetratricopeptide repeat; Region: TPR_12; pfam13424
696747015937	CHAT domain; Region: CHAT; pfam12770
696747015938	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
696747015939	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
696747015940	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
696747015941	Walker A/P-loop; other site
696747015942	ATP binding site [chemical binding]; other site
696747015943	Q-loop/lid; other site
696747015944	ABC transporter signature motif; other site
696747015945	Walker B; other site
696747015946	D-loop; other site
696747015947	H-loop/switch region; other site
696747015948	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
696747015949	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
696747015950	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
696747015951	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
696747015952	catalytic residue [active]
696747015953	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
696747015954	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
696747015955	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
696747015956	active site
696747015957	metal binding site [ion binding]; metal-binding site
696747015958	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
696747015959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
696747015960	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
696747015961	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
696747015962	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
696747015963	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
696747015964	substrate binding site [chemical binding]; other site
696747015965	ligand binding site [chemical binding]; other site
696747015966	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
696747015967	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
696747015968	substrate binding site [chemical binding]; other site
696747015969	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
696747015970	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
696747015971	active site
696747015972	substrate binding site [chemical binding]; other site
696747015973	cosubstrate binding site; other site
696747015974	catalytic site [active]
696747015975	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
696747015976	active site
696747015977	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
696747015978	Ligand Binding Site [chemical binding]; other site
696747015979	Molecular Tunnel; other site
696747015980	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
696747015981	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747015982	Walker A/P-loop; other site
696747015983	ATP binding site [chemical binding]; other site
696747015984	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
696747015985	Q-loop/lid; other site
696747015986	ABC transporter signature motif; other site
696747015987	Walker B; other site
696747015988	D-loop; other site
696747015989	H-loop/switch region; other site
696747015990	hypothetical protein; Provisional; Region: PRK06850
696747015991	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
696747015992	Active Sites [active]
696747015993	DGQHR domain; Region: DGQHR; TIGR03187
696747015994	DNA-sulfur modification-associated; Region: DndB; cl17621
696747015995	DNA-sulfur modification-associated; Region: DndB; pfam14072
696747015996	DGQHR domain; Region: DGQHR; TIGR03187
696747015997	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
696747015998	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
696747015999	motif II; other site
696747016000	Uncharacterized conserved protein [Function unknown]; Region: COG4279
696747016001	Uncharacterized conserved protein [Function unknown]; Region: COG4279
696747016002	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
696747016003	YcfA-like protein; Region: YcfA; pfam07927
696747016004	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
696747016005	TPR repeat; Region: TPR_11; pfam13414
696747016006	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
696747016007	binding surface
696747016008	TPR motif; other site
696747016009	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
696747016010	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
696747016011	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
696747016012	Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493